Indian UGS typology.
\r\n\t
",isbn:"978-1-80355-382-5",printIsbn:"978-1-80355-381-8",pdfIsbn:"978-1-80355-383-2",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!1,isSalesforceBook:!1,hash:"3066dd3ff29e1fac072fd60b08d4d3e7",bookSignature:"Dr. Zhengchao Wang",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11085.jpg",keywords:"Follicle Stimulating Hormone, Luteinizing Hormone, Follicular Development, Ovulatory Failure, Hypoxia-Inducible F1, Non-coding RNA, Insulin Receptor Substrate, Reproductive Hormone, Polycystic Ovary, Follicular Fluid, Granulosa Cells, PCOS",numberOfDownloads:385,numberOfWosCitations:0,numberOfCrossrefCitations:0,numberOfDimensionsCitations:0,numberOfTotalCitations:0,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"September 7th 2021",dateEndSecondStepPublish:"October 5th 2021",dateEndThirdStepPublish:"December 4th 2021",dateEndFourthStepPublish:"February 22nd 2022",dateEndFifthStepPublish:"April 23rd 2022",remainingDaysToSecondStep:"7 months",secondStepPassed:!0,currentStepOfPublishingProcess:5,editedByType:null,kuFlag:!1,biosketch:"Dr. Zhengchao Wang is a Principal Investigator for the General Program (National Natural Science Foundation of China) He is also a team leader in the Fujian Provincial Key Laboratory for Developmental Biology and Neurosciences. Dr. Wang is a senior member of the China Physiological Society, China Zoological Society, and China Maternal and Child Health Association.",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"204883",title:"Dr.",name:"Zhengchao",middleName:null,surname:"Wang",slug:"zhengchao-wang",fullName:"Zhengchao Wang",profilePictureURL:"https://mts.intechopen.com/storage/users/204883/images/system/204883.jpeg",biography:"Dr. Zhengchao Wang is a full professor at the College of Life Sciences, Fujian Normal University, China. He is a Principal Investigator for the General Program for the National Natural Science Foundation of China and Program for New Century Excellent Talents in the University of Ministry of Education of China. He is also a team leader in the Fujian Provincial Key Laboratory for Developmental Biology and Neurosciences, Key Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education. He obtained his Ph.D. in 2008 and has a long teaching and research career. He has published 172 scientific papers in English or Chinese, participated in approximately 32 grants, and published 12 books as the editor in his specialty and related diseases.",institutionString:"Fujian Normal University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"3",totalChapterViews:"0",totalEditedBooks:"2",institution:{name:"Fujian Normal University",institutionURL:null,country:{name:"China"}}}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"16",title:"Medicine",slug:"medicine"}],chapters:[{id:"80036",title:"Polycystic Ovary Syndrome Phenotypes and Infertility Treatment",slug:"polycystic-ovary-syndrome-phenotypes-and-infertility-treatment",totalDownloads:57,totalCrossrefCites:0,authors:[null]},{id:"80918",title:"Polycystic Ovary Syndrome: It’s Not Just Infertility",slug:"polycystic-ovary-syndrome-it-s-not-just-infertility",totalDownloads:30,totalCrossrefCites:0,authors:[null]},{id:"80385",title:"Thyroid Dysfunction: In Connection with PCOS",slug:"thyroid-dysfunction-in-connection-with-pcos",totalDownloads:39,totalCrossrefCites:0,authors:[null]},{id:"80033",title:"Novel Methods in the Diagnosis of PCOS: The Role of 3D Ultrasonographic Modalities",slug:"novel-methods-in-the-diagnosis-of-pcos-the-role-of-3d-ultrasonographic-modalities",totalDownloads:50,totalCrossrefCites:0,authors:[null]},{id:"79975",title:"Rare and Underappreciated Causes of Polycystic Ovarian Syndrome",slug:"rare-and-underappreciated-causes-of-polycystic-ovarian-syndrome",totalDownloads:88,totalCrossrefCites:0,authors:[null]},{id:"79950",title:"Pathophysiology of Poly Cystic Ovarian Syndrome",slug:"pathophysiology-of-poly-cystic-ovarian-syndrome",totalDownloads:121,totalCrossrefCites:0,authors:[null]}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"429339",firstName:"Jelena",lastName:"Vrdoljak",middleName:null,title:"Ms.",imageUrl:"https://mts.intechopen.com/storage/users/429339/images/20012_n.jpg",email:"jelena.v@intechopen.com",biography:"As an Author Service Manager, my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact."}},relatedBooks:[{type:"book",id:"9165",title:"Polycystic Ovarian Syndrome",subtitle:null,isOpenForSubmission:!1,hash:"0b802d11709666bd2574b2bb487c8376",slug:"polycystic-ovarian-syndrome",bookSignature:"Zhengchao Wang",coverURL:"https://cdn.intechopen.com/books/images_new/9165.jpg",editedByType:"Edited by",editors:[{id:"204883",title:"Dr.",name:"Zhengchao",surname:"Wang",slug:"zhengchao-wang",fullName:"Zhengchao Wang"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10571",title:"Global Women's Health",subtitle:null,isOpenForSubmission:!1,hash:"a6e4958a3dcb6623d2b8035bad5f3276",slug:"global-women-s-health",bookSignature:"Zhengchao Wang",coverURL:"https://cdn.intechopen.com/books/images_new/10571.jpg",editedByType:"Edited by",editors:[{id:"204883",title:"Dr.",name:"Zhengchao",surname:"Wang",slug:"zhengchao-wang",fullName:"Zhengchao Wang"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6550",title:"Cohort Studies in Health Sciences",subtitle:null,isOpenForSubmission:!1,hash:"01df5aba4fff1a84b37a2fdafa809660",slug:"cohort-studies-in-health-sciences",bookSignature:"R. Mauricio Barría",coverURL:"https://cdn.intechopen.com/books/images_new/6550.jpg",editedByType:"Edited by",editors:[{id:"88861",title:"Dr.",name:"R. Mauricio",surname:"Barría",slug:"r.-mauricio-barria",fullName:"R. Mauricio Barría"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9500",title:"Recent Advances in Bone Tumours and Osteoarthritis",subtitle:null,isOpenForSubmission:!1,hash:"ea4ec0d6ee01b88e264178886e3210ed",slug:"recent-advances-in-bone-tumours-and-osteoarthritis",bookSignature:"Hiran Amarasekera",coverURL:"https://cdn.intechopen.com/books/images_new/9500.jpg",editedByType:"Edited by",editors:[{id:"67634",title:"Dr.",name:"Hiran",surname:"Amarasekera",slug:"hiran-amarasekera",fullName:"Hiran Amarasekera"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"72",title:"Ionic Liquids",subtitle:"Theory, Properties, New Approaches",isOpenForSubmission:!1,hash:"d94ffa3cfa10505e3b1d676d46fcd3f5",slug:"ionic-liquids-theory-properties-new-approaches",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/72.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2270",title:"Fourier Transform",subtitle:"Materials Analysis",isOpenForSubmission:!1,hash:"5e094b066da527193e878e160b4772af",slug:"fourier-transform-materials-analysis",bookSignature:"Salih Mohammed Salih",coverURL:"https://cdn.intechopen.com/books/images_new/2270.jpg",editedByType:"Edited by",editors:[{id:"111691",title:"Dr.Ing.",name:"Salih",surname:"Salih",slug:"salih-salih",fullName:"Salih Salih"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"57073",title:"Photodynamic Therapy and Skin Cancer",doi:"10.5772/intechopen.70309",slug:"photodynamic-therapy-and-skin-cancer",body:'Non-melanoma skin cancer (NMSC) is the most common type of cancer among white-skin individuals worldwide with an increasing incidence over the last years. Clinical examination, evaluation through dermoscopy and histopathology are the gold standard methods for the diagnosis of skin cancer. These diagnostic procedures together with the location and extent of the tumor will determine the choice of treatment. NMSC is mostly treated with surgical excision or non-invasive methods such as cryotherapy, application of topical chemotherapeutics or radiotherapy. However, limitations and side-effects of the conventional therapies motivate the development of other techniques.
Over the last years, there has been a rapidly growing interest in the use of photodynamic therapy (PDT) for treatment and prevention of skin cancer. PDT is a well-tolerated, safe and effective alternative in the treatment and prevention of non-melanoma skin cancer. Nowadays, it is mostly used for the treatment for actinic keratosis but also for in situ squamous cell carcinoma (Bowen’s disease), superficial- and also nodular basal cell carcinoma with acceptable response rates [1].
As a non-invasive targeted therapy with a low spectrum of adverse effects, PDT has advantages concerning the patient comfort and achieves excellent cosmetic results while the response rates are comparable to that of other surgical and nonsurgical procedures [2].
The aim of this chapter is to provide an assessment of the current state of use of PDT in the treatment of skin cancer and focus on new developments and future aspects of this procedure in the treatment of non-melanoma skin cancer.
The main principle of photodynamic therapy is based on photooxidation occurring in a target tissue. Key components of this technique are a photosensitizer, oxygen and light within the absorption spectrum of the photosensitizer.
The mechanism of action of photosensitizers is divided in two different types. Type I reaction involves direct oxidation by hydrogen peroxide, superoxide anion radical and hydroxyl radical of biological targets (DNA, membranes and proteins), while type II reaction includes oxidation mediated by singlet oxygen through energy transfer from triplet states to molecular oxygen [3]. The production of reactive oxygen species (ROS) depends on the uptake of a photosensitizing drug by the tumor, the subsequent irradiation of the tumor with visible light of an appropriate wavelength and the presence of an adequate concentration of molecular oxygen [3]. A photosensitizer can induce tissue damage either directly through induction of necrosis or apoptosis or indirectly by affecting its vascularization. It is important to know that in absence of any one of these components, the effectiveness of photodynamic response is disturbed. Therefore, careful selection of photosensitizer, type of tissue photosensitization and light dosimetry is essential [4, 5].
Photosensitizers (PSs) are substances capable of making an organism, a cell or a tissue photosensitive by inducing the photo-oxidation of several types of molecules through energy transfer processes. The development of an ideal photosensitizer remains a major challenge since several characteristics have to be taken into consideration. It is important for the photosensitizer to be chemically pure, to have chemical and physical stability, high selectivity and to be activated only in the presence of light, with no dark toxicity. The wavelength of the light used in PDT has to be longer than those in the UV spectrum in order to minimize the risk of UV-induced skin cancer. Its absorption peak should be a wavelength > 630 nm, where it presents an optimal tissue penetration. Furthermore, it should have a high absorption capacity being able to be rapidly and predominantly retained in the tumor tissue and eliminated from the organism in order to prevent the risk of prolonged systemic photosensitivity. The photosensitizer should also have a clearance from the tumor tissue which is slower than that of normal cells and be capable to generate reactive oxygen species [6].
For dermatological appliance, only haematoporphyrin derivatives like porfimer sodium (Photofrin H) or protoporphyrin IX (PPIX)-inducing precursors like 5-aminolevulinic acid (ALA) or methyl aminolevulinate (MAL) are of practical concern. Therefore topical photosensitizers are preferred for use in dermatology. After topical application, both ALA and MAL are mainly taken up by cells of epithelial origin and are converted into photosensitizing porphyrins [7]. After an incubation period, followed by illumination with visible light to activate the photosensitizer a type II photo-oxidation reaction takes place and produces reactive oxygen species (ROS), which destroy cell membranes and structures, ultimately leading to cell death. The appropriate wavelength of light, concentration of sensitizer and molecular oxygen level in the tissue are all critical for the efficacy of PDT [8].
Current clinical practice utilizes the use of topical photosensitizers in PDT such as 5-aminolevulinic acid (5-ALA) or methyl-aminolevulinate (MAL), which are both precursors in the biosynthesis of protoporphyrin IX (PpIX) (Figure 1). PpIX is a native photosensitizing compound that accumulates in the cells and has an absorption peak at 505, 540, 580 and 630 nm.
Molecular structures of 5-aminolevulinic acid (5-ALA) and methyl-aminolevulinate (MAL).
The 5-ALA-based photosensitizers are not photoactive themselves, but show a preferential intracellular accumulation in the tissue target and particularly in the tumor cells where they are metabolized by the haem biosynthesis into photosensitizing porphyrins [7, 9].
Although these two molecules share a similar mechanism of action as prodrugs that lead to production of photoactive PpIX, they have notable differences.
ALA is a hydrophilic molecule and is used to treat more superficial lesions due to its modest tissue penetration [10]. Although the uptake of ALA is non-selective, accumulation of PpIX in tumor cells may occur selectively through alterations in enzymatic activity in the heme synthesis pathway. It is supposed, that activity of porphobilinogen deaminase (PBGD) increases in tumor tissue. PBGD synthesizes a precursor of PpIX and thus increases production of PpIX. The accumulation of PpIX in tumor tissue is further enhanced by decreased activity of ferrochelatase, which converts PpIX to heme [11]. Another postulated mechanism of selectivity for topical ALA relates to the altered stratum corneum of tumoral skin.
MAL is a more hydrophobic molecule which can better penetrate through the cell membranes and more easily reaches the deepest epidermal layers. Therefore, shows MAL a higher selectivity for tumor cells compared with ALA. However, the biosynthesis of protoporphyrin IX production from MAL is slightly slower because of the need of hydrolysis of this compound. Adjacent unaffected structures such as epidermis and mesenchymal cells show a much less pronounced production of porphyrin, thus leading to a high ratio between tumor and surrounding tissue [12]. This technique enables a selective detection (fluorescence detection) and selective destruction of the target tissue with minimal harm to the surrounding one (Figure 2).
Selective detection of fluorescence due to prior application of ALA on a superficial BBC lesion.
Interestingly, there seems to be no significant differences in the efficacy between ALA- and MAL-PDT in the treatment of NMSC, as recently shown [13].
Standardized protocols for the application of both photosensitizing drugs have been developed. For MAL-PDT, there is a standardized protocol of two treatments 1 week apart for basal cell carcinoma (BCC) and Bowen’s disease (BD), but with only one initial treatment for actinic keratosis (AK), repeated at 3 months, only if required [1]. MAL is typically applied for 3 h, but Levulan ALA although licensed for an 18–24 h application, is widely used with shorter application intervals around 1 h [14]. A shorter incubation for MAL-PDT for 1 h in AK can also be performed since no significant difference in clearance rates have been reported [15].
