Exponent values of fractal model for landslide frequency-area distribution collected form the worldwide observations.
\r\n\tThere will be a chapter on secondary causes of sexual dysfunction disorders related to diabetes, cardiovascular disease, and obesity. A chapter on remedial measures to enhance sexual activity and maintain human relationships will be discussed. As there is a growing number of cancer survivors a chapter on cancer-related sexual dysfunction will be welcomed for including it.
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Landslides can mobilize a cascades of loose materials from hillslopes into river channels, affecting the sediment yield of watersheds and its corresponding consequent evolution of river channels, habitats, deltas and coast lines in the downstream. Typically, this geomorphic erosion (i.e., landslides) occurs in mountainous landscapes with strong ground motion from earthquakes [1], snow-melt infiltration [2], and rainfall infiltration [3, 4].
Taiwan is an island of an area of 36,000 km2, and two-thirds of its area are covered by rugged mountains and hills, steep topography, young (3 million years) and weak geological formulations, active earthquakes, and loose soils [5]. Earthquakes and heavy rains play a major role on contributing to the occurrence of landslides. Many landslides have been mainly triggered by typhoons that usually brought heavy rains in Taiwan. In recently decades, the most severe landslides triggered by heavy rains in Taiwan are those by Typhoon Morakot in the period of August 5 to 10, 2009. Typhoon Morakot brought more than 2000 mm rainfall during 6 days, leading to a large number of landslides, especially in southern Taiwan. The understanding of landslide hazards has been still limited until Typhoon Morakot hit in Taiwan that caused a total of 45,125 of landslides and the catastrophic Hsiaolin landslide in the Cishan River watershed (CRW). The Hsiaolin landslide generated a huge debris dam that blocked the Cishan River and its consequent dam break caused more than 400 people dead and missing; also, the village itself no longer exists [44].
After Typhoon Morakot, the natural environmental conditions of watershed systems were significantly changed due to severe landslides and associated damages. For developing cost-effective landslide hazards mitigation strategies and measures, we should have better understanding on the causes and effects of landslides. Basing on the data taken from the study area of CRW, we devote this chapter to: (1) address the causes and effects of landslides in this watershed (i.e., CRW) accompanied with the primary factors of landslide triggering such as the geologic and topographic settings and rainfall characteristics; (2) evaluate the devastation of landslides caused by Typhoon Morakot and its aftermath; (3) assess the present status of landslide hazards mitigation strategies in Taiwan. Results from landslide research in this chapter lays the foundation and establishes the guidelines for developing possible effective landslide hazards mitigation strategies and measures.
The island of Taiwan is located at the obliquely convergent boundary of the Eurasian continent and the Philippine Sea plate and separated from Eurasia continent by the 175 km wide Taiwan Strait. This collision of the Luzon arc results in two-thirds of its area being covered by rugged mountains and hills, steep topography, young (3 million years) and weak geological formulations, active earthquakes, and loose soils [5]. The average elevation is 765 m and about 31% of the total island area has an elevation of exceeding 1000 m. Most mountains are very steep with slope gradients of 25o and local relief of 1000 m or more.
Taiwan is periodically disturbed by typhoons and local storms and experiences a 2500 mm mean annual rainfall depth equivalent to a triple of global mean values. Majority of rainfall occurs between June and October when trade wind and typhoons strongly provide the sources of moisture. During the rainy seasons, the geological and climatic regimes usually combine to generate severe hillslope denudation by soil erosion, landslides, and debris flows.
Dadson et al. [6] indicates that the rivers of Taiwan transfer suspended sediment of 384 Mt/y to the ocean based on the data measured between 1970 and 1999. This represents 1.9% of estimated global river-borne suspended-sediment discharges but is only derived form 0.024% of Earth’s subaerial surface. The Erosion rate were quite high in the eastern Central Range and southwestern region of Taiwan, especially on the Western Foothills with a rate of up to 60 mm/y [6].
Cishan River watershed lies on the Western Foothills of Taiwan and has an area of 842 km2 and a mean gradient of 39.3%. Its maximum elevation of 3950 m is near the Southwestern Foothills of Jade Mountain, gradually decreasing from north to south to 31 m, with mean elevation of 473 m. Obviously, there is a significant difference between the maximum and minimum elevations in this long, narrow watershed (Figure 1). The geologic setting is underlain by sandstone, shale, slate, and phyllite, and drains geological ages between Eocene to Pleistocene distributed from the upper to lower regions. This is clear that the geological formation is young and weak (between 5.3 and 0.01 million years ago), leading to poorly lithologic resistance to erosion. The Cishan River is 118 km in length, flowing through the watershed. The geomorphic characteristics (i.e., elevation and slope) were obtained by digitizing a 5 × 5 m digital elevation model (provided by Water Resources Agency, Taiwan, WRA) using Geographic Information System (GIS).
Locations and topography of Cishan River watershed (CRW).
Figure 2 shows a geological map of CRW (provided by the Geological Survey Center, MOEA, Taiwan). There are nine lithologic complexes and rock units in the Cishan River watershed: (a) Cholan Formation, Pliocene in age, (b) Hsitsun Formation, Eocene to Oligocene, (c) Juifang Group, Middle Miocene, (d) Lushan Formation, Miocene in age, (e) Sanhsia Formation, Late Miocene to Pliocene, (f) Shihpachungchi Formation, Eocene, (g) Tachien Sandstone, Eocene, (h) Colluvium, Pleistocene, and (i) Alluvium, Holocene. Each complex comprises different types of sedimentary rocks varying in strength. Interbedded sandstone, argillite, phyllite and slate dominate the rocks of Lushan Formation. Juifang Group, Cholan and Sanhsia Formations mainly comprise sandstone and shale. Hsitsun Formation includes the rocks of Slate, sandstone and phyllite. Shihpachungchi and Tachien Sandstone comprise sandstone, slate and shale. Alluvium and Colluvium contain weak sand, gravel and clay.
Map of lithologic complexes for the Cishan River watershed.
The CRW drains tropical monsoon climate zones. The mean annual rainfall is about 3267 mm and the mean annual temperature is 25.1°C. The relative atmospheric moisture averages 75.6%. In this region, the majority of rainfall occurs between June and October because periodic typhoons and trade wind can provide abundant moisture sources during wet season. Conversely, the Center Mountain usually blocks moisture brought by northwestern trade wind, leading to less rainfalls in other months during dry season.
Cishan River watershed drains the Western Foothills of Taiwan, which has a decadal erosion rate of ~30 mm/y. The Cishan River is a main tributary of the Kao-Pin River (the largest river of Taiwan for total river basin) that supplied 49 Mt./y during 1990 and 1999 and this value of river-borne suspended-sediment discharge is only smaller than that supplied from the Beinan River (~88 Mt./y) in Taiwan [6]. The Water Resource Agency (WRA) of Taiwan continuously made stream gauging and a fortnight suspended-sediment sampling at the Shanlin Bridge station near the downstream from 1986 to 2005, restarting from 2010 till now. Based on the data recording at this gauging station, the Cishan River has a mean suspended-sediment concentration of about 696 ppm, annual sediment yield of about 1.06 Mt./y.
Hsiaolin village is a village on the foothill of Hsiendu Mountain in the Cishan River watershed. At 6:16 AM (local time) on 9 August in 2009, the catastrophic landslide was triggered on the hillslope of Hsiendu Mountain when rainfall reached 1676.5 mm equal to 72-hour accumulative rainfall obtained from the rainfall record of the Jiashan station, with the peak hourly rainfall intensity of 95 mm/h (Figure 3). This landslide is the largest landslide occurred during Typhoon Morakot, damming the near Cishan River channel and was break at about 7:40 AM on 9 August. This dam-break flood led to abrupt change in the water level of the Cishan River downstream area, and instrumental records on the downstream of the Hsiaolin Village indicated that 2.75 m drop during the period from 7:10 to 7:50 AM and 7.88 m rise during the period from 8:40 to 9:30 AM. Note that this evident water level changes in the Cishan River channel were observed at 27.8 km downstream of the Hsiaolin Village [44]. Total causality in Hsiaolin Village were more than 400 people dead and missing. The village itself no longer exists.
Hourly and accumulative rainfall for typhoon Morakot recorded by the Jiashan rainfall stations (11.4 km SSW of the Hsiaolin landslide) during the period from 6 Aug. to 11 Aug.
Figure 4 shows the Formosat-II image and aerial photos of the Hsiaolin landslide. According to the digital terrain models (DTMs) with a resolution of 5 m established by the aerial photos provided by the Agricultural and Forestry Aerial Survey Institute of Taiwan, Kuo et al. [7] indicated that the major body of the Hsiaolin landslide had the extent of 57 × 104 m2 and was estimated to have a volume about 24 ± 2 million m3, distributed at an average depth of 42 ± 3 m. Moreover, it is 3.2 km long in an E–W direction and 0.8 to 1.5 km wide. The total fall height was 830 m from the top of the head scarp, at an elevation of 1280 m, to the toe of the landslide deposit at 450 m [8]. Comparing the Hsiaolin landslide with the 1:25000 geologic map (provided by CGS, MOEA) shows that this landslide crops the late Miocene to early Pliocene Yenshuikeng Formation composed of mudstone, sandstone, and shale. Strength of sandstone is much greater than mudstone and shale, and its corresponding uniaxial compressive strength is about 15 Mpa [9]. The source area of the Hsiaolin landslide was the dip slope of the east limb of the syncline that could exhibits simple traces of strata on a horizontal cross-section, however, because the strata and slopes on the east region of the Cishan River shows the similar characteristics, the bedding traces have rather complicated patterns [8].
Formosat-II image and aerial photos of the Hsiaolin landslide in the Cishan River watershed, Taiwan.
A cascade of loose sediment produced by the Hsiaolin landslide deposited on the Cishan River and generated the barrier lake that was suddenly broken about 1 to 2 hours after its generation. The landslide dam was estimated to have a volume of 15.4 million m3. This is clear that only half of the total sliding mass contributed to the main body of the landslide dam [10]. The maximum elevation produced by this catastrophic landslide is about 475 m, on the west bank of the Cishan River and the maximum water level that can overtop the dam crest is about an elevation of 413 m. The height of the dam was about 44 m and the deepest deposit was a thick of 60 m. Moreover, this dam drained about 354 km2 watershed area and trapped about 9.9 million m3 water before overtopping occurred [10]. On the basis of data recorded by continuous river stream gauging from Shanlin Bridge station, the water level of the Cishan river dropped to 118 m nearly at 08:00 AM after the landslide dam formation and rapidly rise up to 126 m at about 9:40 AM [11]. Hence, we can infer that the landslide dam was suddenly flushed out by river water after the dam formation during the period of only 2 hours.
On August 8, 2009, Typhoon Morakot was “born” at approximately 22.4°N and 133.8°E in the North Pacific Ocean, about 1000 km far from Northeastern Philippines, moving west at a speed of 10–30 km/h towards Taiwan. In retrospect, Typhoon Morakot had not been considered a serious threat before striking Taiwan. However, contrary to the prediction, after landing Taiwan, it caused more damage than any other typhoon because of massive rainfall, especially in Taiwan’s southwestern region. Figure 5 shows the spatial distribution of rainfall in Taiwan for the six-day rainfall during Typhoon Morakot. This “monster “brought significant rainfalls causing severe debris flows, shallow and deep landslides, and debris dam-break in the mountainous areas of the central and southern Taiwan. Consequently, 675 people were dead; 34 people were hurt; the economic loss was up to 164 million NT dollars.
