Etiologic classification of orbital tumors causing secondary glaucoma.
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These books synthesize perspectives of renowned scientists from the world’s most prestigious institutions - from Fukushima Renewable Energy Institute in Japan to Stanford University in the United States, including Columbia University (US), University of Sidney (AU), University of Miami (USA), Cardiff University (UK), and many others.
\\n\\nThis collaboration embodied the true essence of Open Access by simplifying the approach to OA publishing for Academic editors and authors who contributed their research and allowed the new research to be made available free and open to anyone anywhere in the world.
\\n\\nTo celebrate the 50 books published, we have gathered them at one location - just one click away, so that you can easily browse the subjects of your interest, download the content directly, share it or read online.
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IntechOpen and Knowledge Unlatched formed a partnership to support researchers working in engineering sciences by enabling an easier approach to publishing Open Access content. Using the Knowledge Unlatched crowdfunding model to raise the publishing costs through libraries around the world, Open Access Publishing Fee (OAPF) was not required from the authors.
\n\nInitially, the partnership supported engineering research, but it soon grew to include physical and life sciences, attracting more researchers to the advantages of Open Access publishing.
\n\n\n\nThese books synthesize perspectives of renowned scientists from the world’s most prestigious institutions - from Fukushima Renewable Energy Institute in Japan to Stanford University in the United States, including Columbia University (US), University of Sidney (AU), University of Miami (USA), Cardiff University (UK), and many others.
\n\nThis collaboration embodied the true essence of Open Access by simplifying the approach to OA publishing for Academic editors and authors who contributed their research and allowed the new research to be made available free and open to anyone anywhere in the world.
\n\nTo celebrate the 50 books published, we have gathered them at one location - just one click away, so that you can easily browse the subjects of your interest, download the content directly, share it or read online.
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In the last decade the theme of embodiment has received a growing attention among researches and practitioners from design and related fields. Research on embodiment is primarily concerned with how we use our bodies to shape the ways we perceive, feel and think [1]. A variety of disciplines, spanning from Philosophy to Human-Computer Interaction (HCI), have addressed different aspects of embodiment, and this has led to the emergence of more specific approaches. One of these approaches, known as
The present discussion takes Aesthetic Interaction as a conceptual and methodological tool to analyse and better understand the process of placemaking. As a general notion, the term
In order to analyse the relationships between Aesthetic Interaction and placemaking, this paper presents an empirical study on the series of interactive artworks
As the concepts of Embodied Interaction, Aesthetic Interaction and placemaking are essentially interdisciplinary, this section draws on different disciplines to outline the main characteristics of these concepts and their contributions to the study of urban interactive installations. Within the field of HCI, Dourish authored a seminal work,
The growing interest on the experiential and corporeal realms of human-artefact relationships has inspired a range of subdisciplines to emerge [5]. Especially related to the case study of this paper are the fields of embodied engagement, whole body interaction and kinesthetic interaction (e.g., [11–13]). What these fields have in common is the consideration of the interacting, living, active human body as the main source of analysis and design; such idea is opposed to Cartesian and cognitivist approaches that tend to reduce users as disembodied information processors [1, 14].
Interestingly, the main ideas and concepts outlined above have also informed research and design in Architecture. While Interaction Design takes the notion of embodiment from the perspective of a
Several disciplines have discussed the concept of
More recently, placemaking has been regarded as a collaborative process which aims to maximise the “shared value” of public spaces, by focusing on its social, cultural and physical identities [25]. The two core principles of placemaking have been summarised as (a) focus on designing cities for people; and (b) inclusion of citizens in the decision making process of design [22]. Such principles highlight the role of local communities in the planning and design of places. What makes communities key elements in the process of placemaking are their unique attributes—for example, trust and support networks, common experiences and interests, types of transactions, history and proximity [7]—attributes that, together, help to constitute and qualify places over time. In a certain sense, communities make their own places by imbuing their everyday environments with shared values, habits and identities; when “material and spatial elements are given life by the meanings, associations and experiences people inject into them during daily life” ([26], p. 141).
Urban art installations can arguably contribute to the process of placemaking by enticing a broad variety of interactions. People may interact not only with the installations themselves, but also with other people, for example, by starting a conversation prompted by the installation—the process known as
Not surprisingly, embodied, playful and aesthetic modes of interaction have been employed for many years in urban spaces, especially in the context of parks, playgrounds or seasonal initiatives such as funfairs, action- or adventure-themed events and, more recently, urban prototyping festivals. What seems to be singular in the current turn to embodiment in Urban Design is an emphasis on the
Part of these new initiatives has been built as permanent additions to the city: such as the
Left: Charlotte Ammundsens square, image courtesy of Danish architecture centre; right:
However multifunctional, playful or enticing these contemporary projects are, they all seem to share an underlying principle: they seek to bring life to the city by proposing spatial and social experiences that are fundamentally rooted in the human body. In other words, these projects explore Aesthetic Interaction as a platform of placemaking. The
This section presents an empirical study of the
Two versions of the modified social benches.
Besides their sculptural quality that sparks people’s attention, the
After a bottom-up, exploratory approach of the installations in Southbank Centre, 4 out of 10 different versions of the
they were installed in the same area, so all of them could be captured by a single photograph taken from a distant, inconspicuous position, as shown in Figure 3.
the designs of these benches present significantly different bodily and social affordances—some benches encourage a playful and exploratory behaviour, while others invite people to relax and socialise (Figure 4).
Overview of the area highlighting the four art installations.
Different behaviours towards the benches, from playing (left) to chatting (right).
The primary methodological tools used for this study were on-site observations and time-lapse photography. Observations are an important tool because they allow a gathering of data that might be considered as an objective view of human behaviour. By observing we can learn about the environment without taking account of people’s intentions—something important, given that social activities in urban contexts give rise to patterns of use and movement that are independent of the intentions of individuals [31]. Time-lapse photography was used to record and analyse the interactions. Since the study did not focus on fine details of discrete interactions, but rather on patterns of bodily engagement and social behaviour on the broader urban scale, time-lapse photography seemed a suitable alternative to video recording, while being a technique that has been adopted by influential studies on human behaviour in outdoor settings [24].
The data collection was mainly conducted in August and September 2016, with a total of 15 recording sessions. Each recording session lasted between 30 and 35 min and employed a small action camera. The camera was positioned at the same spot in all sessions, and it was set to take one photograph at intervals of 60 s. The sessions took place at different times of the day and different days of the week, so as to capture the varying conditions of the urban and social setting.
In order to analyse the bodily, social and spatial interactions around the benches, the people recorded in the area of study were classified in three main categories: players, participants and spectators. Each of these categories tries to address the distinct ways in which people seemingly experience the art installations, both from a bodily, social and spatial perspective.
The category of
The images captured in Southbank Centre suggest that this playful behaviour is motivated by two main reasons: first, one’s own curiosity to explore and to test different movement possibilities, that is, the bench’s affordances for action and play. In this group were recorded the most performative people, who engaged in all sorts of acrobatic movements and postures, such as climbing, hanging or sliding on the benches. The second important motivation for adopting a playful behaviour is to pose for photographs or videos. Playing with the benches to have one’s portrait taken was more frequent among adults (Figure 5).
Different motivations among players: playing for the sake of playing (left) and playing to be photographed (right).
Unlike conventional sitters who pose on conventional benches, most of the people being photographed amid Jeppe Hein’s artworks deliberately adopted an unusual or “funny” body posture, so as to reflect the playful and liberal character of the installations. In either cases—playing for the sake of playing or playing to be photographed—the interaction of players was markedly dynamic and fleeting.
Some people were recorded at the benches for a relatively long time—typically more than 3 min—though they were not regarded as players. Unlike players, the category of
Participants’ behaviour points to a significantly different relationship to the art installations and the space around them, with respect to the bodily, the social and the experiential realms. If, for players, the benches stand out as urban sculptures calling for sensorimotor explorations, participants seem to regard Jeppe Hein’s artful installations as a set of conveniently located urban furniture, where one can sit to wait for a friend, use the mobile or simply to enjoy the panorama of river Thames while resting the legs or chatting with another participant.