Several novel topical photosensitizers such near-infrared (NIR) bacteriochlorin analogues [16], silicon phthalocyanine, alone [17] or in combination with C6-pyridinium ceramide (LCL29) [18] have promising characteristics for use in PDT but they are still in experimental level.
Distinct light sources can be used for PDT. For therapy, the tissue must be irradiated with light at appropriate wavelengths (within the absorption spectrum of porphyrins) and the light source should have special characteristics for use in PDT in NMSC. Light should be perfectly absorbed by the photosensitizer, achieve a desirable penetration depth and thus reaching the target tissue, have an adequate power and duration in order to trigger the PDT reaction and cause minimal discomfort or side-effects such as erythema, crusting or dyspigmentation [19].
Porphyrins exhibit a very typical absorption spectrum with the highest peak at approximately 405 nm, called the Soret-band. Several so-called Q-bands also exist, the last having an absorption peak at 635 nm. Although the peak is much smaller than that at 405 nm, this wavelength is preferentially used for illumination since light at red spectrum results in a higher tissue penetration [20, 21].
The light sources available for PDT belong to three major groups: broad spectrum lamps, diode lamps and lasers. For a successful PDT-treatment using ALA- or MAL-PDT both laser and incoherent light sources can be used and there is no difference regarding the profile of light. Even pulsed laser light sources matching one of the Q-bands at 585 nm have comparable results to an incoherent light source in the treatment of AK [22]. Also the use of a long-pulsed dye laser at 595 nm seems to be effective for the same indication [19]. The incoherent light sources include the halogen lamps, the light-emitting diode (LED) lamps and intense pulsed light (IPL) lamps. Due to the possibility of distinct emission geometries and lower costs are an attractive option [23, 24].
Light with wavelengths of 635 nm is capable of penetrating the skin to a depth of approximately 6 mm compared to 1–2 mm with a wavelength of 400–500 nm. The effective therapeutic depth, however, appears to be close to 1–3 mm when 635 nm is used. This is due to the capacity to produce a photodynamic reaction, which depends on the dose of light and also on the quantity of photosensitizer used in the target tissue [25].
Advantages of lasers are that they provide a specific wavelength that corresponds to the peak absorption of the photosensitizer. Since lasers can emit high flux monochromatic light and have a focal precision, enable the treatment of small lesions with minimal damage to the surrounding tissue and within a short time interval. Nevertheless, for the treatment of dermatological conditions using PDT, lasers show no advantage compared to over cheaper and more practical options with non-coherent light sources. These sources emit a large radiation field, enabling larger areas of the skin surface to be treated [26]. However, the costs for purchasing and maintenance of these laser systems are extremely high. The gold standards in topical PDT are light sources with wide illumination fields which accomplish the simultaneous illumination of larger areas.
Here incoherent light sources are preferred, either lamps or light-emitting diodes (LEDs) which match the absorption maxima of the ALA- or MAL-induced porphyrins [25, 27, 28]. Using broad-spectrum red light (580–700 nm), a light dose of 100–150 J/cm2 (100–200 mW/cm2) is essential for tissue damage. The light intensity should not exceed 200 mW/cm2 in order to avoid hyperthermic side effects [27]. After a photosensitizer has been activated with light of appropriate wavelength, it comes to the generation of reactive oxygen species (ROS), in particular singlet oxygen. Depending on the extend and localization of the target tissue, these ROS modify either cellular functions or induce cell death by necrosis or apoptosis [29].
MAL-PDT using daylight has been shown to be as effective as conventional red light MAL-PDT in the treatment of AK, but with minimal to no therapy-related pain [30].
There is also an option for ambulatory PDT, where portable LED light source with low irradiance can be applied for over 100 min. Satisfactory results with clearing 11 of 17 lesions and minimal pain have been reported for treatment of BD and superficial BCC [31].
Topical photosensitizing drugs can also be applied for diagnostic purposes. Cutaneous fluorescence diagnosis (FD) is a promising dermatological procedure based on the combination of a local application of a photosensitizer such ALA or MAL and the use of a light source adapted to the absorption spectrum of these molecules. After topical application of ALA or MAL on the skin lesional and non-lesional areas, they are irradiated with blue light (408 nm). As PpIX shows red fluorescence when excited by blue light, PpIX accumulating cells can be visualized [32]. The detection of skin surface fluorescence can be made either by using simple handheld Wood’s lamp (long wave UVA) or by using CCD camera systems coupled to digital imaging and helps the clinician to differentiate lesions and perform either a guided biopsy or a controlled and complete resection of tumor, or even to identify persistent or recurrent disease. By using a commercial digital CCD camera system, together with digital imaging, the contrast of the acquired fluorescence images can be significantly enhanced and allows the determination of a threshold, which can be utilized either for a directed biopsy or for preoperative planning when Moh’s surgery is scheduled [33].
Furthermore, FD is probably a helpful tool to prove the efficacy of PDT. Limitations of this technique are the difficult interpretation and the low reproducibility of the obtained data. Most studies have mainly focused on BCC [34], AK and SCC [35] so far. Truchuelo et al. [36] showed that FS is a valid diagnostic tool in the diagnosis and follow up of BD with a comparable evaluation to clinical and histopathological results, a specificity of 85.7% and a 100% sensitivity (higher than clinical evaluation alone).
Although, FS cannot be used to differentiate the different stages of AK, it was shown that through differences in fluorescence ratio between AK and SCC, these entities can be differentiated [35, 37].
PDT with ALA or MAL conventionally begins with the topical application of the photosensitizers on the target area. In case of hyperkeratotic lesions, a keratolysis using an ointment, wet cloth or by slight non-bleeding curettage has to be performed prior to the application of photosensitizer as this may be the cause of a poor therapeutic response [38, 39].
ALA has been applied in various formulations such as creams or gels, sometimes with penetration enhancers. ALA preparations are usually applied to the target lesions with little overlap to the surrounding tissue for 4–6 h prior to illumination under occlusion and with a light protective dressing or clothing [40].
MAL is mainly applied in ointments which have a shorter incubation time of 3 h due to the preferential uptake and their higher selectivity [41, 42]. The entire area is then covered with an occlusive foil to allow a better penetration during the incubation which is then followed by illumination with blue light.
Pain is a major and serious adverse event during PDT and can lead to discomfort of the patient to incomplete treatments and need for repeat treatments [43]. The pain or a kind of burning sensation is mostly experienced during the time of illumination and a couple of hours later [9].
In a previous study it could be shown that MAL-PDT induces less pain in comparison to ALA-PDT which can be partially explained due to the differences in selectivity between the two substances [44].
Various pain-relieving approaches have been used in order to reduce pain during PDT. During extensive treatment fields administration of oral analgesia can be useful [45]. The application of local anaesthetics like lidocaine/prilocaine substances prior to illumination is generally not recommended. As previously shown also application of morphine 0.3% gel 15 min prior to illumination did not result in a significant reduction of pain as compared to a placebo gel [46]. Furthermore, due to their high pH local anaesthetics carry the risk of interaction during the incubation period of ALA/MAL and thus inactivate the photosensitizing drug. Wiegell et al. showed that application of cold water and regular pauses in illumination led to a considerable reduction of pain during PDT [47]. An alternative option with satisfactory results is a concurrent cold air analgesia which has been shown to improve the tolerability of ALA- and MAL-PDT [48]. Also analgesia by means of a nitrous oxide/oxygen mixture during PDT led to an overall reduction in pain of 55.2% and willingness of patients to continue the therapy [43].
Previous studies have also demonstrated that the type of light applied plays also a role in the development of pain. Therefore, PDT with the use of PDL coherent light, when compared to LED incoherent light led to less pain and increased willingness of patients to further perform the therapy [49].
Besides pain also burning and prickling sensations are common side effects of PDT. These sensations are usually mild to moderate in intensity and reversible [50]. In a previous study with ALA-PDT used to treat AK, it was found that about 96% of patients experienced stinging/burning sensations at 6 and 11 min during illumination. However, only 10% of them characterized pain intensity as severe [51].
Localized erythema and oedema in the treated area can also occur. Rarely a dry necrosis sharply restricted to the tumor areas can manifest over the next few days which is followed by complete re-epithelialization. Also pigmentary disorders presented as hypo- or hyper-pigmentation are also potential adverse effects of PDT treatment but are rare and of temporary duration. More often, pigmentary disorders have been noted prior to PDT-treatment and resolved at the last follow-up evaluation [51]. Allergic contact dermatitis, although extremely rare, can also occur by presence of sensitization against active ingredients of the applied sensitizers [52].
Due to the high selectivity and photosensitization preferentially to cells of epithelial origin and no fibroblasts or dermal fibers, usually no scarring or ulceration is observed clinically [9, 40]. Also irreversible alopecia could not be observed after PDT treatment series on the scalp despite the concomitant sensitization of pilosebaceous units [40, 53]. With the exception of a porphyria or previous allergic reactions to the active ingredients of the applied sensitizers in the medical history, there are no severe limitations to performance of ALA- or MAL-PDT. PDT treatment can be repeated and applied even in areas with prior exposure to ionizing irradiation [54]. During PDT treatment, both patient and clinic staff should be wearing protective goggles to avoid the risk of eye damage [38].
PDT is nowadays widely applied in the therapy of NMSC. The range of possible indications is expanding continuously, including non-malignant conditions and even premature skin aging due to chronical sun exposure. MAL is approved for use in Europe and United States in combination with red light for treating AK, superficial or nodular BCC and in-situ SCC or BD. A combination of an alcohol-containing ALA solution in a special applicator (Levulan Kerastick) and blue light is also approved in United States for the treatment of AK. For therapy of multiple lesions or by immunodeficient patients, PDT may be the treatment of first choice [23]. PDT is also indicated for patients with important comorbidities when surgery and radiotherapy are contraindicated. It may also be used for palliative care in combination with chemo- or radiotherapy for advanced tumors with skin metastases.
In the dermatological daily practice, PDT has some advantages compared to conventional treatments such as radiotherapy, chemotherapy and surgery. Some of them are the limited duration of the treatment, the efficiency and the good cosmetic outcome due to its high selectivity.
Actinic keratoses (AKs) are premalignant disorders of keratinocytes occurring on chronically sun-damaged skin. Although a spontaneous regression may occur in up to 20% of cases [55] there is a risk of transformation to SCC within one year between 0.025 and 16% [56]. Since AK manifests in chronically sun-damaged skin and there are often multiple lesions the exact risk of malignant transformation for individual lesions cannot be estimated [57]. Various treatment options such as cryotherapy, topical immunomodulation, laser and PDT are highly effective and recommended not only for individual lesions but also for field treatment [1, 58]. Several studies have been performed analyzing the efficacy of both ALA-PDT and MAL-PDT and comparing them with other procedures in treatment of AKs. Thin AK lesions or lesions of moderate thickness on the face and scalp respond well to topical PDT with clearance rates 89–92% 3 months after therapy [59]. A phase III clinical trial of ALA-PDT for the treatment of multiple AKs of the face and scalp found that 89% of patients had a remission of 75% or more of their AKs after 3 months of treatment [60]. Tschen et al. [51] reported remission rates of 78% 12 months after a single ALA-PDT treatment, with few adverse effects.
European guidelines recommend that for AK, MAL-PDT should be performed as a single treatment and repeated if required after 3 months, reflecting equivalent efficacy in a comparable study with a double therapy 1 week apart [59].
Also compared with other treatment options such as cryotherapy PDT achieves favorable outcomes [61, 62]. A novel self-adhesive patch ALA-PDT war superior to cryotherapy and placebo after 12 weeks in a multicenter phase III trial [61]. Also MAL-PDT achieved better therapeutic results compared to single cycle cryotherapy and placebo after 3 months in another large prospective randomized study [62]. When compared to double cycle cryotherapy for AKs on the extremities in a large randomized multicenter study MAL-PDT showed superior efficacy [63].
When compared with the topical application of 5-fluouracil (5-FU) twice daily ALA-PDT showed similar outcomes in mean lesion reduction [64]. Recently Tanghetti et al. reported that patients with AK who had been treated with 5-FU prior to ALA-PDT showed a significant decrease of clinical lesions after 1 and 3 months compared to these substances alone, which indicates that 5-FU has a synergistic role to ALA-PDT [65].
No significant difference was found in treatment responses of facial AKs to topical 5% imiquimod compared to ALA-PDT in a randomized, single-blind, split-face study [66]. Tanaka et al. [67] also compared the use of topical 5% imiquimod, with ALA-PDT but also with combination therapy in a randomized study. Although the combination group showed outstanding effectiveness, it was more frequently associated with adverse events, when compared to the PDT and imiquimod alone groups. There were no differences in either efficacy or adverse events between PDT and imiquimod monotherapy, however development of pigmentation was higher in the imiquimod therapy group.
Interestingly, imiquimod 5%, showed superiority in histological and clinical outcomes over MAL-PDT for face and scalp AKs, in a further randomized study [68]. The same study found that sequential MAL-PDT and imiquimod 5% are significantly more effective than each therapy alone, indicating that combination treatment may be beneficial [68].
Compared to CO2 laser ablation for the treatment of multiple scalp AKs in a randomized, half-side comparative study ALA-PDT showed superior efficacy [69]. By hyperkeratotic AKs, physical or chemical keratolytic pretreatment significantly improves the uptake of photosensitizer and light penetrance [70]. Topical application of 10% salicylic acid and 40% urea have similar efficacy to curettage, although chemical pre-treatment was associated with increased pain [70]. The recent introduction of ALA patch PDT reduces the need of keratolytic treatment prior to PDT [71].
Efficacy of PDT for AK on acral sites is reduced by approximately 10%, probably due to a higher proportion of thicker lesions. Compared to cryotherapy, MAL-PDT proved to be less effective for acral AK (lesion clearance 78% versus 88% after 6 months) [51].