Spatial distribution of rainfall in Taiwan for Typhoon Morakot during six days.
Figure 6 shows the time series of hourly rainfall data and cumulative rainfall during Typhoon Morakot obtained from Alishan station in central Taiwan. On the basis of this hourly rainfall data, the maximum 1-hour, 6-hour, 24-hour, 48-hour and 72-hour rainfall near the headwaters of the Cishan River watershed were 123 mm, 549 mm, 1623 mm, 2361 mm and 2748 mm, respectively. Both the previous 1-hour (113 mm by Typhoon Herb) and 48-hour (1978 mm by Typhoon Herb) rainfall records were broken. The 24-hour and 48-hour rainfall records approximate the world record (1825 mm and 2476 mm, respectively) [12], as shown in Figure 7. Moreover, the return periods for 24-hour, 48-hour, and 72-hour rainfall at the Alishan station both exceeded 2000 years (WRA, 2010). Totally, Typhoon Morakot released about 3063 mm rainfall depth during 6 days. This total value is equivalent to about 90% of the annual rainfall in 2009 at Alishan station. In comparison with other typhoon storms, the magnitude of rainfall brought by Typhoon Morakot is quite huge as shown in Figure 8. These patterns indicate that this rainfall event can be characterized as high intensity, huge total accumulation and long duration in a large scale, and hence had generated severe hillslope erosion (e.g., landslides) in watersheds.
Time series of hourly rainfall amount and its accumulative rainfall from Aug. 6th to the end of Aug. 8th in 2009. This rainfall data is obtained from the records of the Alishan station.
Diagram of rainfall depth-duration for Typhoon Morakot at the Alishan rainfall station near the Cishan River watershed in comparison with the maximum rainfall records in the world.
Cumulative rainfall in relation to its corresponding rainfall duration for different typhoons obtained from the records of Alishan rainfall stations.
Taiwan has total landslides of 45,172 after the massive rainfall brought by Typhoon Morakot, ranging from 258 m2 to 3,510,861 m2 with an average of 12,488 m2 (Figure 9). These landslides were identified and mapped from the fused Formosat-II images having resolutions of 2 m, with detailed field checking, and then were digitized into a geographic information system (GIS). Via the fused Formosat-II images (in 2008 and 2009), a pair of successive landslide inventories were mapped through the normalized difference vegetation index (NDVI). The NDVI data are helpful in determining the density of green planet presence via the wavelengths difference. Mathematically, the NDVI is expressed as follows [13]:
where NIR is the near-infrared reflection and IR is the infrared reflection. These two reflections can be obtained by observing the different colors in wavelengths reflected by the plants. For landslide areas, the values of NDVI for a given pixel in the Formosat-II satellite images always range from −1 to 0.
Location of landslides in Taiwan mapped after Typhoon Morakot. These 45,124 landslides range from 258 m2 to 3,510,861 m2, with an average of 12,488 m2.
As shown in Figure 9, the landslide areas after Typhoon Morakot mainly concentrate on southern Taiwan that contains the Cishan River watershed (CRW). Figure 10 shows the landslide area (see red colored regions in Figure 8) before (in 2008) and after (in 2009) Typhoon Morakot. In contrast, the total landslide area increased from 7.83 km2 to 33.98 km2 and the landslide density increased from 5.7 × 10−3 no./ha to 28.4 × 10−3 no./ha (total number of landslide/survey area) after the disturbance of Typhoon Morakot. On average, the mean landslide area is 0.012 km2, ranging from a smallest area of 0.12 m2 to a maximum value of ~2.49 km2. These patterns indicate that Typhoon Morakot caused severe disturbances on the Cishan River watershed and could lead to significant changes in the geomorphic systems of this region, which we discuss later.
Landslide inventories mapped from a pair of Formosat-II satellite images in 2008 and 2009, respectively, for the Cishan River watershed. (a) Pretyphoon image in 2008. (b) Posttyphoon image in 2009.
In addition, landslide rank against cumulative landslide area can exhibits the contribution of different landslide magnitude to erosion processes. In this investigation region, landslides were ranked in a series of numbers from the smallest area (No. 1) to the largest area (No. 2338), as shown in Figure 11. As a consequence, the largest 10 landslides (0.43% of total number) account for 27% of total landslide area, the largest 58 landslides (2.5% of total number) account for 50% of total landslide area, and the largest 649 landslides (27% of total number) account for 90% of total landslide area. This result indicated that large landslides can majorly dominate denudation processes in the CRW.
Cumulative percentage of landslide area against to the ranking numbers of 2338 landslides identified after typhoon Morakot in 2009 in the CRW. These landslides were ranked in a series of numbers from the minimum area (no. 1) to the maximum area (no. 2338). The cumulative area of the first 58 largest landslides accounts for 50% of the total landslide area while the first 649 largest landslides for 90% of the total landslide area.
These landslide data were further analyzed by using a fractal model. The dependence of landslide frequency on landslide magnitude is an aspect of critical importance to hazard risk assessment and management [14]. Based on the analysis of landslide inventories in worldwide regions, frequency distributions and PDFs (probability density functions) exist in landslide magnitude with heavy tail for medium and large landslides. The mathematical expression of this algebraic PDF right tail decay is generally explained as a linear fitting for power-law scaling [15, 16, 17, 18, 45, 46]. Here we characterize the noncumulative frequency-area relations to clarify the landslide behavior in the CRW.
The present paper now considers the noncumulative relation as:
where
Noncumulative landslide frequency–area distributions in the CRW, based on landslide data after typhoon Morakot in 2009. The landslides of area larger than 645 m2 display a fractal model with
This phenomenon is described by self-organized criticality (SOC). Bak [19] indicates that if a system is well described by power-law scaling over a large portion of its event magnitude range, the system may be in a quasi-static state with SOC. In the CRW, landslides caused by Typhoon Morakot satisfies (2) with
Region | α | β |
---|---|---|
Japan [20] | 0.89 | 1.89 |
Western Southern Alps, New Zealand (Hovius et al., 1997) | 1.1 | 2.1 |
Challana Valley, Bolivia [21] | 1.6 | 2.6 |
Alameda, USA [21] | 2.3 | 3.3 |
Umbria, central Italy [22] | 1.5 | 2.5 |
California, USA [22] | 1.3 | 2.3 |
Lombardy, northern Italy [23] | 0.85 | 1.85 |
Southern California, USA [24] | 1.1 | 2.1 |
Fiordland, New Zealand [25] | 1.07 | 2.07 |
Val di Fassa, Italy [26] | 1.56 | 2.56 |
TWR and CYL watersheds, Taiwan [18] | 0.65 | 1.65 |
CRW, Taiwan | 0.69 | 1.69 |
Exponent values of fractal model for landslide frequency-area distribution collected form the worldwide observations.
Landslides tend to occur in groups. Occurrence of landslides on hillslopes is therefore influenced by the geomorphic characteristics of subaerial surface because some geomorphic condition can provide suitable environments for the development of landslide. Hence, the investigation of landslide abundance and its corresponding spatial distribution in relation to the factors in situ is necessary for landslide hazard assessment. Here we used 5 × 5 m digital elevation model (DEM) (provided by Water Resources Agency, WRA) to analyze different geomorphic settings such as elevation, slope, aspect, surface residual, surface curvature, and fractal dimension in the CRW. Also, the distribution of lithologic complexes was obtained from the geological map provided by the Center of Geological Survey, Taiwan. These above mentioned factors were examined with the location of landslide triggering in the CRW, as tabulated in Table 2.
Classification | ||||
---|---|---|---|---|
Elevation | 0–500 | 0.52 | 2.89 | 1.17 |
500~1000 | 1.47 | 8.19 | 11.74 | |
>1000 | 2.67 | 14.89 | 6.92 | |
Aspect | North | 0.47 | 2.62 | 4.65 |
Northeast | 0.51 | 2.83 | 6.75 | |
East | 0.62 | 3.43 | 6.64 | |
Southeast | 0.70 | 3.91 | 5.95 | |
South | 0.57 | 3.15 | 4.43 | |
Southwest | 0.68 | 3.76 | 4.91 | |
West | 0.63 | 3.50 | 4.26 | |
Northwest | 0.49 | 2.76 | 3.56 | |
Slope gradient | S < =5% | 0.01 | 0.07 | 0.09 |
5% < S < =15% | 0.08 | 0.42 | 1.06 | |
15% < S < =30% | 0.31 | 1.72 | 2.49 | |
30% < S < =40% | 0.46 | 2.55 | 4.29 | |
40% < S < =55% | 1.11 | 6.21 | 6.89 | |
55% < S < =100% | 2.45 | 13.67 | 8.05 | |
S > 100% | 0.23 | 1.30 | 7.07 | |
Geologic settings | Loam | 0.08 | 0.45 | 0.76 |
Slate | 0.13 | 0.75 | 25.45 | |
Interbedded slate and sandstone | 0.08 | 0.43 | 3.05 | |
Interbedded sandstone and shale | 4.07 | 22.67 | 6.00 | |
Hard sandstone | 0.13 | 0.73 | 4.46 | |
Hard shale | 0.17 | 0.92 | 3.35 | |
Gravel | 0.00 | 0.02 | 0.09 | |
Curvature | Convex | 1.98 | 11.03 | 4.40 |
Flat | 0.08 | 0.42 | 1.57 | |
Concave | 2.60 | 14.50 | 5.71 | |
Surface roughness | 0~0.3 | 1.50 | 7.99 | 4.71 |
0.3~0.6 | 2.03 | 10.81 | 5.19 | |
0.6~0.9 | 0.80 | 4.28 | 4.46 | |
0.9~1.2 | 0.23 | 1.25 | 4.45 | |
1.2~1.5 | 0.03 | 0.15 | 3.17 | |
1.5~1.8 | 0.00 | 0.02 | 6.54 | |
2~2.2 | 0.00 | 0.03 | 1.61 | |
Fractal dimension | 2.2~2.4 | 2.47 | 12.96 | 6.43 |
2.4~2.6 | 2.02 | 10.58 | 4.91 | |
2.6~2.8 | 0.08 | 0.42 | 0.66 | |
2.8~3 | 0.003 | 0.02 | 0.09 |
Landslide distribution in response to geomorphic and geologic settings in the CRW.
The percentage of landslide area (
As shown in Table 2, landslide distributed in the different geomorphic and geologic settings cropping out CRW after Typhoon Morakot. The largest elevation group in the CRW is the region lower than 500 m that extends 44% of total watershed area. This region only cropped out
On the basis of the Soil and Water Conservation Technical Guide issued from Taiwan government, the terrain gradient in the CRW can be categorized into seven classes as well as shown in Table 2. In this watershed, the hillslopes are most widely mantled by the sixth-class slope gradient (between 55% and 100%, i.e., between 28.8° and 45°; see Table 1), with 32.9% of the total watershed area (842 km2) and has the greatest values for landslide density (13.67 No./km2) and landslide rate (7.45%), respectively. In other words, the smallest unit is the gradient of hillslopes less than 5% (i.e., 2.86°) and therefore has the lowest values for landslide density of 0.07 No./km2 and landslide rate of 0.09%. Aspects of hillslopes were also classified into eight groups (Table 2). It is clear that there are no evident differences in each hillslope aspect that accounts for about 8–15% of the total watershed area. The largest unit is west-facing slopes that extends 15.33% of the 843 km2 CRW area, with the quite small values of landslide density (3.5 No./km2) and landslide rate (4.68%). Of particularly, landslides in the CRW after Typhoon Morakot cropped out the similar values of
The above mentioned geomorphic characteristics are usually used to be as landslide triggers, and to examine landside occurrence in response to geomorphic systems. However, those geomorphic characteristics are simple and using those characteristics (i.e., elevation, slope and aspect) could not represent complex geomorphic systems in natural environments, e.g., convergent slopes and surface roughness. To consider the complexity of geomorphic conditions, we employed curvature, surface roughness and fractal dimension, comparing with the location of landslide occurrence to find out the ‘hotspot’ or ‘prone area’ in the CRW.
