Different types of hepatic trauma patients who were treated at Zliten teaching hospital.
Liver is the second most common solid organ frequently injured by blunt trauma and could be the commonest organ injured by penetrating trauma. The injury can be mild and goes undetected or detected and treated conservatively. It can be severe where the liver wounds can bleed until death. Once the patients with liver injury are resuscitated, the degree of liver injury can be evaluated using ultrasound scan and computed tomography imaging. If the patient is stable, diagnostic peritoneal lavage is very helpful when the imaging facilities are not available. Non-operative treatment of liver trauma has been proven to be valuable in 80% of patients with grade I, II, III and IV (grade I—mild injury; grade II—moderate injury; grade III and IV—severe liver injury). Laparotomy is mandatory if the patient’s condition is unstable. By using the explorative laparotomy technique, the grade of liver injury is assessed, and accordingly the procedure is performed including suturing, ligation of the bleeding vessel, segmental resection, perihepatic packing, and so on. Morbidity and mortality of liver injury can be minimized with early diagnosis and appropriate management.
- liver injury
- non-operative treatment
- grading of liver injury
- perihepatic packing
1. Introduction to surgical anatomy of liver
The liver is situated at the right upper quadrant of the abdomen, extending from the 5th intercostal space at the mid-clavicular line to the 10th costal margin, with a length of about 13 cm which is called the liver span. It weighs 1500 g and is the largest intra-abdominal organ, receiving 1.5 L of blood flow per minute. It is surrounded by a membrane called Glisson’s capsule. It has two lobes—right and left—separated by falciform ligament, two fissures anteriorly where the ligamentum teres is attached, posterior fissure where the ligamentum venosum is attached and the third fissure on the right lobe called porta hepatis where the hepatic triad enters the liver.
1.1. Surfaces of the liver
The liver has diaphragmatic surface which is related to chest cage. Visceral surfaces are related to the following structures: right kidney, right adrenal gland, gall bladder, duodenum and hepatic flexure.
Its surface is attached to the diaphragm by a falciform ligament, right and left triangular ligament and coronary ligament.
The liver is composed of eight segments. Each lobe is composed of four segments. Each segment has its own artery, vein and duct and can be resected separately without interfering with the other segments.
Cantlie line is an imaginary line that goes from the gall bladder fossa to inferior vena cava.
The liver is composed of hepatic plates. Each plate is composed of hepatocytes, sinusoids and Kupffer cells.
1.2. Vascular supply of liver
Hepatic artery comes from the coeliac axis and divides into the right and left. It supplies 25% of blood to the liver, and portal vein supplies 75% of blood to the liver tissues. The portal vein is formed by superior mesenteric vein and splenic vein behind the neck of the pancreas.
1.2.1. Hepatic veins
There are three large hepatic veins, which drain the hepatic parenchyma of the liver lobes into the inferior vena cava.
1.2.2. Nerve supply
Parasympathetic nerve from the right vagus via coelic plexus, left vagus to porta hepatis, and sympathetic nerve along the blood vessels.
Bile production and secretion.
Detoxification of toxins.
Production of heparin, bile pigments.
Storage of glycogen.
Erythropoiesis in infants.
Liver is the second most common abdominal organ that can get injured by blunt trauma [1, 26] and is the most common cause of death in abdominal trauma—100% mortality if untreated or missed from examination. Blunt abdominal trauma is more fatal than penetrating trauma. Before 1993, all liver injuries were treated through surgery. From 1998 onwards, non-operative treatment was introduced as the standard method of treatment for liver trauma with 80% of adult liver trauma treated conservatively and 97% of children also treated non-operatively .
Liver injury can be mild when the trauma affects less than 25% of one lobe, moderate when the trauma affects between 25 and 50% of the lobe, and severe when the trauma affects more than 50% of the lobe.
The liver is prone to trauma for the following reasons:
Fixed position of the liver: The liver is an organ which is huge and fixed at the right upper quadrant of the abdomen.
Liver is an organ with friable parenchyma.
Liver has a thin capsule.
Subcapsular haematoma, laceration, contusion, liver avulsion, bile duct injury, and gall bladder injury. Eighty percent of liver trauma involves segments 6, 7 and 8.
2. Etiology of liver trauma
The liver can be injured commonly by the following:
Blunt trauma commonly due to road traffic accident and can follow fall down from height. Blunt liver trauma is 10 times more fatal than penetrating trauma . Blunt abdominal trauma can sustain up to 1–8% of liver injury. Hepatic trauma forms 15–20% of abdominal trauma and 80% of blunt trauma.