Nevertheless the distinction between players and participants is not always straightforward. Part of the recorded people manifested postures and behaviours seemingly located somewhere between the performative actions of players and the more relaxed forms of engagement commonly found among participants (Figure 6).
Bodily engagements at the boundary between participation and play.
In such cases,
The category of
Multiple social roles in a snapshot: two persons sit (participants); a kid climbs on the right of the bench (player); four spectators stand nearby (two at the front and a couple behind the bench). Four passers-by can also be seen on their way.
For the purposes of this study, the most important characteristic shared by spectators is that, although referring to people who are not physically engaged with the art installations at a given time, spectators are potential players, that is, they may become active players, either in a matter of seconds or in their possible next visits to the area. What distinguishes spectators from mere passers-by are the bodily, temporal and social relationships between the person, the art installation and the place. Firstly, beholding implies some duration—for this study, at least a few seconds. It also entails bodily and social dimensions: it is a physical posture, a gesture which signals to nearby people that something interesting might be going on. By gazing at the benches, spectators not only stimulate passers-by to do the same. In fact, spectators help feed the whole cycle of social roles around the installations: some of the passers-by may stop around to observe or photograph the benches, and part of these people may go one step further and become players, eventually creating a “social buzz” in the place [27].
Especially during busy recording sessions, several people were observed at the vicinities of the benches, either leaning against the railings or sitting on the ledge beneath them (Figure 8).
People standing and sitting by the railings.
Importantly, most of these individuals remained at the same spot for several minutes, and they were not identified as part of a group engaged with the benches. In such cases, these individuals were not included as spectators, because their behaviours seem to best characterise the act of resting or waiting—but one that would apparently take place irrespective of the presence of the benches.
In order to present and analyse the data collected on-site, the four versions of the “Modified Social Benches” are identified as A, B, C and D, as shown in Figure 9:
The four versions of the benches analysed in the study.
A first glance at the striking shapes above suggests that each design affords different types of bodily and social behaviour. Likewise, each version of the bench may also result in particular forms and levels of aesthetic interaction. This section aims to clarify how these different forms of aesthetic interaction may affect the dynamics of placemaking. Chart 1 presents a synthesis of the findings, with the distribution of players, participants and spectators around each bench throughout the 15 recording sessions of the study.
Distribution of social roles for each version of the benches.
The data above reveal that benches A and D share a similar character: in addition to encouraging playful, performative movements, these benches also succeeded in attracting a significant number of spectators around them. An average of 22.67 players per session were registered on bench A, and in only one session (7th September) no players attended. Bench D achieved a slightly higher average of players (22.87 per session), who were also consistently present throughout the study. As for spectators, bench A attracted the largest number of them—an average of 52.87 spectators per session—which, in most occasions, surpassed the number of players and participants altogether. Bench D saw an average of 32.40 spectators, and their distribution was not so dominant as that verified in bench A.
There is an important qualitative difference that helps explain the quantitative data outlined above. Among the players who engaged with bench A, most of them were children, who found in the slope-shaped installation a particularly amusing affordance for sliding. Thus, for the larger part of the players on bench A, the installation was literally a toy, a piece of playground. And, as one would expect to find in an ordinary urban playground, these young players were accompanied by their parents, relatives or friends, most of whom added up to the number of spectators around the bench (Figure 10).
Social gatherings around bench A as a result of children playing.
Bench D, on the other hand, presented a rather distinct profile of players. Children, adolescents and young adults likewise experienced bench D by performing a wide variety of corporeal movements and postures. And, while the steep shape of bench A imposed serious difficulties for more than one person to play at a time, the circular design of bench D allowed two, three or even more players to explore the installation simultaneously (Figure 11).
A young couple (left) and a group of children (right) playing simultaneously with bench D.
All these factors contributed to a smaller proportion of spectators around bench D if compared to bench A. In fact, with regard to the social roles, the design of bench D proved to be the most versatile one among the four versions of benches analysed here, as, in most sessions, the three social roles described in this study—players, participants and spectators—were recorded around bench D (Chart 1).
Benches B and C also function as platforms for social encounters, but they share a different character if compared to benches A and D. As shown in Chart 1B and C, the large majority of people recorded at benches B and C were qualified as participants. With regard to Aesthetic Interaction, this finding points to a very different experience, in terms of its bodily, social and spatial aspects. Firstly, the participants recorded at benches B and C found themselves in relaxed sitting positions: their bodies were laying on Jeppe Hein’s art installations as they would be on any other conventional bench. Secondly, many of these participants remained sat for several minutes, while resting alone or talking to other people in different social formations (Figure 12).
A mother rests on bench B (left) while the “social character” is evident at bench C (right).
Thirdly, the spatial and social logic of the behaviours observed around benches B and C can be described as self-contained and contemplative: people did not feel compelled to engage in any sort of play with benches B and C, and only a few of them were recorded as spectators, with averages of 8.27 spectators for bench B and 12.33 for bench C (Chart 1B and C).
The main findings summarised above suggest that some correlations between Aesthetic Interaction and placemaking might exist. It was argued that a place consists of a spatial setting where people feel stimulated to go and to stay. Then, based solely on Chart 1A–D, one is tempted to conclude that bench C is the most successful in terms of placemaking, simply because bench C attracted the largest number of people (average of 110.80 people per session). However, the data compiled on Chart 1A–D refers to discrete occurrences of interaction, and not discrete persons, which means that the same individual recorded for, say, 8 min resting on a bench corresponds to eight participants. Considering that many participants captured at bench C remained sat for several minutes, in fact the total number of
A group of ladies with a baby settle on bench C: from 12.03 pm (left) to 12.30 pm (right) these participants remained unchanged.
On the other hand, precisely because bench C encourages people to stay on it, other people often find no space to sit, interact or socialise on bench C, thus limiting the potential of this bench to create more fleeting modalities of social encounters.
Bench B shares with bench C the elementary character of “a bench to sit on”. Nonetheless, the study shows that, compared to bench C, bench B presents a rather distinct quality with regard to social gatherings. The sitting surfaces of bench B are curved and discontinuous; as a result, bench B is not as comfortable as bench C, and it accommodates only two individuals at a time—whereas up to six people were found simultaneously on bench C. Encouraging neither extended permanence nor different social arrangements, the design of bench B turns out to be the weakest of the four analysed versions with respect to placemaking. In addition, Bench B resists easy classification: although visually striking, its design makes bench B something in-between urban sculpture and urban furniture. In light of Aesthetic Interaction, this generates a problematic situation where people do not feel sufficiently compelled to engage their bodies in playful, movement-based experiences, and, at the same time, they do not feel so much compelled to sit and to stay.
The case study suggests that benches A and D are the most effective in terms of placemaking. These benches attracted high numbers of people (averages of 84.2 and 68.53 people per session, respectively). Most importantly, benches A and D revealed the highest distribution of players, participants and spectators across the recording sessions, which means that benches A and D provided more variegated experiences of bodily and social interactions around them. Not displaying a highly dominant presence of participants—such as those verified on benches B and C—means that more people were given the opportunity to experience benches A and D in qualitatively different manners, such as playing, resting or observing the activities around the benches. Unlike bench B, the striking shapes of benches A and D are unambiguously aimed at playful, exploratory sensorimotor encounters. This versatile, playful and action-oriented character makes benches A and D work in favour of placemaking, by imbuing the urban space with a very particular identity and life through social activities.
This paper presented a case study of the
The mapping and analysis of the diverse social encounters and bodily actions triggered by the art installations suggest a correlation between Aesthetic Interaction and placemaking. Drawing from the main findings, it is possible to argue that urban installations encouraging playful, action-oriented and sensorimotor encounters tend to be more effective to placemaking than installations affording static modalities of social activities. If place is characterised as a lively setting offering different modalities of social encounters and meaningful experiences, then urban artefacts that provide people with a broader variety of social and sensorimotor experiences (like benches A and D presented in this study) seem to better define lively places in comparison to other types of artefacts (like benches B and C).
The case study presented in this paper is part of a research funded by CNPq.
