\\n\\n
Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\\n\\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\\n"}]',published:!0,mainMedia:{caption:"Highly Cited",originalUrl:"/media/original/117"}},components:[{type:"htmlEditorComponent",content:'IntechOpen is proud to announce that 191 of our authors have made the Clarivate™ Highly Cited Researchers List for 2020, ranking them among the top 1% most-cited.
\n\nThroughout the years, the list has named a total of 261 IntechOpen authors as Highly Cited. Of those researchers, 69 have been featured on the list multiple times.
\n\n\n\nReleased this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\n\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"10326",leadTitle:null,fullTitle:"Advances in Hepatology",title:"Advances in Hepatology",subtitle:null,reviewType:"peer-reviewed",abstract:"This book discusses clinical advances in hepatology, with a focus on metabolic diseases and chronic hepatitis C. The development of direct-acting antiviral (DAA) agents for the treatment of hepatitis C virus (HCV) infection in 2010 has completely transformed the management of this disease. This transformative nature of DAA therapy underpins the goal of the World Health Organization (WHO) to eliminate HCV infection as a public health threat by 2030. The advantages of using these therapies include high efficacy (sustained virological response rate >95%) with minimal side effects, good tolerability, easy drug administration (once-daily oral dosing) and short duration of treatment (8-12 weeks). The commercialization of second-generation DAA agents due to their high effectiveness, few side-effects and pangenotypic action. This transformative nature of DAA therapy underpins the goal of the WHO to eliminate HCV infection as a public health threat by 2030.",isbn:"978-1-83968-624-5",printIsbn:"978-1-83968-623-8",pdfIsbn:"978-1-83968-625-2",doi:"10.5772/intechopen.91512",price:119,priceEur:129,priceUsd:155,slug:"advances-in-hepatology",numberOfPages:258,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"356bcd9352c844e5524bb8e79cf6e7fe",bookSignature:"Luis Rodrigo, Ian Martins, Xiaozhong Guo and Xingshun Qi",publishedDate:"July 28th 2021",coverURL:"https://cdn.intechopen.com/books/images_new/10326.jpg",numberOfDownloads:3601,numberOfWosCitations:0,numberOfCrossrefCitations:0,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:0,numberOfDimensionsCitationsByBook:0,hasAltmetrics:1,numberOfTotalCitations:0,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"August 31st 2020",dateEndSecondStepPublish:"September 28th 2020",dateEndThirdStepPublish:"November 27th 2020",dateEndFourthStepPublish:"February 15th 2021",dateEndFifthStepPublish:"April 16th 2021",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"73208",title:"Prof.",name:"Luis",middleName:null,surname:"Rodrigo",slug:"luis-rodrigo",fullName:"Luis Rodrigo",profilePictureURL:"https://mts.intechopen.com/storage/users/73208/images/system/73208.jpg",biography:"Dr. Luis Rodrigo, MD, is a Professor Emeritus of Medicine, at the University of Oviedo, Spain. He has been Chief of Gastroenterology Service at HUCA Hospital, Oviedo, for more than forty years. He obtained a Ph.D. in 1975 and has developed a long teaching and research career. Dr. Rodrigo has published 716 scientific papers, 435 written in English and the rest in Spanish. He has participated as the main investigator in forty-five clinical trials and has directed forty doctoral theses. He has contributed actively to the formation of around 100 specialists in gastroenterology working in his hospital and other hospitals in Spain and abroad. He has written around thirty-five book chapters and edited twenty-six books in his specialty and related diseases.",institutionString:"University of Oviedo",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"5",totalChapterViews:"0",totalEditedBooks:"17",institution:{name:"University of Oviedo",institutionURL:null,country:{name:"Spain"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:{id:"179745",title:"Dr.",name:"Ian James",middleName:null,surname:"Martins",slug:"ian-james-martins",fullName:"Ian James Martins",profilePictureURL:"https://mts.intechopen.com/storage/users/179745/images/system/179745.jpg",biography:"Dr. Ian James Martins has a DSc in Science in Nutrition and an MD in Diabetology. He is an editor and reviewer for various national and international journals. He received the Distinguished Scientist award from the International Scientist Awards on Engineering, Science and Medicine in 2021. He was also recognized as Top Peer Reviewer by the Global Peer Review Awards in 2019. Dr. Martins ranks in the top 1% of cited researchers according to the Essential Science Indicators (ESI) tool. He has an h index of 132 with more than 15,000 citations over the past 27 years. He also has 205 international certificates from journals, conferences, congresses, and summits. Dr. Martins is a member of the BIT Congress.",institutionString:"Independent Scientist",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"3",totalChapterViews:"0",totalEditedBooks:"1",institution:null},coeditorTwo:{id:"321045",title:"Prof.",name:"Xiaozhong",middleName:null,surname:"Guo",slug:"xiaozhong-guo",fullName:"Xiaozhong Guo",profilePictureURL:"https://mts.intechopen.com/storage/users/321045/images/system/321045.jpg",biography:"Prof. Xiaozhong Guo is the director of the Department of Gastroenterology, General Hospital of Northern Theater Command, China(formerly General Hospital of Shenyang Military Area). He has practiced in the field of digestive diseases and digestive endoscopy for more than thirty years. His major achievements include experimental and clinical research on the management of pancreatic diseases, especially pancreatic cancer, and stem cells for digestive diseases such as liver cirrhosis and ulcerative colitis. He has published more than 500 papers and edited more than ten books. He has received six funds from the National Natural Science Foundation of China. He received first prizes from the Natural Science and Science and Technology Progress Awards of Liaoning Province.",institutionString:"General Hospital of Northern Theater Command",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"0",institution:null},coeditorThree:{id:"197501",title:"Dr.",name:"Xingshun",middleName:null,surname:"Qi",slug:"xingshun-qi",fullName:"Xingshun Qi",profilePictureURL:"https://mts.intechopen.com/storage/users/197501/images/system/197501.png",biography:"Dr. Xingshun Qi is a deputy director at the Department of Gastroenterology, General Hospital of Northern Theater Command, China (formerly General Hospital of Shenyang Military Area). His major research interests are the management of liver cirrhosis, portal hypertension (especially portal vein thrombosis and Budd-Chiari syndrome), and hepatocellular carcinoma. He has edited eight English-language books and serves as an associate editor for BMC Gastroenterology, an associate editor for Frontiers in Medicine, an academic editor for Canadian Journal of Gastroenterology and Hepatology, an editorial board member of Therapeutic Advances in Gastroenterology, and an advisory editorial member of Advances in Therapy.",institutionString:"General Hospital of Northern Theater Command",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"6",totalChapterViews:"0",totalEditedBooks:"4",institution:null},coeditorFour:null,coeditorFive:null,topics:[{id:"1021",title:"Hepatology",slug:"gastroenterology-hepatology"}],chapters:[{id:"77001",title:"Discovery of Hepatitis C Virus: Nobel Prize in Physiology and Medicine 2020",doi:"10.5772/intechopen.96734",slug:"discovery-of-hepatitis-c-virus-nobel-prize-in-physiology-and-medicine-2020",totalDownloads:212,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Scientists were successful in discovering Hepatitis A and B, but there is another virus which has a long incubation period, many people are asymptomatic and cause adverse effects. Three scientists Harvey J Alter, Michael Houghton and Charles M Rice who have contributed their work in discovering a non-A, non-B hepatitis virus called Hepatitis C. Hepatitis is a disorder associated with the functioning hepatic cells in the liver. The person infected with Hepatitis C will have poor functioning of liver, vomiting, fatigue, jaundice and appetite. In this paper, I am going to explain about the Hepatitis C virus, and the work was done by three scientists and various research around it.",signatures:"Talari Praveen",downloadPdfUrl:"/chapter/pdf-download/77001",previewPdfUrl:"/chapter/pdf-preview/77001",authors:[{id:"340991",title:"Mr.",name:"Talari",surname:"Praveen",slug:"talari-praveen",fullName:"Talari Praveen"}],corrections:null},{id:"76077",title:"Hepatitis C: An Overview",doi:"10.5772/intechopen.94879",slug:"hepatitis-c-an-overview",totalDownloads:223,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Hepatitis C virus (HCV) has infected approximatelly 130–170 milion individuals in the form of chronic liver infection and hepatocellular carcinoma. In the majority of patients with the increased risk for hepatocellular carcinoma the initial rearrangement is fibrosis. HCV is a bloodborne virus. The most common route of the infection are drug use, injections, unsafe health care performance, transfusion and sexual transmission. The incubation period ranges from 2 to 6 weeks in case of HCV. HCV infection is diagnosed in the process of detecting of anti-HCV antibodies and if positive, a nucleic acid test for HCV ribonucleic acid (RNA) is done. Currently, the most promising treatment agents are direct-acting antivirals (DAAs). They have shown limited viral resistance, long treatment duration and higher cost with no proven benefits in the prevention of graft reinfections in HCV individuals. In the light of the aforementioned, there is a need to a more dubious research in the quest for the effective therapeutic modalities.",signatures:"Syed Manzoor Kadri and Marija Petkovic",downloadPdfUrl:"/chapter/pdf-download/76077",previewPdfUrl:"/chapter/pdf-preview/76077",authors:[{id:"289637",title:"Dr.",name:"Syed Manzoor",surname:"Kadri",slug:"syed-manzoor-kadri",fullName:"Syed Manzoor Kadri"},{id:"303147",title:"Dr.",name:"Marija",surname:"Petković",slug:"marija-petkovic",fullName:"Marija Petković"}],corrections:null},{id:"75091",title:"Extrahepatic Manifestations of Hepatitis C Infection",doi:"10.5772/intechopen.95995",slug:"extrahepatic-manifestations-of-hepatitis-c-infection",totalDownloads:266,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:1,abstract:"Chronic infection with the hepatitis C virus (HCV) is a major cause of liver disease worldwide and is also responsible for extrahepatic manifestations (EHM) involving many different organs and apparatus: skin, salivary glands, eyes, thyroid, kidneys, peripheral and central nervous system, and immune system. Mixed cryoglobulinemia is the most frequent, best known and strictly HCV-associated EHM. A significant association between HCV and B-cell Non-Hodgkin-Lymphoma is reported although the incidence of lymphoma among HCV-infected patients overall remains low. HCV-infected patients have increased rates of insulin resistance, diabetes, and atherosclerosis, which may lead to increased cardiovascular disorders. The mechanisms causing the extrahepatic effects of HCV infection are likely multifactorial and may include endocrine effects, HCV replication in extrahepatic cells, or a heightened immune reaction with systemic effects. Because of this associations, it is suggested testing for HCV infection the patients with a clinical condition described as linked to hepatitis C. Conversely, patients diagnosed with HCV infection should have evaluation for a possible EHM. EHM of HCV can be considered an established indication for antiviral treatment with direct acting antivirals, even in the absence of overt liver disease. Successful eradication of HCV can improve and in some cases cure EHM of HCV. B cell depleting agents may be considered to be the best biological target option for patients with more severe EHM in combination with the antivirals.",signatures:"Alberto Frosi",downloadPdfUrl:"/chapter/pdf-download/75091",previewPdfUrl:"/chapter/pdf-preview/75091",authors:[{id:"333201",title:"Dr.",name:"Alberto",surname:"Frosi",slug:"alberto-frosi",fullName:"Alberto Frosi"}],corrections:null},{id:"74775",title:"Host-Targeting Antivirals for Treatment of Hepatitis C",doi:"10.5772/intechopen.95373",slug:"host-targeting-antivirals-for-treatment-of-hepatitis-c",totalDownloads:258,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Treatment of chronic hepatitis C virus (HCV) infection has been revolutionized during last years with the development of highly potent direct-acting antivirals (DAAs) specifically targeting HCV proteins. DAAs are the current standard of care for patients with chronic hepatitis C, leading to high cure rates. However, some hurdles exist including the high cost of these therapies restricting access to patients, their inability to protect against the risk of developing hepatocellular carcinoma in patients with advanced fibrosis, and emergence of resistant variants resulting in treatment failure. New therapeutic options should be essential to overcome DAAs limitations and improve survival. By targeting host-cell factors involved in HCV life cycle, host-targeting antivirals (HTAs) offer opportunity for promising anti-HCV therapy with low mutational rate and may act in a synergistic manner with DAAs to prevent viral resistance and reduce viral replication. Moreover, HTAs could be effective in difficult-to-cure patients by acting through complementary mechanisms. In this chapter, we will focus on the latest and most relevant studies regarding the host-cell factors required in HCV infection and explored as targets of antiviral therapy, we will also discuss the HTAs evaluated in preclinical and clinical development and their potential role as alternative or complementary therapeutic strategies.",signatures:"Bouchra Kitab, Michinori Kohara and Kyoko Tsukiyama-Kohara",downloadPdfUrl:"/chapter/pdf-download/74775",previewPdfUrl:"/chapter/pdf-preview/74775",authors:[{id:"332192",title:"Ph.D.",name:"Bouchra",surname:"Kitab",slug:"bouchra-kitab",fullName:"Bouchra