\\n\\n
Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\\n\\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\\n"}]',published:!0,mainMedia:{caption:"Highly Cited",originalUrl:"/media/original/117"}},components:[{type:"htmlEditorComponent",content:'IntechOpen is proud to announce that 191 of our authors have made the Clarivate™ Highly Cited Researchers List for 2020, ranking them among the top 1% most-cited.
\n\nThroughout the years, the list has named a total of 261 IntechOpen authors as Highly Cited. Of those researchers, 69 have been featured on the list multiple times.
\n\n\n\nReleased this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\n\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\n'}],latestNews:[{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"},{slug:"intechopen-identified-as-one-of-the-most-significant-contributor-to-oa-book-growth-in-doab-20210809",title:"IntechOpen Identified as One of the Most Significant Contributors to OA Book Growth in DOAB"}]},book:{item:{type:"book",id:"5831",leadTitle:null,fullTitle:"Clostridium Difficile - A Comprehensive Overview",title:"Clostridium Difficile",subtitle:"A Comprehensive Overview",reviewType:"peer-reviewed",abstract:"Clostridium difficile bacteria could be found everywhere around us: in the air, water, and soil and in the feces of humans and animals. You can easily become infected with C. difficile if you touch contaminated clothing, sheets, or other objects and then touch your mouth. Many people have the bacteria in their intestines and never have any symptoms. Still, it can cause symptoms ranging from diarrhea to life-threatening inflammation of the colon. The chance of developing a C. difficile infection increases with the usage of high doses of antibiotics over a prolonged period; thus, it is most often spread in the healthcare facilities between workers, patients, and residents. Each year in the United States, almost a half million people get sick from C. difficile, and approximately 29,000 patients died within 30 days of its initial diagnosis. Nowadays, C. difficile infections have become more frequent, severe, and difficult to treat. Therefore, the early diagnosis and the suitable treatment have become a real demand. In this book, we present the experience of worldwide specialists on the diagnosis and the treatment of C. difficile infections along with its lights and shadows.",isbn:"978-953-51-3428-2",printIsbn:"978-953-51-3427-5",pdfIsbn:"978-953-51-4643-8",doi:"10.5772/65578",price:119,priceEur:129,priceUsd:155,slug:"clostridium-difficile-a-comprehensive-overview",numberOfPages:160,isOpenForSubmission:!1,isInWos:1,isInBkci:!1,hash:"fabbec5ed99960d2fb904f16790e8b97",bookSignature:"Shymaa Enany",publishedDate:"September 27th 2017",coverURL:"https://cdn.intechopen.com/books/images_new/5831.jpg",numberOfDownloads:10550,numberOfWosCitations:2,numberOfCrossrefCitations:3,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:4,numberOfDimensionsCitationsByBook:0,hasAltmetrics:1,numberOfTotalCitations:9,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"October 10th 2016",dateEndSecondStepPublish:"October 31st 2016",dateEndThirdStepPublish:"January 27th 2017",dateEndFourthStepPublish:"April 27th 2017",dateEndFifthStepPublish:"June 26th 2017",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"81926",title:"Dr.",name:"Shymaa",middleName:null,surname:"Enany",slug:"shymaa-enany",fullName:"Shymaa Enany",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRqB9QAK/Profile_Picture_1626163237970",biography:"Dr. Shymaa Enany is an associate professor of Microbiology at Suez Canal University, Egypt. She received her PhD from School of Medical Sciences, Niigata University, Japan, and spent her postdoc in USA and Japan. She was the first Arab scientist applying bacterial proteomic techniques helping in revealing good markers for microbes spreading in community. She received many awards for her scientific contributions. Recently, she awarded the most prestigious award in Egypt: the state encouragement prize for women in the field of health and pharmaceutical sciences, 2019. Also, she was awarded The World Academy of Sciences (TWAS) Young Arab Scientist Prize 2018 for Scientific Achievement in Medical Sciences. She was selected as a member of Egyptian Young Academy of Science, an evaluator on Academy of Scientific Research and Technology, a reviewer in International Exhibition of Innovation, and an affiliate of The World Academy of Sciences. Dr. Shymaa is also a part of the scientific committee of World Forum for Women in Science, a selected young leader in STS and WSF, a member in the global Open Science Group, and a collaborator in Global Burden of Disease. On Microbiology National Committee, she is working for achieving sustainable development goals for a better future. She was appointed an Egyptian ambassador in Next Einstein Forum (NEF), which showcases the global contribution and potential of scientists from Africa, enabling Africa to get onto the global scientific stage, and she is a selected member in COVID-19 Diagnostics group in Africa, as well as the co-chair of the COVID-19 Clinical Research Coalition platform (Immunology, Virology and Diagnostics Working Group) in low- and middle-income countries. Latterly, she is selected as an African science leadership program fellow.