Several novel methods of delivering PDT have been used for the treatment of AK, including the adhesive patch, daylight, ambulatory light sources and fractionated light protocols. PDT using the BF-200 ALA, has been recently licensed and proven to be superior to MAL with clearance of 90% versus 83% of thin or moderate thickness face/scalp AK (complete clearance rates of 78% versus 64%) 12 weeks after one or two PDT treatments [72].
PDT is identified as an effective therapeutic option both for lesion and field treatment for AK and by presence of multiple and/or confluent AK, at sites of poor healing, or where there has been a poor response to other topical therapies [73]. Also patient tolerance to MAL-PDT or topical imiquimod for multiple face/scalp AK and level of satisfaction were significantly higher by patients who underwent PDT treatment in a randomized comparison trial [74]. Figures 3 and 4 present clinical outcomes of ALA-PDT in AK lesions at the head and ear of two patients.
(A) Clinical manifestation of AKs on the head, (B) clinical outcome 4 weeks after one therapy-cycle consisting of double PDT-treatment in 1 week apart.
(A) Clinical manifestation of AKs on the helix of the left ear, (B) clinical outcome 3 years after therapy (there has been performed two therapy-cycles each consisting of double PDT-treatment in 1 week apart).
PDT is an established treatment for superficial and nodular types of BCC, but is not indicated for the more aggressive or infiltrating types [75]. Response rates of PDT in the existing literature vary between 70 and 90%, which may depend on the kind of tumors and the exact performance of PDT [76, 77]. MAL-PDT is approved in the EU for treatment of BCC, but remains off-label in the United States. Several studies have so far assessed the efficacy, cosmetic results and recurrence rates of BCC treated with PDT [78, 79, 80].
PDT has proven to generally be more effective for superficial BCC as compared to nodular BCC and also for lesions smaller than 2 cm [65, 66, 68]. Regarding the use of PDT for the treatment of larger and nodular BCC, MAL-PDT has proven to be a more effective treatment option with lower recurrence rates as compared to ALA-PDT [66, 68].
PDT appears to have good efficacy and cosmetic outcome but results in higher BCC recurrence rates in comparison to surgical excision [77, 79, 81, 82, 83]. Szeimies et al. [77] reported a similar efficacy at 3 months for MAL-PDT and surgical excision in the management of superficial BCC in a large randomized multicenter open study (92.2% clinical lesion response versus 99.2% in the surgical group). In a recent meta-analysis Zou et al. [83] found also that PDT is comparably effective to surgical excision for treatment of BCC, but with an increased risk of recurrence. Rhodes et al. [82] showed that the recurrence rate for primary nodular BCC after treatment with PDT was 14% versus 4% with surgical excision at the 5-year follow-up point. Data from other studies support that PDT leads to better cosmetic results compared to surgical excision [81, 82]. Also PDT serves as an effective alternative treatment option in difficult cases where an extensive surgical excision should have been performed carrying the risk of a worse cosmetic outcome [84].
When compared with cryotherapy for the treatment of superficial BCC, MAL-PDT led to comparable recurrence rates after 5 years, but better cosmetic results [85]. In a recent three-year follow up randomized controlled trial Roozeboom et al. [86] compared the efficacy of MAL-PDT, topical imiquimod and 5-FU on the treatment of superficial BCC. Topical imiquimod has shown superiority to MAL-PDT (tumor-free survival 58.0% for MAL-PDT versus 79.7% for imiquimod) but comparable results with 5-FU (68.2%).
For nodular BCC, variable response rates have been reported in several studies. Rhodes et al. [82] observed comparable response rates for primary nodular BCC treated with MAL-PDT or surgical excision at 3 months (91 and 98%, respectively), again with greater recurrence rates but better cosmetic outcomes in the PDT group. The same group showed in a later randomized study persistent complete lesion response rates at 5 years which were 76% for MAL-PDT und 96% for surgical excision of nodular BCC. PDT led consistently to better cosmetic outcomes [87]. On the contrary, Mosterd et al. [88] showed in a further randomized controlled study of 173 primary nodular BCCs that surgical excision was significantly more effective compared to a single treatment of fractionated ALA-PDT, with a failure rate of 2.3% compared to 30.3% for PDT at 3 year follow up. Performance of two ALA-PDT treatments for both nodular and superficial BCC has given comparable clinical response rates to surgery (95.83% complete response versus 95.65%). Recurrence rates were also similar (4.16% versus 4.34%) [81]. In the longest follow-up study to date lasting 10 years, Christensen et al. [89] found that the overall complete response rate for all subtypes of BCC treated with ALA-PDT was 75%, with a 60% complete response after one treatment and 87% response after two treatments.
More aggressive types of BCC, which often occur on the face, show a greater frequency of recurrence, possibly due to genetic mutations resulting to resistance to apoptosis [75]. Although long-term recurrence may limit the use of PDT for nodular BCC, PDT seems to be suitable for cases where surgical excision is not appropriate. On the other side, randomized studies with only short-term follow-up had previously reported high efficacy for facial nodular BCCs treated with MAL-PDT [90].
Since thickness of the tumor can affect the penetration capacity of the photosensitizer, various methods have been already used prior to PDT as pre-treatment in order to enhance its efficacy. Therefore, dimethylsulphoxide (DMSO), which alters the intercellular lipid structure of the stratum corneum, has been used as a pretreatment penetration enhancer [91]. Curettage and DMSO pretreatment prior to one or two sessions ALA-PDT brought favorable 10-year response rates of 75% for primary small BCC [89]. Also intralesional ALA and light source application showed promising results in a small prospective study of 20 patients with nodular BCC, with no clinical recurrence observed after 19.5 months [92].
Combination of PDT with Mohs micrographic surgery has also been performed with beneficial outcomes by reducing the tumor size and thus improving the cosmetic outcomes [93, 94].
PDT can be a useful option for patients with naevoid BCC syndrome (Gorlin syndrome) depending on the localization and thickness of the lesions [95]. In these patients can MAL-PDT significantly improve patient satisfaction and reduce the need for many surgical procedures [96].
Although topical PDT does not serve as first-line therapy for BCC, it is recommended for primary superficial and thin low-risk nodular BCC but is a relatively poor choice for high-risk lesions including nodular BCC [97]. PDT is best considered for nodular lesions where surgical excision is relatively contraindicated, or where patient preference, reflecting past therapy history, comorbidities or cosmetic considerations, although the higher risk of recurrence has to be taken into consideration. It is advised that patients receiving topical PDT for nodular BCC are reviewed for evidence of recurrence for at least 1 year. Further long-term studies are needed to better assess the effectiveness of PDT on BCC. Figure 5 demonstrates the treatment and clinical outcome after ALA-PDT on a superficial BCC.
(A) Clinical manifestation of a superficial BCC, (B) selective detection of fluorescence after application of ALA on the lesion during PDT, (C) clinical outcome 3 years after therapy (there has been performed one therapy-cycle consisting of double PDT-treatment in 1 week apart).
PDT has been also used for treatment of Bowen’s disease, or squamous cell carcinoma in situ and is recommended for both extensive involvement and poor healing sites [98]. The approved MAL-PDT dosing regimen for Europe consists of two treatments 7 days apart, repeated at 3 months, if needed [99].
The clearance rates reported for BD lesions are high between 86 and 93% 3 months after one or two treatments of MAL-PDT using red light, with sustained clearance at 24 months of 68–71%, which is comparable with the conventional therapy, but with better cosmetic outcomes [100]. MAL-PDT was effective in treating lesions over 3 cm, with clearance rates of 96% in 3 months after one cycle of two treatments, with only three recurrences in a follow-up of 1 year [101]. Comparable outcomes have been reported form an observational study of 51 BD lesions which had been treated with two MAL-PDT treatments one week apart leading to clearance rates of 76.09% at 16.61 months with excellent cosmetic outcome and only mild cutaneous adverse effects [102].
Compared to cryotherapy and topical 5-FU, MAL-PDT showed similar response rates for BD at the 12 month follow-up point but superior cosmetic results [103]. Also ALA-PDT has been found to be significantly more effective for BD than topical 5-FU at 12 months (82% versus 48% complete clearance) at 12 months [104]. ALA-PDT compared to MAL-PDT, respectively, showed an 89% versus 78% response rate, at approximately 6 months after treatment [101].
Therapy guidelines recommend PDT as the treatment of choice for both large and small plaques of BD on poor-healing sites, representing the majority of lesions and a good choice for large lesions in good-healing sites [105]. However, larger studies with longer follow-up are needed to better assess response rates.
For invasive SCC there is a reduced efficacy of PDT where 24-month clearance rates of 57 and 26% have been reported. The degree of cellular atypia is a negative prognostic factor, suggesting that poorly differentiated keratinocytes are less sensitive to PDT because of reduced sensitivity to phototoxicity or decreased production of PpIX.
In some cases of invasive SCC, PDT-therapy was followed by resistance resulting in more aggressive disease. Gilaberte et al. [106] postulated that chromosomal instability is the reasonable factor through the induction of overexpression of CCND1 and aberration of the MAPK/ERK signal pathway, as previously shown in immunodeficient mice.
In view of its metastatic potential and reduced efficacy rates, PDT currently cannot be recommended for invasive SCC [100].
PDT can also be a useful treatment option by organ transplant recipients who are at an increased risk of NMSC and especially SCC due to long-term immunosuppressive therapy. Treatment with cyclic ALA-PDT at 4–8 week intervals over a 2-year period on 12 organ transplant recipients led to a significant reduction of SCC (98% mean reduction) [107]. Wennberg et al. [108] also found that repeat MAL-PDT treatments reduced the occurrence of new AKs in this special population.
Since the incidence of NMSC is increasing over the years, available therapies should aim to deliver good cosmetic outcomes and optimize patient comfort while still achieving acceptable response rates. PDT offers an attractive alternate to surgical treatment of NMSC, as well as an alternate to non-surgical treatments such as cryotherapy, imiquimod and 5-fluorouracil. Conventional PDT is in comparison to daylight PDT a well-tolerated treatment method, with pain during and shortly after treatment being the main adverse effect.
MAL appears be associated with lower pain levels than ALA, which may be due to its greater selectivity for neoplastic lesions. New strategies, such as cooling and inhalation of a nitrous oxygen/oxygen mixture, are promising treatments to minimize pain. MAL also requires shorter incubation times compared to ALA, according to the FDA-approved treatment regimen. PDT utilizing ALA and MAL is a proven and even first line treatment for AK and superficial BCC. PDT has also demonstrated efficacy in treatment of nodular BCC and SCC in situ, although recurrence rates higher than those of standard surgical treatments preclude first-line use of PDT for these indications. Studies with MAL-PDT for superficial BCC offer acceptable response rates to consider it a reasonable therapeutic option for patients who are not eligible for surgery or do not desire surgery. PDT should be utilized with caution for nodular BCC and Bowen’s disease given the risk of recurrence.
New strategies for improving the efficacy and tolerability of PDT are under continuous development. Although several classes of novel photosensitizers have been proposed, they seem to be of no advantage regarding the overall efficacy of PDT [109]. Novel delivery systems such as nanoparticles, micelles or liposomes which are promising technologies leading to a better uptake and targeting of photosensitizers may be available in the future.
New indications for PDT including cutaneous infections, inflammatory dermatoses, cutaneous T-cell lymphoma or treatment of skin photo aging are also under investigation.
“Greenspace” the word itself is so vast for the academicians that it has been used by researchers differently in different contexts. With the revolutions in the research of sustainability, the term “green” not only symbolizes trees and vegetation but is also used as an adjective for environment-friendly built environments and even technologies. In urban planning, the term “greenspace” is referred to as the vegetation cover of the spatial area. Greenspace is an urban space that fulfills various esthetics, air purification, conservation of ecology, etc. Urban green spaces (UGSs) in cities exist as natural or semi-natural, managed parks and gardens, supplemented by scattered vegetation pockets associated with roads and random green spaces [1].
Some traditional and cultural parameters, including health, ecological, social, and recreational, remain a major deterministic factor for the optimum usability of these spaces. These UGS can be accessible or inaccessible within city areas. Accessibility of green spaces is an important aspect to assess its impact. There are many UGS within the city area which are inaccessible to the public, and thus citizens are not able to avail themselves of its best benefits. In such cases, green space may not perform its function. Therefore, it is necessary to understand the context of green spaces in urban planning. To further elaborate the green space, ‘public open spaces’ is another term that can further help understand the concept, functionality, and psychological impact of the population affected by green spaces. UGS include natural elements like green belts, soil, water, parks, etc. have a positive effect on human wellbeing, as shown in Figure 1.
UGS in Chandigarh city, India (Chandigarh is the first the planned city of India by architect-planner Le Corbusier and is famous for its green spaces integration in the master plan). (Source: author).
The sustenance of human life on Earth is entirely due to a natural environment and large biodiversity functions. Fresh air, water, fruits, woodlands and minerals are all provisioned by various ecosystem services. Green spaces in cities serve as a natural gathering place for the community, fostering social interaction and integration. They also promote individuality and belongingness to urban areas. The effectiveness of UGS to attenuate air pollution is enhanced by vegetation density. Urban greenery provides a safe and healthy atmosphere for walking, jogging, and running and a conducive environment for social contact and physical and leisure activities. Consuming the maximum benefits of city greens requires them to remain unaltered by the urban infrastructure such as the buildings, highways, and other infrastructural components. The current times require greens to be planned as ecological functional spaces coexisting to support the human functions of recreation, esthetics, leisure activities and conserving environmental values.
Vacant built-up space remains as elapsed wasteland or gaps between buildings and other constructions. These spaces have a high potential for reconstruction and repurposing by integrating them into the public, and for creating stunning spaces by distinguishing their specific character. For example, the exact characteristic of a former railway track is that it connects two regions and can be renovated into a green corridor. Depending on their location, abandoned areas can be converted into different facilities. Every city has such vacant spaces that are waiting to be adapted to the current urban fabric so that they can be part of the total cityscape.