Kitab"},{id:"332977",title:"Prof.",name:"Michinori",surname:"Kohara",slug:"michinori-kohara",fullName:"Michinori Kohara"},{id:"333160",title:"Prof.",name:"Kyoko",surname:"Tsukiyama-Kohara",slug:"kyoko-tsukiyama-kohara",fullName:"Kyoko Tsukiyama-Kohara"}],corrections:null},{id:"75494",title:"The Influence of Protease Inhibitors on the Evolution of Hepatitis C in Patients with HIV and HCV Co-Infection",doi:"10.5772/intechopen.96282",slug:"the-influence-of-protease-inhibitors-on-the-evolution-of-hepatitis-c-in-patients-with-hiv-and-hcv-co",totalDownloads:180,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Prevalence of hepatitis C in HIV infected patients is much higher than in the general population. There is the possibility of viral clearance HCV, in some patients co-infected HIV and HCV, in the phase of immune reconstruction after antiretroviral treatment (ART). There are patients’ anti-HCV positive who initially did not show HCV viral load detected and after the start of ART becomes HCV viral load detectable. There are studies that described that immune restoration with increase in CD4+ and CD8+ T cells, from ART, was important in control of HCV viremia. Has been proposed hypothesis that direct or indirect effect of ART on HCV replication play a role in spontaneous resolution of HCV infection. We evaluated the co-infected patients with HIV and HCV under combined antiretroviral treatment, containing PI boosted with ritonavir in terms of immunological and virological status (for both infection) and also liver disease. Patients were evaluated for liver damage by non-invasive methods. We have shown that a small percentage of patients have severe liver damage. We demonstrated the negative role of HCV on immunological status and in liver fibrosis in co-infected patients. A high proportion of these HIV and HCV co-infected patients had no detectable viremia, higher than other studies published.",signatures:"Elena Dumea and Simona Claudia Cambrea",downloadPdfUrl:"/chapter/pdf-download/75494",previewPdfUrl:"/chapter/pdf-preview/75494",authors:[{id:"189887",title:"Associate Prof.",name:"Simona Claudia",surname:"Cambrea",slug:"simona-claudia-cambrea",fullName:"Simona Claudia Cambrea"},{id:"189892",title:"Dr.",name:"Elena",surname:"Dumea",slug:"elena-dumea",fullName:"Elena Dumea"}],corrections:null},{id:"74932",title:"Liver Transplantation and HCV Genotype 4",doi:"10.5772/intechopen.95831",slug:"liver-transplantation-and-hcv-genotype-4",totalDownloads:277,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:1,abstract:"End-stage liver disease secondary to hepatitis C virus (HCV) infection is a major indication for liver transplantation (LT) worldwide. Previous studies have shown a negative impact of HCV on patient and graft survival leading to an inferior transplant outcome when compared to other liver transplant indications. The percentage of HCV patients infected with genotype 4 (G4) among recipients of OLT varies depending on geographic location. In the Middle East HCV-G4 infection is the most common genotype among transplant recipients. Direct antiviral agents (DAAs) have revolutionized the management of HCV infection in the pre- and post-transplant setting. Recent clinical trials have shown high sustained virologic response rates, shorter durations of treatment, and decreased adverse events when compared with the previous treatment of pegylated interferon (PEG-IFN)-based therapy. However, most of these studies were performed in HCV-G1-infected patients. Due to the low prevalence of HCV-G4 in Europe and the USA, this genotype has not been adequately studied in prospective trials evaluating treatment outcomes. The aim of this chapter is to summarize the natural history and treatment outcome of HCV-G4 in the liver transplant setting, with particular attention to new HCV therapies.",signatures:"Saad Alghamdi and Waleed Al-hamoudi",downloadPdfUrl:"/chapter/pdf-download/74932",previewPdfUrl:"/chapter/pdf-preview/74932",authors:[{id:"189855",title:"Prof.",name:"Waleed",surname:"Al-Hamoudi",slug:"waleed-al-hamoudi",fullName:"Waleed Al-Hamoudi"},{id:"332656",title:"Dr.",name:"Saad",surname:"Alghamdi",slug:"saad-alghamdi",fullName:"Saad Alghamdi"}],corrections:null},{id:"75455",title:"Hepatocellular Carcinoma and Antiviral Therapies in HCV Chronic Infection",doi:"10.5772/intechopen.96551",slug:"hepatocellular-carcinoma-and-antiviral-therapies-in-hcv-chronic-infection",totalDownloads:126,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The development of direct-acting antiviral (DAA) therapies in chronic HCV infection has been associated with increased expectations regarding the prognosis of this infection in the medical community, as the possibility of HCV eradication is now in sight. While the cure of the HVC infection has been associated with a dramatic decrease in its systemic complications, the impact on the progression of the liver disease, especially in patients with cirrhosis, is still controversial. Furthermore, the risk of developing hepatocellular carcinoma (HCC) after direct-acting antiviral therapy is debatable, with studies presenting an increased prevalence of HCC early after the introduction of these therapies, as well as newer contradicting studies. This chapter aims to examine the current literature data available regarding the impact of new HCV therapies in the incidence and prognosis of hepatocellular carcinoma.",signatures:"Laura Iliescu",downloadPdfUrl:"/chapter/pdf-download/75455",previewPdfUrl:"/chapter/pdf-preview/75455",authors:[{id:"312218",title:"Dr.",name:"Laura",surname:"Iliescu",slug:"laura-iliescu",fullName:"Laura Iliescu"}],corrections:null},{id:"75318",title:"Diagnosis of Nonalcoholic Steatohepatitis",doi:"10.5772/intechopen.96281",slug:"diagnosis-of-nonalcoholic-steatohepatitis",totalDownloads:248,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The prevalence of non-alcoholic fatty liver disease (NAFLD) has increased in the last years up to 25% in the adult population. This disease includes a large spectrum of disorders, from simple fatty liver disease to cirrhosis and Hepatocellular Carcinoma (HCC), and they are related to chronic metabolic conditions. NAFLD is characterized by the presence of at least 5% of hepatic steatosis without evidence of hepatocellular injury. The diagnosis of this disease should be of exclusion and focused on its progression, treatment, and identification of the prognosis. The European Association for the Study of the Liver (EASL), the National Institute for Health and Care Excellence (NICE), the Italian Association for the Study of the Liver (AISF), and the American Association for the Study of the Liver (AASLD), published their Clinical Guidelines that have identified the criteria for the diagnosis of NAFLD, several, using imaging or histological diagnostic methods, although they imply a different approach and screening. The Fatty Liver Index and the NAFLD Liver Fat Score are used by 3 out of 5 Guidelines and they are easily calculated using blood tests and clinical information. Other non-invasive scales for NAFLD are the NAFLD fibrosis score (NFS), Fib-4, AST/ALT ratio index; also the ELF panel, Fibrometer, Fibrotest, Hepascore; and some imaging techniques that include transient elastography, magnetic resonance elastography (MRE), and shear wave elastography. Finally, proteomic’s and glycomic’s technologic biomarkers are currently under investigation and recent use, such as Cytokeratin 18 and Sirtuin 1. Still, liver biopsy remains the gold standard to distinguish between steatohepatitis and simple steatosis, using the histological classification and staging scoring systems of NAFLD Activity Score (NAS) and the Steatosis Activity Fibrosis (SAF), to evaluate the disease’s activity.",signatures:"Eira Cerda-Reyes, Alicia Sarahi Ojeda-Yuren, Julián Torres-Vazquez, María del Rosario Herrero Maceda, Martín Uriel Vázquez-Medina, Perla Denice Flores-Rangel, Yailin Fabiola Velásquez Palacios, Saraid Cerda-Reyes and Graciela Elia Castro-Narro",downloadPdfUrl:"/chapter/pdf-download/75318",previewPdfUrl:"/chapter/pdf-preview/75318",authors:[{id:"303871",title:"Dr.",name:"Eira",surname:"Cerda",slug:"eira-cerda",fullName:"Eira Cerda"},{id:"303873",title:"Dr.",name:"Perla",surname:"Flores-Rangel",slug:"perla-flores-rangel",fullName:"Perla Flores-Rangel"},{id:"346060",title:"Dr.",name:"Saraid",surname:"Cerda-Reyes",slug:"saraid-cerda-reyes",fullName:"Saraid Cerda-Reyes"},{id:"346061",title:"Dr.",name:"Graciela Elia",surname:"Castro-Narro",slug:"graciela-elia-castro-narro",fullName:"Graciela Elia Castro-Narro"},{id:"346062",title:"Dr.",name:"Alicia",surname:"Ojeda-Yuren",slug:"alicia-ojeda-yuren",fullName:"Alicia Ojeda-Yuren"},{id:"346063",title:"Dr.",name:"Julian",surname:"Torres-Vázquez",slug:"julian-torres-vazquez",fullName:"Julian Torres-Vázquez"},{id:"346064",title:"Dr.",name:"Maria Del Rosario",surname:"Herrero-Maceda",slug:"maria-del-rosario-herrero-maceda",fullName:"Maria Del Rosario Herrero-Maceda"},{id:"346065",title:"Dr.",name:"Martín Uriel",surname:"Vázquez-Medina",slug:"martin-uriel-vazquez-medina",fullName:"Martín Uriel Vázquez-Medina"},{id:"346066",title:"Dr.",name:"Yailin Fabiola",surname:"Velásquez-Palacios",slug:"yailin-fabiola-velasquez-palacios",fullName:"Yailin Fabiola Velásquez-Palacios"}],corrections:null},{id:"76639",title:"Treatment of Nonalcoholic Fatty Liver Disease through Changes in Gut Microbiome and Intestinal Epithelial Barrier",doi:"10.5772/intechopen.97568",slug:"treatment-of-nonalcoholic-fatty-liver-disease-through-changes-in-gut-microbiome-and-intestinal-epith",totalDownloads:248,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Nonalcoholic fatty liver disease (NAFLD) is a leading liver disease worldwide with a prevalence of approximately 25% among adult population. The highest prevalence is observed in Middle East and the lowest prevalence in Africa. NAFLD is a spectrum of liver disorders ranging from simple steatosis to nonalcoholic steatohepatitis (NASH). Pro-inflammatory diet, overweight/obesity, inflammation, insulin resistance, prediabetes, type 2 diabetes, dyslipidemia, disrupted gut microbiome, and impaired intestinal barrier function are important risk factors associated with and/or contributing to NAFLD. Gut microbiome is a complex and diverse microbial ecosystem essential for the maintenance of human health. It is influenced by several factors including diet and medications. Gut microbiome can be disrupted in NAFLD. Intestinal epithelial barrier is the largest and most important barrier against the external environment and plays an important role in health and disease. Several factors including diet and gut microbiome impact intestinal barrier function. NAFLD can be associated with impaired intestinal barrier function (increased intestinal permeability). There are no specific drugs that directly treat NAFLD. The first-line therapy of NAFLD is currently lifestyle intervention. Weight loss is an important component in the treatment of NAFLD subjects who have excess body weight. Gut microbiome and intestinal epithelial barrier are becoming promising targets for the treatment of several diseases including NAFLD. In the absence of approved pharmacotherapy for the treatment of NAFLD/NASH, in addition to lifestyle intervention and weight loss (in case of excess body weight), focus should also be on correcting gut microbiome and intestinal permeability (directly and/or through gut microbiome modulation) using diet (e.g., low-fat diet, high-fiber diet, and Mediterranean diet), prebiotics (nondigestible food ingredients), probiotics (nonpathogenic living microorganisms), synbiotics (combination of prebiotics and probiotics), and fecal microbiota transplantation (transfer of healthy stool).",signatures:"Hassan M. Heshmati",downloadPdfUrl:"/chapter/pdf-download/76639",previewPdfUrl:"/chapter/pdf-preview/76639",authors:[{id:"313921",title:"Dr.",name:"Hassan M.",surname:"Heshmati",slug:"hassan-m.