Penetrating trauma caused by a bullet or by stabbing with a sharp instrument.
Iatrogenic trauma is very rare during surgery or during performance of percutaneous transhepatic cholangiography (PTC). Hepatic vein injury can occur during insertion of (transjugular portosystemic shunt (TIPS).
2.1. Diagnosis of liver trauma
2.1.1. A: Clinical picture of liver trauma
Liver injury can be obvious.
Liver injury can be easily predicted.
Liver injury can be difficult to predict.
Liver injury can be positively diagnosed where the following points are clearly established:
The patient is in a state of shock where he or she was involved in a road traffic accident or hit by a bullet at the right upper quadrant of the abdomen.
The patient is with hypotension and pain at the right upper quadrant of the abdomen after a road traffic accident.
Hypotensive patient shows tenderness over the right side of chest with fractured ribs after the trauma.
Hypotensive patient with bruises at the right upper quadrant.
Drop in blood pressure in a patient with road traffic accident and with guarding and tenderness at the right side of the upper abdomen.
Penetrating wound at the right upper quadrant of the abdomen.
Normal blood pressure with right upper abdominal pain with guarding and tenderness at the right upper quadrant
Pain at the right upper quadrant.
Fracture of right lower ribs.
Grading of liver trauma:
Grade I: Subcapsular haematoma less than 10% of the surface area. Laceration less than 1 cm.
Grade II: Haematoma more than 10–50% surface area. Laceration from 1 to 3 cm.
Grade III: Haematoma more than 50%. Laceration more than 3 cm.
Grade IV: Ruptured haematoma and bleeding. Laceration of the liver from 25 to 75% of the lobe.
Grade V: More than 75% of liver laceration, retrohepatic vena cava injury or hepatic vein injuries.
Grade VI: Hepatic avulsion.
2.1.2. B: Investigations
188.8.131.52. Routine investigations
Routine examination includes full blood count, electrolytes, blood sugar, urea, hemoglobin may be normal where the injury is simple, or there may be low hemoglobin indicating blood loss where the injury is severe.
Liver function tests were not done at the admission time and may not be needed if the injury is simple; it could be done if the case showed severe liver trauma. Liver function includes bilirubin, and liver enzymes include glutamic pyruvate transaminase (GPT), glutamic oxaloacetate transainase (GOT) and alkaline phosphatase (ALK) phos.
Blood group is done routinely in all patients with hepatic trauma.
184.108.40.206. Imaging investigations
Ultrasound scan for liver trauma has 99% of specificity and 88% of sensitivity [19, 20, 21]. Fast ultrasound replaced peritoneal lavage. Looking to Morrison space if there is fluid in the space indicating bleeding. The use of contrast with ultrasound scan is more beneficial in liver trauma.
2.2. Treatment of liver trauma
Table 1 shows the number and types of liver trauma treated using different treatments in a busy general hospital.
|Mode||Number of patients||Lobe||Grade||Procedure||Outcome|
|RTA||94||Left lobe and right lobe||Range from grade I to VI||1. Conservative treatment: 35 cases
2. Diagnostic laparoscopy: 12 suturing and insertion of drain
3. Laparotomy: 47
3-A. Repair of liver wounds: 30
3-B. Packing: 14 perihepatic packing
3-C. Resection: Three had segmental liver resection
|Grade I and II had few patients, and most were grade III, IV||All underwent laparotomy, debridement, repair, omental packing, eight patients had perihepatic packing||18 died|
|Stab||13||Left lobe and right lobe||I and II||Conservative management||Nil|
Eighty percent of adults with liver trauma were treated conservatively, and 97% of those were children who were treated conservatively.
Healing of liver trauma: The liver has good capacity of healing once it is traumatized.
Mild liver trauma: Less than 25% of lobe damage takes 3 months to heal.
Moderate liver trauma: Between 25 and 50% takes 6 months to heal.
Severe injury: Liver injury, which encompasses more than 50% of lobe injured, takes 9 months to heal or more.
Patients with liver trauma blunt or penetrating, mild or severe once diagnosed or suspected should undergo resuscitation as usual traumatized patients, which include caring of respiration, putting good venous access for the fluids, treating emergency killing conditions like tension pneumothorax, fixing urinary catheter to know the output. After patient resuscitation,the grading of liver trauma is evaluated clinically and by imaging and the mode of treatment is planned which will include either [8, 9, 10].