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"2",totalChapterViews:"0",totalEditedBooks:"5",institution:{name:"Suez Canal University",institutionURL:null,country:{name:"Egypt"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"906",title:"Bacteriology",slug:"pure-microbiology-bacteriology"}],chapters:[{id:"56444",title:"Introductory Chapter: Clostridium difficile Infection Overview",doi:"10.5772/intechopen.69983",slug:"introductory-chapter-clostridium-difficile-infection-overview",totalDownloads:1364,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Shymaa Enany",downloadPdfUrl:"/chapter/pdf-download/56444",previewPdfUrl:"/chapter/pdf-preview/56444",authors:[{id:"81926",title:"Dr.",name:"Shymaa",surname:"Enany",slug:"shymaa-enany",fullName:"Shymaa Enany"}],corrections:null},{id:"55751",title:"Overview of Clostridium difficile Infection: Life Cycle, Epidemiology, Antimicrobial Resistance and Treatment",doi:"10.5772/intechopen.69053",slug:"overview-of-clostridium-difficile-infection-life-cycle-epidemiology-antimicrobial-resistance-and-tre",totalDownloads:2719,totalCrossrefCites:2,totalDimensionsCites:3,hasAltmetrics:1,abstract:"The use of antimicrobial agents and acquired resistances explains in part the emergence and spreading of epidemic strains of Clostridium difficile. Continued use of antimicrobial therapy still represents an acute danger in triggering the emergence and spreading of new resistant and multiresistant strains including against first-line antibiotics. We examine the pathway of peptidoglycan synthesis in this organism and associated resistances, as well as resistance to other classes of antibiotics. The life cycle of C. difficile involves growth, spore formation and germination. Spores endow the organism with a formidable capacity of persistence in the environment and in the host, resistance, dissemination and infectious potential. Highly resistant spores produced by antibiotic-resistant/multiresistant strains may be one of the most serious challenges we face in what concerns the containment of C. difficile. Finally, we review recent developments in the treatment and prevention of C. difficile infection.",signatures:"Joana Isidro, Aristides L. Mendes, Mónica Serrano, Adriano O.\nHenriques and Mónica Oleastro",downloadPdfUrl:"/chapter/pdf-download/55751",previewPdfUrl:"/chapter/pdf-preview/55751",authors:[{id:"164933",title:"Prof.",name:"Mónica Alexandra",surname:"Sousa Oleastro",slug:"monica-alexandra-sousa-oleastro",fullName:"Mónica Alexandra Sousa Oleastro"},{id:"200015",title:"Dr.",name:"Joana",surname:"Isidro",slug:"joana-isidro",fullName:"Joana Isidro"},{id:"200016",title:"MSc.",name:"Aristides",surname:"Mendes",slug:"aristides-mendes",fullName:"Aristides Mendes"},{id:"200017",title:"Prof.",name:"Mónica",surname:"Serrano",slug:"monica-serrano",fullName:"Mónica Serrano"},{id:"200019",title:"Prof.",name:"Adriano",surname:"Henriques",slug:"adriano-henriques",fullName:"Adriano Henriques"}],corrections:null},{id:"54496",title:"Clostridium difficile Infection: Pathogenesis, Diagnosis and Treatment",doi:"10.5772/67754",slug:"clostridium-difficile-infection-pathogenesis-diagnosis-and-treatment",totalDownloads:1703,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:1,abstract:"Clostridium difficile is a Gram-positive bacterium with the capacity of spore generation. The C. difficile infections, related to antibiotic treatment, have increased in number and severity during the last few years; increasing the health problems caused by this bacterium. One of the most important problems of the C. difficile infection is the recurrence. Due to all of these facts, researchers have been searching for new treatments such as faecal microbiota transplantation or bacteriocins development.",signatures:"Laura Fernández-García, Lucia Blasco, María López and Maria\nTomás",downloadPdfUrl:"/chapter/pdf-download/54496",previewPdfUrl:"/chapter/pdf-preview/54496",authors:[{id:"198586",title:"Dr.",name:"Maria",surname:"Tomas",slug:"maria-tomas",fullName:"Maria Tomas"},{id:"204982",title:"Ms.",name:"Laura",surname:"Fernandez-García",slug:"laura-fernandez-garcia",fullName:"Laura Fernandez-García"},{id:"204983",title:"Ms.",name:"Lucia",surname:"Blasco",slug:"lucia-blasco",fullName:"Lucia Blasco"},{id:"204984",title:"Dr.",name:"Maria",surname:"Lopez",slug:"maria-lopez",fullName:"Maria Lopez"}],corrections:null},{id:"55253",title:"Clostridium difficile Infection Diagnosis by Biological Molecular Methods",doi:"10.5772/intechopen.68692",slug:"clostridium-difficile-infection-diagnosis-by-biological-molecular-methods",totalDownloads:1956,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"In the past 15 years, the incidence of Clostridium difficile infection has emerged especially because of the new highly virulent strains. The classical diagnosis methods used to diagnose C. difficile infection take time and the enzyme immunoassay (EIA) test has demonstrated the lack of sensitivity. Even though new modern molecular methods have become available, the diagnosis of C. difficile in patients or healthy carriers remains a big challenge for both clinicians and laboratory staff. In the present chapter, we will list the main genotyping methods, stressing their advantages and disadvantages, as well. A brief presentation of the most useful kit (principle, sensitivity, specificity, benefits and disadvantages) to assess the impact of molecular methods in comparison with classical methods will offer support for future research in the present context of an increasing prevalence of C. difficile infection that represents worldwide, a real public health problem. To improve the patients’ quality of life, to limit hospital transmission, and to save money, we have tried to identify the best diagnosis algorithm as tool in C. difficile diagnosis and surveillance. This algorithm may differ depending on the capacities of the laboratories and on the