-heshmati",fullName:"Hassan M. Heshmati"}],corrections:null},{id:"75746",title:"The Role of Bariatric Surgery in Fatty Liver",doi:"10.5772/intechopen.96975",slug:"the-role-of-bariatric-surgery-in-fatty-liver",totalDownloads:189,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Non-alcoholic fatty liver disease (NAFLD) is a crucial health problem with a prevalence that is increasing concurrently with the obesity epidemic on a global scale. Steatosis, nonalcoholic steatohepatitis (NASH), hepatocellular carcinoma (HCC), cirrhosis, and advanced fibrosis constitute the disease spectrum covered by NAFLD. NASH-related cirrhosis and HCC is currently the second most common indication for liver transplantation. Although lifestyle modifications, especially weight loss, effectively reduces the liver injury in NASH, adherence in the clinical setting is low. Potential treatments for NASH are still under investigation in phase 2–3 studies. Bariatric surgery can improve metabolic components and cause great weight loss. Therefore, bariatric surgery may reverse the pathological liver changes in NAFLD and NASH patients. However, complications such as liver failure after bariatric surgery can occur. This chapter will give an overview of the benefits and pitfalls of bariatric surgery in patients with NAFLD, liver transplant candidates and post-liver transplant patients.",signatures:"Anja Geerts and Sander Lefere",downloadPdfUrl:"/chapter/pdf-download/75746",previewPdfUrl:"/chapter/pdf-preview/75746",authors:[{id:"331921",title:"Prof.",name:"anja",surname:"geerts",slug:"anja-geerts",fullName:"anja geerts"},{id:"331922",title:"Dr.",name:"Sander",surname:"Lefere",slug:"sander-lefere",fullName:"Sander Lefere"}],corrections:null},{id:"76103",title:"Spontaneous Bacterial Peritonitis: Physiopathological Mechanism and Clinical Manifestations",doi:"10.5772/intechopen.96910",slug:"spontaneous-bacterial-peritonitis-physiopathological-mechanism-and-clinical-manifestations",totalDownloads:392,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Changes in intestinal permeability have been determined to influence secondary inflammatory reactions and clinical manifestations such as spontaneous bacterial peritonitis (SBP) secondary to cirrhosis. As of yet, no in-depth exploration of the changes in the microbiota and how this influences cirrhosis to differ from clinically more severe cases than others has not begun. However, at the level of pathophysiological mechanism, it must be taken into account that due to the abuse of substances such as alcohol and chronic fatty liver disease, changes in the bacterial composition and intestinal permeability are induced. This set of changes in the bacterial composition (microbiome) and modification of the intestinal permeability could be related to the presence of ascites and spontaneous peritonitis secondary to cirrhosis, being of relevance the knowledge of the mechanisms underlying this phenomenon, as well as clinical manifestation. Prophylaxis and antibiotic treatment of SBP requires clinical knowledge for the treatment decisions based mainly on the presence of ascitic fluid, accompanied of risk factors, laboratory indexes such as PMN count and culture results, in order to determine the kind of molecule that will help to the SBP recovery or to amelioration symptoms, always taking care of not exceed the antibiotic consumption and restoring the microbiome imbalance.",signatures:"Rebeca Pérez-Cabeza De Vaca, Balasubramaniyan Vairappan, Tomás Cortés Espinoza, Juan Antonio Suárez Cuenca, Cuauhtemoc Licona Cassani, Brenda Maldonado Arriaga, Chrisitan Navarro Gerrard, Diana Selene Morgan Penagos, Paul Mondragón Terán and Victoria Chagoya De Sanchez",downloadPdfUrl:"/chapter/pdf-download/76103",previewPdfUrl:"/chapter/pdf-preview/76103",authors:[{id:"100474",title:"Dr.",name:"Victoria Chagoya De",surname:"Sanchez",slug:"victoria-chagoya-de-sanchez",fullName:"Victoria Chagoya De Sanchez"},{id:"276843",title:"Dr.",name:"Rebeca",surname:"Pérez-Cabeza De Vaca",slug:"rebeca-perez-cabeza-de-vaca",fullName:"Rebeca Pérez-Cabeza De Vaca"},{id:"342318",title:"Dr.",name:"Tomás",surname:"Cortés Espinoza",slug:"tomas-cortes-espinoza",fullName:"Tomás Cortés Espinoza"},{id:"342320",title:"Dr.",name:"Balasubramaniyan",surname:"Vairappan",slug:"balasubramaniyan-vairappan",fullName:"Balasubramaniyan Vairappan"},{id:"342321",title:"Dr.",name:"Juan Antonio",surname:"Suárez Cuenca",slug:"juan-antonio-suarez-cuenca",fullName:"Juan Antonio Suárez Cuenca"},{id:"342322",title:"Dr.",name:"Paul",surname:"Mondragón Terán",slug:"paul-mondragon-teran",fullName:"Paul Mondragón Terán"},{id:"342349",title:"Dr.",name:"Diana Selene",surname:"Morgan Penagos",slug:"diana-selene-morgan-penagos",fullName:"Diana Selene Morgan Penagos"},{id:"342350",title:"Dr.",name:"Chrisitan",surname:"Navarro Gerrard",slug:"chrisitan-navarro-gerrard",fullName:"Chrisitan Navarro Gerrard"},{id:"342712",title:"Dr.",name:"Brenda",surname:"Maldonado Arriaga",slug:"brenda-maldonado-arriaga",fullName:"Brenda Maldonado Arriaga"},{id:"342714",title:"Dr.",name:"Cuauhtemoc",surname:"Licona Cassani",slug:"cuauhtemoc-licona-cassani",fullName:"Cuauhtemoc Licona Cassani"}],corrections:null},{id:"76923",title:"Hepatorenal Syndrome",doi:"10.5772/intechopen.97698",slug:"hepatorenal-syndrome",totalDownloads:224,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Hepatorenal Syndrome (HRS) is an important condition for clinicians to be aware of in the presence of cirrhosis. In simple terms, HRS is defined as a relative rise in creatinine and relative drop in serum glomerular filtration rate (GFR) alongside renal plasma flow (RPF) in the absence of other competing etiologies of acute kidney injury (AKI) in patients with hepatic cirrhosis. It represents the end stage complication of decompensated cirrhosis in the presence of severe portal hypertension, in the absence of prerenal azotemia, acute tubular necrosis or others. It is a diagnosis of exclusion. The recognition of HRS is of paramount importance for clinicians as it carries a high mortality rate and is an indication for transplantation. Recent advances in understanding the pathophysiology of the disease improved treatment approaches, but the overall prognosis remains poor, with Type I HRS having an average survival under 2 weeks. Generally speaking, AKI and renal failure in cirrhotic patients carry a very high mortality rate, with up to 60% mortality rate for patients with renal failure and cirrhosis and 86.6% of overall mortality rates of patients admitted to the intensive care unit. Of the various etiologies of renal failure in cirrhosis, HRS carries a poor prognosis among cirrhotic patients with acute kidney injury. HRS continues to pose a diagnostic challenge. AKI can be either pre-renal, intrarenal or postrenal. Prerenal causes include hypovolemia, infection, use of vasodilators and functional due to decreased blood flow to the kidney, intra-renal such as glomerulopathy, acute tubular necrosis and post-renal such as obstruction. Patients with cirrhosis are susceptible to developing renal impairment. HRS may be classified as Type 1 or rapidly progressive disease, and Type 2 or slowly progressive disease. There are other types of HRS, but this chapter will focus on Type 1 HRS and Type 2 HRS. HRS is considered a functional etiology of acute kidney injury as there is an apparent lack of nephrological parenchymal damage. It is one several possibilities for acute kidney injury in patients with both acute and chronic liver disease. Acute kidney injury (AKI) is one of the most severe complications that could occur with cirrhosis. Up to 50% of hospitalized patients with cirrhosis can suffer from acute kidney injury, and as mentioned earlier an AKI in the presence of cirrhosis in a hospitalized patient has been associated with nearly a 3.5-fold increase in mortality. The definition of HRS will be discussed in this chapter, but it is characterized specifically as a form of acute kidney injury that occurs in patients with advanced liver cirrhosis which results in a reduction in renal blood flow, unresponsive to fluids this occurs in the setting of portal hypertension and splanchnic vasodilation. This chapter will discuss the incidence of HRS, recognizing HRS, focusing mainly on HRS Type I and Type II, recognizing competing etiologies of renal impairment in cirrhotic patients, and the management HRS.",signatures:"Arshpal Gill, Ra’ed Nassar, Ruby Sangha, Mohammed Abureesh, Dhineshreddy Gurala, Zeeshan Zia, Rachelle Hamadi and Suzanne El-Sayegh",downloadPdfUrl:"/chapter/pdf-download/76923",previewPdfUrl:"/chapter/pdf-preview/76923",authors:[{id:"274034",title:"Dr.",name:"Arshpal",surname:"Gill",slug:"arshpal-gill",fullName:"Arshpal Gill"},{id:"351017",title:"Dr.",name:"Ra'ed",surname:"Nassar",slug:"ra'ed-nassar",fullName:"Ra'ed Nassar"},{id:"351018",title:"Dr.",name:"Ruby",surname:"Sangha",slug:"ruby-sangha",fullName:"Ruby Sangha"},{id:"351019",title:"Dr.",name:"Abureesh",surname:"Mohammed",slug:"abureesh-mohammed",fullName:"Abureesh Mohammed"},{id:"351021",title:"Dr.",name:"Rachelle",surname:"Hamadi",slug:"rachelle-hamadi",fullName:"Rachelle Hamadi"},{id:"351022",title:"Dr.",name:"Dhineshreddy",surname:"Gurala",slug:"dhineshreddy-gurala",fullName:"Dhineshreddy Gurala"},{id:"351025",title:"Dr.",name:"Zeeshan",surname:"Zia",slug:"zeeshan-zia",fullName:"Zeeshan Zia"},{id:"351670",title:"Dr.",name:"Suzanne",surname:"El-Sayegh",slug:"suzanne-el-sayegh",fullName:"Suzanne El-Sayegh"}],corrections:null},{id:"75220",title:"Treatment Approach in Patients with Decompensated Liver Cirrhosis",doi:"10.5772/intechopen.96155",slug:"treatment-approach-in-patients-with-decompensated-liver-cirrhosis",totalDownloads:532,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Chronic liver disease and decompensated cirrhosis are the major causes of morbidity and mortality in the world. According to current data, deaths due to liver cirrhosis constitute 2.4% of the total deaths worldwide. Cirrhosis is characterized by hepatocellular damage that leads to fibrosis and regenerative nodules in the liver. The most common causes of cirrhosis include alcohol consumption, hepatitis C, hepatitis B, and non-alcoholic fatty liver disease. Dysbiosis and intestinal bacterial overgrowth play a role in the development of complications of cirrhosis through translocation. In liver cirrhosis, ascites, gastrointestinal variceal bleeding, spontaneous bacterial peritonitis infection, hepatic encephalopathy, hepatorenal syndrome, hepatocelluler carcinoma are the most common complications. In addition, there are refractory ascites, hyponatremia, acute on-chronic liver failure, relative adrenal insufficiency, cirrhotic cardiomyopathy, hepatopulmonary syndrome and portopulmonary hypertension. In the primary prophylaxis of variceal bleeding, non-selective beta blockers or endoscopic variceal ligation are recommended for medium and large variceal veins. In current medical treatment, vasoactive agents, antibiotics, blood transfusion, endoscopic band ligation are the standard approach in the treatment of acute variceal bleeding. Sodium-restricted diet, diuretics and large-volume paracentesis are recommended in the management of ascites. In the treatment of hepatic encephalopathy, lactulose, branched chain amino acids, rifaximin and L-ornithine L-aspartate can be used. New therapeutic approaches such as ornithine phenyl acetate spherical carbon and fecal microbiota transplantation have shown beneficial effects on hepatic encephalopathy symptoms. In addition to their antioxidative, anti-proliferative and anti-inflammatory properties, statins have been shown to reduce the risk of decompensation and death by reducing portal pressure in compensated cirrhosis. In the treatment of liver failure, some artificial liver devices such as molecular adsorbent recirculating system, the single albumin dialysis system, fractionated plasma separation and adsorption are used until transplantation or regeneration. The purpose of this chapter is to review the most up-to-date information on liver cirrhosis and to explain the complications assessment, current management and potential treatment strategies in decompensated cirrhosis.",signatures:"Anıl Delik and Yakup Ülger",downloadPdfUrl:"/chapter/pdf-download/75220",previewPdfUrl:"/chapter/pdf-preview/75220",authors:[{id:"315993",title:"MSc.",name:"Anıl",surname:"Delik",slug:"anil-delik",fullName:"Anıl Delik"},{id:"339352",title:"Dr.",name:"Yakup",surname:"Ülger",slug:"yakup-ulger",fullName:"Yakup Ülger"}],corrections:null},{id:"75658",title:"Therapy that Targets Growth Factor Receptors: Novel Approach for Liver Cirrhosis Treatment",doi:"10.5772/intechopen.96552",slug:"therapy-that-targets-growth-factor-receptors-novel-approach-for-liver-cirrhosis-treatment",totalDownloads:226,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The background of liver fibrous degeneration is excessive cell proliferation including hepatic stellate cells, inflammatory cells, fibroblasts and myofibroblasts. Often it is the consequence of increased growth factors and/or their receptors expression. Key contributors to the liver cell proliferation are EGFR, FGFR, PDGFR, VEGFR, TGFβR, the increased expression of which is indicated on in vitro and in vivo models of liver fibrosis and in patients who experienced fibrosis-accompanied liver diseases. Elimination of growth factors/suppression of their receptors is associated with the weakening/elimination of certain processes responsible for fibrogenesis. This chapter represents the evidences of the efficacy of growth factor receptors signaling downregulation for the suppression of liver fibrosis and cirrhosis and their individual manifestations. The data on established and experimental therapeutics – specific and multikinase growth factor receptor inhibitors which demonstrated antifibrotic and anticirrhotic activity under in vitro and in vivo models, are also presented.",signatures:"Halyna Kuznietsova and Olexandr Ogloblya",downloadPdfUrl:"/chapter/pdf-download/75658",previewPdfUrl:"/chapter/pdf-preview/75658",authors:[{id:"340572",title:"Ph.D.",name:"Halyna",surname:"Kuznietsova",slug:"halyna-kuznietsova",fullName:"Halyna Kuznietsova"},{id:"347403",title:"Dr.",name:"Olexandr",surname:"Ogloblya",slug:"olexandr-ogloblya",fullName:"Olexandr Ogloblya"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"932",title:"Acute Pancreatitis",subtitle:null,isOpenForSubmission:!1,hash:"b9e4aebaf0e8a2dd617fe38a5d3b2bff",slug:"acute-pancreatitis",bookSignature:"Luis 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Complications",isOpenForSubmission:!1,hash:"062521454256bb4a388ce6fd638dbf1a",slug:"pancreatitis-treatment-and-complications",bookSignature:"Luis Rodrigo Saez",coverURL:"https://cdn.intechopen.com/books/images_new/983.jpg",editedByType:"Edited by",editors:[{id:"73208",title:"Prof.",name:"Luis",surname:"Rodrigo",slug:"luis-rodrigo",fullName:"Luis Rodrigo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"4478",title:"Acute and Chronic Pancreatitis",subtitle:null,isOpenForSubmission:!1,hash:"4e7a1b71b21315524a24e78819fb7dd3",slug:"acute-and-chronic-pancreatitis",bookSignature:"Luis Rodrigo",coverURL:"https://cdn.intechopen.com/books/images_new/4478.jpg",editedByType:"Edited by",editors:[{id:"73208",title:"Prof.",name:"Luis",surname:"Rodrigo",slug:"luis-rodrigo",fullName:"Luis Rodrigo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6440",title:"Liver Research and Clinical Management",subtitle:null,isOpenForSubmission:!1,hash:"e4bbd66ccead286ab737f23feb053cf8",slug:"liver-research-and-clinical-management",bookSignature:"Luis Rodrigo",coverURL:"https://cdn.intechopen.com/books/images_new/6440.jpg",editedByType:"Edited by",editors:[{id:"73208",title:"Prof.",name:"Luis",surname:"Rodrigo",slug:"luis-rodrigo",fullName:"Luis Rodrigo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6061",title:"Ascites",subtitle:"Physiopathology, Treatment, Complications and Prognosis",isOpenForSubmission:!1,hash:"ead9b3e5c36413f9ff2c3129fbc57574",slug:"ascites-physiopathology-treatment-complications-and-prognosis",bookSignature:"Luis 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Helminthiasis",subtitle:null,isOpenForSubmission:!1,hash:"6f2002f4cb6e246a51ed8688e076db4d",slug:"human-helminthiasis",bookSignature:"Luis