Interventional radiology treatment of liver trauma.
2.2.1. Conservative treatment of liver trauma
Conservative treatment includes the following:
Full assessment of patients.
Full assessment of the grade of liver injury by ultrasound and CT scan.
Correction of blood loss by giving blood.
Daily monitoring of patient.
Discharge of patient once he is fully stable and active.
Post-discharge follow-up by clinical assessment and imaging.
2.2.2. Non-operative treatment of liver injury
Non operative management was firstly conducted in children than started in adult, it is not indicated in elderly patients, choosing of the patients for non-operative management (NOM) depends on clinical condition of the patients and associated injury, less on grade of the liver of injury [2, 16].
2.2.3. Advantages of NOM
Less hospital stay.
Avoidance of unnecessary laparotomy.
An unstable patient can be defined as follows:
Systolic blood pressure less than 90 mmhg.
Pulse rate more than 120 beats per minute.
Altered consciousness level.
Cold clammy skin.
About 80% of blunt liver trauma can be treated conservatively, provided the patient is haemodynamically stable. It can be utilized even in grade IV.
Non-operative treatment can be performed for the following reasons:
Patients who are haemodynamically stable with no signs of peritonism.
Operative management should be available when needed.
Imaging facilities should be available to follow the treatments, which can lead to 100% success rate.
Liver trauma at Zliten University Hospital over a period of 9 years from 2009 to 2017—Patients: 231, deaths: 31, patients who underwent conservative treatment: 48 (Table 1).
Most of our patients with liver trauma during war, the time where the weapon is scattered in many regions of the country; none of our patients with hepatic trauma having had gun shot wounds left for conservative treatment, and all patients underwent surgery. This number affected our conservative management in hepatic trauma. Our rate of conservative treatment for patients with hepatic trauma was approximately 50%.
2.2.4. Complications of NOM
Complications of NOM can be diagnosed by clinical examination including blood tests, ultrasound scan and CT scan. Complications may reach up to 7% in grade III and V.
Bile collection may reach up to 20%—biliary peritonitis. Haemobilia: Bile leak is treated with endoscopic retrograde cholangiopancreatography most of our patients with liver trauma were during war. If fluid collection is significant, it can be drained percutaneously, laparoscopically or open surgery. Figure 2 shows the CT of a child with hepatic trauma managed conservatively with the development of bilioma). Figure 3 shows bilioma collection that was treated by laparotomy.
Nagano-classified bile leak:
Type A: Minor bile leak, small radicle from the liver surface—resolved spontaneously.
Type B: Bile leak from a major duct on the liver surface not tied.
Type C: Injury of duct branch from the main duct at the hilum.
Type D: Main bile duct transected.
Infection and abscess formation may reach 7% and can be treated conservatively when clinical manifestation is significant.
Liver necrosis can be diagnosed clinically with raised liver enzymes, coagulation abnormalities or bile leak.
Bleeding: Hepatic artery pseudo-aneurysm accounts to about 1–2% and can be either extrahepatic or intrahepatic—more cases of extrahepatic nature. Liver compartment syndrome due to compression of the liver by huge subcapsular haematoma may result in liver failure.
2.2.5. Surgical treatment of liver injury
Surgery is indicated in a patient who is unstable.
Simple suturing of liver tear.
Debridment of unhealthy liver tissue and suturing.
Resection of severely damaged segment.
Liver lobectomy or hepatectomy for severely damaged lobe.
Perihepatic packing for uncontrolled bleeding in unstable patients.
Arterial embolization which can be performed as the first option in patients who are planned for non-operative treatment or for those patient who developed bleeding after surgery .
Damage control is of three phases:
Phase I: Control of bleeding, closure of the abdomen.
Phase II: Intensive care unit resuscitation and overcome on acidosis, hypothermia, hyper-coagulability.
Phase III: Re-exploration of the abdomen.
In 1983, Stone et al. proposed damage control for trauma patient [6, 14, 22, 23, 24]. Once patient had severe liver trauma, where the condition of the patient is deteriorating during surgery and the bleeding is continuous from the damaged liver, either the damage at the posterior aspect or whole of the liver, damage control is utilized in the form of packing the liver with abdominal gauze pack which are wrapped around the liver [4, 5, 6]. This technique is useful in the management of controlling the bleeding that occurs during surgery and liver resection. Packing is also useful to avoid the three killers of the patient during surgery which includes acidosis, hypercoagulability and hypothermia, which can cause cardiac arrest. To avoid the occurrence of these bad incidents, we should change to damage control. Usually six packs are placed around the liver to stop the bleeding. The abdomen left either open or closed depending on the patient’s condition with the use of Bogota bag. Packing the liver with gauze packs can be complicated when patients need to go through full resuscitation in the ICU. For the correction of the three killers including acidosis, hyperthermia, hypercoagulability, usually it needs time for our patients 48–72 h to control sepsis with the use of antibiotics.