An environmental justice issue that affects so many communities is the lack of green space. Most cities have green areas throughout them for the health of the citizens. In areas that are predominantly lower income or a minority group tend to have less green space. Green spaces are very important to maintain good air quality and promote exercise [2]. There are many cases of this environmental justice problem that were acknowledged and even fixed. A few examples are Tartu, Estonia, Faro, Portugal, and Phoenix, Arizona. Green space is something everyone should have equal access to, but due to the environmental justice problem certain groups are deprived of easily accessible green space.
Living near a green space might even help you live longer. A scientific review published in The Lancet Planetary Health found urbanites living near a park or a garden had a lower risk of premature passing. In their work, the researchers used a vegetation index to measure the density of greenery in locales. Using their scale, infertile areas composed of rocks or sand would score closer to a zero, while an area like a lush tropical rainforest would score closer to one.
The chapter holistically covers and generalizes concepts and concerns associated with UGS across urban planning domain. The chapter is written based on the review and analysis of secondary data available in the form of published literature from reputed data sources, government reports and based personal observation of the author may during the course of study.
The green space can be differentiated from open space as it constitutes only a two-dimensional land area that has not been modified to buildings, highways, and other infrastructural components. Greens should be mainly classified into an ecological function space (flora and fauna, physical infrastructure (drainage, stormwater management, and water quality conservation), and human function (provision for recreational, aesthetical, emotional, and leisure activities, preservation of environmental values, and solar access). Green space may consist of a vast range of pre-hold and leasehold land tenure with different use and access rights. Green space may also find its share in further land-use planning.
In the early 1700s, garden squares and parks were firstly introduced in urban areas. In the late eighteenth and early nineteenth century, the parkway movement, headed by Frederick Law Olmsted, led to the belief that green space was an important cultural and social element of the urban form. The idea of integrating green space into the urban development process came out with the regeneration of the environmental movement in the 1960s [3]. Although public access is defined for various green spaces, green space does not imply public accessibility automatically. Here the green space categories the open spaces which support human socio-cultural and health requirements, biodiversity preservation as well as discussion related to historical green space perspective [4, 5].
There are different types of green spaces like food production areas, national parks, grasslands, green belts, and playfield (like a golf course) that are predominately utilized for corps and live stocks, habitation to animals and medicinal herbs, cattle grazing, the barrier between the pavement and human settlement, and sports activity respectively. Green space categories intermingled with the next one, parks and gardens, where the needs of individuality for recreation and enjoyment are fulfilled [6, 7]. Table 1 shows the Indian UGS typology according to the designated documents with different contexts, categories, classification, and other hierarchies.
Many cities in India have a categorization of spaces that are derived from literature (Table 2). And then, there is a hierarchy of classification of categorized spaces. The planned cities have systematic cataloging of green spaces like the recreational spaces, green areas and tourist areas. Each town has its USP (unique selling point), and it offers the spaces it has according to its function. Table 3 showcases the different cities of India and how they have their green spaces categorized, their further classification and the hierarchy.
Documents | Context | Category | Classification | Hierarchy |
---|---|---|---|---|
UDPFI (1996) | Open spaces | Recreational facilities | Parks and open spaces Sports centers and playgrounds Botanical and zoological parks Water bodies/other natural features Places of tourist interest | Housing cluster Sector Community District Sub-city center |
URDPFI (2014) | Open spaces | Recreational space Organized green Other common spaces (such as vacant lands/open spaces including flood plains, forest cover etc. In plain areas) | Recreational | Recreational P-1 Playgrounds/stadium/sports complex P-2 parks and gardens—public open spaces P-3 multi-open space (Maidan) Organized green Housing cluster Neighborhood Community District/zone Sub-city center |
Urban Green Guideline (2014) | Green spaces | Urban greens | Reserved forest Protected forest District park Neighborhood park Tot-lots Playgrounds Green belts (buffer) Green strip | Tot lot Playground Neighborhood park Community park |
Indian UGS typology.
Typology | International typology | Indian typology |
---|---|---|
Amenity green space | Recreational green space Parks and gardens Outdoor sports areas Green street space Private green space Green roofs Courtyard Greenery at housing estates Greenery at commercial buildings | Reserved forests Protected forests National parks Sanctuary |
Functional green space | Green trail Car parking space Pedestrian area Stormwater retention area Old landfills/dumps Productive green space Remnant farmland City farms Cemeteries/churchyards | City parks District parks Neighborhood parks Tot lots |
Linear green space and open spaces | River and canal banks Transport corridors—road/rails | Green belts (buffers) Green strips Transport corridors |
Natural and semi-natural spaces | Wetlands Woodlands Vacant land Post-industrial land | Playgrounds |
Green corridors | Tree belts Canal and riverbanks Disused railways | |
Allotments, community gardens, and urban farms | Allotments Community gardens City farms | |
Outdoor sports facilities | School playing fields Community playing fields | |
Provision for children and young people | Facilities for young people Community parks Children’s play area | |
Privately usable areas | Facade greening Roof garden Front garden Courtyard Balcony | |
Leisure areas | Campsite Multifunctional leisure facility Sports ground | |
Eco-sensitive areas | Waterlogged Marshy Swampy |
Categorization of green spaces according to the typology.
City name | Categorization of spaces | Classification of categorized spaces | Hierarchy of classification of categorized spaces |
---|---|---|---|
Jaipur | Recreational space/tourism zone | G1 eco sensitive areas G2 green zones G3 parks | Parks Gardens Stadium Sports ground |
Jodhpur | Recreational space | Parks and open spaces Stadium and play grounds Fair and tourism Public entertainment | No further classification |
Sriganganagar | Recreational space | Parks, open spaces and playground stadium | No further classification |
Chandigarh | Recreational space/green areas | Sports facilities Cremation ground Cultural facilities | Organized open space Forest Agriculture |
Naya Raipur | Recreational space | Open spaces | Film city Parks and play areas Stadium and sports complex Nature resort/theme park Reserved forest Botanical park, jungle safari |
Lucknow | Recreational space/green areas | Parks and open spaces | No classification |
Pune | Recreational space | Community hall Museum/theaters Parks and open spaces | No classification |
Varanasi | Recreational space | Gardens, open spaces and urban forest | No classification |
Panaji | Recreational space | City level parks and playgrounds | Housing area park Neighborhood park Community park District park |
Pudducherry | Recreational space/tourism zone | Open space | Parks Gardens Stadium |
Categorization of green spaces according to the typology.
Figure 2 shows an overall view of UGS and countries’ happiness worldwide. This map highlights regional differences in the green space distribution due to climate; countries near the Equator in tropical climates have relatively high UGSs, while countries in the 20–30 latitude range have exceptionally low UGSs due to the dry climate. The UGS increases with latitude in higher-latitude regions. On the other hand, Northern and Western European and North American countries display relatively high happiness scores. Western Asian countries also show relatively high happiness with a low UGS, indicating that the relationship between happiness and green space is not trivial.
UGS and happiness index of countries worldwide (a) The map of urban green space and happiness in 60 developed countries. The size and color of circles represent the level of happiness and urban green space in a country, respectively. The markers are placed on the most populated cities of each country. (b) Histogram of happiness (c) Histogram of UGS (d) Histogram of log-GDP.
The distribution of UGS and happiness over the world. (a) The map of UGS and happiness in 60 developed countries. The size and color of circles represent the level of happiness and UGS in a country, respectively. The markers are placed on the most populated cities of each country. (b)–(d) The histograms of (b) happiness, (c) UGS and (d) logarithmic GDP per capita (log-GDP). We use the logarithm of the total NDVI per capita as an indicator of UGS and the logarithm of GDP per capita as a measure of wealth.
The usage of Greenspace for recreation and leisure purposes led to the identification of its economic, cultural, environmental, and social values, which further increased the attention on its management and planning. In this chapter, the focus is on the relationship of Greenspace to human interaction on various levels of livability, recreational purposes and improved quality of life. The other perspective describes urban vegetation, such as parks, yards, and gardens related to a green stuff kind of open space. This perspective may be defined as a subsidiary of a comprehensive notion of Greenspace, i.e., limited to the built-up environment subsection of open space.
UGS are critical for making our cities sustainable and energy-efficient [8]. However, for UGS to contribute to the optimum, they have to be planned, designed, developed and managed/maintained appropriately so that they are accessible both in terms of area and population coverage. It is a fact that urbanization in India will continue unabated. The Urban Greenspaces generate diverse ecosystems of substantial significance for human wellbeing and human activities, shaping their dynamics. Many green spaces in cities disconnected from the wider environment tend to lose biodiversity due to continuous construction activities. Hence, protecting green spaces in isolation will often fail to sustain the capacity of urban ecosystems to generate value and have to be well integrated into the overall city landscape.
Figure 3 shows the distribution, parts and sub-parts of the UGS.
Synonymous nature of UGS.
Furthermore, the socio-cultural, functional, health-related aspects are labeled for a specific place, i.e., “Greenspace”, as a park or recreational area [9]. Sprawling population, commerce, industries, transportation accelerated the gross domestic production, varied product availability to the consumers, and more excellent connectivity. With the high-rise demand of time, the researchers explored the correlation between these sectors and related aspects of “Greenspace”.
Typology | Definition |
---|---|
Natural land | Unoccupied/unused lands, left unturned by the authorities or the locals, come under this category. Grasslands are also a big part of the natural land group. |
Green belts | Green belts of buffers include green girdle, park belt, rural belt, agricultural belt, country belt etc., which generally refers to a stretch between towns or regions separating one from the other. These areas are dominantly farmlands as they support agriculture and related functions. Green belts are established to keep in check the growth of the built-up regions, preserve neighboring towns from merging and also maintain a unique character of a town. |
National parks | National park is an area that is protected and conserved due to the presence of remarkable natural flora, fauna, geological formations and natural scenic spots. |
Reserved forests | Area duly notified under the Indian Forest Act, 1927 or the State Forest Acts having complete protection. All activities inside are prohibited unless expressly permitted. |
Protected forests | They are found in urban and peri-urban areas secured by fencing or constructing a compound wall, or both. Here no construction activity is allowed. |
District parks | It is a designated term per the hierarchy of green spaces in an urban city. It is a prominent use of a vast green area and developed as a crucial green space in a city. As per UDPFI guidelines, one district park serves 500,000 of the population in plain areas. |
Typology | Definition |
---|---|
Campsite leisure | Land that is dedicated to camping acquires a significant part of the green space category, especially in the trekking zones of any country |
Wetlands/marshy land | A wetland is a part of the ecosystem flooded by water, either permanently or seasonally. Wetlands are considered amongst the most biologically diverse of all ecosystems, serving as home to a wide range of plant and animal species. |
Functional green space | Spaces like cemeteries, pedestrian area, landfills, farms, etc., are functional green spaces. These areas acquire land which is usable for the users. |
Playing fields | As part of any institution/university/school, fields serve as a decent open area for any city. It enables the users to use it for any leisure/formal purposes. |
Typology | Definition |
---|---|
Linear green space | Areas like pedestrians, river canals, street trees are included in Linear Green Space. It adds to the esthetic and usability value of any city. |
Green stripe | A green strip is developed on vacant land, for instance, land under high tension power supply lines. It is also developed along the arterial roads, separating residential areas from other land uses. |
Green roof/facade | Green roofs are the most popularly deployed form of roofs; they are generally lightweight and low cost. They are purposely fitted or cultivated with vegetation. They are also be known as living roofs, eco-roofs or vegetated roofs. They can reduce both heating and cooling loads in buildings. This has positive implications in terms of their energy consumption. The green roofs and facades increase the esthetic value of the scape. |
Neighborhoods parks | It is developed at the neighborhoods level for a population of 10,000. Neighborhoods Parks are conveniently located within the developed residential areas, preferably within walking distance. It is planned on a site of 2000−4000 m2 |
Indian city | Typology |
---|---|
Chandigarh: The capital city has a forest and tree cover of 35.5% in its 114-km2 area. Chandigarh has become the greenest city in the country. The tree cover saved the city from becoming an all-concrete jungle, a fate that has overcome many Indian towns. | The green belts of Chandigarh also facilitate a healthy population of diverse birds. The parks along the spine of Chandigarh include Rajendra Park, Bougainvillea Garden, Leisure Valley Garden, Zakir Rose Garden, Shanti Kunj, Bamboo Valley Garden, Bulbous Hibiscus Garden, Fragrance Garden and Dahlia Garden. |
See Figure 4.
Indian city | Typology |
---|---|
Delhi: The capital of India is one of the greenest capitals in the world due to the consistent emphasis on greening and strict monitoring of tree cutting. | Recently, the parks and garden society has been set up to coordinate the greening activities in Delhi. The city has some well-maintained parks and gardens like Lodhi Gardens, Mughal Gardens, Deer Park, Budha Jayanti Smarak Park, Indraprastha Millennium Park and The Garden of Five Senses besides the Ridge. |
Plan of Chandigarh.
See Figure 5.
City abroad | Typology |
---|---|
New York – Central Park: Central Park is an urban park in New York City located between Manhattan’s Upper West and Upper East Sides. It is the fifth-largest park in the city, covering 843 acres (341 ha). It is the most visited urban Park in the United States, with an estimated 42 million visitors annually as of 2016, and is the most filmed location in the world. | The Park has natural-looking plantings and landforms, having been almost entirely landscaped when built in the 1850s and 1860s. It has eight lakes and ponds created artificially by damming natural seeps and flows. Several wooded sections, lawns, meadows, and minor grassy areas. There are 21 children’s playgrounds and 6.1 miles (9.8 km) of drives. |
Plan of Delhi.
See Figure 6.
City abroad | Typology |
---|---|
London – Hyde Park: Hyde Park is famous for being the largest Park in Central Park and the royal parks of London and its speaker’s corners. | Hyde Park is a Grade I-listed major park in Central London. It is the largest of four Royal Parks that form a chain from the entrance of Kensington Palace through Kensington Gardens and Hyde Park, via Hyde Park Corner and Green Park, past the main entrance to Buckingham Palace. The Park is divided by the Serpentine and the Long Water lakes. |
Plan of New York Central Park.
See Figure 7.
Plan of London Hyde Park.