With the advent of constantly evolving and advancing ophthalmic imaging techniques as well as surgical modalities in the field of ophthalmic diseases, diagnostic accuracy, and treatment outcomes of ocular as well as orbital tumors have improved remarkably over the past few years. Raised intraocular pressure (IOP) is known to be one of the presenting features or associated finding for numerous ocular as well as orbital tumors. Ocular and orbital tumors can cause secondary glaucoma due to various mechanisms. They often pose a diagnostic challenge as well as a therapeutic dilemma owing to the complex pathophysiology involved. A thorough clinical evaluation, appropriate index of suspicion and optimum use of ancillary testing can lead to a proper diagnosis and management in such scenario.
Intraocular tumors that can lead to secondary glaucoma are malignancies like iris melanoma, iris metastasis, iris lymphoma, ciliochoroidal melanoma, retinoblastoma as well as benign pathologies like iris melanocytoma, benign ciliary body medulloepithelioma, diffuse choroidal hemangioma. [1] Indicators for a possible underlying intraocular tumor are, markedly elevated and often asymmetric level of IOP, acquired iris heterochromia, glaucoma non-responsive to optimum treatment or accompanying distinctive ocular features. [1, 2] The mechanism by which these tumors can cause secondary glaucoma varies with tumor type, size, and extent of the main tumor as well as seeding, tumor location, growth pattern, ongoing treatment along with secondary features related to the tumor. [3] Iris and predominantly ciliary body tumors located in anterior segment can cause glaucoma by direct infiltration of anterior chamber angle or because of iris neovascularization; while large tumors originating in retina or choroid are likely to cause glaucoma following iris neovascularization because of long standing or total retinal detachment or secondary angle closure. [1, 2]
Orbital tumors which can be congenital, traumatic, inflammatory, vascular, or neoplastic in origin may cause secondary glaucoma due to mass effect or anatomical and vascular changes leading to raised IOP [4] Orbital tumors causing raised orbital pressure may directly increase the IOP by increasing hydrostatic pressure around the globe or indirectly by raising the episcleral venous pressure.
Management of secondary glaucoma due to ocular and orbital tumors depends on both tumor characteristics and glaucoma related factors. Treatment of primary tumor may lead to IOP control in some cases while for others, management options include medical management, laser trabeculoplasty, transscleral cyclophotocoagulation, anti-VEGF injections, minimally invasive glaucoma surgery (MIGS), filtering or shunting surgery or enucleation. Glaucoma surgery like filtering or shunting procedure can be performed with due caution in proven benign or completely regressed tumors post-treatment. Such surgeries in an eye with suspected but unproven benign/malignant ocular tumor must be avoided to prevent unintended iatrogenic tumor dispersion or seeding especially in cases with iridociliary tumors or retinoblastoma.
Direct mechanism-
Solid tumor invasion- related outflow obstruction
Infiltrative tumor -related outflow obstruction
Trabecular meshwork seeding
Indirect mechanism-
Angle closure from neovascularization
Angle closure (compressive and rotational)
Ghost cell- Hemolytic
Elevated episcleral venous pressure
Anterior uveal tumors known to cause secondary glaucoma are iris/ciliary body melanocytoma, iris melanoma (nodular or diffuse), ciliary body melanoma (nodular or ring melanoma), iris lymphoma and iris metastasis. Direct invasion of the anterior chamber angle by infiltration followed by neovascularization and trabecular meshwork tumor seeding are the common etiologies of raised IOP in iris tumors; while pigment dispersion followed by direct angle invasion are the common etiologies for same in pigmented ciliary body tumors. [1, 2, 5, 6]
(A) Slit lamp image of iris melanocytoma; (B) Gonioscopy image of iris melanocytoma with extension of pigmentation up to the angle, (C) ultrasound biomicroscopy (UBM) image of iris melanocytoma appearing as irregular hyperreflective lesion on iris surface; (D) large iris melanocytoma leading to raised IOP due to angle closure glaucoma (compressive angle closure) {image credit for
Suspected melanocytoma can be observed cautiously. They are very rarely known to show malignant transformation. [9] Clear corneal approach fine needle aspiration biopsy, minimally invasive Finger Iridectomy technique (FIT), iridectomy or iridogoniocyclectomy can be utilized to obtain histopathological diagnosis in atypical iris nevi and suspected melanocytoma. [7, 10] Secondary glaucoma demonstrating melanocytoma eyes can be treated medically, by transscleral photocoagulation, by sector iridectomy or with glaucoma filtration surgery. [7, 8, 11, 12] However, a diagnostic confirmation of the lesion by prior biopsy and histopathology is mandated before planning a filtering surgery. Local surgical resection can be used to treat the secondary glaucoma caused by necrotic iris melanocytoma. [8, 13] Enucleation is reserved for painful blind eyes or eyes with absolute glaucoma.
(A) Slit lamp image of iris melanoma showing correctopia, ectropion uveae and extension up to the angle, (B) slit lamp image of diffuse iris melanoma presenting with angle closure, (C) slit lamp image of ciliary body melanoma with iris infiltration presenting as secondary glaucoma with hyphema. (D) Gonioscopy image of blood vessel (black arrowhead) at the anterior chamber angle in a case of diffuse iris melanoma with angle closure depicted in
Management of iris and iridociliary melanoma depends upon tumor size, location or extent, tumor seeding and presence of tumor related glaucoma. [15, 20] Local resection (iridectomy, iridocyclectomy), plaque brachytherapy, proton beam radiotherapy and enucleation are available treatment options for both nodular as well as diffuse iris melanoma. [6, 15, 20, 21] Secondary glaucoma in association with iris melanoma can be managed with medications, transscleral photocoagulation or laser trabeculoplasty. [22] Antivascular endothelial growth factor (anti-VEGF) injections can be tried in neovascular glaucoma. [23] Cases with refractory glaucoma resulting in blind painful eyes may warrant enucleation. [24] Filtering, shunting surgery or MIGS should be avoided in eyes with untreated tumor to prevent tumor spread outside of the globe. Diffuse iris melanoma or trabecular meshwork melanoma if misdiagnosed or missed prior to performing above named procedures can warrant enucleation for further tumor control. [3, 19]
(A) Slit lamp image of iris and ciliary body metastasis from lung adenocarcinoma showing correctopia, ectropion uveae, neovascularization of iris presenting with raised IOP (B) Ultrasound biomicroscopy image of iris metastasis with blunting of anterior chamber angle and thickened ciliary body (C) Slit lamp image of large choroidal melanoma presenting with intratumoral hemorrhage and raised IOP. (D) Ultrasound B scan of lesion in (C) showing low to moderately reflective choroidal melanoma with surrounding detached retina {image credit for
Other disorders like: Multiple myeloma, a malignant proliferation of plasma cells characterized by monoclonal production od immunoglobulins; Juvenile Xanthogranuloma, a benign histiocytic skin disorder can also affect anterior segment and lead to raised IOP. [2]
Contrary to traditional thinking, a recent study of analysis of glaucoma drainage device surgery for control of IOP in treated (totally regressed) uveal melanoma (both anterior as well as posterior) did not find a greater risk of local or extraocular recurrence after a median follow up of 2 years. [42] However, further analysis with larger sample size and longer follow up duration is warranted, and caution needs to be exercised while deciding regarding treatment options for control of IOP in such cases.
(A) Montage fundus image of choroidal metastasis from breast carcinoma presenting with multifocal lesions, retinal detachment and raised IOP. (B) Posterior pole fundus image of the same patient (A) showing radiation retinopathy after stereotactic radiotherapy (45Gy) (C) Fundus picture showing circumscribed choroidal hemangioma.
(A) Group E retinoblastoma presenting with total retinal detachment, iris neovascularization and neovascular glaucoma (clinical risk factors) (B) iris neovascularization (black arrowhead) (C) post chemotherapy tumor necrosis induced vitreous hemorrhage and secondary glaucoma in an eye with retinoblastoma (D) secondary glaucoma and sterile orbital inflammation in a case of retinoblastoma on systemic chemotherapy.
In instances where patient seeks attention with glaucoma as the presenting feature, a detailed work up involving slit lamp examination, dilated fundus examination, gonioscopy of anterior chamber angle, high frequency ultrasound microscopy (UBM) and ultrasound B scan of posterior segment will provide essential clues about diagnosis of possible intraocular tumor. Initial management with IOP lowering medications should be the first line treatment with simultaneous investigation for underlying cause. [2] When the tumor presents with atypical features or causes diagnostic uncertainty, a diagnostic biopsy is warranted in managing such case of secondary glaucoma. [55] Systemic work up with the help of positron emission tomography (PET) CT scan can come in handy while evaluating a case of possible secondary ocular metastasis by highlighting an existing primary malignancy elsewhere.