Curvature is the changing rate of slope along
Here we define the surface roughness is a residual topography that can be derived from the cell by cell subtraction of original 5 × 5 m DEM and the mean of this DEM. Mean DEM was created by averaging elevation values within a 3-cell moving window. The raster of residual topography was then calculated as the cell-by-cell difference between the original DEM and the mean DEM. In the Cishan River watershed, surface roughness (i.e., residual topography) was calculated as the above mentioned flow and further categorized into six groups by 0–0.3, 0.3–0.6, 0.6–0.9, 0.9–1.2, 1.2–1.5 and 1.5–1.8. Based on this classification, the largest unit of surface roughness is the region of the values from 0.3 to 0.6 that covers about 39.32% of the total CRW area, with 10.81 landslides per km2 respect to this region. Note that there is no significant difference between landslide rates in each surface roughness settings, ranging from 3.07% to 6.14%. These patterns suggest that landslides tend to be triggered in group in the region of surface roughness between 0 to 0.6. Above this cutoff, the landslide density and landslide rate evidently decrease as well as shown in Table 2.
In other words, natural landscapes generally have fractal characteristics. Terrain can be considered self-similar in the two horizontal directions and self-affine in cross-section [30]. This leads to the discussion of the relationships of landslide triggering with respect to the self-similarity or fractals of topography be necessary. Fractal dimension in the CRW was calculated using the Landserf software on the basis of 5 × 5 m DEM, comparing with the location of landslide occurrence. Landserf implements the variogram method (e.g., [31]), which we use in this study. The variogram is calculated as:
where
In general, Geologic settings determine the strength of rocks that can further influence sediment production caused by weathering processes on hillslopes. Soft rock can usually lead to weak resistance to erosion. Based on geologic map provided by Central Geological Survey, MOEA, Taiwan, we can find that the largest geologic unit is interbedded sandstone and shale, cropping out about 72% of the total CRW area. We also examined landslide distribution in response to geologic settings. Results show that percentage of landslide area
The geologic setting crops out interbedded sandstone and shale that has weak, low resistance to erosion and lies most regions of the CRW, favoring the generation of landslides on hillslopes.
The above landslide inventory shows that landslide triggering can be influenced by geomorphic and geologic settings. The hillslope with elevation of 500 m, slope between 28.8° and 45°, convex slopes, surface roughness index from 0 m to 0.6 m, fractal dimension from 2.2 to 2.6 and geologic unit composed of sandstone has high potential for the development of landslides.
Denudation processes play a very important role in the fluvial systems of a watershed. A large amount of sediment materials produced by landslides could be entrained downslope from hillslopes into river channels, influencing the evolution of river morphology. Typhoon Morakot led to severe hillslope erosion in the CRW (Figure 8), and its consequent generation of sediment materials could deposit on hillslopes and river channels, changing the geomorphic response of the CRW. Here we compared the river borne suspended sediment and river bathymetry of the Cishan River to show the aftermath effect of Typhoon Morakot on the CRW.
River-borne suspended sediment is an important feature of the global denudation system and is often adopted as a measure of terrestrial erosion rates and the intensity of erosion processes in watersheds [32, 33]. Here we quantitative the impact of Typhoon Morakot on the sediment loads of Cishan River by using the measurement of suspended-sediment discharge of Shenlin-bridge river stage station from 1987 to 2005 and 2010 (no measurement from 2007~2009). The water discharge is daily recorded, and the sediment concentration is measured fortnightly using a USDH-48 suspended-sediment sampler from the Water Resources Agency of Taiwan. Evaluating the amount of sediment loads can use the formula of rating curve based on water discharges. Fitting the plots of suspended-sediment discharge on log-log scale using least square can obtain an equation as
where
Figure 13 shows the river-borne suspended-sediment rating curves of the Cishan River on the basis of data recorded by the Shanlin Bridge gauge. The power-law relation of measurement data before Typhoon Morakot (from 1987 to 2005; see red line) fitted by least-square regression is expressed as
and the relation of that after the typhoon events (in 2010; see black line) fitted by least-square regression is expressed as
Suspended-sediment rating curves for the Cishan River. Red circles show measurements made before Typhoon Morakot; blue circles show measurements after the typhoon storms. Dashed lines are power-law relations fitted to pretyphoon data using log-transformed least-squares regression; solid lines are power-law relations fitted only to posttyphoon data.
According to (5) and (6), change in unit sediment concentration for the Cishan River after Typhoon Morakot is equivalent to 10 (i.e., △
Here we calculated the annual river-borne suspended-sediment loads via the estimates of the rating curve for the Cishan River that combines the relationship of suspended-sediment concentration with respect water discharges, with the instrumental records of daily water discharges. In addition, we estimated the suspended-sediment loads driven by Typhoon Morakot for the Cishan River by the rating curve regression employing 4 successive daily water discharges at the beginning of 6 Aug. Note that all the records of daily water discharges were obtained from the Shanlin Bridge gauge.
Figure 14 shows the mean annual sediment load,
Mean annual sediment loads,
In general, in mountain belts, sediment produced by storm-triggered landslides usually rapidly transfers into the fluvial systems and could not taking a long time to storage on hillslopes. However, we have shown a large amount of sediment materials deposited on hillslopes at the end of 2010 after Typhoon Morakot in the above section. Landslides caused by Typhoon Morakot supplied magnificent sediment to the Cishan River and could lead to sedimentation in the river channels. Here we collected the elevation data for the 62 cross section of the Cishan River, from Jiashian weir to Erren-Yuemei weir and the river reach is shown in Figure 15, which was reported by Water Resources Planning Institute [34].
Formosat-II images of river reach with 62 cross section measurement for the Cishan River from Jiashiang weir to Erren-Yuemei weir.
The longitudinal profile is a continuous line by the lowest elevations at each stream cross sections. Figure 16 shows the longitudinal profile of this 22.8 km river reach for the Cishan River, illustrated by the measurement data of each stream cross section during the periods of pretyphoon (in 2005) and posttyphoon (in 2010). Result indicates that the riverbed has a slight scour cumulative distance of below 1 km and above 18 km for the original cross section No. 22, respectively, but other reaches had significant sedimentation. To quantitative the effect of changes in the riverbed on the transport capacity for this river reach (Figure 15), the unit stream power [35] was used as
where
replacing the
Longitudinal profiles of river reach for the Cishan River from Jiasiang weir to Erren-Yuemei weir obtained from the elevation data of pretyphoon and posttyphoon measurement.
Of particular interest, (9) infers that unit stream power could be only influenced by changes in the gradient of riverbed, because water density and water discharges could be treated as the same values in the same stream reach. Hence, based on (9), we can only examine the gradient of riverbed pretyphoon and posttyphoon to describe shifts in unit stream power for the river reach as shown in Figure 16. Calculating the gradient of longitudinal profile for the river reach form the measurement data in situ show that the pretyphoon riverbed gradient (in 2005) was 2.8% and the posttyphoon riverbed gradient (in 2010) was 1.3%, respectively. This indicates that unit stream power for the Cishan River had been significantly decreased (about 55%) after the disturbance of Typhoon Morakot and could lead to the lowering of transport capacity for the fluvial system, increasing sedimentation on the riverbed.
In other words, the longitudinal profile for the river reach is further separated into four parts with the cumulative distances of ~5 km, dissecting shifts in the unit stream power the river channels influenced by Typhoon Morakot. Figure 17 shows the variations in the gradients of the riverbed calculated by the pretyphoon and posttyphoon measurement data in situ. Before the typhoon disturbance in 2005, the gradients of the riverbed were 0.00794, 0.00539, 0.00586 and 0.00705 for the upstream to the downstream, indicating that unit stream power in the river reach gradually decreased along the longitudinal river profile and had an increase in the riverbed gradient approximating the Erren-Yuemei weir. Sedimentation in the river channel was elevated by TypvMorakot, leading to reduction in its riverbed gradient and lowered about 10, 7, 29 and 7% of unit stream power for those four river reaches from the upstream to the downstream. These patterns suggest that significant sedimentation processes can be observed in this reach for the Cishan River, because the lowering of river transport capacity and abundant sediment supplied from the hillslopes in the CRW after Typhoon Morakot. Hence, the increased likelihood of flood inundation in the reach of the Cishan River (Figure 14) are expected due to its elevated riverbed.
River gradients of four reaches along the Cishan River from Jiasiang weir to Erren-Yuemei weir before and after the disturbance of Typhoon Morakot.
Sediment sources produced by Typhoon Morakot was richly supplied from hillslopes to the fluvial system, elevating the riverbed of the Cishan River. This elevated riverbed lowered the unit stream power of the river channel and could lead to water flow centrally erode the riverbanks. To investigate changes in the riverbanks for the Cishan River, we used a pair of Formosat-II images to digitalize the pretyphoon (in 2008) and posttyphoon (in 2009) edges of the riverbanks within GIS. Then, HEC-RAS was used to extract the river widths per 100 m along the river channel before and after the disturbance of Typhoon Morakot. Figure 18 shows the box-whisker plot of the river widths estimated from pretyphoon and posttyphoon data for the Cishan River. The second and third quartiles of the pretyphoon river widths are ~110 and 190 m, respectively, with a maximum of 728 m, a minimum of 16 m, and an average of 144 m. However, after the typhoon disturbance, the Cishan River widths were evidently widened and had the second and third quartiles of 260 and 471 m. Its maximum and minimum river widths were shifted into 2090 and 17 m, with an average of 342 m. This is clear that river widths increased by more than a factor of 2 to those statistical estimate values before the hit of the typhoon. Results show that Typhoon Morakot caused severe riverbank erosion for the Cishan River, leading to its consequent river width widening.
Box and whisker plot of river widths along the Cishan River estimated from pretyphoon and posttyphoon mapping based on a pair of Formosat-II images in 2008 and 2009, respectively.
Comparing these two river channel inventories (in 2008 and in 2009) can show changes in river widths caused by Typhoon Morakot. Subtraction between the pretyphoon and posttyphoon river widths in each river cross section indicates that only about 22 cross sections display contracting adjustment, i.e., the river widths in 2009 smaller than that in 2008, only accounting for 1.6% of total 1357 cross sections. Most of the river widths show widening adjustment after the typhoon disturbance. Here we focused on the widening adjustment of the 1335 cross sections for the Cishan River in 2009. Also, we characterized the noncumulative frequency-widening relations to clarify whether the river widening has a SOC phenomenon. The noncumulative frequency distribution of river widening can be mathematically expressed as
where
Noncumulative frequency distribution of river width widening after Typhoon Morakot for the Cishan River. Above the cutoff of 64 m, the river width widening satisfies a power-law relation with exponent β = 1.93.