Rodrigo",coverURL:"https://cdn.intechopen.com/books/images_new/5388.jpg",editedByType:"Edited by",editors:[{id:"73208",title:"Prof.",name:"Luis",surname:"Rodrigo",slug:"luis-rodrigo",fullName:"Luis Rodrigo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5122",title:"Colorectal Cancer",subtitle:"From Pathogenesis to Treatment",isOpenForSubmission:!1,hash:"5ab8ff026cf9fbd8e3b0097d7f11fe2c",slug:"colorectal-cancer-from-pathogenesis-to-treatment",bookSignature:"Luis Rodrigo",coverURL:"https://cdn.intechopen.com/books/images_new/5122.jpg",editedByType:"Edited by",editors:[{id:"73208",title:"Prof.",name:"Luis",surname:"Rodrigo",slug:"luis-rodrigo",fullName:"Luis Rodrigo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6740",title:"Advances in Pancreatic Cancer",subtitle:null,isOpenForSubmission:!1,hash:"500360b038bf8561a30993b0ccb6de91",slug:"advances-in-pancreatic-cancer",bookSignature:"Luis Rodrigo",coverURL:"https://cdn.intechopen.com/books/images_new/6740.jpg",editedByType:"Edited by",editors:[{id:"73208",title:"Prof.",name:"Luis",surname:"Rodrigo",slug:"luis-rodrigo",fullName:"Luis Rodrigo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],ofsBooks:[]},correction:{item:{id:"82323",slug:"corrigentum-to-scientific-swift-in-bioremediation-an-overview",title:"Corrignedum to: Scientific Swift in Bioremediation: An Overview",doi:null,correctionPDFUrl:"https://cdn.intechopen.com/pdfs/82323.pdf",downloadPdfUrl:"/chapter/pdf-download/82323",previewPdfUrl:"/chapter/pdf-preview/82323",totalDownloads:null,totalCrossrefCites:null,bibtexUrl:"/chapter/bibtex/82323",risUrl:"/chapter/ris/82323",chapter:{id:"45227",slug:"scientific-swift-in-bioremediation-an-overview",signatures:"Ranjith N. Kumavath and Pratap Deverapalli",dateSubmitted:"October 10th 2012",dateReviewed:"March 18th 2013",datePrePublished:null,datePublished:"October 2nd 2013",book:{id:"3547",title:"Applied Bioremediation",subtitle:"Active and Passive Approaches",fullTitle:"Applied Bioremediation - Active and Passive Approaches",slug:"applied-bioremediation-active-and-passive-approaches",publishedDate:"October 2nd 2013",bookSignature:"Yogesh B. Patil and Prakash Rao",coverURL:"https://cdn.intechopen.com/books/images_new/3547.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"164249",title:"Dr.",name:"Yogesh",middleName:"Bhagwan",surname:"Patil",slug:"yogesh-patil",fullName:"Yogesh Patil"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"163692",title:"Dr.",name:"Ranjith",middleName:null,surname:"Kumavath",fullName:"Ranjith Kumavath",slug:"ranjith-kumavath",email:"rnkumavath@gmail.com",position:null,institution:{name:"Central University of Kerala",institutionURL:null,country:{name:"India"}}},{id:"167339",title:"Mr.",name:"Pratap",middleName:null,surname:"Devarapalli",fullName:"Pratap Devarapalli",slug:"pratap-devarapalli",email:"pratap66666@gmail.com",position:null,institution:{name:"University of Tasmania",institutionURL:null,country:{name:"Australia"}}}]}},chapter:{id:"45227",slug:"scientific-swift-in-bioremediation-an-overview",signatures:"Ranjith N. Kumavath and Pratap Deverapalli",dateSubmitted:"October 10th 2012",dateReviewed:"March 18th 2013",datePrePublished:null,datePublished:"October 2nd 2013",book:{id:"3547",title:"Applied Bioremediation",subtitle:"Active and Passive Approaches",fullTitle:"Applied Bioremediation - Active and Passive Approaches",slug:"applied-bioremediation-active-and-passive-approaches",publishedDate:"October 2nd 2013",bookSignature:"Yogesh B. Patil and Prakash Rao",coverURL:"https://cdn.intechopen.com/books/images_new/3547.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"164249",title:"Dr.",name:"Yogesh",middleName:"Bhagwan",surname:"Patil",slug:"yogesh-patil",fullName:"Yogesh Patil"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"163692",title:"Dr.",name:"Ranjith",middleName:null,surname:"Kumavath",fullName:"Ranjith Kumavath",slug:"ranjith-kumavath",email:"rnkumavath@gmail.com",position:null,institution:{name:"Central University of Kerala",institutionURL:null,country:{name:"India"}}},{id:"167339",title:"Mr.",name:"Pratap",middleName:null,surname:"Devarapalli",fullName:"Pratap Devarapalli",slug:"pratap-devarapalli",email:"pratap66666@gmail.com",position:null,institution:{name:"University of Tasmania",institutionURL:null,country:{name:"Australia"}}}]},book:{id:"3547",title:"Applied Bioremediation",subtitle:"Active and Passive Approaches",fullTitle:"Applied Bioremediation - Active and Passive Approaches",slug:"applied-bioremediation-active-and-passive-approaches",publishedDate:"October 2nd 2013",bookSignature:"Yogesh B. Patil and Prakash Rao",coverURL:"https://cdn.intechopen.com/books/images_new/3547.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"164249",title:"Dr.",name:"Yogesh",middleName:"Bhagwan",surname:"Patil",slug:"yogesh-patil",fullName:"Yogesh Patil"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}}},ofsBook:{item:{type:"book",id:"10528",leadTitle:null,title:"Digital Entrepreneurship",subtitle:null,reviewType:"peer-reviewed",abstract:"\r\n\tDigital entrepreneurship has become the central driver of wealth, growth, value and job creation. It involves less capital, more flexibility, leaner organization, and more elusive strategic objectives than regular entrepreneurship, but also a more detailed understanding of various digital technologies. The emergence of the digital economy and new technologies have unlocked significant opportunities for entrepreneurs, leading to the creation of innovative business models. With the emergence of the new technologies, digital enterprises are being established in a variety of sectors. Technology is impacting our everyday lives. We live in an era of digital disruption, where learning, communicating, innovating, and even entertaining are driven by technology and if entrepreneurs do not make an adequate business transformation to the new age, they may be forced to leave the market in a process known as “creative destruction”. In the face of rapid technological change and blurring industry boundaries, a key question is the same for both groups: How can competitive advantage be achieved and sustained in the ‘era of digital revolution’. Businesses are affected by disruptive forces that can seriously alter their survival. Stories of successful adaptation and stories of failure to adapt are common and present in the minds of successful business leaders.
\r\n\r\n\tThis book will help you understand why digital technologies are at the forefront of today’s entrepreneurship, give you familiarity with key characteristics of online and digital entrepreneurship and explain the importance of business transformation. The book provides insight into the emergence of digital entrepreneurship and business transformation, key concepts, business models, resources, skill and strategies needed to develop successful ventures founded around digital technologies.
\r\n\t
The idea of the possibility of a continuous spectrum of electron energies decay into a set of alternating allowed and forbidden bands in the direction of electron motion and wave propagation in the presence of spatial periodicity of the deformation field was for the first time proposed by Keldysh [1]. Periodic semiconductor structures with predetermined parameters of layers were called semiconductor superlattices. The wide interest to the problem of their creation appeared after the article was published in 1970 by Esaki and Tsu, who proposed to make such structures by changing the doping or composition of the layers [2]. The periods in such structures had values from 5 to 20 nm. The number of layers reached several hundred.
\nThe author [3] gave the definition of photonic crystals as materials whose crystal lattice has a periodicity of the permittivity leading to the appearance of the “forbidden” frequencies range, called the photonic band gap. Yablonovich [4] and John [5] proposed to create structures with a photonic band gap, which can be considered as an optical analog of the band gap in semiconductors. In this case, the forbidden band is the frequency range in which the existence of light in the inner part of the crystal is forbidden. The type of defect or disturbance of periodicity in this instance can be different. Such structures have to be created artificially in contrast to natural crystals. In this case, the size of the basic unit element of a photonic crystal should be comparable with the light wavelength. The manufacturing of such structures involves the use of electron-beam and X-ray lithography [6].
\nAs the advantage of such photonic crystals, the author [3] notes the possibility of an exact description of their properties that coincide with the experiment, in contrast to superlattices.
\nStructures with spatial periodicity of elements were also used in the microwave range to reduce the phase velocity of the wave in comparison with the speed of light in special waveguides, called delay-line structures [7]. The authors of [7] called them “a kind of artificial crystals, the cells of which have large sizes.”
\nDelay-line structures are used in various types of vacuum microwave electronics devices. The specificity of the delay-line systems is the choice of their basic elements from metals and the need to take into account in the design the possibility of passing the electron beam interacting with the field. Examples of periodic structures used in delay-line systems are “meander,” “counterpins,” systems with alternating diaphragms, and so on.
\nIn the microwave range, the photonic crystal can be realized both on waveguides with dielectric filling [8, 9] and on flat transmission lines with periodically changing stripe structure [10]. There are examples of the creation of photonic crystals in the optical, infrared, ultraviolet, microwave ranges. Creating a photonic crystal for the microwave range is the simplest. It should be noted that in the theoretical description of the properties of such structures, unlike, for example, from superlattices, it is not necessary to take into account the properties of transition layers, quantum size effects, the specificity of technological processes. This opens the possibility to more accurately examine the properties of photonic crystals associated with periodicity and, in particular, to use the results of a theoretical description to measure the parameters of their layers as a result of solving the corresponding inverse problem.
\nMaterials with the properties of photonic crystals are also known in nature. They include, for example, noble opal [11], spicules of natural biomineral crystals, the basal spicules of glass sea sponges [12]. The time-varying forbidden band for the frequency region in the vicinity of 6 GHz was observed in a solution with a chemical self-oscillating Briggs-Rauscher reaction characterized by the presence of periodically located regions with different permittivities [13].
\nThe results of theoretical analysis on the characteristics of one-dimensional microwave photonic crystals made on the basis of a rectangular waveguide and their experimental investigation are given, for example, in [14]. The one dimensionality of the crystal means that the dielectric structure that fills the waveguide has a periodicity of dielectric permittivity in one direction (along the wave propagation direction, along the Z axis). The authors of [14] studied structures in the form of alternating layers with high dielectric permittivity
Here \n
When continuity conditions are used on surfaces \n
where
\n\n\n
The authors of [14] proposed to obtain reflection and transmission coefficients using the generalized scattering matrix, which is a result of the application of continuity conditions on media boundaries. The results of measurements and calculation of the transmission coefficient (
To calculate the reflection
which connects the coefficients \n
The coefficients \n
Structure consisting of
where
\na transmission matrix of an
The reflection \n
When calculating
The following expressions are used to calculate the reflection |
The results of the theoretical and experimental investigation of the resonant features that appear in the allowed and forbidden bands of microwave photonic crystal in the case of creating periodicity disturbance are given in [18]. As a waveguide photonic crystal, a waveguide section with a structure that is periodically alternating layers of two types of dielectrics with different values of thickness and permittivity was used. The dimensions and materials of the layers were chosen in such a way that in the frequency range 8–12 GHz, two allowed and one forbidden band were observed for the propagation of electromagnetic waves. The parameters of the first and the last layers of the photonic crystal were the same. The results of calculating the power transmission coefficient |
The results of calculating the square of the modulus of the transmission coefficient of an electromagnetic wave through the 11-layer structure without disturbance (curve
From the results of the calculation presented in Figure 3, it follows that an increase of layers in number causes the decrease of the width of the first band gap completely located within the 3 cm wavelength range and the increase in the width of both the left and right allowed bands in this wavelength range. With a number of layers larger than 27, these changes are less than 10 MHz. This behavior of the characteristics of an electromagnetic propagation through a photonic crystal is due to the following circumstance. The allowed band has a “dissected” frequency response and consists of a set of resonances, the number of which is determined by the number of identical elements that form the photonic crystal. Therefore, the increase of the number of photon crystal layers causes the increase of the number of resonances determining the width of the allowed band and, consequently, its width increases. At the same time, the width of the forbidden band decreases. The Q-value of the resonances that form the allowed band, the so-called “allowed levels,” as follows from the results of calculations and experiments, is maximum near the lower and upper boundaries of the allowed band.