The orbit is a pyramidal structure limited by bony walls except from anteriorly where it is limited by soft tissue i.e., orbital septum and eyelids. Thus, any instances of increased orbital volume may lead to increased hydrostatic pressure in the orbit. This increased orbital pressure can have a direct effect of IOP by raised hydrostatic pressure around the eye or indirect effect by compression of episcleral and orbital veins raising venous pressure. The episcleral venous system mainly empties into the anterior ciliary and superior ophthalmic veins and eventually draining into cavernous sinus. Thus, any disease process that might affect this drainage pathway due to structural, occlusive, compressive, or destructive pathophysiology can alter and raise IOP causing secondary glaucoma. [4] Focal mass effect due to tumors or swollen extraocular muscles may directly compress the eye globe leading to raised IOP while, vascular changes affecting venous pressure due to compression of episcleral veins or altered arterio-venous flow may also increase IOP indirectly.
Table 1 summarizes the broad etiological classes of orbital tumors leading to rise in IOP and secondary glaucoma. Open angle glaucoma is more common in the listed diseases however, angle closure along with acute angle closure glaucoma has also been reported in variety of pathologies.
Sr. No | Etiology | Example |
---|---|---|
1 | Inflammatory | Non-specific Orbital Inflammatory Disease (NSOID) Thyroid eye disease Orbital granulomatous disease Orbital Foreign Body granuloma Juvenile Xanthogranuloma (orbital histiocytosis) |
2 | Vascular | Carotid-cavernous fistula (Direct or Indirect) Arterio-venous malformations Orbital varix Cavernous hemangioma Orbital lymphangioma |
3 | Neoplastic | Orbital osteoma Lymphoproliferative disorders Optic nerve glioma Optic nerve meningioma Neurofibromatosis Lacrimal gland tumors Primary orbital melanoma |
4 | Secondary | Orbital metastasis (from breast, lung carcinoma) Orbital chloroma (Acute myeloid leukemia) Multiple myeloma Invasive (secondary) ocular melanoma Extra-scleral (orbital) extension of retinoblastoma Invasive (secondary) squamous cell carcinoma |
5 | Miscellaneous | Orbital amyloidosis Mucopolysaccharidoses Phakomatosis (Neurocutaneous syndromes) Collagen tissue disorders (Lupus erythematosus, Wegener granulomatosis) |
Etiologic classification of orbital tumors causing secondary glaucoma.
IOP evaluation should be routinely performed when evaluating a case of suspected orbital tumor or pathology. Gonioscopic examination can provide essential information regarding the status of the anterior chamber angle as well as show evidence of blood in Schlemm’s canal as the distinguishing feature of elevated venous pressure. The treatment of primary orbital pathology along with medical management of raised IOP is indicated for control of orbital tumor related secondary glaucoma.
In sum, glaucoma can be associated with various ocular as well as orbital tumors. It may constitute one of the many manifesting clinical features or be the sole presenting feature of these pathologies. Appropriate diagnosis and timely management of these tumors can help eye and vision salvage; however, a misdiagnosis or delayed diagnosis due to initial presentation as secondary glaucoma can lead to catastrophic sequel necessitating enucleation and can pose a greater risk to life. A thorough clinical evaluation, use of ancillary testing and stepwise management can help achieve optimum visual outcome and overall survival in cases with ocular or orbital tumors.
The author acknowledges contributions from Dr. Paul T Finger MD, FACS, Director- The New York Eye Cancer Center, New York, USA and Dr. Santosh G Honavar MD, FACS, Director- Ocular Oncology Services, Centre For Sight Hospital, Hyderabad, India for select clinical images used in this chapter.
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All published Book Chapters are licensed under a Creative Commons Attribution 3.0 Unported License. Monographs are licensed under the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) license granted to all others. Our Copyright Policy aims to guarantee that original material is published while at the same time giving significant freedom to our Authors. IntechOpen upholds a flexible Copyright Policy meaning that there is no copyright transfer to the publisher and Authors hold exclusive copyright to their work.
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Therefore, there is a need to address these issues. The objective of the study was to ascertain the psychosocial and clinical features predicting suicide and NSSI in adolescents with major depression. Increased number of suicidality and impaired family function at entry is autonomously connected with a suicidal attempt. NSSI are connected at base line and apply additive effect on likelihood, one keeping on through treatment period. Poor family functions, as well as family problems and social problems, were the causative agents for adolescent’s high suicidality and NSSI. A history of NSSI treatment is a clinical marker for suicidality. The previous suicidal attempts should be evaluated in depressed juvenile patients as indicators of future suicidal intent and behavior. Both suicidal and NSSI adolescents during the therapy and after treatment endure to be depressed when they are engaged in study. Major causes of suicide among our study participants were lost friend(s), drug abuse, living alone, disturbed parental marriage, sexual abuse, and other domestic problems.",book:{id:"10910",slug:"learning-disabilities-neurobiology-assessment-clinical-features-and-treatments",title:"Learning Disabilities",fullTitle:"Learning Disabilities - Neurobiology, Assessment, Clinical Features and Treatments"},signatures:"Fahad Hassan Shah, Song Ja Kim, Laiba Zakir, Aqsa Ehsan, Sohail Riaz, Muhammad Sulaiman and Saad Salman",authors:[{id:"418086",title:"Dr.",name:"Saad",middleName:null,surname:"Salman",slug:"saad-salman",fullName:"Saad Salman"},{id:"439291",title:"Dr.",name:"Fahad Hassan",middleName:null,surname:"Shah",slug:"fahad-hassan-shah",fullName:"Fahad Hassan Shah"},{id:"439292",title:"Dr.",name:"Song Ja",middleName:null,surname:"Kim",slug:"song-ja-kim",fullName:"Song Ja Kim"},{id:"439293",title:"Dr.",name:"Laiba",middleName:null,surname:"Zakir",slug:"laiba-zakir",fullName:"Laiba Zakir"},{id:"439294",title:"Dr.",name:"Aqsa",middleName:null,surname:"Ehsan",slug:"aqsa-ehsan",fullName:"Aqsa Ehsan"},{id:"451112",title:"Dr.",name:"Sohail",middleName:null,surname:"Riaz",slug:"sohail-riaz",fullName:"Sohail Riaz"},{id:"451113",title:"Dr.",name:"Muhammad",middleName:null,surname:"Sulaiman",slug:"muhammad-sulaiman",fullName:"Muhammad Sulaiman"}]},{id:"79900",title:"Dyslexia, Dysgraphia and Dyscalculia: A Response to Intervention Approach to Classification",slug:"dyslexia-dysgraphia-and-dyscalculia-a-response-to-intervention-approach-to-classification",totalDownloads:165,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"This chapter provides a model for classification of dyslexia, dysgraphia and dyscalculia through analysis of the response of children to treatment. The model is discussed with reference to the types of multivariate treatment applied in a particular programme which works interactively online using an electronic data-base for linking functional difficulties in learning to treatment, and through this to firm diagnosis and classification. In applying the model, initial diagnosis of learning disabilities is treated as provisional, based on functional indicators as well as test data. Firm classification becomes possible through longitudinal assessment, analysis of response to multivariate intervention as well as response to specific programmes. Diagnosis can then be linked both to concessions as well as ongoing treatment.",book:{id:"10910",slug:"learning-disabilities-neurobiology-assessment-clinical-features-and-treatments",title:"Learning Disabilities",fullTitle:"Learning Disabilities - Neurobiology, Assessment, Clinical Features and Treatments"},signatures:"Charles Potter",authors:[{id:"93190",title:"Dr.",name:"Charles",middleName:null,surname:"Potter",slug:"charles-potter",fullName:"Charles Potter"}]},{id:"78359",title:"Self-Regulation, Self-Efficacy, and Learning Disabilities",slug:"self-regulation-self-efficacy-and-learning-disabilities",totalDownloads:298,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"This chapter will discuss the roles of self-regulation and self-efficacy in students with learning disabilities. The guiding conceptual framework is based in social cognitive theory. In this theory, self-efficacy is a key motivational variable and self-regulation is a means for persons to develop a sense of agency, or the belief that they can exert a large degree of control over outcomes in their lives. Following a description of the theory, research is presented showing the operation of self-regulation and self-efficacy in students with learning disabilities. Future research directions are suggested, and implications of theory and research for educational practice are discussed.",book:{id:"10910",slug:"learning-disabilities-neurobiology-assessment-clinical-features-and-treatments",title:"Learning Disabilities",fullTitle:"Learning Disabilities - Neurobiology, Assessment, Clinical Features and Treatments"},signatures:"Dale H. Schunk and Maria K. DiBenedetto",authors:[{id:"418379",title:"Prof.",name:"Dale H.",middleName:null,surname:"Schunk",slug:"dale-h.