Of particular interest, the
In this chapter, we characterize landslides triggered by Typhoon Morakot in 2009, and its corresponding frequency-area distribution. Results show that the exponent value of a noncumulative relation for these landslides approximates the lowest limitation of worldwide observation. This infers that the hillslopes of the CRW has high potentials on landslide triggering. Meanwhile, ambient sediment materials produced by landslides could deposit on hillslopes and river channels and cause the adjustments of hillslope and fluvial systems, which can be observed from raised river-borne suspended-sediment concentration in the Cishan River (i.e., rich-supply hillslopes) and its decreased stream power (severe sedimentation in river channels). These patterns indicate that landslides not only pose threats to people’s life and properties, but also have significant influence on the downstream. Hence, long-term and short-term strategies for landslide countermeasures are both necessary. The long-term strategies are the comprehensive management and regulation of basins and watersheds. The short-term strategies are the development of real-time warning systems for landslide triggering on hillslopes. In Taiwan, the present real-time warning system developed for landslide hazards are described as follow.
Before hit by this typhoon storms, the Central Geological survey, MOEA (2009) in Taiwan has used logistic equation to estimate landslide ratios via the potential values obtained from the combination of 100-year return period hourly rainfall depth and cumulative daily rainfall to map the landslide susceptibility. On the basis of this susceptibility, Taiwan’s hillslopes were categorized in three regions of high risk, medium risk and low risk. Comparing with the location and initiation time in situ of landslides or rock avalanching (total of 909; provided by Soil and Water Conservation Bureau and Central Geologic Survey) show that these geomorphic erosion processes crop out the regions of high risk ~43% of totals. 90% of total can be observed when we consider both of high risk and medium risk regions. However, although the construction of landslide susceptibility can provide some useful information on mapping landslide-prone areas, the effect of real-time rainfall during typhoon storms should be necessary for landslide warning, still. Considering only landslide-prone area could also lead to the over-issued orders of hazard mitigation from landslide warning and also the wasting of governmental administrative resources.
Rainfall brought by typhoon storms plays a majorly important role in triggering landslides on hillslopes. Typically, some topographic and geologic regimes could provide suitable conditions for landslide triggering but landslides are still needed to be initiated by external triggers such as rain infiltration and its consequent saturation. The evolution of soil pore pressure can be mainly influenced by these triggers, leading to the change of normal and shear stresses for a soil profile, further reducing slope failure [36, 37]. Many researchers have investigated landslide and debris flow triggering in response to different rainfall parameters [18, 38, 39, 40, 42, 43], showing that different rainfall characteristics can affect the initiation of debris flows and landslides from place to place. The precise relationship between landslides and rainfall parameters remains unclear, leading to the need of studies on the characteristics of rainfall-triggered landslides on hillsides in different regions [18].
To analyze the relationships of landslide triggering with respect to rainfall characteristics, Jan [41] collected 15 landslide inventories for different periods, comparing with its corresponding different rainfall parameters that include 3-hour average rainfall intensity
Effective accumulative rainfall (Rt) against 3-hour average rainfall intensity (
In Taiwan, the rainfall-threshold warning system is well constructed for debris flow mitigation. Referring the rainfall parameter considered in the warning system for debris flow mitigation and the above mentioned works, Jan [41] has proposed a rainfall-threshold index for landslide mitigation as follow:
where
Level 2 warning would be released when the values of real rainfall data gauging is higher than
Level 1 warning would be released when the values of real rainfall data gauging during a 3-hour period is simultaneously higher than
Level 1 warning would be reduced to Level 2 when the values of real rainfall data gauging during a 3-hour period is simultaneously lower than
Level 2 warning would be left when the values of real rainfall data gauging during a 3-hour period is simultaneously lower than
This rainfall-induced, shallow landslide warning system is used to provide information on the decision making of landslide hazard mitigation for Soil and Water Conservation Bureau of Taiwan.
Severe typhoon storms and the consequent landslide hazards on hillslopes have frequently posed threats to economic implementation whose impacts on the wealth and property may exhaust the available resources to deal with the aftermath of those disasters. In Taiwan, the countermeasures of debris flow have been well developed in recent 20 years, gradually. However, the development of shallow landslide mitigation measures and warning systems are still limited and should be emergent in the future. Moreover, it must need to strengthen public awareness of landslide hazards, educating people on how to respond to landslide hazards on hillsides, especially during rainy seasons. Meanwhile, more research on landslide mechanics, warning system, and its corresponding rationale prediction and assessment methods are necessary.
Occurrence of landslides on hillslopes is not only a real challenge of natural hazard mitigation, but also river channel management. As we above mentioned, ambient Typhoon Morakot had led to significant sedimentation in the Cishan River and the dredging of river channels therefore becomes an important issue after the typhoon disturbance on landscapes. Landslide triggering can simultaneously influence the evolution of hillslope and fluvial systems, leading to its regulation should be integrated and consistent. Hence, Compound-disaster perspective and its domino effect on each disaster are necessary to be considered in the development of landslide countermeasures. In addition, for disaster evaluation in the case of emergency, satellite images, aerial photography and field survey immediate after typhoon storms are necessary to construct high resolution digital topography models that can be used in the aftermath analysis and modeling. Also, more fruitful research on the understanding of landslide mechanics, from which we can develop appropriate design codes in building and installing sediment-control structures, are pressingly needed in Taiwan.
This work was supported by the Ministry of Science and Technology in Taiwan under the Grant No. MOST 104-2221-E-006 -053 -MY3 and MOST 106-2625-M-006-018 -. The writers sincerely appreciate the help of Y.C Wang in digitalizing the widths of the Cishan River.
Cancer is a complex, severe class of diseases that involves a group of cells that exhibit abnormal and uncontrolled division and proliferation. It is one of the primary health concerns which accounts for the second major cause of death globally. As per the recent statistics of the world health organization (WHO), in 2020, around 10 million people succumbed to death due to cancer. However, every year the number of incidences is increasing day by day. According to WHO, around 0.3 million new cases are diagnosed each year among the age group of 0–19 years. Cancer can affect a person of any age; however, with age, the risk increases. Globally, steady increases in cancer cases every year are taking a toll on the health care system [1, 2, 3, 4, 5]. To combat cancer, identification of potential drugs and potential drugs combination is essential. Potential research has been carried out to counter such problems by addressing novel drug design and discovery approaches. In medicinal chemistry, heterocyclic rings have played a significant role in the search for potential therapeutic agents. Various drugs are currently in use and in development that widely addresses such problems. However, due to changes in cancer forms and mutations, current therapy faces challenges of poor selectivity and specificity towards certain types of cancer cells, which narrows down their effectiveness. Generally, cancer cells act by disrupting and disturbing the cell signaling pathways; therefore, it is crucial to design novel target-based heterocyclic anticancer compounds with high efficacy and fewer side effects, which will provide a solid backup to the present chemotherapeutic regime [6, 7, 8, 9, 10].
Benzimidazole is a bicyclic nitrogen bearing aromatic heterocyclic ring, structurally it consists of benzene ring fused with imidazole ring at the 4th and 5th position of the ring. Chemically it appears as white crystals, amphoteric in nature, resembles the structure of purine. It is synthesized by different reported methods. However, condensation of 1,2-diamino benzene with carbonyl compounds to give benzimidazole is the conventional method which was used widely for its preparation. In 1858, it was synthesized by Heinrich Debus, a German chemist from glyoxal, ammonia and formaldehyde, that’s why it was also known as glyoxalin. Benzimidazole ring is one of bioactive heterocyclic scaffold exhibiting wide range of biological activities. The ▬NH group present at second position of the ring is both highly acidic and weak base in nature, it also has ability to form stable salts [11, 12, 13, 14, 15, 16].
With time benzimidazole ring emerged as an important multifaceted heterocyclic system due to its wide range of pharmacological activity such as antibacterial [17], antiparasitic [18], antifungal [19], anti-inflammatory [20], analgesics [21], antiviral [22], antitubercular [23], anticoagulant [24], antihistaminic [25], antioxidant [26], antiulcer [27] and anticancer [28, 29, 30, 31]. Some of the benzimidazole based marketed drugs are listed in with their indication and marketed name in Figure 1. Adding to this benzimidazole scaffold have also displayed a significant role in synthesis of organic intermediates. In light of the application of benzimidazole earlier various authors have reported many review articles. Due to the diverse therapeutic potential, benzimidazole have attracted lot of researchers to explore more in the field of drug discovery to synthesize novel and potent compounds with a broad spectrum of biological activities. Owing to this, with time efforts have been made to create libraries of these potent compounds. In cancer treatment benzimidazole based drugs played a significant role, various targeted therapies are designed and developed as Kinase inhibitors such as EGFR, VEGFR and PI3K inhibitors here, in this chapter we have included some potent benzimidazole based kinase inhibitors.
Examples of benzimidazole based drugs in clinical use.
Benzimidazole based compounds have got much attention due to exhibiting significant cytotoxic activity. In last one decade a lot of benzimidazole based anticancer drugs have received status of US FDA global approval. Recently, Binimetinib, Selumetinib and Abemaciclib got approval for treatment of various mutated forms of cancer. Here, we have discussed some of benzimidazole based anticancer drugs which are recently approved, under development and in pipeline.
Binimetinib (
Benzimidazole based clinically approved anticancer agents.
Drug | Clinical trial number | Clinical trial study | Date of study | Current status and study phase |
---|---|---|---|---|
Binimetinib | NCT04965818 | Phase 1b/2 study of Futibatinib in combination with Binimetinib in patients with advanced KRAS mutant cancer | Last update on September 27, 2021 | Recruiting Phase 1b/2 |
NCT03170206 | Study of CDK4/6 inhibitor Palbociclib in combination with the Binimetinib for patients with advanced KRAS mutant NSCLC | Last update on June 10, 2021 | Recruiting Phase 1 | |
Bendamustine | NCT04217317 | CPI-613 in combination with Bendamustine in patients with relapsed or refractory T-cell Non-Hodgkin lymphoma | Last update on August 30,2021 | Recruiting Phase 2 |
NCT04510636 | Study of Pembrolizumab with Bendamustine in Hodgkin lymphoma | Last update on August 30,2021 | Not yet Recruiting Phase 2 | |
Selumetinib | NCT02768766 | Intermittent Selumetinib for uveal melanoma | Last update on March 19, 2021 | Recruiting Phase 1 |
NCT05101148 | Phase I study to assess the effect of food on the PK and gastrointestinal toxicity of Selumetinib in adolescent children with Neurofibromatosis Type 1 related plexiform neurofibromas | Last update on November 1, 2021 | Recruiting Phase 1 | |
Abemaciclib | NCT04003896 | A study to evaluate Abemaciclib in advanced biliary tract carcinoma who failed prior first line therapy. | Last update on | Active, Not recruiting Phase 2 |
NCT04040205 | Abemaciclib for bone and soft tissue sarcoma with cyclin dependent kinase (CDK) pathway attention | February 15, 2021 | Recruiting Phase 2 | |
Veliparib | NCT02723864 | Veliparib and VX-970 in combination with cisplatin in people with refractory solid tumors | Last update on February 5, 2021 | Active, Not recruiting Phase 1 |
NCT01434316 | Veliparib and Dinaciclib in treating patients with advanced solid tumors | July 20, 2021 | Recruiting Phase 1 | |
Dovitinib | NCT01635907 | Dovitinib in neuroendocrine tumors | Last update on April 14, 2020 | Completed Phase 2 |
Pracinostat | NCT03848754 | Pracinostat and Gemtuzumab ozogamicin in patients with relapsed or refractory acute myeloid leukemia | Last update on October 18, 2021 | Active, not recruiting Phase 1 |
Galeterone | NCT04098081 | Galeterone with Gemcitabine for patients with metastatic pancreatic adenocarcinoma | Last update on March 10, 2021 | Recruiting Phase 2 |
Nazartinib | NCT02335944 | Study and safety and efficacy of Nazartinib in combination with cMET inhibitor INC280 in NSCLC patients with EGFR mutation | Last update on October 4, 2021 | Active, not recruiting Phase 1/2 |
NCT02108964 | A phase I/II, multicentre, open label study of Nazartinib, administered orally in adult patients with EGFR mutated solid malignancies | Last update on August 13, 2021 | Active, Not recruiting Phase 1/2 |
Benzimidazole based anticancer drugs in clinical development.