Different direct accessibility Greenspace typologies provide ecological benefits such as ambient temperature, air and noise pollution reduction, water harvesting, and a barrier between pavement and locality. Green Space provides indirect health benefits instead of direct benefits. These green spaces offer various herbs, vegetables, cereals, fruits, etc., supporting human health. Flourished greenspaces promote tourism, health wellness product vending and fetch high real sale values for the properties near parks and greenways. Apart from these direct benefits, many researchers have established many indirect benefits of Greenspace, which will be discussed later in this chapter.
Recreation opportunities, Areas that are culturally and historically valuable. It has an impact on physical and mental health. Green spaces provide a refreshing contrast to the harsh shape, color, and texture of buildings and stimulate the senses with their simple color, sound and smell. Particular types of green space may offer a bigger diversity of land uses and opportunities for a wide range of activities, help to foster active lifestyles, and can be of real benefit to health.
Green Spaces add to the Landscape features of any cityscape; screened views are formed from different angles of the city. Growing trees and experiencing nature is a path to a positive passive lifestyle.
Air pollution reduction, Sound Control, Glare and Reflection reduction. Impacts on urban climate through temperature and humidity control. Urban forests act as temperature buffers providing shade in the summer and windbreaks in the winter in addition to reducing noise pollution and CO2 levels and providing a habitat for wildlife [10]. Urban greening improves air, water, and land resources by absorbing air pollutants, increasing water catchment in floodplain surfaces, and stabilizing soils.
Biotopes for flora and fauna in any urban environment is benefitted and, in turn, help the environment. Trees absorb pollutants; moderate the impact of humans, absorbing pollutants and releasing oxygen. They contribute to maintaining a healthy urban environment by providing clean air, water and soil. Green vegetation has been shown to lower wall surface temperatures by 17°C, which led to a reduced air conditioning load by an average of 50%. They improve the urban microclimate and maintain the balance of the city’s natural urban environment [11]. They preserve the local natural and cultural heritage by providing habitats for various wildlife and conserving a diversity of urban resources.
Tourism is increased due to the aesthetical change in any scape. The property value is increased—the value of market-prices benefits [12]. Property owners value urban greenery by the premium they pay to live in the neighborhood of UGS and public parks. Plots and flats adjoining Park add to the value. In densely populated areas, this effect is even more noticeable. For example, the view of green spaces and proximity to water bodies increases the real estate prices. The impact of neighborhood parks on the transaction price of multi-storied residential units in cities illustrates that neighborhood parks could increase the cost.
Humans appear to adapt to almost anything in their environment, including air pollution, noise and environmental dullness. Man’s apparent ability to adapt may be his most significant liability. On the one hand, it allows him to adjust to slowly developing adverse conditions; on the other, it could easily threaten his survival. Adaptability permits human adjustment to damaging environmental circumstances we aren’t aware of. When environmental conditions deteriorate to a point where they are readily apparent, it may be too late to reverse the cycle. If an individual has a feeling of wellbeing in the built environment that surrounds him, it is reflected in his activities. The type of space that covers us can either stimulate or be in habitus. Some have tried to isolate how spaces (man-made and open space) play a behavior role in our way of life and specific ways of thinking. While these studies can be rationalized from many perspectives, a case can be made that the type and amount of spaces in our urban areas do, to some degree, shape our social behavior. As urban life becomes more stressful, the more significant the influence of open space [13]. Stress is most pronounced in low-income neighborhoods.
Higher-income neighborhoods outside our major cities tend to be less densely populated, which may reduce the resident’s perceived need for public open space. Often, the lower a neighborhood’s economic scale is, the less likely it becomes for that neighborhood to have the available space and recreational activities required for good physical and mental development.
Placing an economic value on urban open space related to public benefits is a difficult task. Land value in a free enterprise system depends on supply and demand. The value of the real estate is directly proportional to the market demand, potential use, and rights of ownership within its geographic locality. Publicly owned open space used for recreation does not fit into the regular private land market. The parcel’s value as open space cannot be measured in dollars in the same way as land or improvements for a commercial venture.
One method of estimating the economic value of public open space is to monitor the success of a program and determine the revenue that is directly or indirectly generated by it [14]. At the same time, public parks are primarily supported by tax dollars appropriated through the general fund.
More indirectly, open space generates revenues by enhancing the value of adjacent private properties. For example, a 1977 study in Chicago concluded that property prices were $1000 higher for parcels within one block of an urban park as compared to a similar area. Hammer [15] estimated that for each acre of a public park adjacent to a stream, sur-rounding private property values would increase an average of $2600.
Ecological considerations directly related to land and resource preservation often are neglected. These include the function of open space for water-shed management, environmental quality, and esthetic appreciation.
Greenbelts adjacent to natural water bodies can reduce sedimentation, increase preservation, reduce the need for excessive flood control projects and lessen flood damage [16]. Areas of open space can:
Ensure groundwater recharge.
Improve water quality by reducing soil erosion and sedimentation.
Increase recreational benefits, such as nature study, fishing and boating.
Sustain wetlands, which provide wildlife habitats.
Absorb peak water discharge and naturally filter some of the suspended pollutants.
Keep lake and stream levels more constant over the entire year.
Enhance the community appearance.
The benefits of green spaces for our cities are well documented, but they are seldom given desired attention with other computing land uses such as the residential, commercial and industrial use within the urban planning process. Negligence by planning authorities and decision-makers results in not meeting the quantitative and qualitative standards of green spaces and results in their unequal distribution on the spatial scale. Inaccessible green spaces within urban centers also raise concerns regarding city dwellers’ utilization. Primarily new developments in urban centers diminish the future opportunities for recreational provision, and most often, the existing green spaces are not very well managed. Various UGS planning and management issues are thus identified in the subsequent subsections.
The quality of green space is a critical determinant to assess its value to the urban population. In generic terms, the quality of green space is understood in terms of its esthetic outlook and the level of facilities served by it. But in the spatial planning domain, the density of vegetation and the spread of tree crowns can be realized as they essentially lead to the several ecological and social benefits associated with green space. Improved physical and mental health, reduced stress levels, and increased happiness and satisfaction amongst citizens indicate the existence of superior quality greens in the city. Scenarios of degenerating UGS quality are well reported across many cities [17]. The city of Bengaluru in India has seen a decrease of 78% in green cover over the course of four decades, along with its deteriorating quality. These scenarios can be related to rising accounts of air pollution, obesity, shrinking health, and social and psychological collapse amongst the citizens. Overall degenerating quality of the greens and cities can be associated with multiple factors such as lack of maintenance, not choosing native trees, urban sprawl on green belts and ecological areas, deterioration of green riverfronts and loss of biodiversity in forests.
Policy frameworks in an urban planning setup are intended to guide associated decision-makers in the field towards achieving suitable outcomes related to various city infrastructures. Provision, maintenance and broadening of appropriate green covers in cities require policy measures supporting the existence and promotion of several ecosystem services delivered by UGS. Recommendations made by World Health Organization (WHO) suggests the availability of a minimum of 9 m2 of green space per person, ceases the intent at large of appropriate green space provision policy as it follows the ‘one size fits all approach and neglects varying physical and social circumstances across world cities [18]. Furthermore, catering to large densities in urban centres, many cities fail to meet the standard. For example, (see Table 4) amongst many Indian cities, only a few cities like Chandigarh, Delhi, and Bangalore meet the WHO standard, and numerous like Mumbai, Ahmedabad, Surat, Chennai, and Hyderabad miss it on a large scale.
City | City area (km2) | City population in million (census 2011) | Area of UGS (km2) | Per capita UGS (m2 per person) |
---|---|---|---|---|
Chandigarh | 114 | 1.05 | 50 | 47.37 |
Delhi | 1484 | 16.34 | 324.44 | 19.84 |
Bangalore | 709 | 8.43 | 150 | 17.80 |
Mumbai | 735 | 18.45 | 122 | 6.61 |
Ahmedabad | 464 | 5.57 | 21.8 | 3.91 |
Surat | 326.5 | 4.46 | 11.84 | 3.32 |
Chennai | 176 | 8.69 | 11 | 1.26 |
Hyderabad | 172 | 7.75 | 8.72 | 0.88 |
Per capita UGS in Indian cities.
Source: author.
The Ministry of Urban Development sets out urban and regional development plan formulation and implementation (URDPFI) guidelines for, Government of India and suggests appropriate urban development standards. It identifies UGS as part of organized greens within the city’s social infrastructure and categorizes them based upon their spatial hierarchy as housing area, neighborhood, community, district and sub-city parks (see Table 5). The population to be served per unit and associated area requirements are mentioned within these categories. Such standards meet the quantitative aspects of UGS, but attention to their physical distribution and accessibility in regards to providing the serving radius is missed out.
S. no. | Category | Population served per unit | Area requirement (ha) |
---|---|---|---|
1 | Housing area park | 5000 | 0.50 |
2 | Neighborhood park | 15,000 | 1.00 |
3 | Community park | 1,00,000 | 5.00 |
4 | District park | 5,00,000 | 25.00 |
5 | Sub city park | 10,00,000 | 100.00 |
Categories of UGS in Indian cities as per URDPFI guidelines.
Source: URDPFI, volume 1.
Indian cities broadly vary in topography, and thus while setting out UGS standards and policy measures, it is crucial to incorporate their diverse local climate context and cultural practices, which these standards miss out on largely.
Developing the proper functionality of an UGS is vital to make it enduring. In the context of UGS associating them with the recreational programming during the planning process, it drives them to become more functionally sound and exciting and vibrant for citizens use. But a large number of green spaces in urban centers lack on this front as greens existing across the riverfront, green belts and even large cities scale greens are usually found with the least footfall and thus are encroached by slums and squatters [19]. Even in low hierarchy greens such as local or neighborhood parks, the absence of supporting recreational amenities such as sitting area, walking pathways, sports facilities, biking trails, open gyms, etc. are either not found or are not so well maintained. One of the studies in the Alexandria city of Egypt brings forth the lack of recreational programming of UGS and how it negatively affects the usability of city greens by the urban citizens (see Figure 8).
Inappropriate recreational programming in Al Shalalat park Alexandria, Egypt. (Source: 2003; De Sousa; thinking brownfields into green space in the city of Toronto).
Improving the UGS scenarios in our cities requires strategic measures with the coordinated efforts of all decision-makers and the stakeholder’s participation. These measures would intend to improve the qualitative and quantitative structure of urban greens in our cities, ensuring equitable distribution and making the greens accessible for citizens. Improving the planning process, strengthening the spatial data, enhancing quality greens, applying ecological principles, using altered greening practices and promoting public participation are discussed in the subsections below as the strategies for UGS improvements.
UGS assists sustainable development by being environmentally, socially and economically viable. The accustomed green planning process involves using standards approach wherein a set of standards are used while deciding greens provision. The standards approach ensures enough green spaces exist in cities, but it often compromises other vital aspects. UGS should be of satisfactory quality, adequate quantity, well-distributed and variably accessible [19, 20]. The process of determining standards should be appropriate for the greens’ of the greens and should be custom made. They are using local intensive methods such as neighborhood index which are more suitable for the green planning process. The planning process needs to be flexible enough to take in the political change occurring in the cities and should integrate a multi-disciplinary approach involving natural, social, economic, planning, and legal components.
UGS are a system of ever-evolving complexity, and to plan them effectively, spatial information is required that is fine, vigorous, and constantly updated. Geographic Information System (GIS) is one such tool that processes the geospatial data from satellite imagery, aerial photography and remote sensors helping to understand the current green spaces needs. It puts together vast amounts of spatial information and thus assists in analyzing the areas of priorities for UGS and determining the feasibility of developing new green sites in our cities [21]. In GIS, one can run numbers on queries, monitor fluctuations, predict environmental effects and thus help urban planners seek amplified visibility into the available data. Improved public participation is also achieved by using GIS tools for planning UGS, as people can get to know the actual ground reality to be achieved.
For adequate UGS planning, the existing green spaces in the city need to be addressed first. The stub semi-natural land with quality vegetation and varied, rich species can produce sound recreational and biodiverse spaces. The choice of vegetation plays a crucial role in determining and enhancing the quality of greens in a space. Choosing a natural species composition that supplements the biodiversity of the area is required. In cities undergoing densification, innovative greening techniques such as green roofs, green walls, street sites, and renaturation are very beneficial to improving green quality [22]. On an architectural scale, green needs to be saved by making effective plans. Also, site trees should not be cut during the construction phase. Proper distribution of UGS within the cities should be ensured to enhance their accessibility and visibility. Efforts to green the city streets should be made using various shrub species in order to improve the overall quality of UGS.
The efficacious planning of city greens can be achieved by utilizing ecological principles such as greenways, green fingers, and green belts. Using these principles aims at availing the optimal use of UGS geometry, thus enhancing their accessibility and diversity. Greenways act as a UGS management tool and are usually developed linearly across cities, contributing effectively to city greens. They are created along roads, railways, rivers and ridges helping to preserve green spaces and bring green vegetation into urban areas. Green fingers are conceptualized in the shape of human fingers and have green spaces set in a radial form spreading from city centre to periphery [23]. They bring green vegetation into the core of settlements and their adjoining areas, enabling citizens easy access to UGS. Green belts are set out to act as a protective mechanism checking the outward growth of cities. They are usually created in a ring form at city outskirts to prevent urban sprawl. They also acted as city boundaries separating one city from another. They contributed mainly to preserving city vegetation by safeguarding peripheral land for agriculture, forestry and recreation.
Within compact, dense cities, the land availability is less and thus, altering greening practices are required to fulfill the cities UGS requirements. In such cases practice of green roofs and walls comes to the rescue. Green roofs are the roof of a building covered with vegetation [19]. They not just provide esthetically pleasing landscapes but also create a habitat for wildlife and lower air temperature and mitigate the urban heat island effect. Providing green roofs increases property value in addition to many other benefits. Green wall, on the other hand, is a vertical greening typology wherein the walls are covered with vegetation. It can be used to enhance green spaces on land by using effective multi-level greenery designs. To encourage more and more people to use green roofs and walls, various policy measures in terms of economic incentives and tax exemption is required. Also, spreading environmental knowledge regarding them will increase the willingness of more people to implement these alternative greening measures.