-schunk",fullName:"Dale H. Schunk"},{id:"418381",title:"Dr.",name:"Maria K.",middleName:null,surname:"DiBenedetto",slug:"maria-k.-dibenedetto",fullName:"Maria K. DiBenedetto"}]},{id:"31181",title:"Language Disabilities: Myths and Misconceptions vs. Reality",slug:"language-disabilities-myths-and-misconceptions-vs-reality",totalDownloads:3278,totalCrossrefCites:0,totalDimensionsCites:0,abstract:null,book:{id:"715",slug:"learning-disabilities",title:"Learning Disabilities",fullTitle:"Learning Disabilities"},signatures:"George S. 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He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. 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Dr. Bobek is a member of the editorial boards of six international journals and a member of the Strategic Council of the Minister of Foreign Affairs of the Republic of Slovenia. He has a long history in academia, consulting, and entrepreneurship. His own consulting firm, Palemid, has managed twenty significant projects, such as Cooperation Program Interreg V-A (Slovenia-Austria) and Capacity Building for the Serbian Chamber of Enforcement Agents. He has also participated in many international projects in Italy, Germany, Great Britain, the United States, Spain, Turkey, France, Romania, Croatia, Montenegro, Malaysia, and China. Dr. Bobek is also a co-founder of the Academy of Regional Management in Slovenia.",institutionString:"Universities of Applied Sciences FH Joanneum, Austria",institution:null},editorTwo:{id:"293992",title:"Dr.",name:"Tatjana",middleName:null,surname:"Horvat",slug:"tatjana-horvat",fullName:"Tatjana Horvat",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002hXb0hQAC/Profile_Picture_1642419002203",biography:"Tatjana Horvat works as a professor for accountant and auditing at the University of Primorska, Slovenia. She is a Certified State Internal Auditor (licensed by Ministry of Finance RS) and Certified Internal Auditor for Business Sector and Certified accountant (licensed by Slovenian Institute of Auditors). 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Dr. Ortiz has previously worked for international organizations and non-government entities in economic and business matters, and he has university-wide globalization engagement in more than thirty-six countries. He has advised, among others, the United Nations Development Program, Inter-American Development Bank, Organization of American States, Pre-investment Organization of Latin America and the Caribbean, Technical Cooperation of the Suisse Government, and the World Bank. Dr. Ortiz is the author, co-author, or editor of books, book chapters, textbooks, research monographs and technical reports, and refereed journal articles. He is listed in Who’s Who in the World, Who’s Who in America, Who’s Who in Finance and Business, Who’s Who in Business Higher Education, Who’s Who in American Education, and Who’s Who Directory of Economists. Dr. Ortiz has been a Fulbright Scholar and an MSI Leadership Fellow with the W.K. Kellogg Foundation. His teaching interests revolve around global economies and markets while his research focuses on topics related to development and growth, global business decisions, and the economics of technical innovation.",institutionString:null,institution:{name:"University of Houston",institutionURL:null,country:{name:"United States of America"}}},editorTwo:null,editorThree:null},{id:"88",title:"Marketing",coverUrl:"https://cdn.intechopen.com/series_topics/covers/88.jpg",isOpenForSubmission:!0,annualVolume:11972,editor:{id:"203609",title:"Associate Prof.",name:"Hanna",middleName:null,surname:"Gorska-Warsewicz",slug:"hanna-gorska-warsewicz",fullName:"Hanna Gorska-Warsewicz",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSD9pQAG/Profile_Picture_2022-06-14T11:58:32.jpeg",biography:"Hanna Górska-Warsewicz, Ph.D. is Associate Professor at Warsaw University of Life Sciences and Head of Department of Food Market and Consumption Research. She specializes in the subject of brands, brand equity, and brand management in production, service, and trade enterprises. She combines this subject with marketing and marketing management in both theoretical and practical aspects. Prof. Hanna Górska-Warsewicz also analyzes brands in the context of trademarks, legal regulations and the protection of intangible. She is an author or co-author of over 200 publications in this field, including 8 books. She works with the business sector and has participated in projects for the Ministry of Agriculture and Rural Development and the Ministry of Education and Science in Poland.",institutionString:null,institution:{name:"Warsaw University of Life Sciences",institutionURL:null,country:{name:"Poland"}}},editorTwo:null,editorThree:null}]},overviewPageOFChapters:{paginationCount:45,paginationItems:[{id:"82135",title:"Carotenoids in Cassava (Manihot esculenta Crantz)",doi:"10.5772/intechopen.105210",signatures:"Lovina I. Udoh, Josephine U. 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Serves as a peer reviewer for biomedical journals. Military Reserve Officer serving with the 100 Support Command, 100 Troop Command, 40 Infantry Division, CA National Guard.",institutionString:null,institution:{name:"Loma Linda University",institutionURL:null,country:{name:"United States of America"}}}]},{type:"book",id:"6925",title:"Endoplasmic Reticulum",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6925.jpg",slug:"endoplasmic-reticulum",publishedDate:"April 17th 2019",editedByType:"Edited by",bookSignature:"Angel Català",hash:"a9e90d2dbdbc46128dfe7dac9f87c6b4",volumeInSeries:2,fullTitle:"Endoplasmic Reticulum",editors:[{id:"196544",title:"Prof.",name:"Angel",middleName:null,surname:"Catala",slug:"angel-catala",fullName:"Angel Catala",profilePictureURL:"https://mts.intechopen.com/storage/users/196544/images/system/196544.jpg",biography:"Angel Catalá studied chemistry at Universidad Nacional de La Plata, Argentina, where he received a Ph.D. in Chemistry (Biological Branch) in 1965. From 1964 to 1974, he worked as an Assistant in Biochemistry at the School of Medicine at the same university. From 1974 to 1976, he was a fellow of the National Institutes of Health (NIH) at the University of Connecticut, Health Center, USA. From 1985 to 2004, he served as a Full Professor of Biochemistry at the Universidad Nacional de La Plata. He is a member of the National Research Council (CONICET), Argentina, and the Argentine Society for Biochemistry and Molecular Biology (SAIB). His laboratory has been interested for many years in the lipid peroxidation of biological membranes from various tissues and different species. Dr. Catalá has directed twelve doctoral theses, published more than 100 papers in peer-reviewed journals, several chapters in books, and edited twelve books. He received awards at the 40th International Conference Biochemistry of Lipids 1999 in Dijon, France. He is the winner of the Bimbo Pan-American Nutrition, Food Science and Technology Award 2006 and 2012, South America, Human Nutrition, Professional Category. In 2006, he won the Bernardo Houssay award in pharmacology, in recognition of his meritorious works of research. Dr. Catalá belongs to the editorial board of several journals including Journal of Lipids; International Review of Biophysical Chemistry; Frontiers in Membrane Physiology and Biophysics; World Journal of Experimental Medicine and Biochemistry Research International; World Journal of Biological Chemistry, Diabetes, and the Pancreas; International Journal of Chronic Diseases & Therapy; and International Journal of Nutrition. He is the co-editor of The Open Biology Journal and associate editor for Oxidative Medicine and Cellular Longevity.",institutionString:"Universidad Nacional de La Plata",institution:{name:"National University of La Plata",institutionURL:null,country:{name:"Argentina"}}}]},{type:"book",id:"6924",title:"Adenosine Triphosphate in Health and Disease",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6924.jpg",slug:"adenosine-triphosphate-in-health-and-disease",publishedDate:"April 24th 2019",editedByType:"Edited by",bookSignature:"Gyula