\nDependences of the width of the forbidden and left allowed bands on the number of layers of a photonic crystal without disturbance: □, ●—theoretical and experimental values of the width of the left-allowed band, ◊, ▲—theoretical and experimental values of the band gap width.
Figure 2 (curve
The one-dimensional waveguide photonic crystals consisting of 7 and 11 layers completely filling a cross-section of rectangular waveguide of a 3-cm wavelength were used in the experiments. The odd layers were made of Al2O3 ceramics (\n
In [19], the results of an investigation on the characteristics of a waveguide microwave photonic crystal made in the form of dielectric matrices with air inclusions are presented. Ceramics (Al2O3) with a large number of air inclusions and polystyrene were used as materials of dielectric layers. A waveguide photonic crystal consisting of 11 layers was studied in the frequency range 8–12 GHz (Figure 4a). Odd layers were made of Al2O3 ceramics (\n
Model of the photonic crystal: 1—layers of ceramics with square through holes, 2—polystyrene layers, 3—disturbance in the form of a polystyrene layer with changed thickness (a). The ceramics layer with square through holes (b).
On the basis of numerical modeling using the finite element method in the CAD ANSYS HFSS, the influence of the volume fraction of air inclusions on the amplitude-frequency characteristics of the transmission coefficient of a photonic crystal was studied. The volume fraction of air inclusions was controlled by changing the size of the holes \n
As follows from the results of numerical calculation of the amplitude-frequency characteristics of the transmission coefficient of a photonic crystal by the finite-element method in the absence of the periodicity disturbance in the photonic structure, the increase in the volume fraction of air inclusions in the ceramic layers leads to the shift of the forbidden band of the photonic crystal toward shorter wavelengths and to the decrease of its depth. The results of the calculation of the photonic crystal amplitude-frequency characteristics by the finite element method in the presence of the disturbance of the photonic structure periodicity in the form of a central polystyrene layer of different thickness are shown in Figure 5 (solid curves).
\nCalculated (continuous curves) and experimental (discrete curves) amplitude-frequency characteristics of the transmittance of a photonic crystal for various volume fractions of air inclusions with disturbed sixth polystyrene layer of 6.0 mm. The volume fraction of inclusions: 1–0, 2–8.5, 3–23.0 and 4–43.0%.
The presence of the disturbance of the photonic structure periodicity in the form of the change of the thickness of the central (sixth) polystyrene layer led to the appearance of a transmission peak in the forbidden band of the photonic crystal, the position of which is determined by the size of this disturbance.
\nMeasurement of the amplitude-frequency characteristic of the transmittance of the investigated photonic crystal in the 3 cm wavelength range was carried out using the Agilent PNA-L Network Analyzer N5230A. The results of experimental studies of the amplitude-frequency characteristics of the transmittance of a photonic crystal without disturbance and for different thicknesses of the disturbed polystyrene layer \n
The layers of investigated photonic crystals containing a large number of air inclusions can be considered as composite materials, which are dielectric matrices based on ceramics with fillers in the form of air inclusions. It is known that the dielectric properties of composite materials can be characterized by the value of the effective permittivity \n
To determine the effective permittivity \n
Figure 6 shows the frequency dependences of the power transmission coefficient of the photonic crystal with a different fraction of air inclusion in ceramic layers with the disturbed sixth polystyrene layer of thickness \n
Amplitude-frequency characteristics of the transmission coefficients of a photonic crystal calculated using the values of the effective permittivity
The dependence of the effective permittivity of the layers on the volume fraction of air inclusions, calculated from the solution of the inverse problem, coincides with the dependence described by Maxwell-Garnett ratio [20] with the error of 7.47%, the Bruggeman ratio [21] with the error of 4.50% and the Lichteneker ratio [22] with the error of 24.02%.
\nA distinctive feature of microwave photonic crystals is the ability to provide various functions necessary for the operation of microwave circuits [23, 24, 25, 26] with a relatively small number of elements that make up a photonic crystal. A small number of elements forming microwave photonic crystals is associated with the need for compactness of the devices created on their basis. It is of scientific and practical interest to create multielement microwave photonic crystals characterized by small dimensions. To solve this kind of problem, it is possible to use as a photonic crystal the structure that excites higher type waves whose wavelengths are substantially shorter than the wavelength in the waveguide of the main type, as suggested by the authors in [27]. Therefore, the dimensions of devices at higher type waves become significantly smaller than similar devices on the main type of the wave. In this regard, they can be called low dimensional. The results of studies of waveguide photonic crystals in the form of alternating dielectric layers (even elements) of a photonic crystal and thin metal plates (odd elements) partially overlapping the waveguide cross-section are presented in [27]. Between the plates and the wide walls of the waveguide, there were gaps. Each of the plates created gap of the same width along the entire length of the plate. The gaps between the odd metal plates and the waveguide were created at one of the wide walls of the waveguide and the gaps between the even metal plates and the waveguide at the opposite wide wall of the waveguide. In this case, the gap is a source of higher type waves, forming in its vicinity the so-called near field. The structure of the investigated low-dimensional waveguide microwave photonic crystal is shown in Figure 7. The following materials were used as the dielectric material: polystyrene (\n
Model of a photonic crystal:
Based on numerical simulation, using the finite element method in the CAD ANSYS HFSS, the influence of the thickness of dielectric layers, the gap width and the number of layers of the photonic crystal structure on the amplitude-frequency characteristics of the transmission and reflection coefficients of a photonic crystal was investigated.
\nThe finite-element method was used to calculate the amplitude-frequency characteristic of the transmission
Comparison of the results of calculations and experimental studies of a photonic crystal created in accordance with the model described above indicates their good qualitative agreement.
\nThe use of metal plates with gaps in the structure of a photonic crystal has made it possible to substantially reduce its longitudinal dimension to 12.25 mm, which is approximately five times smaller than the longitudinal dimension of a photonic crystal created on elements made of alternating layers of dielectrics with different permittivity.
\nThe disturbance of periodicity in a low-dimensional microwave photonic crystal, as well as in the ordinary one, should lead to the appearance of a defect (impurity) mode resonance. The theoretical definition of the conditions for its appearance and their experimental realization was described in [28]. A violation of the periodicity of a photonic crystal can be a different size of the central dielectric layer or a modified size of the capacitive gap of the diaphragm adjacent to the disturbed layer. In [28], the results of studies of the low-dimensional photonic crystals described above (the inset to Figure 8) are presented. The diaphragms of 50 μm thick were made of aluminum. The thickness of each dielectric layer in the photonic crystal without “disturbances” was 3 mm. Thus, the total longitudinal dimension of the crystal without breaking the periodicity was ~15 mm. Figure 8 shows the experimental and calculated using the ANSYS HFSS CAD the transmission coefficient
Calculated (dashed and doted curves) and experimental (solid curves) amplitude-frequency characteristics of transmittance
The measurements were carried out using the Agilent PNA-L Network Analyzer N5230A. Comparison of the calculations and measurements results indicates their qualitative agreement. The existing difference may be due to ignoring the attenuation in the waveguide walls, which is essential for higher types of waves.
\nAs follows from the results shown in Figure 8, the introduction of the disturbance in the form of a changed size of the central dielectric layer led to the appearance of a defect mode resonance and a significant change in the width and depth of the “forbidden” band. At the same time, the position of the defect mode on the frequency scale essentially depends not only on the thickness of the “disturbed” dielectric layer but also on the value of the capacitive gap of the diaphragms.
\nPeriodic structures based on resonators as retarding systems for vacuum microwave devices and microwave filters have been described as early as in the 1960s [28, 29]. They were intended to be used as delay-line structures in these devices, providing the optimal interaction of the electron beam with the electromagnetic wave. The investigated structure consists of periodically located metal resonant diaphragms at a distance
The scheme of the microwave photonic crystal, where
On the basis of numerical simulation using the finite element method in the CAD ANSYS HFSS, the influence of substrates with different dielectric permittivity on the microwave reflection and transmission coefficients of the structure was investigated. The amplitude-frequency characteristics of a photonic crystal made up of metal diaphragms deposited on a dielectric substrate with a through aperture for different widths of the aperture and the amplitude-frequency characteristics of a photonic crystal made up of diaphragms on dielectric substrates with apertures filled with a material with the permittivity \n
The photonic crystal based on diaphragms without dielectric substrates consisted of 6 aluminum diaphragms of 10 μm fixed between two layers of 2 mm polystyrene placed in a rectangular waveguide. The width and height of the apertures of the diaphragms of the photonic crystal were chosen equal to 14 and 1 mm, respectively. This provided the appearance on the frequency dependences of the transmission and reflection coefficients (the dashed curves in Figure 10a and b, respectively) in the frequency range 8–12 GHz of one allowed and one forbidden bands. The same figures show the results of measurements of the amplitude-frequency characteristics of a photonic crystal with a disturbance of periodicity (solid curves) in the form of a modified distance \n
Experimental amplitude-frequency characteristics of the transmission coefficient (a) and reflection (b) of a photonic crystal based on diaphragms without dielectric substrates in the case of the disturbance absence (curve
A comparison of the experimental dependences presented in Figure 10 with the results of the calculation of the amplitude-frequency characteristics of the photonic crystal based on diaphragms without dielectric substrates in the case of the disturbance presence and the disturbance absence with parameters corresponding to the experimental sample described above indicates good qualitative and quantitative agreement.
\nThe ability to control the amplitude-frequency characteristics of microwave photonic crystals opens the prospect of expanding their field of application. This possibility was considered, in particular, in [31]. The authors of [31] took the design of the microwave photonic crystal used in [32] as a filter. Polystyrene, ceramics Al2O3 (thickness of 1 mm) and polycrystalline yttrium-iron garnet (YIG) (thickness of 1 mm) were used as the material forming the photonic crystal layer. The control of the amplitude-frequency characteristics of the investigated structures by magnetic field is provided by the increase in the real part of the ferrite magnetic susceptibility under increasing magnetic field. This leads to the increase in the microwave field concentration in the ferrite and to the increase in the phase shift of the wave as it passes through the ferrite plate and, as a consequence, to the shift of the amplitude-frequency characteristic.
\nIn [33], the possibility of creating the waveguide photonic crystal with a tunable frequency position of a transparency window associated with the periodicity disturbance in the photonic crystal and with attenuation in this window controlled by
The arrangement of the photonic crystal and the
The control voltage regulated in the range 0–700 mV was applied to the
Experimental dependences of the square of the modulus (a, b) and phase (b, d) of the transmission (a, b) and the reflection (c, d) coefficients of electromagnetic radiation in the region of the transparency window of a photonic crystal for different values of the voltage on the
It is known that the ring-type structures demonstrate properties of a photonic crystal, such as the presence of forbidden and allowed bands. The band nature of the spectrum in such structures is provided due to multiple reflections from the inhomogeneity in the structure. Such devices in microstrip design are given in [34, 35]. The characteristics of such structures in waveguide design are given in [36]. The element of the type “metal pin with a gap” is used in them as inhomogeneity. This inhomogeneity provides the appearance of a resonant feature in the forbidden band of the system under investigation, called the defect mode resonance or “transparency window.” Accordingly, the blocking peak may appear in the allowed band (passband). Figure 13 shows the design of a microwave element based on diaphragm, the system of coupled frame elements with “pin with a gap” type inhomogeneity located 20 mm to the right of the diaphragm and the semiconductor
Model of the microwave element based on the diaphragm and the system of coupled frame elements containing inhomogeneity in the form of “pin with a gap” designs: 1—waveguide, 2—diaphragm, 3—aperture, 4—frame element, 5–7—inhomogeneities of “pin with a gap” type.
As it follows from the calculation results, the change in the conductivity of the control element from 10−3 to 105 S/m leads to a change in the transmission coefficient at 9.44 GHz, corresponding to the blocking peak, in the range −36.79 to −1.01 dB. The system whose construction was described above was investigated experimentally. The bias voltage applied to the
Different directions of practical use of the unique characteristics of microwave photonic crystals were considered in [25]. One of the common names of microwave photonic crystals is structures with a forbidden band. At the same time, it is known that, in addition to the forbidden band (an analog of the band gap in semiconductors), microwave photonic crystals demonstrated the frequency band in which the wave propagates, practically without attenuation. The authors of [37] proposed to use this property to create waveguide broadband matched loads. The problem of constructing such loads remains one of the topical problems in microwave radioelectronics at the present time. Matched microwave loads are widely used both independently and as elements of complex functional devices: directional couplers, summators, power meters, measuring bridges, microwave filters, and so on [38, 39].