The end-users of the UGS are city residents, and thus it is essential to involve them in the planning process. Public participation programs need to be thoughtfully planned and provide all the necessary information to the stakeholders. The urban planners and decision makers need to be open-minded and committed to considering the stakeholder’s inputs. To have active participation, the stakeholders need to explain the decision-making process and have a visual presentation clearly. For effective public participation, the demographic structure of the area needs to be identified, and further, the goals for UGS needs to be set accordingly [24]. Developing a questionnaire based on the area profile, demographics and UGS requirements should be formulated. To educate the citizens regarding UGS, workshops, seminars, and expert discussions can be conducted, which will also help the decision makers better identify local needs and demands.
With the rapid urbanization occurring in our cities, the need for sustainable development is more than ever. UGS are significant contributors to sustainable development as they provide us with several ecological services. They assist carbon sequestration, reduce the urban heat island effect, act as a barrier for noise pollution and bring down air pollution. The built environment is majorly affected by the UGS as they comprise recreational spaces for citizens that promote social inclusion in communities. Urban planners play a significant role in the provision of UGS in our cities. They are the primary decision-makers guided by the various standards, policies, laws and legislations. But most of the time, UGS seldomly take a back seat in the planning process over other land use such as residential, commercial, industrial and institutional. Therefore, it is essential for urban planning to address the challenges associated with UGS and suggest various strategies and measures. Indian cities face many challenges with the incredible pace of urbanization, such as less quantity of UGS and inappropriate quality. UGS is not equitably distributed in many cities and is not easily accessible [25]. The intended purpose not being served causes dissatisfaction amongst the city residents. To improve the situation of UGS in our cities, it is utterly vital to improve the planning process and at the same time strengthen the spatial data available to the decision-makers [26]. It is primarily important to work on enhancing the quality of UGS and incorporate various ecological principles available to us in the planning process. In cities undergoing densification and reduced land availability, alternative greening practices such as green roofs and walls can be of great help. Above people are all that avail the UGS, so it’s imperative to involve them in the planning process. It is equally essential for the youth to take this up in their hands of responsibility, and that is only possible if they have been given a chance, ensured support and most importantly, allotted funds for improving the UGS.
IntechOpen aims to ensure that original material is published while at the same time giving significant freedom to our Authors. To that end we maintain a flexible Copyright Policy guaranteeing that there is no transfer of copyright to the publisher and Authors retain exclusive copyright to their Work.
',metaTitle:"Publication Agreement - Chapters",metaDescription:"IN TECH aims to guarantee that original material is published while at the same time giving significant freedom to our authors. For that matter, we uphold a flexible copyright policy meaning that there is no transfer of copyright to the publisher and authors retain exclusive copyright to their work.\n\nWhen submitting a manuscript the Corresponding Author is required to accept the terms and conditions set forth in our Publication Agreement as follows:",metaKeywords:null,canonicalURL:"/page/publication-agreement-chapters",contentRaw:'[{"type":"htmlEditorComponent","content":"The Corresponding Author (acting on behalf of all Authors) and INTECHOPEN LIMITED, incorporated and registered in England and Wales with company number 11086078 and a registered office at 5 Princes Gate Court, London, United Kingdom, SW7 2QJ conclude the following Agreement regarding the publication of a Book Chapter:
\\n\\n1. DEFINITIONS
\\n\\nCorresponding Author: The Author of the Chapter who serves as a Signatory to this Agreement. The Corresponding Author acts on behalf of any other Co-Author.
\\n\\nCo-Author: All other Authors of the Chapter besides the Corresponding Author.
\\n\\nIntechOpen: IntechOpen Ltd., the Publisher of the Book.
\\n\\nBook: The publication as a collection of chapters compiled by IntechOpen including the Chapter. Chapter: The original literary work created by Corresponding Author and any Co-Author that is the subject of this Agreement.
\\n\\n2. CORRESPONDING AUTHOR'S GRANT OF RIGHTS
\\n\\n2.1 Subject to the following Article, the Corresponding Author grants and shall ensure that each Co-Author grants, to IntechOpen, during the full term of copyright and any extensions or renewals of that term the following:
\\n\\nThe aforementioned licenses shall survive the expiry or termination of this Agreement for any reason.
\\n\\n2.2 The Corresponding Author (on their own behalf and on behalf of any Co-Author) reserves the following rights to the Chapter but agrees not to exercise them in such a way as to adversely affect IntechOpen's ability to utilize the full benefit of this Publication Agreement: (i) reprographic rights worldwide, other than those which subsist in the typographical arrangement of the Chapter as published by IntechOpen; and (ii) public lending rights arising under the Public Lending Right Act 1979, as amended from time to time, and any similar rights arising in any part of the world.
\\n\\nThe Corresponding Author confirms that they (and any Co-Author) are and will remain a member of any applicable licensing and collecting society and any successor to that body responsible for administering royalties for the reprographic reproduction of copyright works.
\\n\\nSubject to the license granted above, copyright in the Chapter and all versions of it created during IntechOpen's editing process (including the published version) is retained by the Corresponding Author and any Co-Author.
\\n\\nSubject to the license granted above, the Corresponding Author and any Co-Author retains patent, trademark and other intellectual property rights to the Chapter.
\\n\\n2.3 All rights granted to IntechOpen in this Article are assignable, sublicensable or otherwise transferrable to third parties without the Corresponding Author's or any Co-Author’s specific approval.
\\n\\n2.4 The Corresponding Author (on their own behalf and on behalf of each Co-Author) will not assert any rights under the Copyright, Designs and Patents Act 1988 to object to derogatory treatment of the Chapter as a consequence of IntechOpen's changes to the Chapter arising from translation of it, corrections and edits for house style, removal of problematic material and other reasonable edits.
\\n\\n3. CORRESPONDING AUTHOR'S DUTIES
\\n\\n3.1 When distributing or re-publishing the Chapter, the Corresponding Author agrees to credit the Book in which the Chapter has been published as the source of first publication, as well as IntechOpen. The Corresponding Author warrants that each Co-Author will also credit the Book in which the Chapter has been published as the source of first publication, as well as IntechOpen, when they are distributing or re-publishing the Chapter.
\\n\\n3.2 When submitting the Chapter, the Corresponding Author agrees to:
\\n\\nThe Corresponding Author will be held responsible for the payment of the Open Access Publishing Fees.
\\n\\nAll payments shall be due 30 days from the date of the issued invoice. The Corresponding Author or the payer on the Corresponding Author's and Co-Authors' behalf will bear all banking and similar charges incurred.
\\n\\n3.3 The Corresponding Author shall obtain in writing all consents necessary for the reproduction of any material in which a third-party right exists, including quotations, photographs and illustrations, in all editions of the Chapter worldwide for the full term of the above licenses, and shall provide to IntechOpen upon request the original copies of such consents for inspection (at IntechOpen's option) or photocopies of such consents.
\\n\\nThe Corresponding Author shall obtain written informed consent for publication from people who might recognize themselves or be identified by others (e.g. from case reports or photographs).
\\n\\n3.4 The Corresponding Author and any Co-Author shall respect confidentiality rights during and after the termination of this Agreement. The information contained in all correspondence and documents as part of the publishing activity between IntechOpen and the Corresponding Author and any Co-Author are confidential and are intended only for the recipient. The contents may not be disclosed publicly and are not intended for unauthorized use or distribution. Any use, disclosure, copying, or distribution is prohibited and may be unlawful.
\\n\\n4. CORRESPONDING AUTHOR'S WARRANTY
\\n\\n4.1 The Corresponding Author represents and warrants that the Chapter does not and will not breach any applicable law or the rights of any third party and, specifically, that the Chapter contains no matter that is defamatory or that infringes any literary or proprietary rights, intellectual property rights, or any rights of privacy. The Corresponding Author warrants and represents that: (i) the Chapter is the original work of themselves and any Co-Author and is not copied wholly or substantially from any other work or material or any other source; (ii) the Chapter has not been formally published in any other peer-reviewed journal or in a book or edited collection, and is not under consideration for any such publication; (iii) they themselves and any Co-Author are qualifying persons under section 154 of the Copyright, Designs and Patents Act 1988; (iv) they themselves and any Co-Author have not assigned and will not during the term of this Publication Agreement purport to assign any of the rights granted to IntechOpen under this Publication Agreement; and (v) the rights granted by this Publication Agreement are free from any security interest, option, mortgage, charge or lien.
\\n\\nThe Corresponding Author also warrants and represents that: (i) they have the full power to enter into this Publication Agreement on their own behalf and on behalf of each Co-Author; and (ii) they have the necessary rights and/or title in and to the Chapter to grant IntechOpen, on behalf of themselves and any Co-Author, the rights and licenses expressed to be granted in this Publication Agreement. If the Chapter was prepared jointly by the Corresponding Author and any Co-Author, the Corresponding Author warrants and represents that: (i) each Co-Author agrees to the submission, license and publication of the Chapter on the terms of this Publication Agreement; and (ii) they have the authority to enter into this Publication Agreement on behalf of and bind each Co-Author. The Corresponding Author shall: (i) ensure each Co-Author complies with all relevant provisions of this Publication Agreement, including those relating to confidentiality, performance and standards, as if a party to this Publication Agreement; and (ii) remain primarily liable for all acts and/or omissions of each such Co-Author.
\\n\\nThe Corresponding Author agrees to indemnify and hold IntechOpen harmless against all liabilities, costs, expenses, damages and losses and all reasonable legal costs and expenses suffered or incurred by IntechOpen arising out of or in connection with any breach of the aforementioned representations and warranties. This indemnity shall not cover IntechOpen to the extent that a claim under it results from IntechOpen's negligence or willful misconduct.
\\n\\n4.2 Nothing in this Publication Agreement shall have the effect of excluding or limiting any liability for death or personal injury caused by negligence or any other liability that cannot be excluded or limited by applicable law.
\\n\\n5. TERMINATION
\\n\\n5.1 IntechOpen has a right to terminate this Publication Agreement for quality, program, technical or other reasons with immediate effect, including without limitation (i) if the Corresponding Author or any Co-Author commits a material breach of this Publication Agreement; (ii) if the Corresponding Author or any Co-Author (being an individual) is the subject of a bankruptcy petition, application or order; or (iii) if the Corresponding Author or any Co-Author (being a company) commences negotiations with all or any class of its creditors with a view to rescheduling any of its debts, or makes a proposal for or enters into any compromise or arrangement with any of its creditors.
\\n\\nIn case of termination, IntechOpen will notify the Corresponding Author, in writing, of the decision.
\\n\\n6. INTECHOPEN’S DUTIES AND RIGHTS
\\n\\n6.1 Unless prevented from doing so by events outside its reasonable control, IntechOpen, in its discretion, agrees to publish the Chapter attributing it to the Corresponding Author and any Co-Author.
\\n\\n6.2 IntechOpen has the right to use the Corresponding Author’s and any Co-Author’s names and likeness in connection with scientific dissemination, retrieval, archiving, web hosting and promotion and marketing of the Chapter and has the right to contact the Corresponding Author and any Co-Author until the Chapter is publicly available on any platform owned and/or operated by IntechOpen.
\\n\\n6.3 IntechOpen is granted the authority to enforce the rights from this Publication Agreement, on behalf of the Corresponding Author and any Co-Author, against third parties (for example in cases of plagiarism or copyright infringements). In respect of any such infringement or suspected infringement of the copyright in the Chapter, IntechOpen shall have absolute discretion in addressing any such infringement which is likely to affect IntechOpen's rights under this Publication Agreement, including issuing and conducting proceedings against the suspected infringer.
\\n\\n7. MISCELLANEOUS
\\n\\n7.1 Further Assurance: The Corresponding Author shall and will ensure that any relevant third party (including any Co-Author) shall, execute and deliver whatever further documents or deeds and perform such acts as IntechOpen reasonably requires from time to time for the purpose of giving IntechOpen the full benefit of the provisions of this Publication Agreement.
\\n\\n7.2 Third Party Rights: A person who is not a party to this Publication Agreement may not enforce any of its provisions under the Contracts (Rights of Third Parties) Act 1999.
\\n\\n7.3 Entire Agreement: This Publication Agreement constitutes the entire agreement between the parties in relation to its subject matter. It replaces and extinguishes all prior agreements, draft agreements, arrangements, collateral warranties, collateral contracts, statements, assurances, representations and undertakings of any nature made by or on behalf of the parties, whether oral or written, in relation to that subject matter. Each party acknowledges that in entering into this Publication Agreement it has not relied upon any oral or written statements, collateral or other warranties, assurances, representations or undertakings which were made by or on behalf of the other party in relation to the subject matter of this Publication Agreement at any time before its signature (together "Pre-Contractual Statements"), other than those which are set out in this Publication Agreement. Each party hereby waives all rights and remedies which might otherwise be available to it in relation to such Pre-Contractual Statements. Nothing in this clause shall exclude or restrict the liability of either party arising out of its pre-contract fraudulent misrepresentation or fraudulent concealment.
\\n\\n7.4 Waiver: No failure or delay by a party to exercise any right or remedy provided under this Publication Agreement or by law shall constitute a waiver of that or any other right or remedy, nor shall it preclude or restrict the further exercise of that or any other right or remedy. No single or partial exercise of such right or remedy shall preclude or restrict the further exercise of that or any other right or remedy.
\\n\\n7.5 Variation: No variation of this Publication Agreement shall be effective unless it is in writing and signed by the parties (or their duly authorized representatives).
\\n\\n7.6 Severance: If any provision or part-provision of this Publication Agreement is or becomes invalid, illegal or unenforceable, it shall be deemed modified to the minimum extent necessary to make it valid, legal and enforceable. If such modification is not possible, the relevant provision or part-provision shall be deemed deleted.
\\n\\nAny modification to or deletion of a provision or part-provision under this clause shall not affect the validity and enforceability of the rest of this Publication Agreement.
\\n\\n7.7 No partnership: Nothing in this Publication Agreement is intended to, or shall be deemed to, establish or create any partnership or joint venture or the relationship of principal and agent or employer and employee between IntechOpen and the Corresponding Author or any Co-Author, nor authorize any party to make or enter into any commitments for or on behalf of any other party.