Mozsik",hash:"04106c232a3c68fec07ba7cf00d2522d",volumeInSeries:3,fullTitle:"Adenosine Triphosphate in Health and Disease",editors:[{id:"58390",title:"Dr.",name:"Gyula",middleName:null,surname:"Mozsik",slug:"gyula-mozsik",fullName:"Gyula Mozsik",profilePictureURL:"https://mts.intechopen.com/storage/users/58390/images/system/58390.png",biography:"Gyula Mózsik MD, Ph.D., ScD (med), is an emeritus professor of Medicine at the First Department of Medicine, Univesity of Pécs, Hungary. He was head of this department from 1993 to 2003. His specializations are medicine, gastroenterology, clinical pharmacology, clinical nutrition, and dietetics. His research fields are biochemical pharmacological examinations in the human gastrointestinal (GI) mucosa, mechanisms of retinoids, drugs, capsaicin-sensitive afferent nerves, and innovative pharmacological, pharmaceutical, and nutritional (dietary) research in humans. He has published about 360 peer-reviewed papers, 197 book chapters, 692 abstracts, 19 monographs, and has edited 37 books. He has given about 1120 regular and review lectures. He has organized thirty-eight national and international congresses and symposia. He is the founder of the International Conference on Ulcer Research (ICUR); International Union of Pharmacology, Gastrointestinal Section (IUPHAR-GI); Brain-Gut Society symposiums, and gastrointestinal cytoprotective symposiums. He received the Andre Robert Award from IUPHAR-GI in 2014. 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He\nreceived a short-term scholarship to carry out his post-doctoral\nstudies abroad, from Japan International Cooperation Agency\n(JICA), in coordination with the Egyptian government. Dr.\nShalaby speaks fluent English and his native Arabic. He has 77\ninternationally published research papers, has attended 15 international conferences, and has contributed to 18 international books and chapters.\nDr. Shalaby works as a reviewer on over one hundred international journals and is\non the editorial board of more than twenty-five international journals. 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He worked as a post-doctoral fellow at the Public Health Research Institute (PHRI), Newark, NJ for four years before accepting a three-year faculty position at Brigham Young University-Hawaii. Dr. Engohang-Ndong is a tenured faculty member with the academic rank of Full Professor at Kent State University, Ohio, where he teaches a wide range of biological science courses and pursues his research in medical and environmental microbiology. 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He has an excellent track record in the herpesvirus field, and his group is engaged in clinical research in the field of Epstein-Barr virus diseases. He is the editor of the online Encyclopedia of Environment and he coordinates the Universal Health Coverage education program for the BioHealth Computing Schools of the European Institute of Science.",institutionString:null,institution:{name:"Grenoble Alpes University",country:{name:"France"}}},{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",biography:"Dr. Rodriguez-Morales is an expert in tropical and emerging diseases, particularly zoonotic and vector-borne diseases (especially arboviral diseases). He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},{id:"332819",title:"Dr.",name:"Chukwudi Michael",middleName:"Michael",surname:"Egbuche",slug:"chukwudi-michael-egbuche",fullName:"Chukwudi Michael Egbuche",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/332819/images/14624_n.jpg",biography:"I an Dr. Chukwudi Michael Egbuche. I am a Senior Lecturer in the Department of Parasitology and Entomology, Nnamdi Azikiwe University, Awka.",institutionString:null,institution:{name:"Nnamdi Azikiwe University",country:{name:"Nigeria"}}},{id:"284232",title:"Mr.",name:"Nikunj",middleName:"U",surname:"Tandel",slug:"nikunj-tandel",fullName:"Nikunj Tandel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/284232/images/8275_n.jpg",biography:'Mr. Nikunj Tandel has completed his Master\'s degree in Biotechnology from VIT University, India in the year of 2012. He is having 8 years of research experience especially in the field of malaria epidemiology, immunology, and nanoparticle-based drug delivery system against the infectious diseases, autoimmune disorders and cancer. He has worked for the NIH funded-International Center of Excellence in Malaria Research project "Center for the study of complex malaria in India (CSCMi)" in collaboration with New York University. The preliminary objectives of the study are to understand and develop the evidence-based tools and interventions for the control and prevention of malaria in different sites of the INDIA. Alongside, with the help of next-generation genomics study, the team has studied the antimalarial drug resistance in India. Further, he has extended his research in the development of Humanized mice for the study of liver-stage malaria and identification of molecular marker(s) for the Artemisinin resistance. At present, his research focuses on understanding the role of B cells in the activation of CD8+ T cells in malaria. 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She is currently an Adjunct Professor at Feevale University in Medicine and Biomedicine courses and a permanent professor of the Academic Master\\'s Degree in Virology. She has experience in the field of Microbiology, with an emphasis on Bacteriology, working mainly on the following topics: bacteriophages, bacterial resistance, clinical microbiology and food microbiology.",institutionString:null,institution:{name:"Universidade Feevale",country:{name:"Brazil"}}},{id:"229220",title:"Dr.",name:"Amjad",middleName:"Islam",surname:"Aqib",slug:"amjad-aqib",fullName:"Amjad Aqib",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229220/images/system/229220.png",biography:"Dr. Amjad Islam Aqib obtained a DVM and MSc (Hons) from University of Agriculture Faisalabad (UAF), Pakistan, and a PhD from the University of Veterinary and Animal Sciences Lahore, Pakistan. 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Professor Derbel is presently working at the Clinique les Oliviers, Sousse, Tunisia. His hospital activities are mostly concerned with laparoscopic, colorectal, pancreatic, hepatobiliary, and gastric surgery. He is also very interested in hernia surgery and performs ventral hernia repairs and inguinal hernia repairs. He has been a member of the GREPA and Tunisian Hernia Society (THS). During his residency, he managed patients suffering from diabetic foot, and he was very interested in this pathology. For this reason, he decided to coordinate a book project dealing with the diabetic foot. Professor Derbel has published many articles in journals and collaborates intensively with IntechOpen Access Publisher as an editor.",institutionString:"Clinique les Oliviers",institution:null},{id:"300144",title:"Dr.",name:"Meriem",middleName:null,surname:"Braiki",slug:"meriem-braiki",fullName:"Meriem Braiki",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/300144/images/system/300144.jpg",biography:"Dr. Meriem Braiki is a specialist in pediatric surgeon from Tunisia. She was born in 1985. She received her medical degree from the University of Medicine at Sousse, Tunisia. She achieved her surgical residency training periods in Pediatric Surgery departments at University Hospitals in Monastir, Tunis and France.\r\nShe is currently working at the Pediatric surgery department, Sidi Bouzid Hospital, Tunisia. Her hospital activities are mostly concerned with laparoscopic, parietal, urological and digestive surgery. She has published several articles in diffrent journals.",institutionString:"Sidi Bouzid Regional Hospital",institution:null},{id:"229481",title:"Dr.",name:"Erika M.",middleName:"Martins",surname:"de Carvalho",slug:"erika-m.-de-carvalho",fullName:"Erika M. de Carvalho",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229481/images/6397_n.jpg",biography:null,institutionString:null,institution:{name:"Oswaldo Cruz Foundation",country:{name:"Brazil"}}},{id:"186537",title:"Prof.",name:"Tonay",middleName:null,surname:"Inceboz",slug:"tonay-inceboz",fullName:"Tonay Inceboz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/186537/images/system/186537.jfif",biography:"I was graduated from Ege University of Medical Faculty (Turkey) in 1988 and completed his Med. PhD degree in Medical Parasitology at the same university. I became an Associate Professor in 2008 and Professor in 2014. I am currently working as a Professor at the Department of Medical Parasitology at Dokuz Eylul University, Izmir, Turkey.\n\nI have given many lectures, presentations in different academic meetings. I have more than 60 articles in peer-reviewed journals, 18 book chapters, 1 book editorship.