Bendamustine (
Selumetinib (
Abemaciclib (
Veliparib (
Dovitinib (
Pracinostat (7) is chemically (E)-3-(2-butyl-1-(2-(diethyl amino) ethyl)-1H-benzoimidazol-5-yl)-N-hydroxyacrylamide, it is orally available, investigational drug exhibiting potential antitumor activity [49, 50]. Pracinostat is a small molecule next generation histone diacetylases (HDAC) inhibitor indicated acute myeloid leukemia [51]. In some recent study Pracinostat was found to suppresses growth and metastasis of breast cancer by inactivating the IL-6/STAT3 signaling pathway [52].
Galeterone (
Nazartinib (
Commonly the mechanism behind action of anticancer agents involve DNA intercalation, gene regulation, microtubule inhibition, transcription regulation, DNA synthesis inhibition, enzyme inhibition and so on. Nowadays in cancer treatment, target therapy emerged as one of the acknowledged strategies. Most of the available anticancer drugs acts by targeting structural proteins, tyrosine kinases, phosphoinositide 3 kinase and protein kinases for example Binimetinib acts by inhibiting mitogen activated kinase as discussed in earlier section. In this section we have included some recent examples of benzimidazole based enzyme inhibitors as potent anticancer agents.
Akhter et al. have reported a novel series of benzimidazole based oxadiazole derivatives as potential EGFR inhibitors. The target compound
Srour et al. have reported a novel series of thiazole benzimidazole derivatives as potent inhibitor of EGFR tyrosine kinase. Target compound
Akhter et al. have reported as series of pyrazole benzimidazole derivatives as potential inhibitors of EGFR. Target compound
Examples of benzimidazole derivatives as potent EGFR inhibitors.
Abdullaziz et al. have reported a novel series of 2-furybenzimidazole derivatives as potent inhibitors of VEGFR-2 kinase. Target compound
Lien et al. have reported novel 2-aminobenzimidazole derivative
Recently Yuan et al. have designed and synthesized a new series of benzimidazole derivatives as potent and selective inhibitor of VEGFR-2 kinase. Target compound
Examples of benzimidazole derivatives as potent VEGFR-2 inhibitors.
Meguid et al. have reported a novel series of benzimidazole derivatives as potent dual inhibitors of EGFR and VEGFR-2 kinases. Target compound
Kassab et al. have reported novel quinazoline bearing benzimidazole derivatives as potential inhibitors of EGFR and VEGFR-2 kinases. Target compound 22 displayed excellent inhibitory activity against EGFR kinase with an IC50 value of 127.4 μM, whereas it displayed an IC50 value of 185.7 μM against VEGFR-2 kinase. Further, cytotoxicity study of compound against MCF7 cancer cell line demonstrated good potency with IC50 value of 12.0 μM [66] (Figure 5).
Examples of benzimidazole derivatives as potent EGFR/VEGFR dual inhibitors.
GSK2636771 (
Jin et al. have reported novel benzimidazole derivatives as potent PI3K inhibitor. Target compound 24 was found most potent against PI3Kα with 36% and 86% inhibition compare to reference drug Alpelisib, which showed an inhibition of 110% and 109% at 50 nM and 500 nM respectively. Further, molecular docking analysis of target compound 24 demonstrated strong binding with six strong hydrogen bond with GLN-859, SER-854 and VAL-851 amino acid residues. Further, HUMO-LUMO calculation which is studied by using Gaussian 09 software target compound 24 showed presence of thiazole core and amide bonds which played an important role in its biological activity [69].
Recently a novel series of benzimidazole based dehydroabietic acid derivatives were reported Yang et al. as potent PI3Kα inhibitors. Target compound
Chanrasekhar et al. have reported a novel series of benzimidazole derivatives as potent PI3K inhibitors Target compound
Wu et al. have reported a novel series of triazine substituted benzimidazole derivatives a potent dual inhibitor of PI3K and mTOR, most of the compounds from the series displayed potent inhibitory activity with IC50 below 33 nM. Target compound
Shin et al. have reported a novel series of benzimidazole derivatives a potent inhibitor of PI3Kδ. Target compound
He et al. has reported benzimidazole-isoquinolinone derivatives which inhibits the cell growth via inhibiting PI3K/mTOR/Akt pathway. Target compound
Wu et al. have reported triazine bearing benzimidazole derivatives a potent inhibitor of PI3K and mTOR. Target compound
Examples of benzimidazole derivatives as potent PI3K inhibitors.
Ibrahim et al. have reported a novel series of flavopiridol-benzimidazole as potent inhibitor potent inhibitor of CDK2 and CDK9 kinase. Target compound
Examples of benzimidazole derivative as potent CDK inhibitor.
Pankaj et al. have reported a novel hybrid derivatives of benzimidazole-thiazolidinedione as potent cytotoxic agents. Target compound
Sivaramakarthikeyan et al. have reported novel hybrid derivatives of benzimidazole and pyrazole as potent anticancer agents. Compound 35 and 36 have demonstrated potent anticancer activity against selected human pancreatic cancer cell lines namely SW1990 and AsPC1 with an IC50 value in range of 30.9–61.8 μM respectively. Molecular docking study of both compound showed significant binding with the active site of B-cell lymphoma [78].
Mantu et al. have reported a novel series of benzimidazole-quinoline hybrid derivatives as potent anticancer agent. Target compound 37 exhibited potent antitumor activity against renal cancer cell line A498 and breast cancer cell line MDA-MB-468 with percentage growth inhibition of 52.92% and 56.54% respectively. Compound 37 also exhibited potent antitumor activity against leukemia cell line RPMI-8226 and non-small cell lung cancer cell line NCI-H23 with total growth inhibition of 35% [79].
Sharma et al. have reported benzimidazole-thiazolidinedione hybrid derivatives as potent anticancer agents. Target compound 38 and 39 displayed potent anticancer activity against cancer cell line with an IC50 value of in range of 0.13-10.24 μM against prostate cancer cell line PC-3, breast cancer (MDAMB-231), cervical cancer (HeLa), lung cancer (A549), and bone cancer (HT1080) cell lines. Both hybrid derivative 38 and 39 demonstrated significant inhibition of A549 cells migration through disruption of F-actin assembly, further treatment with 38 and 39 also showed increase in level of ROS in A549 cells by collapsing the mitochondrial membrane potential [80].
Bistrovic et al. have reported novel hybrid derivatives of benzimidazole-1,2,3-triazole as potent anticancer agents. Target compound 40 and 41 demonstrated excellent inhibitory activity with IC50 value of 0.05 and 6.18 against A549 cancer cell line and an IC50 value of 17.53 and 8.80 against HeLa cancer cell line respectively. Furthermore, apoptosis detection study by annexin assay of compound
Examples of benzimidazole containing hybrid derivatives as potent anticancer agents.
Many benzimidazole-containing compounds as anticancer agents are studied and available, involving various mechanisms in inhibiting mutated cancerous cells, in which kinases inhibitors play a significant role. However, in targeted therapy, benzimidazole-based derivatives are still widely explored. Due to the challenge of target specificity and poor selectivity, very few compounds have been approved to treat mutated cancers. The search for a novel benzimidazole-based next generation kinase inhibitor is going to subside such challenges. Benzimidazole-based target therapies such as enzyme inhibitors have gained a lot of attraction; owing to this, recently US FDA has approved EGFR inhibitor Abemaciclib and MEK inhibitor Binimetinib and Selumetinib as potent anticancer compounds against mutated forms of cancer. Apart from this, many benzimidazole-containing compounds are in the developmental phase as EGFR, VEGFR-2, CDK and PI3K inhibitors. However, some of the compounds demonstrated excellent kinase inhibitory activity but failed to provide a strong safety profile; these compounds will pave a path as lead compounds; further modifications, designing, and developing such compounds will give potent compounds with maximum efficiency and minimal side effects. The presented chapter mainly focuses on benzimidazole-based kinase inhibitors and their advances; the pivotal information catered here can be regarded as noteworthy and crucial by medicinal chemists for drug design, discovery and development of novel, potent and safe, target-based anticancer agents.
Authors wishes to acknowledge Jamia Hamdard (deemed-to-be-University) for providing support for conducting this study.
Authors declare “no conflict of interest.”