\\n\\n7.8 Governing law: This Publication Agreement and any dispute or claim (including non-contractual disputes or claims) arising out of or in connection with it or its subject matter or formation shall be governed by and construed in accordance with the law of England and Wales. The parties submit to the exclusive jurisdiction of the English courts to settle any dispute or claim arising out of or in connection with this Publication Agreement (including any non-contractual disputes or claims).
\\n\\nLast updated: 2020-11-27
\\n\\n\\n\\n
\\n"}]'},components:[{type:"htmlEditorComponent",content:"
The Corresponding Author (acting on behalf of all Authors) and INTECHOPEN LIMITED, incorporated and registered in England and Wales with company number 11086078 and a registered office at 5 Princes Gate Court, London, United Kingdom, SW7 2QJ conclude the following Agreement regarding the publication of a Book Chapter:
\n\n1. DEFINITIONS
\n\nCorresponding Author: The Author of the Chapter who serves as a Signatory to this Agreement. The Corresponding Author acts on behalf of any other Co-Author.
\n\nCo-Author: All other Authors of the Chapter besides the Corresponding Author.
\n\nIntechOpen: IntechOpen Ltd., the Publisher of the Book.
\n\nBook: The publication as a collection of chapters compiled by IntechOpen including the Chapter. Chapter: The original literary work created by Corresponding Author and any Co-Author that is the subject of this Agreement.
\n\n2. CORRESPONDING AUTHOR'S GRANT OF RIGHTS
\n\n2.1 Subject to the following Article, the Corresponding Author grants and shall ensure that each Co-Author grants, to IntechOpen, during the full term of copyright and any extensions or renewals of that term the following:
\n\nThe aforementioned licenses shall survive the expiry or termination of this Agreement for any reason.
\n\n2.2 The Corresponding Author (on their own behalf and on behalf of any Co-Author) reserves the following rights to the Chapter but agrees not to exercise them in such a way as to adversely affect IntechOpen's ability to utilize the full benefit of this Publication Agreement: (i) reprographic rights worldwide, other than those which subsist in the typographical arrangement of the Chapter as published by IntechOpen; and (ii) public lending rights arising under the Public Lending Right Act 1979, as amended from time to time, and any similar rights arising in any part of the world.
\n\nThe Corresponding Author confirms that they (and any Co-Author) are and will remain a member of any applicable licensing and collecting society and any successor to that body responsible for administering royalties for the reprographic reproduction of copyright works.
\n\nSubject to the license granted above, copyright in the Chapter and all versions of it created during IntechOpen's editing process (including the published version) is retained by the Corresponding Author and any Co-Author.
\n\nSubject to the license granted above, the Corresponding Author and any Co-Author retains patent, trademark and other intellectual property rights to the Chapter.
\n\n2.3 All rights granted to IntechOpen in this Article are assignable, sublicensable or otherwise transferrable to third parties without the Corresponding Author's or any Co-Author’s specific approval.
\n\n2.4 The Corresponding Author (on their own behalf and on behalf of each Co-Author) will not assert any rights under the Copyright, Designs and Patents Act 1988 to object to derogatory treatment of the Chapter as a consequence of IntechOpen's changes to the Chapter arising from translation of it, corrections and edits for house style, removal of problematic material and other reasonable edits.
\n\n3. CORRESPONDING AUTHOR'S DUTIES
\n\n3.1 When distributing or re-publishing the Chapter, the Corresponding Author agrees to credit the Book in which the Chapter has been published as the source of first publication, as well as IntechOpen. The Corresponding Author warrants that each Co-Author will also credit the Book in which the Chapter has been published as the source of first publication, as well as IntechOpen, when they are distributing or re-publishing the Chapter.
\n\n3.2 When submitting the Chapter, the Corresponding Author agrees to:
\n\nThe Corresponding Author will be held responsible for the payment of the Open Access Publishing Fees.
\n\nAll payments shall be due 30 days from the date of the issued invoice. The Corresponding Author or the payer on the Corresponding Author's and Co-Authors' behalf will bear all banking and similar charges incurred.
\n\n3.3 The Corresponding Author shall obtain in writing all consents necessary for the reproduction of any material in which a third-party right exists, including quotations, photographs and illustrations, in all editions of the Chapter worldwide for the full term of the above licenses, and shall provide to IntechOpen upon request the original copies of such consents for inspection (at IntechOpen's option) or photocopies of such consents.
\n\nThe Corresponding Author shall obtain written informed consent for publication from people who might recognize themselves or be identified by others (e.g. from case reports or photographs).
\n\n3.4 The Corresponding Author and any Co-Author shall respect confidentiality rights during and after the termination of this Agreement. The information contained in all correspondence and documents as part of the publishing activity between IntechOpen and the Corresponding Author and any Co-Author are confidential and are intended only for the recipient. The contents may not be disclosed publicly and are not intended for unauthorized use or distribution. Any use, disclosure, copying, or distribution is prohibited and may be unlawful.
\n\n4. CORRESPONDING AUTHOR'S WARRANTY
\n\n4.1 The Corresponding Author represents and warrants that the Chapter does not and will not breach any applicable law or the rights of any third party and, specifically, that the Chapter contains no matter that is defamatory or that infringes any literary or proprietary rights, intellectual property rights, or any rights of privacy. The Corresponding Author warrants and represents that: (i) the Chapter is the original work of themselves and any Co-Author and is not copied wholly or substantially from any other work or material or any other source; (ii) the Chapter has not been formally published in any other peer-reviewed journal or in a book or edited collection, and is not under consideration for any such publication; (iii) they themselves and any Co-Author are qualifying persons under section 154 of the Copyright, Designs and Patents Act 1988; (iv) they themselves and any Co-Author have not assigned and will not during the term of this Publication Agreement purport to assign any of the rights granted to IntechOpen under this Publication Agreement; and (v) the rights granted by this Publication Agreement are free from any security interest, option, mortgage, charge or lien.
\n\nThe Corresponding Author also warrants and represents that: (i) they have the full power to enter into this Publication Agreement on their own behalf and on behalf of each Co-Author; and (ii) they have the necessary rights and/or title in and to the Chapter to grant IntechOpen, on behalf of themselves and any Co-Author, the rights and licenses expressed to be granted in this Publication Agreement. If the Chapter was prepared jointly by the Corresponding Author and any Co-Author, the Corresponding Author warrants and represents that: (i) each Co-Author agrees to the submission, license and publication of the Chapter on the terms of this Publication Agreement; and (ii) they have the authority to enter into this Publication Agreement on behalf of and bind each Co-Author. The Corresponding Author shall: (i) ensure each Co-Author complies with all relevant provisions of this Publication Agreement, including those relating to confidentiality, performance and standards, as if a party to this Publication Agreement; and (ii) remain primarily liable for all acts and/or omissions of each such Co-Author.
\n\nThe Corresponding Author agrees to indemnify and hold IntechOpen harmless against all liabilities, costs, expenses, damages and losses and all reasonable legal costs and expenses suffered or incurred by IntechOpen arising out of or in connection with any breach of the aforementioned representations and warranties. This indemnity shall not cover IntechOpen to the extent that a claim under it results from IntechOpen's negligence or willful misconduct.
\n\n4.2 Nothing in this Publication Agreement shall have the effect of excluding or limiting any liability for death or personal injury caused by negligence or any other liability that cannot be excluded or limited by applicable law.
\n\n5. TERMINATION
\n\n5.1 IntechOpen has a right to terminate this Publication Agreement for quality, program, technical or other reasons with immediate effect, including without limitation (i) if the Corresponding Author or any Co-Author commits a material breach of this Publication Agreement; (ii) if the Corresponding Author or any Co-Author (being an individual) is the subject of a bankruptcy petition, application or order; or (iii) if the Corresponding Author or any Co-Author (being a company) commences negotiations with all or any class of its creditors with a view to rescheduling any of its debts, or makes a proposal for or enters into any compromise or arrangement with any of its creditors.
\n\nIn case of termination, IntechOpen will notify the Corresponding Author, in writing, of the decision.
\n\n6. INTECHOPEN’S DUTIES AND RIGHTS
\n\n6.1 Unless prevented from doing so by events outside its reasonable control, IntechOpen, in its discretion, agrees to publish the Chapter attributing it to the Corresponding Author and any Co-Author.
\n\n6.2 IntechOpen has the right to use the Corresponding Author’s and any Co-Author’s names and likeness in connection with scientific dissemination, retrieval, archiving, web hosting and promotion and marketing of the Chapter and has the right to contact the Corresponding Author and any Co-Author until the Chapter is publicly available on any platform owned and/or operated by IntechOpen.
\n\n6.3 IntechOpen is granted the authority to enforce the rights from this Publication Agreement, on behalf of the Corresponding Author and any Co-Author, against third parties (for example in cases of plagiarism or copyright infringements). In respect of any such infringement or suspected infringement of the copyright in the Chapter, IntechOpen shall have absolute discretion in addressing any such infringement which is likely to affect IntechOpen's rights under this Publication Agreement, including issuing and conducting proceedings against the suspected infringer.
\n\n7. MISCELLANEOUS
\n\n7.1 Further Assurance: The Corresponding Author shall and will ensure that any relevant third party (including any Co-Author) shall, execute and deliver whatever further documents or deeds and perform such acts as IntechOpen reasonably requires from time to time for the purpose of giving IntechOpen the full benefit of the provisions of this Publication Agreement.
\n\n7.2 Third Party Rights: A person who is not a party to this Publication Agreement may not enforce any of its provisions under the Contracts (Rights of Third Parties) Act 1999.
\n\n7.3 Entire Agreement: This Publication Agreement constitutes the entire agreement between the parties in relation to its subject matter. It replaces and extinguishes all prior agreements, draft agreements, arrangements, collateral warranties, collateral contracts, statements, assurances, representations and undertakings of any nature made by or on behalf of the parties, whether oral or written, in relation to that subject matter. Each party acknowledges that in entering into this Publication Agreement it has not relied upon any oral or written statements, collateral or other warranties, assurances, representations or undertakings which were made by or on behalf of the other party in relation to the subject matter of this Publication Agreement at any time before its signature (together "Pre-Contractual Statements"), other than those which are set out in this Publication Agreement. Each party hereby waives all rights and remedies which might otherwise be available to it in relation to such Pre-Contractual Statements. Nothing in this clause shall exclude or restrict the liability of either party arising out of its pre-contract fraudulent misrepresentation or fraudulent concealment.
\n\n7.4 Waiver: No failure or delay by a party to exercise any right or remedy provided under this Publication Agreement or by law shall constitute a waiver of that or any other right or remedy, nor shall it preclude or restrict the further exercise of that or any other right or remedy. No single or partial exercise of such right or remedy shall preclude or restrict the further exercise of that or any other right or remedy.
\n\n7.5 Variation: No variation of this Publication Agreement shall be effective unless it is in writing and signed by the parties (or their duly authorized representatives).
\n\n7.6 Severance: If any provision or part-provision of this Publication Agreement is or becomes invalid, illegal or unenforceable, it shall be deemed modified to the minimum extent necessary to make it valid, legal and enforceable. If such modification is not possible, the relevant provision or part-provision shall be deemed deleted.
\n\nAny modification to or deletion of a provision or part-provision under this clause shall not affect the validity and enforceability of the rest of this Publication Agreement.
\n\n7.7 No partnership: Nothing in this Publication Agreement is intended to, or shall be deemed to, establish or create any partnership or joint venture or the relationship of principal and agent or employer and employee between IntechOpen and the Corresponding Author or any Co-Author, nor authorize any party to make or enter into any commitments for or on behalf of any other party.
\n\n7.8 Governing law: This Publication Agreement and any dispute or claim (including non-contractual disputes or claims) arising out of or in connection with it or its subject matter or formation shall be governed by and construed in accordance with the law of England and Wales. The parties submit to the exclusive jurisdiction of the English courts to settle any dispute or claim arising out of or in connection with this Publication Agreement (including any non-contractual disputes or claims).