socioeconomic level of the countries in question.",signatures:"Luminiţa Smaranda Iancu, Andrei Florin Cârlan and Ramona\nGabriela Ursu",downloadPdfUrl:"/chapter/pdf-download/55253",previewPdfUrl:"/chapter/pdf-preview/55253",authors:[{id:"197809",title:"Prof.",name:"Luminiţa Smaranda",surname:"Iancu",slug:"luminita-smaranda-iancu",fullName:"Luminiţa Smaranda Iancu"},{id:"205531",title:"Dr.",name:"Andrei",surname:"Cârlan",slug:"andrei-carlan",fullName:"Andrei Cârlan"},{id:"205532",title:"Dr.",name:"Ramona Gabriela",surname:"Ursu",slug:"ramona-gabriela-ursu",fullName:"Ramona Gabriela Ursu"}],corrections:null},{id:"54736",title:"Assays for Measuring C. difficile Toxin Activity and Inhibition in Mammalian Cells",doi:"10.5772/68127",slug:"assays-for-measuring-c-difficile-toxin-activity-and-inhibition-in-mammalian-cells",totalDownloads:1341,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Clostridium difficile infections (CDIs) are the leading cause of hospital-acquired infectious diarrhea. The symptoms of CDI are caused by two exotoxins, TcdA and TcdB, which are structurally and functionally highly homologous. Both toxins bind to specific receptors on mammalian cells, are internalized through endocytosis, translocate to the cytoplasm, and inactivate Rho-type GTPases via covalent glucosylation. This leads to downstream events that include morphological changes and disruption of epithelial tight junctions, release of pro-inflammatory mediators, and cell death. Assays used to assess the effects of toxins on cells have historically relied on evaluation of cell rounding or quantitation of ATP levels to estimate cell death—assays which can be qualitative and variable. In this chapter, several assays are described that robustly and quantitatively measure early and late toxin-dependent events in cells, including (i) toxin binding, (ii) Rac1 glucosylation, (iii) changes in cellular morphology (measured as dynamic mass redistribution), (iv) loss of epithelial integrity (measured as transepithelial electrical resistance), and (v) cell death (measured as total cellular protein using a colorimetric assay). The assays were validated using the highly specific monoclonal antitoxin antibodies, actoxumab and bezlotoxumab, which neutralize TcdA and TcdB, respectively.",signatures:"Mary Ann Cox, Lorraine D. Hernandez, Pulkit Gupta, Zuo Zhang,\nFred Racine and Alex G. Therien",downloadPdfUrl:"/chapter/pdf-download/54736",previewPdfUrl:"/chapter/pdf-preview/54736",authors:[{id:"171428",title:null,name:"Alex",surname:"Therien",slug:"alex-therien",fullName:"Alex Therien"}],corrections:null},{id:"55694",title:"Clostridium difficile in the ICU",doi:"10.5772/intechopen.69212",slug:"clostridium-difficile-in-the-icu",totalDownloads:1467,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Clostridium difficile has become an increasingly common infectious agent in the healthcare setting. It is generally associated with antibiotic use and causes diarrhea as well as other complications such as pseudomembranous colitis (PMC) and toxic megacolon. This organism poses a serious threat to patients in the intensive care unit (ICU) as it increases hospital length of stay, morbidity, and mortality. Recurrence rates are typically higher in the ICU population as those patients usually have immunocompromised systems, more exposure to antibiotics and proton pump inhibitors, loss of normal nutritional balance, and alterations in their colonic flora. Emergence of more virulent and pathogenic strains has made combating the infection even more difficult. Newer therapies, chemotherapeutic agents, and vaccinations are on the horizon. However, the most effective treatments to date are ceasing the inciting agent, reduction in the use of proton pump inhibitors, and prevention of the disease. In this chapter, we will explore the risk factors, diagnosis, treatment, and prevention of C. difficile infections (CDI) in the ICU.",signatures:"William C. Sherman, Chris Lewis, Jong O. Lee and David N. Herndon",downloadPdfUrl:"/chapter/pdf-download/55694",previewPdfUrl:"/chapter/pdf-preview/55694",authors:[{id:"203959",title:"Dr.",name:"William",surname:"Sherman",slug:"william-sherman",fullName:"William Sherman"},{id:"203979",title:"Dr.",name:"Christopher",surname:"Lewis",slug:"christopher-lewis",fullName:"Christopher Lewis"},{id:"203980",title:"Dr.",name:"Jong",surname:"Lee",slug:"jong-lee",fullName:"Jong Lee"},{id:"203981",title:"Dr.",name:"David",surname:"Herndon",slug:"david-herndon",fullName:"David Herndon"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"5471",title:"Frontiers in Staphylococcus aureus",subtitle:null,isOpenForSubmission:!1,hash:"514afc8c2d4eb28ddca22c032ad96d9e",slug:"frontiers-in-i-staphylococcus-aureus-i-",bookSignature:"Shymaa Enany and Laura E. Crotty Alexander",coverURL:"https://cdn.intechopen.com/books/images_new/5471.jpg",editedByType:"Edited by",editors:[{id:"81926",title:"Dr.",name:"Shymaa",surname:"Enany",slug:"shymaa-enany",fullName:"Shymaa Enany"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6045",title:"The Rise of Virulence and Antibiotic Resistance in Staphylococcus aureus",subtitle:null,isOpenForSubmission:!1,hash:"4f24bfdcb5cd606846da63b96000bed2",slug:"the-rise-of-virulence-and-antibiotic-resistance-in-staphylococcus-aureus",bookSignature:"Shymaa Enany and Laura E. Crotty Alexander",coverURL:"https://cdn.intechopen.com/books/images_new/6045.jpg",editedByType:"Edited by",editors:[{id:"81926",title:"Dr.",name:"Shymaa",surname:"Enany",slug:"shymaa-enany",fullName:"Shymaa Enany"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6425",title:"Probiotics",subtitle:"Current