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Ovarian cancers are heterogenous cancers where each subtype possesses a varied morphology and biologic behavior. Accumulating evidence has identified each of these subtypes characterized with specific pathways activated in each along with specific gene alterations. For example, high-grade serous ovarian cancer is characterized by universal TP53 mutation, mucinous ovarian cancer with KRAS mutation and clear cell or endometrioid ovarian cancers with ARID1A mutations. With the current focus of molecular-targeted therapies for cancer, such druggable markers serve as excellent targets for precision therapy and combination therapy. This chapter, provides an overview of the critical molecular pathways activated in the ovarian cancer subtypes with its druggable targets studied in ovarian cancer. We also highlight the implications of miRNAs in chemoresistance and sensitivity in the regulation of ovarian cancer.",book:{id:"10342",slug:"ovarian-cancer-updates-in-tumour-biology-and-therapeutics",title:"Ovarian Cancer",fullTitle:"Ovarian Cancer - Updates in Tumour Biology and Therapeutics"},signatures:"Febina Ravindran and Bibha Choudhary",authors:[{id:"334121",title:"Prof.",name:"Bibha",middleName:null,surname:"Choudhary",slug:"bibha-choudhary",fullName:"Bibha Choudhary"},{id:"335007",title:"Dr.",name:"Febina",middleName:null,surname:"Ravindran",slug:"febina-ravindran",fullName:"Febina Ravindran"}]},{id:"42501",title:"Implication of Clear Cell and Mucinous Histology",slug:"implication-of-clear-cell-and-mucinous-histology",totalDownloads:2362,totalCrossrefCites:0,totalDimensionsCites:0,abstract:null,book:{id:"3449",slug:"ovarian-cancer-a-clinical-and-translational-update",title:"Ovarian Cancer",fullTitle:"Ovarian Cancer - A Clinical and Translational Update"},signatures:"Jun Naniwa, Hiroaki Itamochi and Junzo Kigawa",authors:[{id:"158925",title:"Prof.",name:"Junzo",middleName:null,surname:"Kigawa",slug:"junzo-kigawa",fullName:"Junzo Kigawa"}]},{id:"74781",title:"The Anti-Cancer Effects of Anti-Parasite Drug Ivermectin in Ovarian Cancer",slug:"the-anti-cancer-effects-of-anti-parasite-drug-ivermectin-in-ovarian-cancer",totalDownloads:900,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"Ivermectin is an old, common, and classic anti-parasite drug, which has been found to have a broad-spectrum anti-cancer effect on multiple human cancers. This chapter will focus on the anti-cancer effects of ivermectin on ovarian cancer. First, ivermectin was found to suppress cell proliferation and growth, block cell cycle progression, and promote cell apoptosis in ovarian cancer. Second, drug pathway network, qRT-PCR, and immunoaffinity blot analyses found that ivermectin acts through molecular networks to target the key molecules in energy metabolism pathways, including PFKP in glycolysis, IDH2 and IDH3B in Kreb’s cycle, ND2, ND5, CYTB, and UQCRH in oxidative phosphorylation, and MCT1 and MCT4 in lactate shuttle, to inhibit ovarian cancer growth. Third, the integrative analysis of TCGA transcriptomics and mitochondrial proteomics in ovarian cancer revealed that 16 survival-related lncRNAs were mediated by ivermectin, SILAC quantitative proteomics analysis revealed that ivermectin extensively inhibited the expressions of RNA-binding protein EIF4A3 and 116 EIF4A3-interacted genes including those key molecules in energy metabolism pathways, and also those lncRNAs regulated EIF4A3-mRNA axes. Thus, ivermectin mediated lncRNA-EIF4A3-mRNA axes in ovarian cancer to exert its anticancer capability. Further, lasso regression identified the prognostic model of ivermectin-related three-lncRNA signature (ZNRF3-AS1, SOS1-IT1, and LINC00565), which is significantly associated with overall survival and clinicopathologic characteristics in ovarian cancer patients. These ivermectin-related molecular pattern alterations benefit for prognostic assessment and personalized drug therapy toward 3P medicine practice in ovarian cancer.",book:{id:"10342",slug:"ovarian-cancer-updates-in-tumour-biology-and-therapeutics",title:"Ovarian Cancer",fullTitle:"Ovarian Cancer - Updates in Tumour Biology and Therapeutics"},signatures:"Xianquan Zhan and Na Li",authors:[{id:"223233",title:"Prof.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan"},{id:"438269",title:"Dr.",name:"Na",middleName:null,surname:"Li",slug:"na-li",fullName:"Na Li"}]},{id:"43345",title:"Surgical Treatment of Ovarian Cancer",slug:"surgical-treatment-of-ovarian-cancer",totalDownloads:2960,totalCrossrefCites:1,totalDimensionsCites:4,abstract:null,book:{id:"3449",slug:"ovarian-cancer-a-clinical-and-translational-update",title:"Ovarian Cancer",fullTitle:"Ovarian Cancer - A Clinical and Translational Update"},signatures:"Lucas Minig, M. 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He is a full professor of signal processing and pattern recognition and is head of the Signals and Communications Department at ULPGC, teaching from 2001 on subjects on signal processing and learning theory. His research lines are biometrics, biomedical signals and images, data mining, classification system, signal and image processing, machine learning, and environmental intelligence. He has researched in 52 international and Spanish research projects, some of them as head researcher. He is co-author of 4 books, co-editor of 27 proceedings books, guest editor for 8 JCR-ISI international journals, and up to 24 book chapters. He has over 450 papers published in international journals and conferences (81 of them indexed on JCR – ISI - Web of Science). He has published seven patents in the Spanish Patent and Trademark Office. He has been a supervisor on 8 Ph.D. theses (11 more are under supervision), and 130 master theses. He is the founder of The IEEE IWOBI conference series and the president of its Steering Committee, as well as the founder of both the InnoEducaTIC and APPIS conference series. He is an evaluator of project proposals for the European Union (H2020), Medical Research Council (MRC, UK), Spanish Government (ANECA, Spain), Research National Agency (ANR, France), DAAD (Germany), Argentinian Government, and the Colombian Institutions. He has been a reviewer in different indexed international journals (<70) and conferences (<250) since 2001. He has been a member of the IASTED Technical Committee on Image Processing from 2007 and a member of the IASTED Technical Committee on Artificial Intelligence and Expert Systems from 2011. \n\nHe has held the general chair position for the following: ACM-APPIS (2020, 2021), IEEE-IWOBI (2019, 2020 and 2020), A PPIS (2018, 2019), IEEE-IWOBI (2014, 2015, 2017, 2018), InnoEducaTIC (2014, 2017), IEEE-INES (2013), NoLISP (2011), JRBP (2012), and IEEE-ICCST (2005)\n\nHe is an associate editor of the Computational Intelligence and Neuroscience Journal (Hindawi – Q2 JCR-ISI). He was vice dean from 2004 to 2010 in the Higher Technical School of Telecommunication Engineers at ULPGC and the vice dean of Graduate and Postgraduate Studies from March 2013 to November 2017. He won the “Catedra Telefonica” Awards in Modality of Knowledge Transfer, 2017, 2018, and 2019 editions, and awards in Modality of COVID Research in 2020.\n\nPublic References:\nResearcher ID http://www.researcherid.com/rid/N-5967-2014\nORCID https://orcid.org/0000-0002-4621-2768 \nScopus Author ID https://www.scopus.com/authid/detail.uri?authorId=6602376272\nScholar Google https://scholar.google.es/citations?user=G1ks9nIAAAAJ&hl=en \nResearchGate https://www.researchgate.net/profile/Carlos_Travieso",institutionString:null,institution:{name:"University of Las Palmas de Gran Canaria",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"23",title:"Computational Neuroscience",coverUrl:"https://cdn.intechopen.com/series_topics/covers/23.jpg",isOpenForSubmission:!0,editor:{id:"14004",title:"Dr.",name:"Magnus",middleName:null,surname:"Johnsson",slug:"magnus-johnsson",fullName:"Magnus Johnsson",profilePictureURL:"https://mts.intechopen.com/storage/users/14004/images/system/14004.png",biography:"Dr Magnus Johnsson is a cross-disciplinary scientist, lecturer, scientific editor and AI/machine learning consultant from Sweden. \n\nHe is currently at Malmö University in Sweden, but also held positions at Lund University in Sweden and at Moscow Engineering Physics Institute. \nHe holds editorial positions at several international scientific journals and has served as a scientific editor for books and special journal issues. \nHis research interests are wide and include, but are not limited to, autonomous systems, computer modeling, artificial neural networks, artificial intelligence, cognitive neuroscience, cognitive robotics, cognitive architectures, cognitive aids and the philosophy of mind. \n\nDr. Johnsson has experience from working in the industry and he has a keen interest in the application of neural networks and artificial intelligence to fields like industry, finance, and medicine. \n\nWeb page: www.magnusjohnsson.se",institutionString:null,institution:{name:"Malmö University",institutionURL:null,country:{name:"Sweden"}}},editorTwo:null,editorThree:null},{id:"24",title:"Computer Vision",coverUrl:"https://cdn.intechopen.com/series_topics/covers/24.jpg",isOpenForSubmission:!0,editor:{id:"294154",title:"Prof.",name:"George",middleName:null,surname:"Papakostas",slug:"george-papakostas",fullName:"George Papakostas",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002hYaGbQAK/Profile_Picture_1624519712088",biography:"George A. Papakostas has received a diploma in Electrical and Computer Engineering in 1999 and the M.Sc. and Ph.D. degrees in Electrical and Computer Engineering in 2002 and 2007, respectively, from the Democritus University of Thrace (DUTH), Greece. Dr. Papakostas serves as a Tenured Full Professor at the Department of Computer Science, International Hellenic University, Greece. Dr. Papakostas has 10 years of experience in large-scale systems design as a senior software engineer and technical manager, and 20 years of research experience in the field of Artificial Intelligence. Currently, he is the Head of the “Visual Computing” division of HUman-MAchines INteraction Laboratory (HUMAIN-Lab) and the Director of the MPhil program “Advanced Technologies in Informatics and Computers” hosted by the Department of Computer Science, International Hellenic University. He has (co)authored more than 150 publications in indexed journals, international conferences and book chapters, 1 book (in Greek), 3 edited books, and 5 journal special issues. His publications have more than 2100 citations with h-index 27 (GoogleScholar). His research interests include computer/machine vision, machine learning, pattern recognition, computational intelligence. \nDr. Papakostas served as a reviewer in numerous journals, as a program\ncommittee member in international conferences and he is a member of the IAENG, MIR Labs, EUCogIII, INSTICC and the Technical Chamber of Greece (TEE).",institutionString:null,institution:{name:"International Hellenic University",institutionURL:null,country:{name:"Greece"}}},editorTwo:null,editorThree:null},{id:"25",title:"Evolutionary Computation",coverUrl:"https://cdn.intechopen.com/series_topics/covers/25.jpg",isOpenForSubmission:!0,editor:{id:"136112",title:"Dr.",name:"Sebastian",middleName:null,surname:"Ventura Soto",slug:"sebastian-ventura-soto",fullName:"Sebastian Ventura Soto",profilePictureURL:"https://mts.intechopen.com/storage/users/136112/images/system/136112.png",biography:"Sebastian Ventura is a Spanish researcher, a full professor with the Department of Computer Science and Numerical Analysis, University of Córdoba. Dr Ventura also holds the positions of Affiliated Professor at Virginia Commonwealth University (Richmond, USA) and Distinguished Adjunct Professor at King Abdulaziz University (Jeddah, Saudi Arabia). Additionally, he is deputy director of the Andalusian Research Institute in Data Science and Computational Intelligence (DaSCI) and heads the Knowledge Discovery and Intelligent Systems Research Laboratory. He has published more than ten books and over 300 articles in journals and scientific conferences. Currently, his work has received over 18,000 citations according to Google Scholar, including more than 2200 citations in 2020. In the last five years, he has published more than 60 papers in international journals indexed in the JCR (around 70% of them belonging to first quartile journals) and he has edited some Springer books “Supervised Descriptive Pattern Mining” (2018), “Multiple Instance Learning - Foundations and Algorithms” (2016), and “Pattern Mining with Evolutionary Algorithms” (2016). He has also been involved in more than 20 research projects supported by the Spanish and Andalusian governments and the European Union. He currently belongs to the editorial board of PeerJ Computer Science, Information Fusion and Engineering Applications of Artificial Intelligence journals, being also associate editor of Applied Computational Intelligence and Soft Computing and IEEE Transactions on Cybernetics. Finally, he is editor-in-chief of Progress in Artificial Intelligence. He is a Senior Member of the IEEE Computer, the IEEE Computational Intelligence, and the IEEE Systems, Man, and Cybernetics Societies, and the Association of Computing Machinery (ACM). Finally, his main research interests include data science, computational intelligence, and their applications.",institutionString:null,institution:{name:"University of Córdoba",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"26",title:"Machine Learning and Data Mining",coverUrl:"https://cdn.intechopen.com/series_topics/covers/26.jpg",isOpenForSubmission:!0,editor:{id:"24555",title:"Dr.",name:"Marco Antonio",middleName:null,surname:"Aceves Fernandez",slug:"marco-antonio-aceves-fernandez",fullName:"Marco Antonio Aceves Fernandez",profilePictureURL:"https://mts.intechopen.com/storage/users/24555/images/system/24555.jpg",biography:"Dr. Marco Antonio Aceves Fernandez obtained his B.Sc. (Eng.) in Telematics from the Universidad de Colima, Mexico. He obtained both his M.Sc. and Ph.D. from the University of Liverpool, England, in the field of Intelligent Systems. He is a full professor at the Universidad Autonoma de Queretaro, Mexico, and a member of the National System of Researchers (SNI) since 2009. Dr. Aceves Fernandez has published more than 80 research papers as well as a number of book chapters and congress papers. He has contributed in more than 20 funded research projects, both academic and industrial, in the area of artificial intelligence, ranging from environmental, biomedical, automotive, aviation, consumer, and robotics to other applications. He is also a honorary president at the National Association of Embedded Systems (AMESE), a senior member of the IEEE, and a board member of many institutions. 