\nThe results of studies of frequency dependences of the reflection coefficients of electromagnetic radiation from one-dimensional photonic crystals containing, along with periodically changing dielectric filling, nanometer metal layers are presented in [9, 10]. Computer simulations were carried to determine the possibility of using one-dimensional photonic crystals for creating matched loads. When calculating the reflection
The authors of [40] showed, as a result of solving the optimization problem, including the choice of the surface resistance of a nanometer metal film, that it was possible to create the matched load of the described above type with the voltage standing wave ratio (VSWR) not more than 1.1 in the frequency bands 8.15–12.05, 12.05–17.44 and 17.44–25.95 GHz. The longitudinal dimensions of the loads were less than 14.5, 10.0, 9.0 mm, respectively. For the frequency range 25.95–37.50 GHz (Figure 14), the VSWR of the created load was less than 1.15 with a longitudinal dimension of 6.5 mm.
\nExperimental frequency dependence of VSWR in the range 25.95–37.50 GHz.
It is known that reflection and transmission spectra of electromagnetic radiation can be used to measure the thickness and electrical conductivity of a semiconductor in metal-semiconductor structures [15, 16, 17]. The sensitivity of these methods depends significantly on how much these spectra are changed under changing the values of the semiconductor parameters. The determination of these parameters from the results of measurements of spectral dependences is called the solution of the inverse problem. The authors of [41] proposed to use for measurements of the parameters of nanometer metal layers on insulating substrates waveguide photonic structures in which the metal-dielectric structure was placed in a segment of a microwave photonic crystal that disturbed its periodicity. In the “forbidden” band of the photonic crystal, the transparency “window,” that is sensitive to the sought parameters of the metal-dielectric structure, is seen.
\nOne of the most successful and promising methods for diagnosing materials and structures that allow measurements with high spatial resolution is near-field microwave microscopy [42, 43, 44]. A key element of the near-field microwave microscope is a probe with an aperture size much smaller than the wavelength of the microwave radiation. In near-field microwave microscopes, the field of a non-propagating wave type is used as a probing source [16, 42, 43]. This field that is formed if the central conductor of the coaxial line goes beyond the outer conductor [15]. The authors [13] called the microwave resonator connected to the probe as the main element of the near-field microwave microscope, which provides to a greater extent its high sensitivity and resolution.
\nThe increase in the sensitivity of the resonator to the perturbation introduced into it through the probe causes the increase in the sensitivity and resolution of the microwave microscope as a whole.
\nThe design of the resonator in conjunction with the probe element for a near-field microwave microscope is described in [45]. In [46], the results of studying the possibility of using the one-dimensional photonic crystal in which a tunable resonator, serving as a load, allows to control the resonance features in the reflection spectrum of a near-field microwave microscope probe were presented. As such a load, the authors of [46] chose the cylindrical resonator with the coupling element extending beyond the cavity, the end of which is used as a probe of a near-field microscope to monitor the parameters of the dielectric plate with different values of the permittivity and the thickness of nanometer metal layers deposited on dielectric plates.
\nThe general view of the probe of a near-field microwave microscope on the basis of a cylindrical microwave resonator with the coupling frame element and the one-dimensional photonic crystal is shown in Figure 15.
\nProbe of a near-field microwave microscope based on a cylindrical microwave cavity
The probe based on the cylindrical resonator with a coupling frame element was connected to a segment of the waveguide photonic crystal 9 with the disturbance of the periodicity. The one-dimensional waveguide photonic crystal consisting of 11 layers was used in the frequency range 8–12 GHz. The odd layers were made of ceramics Al2O3 (\n
The tip of the probe approaching to the sample caused abrupt change in the input impedance of the probe and the reflection coefficient of the microwave wave from the probe. The magnitude of its change depends on the parameters of the test sample, such as electrical conductivity, permittivity, thickness.
\nFigure 16 shows the results of measurements of the frequency dependence of the microwave reflection coefficient in the vicinity of the resonant frequency at a fixed gap (18 μm) between the probe and the samples under study with different dielectric permittivity. Figure 16 shows the dependences of the microwave reflection coefficient measured at various fixed frequencies in the vicinity of the reflection coefficient minimum on the dielectric permittivity of the samples placed at a fixed distance near the tip of the probe.
\nFrequency dependences of the microwave reflection coefficient in the vicinity of the resonance frequency at a fixed gap equal to 18 μm between the probe and samples with different dielectric permittivity. Curve 1 corresponds to the absence of the measured sample (
The investigated resonance system can also be used to measure samples in the form of dielectric plates with nanometer metal layers of different thicknesses. Figure 17 shows the results of measurements of the frequency dependences of the microwave reflection coefficient in the vicinity of the resonance frequency at a fixed gap (18 μm) between the probe and the samples under study with different thicknesses of the nanometer metal layer (Cr) in the metal-insulator structure. The thickness of the deposited nanometer metal layers was measured using the Agilent Technologies AFM5600 atomic force microscope.
\nFrequency dependences of the microwave reflection coefficient in the vicinity of the resonance frequency at a fixed gap equal to 18 μm between the probe and the samples under study with different thicknesses of the nanometer metal layer Cr: (1) without metallization, (2)
The inset of Figure 17 shows the dependences of the microwave reflection coefficient measured at various fixed frequencies (10.77908, 10.77895 and 10.77850 GHz) in the vicinity of the reflection coefficient minimum on the thickness of the nanometer metal layer on ceramics
In [47], it is proposed to implement a method for simultaneous measurement of the substrate thickness of a semiconductor structure, the thickness and conductivity of a heavily doped epitaxial layer, the mobility of free charge carriers in this layer using a one-dimensional microwave photonic crystal. The one-dimensional waveguide photonic crystal consisted of 11 layers, forming a structure of periodically alternating elements, each of which included two layers, was considered. The measured structure, placed on the boundary of the disturbed central teflon layer and the next ceramics
Arrangement of the semiconductor structure relative to the disturbed layer in the waveguide microwave 8 photonic crystal: (1) heavily doped semiconductor layer, (2) high-resistance substrate, (3) disturbed central layer, (4) and (5) periodically alternating layers with different values of permittivity.
The investigated samples were epitaxial arsenide-gallium structures of thickness \n
The residual function \n
for the case when the thickness of the heavily doped GaAs layer was 13.14 μm, its electrical conductivity \n
The form of the residual function in space and the contour maps in the planes of the sought parameters
To determine the mobility of free charge carriers of semiconductor heavily doped layers, the investigated epitaxial semiconductor structure was placed in the E plane at the center of the cross section of a rectangular waveguide after a waveguide photonic crystal. The magnetic induction vector of the magnetic field \n
Arrangement of the photonic crystal and epitaxial semiconductor structure in the waveguide. 1—ceramics Al2O3 layer, 2—teflon layer, 3—disturbed teflon layer, 4—tested gallium arsenide structure, which includes: 5—high-resistance substrate, 6—heavily doped semiconductor layer.
To find the mobility of free charge carriers by frequency dependences \n
This chapter presents the results of theoretical and experimental studies of one-dimensional microwave photonic crystals based on rectangular waveguides characterized by the presence of forbidden and allowed bands for the propagation of electromagnetic waves. Methods for describing the electrodynamic characteristics of photonic crystals and their relationship with the parameters of periodic structures filling the waveguides have been presented. The change in the width of the allowed and forbidden bands of a photonic crystal has been described when a defect mode occurs because of the creation of the disturbance of the periodicity of the photonic crystal structure. The change in the amplitude-frequency characteristics of microwave photonic crystals has been considered. The types of disturbances and defect modes have been described. The results of the investigation on the characteristics of waveguide microwave photonic crystals created in the form of dielectric matrices with air inclusions have been presented. It has been shown that the layers of the investigated photonic crystals containing a large number of air inclusions can be considered as composite materials. New types of low-dimensional microwave waveguide photonic crystals containing periodically alternating elements that are the source of higher type waves have been described. The possibility of effective control of the amplitude-frequency characteristics of microwave photonic crystals by electric and magnetic fields has been analyzed. The examples of applications of waveguide microwave photonic crystals such as methods for measuring the parameters of materials and semiconductor nanostructures that play the role of periodicity disturbance of the microwave photonic crystals; resonators of near-field microwave microscopes; small-sized broadband matched loads of centimeter and millimeter wavelengths ranges based on microwave photonic crystals have been given.
\nThe research was carried out with the financial support of the Ministry of Education and Science of the Russian Federation (state task №8.7628.2017/BCH).
\nThe cetaceans are fully aquatic mammals with 89 species recognized by the Society of Marine Mammalogy Committee on Taxonomy [1]. The artiodactylian ancestors moved to aquatic life about 50 million years ago [2] and at present some relatives, like hippopotamuses, are semi-aquatic.
The adaptation to the new media, under the water, induced several changes in the morphology of the eyes. Although anatomy and functional vision have been studied in the odontocetes like dolphins and orca (cetaceans with teeth), limited studies have been done on mysticete eyes, the larger cetaceans (with baleen). Moreover, very few studies have been done on the molecular distribution and ultrastructure of the retina. In the present chapter, we will summarize the main results of our group on the structure of the eyes of two large fin whales (18 meters large and 20 tons in weight) that beached on the Cantabric coast of Spain; they died a few hours after beaching, but this allowed us to study the eye in perfect morphological details and some biochemical analysis. Since the eyes of both fin whales had similar size and the animals were of the same sex, we will discuss both without distinction. Both specimens were adult males; one was
The results shown in the present chapter are based on anatomical, histologic, immunohistochemical and electron microscopy studies performed during the last 2 years that have partially been published in several articles [3, 4, 5]. The methodology was explained in those articles. Here, we will concentrate on explaining the conclusions of how our research has helped us understand how the whales see.
The first anatomical discovery was the size of the eye. Even though it was very small in proportion to the large body size of the animal, the whale eye was huge. When compared with other terrestrial mammals, it weighs 1 kilogram and is almost 13 cm in diameter. The shape of the eyeball was markedly flattened on the anterior segment compared with the spherical shape of the terrestrial mammals. As a result, the axial length of the eyecup was smaller than its diameter is close to a hemisphere. The eyes were located, as in other mysticetes, in the oral commissure. Two very thick eyelids protect the eye. The eyelids lack eyelashes that would not function under water (Figure 1A–D). Due to the adaptation to the big body size, and to resist the high pressures, the sclera was very thick, and was 4 cm in the thickest posterior part of the eye. Its composition was mainly collagen indicating that even when its texture is like bone the composition lacks hydroxyapatite [3]. Encapsulated sensory corpuscles were found in the sclera in groups in the proximity of the iridocorneal angle. It has been suggested that this corpuscle within the cetacean eye may function as pressure receptors, possibly to control intraocular pressure [6, 7].
(A) Eye and upper eyelid. Note the oval shape of the cornea and the round iris. (B) Detailed of the cavernous tissue surrounding the optic nerve. (C) Transversal section of the cornea and location of the round crystalline in the Centre. Note that the cornea is flat and thicker in the periphery than in the Centre. (D) Section of the eye showing the thick sclera, and the hemispheric retina and its vascularization. (E) Detail of the retina vascularization with parallel vessels.
The cornea was an elongation of the sclera that becomes transparent only in the most anterior part of the eye. The thickness of the cornea was not uniform. The cornea was thinner in the centre and thicker at the periphery with a peripheral rim of almost 4 mm thick while the central part was 2 mm. Moreover, the cornea in the central part of the eye was flattened, another adaptation to vision underwater [3]. The cornea in the case of these cetaceans acted as a weak divergent lens and the refractive index is very little different from that of the water (Figure 1C). Therefore, in cetaceans, light refraction and focusing of an image on the retina are almost entirely performed by the lens [8]. The intraocular lens, the crystalline, in these mysticetes was almost spherical similar to that in fishes and measured 2 cm in diameter. It was placed in the centre of the eyecup so that light coming from any direction is focused on the retina. The curvature of the lens surface provides sufficient refractive power to focus images on the retina. Thus, the optics of these cetaceans are similar to those of fish, reflecting the adaptation to the common environment and optical properties of the vision under the water. The very viscous vitreous body filled the vitreous chamber and as in fish, this viscosity is an adaptation to equilibrate the refraction.
The adaptation of the cetacean vision, from the deep underwater where the light is very low to a rapid change of brightness at the surface of ocean when the animal dives into the well-lit water surface, is perhaps due to the iris structure and its pupil shape. Most cetaceans have a special pupil with a U-shaped slit, however, the two mysticetes studied had the pupil oval and horizontally elongated with dimensions of 5 x 3 cm (Figure 1A). Several studies on the refraction index in the cetacean eyes, and especially in dolphins, had evoked the conclusion that the refractive index between the air and the cornea should make the cetacean eye catastrophically myopic (near-sighted) in air. However, this myopia is countered by the presence of flattened cornea [9]. The constriction of the iris and pupil shape can provide a correction of aerial myopia. Another adaptation of the cetacean eyes to conditions of low luminosity is a highly developed reflective layer, the tapetumlucidum, which lies behind the retinal pigment epithelium within the choroid. The tapetum in cetaceans has been described previously by [10]. We found a well-developed tapetum in the present two mysticetes studied. Its tapetum is formed with extracellular collagen fibrils and covers the complete fundus. What is unusual in the terrestrial mammals that live and hunt during the night is that the tapetumlucidum does not usually extend below the horizontal equator of the eye.