Knowledge and Future Prospects",isOpenForSubmission:!1,hash:"129bd046ff0fb4db6584e5afeebe98fa",slug:"probiotics-current-knowledge-and-future-prospects",bookSignature:"Shymaa Enany",coverURL:"https://cdn.intechopen.com/books/images_new/6425.jpg",editedByType:"Edited by",editors:[{id:"81926",title:"Dr.",name:"Shymaa",surname:"Enany",slug:"shymaa-enany",fullName:"Shymaa Enany"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6685",title:"Basic Biology and Applications of Actinobacteria",subtitle:null,isOpenForSubmission:!1,hash:"301e66d4a6b29d4326c39ff2922ec420",slug:"basic-biology-and-applications-of-actinobacteria",bookSignature:"Shymaa Enany",coverURL:"https://cdn.intechopen.com/books/images_new/6685.jpg",editedByType:"Edited by",editors:[{id:"81926",title:"Dr.",name:"Shymaa",surname:"Enany",slug:"shymaa-enany",fullName:"Shymaa Enany"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10442",title:"Cyanobacteria",subtitle:"Recent Advances in Taxonomy and Applications",isOpenForSubmission:!1,hash:"2fec78743d3f973c80881957ce3e6d79",slug:"cyanobacteria-recent-advances-in-taxonomy-and-applications",bookSignature:"Wael N. Hozzein",coverURL:"https://cdn.intechopen.com/books/images_new/10442.jpg",editedByType:"Edited by",editors:[{id:"189233",title:"Prof.",name:"Wael N.",surname:"Hozzein",slug:"wael-n.-hozzein",fullName:"Wael N. Hozzein"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9665",title:"Pseudomonas aeruginosa",subtitle:"Biofilm Formation, Infections and Treatments",isOpenForSubmission:!1,hash:"00e9f0f41cf8cd97ff33fac3bcea14cb",slug:"pseudomonas-aeruginosa-biofilm-formation-infections-and-treatments",bookSignature:"Theerthankar Das",coverURL:"https://cdn.intechopen.com/books/images_new/9665.jpg",editedByType:"Edited by",editors:[{id:"179493",title:"Dr.",name:"Theerthankar",surname:"Das",slug:"theerthankar-das",fullName:"Theerthankar Das"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],ofsBooks:[]},correction:{item:{id:"67322",slug:"corrigendum-to-sexual-dysfunction-in-patients-with-systemic-sclerosis",title:"Corrigendum to: Sexual Dysfunction in Patients with Systemic Sclerosis",doi:null,correctionPDFUrl:"https://cdn.intechopen.com/pdfs/67322.pdf",downloadPdfUrl:"/chapter/pdf-download/67322",previewPdfUrl:"/chapter/pdf-preview/67322",totalDownloads:null,totalCrossrefCites:null,bibtexUrl:"/chapter/bibtex/67322",risUrl:"/chapter/ris/67322",chapter:{id:"66966",slug:"sexual-dysfunction-in-patients-with-systemic-sclerosis",signatures:"Barbora Heřmánková",dateSubmitted:"July 16th 2018",dateReviewed:"April 5th 2019",datePrePublished:"May 3rd 2019",datePublished:"September 18th 2019",book:{id:"8269",title:"New Insights into Systemic Sclerosis",subtitle:null,fullTitle:"New Insights into Systemic Sclerosis",slug:"new-insights-into-systemic-sclerosis",publishedDate:"September 18th 2019",bookSignature:"Michal Tomcik",coverURL:"https://cdn.intechopen.com/books/images_new/8269.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"193284",title:"Dr.",name:"Michal",middleName:null,surname:"Tomcik",slug:"michal-tomcik",fullName:"Michal Tomcik"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:null}},chapter:{id:"66966",slug:"sexual-dysfunction-in-patients-with-systemic-sclerosis",signatures:"Barbora Heřmánková",dateSubmitted:"July 16th 2018",dateReviewed:"April 5th 2019",datePrePublished:"May 3rd 2019",datePublished:"September 18th 2019",book:{id:"8269",title:"New Insights into Systemic Sclerosis",subtitle:null,fullTitle:"New Insights into Systemic Sclerosis",slug:"new-insights-into-systemic-sclerosis",publishedDate:"September 18th 2019",bookSignature:"Michal Tomcik",coverURL:"https://cdn.intechopen.com/books/images_new/8269.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"193284",title:"Dr.",name:"Michal",middleName:null,surname:"Tomcik",slug:"michal-tomcik",fullName:"Michal Tomcik"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:null},book:{id:"8269",title:"New Insights into Systemic Sclerosis",subtitle:null,fullTitle:"New Insights into Systemic Sclerosis",slug:"new-insights-into-systemic-sclerosis",publishedDate:"September 18th 2019",bookSignature:"Michal Tomcik",coverURL:"https://cdn.intechopen.com/books/images_new/8269.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"193284",title:"Dr.",name:"Michal",middleName:null,surname:"Tomcik",slug:"michal-tomcik",fullName:"Michal Tomcik"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}}},ofsBook:{item:{type:"book",id:"11576",leadTitle:null,title:"Malaria - Recent Advances, and New Perspectives",subtitle:null,reviewType:"peer-reviewed",abstract:"\r\n\tMalaria is an acute febrile illness caused by Plasmodium parasites, which are spread to people through the bites of infected female Anopheles mosquitoes. It’s the second commonest infectious disease worldwide (following hepatitis B). Despite being potentially preventable and curable, in 2020 there were an estimated 241 million cases; the estimated number of deaths being 627,000. Nearly half of the world's population is at risk of malaria. However, some population groups are at considerably higher risk of contracting malaria and developing the severe disease: children, pregnant women, and patients with low immunity. Noteworthy, 95% of malaria cases and 96% of malaria deaths occur in African Countries, with 80% of all deaths being in children under 5. Recent advancements include more accurate vectors control, chemotherapies, and possibly vaccine development. In this book, the current and most advanced knowledge about malaria is discussed, by focusing on pathobiology, diagnosis, clinical features, and management.