\n\nMy research interests are Echinococcus granulosus, Echinococcus multilocularis (diagnosis, life cycle, in vitro and in vivo cultivation), and Trichomonas vaginalis (diagnosis, PCR, and in vitro cultivation).",institutionString:"Dokuz Eylül University",institution:{name:"Dokuz Eylül University",country:{name:"Turkey"}}},{id:"71812",title:"Prof.",name:"Hanem Fathy",middleName:"Fathy",surname:"Khater",slug:"hanem-fathy-khater",fullName:"Hanem Fathy Khater",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/71812/images/1167_n.jpg",biography:"Prof. Khater is a Professor of Parasitology at Benha University, Egypt. She studied for her doctoral degree, at the Department of Entomology, College of Agriculture, Food and Natural Resources, University of Missouri, Columbia, USA. She has completed her Ph.D. degrees in Parasitology in Egypt, from where she got the award for “the best scientific Ph.D. dissertation”. She worked at the School of Biological Sciences, Bristol, England, the UK in controlling insects of medical and veterinary importance as a grant from Newton Mosharafa, the British Council. Her research is focused on searching of pesticides against mosquitoes, house flies, lice, green bottle fly, camel nasal botfly, soft and hard ticks, mites, and the diamondback moth as well as control of several parasites using safe and natural materials to avoid drug resistances and environmental contamination.",institutionString:null,institution:{name:"Banha University",country:{name:"Egypt"}}},{id:"99780",title:"Prof.",name:"Omolade",middleName:"Olayinka",surname:"Okwa",slug:"omolade-okwa",fullName:"Omolade Okwa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/99780/images/system/99780.jpg",biography:"Omolade Olayinka Okwa is presently a Professor of Parasitology at Lagos State University, Nigeria. She has a PhD in Parasitology (1997), an MSc in Cellular Parasitology (1992), and a BSc (Hons) Zoology (1990) all from the University of Ibadan, Nigeria. She teaches parasitology at the undergraduate and postgraduate levels. She was a recipient of a Commonwealth fellowship supported by British Council tenable at the Centre for Entomology and Parasitology (CAEP), Keele University, United Kingdom between 2004 and 2005. She was awarded an Honorary Visiting Research Fellow at the same university from 2005 to 2007. \nShe has been an external examiner to the Department of Veterinary Microbiology and Parasitology, University of Ibadan, MSc programme between 2010 and 2012. She is a member of the Nigerian Society of Experimental Biology (NISEB), Parasitology and Public Health Society of Nigeria (PPSN), Science Association of Nigeria (SAN), Zoological Society of Nigeria (ZSN), and is Vice Chairperson of the Organisation of Women in Science (OWSG), LASU chapter. She served as Head of Department of Zoology and Environmental Biology, Lagos State University from 2007 to 2010 and 2014 to 2016. She is a reviewer for several local and international journals such as Unilag Journal of Science, Libyan Journal of Medicine, Journal of Medicine and Medical Sciences, and Annual Research and Review in Science. \nShe has authored 45 scientific research publications in local and international journals, 8 scientific reviews, 4 books, and 3 book chapters, which includes the books “Malaria Parasites” and “Malaria” which are IntechOpen access publications.",institutionString:"Lagos State University",institution:{name:"Lagos State University",country:{name:"Nigeria"}}},{id:"273100",title:"Dr.",name:"Vijay",middleName:null,surname:"Gayam",slug:"vijay-gayam",fullName:"Vijay Gayam",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/273100/images/system/273100.jpeg",biography:"Dr. Vijay Bhaskar Reddy Gayam is currently practicing as an internist at Interfaith Medical Center in Brooklyn, New York, USA. He is also a Clinical Assistant Professor at the SUNY Downstate University Hospital and Adjunct Professor of Medicine at the American University of Antigua. He is a holder of an M.B.B.S. degree bestowed to him by Osmania Medical College and received his M.D. at Interfaith Medical Center. His career goals thus far have heavily focused on direct patient care, medical education, and clinical research. He currently serves in two leadership capacities; Assistant Program Director of Medicine at Interfaith Medical Center and as a Councilor for the American\r\nFederation for Medical Research. As a true academician and researcher, he has more than 50 papers indexed in international peer-reviewed journals. He has also presented numerous papers in multiple national and international scientific conferences. His areas of research interest include general internal medicine, gastroenterology and hepatology. He serves as an editor, editorial board member and reviewer for multiple international journals. His research on Hepatitis C has been very successful and has led to multiple research awards, including the 'Equity in Prevention and Treatment Award” from the New York Department of Health Viral Hepatitis Symposium (2018) and the 'Presidential Poster Award” awarded to him by the American College of Gastroenterology (2018). He was also awarded 'Outstanding Clinician in General Medicine” by Venus International Foundation for his extensive research expertise and services, perform over and above the standard expected in the advancement of healthcare, patient safety and quality of care.",institutionString:"Interfaith Medical Center",institution:{name:"Interfaith Medical Center",country:{name:"United States of America"}}},{id:"93517",title:"Dr.",name:"Clement",middleName:"Adebajo",surname:"Meseko",slug:"clement-meseko",fullName:"Clement Meseko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/93517/images/system/93517.jpg",biography:"Dr. Clement Meseko obtained DVM and PhD degree in Veterinary Medicine and Virology respectively. He has worked for over 20 years in both private and public sectors including the academia, contributing to knowledge and control of infectious disease. Through the application of epidemiological skill, classical and molecular virological skills, he investigates viruses of economic and public health importance for the mitigation of the negative impact on people, animal and the environment in the context of Onehealth. \r\nDr. Meseko’s field experience on animal and zoonotic diseases and pathogen dynamics at the human-animal interface over the years shaped his carrier in research and scientific inquiries. He has been part of the investigation of Highly Pathogenic Avian Influenza incursions in sub Saharan Africa and monitors swine Influenza (Pandemic influenza Virus) agro-ecology and potential for interspecies transmission. He has authored and reviewed a number of journal articles and book chapters.",institutionString:"National Veterinary Research Institute",institution:{name:"National Veterinary Research Institute",country:{name:"Nigeria"}}},{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",country:{name:"India"}}},{id:"94928",title:"Dr.",name:"Takuo",middleName:null,surname:"Mizukami",slug:"takuo-mizukami",fullName:"Takuo Mizukami",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94928/images/6402_n.jpg",biography:null,institutionString:null,institution:{name:"National Institute of Infectious Diseases",country:{name:"Japan"}}},{id:"233433",title:"Dr.",name:"Yulia",middleName:null,surname:"Desheva",slug:"yulia-desheva",fullName:"Yulia Desheva",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/233433/images/system/233433.png",biography:"Dr. Yulia Desheva is a leading researcher at the Institute of Experimental Medicine, St. Petersburg, Russia. She is a professor in the Stomatology Faculty, St. Petersburg State University. She has expertise in the development and evaluation of a wide range of live mucosal vaccines against influenza and bacterial complications. Her research interests include immunity against influenza and COVID-19 and the development of immunization schemes for high-risk individuals.",institutionString:'Federal State Budgetary Scientific Institution "Institute of Experimental Medicine"',institution:null},{id:"238958",title:"Mr.",name:"Atamjit",middleName:null,surname:"Singh",slug:"atamjit-singh",fullName:"Atamjit Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/238958/images/6575_n.jpg",biography:null,institutionString:null,institution:null},{id:"333753",title:"Dr.",name:"Rais",middleName:null,surname:"Ahmed",slug:"rais-ahmed",fullName:"Rais Ahmed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/333753/images/20168_n.jpg",biography:null,institutionString:null,institution:null},{id:"252058",title:"M.Sc.",name:"Juan",middleName:null,surname:"Sulca",slug:"juan-sulca",fullName:"Juan Sulca",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252058/images/12834_n.jpg",biography:null,institutionString:null,institution:null},{id:"191392",title:"Dr.",name:"Marimuthu",middleName:null,surname:"Govindarajan",slug:"marimuthu-govindarajan",fullName:"Marimuthu