The eyes have strong extraocular muscles that cover a large cavernous tissue refilling the space that forms the sclera in the back of the eye and it surrounds the optic nerve with a conical shape. The cavernous tissue is also named by other authors as vascular plexus, rete ophthalmica and musculus retractor bulbi is speculated to function as a vascular rete to supply both heat and oxygen during dives [11]. A great number of blood vessels were surrounded by elastic fibers, smooth muscle and fat (Figure 1B). The function of this tissue could be to protect the optic nerve from the cold water and warm it and propel the eye outwards thereby helping with the focus. The massive musculus retractor bulbi, which produces axial displacements of the globe of the eye within the orbit, has been observed in other animals, mainly non-mammals like amphibians and the whale shark, and other cetaceans. However, the theory purposed by Kröger and Kirschfeld for dolphins in 1989, about the possibility that the focus could be based on shifting the lens backward due to the changes in the intraocular pressure, are very unprovable mechanism for whales, because of the very thick sclera (4 cm), that surrounds the retina, will protect the inner part of the eye from deforming and thus would be impossible to move the lens. We believe that the filling of the rete will increase necessary pressure to move the eyeball outwards. The retractor muscle will accompany the outward movement and when the rete is emptied the eye returns to the interior of the orbit. During this movement, the thick sclera will protect the eyeball from deforming forces. This could provide a mechanism to increase the field of vision when the eye protrudes. However, we do not believe that the lens will modify its position due to the propulsion of the eye.
The macroscopic view of the retina showed a dichotomous vascularization similar to that in a horse but in this case, it was holangiotic (Figure 1D, E). The vasculature had a radial distribution for the whole extension of the retina as previously described [12]. The shape of the retina is an incomplete hemisphere and a peripheral rim of the retina is bent inward (Figure 1D).
The thickness of the retina in cross-sections was not thicker than the human or pig retina. The number of rows of photoreceptors was 6–8 in the outer nuclear layer of the retina, however, the inner layers were thinner with less cellularity especially noticeable were the scarce and larger RGCs that were between 26.5 and 112.9 micrometers in diameter (Figure 2A) [4].
(A) Immunostaining of a retina section. Red neurofilaments labels the large retinal ganglion cell and their branches. In blue DAPI, staining shows the 6–7 layers of photoreceptors in the upper part of the picture. (B) Flat mount of the retina showing a melanopsin positive retinal ganglion cell. (C) immunostaining of a retina section. In red, the Müller glial cells are stained with antibodies against vimentin.
A detailed study of the photoreceptors showed that these species of mysticetes do not have cones. We used several antibodies to identify the different opsins, like rhodopsin, M/L opsin and S opsin as well as antibodies against rat and human cone arrestin. The only positive result was with rhodopsin, which specifically was present in rods. We conclude that in our study, the cone opsins that terrestrial animals used were not present in the whale retinas [4]. Previous studies demonstrated the monochromacy in some cetaceans and several mutations in the opsin gene sequences suggesting evolutionary modification of the cone cell function. In some cases, the cone structures have been partially maintained but with the absence of outer and inner segments [13]. Recent studies in other species of cetacean have found that cones have been adapted to other use, and instead of having visual pigments, like cone-opsins, they contain two proteins involved in magneto sensation, suggesting the possibility of an alternative functional role in responding to changes in geomagnetic fields [14].
Once the light impacts the photoreceptors, the next cells responsible for the transmission of the visual impulse within the retina are the bipolar and amacrine cells. We found that even when the cones’ opsins were not present, bipolar and amacrine cells maintained their molecular signals as well as location. The same results were found using electroretinograms to measure the electrical response to the light of these interneurons. [15] found that the cetaceans rod monochromat has both On and OFF bipolar cell pathways. The next step within the retina is the cells that are responsible to communicate the eye with the brain. These are the retinal ganglion cells (RGCs). The density of these cells was very low, lower than in any cetacean studied earlier [4], confirming the low resolution of that the whales’ retina. It appears that relatively few RGCs may have to integrate the information from a great number of photoreceptors that are abundant. We did not count the number of photoreceptors, however, considering the large size of the eye and the number of rows of rods, the proportion of information that the RGCs have to integrate is massive. Even when the RGCs were scarce in number, the size of the cell bodies was 3 times larger than in humans, with some cells reaching 100 micrometers (Figure 2A).
Besides the RGCs that integrate the visual inputs and send this information to the visual centres of the brain for processing, other specific type of cells are located in the retinal ganglion cell layer that does not transmit information to the image forming visual area of the brain. These specific cells only transmit information regarding light intensity to the brain and are areas responsible for controlling the circadian rhythms and pupillary light reflexes. We have been the first research group to describe them in cetaceans. These cells are melanopsinipRGCs [4]. They form a mosaic that covers the complete area of the retina and were more abundant in the centre of the retina and reduce in density toward the periphery (Figure 2B). There are at least six types of ipRGCs and in the whale’s retinas, we identify three types, the M1, M2 and M3 although the majority of them were M2. As per comparison in rodent retina, the number of M1 is higher than M2 or M3 [16]. In humans, M1d ipRGC is the predominant subtype [17]. These differences between species may be due to the different roles of the ipRGC subtypes. M1 projects to approximately 15 brain targets not involved in image forming activities, projecting predominantly to the suprachiasmatic nucleus (SCN) and to the olivary pretectal nucleus (OPN) to control pupillary light reflex [18, 19]. However, M2 ipRGCs that were the predominant ones in the whales´ retinas project mostly to the OPN and relatively fewer to the SCN suggesting that the control of the pupillary light reflex is very important for the whale [4].
In addition to neurons, there are glial cells in the retina that develop a very important role. The glia cells in cetacean’s retinas were slightly different to other mammals. Thus, the astrocytes had a punctate pattern surrounding the large arteries of the retina but due to the very large and strong blood vessels, they were seldom visualized embracing the vessels as they typically do in other mammalian retinas. The Müller glia was very robust and with the same morphology as in other mammalian retinas (Figure 2C). They had the capacity to facilitate the elongation of the RGC axons [20] and for that reason, we had immortalized the whale’s Müller glia for further study [5]. We also studied the microglial cells, which are the immune cells within the retina. They are present but were larger and more diffused. These differences with the terrestrial mammals could be related to the metabolism of the cetacean retina. For further discussion on the glial cells, see Ref. [4].
The optic nerve was 1 cm in diameter, small in comparison with the large size of the eye. The axons in the optic nerve were mainly ‘Giant’ (greater than 15micrometres in diameter) corresponding to the very large RGCs found in the retina. The size of the axons and cells is a common plesiomorphic character of cetaceans rather than being related to the large body size of these animals. This interpretation is supported by the comparison with other large terrestrial species. Thus, in elephants there are no Giant RGCs’ despite the large size of the animals [21], indicating that this has been an adaptation to the aquatic environment.
The high astroglial content in the cetacean nerve could be due to the highly developed metabolic support that the central nervous system required to sustain nervous activity during anaerobic and energy-demanding tasks like prolonged apnea [22]. The bigger the diameter of the axons is, the faster the impulse travels [23]. There was considerably more astroglia in the cetacean optic nerve than inland mammals, with astrocyte processes and myelin occupying a higher proportion of the nerve [4].
Similar characteristics of adaptation to the aquatic vision as described in the present study, have been found in other mysticetes of smaller size humpback and Bryde’s whales [24] or in Gray whale [25] aquatic mammals.
The described characteristics of the cornea play a minor role under the water because of its mall curvature and refractive indices of the media in front (seawater) and behind the cornea (aqueous humor). Although some refraction cannot be neglected especially due to the thickness [26]. The spatial resolving power of the cetaceans is very low compared to that of terrestrial mammals. Computing the peak of RGC density values range indicates that it is approximately 1 to 5 cycles/degree [24], compared for example with the horse that is approximately 20 cycles/degree [27], or the giraffe with approximately 20 cycles/degree [28].
Due to the large numbers of rod photoreceptors, and the few RGCs, it seems that for the cetaceans the sensitivity to the light is far more important than the resolution. A rod-vision provides better underwater vision in conditions where light intensity is low and light is scattered with increasing depth and rod dominance animals are more rapid to dark adaptation. Marine mammals use vision primarily in low light levels, where color vision may be of secondary importance. We believe that Peichl’s comments are very appropriate in this regard ‘the ocean for the whales is not blue’ [29]. Moreover, the very well developed melanopsin RGCs network indicates that the sensibility to the changes in light is highly preserved and the control of the pupil is very important to reduce the amount of light that penetrates the retina thus, as a pinhole camera they could see better the object that it wants to see. The mechanism which protrudes the eye with the cavernous tissue together with the retractor bulbils muscle allows them to move the eye forward and backwords. This could facilitate the whales to focus when the eye is protruded outward and be protected from the cold temperatures when in the deep ocean waters where the eye is moved inside the orbit and covered by the eyelids.
The large whales’ studies have been adapted to the underwater vision by a pupil that regulates the variations in luminosity together with the optic tapetum. The retina is similar to that of nocturnal terrestrial mammals with the absence of cones and large size of ganglion cells, separated by wide intercellular spaces, but a very well developed melanopsin system provides an adaptation for vision in low light environments. Thus, despite their eye large size, the retinal resolving power in cetaceans is generally weaker than in terrestrial mammals, due primarily to their low density of retinal ganglion cells.
This study was supported by ELKARTEK (KK-2019/00086), MINECO-Retos (PID2019-111139RB-I00), Grupos UPV/EHU (GIU 2018/150), and Proyectos de InvestigaciónBásica y/o Aplicada (PIBA_2020_1_0026) to EV, Basque Government postdoctoral grant (POS_2020_2_0031) to XP and UPV/EHU postdoctoral grant (ESPDOC20/058) to NR. We would like to thank the organizations AMBAR and CEPESMA for their support in getting the whales’ eyes in the best possible conditions.
The authors declare no conflict of interest.