",isbn:"978-1-80356-792-1",printIsbn:"978-1-80356-791-4",pdfIsbn:"978-1-80356-793-8",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,hash:"5a01644fb0b4ce24c2f947913d154abe",bookSignature:"Prof. Pier Paolo Piccaluga",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11576.jpg",keywords:"Histopathology, Etiology, Pathogenesis, Cytology, Molecular Diagnostics, Prophylaxis, Vaccine, Antimalarial Drug Therapy, Antimalarial Drug Resistance, New Drugs, Fever, Differential Diagnosis",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"March 29th 2022",dateEndSecondStepPublish:"April 26th 2022",dateEndThirdStepPublish:"June 25th 2022",dateEndFourthStepPublish:"September 13th 2022",dateEndFifthStepPublish:"November 12th 2022",remainingDaysToSecondStep:"19 days",secondStepPassed:!0,currentStepOfPublishingProcess:3,editedByType:null,kuFlag:!1,biosketch:"Dr. Piccaluga's high h-index of 49 is a strong indicator of his high merit as a researcher working in the field of oncology and hematology. He has three patents on molecular diagnostic tools for hematological cancers. He is involved in several clinical trials as a coordinator or sub-investigator. Winner of several prizes for study and research.",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"76041",title:"Prof.",name:"Pier Paolo",middleName:null,surname:"Piccaluga",slug:"pier-paolo-piccaluga",fullName:"Pier Paolo Piccaluga",profilePictureURL:"https://mts.intechopen.com/storage/users/76041/images/system/76041.jpg",biography:"Pier Paolo Piccaluga, Prof., MD, Ph.D., is currently Associate Professor of Pathology at the Department of Experimental, Diagnostic and Specialty Medicine, Bologna University School of Medicine—Institute of Hematology and Medical Oncology, and the Biobank of research at the IRCCS S. Orsola-Malpighi Hospital. He has been responsible for many years for the Molecular Pathology Laboratory. In 2018, he was appointed for teaching at the Queen Mary University of London and Jomo Kenyatta University of Agriculture and Technology, Nairobi, Kenya. He is the author of several international publications in journals such as Nature Medicine, Journal of Clinical Investigation, Journal of Experimental Medicine, Journal of Clinical Oncology, Blood, Lancet Oncology, and Lancet Infectious Diseases. Dr. Piccaluga is ranked a Top Italian Scientist (TIS) by VIA-Academy.",institutionString:"University of Bologna",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"5",totalChapterViews:"0",totalEditedBooks:"2",institution:{name:"University of Bologna",institutionURL:null,country:{name:"Italy"}}}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"16",title:"Medicine",slug:"medicine"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"280415",firstName:"Josip",lastName:"Knapic",middleName:null,title:"Mr.",imageUrl:"https://mts.intechopen.com/storage/users/280415/images/8050_n.jpg",email:"josip@intechopen.com",biography:"As an Author Service Manager my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review, to approval and revision, copy-editing and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact."}},relatedBooks:[{type:"book",id:"9508",title:"Acute Leukemias",subtitle:null,isOpenForSubmission:!1,hash:"62d01617d9844f2238de6e3630fe5641",slug:"acute-leukemias",bookSignature:"Pier Paolo Piccaluga",coverURL:"https://cdn.intechopen.com/books/images_new/9508.jpg",editedByType:"Edited by",editors:[{id:"76041",title:"Prof.",name:"Pier Paolo",surname:"Piccaluga",slug:"pier-paolo-piccaluga",fullName:"Pier Paolo Piccaluga"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7148",title:"Peripheral T-cell Lymphomas",subtitle:null,isOpenForSubmission:!1,hash:"6d80a51035b7432acf6007837213bf1a",slug:"peripheral-t-cell-lymphomas",bookSignature:"Pier Paolo Piccaluga",coverURL:"https://cdn.intechopen.com/books/images_new/7148.jpg",editedByType:"Edited by",editors:[{id:"76041",title:"Prof.",name:"Pier Paolo",surname:"Piccaluga",slug:"pier-paolo-piccaluga",fullName:"Pier Paolo Piccaluga"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6550",title:"Cohort Studies in Health Sciences",subtitle:null,isOpenForSubmission:!1,hash:"01df5aba4fff1a84b37a2fdafa809660",slug:"cohort-studies-in-health-sciences",bookSignature:"R. Mauricio Barría",coverURL:"https://cdn.intechopen.com/books/images_new/6550.jpg",editedByType:"Edited by",editors:[{id:"88861",title:"Dr.",name:"R. Mauricio",surname:"Barría",slug:"r.-mauricio-barria",fullName:"R. Mauricio Barría"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9500",title:"Recent Advances in Bone Tumours and Osteoarthritis",subtitle:null,isOpenForSubmission:!1,hash:"ea4ec0d6ee01b88e264178886e3210ed",slug:"recent-advances-in-bone-tumours-and-osteoarthritis",bookSignature:"Hiran Amarasekera",coverURL:"https://cdn.intechopen.com/books/images_new/9500.jpg",editedByType:"Edited by",editors:[{id:"67634",title:"Dr.",name:"Hiran",surname:"Amarasekera",slug:"hiran-amarasekera",fullName:"Hiran Amarasekera"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"72",title:"Ionic Liquids",subtitle:"Theory, Properties, New Approaches",isOpenForSubmission:!1,hash:"d94ffa3cfa10505e3b1d676d46fcd3f5",slug:"ionic-liquids-theory-properties-new-approaches",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/72.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2270",title:"Fourier Transform",subtitle:"Materials Analysis",isOpenForSubmission:!1,hash:"5e094b066da527193e878e160b4772af",slug:"fourier-transform-materials-analysis",bookSignature:"Salih Mohammed Salih",coverURL:"https://cdn.intechopen.com/books/images_new/2270.jpg",editedByType:"Edited by",editors:[{id:"111691",title:"Dr.Ing.",name:"Salih",surname:"Salih",slug:"salih-salih",fullName:"Salih Salih"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"58287",title:"Probabilistic Methods for Damage Assessment in Aviation Technology",doi:"10.5772/intechopen.72317",slug:"probabilistic-methods-for-damage-assessment-in-aviation-technology",body:'\nIn this chapter, the concept of a hazard in transport systems will be restricted and limited to the aviation technology. It is also assumed that these threats will be related to the possibility of the occurrence of catastrophic and signalled damage due to technical reasons caused by destructive processes, which appear during the aircraft operation. The current aircraft is characterised by a high level of reliability and durability. The reliability and durability tests of aviation technology are carried out in two different ways. The first way involves station tests of the selected units of objects and construction systems under simulated loads and operating conditions, while diagnosing the technical condition and recording data on the course of destruction processes.
\nThe second way is to use an external central computerised system of monitoring and analysing the operation process of the entire set of objects, including a system of recording operational events and an information processing system. The system of recording information obtained during diagnostic checks and detected damage divided by types, symptoms, causes and effects is of particular importance. The recorded data are used for determination of the reliability and safety characteristics, and provide the opportunity to estimate a functioning resource.
\nDespite many efforts in the processes of designing and implementation of new aircraft constructions, the occurrence of not signalled (sudden) damage, the effects of which are serious, took place. They may occur in the process of operation for many reasons, and mostly due to the lack of complete recognition of many processes that take place during the aviation equipment operation. So far, there has been also a lack of methodology for optimal shaping of construction elements based on destruction models, which would take into account all possible types of their loads and assessment of the environmental impact effects in the long-term operation.
\nFor example, it is possible to distinguish some causes of sudden (catastrophic) damage. They are as follows [1]:
The loss of the volume strength of the element, which can be damaged as a result of the occurrence of excessive permanent deformations, the occurrence of an ad hoc crack, or a fatigue crack, which exceeded the critical value.