The complication of perihepatic packing includes the following:
Respiratory embarrassment due to compression on the right dome of the diaphragm.
Abdominal sepsis if the packs were left longer than 3 days.
Other surgical procedure for liver trauma include
Laparoscopic assessment of liver trauma and suturing of liver tear .
Liver transplantation for severely damaged liver is difficult to perform because of availability of the liver and the experienced team.
Liver exclusion and extracorporeal circulation is seldom done for severe liver trauma.
Controlling of liver bleeding: Bleeding from the liver is controlled by the following procedures
Hepatorrhaphy and control of the arterial bleeding.
Use of omental pack and mattress sutures.
Selective hepatic artery ligation may control the bleeding.
Non-anatomical resection, anatomical resection, venovenous shunt, atriocaval shunts.
Mortality of blunt trauma is 27% and of penetrating trauma is 11%.
Overall, mortality of liver trauma is 10%, Grade III and IV mortality is 10% and V and VI are 75%.
There are many haemostatic materials used for liver trauma are very helpful for controlling the bleeding, which includes the following:
Koyama T, Skattum J, Engelsen P, Eken T, Gaarder C, Naess PA. Surgical intervention for paediatric liver injuries is almost history–A 12-year cohort from a major Scandinavian trauma centre. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine. 2016; 24:139
Li M, Yu WK, Wang XB, Ji W, Li JS. Non-operative management of isolated liver trauma. Hepatobiliary & Pancreatic Diseases International. 2014 Oct; 13(5):545-550
Letoublon C, Amariutei A, Taton N, Lacaze L, Abba J, Risse O, Arvieux C. Management of blunt hepatic trauma. Journal of Visceral Surgery. 2016 Aug; 153(4 Suppl):33-43. DOI: 10.1016/j.jviscsurg.2016.07.005
Ng N, McLean SF, Ghaleb MR, Tyroch A. Hepatic “BOLSA” a novel method of perihepatic wrapping for hepatic hemorrhage “BOLSA”. International Journal of Surgery Case Reports. 2015; 13:99-102. DOI: 10.1016/j.ijscr.2015.06.007
Stassen NA, Bhullar I, Cheng JD, Crandall M, Friese R, Guillamondegui O, Jawa R, Maung A, Rohs TJ Jr, Sangosanya A, Schuster K, Seamon M, Tchorz KM, Zarzuar BL, Kerwin A. Nonoperative management of blunt hepatic injury: An Eastern Association for the Surgery of Trauma practice management guideline. Journal of Trauma and Acute Care Surgery; 73(5)
Lin BC, Fang JF, Chen RJ, Wong YC, Hsu YP. Surgical management and outcome of blunt major liver injuries: Experience of damage controllaparotomy with perihepatic packing in one trauma centre. Injury. 2014 Jan; 45(1):122-127. DOI: 10.1016/j.injury.2013.08.022
Schnüriger B, Inderbitzin D, Schafer M, Kickuth R, Exadaktylos A, Candinas D. Concomitant injuries are an important determinant of outcome of high-grade blunt hepatic trauma. The British Journal of Surgery. 2009 Jan; 96(1):104-110. DOI: 10.1002/bjs.6439
Girgin S, Gedik E, Taçyildiz IH. Evaluation of surgical methods in patients with blunt liver trauma. Ulusal Travma ve Acil Cerrahi Dergisi. 2006 Jan; 12(1):35-42
Gür S, Orsel A, Atahan K, Hökmez A, Tarcan E. Surgical treatment of liver trauma (analysis of 244 patients). Hepato-Gastroenterology. 2003 Nov-Dec; 50(54):2109-2111
Terrinoni V, Catroppo JF, Caramanico L, Cosimati A, Cosimati P, Bellini N, Abate O, Rengo M. The diagnostic-therapeutic picture in liver injuries: A review of the literature and clinical cases. Il Giornale di Chirurgia. 1995 Jan-Feb; 16(1-2):48-54
Buci S, Torba M, Gjata A, Kajo I, Bushi G, Kagjini K. The rate of success of the conservative management of liver trauma in a developing country. World Journal of Emergency Surgery. 2017; 12:24