Govindarajan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/191392/images/5828_n.jpg",biography:"Dr. M. Govindarajan completed his BSc degree in Zoology at Government Arts College (Autonomous), Kumbakonam, and MSc, MPhil, and PhD degrees at Annamalai University, Annamalai Nagar, Tamil Nadu, India. He is serving as an assistant professor at the Department of Zoology, Annamalai University. His research interests include isolation, identification, and characterization of biologically active molecules from plants and microbes. He has identified more than 20 pure compounds with high mosquitocidal activity and also conducted high-quality research on photochemistry and nanosynthesis. He has published more than 150 studies in journals with impact factor and 2 books in Lambert Academic Publishing, Germany. He serves as an editorial board member in various national and international scientific journals.",institutionString:null,institution:null},{id:"274660",title:"Dr.",name:"Damodar",middleName:null,surname:"Paudel",slug:"damodar-paudel",fullName:"Damodar Paudel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/274660/images/8176_n.jpg",biography:"I am DrDamodar Paudel,currently working as consultant Physician in Nepal police Hospital.",institutionString:null,institution:null},{id:"241562",title:"Dr.",name:"Melvin",middleName:null,surname:"Sanicas",slug:"melvin-sanicas",fullName:"Melvin Sanicas",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/241562/images/6699_n.jpg",biography:null,institutionString:null,institution:null},{id:"337446",title:"Dr.",name:"Maria",middleName:null,surname:"Zavala-Colon",slug:"maria-zavala-colon",fullName:"Maria Zavala-Colon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Puerto Rico, Medical Sciences Campus",country:{name:"United States of America"}}},{id:"338856",title:"Mrs.",name:"Nur Alvira",middleName:null,surname:"Pascawati",slug:"nur-alvira-pascawati",fullName:"Nur Alvira Pascawati",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universitas Respati Yogyakarta",country:{name:"Indonesia"}}},{id:"441116",title:"Dr.",name:"Jovanka M.",middleName:null,surname:"Voyich",slug:"jovanka-m.-voyich",fullName:"Jovanka M. Voyich",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Montana State University",country:{name:"United States of America"}}},{id:"330412",title:"Dr.",name:"Muhammad",middleName:null,surname:"Farhab",slug:"muhammad-farhab",fullName:"Muhammad Farhab",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Agriculture Faisalabad",country:{name:"Pakistan"}}},{id:"349495",title:"Dr.",name:"Muhammad",middleName:null,surname:"Ijaz",slug:"muhammad-ijaz",fullName:"Muhammad Ijaz",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Veterinary and Animal Sciences",country:{name:"Pakistan"}}}]}},subseries:{item:{id:"38",type:"subseries",title:"Pollution",keywords:"Human activity, Pollutants, Reduced risks, Population growth, Waste disposal, Remediation, Clean environment",scope:"
\r\n\tPollution is caused by a wide variety of human activities and occurs in diverse forms, for example biological, chemical, et cetera. In recent years, significant efforts have been made to ensure that the environment is clean, that rigorous rules are implemented, and old laws are updated to reduce the risks towards humans and ecosystems. However, rapid industrialization and the need for more cultivable sources or habitable lands, for an increasing population, as well as fewer alternatives for waste disposal, make the pollution control tasks more challenging. Therefore, this topic will focus on assessing and managing environmental pollution. It will cover various subjects, including risk assessment due to the pollution of ecosystems, transport and fate of pollutants, restoration or remediation of polluted matrices, and efforts towards sustainable solutions to minimize environmental pollution.
",coverUrl:"https://cdn.intechopen.com/series_topics/covers/38.jpg",hasOnlineFirst:!1,hasPublishedBooks:!0,annualVolume:11966,editor:{id:"110740",title:"Dr.",name:"Ismail M.M.",middleName:null,surname:"Rahman",slug:"ismail-m.m.-rahman",fullName:"Ismail M.M. Rahman",profilePictureURL:"https://mts.intechopen.com/storage/users/110740/images/2319_n.jpg",biography:"Ismail Md. Mofizur Rahman (Ismail M. M. Rahman) assumed his current responsibilities as an Associate Professor at the Institute of Environmental Radioactivity, Fukushima University, Japan, in Oct 2015. He also has an honorary appointment to serve as a Collaborative Professor at Kanazawa University, Japan, from Mar 2015 to the present. \nFormerly, Dr. Rahman was a faculty member of the University of Chittagong, Bangladesh, affiliated with the Department of Chemistry (Oct 2002 to Mar 2012) and the Department of Applied Chemistry and Chemical Engineering (Mar 2012 to Sep 2015). Dr. Rahman was also adjunctly attached with Kanazawa University, Japan (Visiting Research Professor, Dec 2014 to Mar 2015; JSPS Postdoctoral Research Fellow, Apr 2012 to Mar 2014), and Tokyo Institute of Technology, Japan (TokyoTech-UNESCO Research Fellow, Oct 2004–Sep 2005). \nHe received his Ph.D. degree in Environmental Analytical Chemistry from Kanazawa University, Japan (2011). He also achieved a Diploma in Environment from the Tokyo Institute of Technology, Japan (2005). Besides, he has an M.Sc. degree in Applied Chemistry and a B.Sc. degree in Chemistry, all from the University of Chittagong, Bangladesh. \nDr. Rahman’s research interest includes the study of the fate and behavior of environmental pollutants in the biosphere; design of low energy and low burden environmental improvement (remediation) technology; implementation of sustainable waste management practices for treatment, handling, reuse, and ultimate residual disposition of solid wastes; nature and type of interactions in organic liquid mixtures for process engineering design applications.",institutionString:null,institution:{name:"Fukushima University",institutionURL:null,country:{name:"Japan"}}},editorTwo:{id:"201020",title:"Dr.",name:"Zinnat Ara",middleName:null,surname:"Begum",slug:"zinnat-ara-begum",fullName:"Zinnat Ara Begum",profilePictureURL:"https://mts.intechopen.com/storage/users/201020/images/system/201020.jpeg",biography:"Zinnat A. Begum received her Ph.D. in Environmental Analytical Chemistry from Kanazawa University in 2012. She achieved her Master of Science (M.Sc.) degree with a major in Applied Chemistry and a Bachelor of Science (B.Sc.) in Chemistry, all from the University of Chittagong, Bangladesh. Her work affiliations include Fukushima University, Japan (Visiting Research Fellow, Institute of Environmental Radioactivity: Mar 2016 to present), Southern University Bangladesh (Assistant Professor, Department of Civil Engineering: Jan 2015 to present), and Kanazawa University, Japan (Postdoctoral Fellow, Institute of Science and Engineering: Oct 2012 to Mar 2014; Research fellow, Venture Business Laboratory, Advanced Science and Social Co-Creation Promotion Organization: Apr 2018 to Mar 2021). The research focus of Dr. Zinnat includes the effect of the relative stability of metal-chelator complexes in the environmental remediation process designs and the development of eco-friendly soil washing techniques using biodegradable chelators.",institutionString:null,institution:{name:"Fukushima University",institutionURL:null,country:{name:"Japan"}}},editorThree:null,series:{id:"25",title:"Environmental Sciences",doi:"10.5772/intechopen.100362",issn:"2754-6713"},editorialBoard:[{id:"252368",title:"Dr.",name:"Meng-Chuan",middleName:null,surname:"Ong",slug:"meng-chuan-ong",fullName:"Meng-Chuan Ong",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRVotQAG/Profile_Picture_2022-05-20T12:04:28.jpg",institutionString:null,institution:{name:"Universiti Malaysia Terengganu",institutionURL:null,country:{name:"Malaysia"}}},{id:"63465",title:"Prof.",name:"Mohamed Nageeb",middleName:null,surname:"Rashed",slug:"mohamed-nageeb-rashed",fullName:"Mohamed Nageeb Rashed",profilePictureURL:"https://mts.intechopen.com/storage/users/63465/images/system/63465.gif",institutionString:null,institution:{name:"Aswan University",institutionURL:null,country:{name:"Egypt"}}},{id:"187907",title:"Dr.",name:"Olga",middleName:null,surname:"Anne",slug:"olga-anne",fullName:"Olga Anne",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSBE5QAO/Profile_Picture_2022-04-07T09:42:13.png",institutionString:null,institution:{name:"Klaipeda State University of Applied Sciences",institutionURL:null,country:{name:"Lithuania"}}}]},onlineFirstChapters:{paginationCount:6,paginationItems:[{id:"82135",title:"Carotenoids in Cassava (Manihot esculenta Crantz)",doi:"10.5772/intechopen.105210",signatures:"Lovina I. 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