The loss in material properties in the construction elements as a result of functioning of ageing processes.
The loss of the element’s usability as a result of the surface wear or the inclusions of foreign matters between the cooperating elements.
The random increase in the concentration of vapours of chemicals and the occurrence of circumstances conductive to uncontrolled explosions.
The random shortcuts in the electronic circuits.
All the causes leading to catastrophic damage are the subject of numerous experimental and theoretical considerations.
\nThe occurrence of catastrophic damage to the aircraft equipment usually results in serious failures or catastrophes and large losses. Therefore, it is necessary to estimate the risk of incurring these losses.
\nThe term of risk is understood as the probability of the occurrence of critical damage or an adverse event in case of the occurrence of losses. In our case, a negative phenomenon will include the occurrence of catastrophic damage to aircraft. The level of the accepted risk of negative events is determined by the frequency of their occurrence and costs. In Figure 1, a method for determination of the accepted risk range is presented.
\nDiagram for determination of the acceptable range of the risk of losses.
where R(t)—probability of failure to the catastrophic damage occurrence.
\nE[O]—expected value of the cost of developing the construction and reliability test (in order to eliminate catastrophic damage).
\nE[S]—expected value of the risk resulting from the frequency of the failure and losses as a result of the occurrence of catastrophic damage in the operation process.
\nE[K]—expected value of the total cost E[K] = E[O] + E[S].
\nFigure 1 shows the possibility of moving from the zero-risk policy of a threat to the ‘acceptable’ risk policy based on the principle ‘as low the risk, as it is reasonably achievable’.
\nThe basis for estimating the risk of threat is a forecast of the occurrence of negative phenomena during operation resulting in catastrophic damage.
\nIn this chapter, the selected models, which can be used for estimating the reliability and risk of the occurrence of catastrophic damage in the accepted time period of the device operation, will be presented.
\nBy assumption, the aviation technology has high reliability requirements, which, in practice, are implemented through special inspection procedures and appropriate design solutions involving the introduction of excesses of structure, strength, power, information, etc. The structural excess is characterised by elements or functional systems, basic and reserve-protective ones. After damage to the basic system, the protection systems start functioning. It ensures a high safety level of aircraft flights, which is one of the most important issues in the air transport. Despite these protections and great efforts of technical services, the failures that cause accidents occur.
\nThe protecting systems constituting the reserve of basic systems significantly increase the production costs and reduce the overall performance, such as capacity, range, fuel consumption, etc. They also require special treatment in the operation of aircraft, so that they have very high probability of correct functioning at the very low probability of use.
\nThe accuracy of continuous or periodic identification of the state of usability is an important issue. The person stating the state of usability of basic and reserve technical systems can make two types of errors:
an error of the first type consists of qualifying the usable device as unfit;
an error of the second type consists of qualifying the unfit device as usable;
The result of the erroneous statement on the system activating the emergency release of the landing gear was the emergency landing of PLL LOT plane, Boeing 767-300ER, on November 1, 2011 at Warsaw Chopin Airport, which will be discussed in the further part of the chapter.
\nThe wear and ageing processes of various elements are correlated with time or the functioning duration, or with calendar time in a varying degree. Generally, the construction elements and functional systems may be classified into three types:
Elements having strongly correlated parameters determining the state of usability with the functioning duration or time, which can be identified with the existence of the memory related to the past.
Elements having poorly correlated parameters of the state of usability with the functioning duration or time, which imply weak relationships of operating time with the technical condition change, wear and damage.
Elements without correlation with the operating time, number of activation, or other measure of the functioning duration, with randomly occurring damage.
In case of elements of the first group, it is possible to create the technical condition trajectory and to expect a moment of time, in which the limit state will occur. It is also possible to predict a moment of the element or unit secure taking out of service. In this case, a process of damage can be described with a suitably selected model for normal distribution, even with a small variance [2]. The suitable quantile of the random variable of functioning duration between damage can be a basis for developing a programme of diagnosing, maintenance and repairs. This group of elements can include slide bearings, gears, tyre treads of gear wheels, etc. A good model describing the time of the correct operation is normal distribution.
\nThe normal distribution sometimes constitutes limit distribution, to which many other types of distribution asymptotically approach in the operational processes of devices, together with an increase in the number of experiments. Based on operational tests, it can be concluded that the normal distribution provides an approximate (asymptotic) description of the random variable of
The random variable of
where
The shape of
The probability density of normal distribution for different values of
For
The reliability function value is calculated as follows:
\nIn order to simplify the calculations in practice, the so-called standardised variable is adopted:
\nit indicates a number of average (standard) deviation in terms of which the random variable
With
However, the formula for the reliability function is as follows:
\nDue to the fact that the integral
\nand the function
\nare called the Laplace function (integral), the final form of the equation of the reliability function will be as follows:
\nThe above presented formulas for normal distribution of life time of the aircraft elements provide the right accuracy of calculations at a high degree of homogeneity of a feature and tested objects, which is characterised by small deviation values and the standard one, that is, when the expected value
In these cases, for which \n
where
The use of the truncated normal distribution in the reliability tests of technical objects has the following practical sense. The equation for the density function of the normal distribution applies for all
however,
Because
\nwhere
\nsubstituting these figures, it is possible to obtain:
\nThe solution of the above integral includes the expression:
\nThe second group includes elements and structures operating in the variable conditions that are subject to the material fatigue, vibration, corrosion, etc. The process of damage to the other group’s elements can be described by the models with variable parameters and high dispersion, such as: gamma, log-normal, Weibull and others [2]. The selection of operating programmes is very difficult, especially in cases of aviation technology, where the failure of a function of the object’s construction system threatens the safety of people, the environment or causes significant material losses. In this case, it is important to apply the density of services, matching them to the damage threatening the safety or the most common ones.