Lim KH, Chung BS, Kim JY, Kim SS. Laparoscopic surgery in abdominal trauma: A single center review of a 7-year experience. World Journal of Emergency Surgery. 2015; 10:16
Giss SR, Dobrilovic N, Brown RL, Garcia VF. Complications of nonoperative management of pediatric blunt hepatic injury: Diagnosis, management, and outcomes. The Journal of Trauma. 2006 Aug; 61(2)
Kobayashi T, Kubota M, Arai Y, Ohyama T, Yokota N, Miura K, Ishikawa H, Soma D, Takizawa K, Sakata J, Nagahashi M, Kameyama H, Wakai T. Staged laparotomies based on the damage control principle to treat hemodynamically unstable grade IV blunt hepatic injury in an eight-year-old girl. Surgical Case Reports. 2016 Dec; 2:134
Moreno P, Von Allmen M, Haltmeier T, Candinas D, Schnüriger B. Long-term follow-up after non-operative management of blunt splenic and liver injuries: A questionnaire-based survey. World Journal of Surgery. 2017 Nov 14. DOI: 10.1007/s00268-017-4336-5
Perumean JC, Martinez M, Neal R, Lee J, Olajire-Aro T, Imran JB, Williams BH, Phelan HA. Low-grade blunt hepatic injury and benefits of intensive care unit monitoring. American Journal of Surgery. 2017 Dec; 214(6):1188-1192. DOI: 10.1016/j.amjsurg.2017.09.003
Melloul E, Denys A, Demartines N. Management of severe blunt hepatic injury in the era of computed tomography and transarterial embolization: A systematic review and critical appraisal of the literature. Journal of Trauma and Acute Care Surgery. 2015 Sep; 79(3):468-474. DOI: 10.1097/TA.0000000000000724
Cirocchi R, Trastulli S, Pressi E, Farinella E, Avenia S, Morales Uribe CH, Botero AM, Barrera LM. Non-operative management versus operative management in high-grade blunt hepatic injury. Cochrane Database of Systematic Reviews. 2015 Aug 24; 8:CD010989. DOI: 10.1002/14651858.CD010989
Stengel D, Rademacher G, Ekkernkamp A, Güthoff C, Mutze S. Emergency ultrasound-based algorithms for diagnosing blunt abdominal trauma. Cochrane Database of Systematic Reviews. 2015 Sep 14; 9:CD004446. DOI: 10.1002/14651858.CD004446.pub4
Quinn AC, Sinert R. What is the utility of the Focused Assessment with Sonography in Trauma (FAST) exam in penetrating torso trauma? Injury. DOI: injury.2010.07.249
Kaptanoglu L, Kurt N, Sikar HE. Current approach to liver traumas. International Journal of Surgery. 2017 Mar; 39:255-259. DOI: 10.1016/j.ijsu.2017.02.015
Recordare A, Bruno GT, Callegari P, Guarise A, Bassi N. Bleeding control by radiofrequency in penetrating trauma of the liver. G Chir. 2011 Apr; 32(4):203-5.25
Krige JE, Bornman PC, Terblanche J. Therapeutic perihepatic packing in complex liver trauma. The British Journal of Surgery. 1992 Jan; 79(1):43-46
Reed RL 2nd, Merrell RC, Meyers WC, Fischer RP. Continuing evolution in the approach to severe liver trauma. Annals of Surgery. 1992 Nov; 216(5):524-538
van As Alastair AB, Milla JW. Management of paediatric liver trauma. Pediatric Surgery International. April 2017; 33(4):445-453
Kalil M, Amaral IM. Epidemiological evaluation of hepatic trauma victims undergoing surgery. Revista do Colégio Brasileiro de Cirurgiões. 2016 Feb; 43(1):22-27
Safi F, Weiner S, Poch B, Schwarz A, Beger HG. Surgical management of liver rupture. Der Chirurg. 1999 Mar; 70(3):253-258
John TG, Greig JD, Johnstone AJ, Garden OJ. Liver trauma: A 10-year experience. The British Journal of Surgery. 1992 Dec; 79(12):1352-1356
Vatanaprasan T. Operative Treatment of hepatic trauma in Vachira Phuket hospital. Journal of the Medical Association of Thailand. 2005 Mar; 88(3):318-328