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He has both an MS and Ph.D. in Biomedical Engineering. He was previously a research scientist at the University of California Los Angeles (UCLA) and visiting professor and researcher at the University of North Dakota. He is currently working in artificial intelligence and its applications in medical signal processing. In addition, he is using digital signal processing in medical imaging and speech processing. Dr. Asadpour has developed brain-computer interfacing algorithms and has published books, book chapters, and several journal and conference papers in this field and other areas of intelligent signal processing. He has also designed medical devices, including a laser Doppler monitoring system.",institutionString:"Kaiser Permanente Southern California",institution:null},{id:"169608",title:"Prof.",name:"Marian",middleName:null,surname:"Găiceanu",slug:"marian-gaiceanu",fullName:"Marian Găiceanu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/169608/images/system/169608.png",biography:"Prof. Dr. Marian Gaiceanu graduated from the Naval and Electrical Engineering Faculty, Dunarea de Jos University of Galati, Romania, in 1997. He received a Ph.D. (Magna Cum Laude) in Electrical Engineering in 2002. Since 2017, Dr. Gaiceanu has been a Ph.D. supervisor for students in Electrical Engineering. He has been employed at Dunarea de Jos University of Galati since 1996, where he is currently a professor. Dr. Gaiceanu is a member of the National Council for Attesting Titles, Diplomas and Certificates, an expert of the Executive Agency for Higher Education, Research Funding, and a member of the Senate of the Dunarea de Jos University of Galati. He has been the head of the Integrated Energy Conversion Systems and Advanced Control of Complex Processes Research Center, Romania, since 2016. He has conducted several projects in power converter systems for electrical drives, power quality, PEM and SOFC fuel cell power converters for utilities, electric vehicles, and marine applications with the Department of Regulation and Control, SIEI S.pA. (2002–2004) and the Polytechnic University of Turin, Italy (2002–2004, 2006–2007). He is a member of the Institute of Electrical and Electronics Engineers (IEEE) and cofounder-member of the IEEE Power Electronics Romanian Chapter. He is a guest editor at Energies and an academic book editor for IntechOpen. He is also a member of the editorial boards of the Journal of Electrical Engineering, Electronics, Control and Computer Science and Sustainability. Dr. Gaiceanu has been General Chairman of the IEEE International Symposium on Electrical and Electronics Engineering in the last six editions.",institutionString:'"Dunarea de Jos" University of Galati',institution:{name:'"Dunarea de Jos" University of Galati',country:{name:"Romania"}}},{id:"4519",title:"Prof.",name:"Jaydip",middleName:null,surname:"Sen",slug:"jaydip-sen",fullName:"Jaydip Sen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/4519/images/system/4519.jpeg",biography:"Jaydip Sen is associated with Praxis Business School, Kolkata, India, as a professor in the Department of Data Science. His research areas include security and privacy issues in computing and communication, intrusion detection systems, machine learning, deep learning, and artificial intelligence in the financial domain. He has more than 200 publications in reputed international journals, refereed conference proceedings, and 20 book chapters in books published by internationally renowned publishing houses, such as Springer, CRC press, IGI Global, etc. Currently, he is serving on the editorial board of the prestigious journal Frontiers in Communications and Networks and in the technical program committees of a number of high-ranked international conferences organized by the IEEE, USA, and the ACM, USA. He has been listed among the top 2% of scientists in the world for the last three consecutive years, 2019 to 2021 as per studies conducted by the Stanford University, USA.",institutionString:"Praxis Business School",institution:null},{id:"320071",title:"Dr.",name:"Sidra",middleName:null,surname:"Mehtab",slug:"sidra-mehtab",fullName:"Sidra Mehtab",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00002v6KHoQAM/Profile_Picture_1584512086360",biography:"Sidra Mehtab has completed her BS with honors in Physics from Calcutta University, India in 2018. She has done MS in Data Science and Analytics from Maulana Abul Kalam Azad University of Technology (MAKAUT), Kolkata, India in 2020. Her research areas include Econometrics, Time Series Analysis, Machine Learning, Deep Learning, Artificial Intelligence, and Computer and Network Security with a particular focus on Cyber Security Analytics. Ms. Mehtab has published seven papers in international conferences and one of her papers has been accepted for publication in a reputable international journal. She has won the best paper awards in two prestigious international conferences – BAICONF 2019, and ICADCML 2021, organized in the Indian Institute of Management, Bangalore, India in December 2019, and SOA University, Bhubaneswar, India in January 2021. Besides, Ms. Mehtab has also published two book chapters in two books. Seven of her book chapters will be published in a volume shortly in 2021 by Cambridge Scholars’ Press, UK. Currently, she is working as the joint editor of two edited volumes on Time Series Analysis and Forecasting to be published in the first half of 2021 by an international house. Currently, she is working as a Data Scientist with an MNC in Delhi, India.",institutionString:"NSHM College of Management and Technology",institution:null},{id:"226240",title:"Dr.",name:"Andri Irfan",middleName:null,surname:"Rifai",slug:"andri-irfan-rifai",fullName:"Andri Irfan Rifai",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/226240/images/7412_n.jpg",biography:"Andri IRFAN is a Senior Lecturer of Civil Engineering and Planning. He completed the PhD at the Universitas Indonesia & Universidade do Minho with Sandwich Program Scholarship from the Directorate General of Higher Education and LPDP scholarship. He has been teaching for more than 19 years and much active to applied his knowledge in the project construction in Indonesia. His research interest ranges from pavement management system to advanced data mining techniques for transportation engineering. He has published more than 50 papers in journals and 2 books.",institutionString:null,institution:{name:"Universitas Internasional Batam",country:{name:"Indonesia"}}},{id:"314576",title:"Dr.",name:"Ibai",middleName:null,surname:"Laña",slug:"ibai-lana",fullName:"Ibai Laña",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/314576/images/system/314576.jpg",biography:"Dr. Ibai Laña works at TECNALIA as a data analyst. He received his Ph.D. in Artificial Intelligence from the University of the Basque Country (UPV/EHU), Spain, in 2018. He is currently a senior researcher at TECNALIA. His research interests fall within the intersection of intelligent transportation systems, machine learning, traffic data analysis, and data science. He has dealt with urban traffic forecasting problems, applying machine learning models and evolutionary algorithms. He has experience in origin-destination matrix estimation or point of interest and trajectory detection. Working with large volumes of data has given him a good command of big data processing tools and NoSQL databases. He has also been a visiting scholar at the Knowledge Engineering and Discovery Research Institute, Auckland University of Technology.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"314575",title:"Dr.",name:"Jesus",middleName:null,surname:"L. Lobo",slug:"jesus-l.-lobo",fullName:"Jesus L. Lobo",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/314575/images/system/314575.png",biography:"Dr. Jesús López is currently based in Bilbao (Spain) working at TECNALIA as Artificial Intelligence Research Scientist. In most cases, a project idea or a new research line needs to be investigated to see if it is good enough to take into production or to focus on it. That is exactly what he does, diving into Machine Learning algorithms and technologies to help TECNALIA to decide whether something is great in theory or will actually impact on the product or processes of its projects. So, he is expert at framing experiments, developing hypotheses, and proving whether they’re true or not, in order to investigate fundamental problems with a longer time horizon. He is also able to design and develop PoCs and system prototypes in simulation. He has participated in several national and internacional R&D projects.\n\nAs another relevant part of his everyday research work, he usually publishes his findings in reputed scientific refereed journals and international conferences, occasionally acting as reviewer and Programme Commitee member. Concretely, since 2018 he has published 9 JCR (8 Q1) journal papers, 9 conference papers (e.g. ECML PKDD 2021), and he has co-edited a book. He is also active in popular science writing data science stories for reputed blogs (KDNuggets, TowardsDataScience, Naukas). Besides, he has recently embarked on mentoring programmes as mentor, and has also worked as data science trainer.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"103779",title:"Prof.",name:"Yalcin",middleName:null,surname:"Isler",slug:"yalcin-isler",fullName:"Yalcin Isler",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRyQ8QAK/Profile_Picture_1628834958734",biography:"Yalcin Isler (1971 - Burdur / Turkey) received the B.Sc. degree in the Department of Electrical and Electronics Engineering from Anadolu University, Eskisehir, Turkey, in 1993, the M.Sc. degree from the Department of Electronics and Communication Engineering, Suleyman Demirel University, Isparta, Turkey, in 1996, the Ph.D. degree from the Department of Electrical and Electronics Engineering, Dokuz Eylul University, Izmir, Turkey, in 2009, and the Competence of Associate Professorship from the Turkish Interuniversity Council in 2019.\n\nHe was Lecturer at Burdur Vocational School in Suleyman Demirel University (1993-2000, Burdur / Turkey), Software Engineer (2000-2002, Izmir / Turkey), Research Assistant in Bulent Ecevit University (2002-2003, Zonguldak / Turkey), Research Assistant in Dokuz Eylul University (2003-2010, Izmir / Turkey), Assistant Professor at the Department of Electrical and Electronics Engineering in Bulent Ecevit University (2010-2012, Zonguldak / Turkey), Assistant Professor at the Department of Biomedical Engineering in Izmir Katip Celebi University (2012-2019, Izmir / Turkey). He is an Associate Professor at the Department of Biomedical Engineering at Izmir Katip Celebi University, Izmir / Turkey, since 2019. In addition to academics, he has also founded Islerya Medical and Information Technologies Company, Izmir / Turkey, since 2017.