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Design/methodology: The paper applied vector error correction model (VECM) Granger casualty test for assessing the direction of causality and variance decomposition to explain the magnitude of the forecast error variance determined by the shocks to each of the explanatory variables over time. LB (Q-stat) test is to determine data properties and WILD test is to assess short run causality from independent variables to dependent variable. Findings: The study results revealed that variables are integrated in the same order. The results of Johansen Juselius cointegration tests indicate that there is a unique long-term or equilibrium relationship among variables. Again, Granger causality test revealed that short run unidirectional causality are running from carbon dioxide emission to exports, GDP to import, and from import to carbon dioxide emissions. Variance decomposition function shows that the positive shocks in error term will produce positive effects on all variables in the long run. Therefore, a concerted effort from all national and international stakeholders, i.e., enterprises, consumers, and governments are expected to take measures to offset carbon emission and pursue environment-friendly trade plan for better managing the cities and regions in order to fight against global warming and climate change risk.",book:{id:"6075",slug:"management-of-cities-and-regions",title:"Management of Cities and Regions",fullTitle:"Management of Cities and Regions"},signatures:"Farhana Ferdousi and Md. Qamruzzaman",authors:[{id:"198685",title:"Dr.",name:"Farhana",middleName:null,surname:"Ferdousi",slug:"farhana-ferdousi",fullName:"Farhana Ferdousi"},{id:"217382",title:"Mr.",name:"Md",middleName:null,surname:"Qamruzzaman",slug:"md-qamruzzaman",fullName:"Md Qamruzzaman"}]},{id:"58316",doi:"10.5772/intechopen.72028",title:"Immigration and Social Inclusion: Possibilities from School and Sports",slug:"immigration-and-social-inclusion-possibilities-from-school-and-sports",totalDownloads:1275,totalCrossrefCites:2,totalDimensionsCites:2,abstract:"Immigration is a manifestation of cultural pluralism that crosses a transversal form, an important part of the western societies, generating consequences in political, social and cultural terms. Likewise, the evidence shows that the educational system attached to sport can be a positive context to promote inclusive processes associated to the immigrant population, due to its high social transcendence and its universal character. On the other hand, sports may act as a tool for social and cultural conflict if they focus on the imposition of a dominant culture or exacerbates the competitive sense. The present chapter has by objective to analyze the possibilities of sports as a tool for the social inclusion of the immigrant population, giving special emphasis to the educational options that were offered by the sport practice in the school context. To do this, it presents an important number of theoretical and empirical backgrounds associated with this topic, which will allow the reader to understand the existing relationship between sport, education and immigration, exposing their possible risks and virtues.",book:{id:"6357",slug:"immigration-and-development",title:"Immigration and Development",fullTitle:"Immigration and Development"},signatures:"Bastian Carter-Thuillier, Victor López-Pastor, Francisco Gallardo-\nFuentes and Juan Carter-Beltran",authors:[{id:"212425",title:"Dr.",name:"Bastian",middleName:null,surname:"Carter-Thuillier",slug:"bastian-carter-thuillier",fullName:"Bastian Carter-Thuillier"},{id:"214391",title:"Dr.",name:"Victor",middleName:null,surname:"Lopez-Pastor",slug:"victor-lopez-pastor",fullName:"Victor Lopez-Pastor"},{id:"214392",title:"Dr.",name:"Francisco",middleName:null,surname:"Gallardo",slug:"francisco-gallardo",fullName:"Francisco Gallardo"},{id:"214393",title:"Dr.",name:"Juan",middleName:null,surname:"Carter-Beltran",slug:"juan-carter-beltran",fullName:"Juan Carter-Beltran"}]},{id:"58382",doi:"10.5772/intechopen.72063",title:"Social Capital as Survival Strategy for Immigrants in South Africa: A Conceptual Framework",slug:"social-capital-as-survival-strategy-for-immigrants-in-south-africa-a-conceptual-framework",totalDownloads:1409,totalCrossrefCites:1,totalDimensionsCites:2,abstract:"Social survival strategies are premised on relations anchored around ethnicity, culture, nationality, and language. Out of this strategy is the concept of social capital which is defined as the link that allow people to discover opportunities as well as employment based in social relationships with previous migrants. There is no doubt that foreign nationals utilise different forms of social capital to achieve different means—the reliance on family at the point of entry to access shelter and employment opportunities whereas they access friendships and networks within the employment circles to access other employment opportunities. The aim of this research is to detail how foreign nationals employ social capital networks as a survival strategy in South African urban townships using Diepsloot, found in the northwest of Johannesburg, as a case study. It is an important study because there is a lack of literature linking social capital as a survival strategy. We focus on social capital because it is a propeller—at least at initial and transition stages of migration—to access other forms of survival strategies. This paper, before all else, derives a conceptual framework that should guide the empirical part of such a research.",book:{id:"6357",slug:"immigration-and-development",title:"Immigration and Development",fullTitle:"Immigration and Development"},signatures:"Nosipho Hlatshwayo and Kambidima Wotela",authors:[{id:"212717",title:"Dr.",name:"Kambidima",middleName:null,surname:"Wotela",slug:"kambidima-wotela",fullName:"Kambidima Wotela"},{id:"212719",title:"Ms.",name:"Nosipho",middleName:null,surname:"Hlatshwayo",slug:"nosipho-hlatshwayo",fullName:"Nosipho Hlatshwayo"}]},{id:"56489",doi:"10.5772/intechopen.70158",title:"The Economic Geography of Most North‐Western Region of Spain: Galicia and the Effect of Market Access on Regional Development Levels",slug:"the-economic-geography-of-most-north-western-region-of-spain-galicia-and-the-effect-of-market-access",totalDownloads:1200,totalCrossrefCites:1,totalDimensionsCites:2,abstract:"This chapter estimates the nominal wage equation of the geographical economics literature using data on the Galician regions over the period 2003–2013. The results of the estimations show the existence of a spatial wage structure across the Galician regions with a clear West‐East gradient. Additionally, we have controlled for the inclusion of potential covariates that might be influencing the levels of regional per capita income such as educational attainment levels and technological levels. The results are robust to these alternative estimations",book:{id:"6075",slug:"management-of-cities-and-regions",title:"Management of Cities and Regions",fullTitle:"Management of Cities and Regions"},signatures:"Jesús López‐Rodríguez and Guillermo Manso‐Fernández",authors:[{id:"141386",title:"Prof.",name:"Jesús",middleName:null,surname:"López-Rodríguez",slug:"jesus-lopez-rodriguez",fullName:"Jesús López-Rodríguez"},{id:"207335",title:"Ph.D.",name:"Guillermo",middleName:null,surname:"Manso-Fernandez",slug:"guillermo-manso-fernandez",fullName:"Guillermo Manso-Fernandez"}]},{id:"57815",doi:"10.5772/intechopen.71773",title:"Welfare Dependency Among Immigrants to Norway: A Panel Data Study of Transfer Shares",slug:"welfare-dependency-among-immigrants-to-norway-a-panel-data-study-of-transfer-shares",totalDownloads:973,totalCrossrefCites:1,totalDimensionsCites:1,abstract:"Using Norwegian panel data, we specify and estimate transfer share equations for immigrants belonging to different subgroups. The share measures how import transfers are relative to a gross income concept incorporating transfers and gross income coming from labor market participation. For both genders, we consider three types of immigrants: refugees, individuals immigrating for reunification with refugees and individuals immigrating because of work. The transfer share for an individual depends on different characteristics of it. The explanatory variables we consider are related to age, duration of stay in Norway, family composition, educational attainment and area of geographical residence in Norway. Unobserved individual-specific heterogeneity is represented by random effects. Of special concern, not at least from a policy point of view, is the effect of duration of stay on the transfer shares. For refugees and individuals reunifying with refugees we find, at least for a substantial number of years, that the transfer share decreases as the duration of stay becomes longer. An essential part of the analysis is that we compare the effects across gender. Among the refugees we find that the effect of duration of stay is quite similar for men and women.",book:{id:"6357",slug:"immigration-and-development",title:"Immigration and Development",fullTitle:"Immigration and Development"},signatures:"Tom Kornstad and Terje Skjerpen",authors:[{id:"193167",title:"Mr.",name:"Terje",middleName:null,surname:"Skjerpen",slug:"terje-skjerpen",fullName:"Terje Skjerpen"},{id:"213983",title:"Dr.",name:"Tom",middleName:null,surname:"Kornstad",slug:"tom-kornstad",fullName:"Tom Kornstad"}]}],mostDownloadedChaptersLast30Days:[{id:"57322",title:"Export, Import, Economic Growth, and Carbon Emissions in Bangladesh: A Granger Causality Test under VAR (Restricted) Environment",slug:"export-import-economic-growth-and-carbon-emissions-in-bangladesh-a-granger-causality-test-under-var-",totalDownloads:1399,totalCrossrefCites:2,totalDimensionsCites:2,abstract:"Purpose: This paper examines the causal and cointegrating relationship between economic growth and CO2 emissions in a multivariate framework by including imports and exports as others control variables for an emerging economy like Bangladesh. Design/methodology: The paper applied vector error correction model (VECM) Granger casualty test for assessing the direction of causality and variance decomposition to explain the magnitude of the forecast error variance determined by the shocks to each of the explanatory variables over time. LB (Q-stat) test is to determine data properties and WILD test is to assess short run causality from independent variables to dependent variable. Findings: The study results revealed that variables are integrated in the same order. The results of Johansen Juselius cointegration tests indicate that there is a unique long-term or equilibrium relationship among variables. Again, Granger causality test revealed that short run unidirectional causality are running from carbon dioxide emission to exports, GDP to import, and from import to carbon dioxide emissions. Variance decomposition function shows that the positive shocks in error term will produce positive effects on all variables in the long run. Therefore, a concerted effort from all national and international stakeholders, i.e., enterprises, consumers, and governments are expected to take measures to offset carbon emission and pursue environment-friendly trade plan for better managing the cities and regions in order to fight against global warming and climate change risk.",book:{id:"6075",slug:"management-of-cities-and-regions",title:"Management of Cities and Regions",fullTitle:"Management of Cities and Regions"},signatures:"Farhana Ferdousi and Md. Qamruzzaman",authors:[{id:"198685",title:"Dr.",name:"Farhana",middleName:null,surname:"Ferdousi",slug:"farhana-ferdousi",fullName:"Farhana Ferdousi"},{id:"217382",title:"Mr.",name:"Md",middleName:null,surname:"Qamruzzaman",slug:"md-qamruzzaman",fullName:"Md Qamruzzaman"}]},{id:"58382",title:"Social Capital as Survival Strategy for Immigrants in South Africa: A Conceptual Framework",slug:"social-capital-as-survival-strategy-for-immigrants-in-south-africa-a-conceptual-framework",totalDownloads:1409,totalCrossrefCites:1,totalDimensionsCites:2,abstract:"Social survival strategies are premised on relations anchored around ethnicity, culture, nationality, and language. Out of this strategy is the concept of social capital which is defined as the link that allow people to discover opportunities as well as employment based in social relationships with previous migrants. There is no doubt that foreign nationals utilise different forms of social capital to achieve different means—the reliance on family at the point of entry to access shelter and employment opportunities whereas they access friendships and networks within the employment circles to access other employment opportunities. The aim of this research is to detail how foreign nationals employ social capital networks as a survival strategy in South African urban townships using Diepsloot, found in the northwest of Johannesburg, as a case study. It is an important study because there is a lack of literature linking social capital as a survival strategy. We focus on social capital because it is a propeller—at least at initial and transition stages of migration—to access other forms of survival strategies. This paper, before all else, derives a conceptual framework that should guide the empirical part of such a research.",book:{id:"6357",slug:"immigration-and-development",title:"Immigration and Development",fullTitle:"Immigration and Development"},signatures:"Nosipho Hlatshwayo and Kambidima Wotela",authors:[{id:"212717",title:"Dr.",name:"Kambidima",middleName:null,surname:"Wotela",slug:"kambidima-wotela",fullName:"Kambidima Wotela"},{id:"212719",title:"Ms.",name:"Nosipho",middleName:null,surname:"Hlatshwayo",slug:"nosipho-hlatshwayo",fullName:"Nosipho Hlatshwayo"}]},{id:"58316",title:"Immigration and Social Inclusion: Possibilities from School and Sports",slug:"immigration-and-social-inclusion-possibilities-from-school-and-sports",totalDownloads:1275,totalCrossrefCites:2,totalDimensionsCites:2,abstract:"Immigration is a manifestation of cultural pluralism that crosses a transversal form, an important part of the western societies, generating consequences in political, social and cultural terms. Likewise, the evidence shows that the educational system attached to sport can be a positive context to promote inclusive processes associated to the immigrant population, due to its high social transcendence and its universal character. On the other hand, sports may act as a tool for social and cultural conflict if they focus on the imposition of a dominant culture or exacerbates the competitive sense. The present chapter has by objective to analyze the possibilities of sports as a tool for the social inclusion of the immigrant population, giving special emphasis to the educational options that were offered by the sport practice in the school context. To do this, it presents an important number of theoretical and empirical backgrounds associated with this topic, which will allow the reader to understand the existing relationship between sport, education and immigration, exposing their possible risks and virtues.",book:{id:"6357",slug:"immigration-and-development",title:"Immigration and Development",fullTitle:"Immigration and Development"},signatures:"Bastian Carter-Thuillier, Victor López-Pastor, Francisco Gallardo-\nFuentes and Juan Carter-Beltran",authors:[{id:"212425",title:"Dr.",name:"Bastian",middleName:null,surname:"Carter-Thuillier",slug:"bastian-carter-thuillier",fullName:"Bastian Carter-Thuillier"},{id:"214391",title:"Dr.",name:"Victor",middleName:null,surname:"Lopez-Pastor",slug:"victor-lopez-pastor",fullName:"Victor Lopez-Pastor"},{id:"214392",title:"Dr.",name:"Francisco",middleName:null,surname:"Gallardo",slug:"francisco-gallardo",fullName:"Francisco Gallardo"},{id:"214393",title:"Dr.",name:"Juan",middleName:null,surname:"Carter-Beltran",slug:"juan-carter-beltran",fullName:"Juan Carter-Beltran"}]},{id:"58881",title:"Refugee Learners’ Experiences of Curriculum Transition in South Africa",slug:"refugee-learners-experiences-of-curriculum-transition-in-south-africa",totalDownloads:1038,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"There is a dearth of scholarship on refugee education particularly the way in which learners navigate a new curriculum in the host country. The purpose of this study is to explore Zimbabwean learners’ experiences of curricula transition at a refugee school in South Africa. The study was performed using a qualitative case study, and its paradigmatic position was interpretive. Bronfenbrenner’s Social Ecological Model was used as a theoretical framework. Ten participants were purposively selected to participate in semi-structured interviews. The study found that refugee learners’ experiences of curricula transition manifest in three categories: content, contextual and conceptual experiences. It is concluded that providing education to refugee learners without giving them the necessary support, which is needed for them to adapt to a new curriculum, is tantamount to setting them up for a failure.",book:{id:"6357",slug:"immigration-and-development",title:"Immigration and Development",fullTitle:"Immigration and Development"},signatures:"Lawrence Meda",authors:[{id:"214446",title:"Dr.",name:"Lawrence",middleName:null,surname:"Meda",slug:"lawrence-meda",fullName:"Lawrence Meda"}]},{id:"57051",title:"Urban Planning in Decentralization and Local Autonomy Era: A Case Study on the Relationship Between Local Government and Civic Group in Development and Budget Planning in Malang City (Indonesia)",slug:"urban-planning-in-decentralization-and-local-autonomy-era-a-case-study-on-the-relationship-between-l",totalDownloads:1182,totalCrossrefCites:1,totalDimensionsCites:0,abstract:"This study aims to explore the relationship between local government and civic groups in the budget planning process of the government of Malang during 2015. Using a grounded theory approach, qualitative methods are applied in this study. The unit of the study is Malang, East Java, Indonesia. Malang is selected as the unit of study because of the many civic groups. The findings of this study show that there exists a relationship between local government and civic groups but that the relationship does not represent the principles of democracy (equality, participation, and justice) in the budget planning. Local government has dominated civic groups in budget planning so that the budget policy does not take public interest into consideration. However, civic groups such as Malang Corruption Watch (MCW) and Education Forum of Society (FMPP) have developed different strategies to develop collective lobbying to direct the development of public awareness through education. These findings contribute to developing budget planning in Malang that establishes a democratic budget policy process that is more responsive to public needs. The local government should realize that public participation is a way to achieve democratic budget process. In this context, elected and appointed officials should provide access for civic groups to be involved in all stages of budget planning. 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