\nWith the development of the construction, it is important to mount the diagnosing systems for tracing (monitoring) the technical condition and signalling the pre-failure states in the units and functional systems. A certain way out of the situation involves monitoring of the course of induced forces with the use of a system of recorders adapted to record all relevant operational events, especially those threatening the safety of use. With the diagnosing and IT system for monitoring the state and the process of damage, it is possible to determine the area, in which the technical condition trajectory is placed, or to identify the durability resource.
\nIn this distribution, it is assumed that for randomly selected moments of
The density function of this probability is as follows:
\nwhere
\n\n\n
For total k, there is the relationship:
\nand the gamma distribution is called the Erlang distribution.
\nIn this case,
In Figure 3, the gamma distribution density for various values
does not depend on the number of such increases, which occurred in time preceding
Gamma distribution density with different values
In case of the assumption that
this object becomes unfit for further correct operation in the system,
where
By using the formula for the function of
The expected value
The elements of the third group are subject to the exponential reliability law, in which the constant intensity of damage is assumed. The damage have a random nature and most often come from:
manufacture errors (material and technological errors);
overloads of a different nature;
non-compliance with the instructions for use or operation technology.
The elements of the third group include bodies, glass housings and covers made of plastic, electronics components, etc.
\nIf (
the exponential distribution is used.
\nThe
and
where
\n\n\n
Moments of the exponential distribution are given by the following formula:
\nThe equality \n
Example courses of the exponential distribution density for different values of the parameter
When
When (
where
\nwhere
\n\n\n
Therefore, for the purposes of operation, it is possible to use the following formula:
\nIn relation to the fact that
then,
and for the exponential distribution,
In Figure 5, the reliability functions \n
Reliability function courses; distribution: a—geometric, b—exponential.
Another way, which makes it possible to estimate the probability values of the occurrence of catastrophic damage in the aircraft devices, can include the use of models, including the limit state.
\nA quantitative description and probability evaluation of damage to the basic and protection systems of the aircraft can be carried out in accordance with the postulates of the Poisson process [4].
\nAssuming that:
probability of damage is directly proportional to the length of the concerned time period and the number of operated aircraft;
proportionality factor identifying the risk of damage is constant;
The following system of equations is right:
\nwhere
\n\n\n
\n\n
\n\n
\n\n
\n\n
By dividing Eq. (37) by \n
For the system of equations (38), the initial conditions are as follows:
\nEquation (38) is a linear differential equation and it is solved recursively. First, \n
The solution of the system of equations (39) takes the form of:
\nThe probability that n damage requiring the launch of protection systems will occur in the time interval (0,
The integral \n
where
\n\n\n
For a single aircraft, the probability of the damage occurrence during the considered
where
\nSince
Hence
\nBy substituting Eq. (43) to (42), the following is obtained:
\nWith the relationship (44), it is possible to estimate the probability of the failure occurrence in a single aircraft.
\nThe probability of correct aircraft functioning is expressed by the following relationship:
\nIn order to estimate the average number of failures during a given period for the operated aircraft park, the following relationship can be used:
\nwhere
\nWe are often interested not only in the probability that
in the interval (0,
in the interval (
in the interval (
The probability of the occurrence of the said number of damage, that is,
where
\nThe above recorded probability, considered as a function of
Hence
\nWith the help of the relationship (49), the estimator of
Hence, relationship (47) takes the following form:
\nwhere
\nRelationship (50) makes it possible to estimate the probability of the damage occurrence in a single aircraft within a given time interval.
\nThese models can be used for determination of the probability of the occurrence of various negative events in the devices for the following cases:
when the parameter, specifying their state, will exceed the limit state;
when a chance of the catastrophic damage occurrence is constant along the increasing parameter, which evaluates its state;
when a chance of the catastrophic damage occurrence increases together with an increase in the parameter, which evaluates its state;
when the parameters determining a chance of the damage occurrence constitute random variables.
It is assumed that:
The device’s technical condition is determined by one dominant diagnostic parameter. Its current value is determined by \n
A change in the diagnostic parameter value occurs only during the aircraft flight:
The parameter \n
May \n
In order to describe an increase in the parameter value in the random basis, the following differential equation was adopted:
\nwhere
\n\n\n
\n\n
\n\n
Eq. (51) in the function notation adopts the following form:
\nwhere
\n\n\n
After taking into account the physics of the diagnostic parameter increase and appropriate transformation, the Fokker-Planck differential equation is obtained from Eq. (52). As a result of solving this equation, the following density function is obtained:
\nwhere
\n\n\n
\n\n
The probability of the catastrophic damage occurrence with the use of the relationship (53) can be presented in the following way:
\nwhere
\n\n\n
The risk level of the catastrophic damage occurrence in the operating time function can be determined after transformation of relationship (54) as follows [5]:
\nwhere
In point 5, a case of the device operation, when the catastrophic damage occurred only after exceeding the limit state by the diagnostic parameter value, was considered. Currently, the next case is considered, when the opportunity of additional one (the second type of catastrophic damage), possible to be implemented in every moment of the aircraft operation, is added to the previous one.
\nAdditionally, the intensity of the occurrence of this type of additional damage will be introduced:
\nwhere
\n\n\n
\n\n
\n\n
Other necessary parameters and magnitudes in this point will be the same as in point 4. The differential equation, in order to describe an increase in the value of the diagnostic parameter changes, adopts the following form (in the function notation):
\nFrom Eq. (58) after transformation, the following partial differential equation is obtained:
\nwhere
\n\n\n
\n\n
\n\n
In Ref. [2], it was shown that the equation solution (59) adopts the following form:
\nwhere
\nBy using relationship (62), it is possible to determine the additional catastrophic damage occurrence within the range of \n
Hence, it is possible to write the relationship for the total probability of the occurrence of both types of catastrophic damage in the time interval \n
The formula for the aircraft reliability adopts the following form:
\nwhere \n
In order to solve the problem, The Yule’s process will be used by carrying out its modification. The method of this modification is provided in Ref. [6]. In this case, it is necessary to perform the diagnostic parameter value discretisation. The discretisation method is provided in Figure 6.