\n\nHis main research interests cover biomedical signal processing, pattern recognition, medical device design, programming, and embedded systems. He has many scientific papers and participated in several projects in these study fields. He was an IEEE Student Member (2009-2011) and IEEE Member (2011-2014) and has been IEEE Senior Member since 2014.",institutionString:null,institution:{name:"Izmir Kâtip Çelebi University",country:{name:"Turkey"}}},{id:"339677",title:"Dr.",name:"Mrinmoy",middleName:null,surname:"Roy",slug:"mrinmoy-roy",fullName:"Mrinmoy Roy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/339677/images/16768_n.jpg",biography:"An accomplished Sales & Marketing professional with 12 years of cross-functional experience in well-known organisations such as CIPLA, LUPIN, GLENMARK, ASTRAZENECA across different segment of Sales & Marketing, International Business, Institutional Business, Product Management, Strategic Marketing of HIV, Oncology, Derma, Respiratory, Anti-Diabetic, Nutraceutical & Stomatological Product Portfolio and Generic as well as Chronic Critical Care Portfolio. A First Class MBA in International Business & Strategic Marketing, B.Pharm, D.Pharm, Google Certified Digital Marketing Professional. Qualified PhD Candidate in Operations and Management with special focus on Artificial Intelligence and Machine Learning adoption, analysis and use in Healthcare, Hospital & Pharma Domain. Seasoned with diverse therapy area of Pharmaceutical Sales & Marketing ranging from generating revenue through generating prescriptions, launching new products, and making them big brands with continuous strategy execution at the Physician and Patients level. Moved from Sales to Marketing and Business Development for 3.5 years in South East Asian Market operating from Manila, Philippines. Came back to India and handled and developed Brands such as Gluconorm, Lupisulin, Supracal, Absolut Woman, Hemozink, Fabiflu (For COVID 19), and many more. In my previous assignment I used to develop and execute strategies on Sales & Marketing, Commercialization & Business Development for Institution and Corporate Hospital Business portfolio of Oncology Therapy Area for AstraZeneca Pharma India Ltd. Being a Research Scholar and Student of ‘Operations Research & Management: Artificial Intelligence’ I published several pioneer research papers and book chapters on the same in Internationally reputed journals and Books indexed in Scopus, Springer and Ei Compendex, Google Scholar etc. Currently, I am launching PGDM Pharmaceutical Management Program in IIHMR Bangalore and spearheading the course curriculum and structure of the same. I am interested in Collaboration for Healthcare Innovation, Pharma AI Innovation, Future trend in Marketing and Management with incubation on Healthcare, Healthcare IT startups, AI-ML Modelling and Healthcare Algorithm based training module development. I am also an affiliated member of the Institute of Management Consultant of India, looking forward to Healthcare, Healthcare IT and Innovation, Pharma and Hospital Management Consulting works.",institutionString:null,institution:{name:"Lovely Professional University",country:{name:"India"}}},{id:"310576",title:"Prof.",name:"Erick Giovani",middleName:null,surname:"Sperandio Nascimento",slug:"erick-giovani-sperandio-nascimento",fullName:"Erick Giovani Sperandio Nascimento",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0033Y00002pDKxDQAW/ProfilePicture%202022-06-20%2019%3A57%3A24.788",biography:"Prof. Erick Sperandio is the Lead Researcher and professor of Artificial Intelligence (AI) at SENAI CIMATEC, Bahia, Brazil, also working with Computational Modeling (CM) and HPC. He holds a PhD in Environmental Engineering in the area of Atmospheric Computational Modeling, a Master in Informatics in the field of Computational Intelligence and Graduated in Computer Science from UFES. He currently coordinates, leads and participates in R&D projects in the areas of AI, computational modeling and supercomputing applied to different areas such as Oil and Gas, Health, Advanced Manufacturing, Renewable Energies and Atmospheric Sciences, advising undergraduate, master's and doctoral students. He is the Lead Researcher at SENAI CIMATEC's Reference Center on Artificial Intelligence. In addition, he is a Certified Instructor and University Ambassador of the NVIDIA Deep Learning Institute (DLI) in the areas of Deep Learning, Computer Vision, Natural Language Processing and Recommender Systems, and Principal Investigator of the NVIDIA/CIMATEC AI Joint Lab, the first in Latin America within the NVIDIA AI Technology Center (NVAITC) worldwide program. He also works as a researcher at the Supercomputing Center for Industrial Innovation (CS2i) and at the SENAI Institute of Innovation for Automation (ISI Automação), both from SENAI CIMATEC. He is a member and vice-coordinator of the Basic Board of Scientific-Technological Advice and Evaluation, in the area of Innovation, of the Foundation for Research Support of the State of Bahia (FAPESB). He serves as Technology Transfer Coordinator and one of the Principal Investigators at the National Applied Research Center in Artificial Intelligence (CPA-IA) of SENAI CIMATEC, focusing on Industry, being one of the six CPA-IA in Brazil approved by MCTI / FAPESP / CGI.br. He also participates as one of the representatives of Brazil in the BRICS Innovation Collaboration Working Group on HPC, ICT and AI. He is the coordinator of the Work Group of the Axis 5 - Workforce and Training - of the Brazilian Strategy for Artificial Intelligence (EBIA), and member of the MCTI/EMBRAPII AI Innovation Network Training Committee. He is the coordinator, by SENAI CIMATEC, of the Artificial Intelligence Reference Network of the State of Bahia (REDE BAH.IA). He leads the working group of experts representing Brazil in the Global Partnership on Artificial Intelligence (GPAI), on the theme \"AI and the Pandemic Response\".",institutionString:"Manufacturing and Technology Integrated Campus – SENAI CIMATEC",institution:null},{id:"1063",title:"Prof.",name:"Constantin",middleName:null,surname:"Volosencu",slug:"constantin-volosencu",fullName:"Constantin Volosencu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/1063/images/system/1063.png",biography:"Prof. Dr. Constantin Voloşencu graduated as an engineer from\nPolitehnica University of Timișoara, Romania, where he also\nobtained a doctorate degree. He is currently a full professor in\nthe Department of Automation and Applied Informatics at the\nsame university. Dr. Voloşencu is the author of ten books, seven\nbook chapters, and more than 160 papers published in journals\nand conference proceedings. He has also edited twelve books and\nhas twenty-seven patents to his name. He is a manager of research grants, editor in\nchief and member of international journal editorial boards, a former plenary speaker, a member of scientific committees, and chair at international conferences. His\nresearch is in the fields of control systems, control of electric drives, fuzzy control\nsystems, neural network applications, fault detection and diagnosis, sensor network\napplications, monitoring of distributed parameter systems, and power ultrasound\napplications. He has developed automation equipment for machine tools, spooling\nmachines, high-power ultrasound processes, and more.",institutionString:"Polytechnic University of Timişoara",institution:{name:"Polytechnic University of Timişoara",country:{name:"Romania"}}},{id:"221364",title:"Dr.",name:"Eneko",middleName:null,surname:"Osaba",slug:"eneko-osaba",fullName:"Eneko Osaba",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/221364/images/system/221364.jpg",biography:"Dr. Eneko Osaba works at TECNALIA as a senior researcher. He obtained his Ph.D. in Artificial Intelligence in 2015. He has participated in more than twenty-five local and European research projects, and in the publication of more than 130 papers. He has performed several stays at universities in the United Kingdom, Italy, and Malta. Dr. Osaba has served as a program committee member in more than forty international conferences and participated in organizing activities in more than ten international conferences. He is a member of the editorial board of the International Journal of Artificial Intelligence, Data in Brief, and Journal of Advanced Transportation. He is also a guest editor for the Journal of Computational Science, Neurocomputing, Swarm, and Evolutionary Computation and IEEE ITS Magazine.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"275829",title:"Dr.",name:"Esther",middleName:null,surname:"Villar-Rodriguez",slug:"esther-villar-rodriguez",fullName:"Esther Villar-Rodriguez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/275829/images/system/275829.jpg",biography:"Dr. Esther Villar obtained a Ph.D. in Information and Communication Technologies from the University of Alcalá, Spain, in 2015. She obtained a degree in Computer Science from the University of Deusto, Spain, in 2010, and an MSc in Computer Languages and Systems from the National University of Distance Education, Spain, in 2012. Her areas of interest and knowledge include natural language processing (NLP), detection of impersonation in social networks, semantic web, and machine learning. Dr. Esther Villar made several contributions at conferences and publishing in various journals in those fields. Currently, she is working within the OPTIMA (Optimization Modeling & Analytics) business of TECNALIA’s ICT Division as a data scientist in projects related to the prediction and optimization of management and industrial processes (resource planning, energy efficiency, etc).",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"49813",title:"Dr.",name:"Javier",middleName:null,surname:"Del Ser",slug:"javier-del-ser",fullName:"Javier Del Ser",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49813/images/system/49813.png",biography:"Prof. Dr. Javier Del Ser received his first PhD in Telecommunication Engineering (Cum Laude) from the University of Navarra, Spain, in 2006, and a second PhD in Computational Intelligence (Summa Cum Laude) from the University of Alcala, Spain, in 2013. He is currently a principal researcher in data analytics and optimisation at TECNALIA (Spain), a visiting fellow at the Basque Center for Applied Mathematics (BCAM) and a part-time lecturer at the University of the Basque Country (UPV/EHU). His research interests gravitate on the use of descriptive, prescriptive and predictive algorithms for data mining and optimization in a diverse range of application fields such as Energy, Transport, Telecommunications, Health and Industry, among others. In these fields he has published more than 240 articles, co-supervised 8 Ph.D. theses, edited 6 books, coauthored 7 patents and participated/led more than 40 research projects. 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He is also a progammer with programming experience in:\n\nA) Quantum Computing using Qiskit Python module and IBM Quantum Experience Platform, with software developed on the simulation of Quantum Artificial Neural Networks and Quantum Cybersecurity;\n\nB) Artificial Intelligence and Machine learning programming in Python;\n\nC) Artificial Intelligence, Multiagent Systems Modeling and System Dynamics Modeling in Netlogo, with models developed in the areas of Chaos Theory, Econophysics, Artificial Intelligence, Classical and Quantum Complex Systems Science, with the Econophysics models having been cited worldwide and incorporated in PhD programs by different Universities.\n\nReceived an Arctic Code Vault Contributor status by GitHub, due to having developed open source software preserved in the \\"Arctic Code Vault\\" for future generations (https://archiveprogram.github.com/arctic-vault/), with the Strategy Analyzer A.I. module for decision making support (based on his PhD thesis, used in his Classes on Decision Making and in Strategic Intelligence Consulting Activities) and QNeural Python Quantum Neural Network simulator also preserved in the \\"Arctic Code Vault\\", for access to these software modules see: https://github.com/cpgoncalves. He is also a peer reviewer with outsanding review status from Elsevier journals, including Physica A, Neurocomputing and Engineering Applications of Artificial Intelligence. 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Currently working as an Assistant Professor in the Department of Mathematics, Institute of Applied Science, Mangalayatan University, Aligarh. She taught so many courses of Mathematics of UG and PG level. Her research Area of Expertise is Functional Analysis & Sequence Spaces. She has been working on Ideal Convergence of double sequence. She has published 17 research papers in National and International Journals including Cogent Mathematics, Filomat, Journal of Intelligent and Fuzzy Systems, Advances in Difference Equations, Journal of Mathematical Analysis, Journal of Mathematical & Computer Science etc. She has also reviewed few research papers for the and international journals. 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He obtained his Master’s degree in the Department of Information and Communications from Gwangju Institute of Science and Technology (GIST) in 2003. In 2010, he received his Ph.D. degree in the School of Information and Mechatronics from GIST. In the meantime, he was an executed team leader at Culture Technology Institute, GIST, 2010-2012. In 2011, he worked at Lancaster University, the UK as a visiting scholar. In September 2012, he joined Daegu University, where he is currently an associate professor in the School of ICT Conver, Daegu University. Also, he served as the Board of Directors of KSIIS since 2019, and HCI Korea since 2016. From 2017~2019, he worked as a center director of the Mixed Reality Convergence Research Center at Daegu University. From 2015-2017, He worked as a director in the Enterprise Supporting Office of LINC Project Group, Daegu University. 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Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. 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