\nDiscretisation diagram of the diagnostic parameter.
where
\n\n\n
\n\n
\n\n
\n\n
May \n
For these arrangements, it is possible to arrange the following system of the infinite number of equations:
\nAfter division of both sides of \n
The initial condition for each of these equations is as follows:
\nThe system of Eq. (70) is solved recursively. Having the results of the solved system of equations, it is possible to determine the probability (reliability) that in the time interval \n
The probability of the fact that to the moment of \n
After the adding up operation performance, the following form of the solution is obtained [6]:
\nHence, the time distribution density to the moment of the catastrophic damage occurrence.
\nIt is assumed that the aircraft operation is done in such a way that the following arrangements and assumptions are correct:
In order to assess the technical condition,
Instead of the diagnostic parameter values in the reliability assessment, the following deviations are used:
where
Deviation values
The deviation limit values are \n
It is assumed that \n
The change in
The speed of changes in the deviation values can be described with the use of the following relationship:
where
By using relationship (78), it is possible to determine the deviation value during one flight:
The intensity of the aircraft flights λ is determined by the following relationship:
where
Δ
By using the intensity of flights
It is assumed that the aircraft is operated. The task of the technical service is, among others, not to allow for the occurrence of signalled damage and to maximally limit the possibility of the occurrence of catastrophic damage, which is the cause of the aircraft failures and crashes.
It is assumed that the sets of signalled and catastrophic damage to the aircraft are separate. Hence, the aircraft reliability in this case can be written in the following form:
where
\n\n
\n\n
Despite the attempts and great effort of technical services, currently, it is impossible to completely eliminate the risk of the catastrophic damage occurrence.
\nIt is adopted that in case of a single flight of the aircraft, the probability determining the possibility of the catastrophic damage occurrence is Q. The progressive technical service of the aircraft is to prevent this probability increase together with an increase in operating time.
\nUnder the adopted probabilistic assumptions, a description of the deviation increase of diagnostic parameters in the function of the aircraft operating time can be considered separately for each diagnostic parameter. In view of the above, it is assumed that the process of deviation changes of
May \n
For the adopted arrangements, the dynamics of changes (increase) of
where
\n\n\n
\n\n
Hence \n
Eq. (83) expresses the following sense. The probability of the fact that in the moment of \n
Differential Eq. (83), in the function notation, adopts the following form:
\nwhere
\n\n\n
Differential Eq. (84) can be transformed to the partial differential equation, with the use of the following approximation:
\nBy substituting Eqs. (85) to (84), it is possible to obtain:
\nHence, after simplification, the following is obtained:
\nBy dividing two sides of (87) equation by Δ
where
\n\n\n
\n\n
\n\n
The solution of the specific Eq. (88), which meets the following conditions, is searched for:
\nwhen \n
For such an adopted condition, the equation solution (88) adopts the form:
\nwhere
\nRelationship (90) determines the average value of the deviation, and relationship (91) determines the deviation variance.
\nBy using relationship (89), the reliability in the aspect of the damage signalled for
By taking into account all the diagnostic parameters and adopted assumptions, the reliability formula adopts the following form:
\nNow the relationship for the second component of R1(t) aircraft reliability is determined due to the catastrophic damage.
\nThe catastrophic (sudden) damage is caused by incomplete control and knowledge of the aircraft technical condition.
\nIt results from the aircraft operation that a group of damage occurs as a result of sudden changes in measurable and non-measurable parameters due to the inability to observe the changes of their values. The exceeding of the applicable limits also affects an increase in the risk of the aircraft catastrophic damage occurrence.
\nThe damage intensity plays a basic role in the probabilistic description of the occurrence of this type of damage.
\nThe intensity of damage is expressed by the following relationship:
\nwhere
\nFrom relationship (94), after transformation, it is possible to obtain the following differential equation:
\nEq. (95), for the initial condition \n
If
\nIn order to use relationship (95), it is important to estimate
Time
In order to estimate
The theoretical average time of given operation to the moment of the catastrophic damage occurrence is:
\nThe average value of the aircraft operating time (from the moment of the catastrophic damage occurrence) calculated on the basis of the observation will be:
\nHence
\nIf the probability of the sudden damage occurrence during one flight is known, the intensity of this type of damage can be estimated by the following relationship:
\nThe relationship for estimation of
After taking into account relationships (93) and (102), the aircraft reliability formula will be:
\nBy starting the modification of the applied method in point ‘8.2’, the following additional assumptions are adopted:
The aircraft catastrophic damage causes its withdrawal from operation;
It is assumed that there is one dominant parameter among diagnostic parameters. Its dynamics of changes is the greatest, and due to its causes, the signalled damage is formed in the quickest manner.
The probabilities associated with the aircraft flight frequency and the possibility of its withdrawal from operation constitutes separate, independent sets of events.
For such specified probabilities, the following equation is right:
\nBut
\nHence
\nThe description of deviation changes in the dominant diagnostic parameter currently marked with
May
By using relationship (109) and assuming that
Eq. (109) in the function notation adopts the following form:
\nEq. (111) is transformed into the partial differential equation with the use of the approximation (85) and relationship (109).
\nFor greater transparency,
After completing these operations, the following is obtained:
\nHence
\nFinally, the following partial differential equation is obtained:
\nwhere
\nΔ
Eq. (114) is more general than the Fokker-Planck equation, written in the form of the relationship (88).
\nEq. (114) has an additional element ‘-
In order to present the equation solution (114), the equation solution (88) will be used. If the equation solution (88) constitutes the relationship (89), then, the equation solution (114) constitutes the following function:
\nwhere
\n\n\n
In order to justify that the function (118) is the equation solution (114), the following transformation is presented:
\nA derivative after the relationship time (118) is calculated.
\nHence, it can be observed that the function (118) is the equation solution (114).
\nFunction (114) has the density function characteristics, because:
\nBy using relationship (118), the aircraft unreliability is determined
\nThus, it is possible to write that:
\nwhere
\n\n\n
\n\n
\n\n
\n\n
Thus, the aircraft reliability will be:
\nHence
\nThus, the aircraft reliability formula will be:
\n