\n\nLast updated: 2020-11-27
\n\n\n\n
\n"}]},successStories:{items:[]},authorsAndEditors:{filterParams:{},profiles:[{id:"58592",title:"Dr.",name:"Arun",middleName:null,surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/58592/images/1664_n.jpg",biography:"Arun K. Shanker is serving as a Principal Scientist (Plant Physiology) with the Indian Council of Agricultural Research (ICAR) at the Central Research Institute for Dryland Agriculture in Hyderabad, India. He is working with the ICAR as a full time researcher since 1993 and has since earned his Advanced degree in Crop Physiology while in service. He has been awarded the prestigious Member of the Royal Society of Chemistry (MRSC), by the Royal Society of Chemistry, London in 2015. Presently he is working on systems biology approach to study the mechanism of abiotic stress tolerance in crops. His main focus now is to unravel the mechanism of drought and heat stress response in plants to tackle climate change related threats in agriculture.",institutionString:null,institution:{name:"Indian Council of Agricultural Research",country:{name:"India"}}},{id:"4782",title:"Prof.",name:"Bishnu",middleName:"P",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/4782/images/system/4782.jpg",biography:"Bishnu P. Pal is Professor of Physics at Mahindra École\nCentrale Hyderabad India since July 1st 2014 after retirement\nas Professor of Physics from IIT Delhi; Ph.D.’1975 from IIT\nDelhi; Fellow of OSA and SPIE; Senior Member IEEE;\nHonorary Foreign Member Royal Norwegian Society for\nScience and Arts; Member OSA Board of Directors (2009-\n11); Distinguished Lecturer IEEE Photonics Society (2005-\n07).",institutionString:null,institution:{name:"Indian Institute of Technology Delhi",country:{name:"India"}}},{id:"69653",title:"Dr.",name:"Chusak",middleName:null,surname:"Limsakul",slug:"chusak-limsakul",fullName:"Chusak Limsakul",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Prince of Songkla University",country:{name:"Thailand"}}},{id:"23804",title:"Dr.",name:"Hamzah",middleName:null,surname:"Arof",slug:"hamzah-arof",fullName:"Hamzah Arof",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/23804/images/5492_n.jpg",biography:"Hamzah Arof received his BSc from Michigan State University, and PhD from the University of Wales. Both degrees were in electrical engineering. His current research interests include signal processing and photonics. Currently he is affiliated with the Department of Electrical Engineering, University of Malaya, Malaysia.",institutionString:null,institution:{name:"University of Malaya",country:{name:"Malaysia"}}},{id:"41989",title:"Prof.",name:"He",middleName:null,surname:"Tian",slug:"he-tian",fullName:"He Tian",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"East China University of Science and Technology",country:{name:"China"}}},{id:"33351",title:null,name:"Hendra",middleName:null,surname:"Hermawan",slug:"hendra-hermawan",fullName:"Hendra Hermawan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/33351/images/168_n.jpg",biography:null,institutionString:null,institution:{name:"Institut Teknologi Bandung",country:{name:"Indonesia"}}},{id:"11981",title:"Prof.",name:"Hiroshi",middleName:null,surname:"Ishiguro",slug:"hiroshi-ishiguro",fullName:"Hiroshi Ishiguro",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRglaQAC/Profile_Picture_1626411846553",biography:"Hiroshi Ishiguro is an award-winning roboticist and innovator. As the Director of the Intelligent Robotics Laboratory, which is part of the Department of Systems Innovation in the Graduate School of Engineering Science at Osaka University, Japan, Ishiguro concentrates on making robots that are similar as possible to humans to understand the human species. A notable project of his laboratory is the Actroid, a humanoid robot with a lifelike appearance and observable behavior such as facial movements. (Sources: http://www.geminoid.jp/en/index.html, https://en.wikipedia.org/wiki/Hiroshi_Ishiguro)",institutionString:null,institution:{name:"Osaka University",country:{name:"Japan"}}},{id:"45747",title:"Dr.",name:"Hsin-I",middleName:null,surname:"Chang",slug:"hsin-i-chang",fullName:"Hsin-I Chang",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"National Chiayi University",country:{name:"Taiwan"}}},{id:"61581",title:"Dr.",name:"Joy Rizki Pangestu",middleName:null,surname:"Djuansjah",slug:"joy-rizki-pangestu-djuansjah",fullName:"Joy Rizki Pangestu Djuansjah",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/61581/images/237_n.jpg",biography:null,institutionString:null,institution:{name:"University of Technology Malaysia",country:{name:"Malaysia"}}},{id:"94249",title:"Prof.",name:"Junji",middleName:null,surname:"Kido",slug:"junji-kido",fullName:"Junji Kido",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Yamagata University",country:{name:"Japan"}}},{id:"12009",title:"Dr.",name:"Ki Young",middleName:null,surname:"Kim",slug:"ki-young-kim",fullName:"Ki Young Kim",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/12009/images/system/12009.jpg",biography:"Http://m80.knu.ac.kr/~doors",institutionString:null,institution:{name:"National Cheng Kung University",country:{name:"Taiwan"}}},{id:"132595",title:"Prof.",name:"Long",middleName:null,surname:"Wang",slug:"long-wang",fullName:"Long Wang",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Peking University",country:{name:"China"}}}],filtersByRegion:[{group:"region",caption:"North America",value:1,count:6583},{group:"region",caption:"Middle and South America",value:2,count:5888},{group:"region",caption:"Africa",value:3,count:2381},{group:"region",caption:"Asia",value:4,count:12511},{group:"region",caption:"Australia and Oceania",value:5,count:1006},{group:"region",caption:"Europe",value:6,count:17529}],offset:12,limit:12,total:12514},chapterEmbeded:{data:{}},editorApplication:{success:null,errors:{}},ofsBooks:{filterParams:{hasNoEditors:"0",sort:"dateEndThirdStepPublish",topicId:"56121318"},books:[],filtersByTopic:[{group:"topic",caption:"Agricultural and Biological Sciences",value:5,count:42},{group:"topic",caption:"Biochemistry, Genetics and Molecular Biology",value:6,count:11},{group:"topic",caption:"Business, Management and Economics",value:7,count:6},{group:"topic",caption:"Chemistry",value:8,count:21},{group:"topic",caption:"Computer and Information Science",value:9,count:20},{group:"topic",caption:"Earth and Planetary Sciences",value:10,count:15},{group:"topic",caption:"Engineering",value:11,count:60},{group:"topic",caption:"Environmental Sciences",value:12,count:8},{group:"topic",caption:"Immunology and Microbiology",value:13,count:10},{group:"topic",caption:"Materials Science",value:14,count:27},{group:"topic",caption:"Mathematics",value:15,count:9},{group:"topic",caption:"Medicine",value:16,count:123},{group:"topic",caption:"Nanotechnology and Nanomaterials",value:17,count:9},{group:"topic",caption:"Neuroscience",value:18,count:3},{group:"topic",caption:"Pharmacology, Toxicology and Pharmaceutical Science",value:19,count:7},{group:"topic",caption:"Physics",value:20,count:11},{group:"topic",caption:"Psychology",value:21,count:10},{group:"topic",caption:"Robotics",value:22,count:4},{group:"topic",caption:"Social Sciences",value:23,count:9},{group:"topic",caption:"Veterinary Medicine and Science",value:25,count:4}],offset:12,limit:12,total:0},popularBooks:{featuredBooks:[{type:"book",id:"10584",title:"Engineered Wood Products for Construction",subtitle:null,isOpenForSubmission:!1,hash:"421757c56a3735986055250821275a51",slug:"engineered-wood-products-for-construction",bookSignature:"Meng Gong",coverURL:"https://cdn.intechopen.com/books/images_new/10584.jpg",editors:[{id:"274242",title:"Dr.",name:"Meng",middleName:null,surname:"Gong",slug:"meng-gong",fullName:"Meng Gong"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10222",title:"Demyelination Disorders",subtitle:null,isOpenForSubmission:!1,hash:"b6c26ceccacdde70c41c587361bd5558",slug:"demyelination-disorders",bookSignature:"Stavros J. Baloyannis, Fabian H. Rossi and Welwin Liu",coverURL:"https://cdn.intechopen.com/books/images_new/10222.jpg",editors:[{id:"156098",title:"Emeritus Prof.",name:"Stavros J.",middleName:"J.",surname:"Baloyannis",slug:"stavros-j.-baloyannis",fullName:"Stavros J. Baloyannis"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9544",title:"Global Trade in the Emerging Business Environment",subtitle:null,isOpenForSubmission:!1,hash:"fb8cb09b9599246add78d508a98273d5",slug:"global-trade-in-the-emerging-business-environment",bookSignature:"Muhammad Mohiuddin, Jingbin Wang , Md. Samim Al Azad and Selim Ahmed",coverURL:"https://cdn.intechopen.com/books/images_new/9544.jpg",editors:[{id:"418514",title:"Dr.",name:"Muhammad",middleName:null,surname:"Mohiuddin",slug:"muhammad-mohiuddin",fullName:"Muhammad Mohiuddin"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10979",title:"Parenting",subtitle:"Challenges of Child Rearing in a Changing Society",isOpenForSubmission:!1,hash:"6f345ebcf4fd61e73643c69063a12c7b",slug:"parenting-challenges-of-child-rearing-in-a-changing-society",bookSignature:"Sayyed Ali Samadi",coverURL:"https://cdn.intechopen.com/books/images_new/10979.jpg",editors:[{id:"52145",title:"Dr.",name:"Sayyed Ali",middleName:null,surname:"Samadi",slug:"sayyed-ali-samadi",fullName:"Sayyed Ali Samadi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9808",title:"Contemporary Topics in Patient Safety",subtitle:"Volume 1",isOpenForSubmission:!1,hash:"fb6371607c2c6c02c6a2af8892765aba",slug:"contemporary-topics-in-patient-safety-volume-1",bookSignature:"Stanislaw P. Stawicki and Michael S. Firstenberg",coverURL:"https://cdn.intechopen.com/books/images_new/9808.jpg",editors:[{id:"181694",title:"Dr.",name:"Stanislaw P.",middleName:null,surname:"Stawicki",slug:"stanislaw-p.-stawicki",fullName:"Stanislaw P. Stawicki"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10681",title:"Biodegradation Technology of Organic and Inorganic Pollutants",subtitle:null,isOpenForSubmission:!1,hash:"9a6e10e02788092872fd249436898e97",slug:"biodegradation-technology-of-organic-and-inorganic-pollutants",bookSignature:"Kassio Ferreira Mendes, Rodrigo Nogueira de Sousa and Kamila Cabral Mielke",coverURL:"https://cdn.intechopen.com/books/images_new/10681.jpg",editors:[{id:"197720",title:"Ph.D.",name:"Kassio",middleName:null,surname:"Ferreira Mendes",slug:"kassio-ferreira-mendes",fullName:"Kassio Ferreira Mendes"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10764",title:"Antenna Systems",subtitle:null,isOpenForSubmission:!1,hash:"2fbf1c7a5d92723f08198fc9b526a8ad",slug:"antenna-systems",bookSignature:"Hussain Al-Rizzo and Said Abushamleh",coverURL:"https://cdn.intechopen.com/books/images_new/10764.jpg",editors:[{id:"153384",title:"Prof.",name:"Hussain",middleName:null,surname:"Al-Rizzo",slug:"hussain-al-rizzo",fullName:"Hussain Al-Rizzo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10668",title:"Sustainability of Concrete With Synthetic and Recycled Aggregates",subtitle:null,isOpenForSubmission:!1,hash:"55856c6a8bc3a5b21dae5a1af09a56b6",slug:"sustainability-of-concrete-with-synthetic-and-recycled-aggregates",bookSignature:"Hosam M. Saleh",coverURL:"https://cdn.intechopen.com/books/images_new/10668.jpg",editors:[{id:"144691",title:"Prof.",name:"Hosam",middleName:null,surname:"Saleh",slug:"hosam-saleh",fullName:"Hosam Saleh"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10803",title:"Reactive Oxygen Species",subtitle:null,isOpenForSubmission:!1,hash:"176adcf090fdd1f93cb8ce3146e79ca1",slug:"reactive-oxygen-species",bookSignature:"Rizwan Ahmad",coverURL:"https://cdn.intechopen.com/books/images_new/10803.jpg",editors:[{id:"40482",title:null,name:"Rizwan",middleName:null,surname:"Ahmad",slug:"rizwan-ahmad",fullName:"Rizwan Ahmad"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9032",title:"Corporate Social Responsibility",subtitle:null,isOpenForSubmission:!1,hash:"f609bf3251d7cc7bae0099a4374adfc3",slug:"corporate-social-responsibility",bookSignature:"Beatrice Orlando",coverURL:"https://cdn.intechopen.com/books/images_new/9032.jpg",editors:[{id:"232969",title:"Prof.",name:"Beatrice",middleName:null,surname:"Orlando",slug:"beatrice-orlando",fullName:"Beatrice Orlando"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10351",title:"Enhanced Liposuction",subtitle:"New Perspectives and Techniques",isOpenForSubmission:!1,hash:"f08ed6de16da357614586c5b58ed4dfa",slug:"enhanced-liposuction-new-perspectives-and-techniques",bookSignature:"Diane Irvine Duncan",coverURL:"https://cdn.intechopen.com/books/images_new/10351.jpg",editors:[{id:"279869",title:"Dr.",name:"Diane Irvine",middleName:null,surname:"Duncan",slug:"diane-irvine-duncan",fullName:"Diane Irvine Duncan"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10779",title:"21st Century Nanostructured Materials",subtitle:"Physics, Chemistry, Classification, and Emerging Applications in Industry, Biomedicine, and Agriculture",isOpenForSubmission:!1,hash:"72c67f97f9bef68200df115b5fd79884",slug:"21st-century-nanostructured-materials-physics-chemistry-classification-and-emerging-applications-in-industry-biomedicine-and-agriculture",bookSignature:"Phuong V. Pham",coverURL:"https://cdn.intechopen.com/books/images_new/10779.jpg",editors:[{id:"236073",title:"Dr.",name:"Phuong",middleName:"Viet",surname:"Pham",slug:"phuong-pham",fullName:"Phuong Pham"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],offset:12,limit:12,total:4386},hotBookTopics:{hotBooks:[],offset:0,limit:12,total:null},publish:{},publishingProposal:{success:null,errors:{}},books:{featuredBooks:[{type:"book",id:"10584",title:"Engineered Wood Products for Construction",subtitle:null,isOpenForSubmission:!1,hash:"421757c56a3735986055250821275a51",slug:"engineered-wood-products-for-construction",bookSignature:"Meng Gong",coverURL:"https://cdn.intechopen.com/books/images_new/10584.jpg",publishedDate:"April 28th 2022",numberOfDownloads:3665,editors:[{id:"274242",title:"Dr.",name:"Meng",middleName:null,surname:"Gong",slug:"meng-gong",fullName:"Meng Gong"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10222",title:"Demyelination Disorders",subtitle:null,isOpenForSubmission:!1,hash:"b6c26ceccacdde70c41c587361bd5558",slug:"demyelination-disorders",bookSignature:"Stavros J. Baloyannis, Fabian H. Rossi and Welwin Liu",coverURL:"https://cdn.intechopen.com/books/images_new/10222.jpg",publishedDate:"May 4th 2022",numberOfDownloads:1713,editors:[{id:"156098",title:"Emeritus Prof.",name:"Stavros J.",middleName:"J.",surname:"Baloyannis",slug:"stavros-j.-baloyannis",fullName:"Stavros J. Baloyannis"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9544",title:"Global Trade in the Emerging Business Environment",subtitle:null,isOpenForSubmission:!1,hash:"fb8cb09b9599246add78d508a98273d5",slug:"global-trade-in-the-emerging-business-environment",bookSignature:"Muhammad Mohiuddin, Jingbin Wang , Md. Samim Al Azad and Selim Ahmed",coverURL:"https://cdn.intechopen.com/books/images_new/9544.jpg",publishedDate:"April 28th 2022",numberOfDownloads:2481,editors:[{id:"418514",title:"Dr.",name:"Muhammad",middleName:null,surname:"Mohiuddin",slug:"muhammad-mohiuddin",fullName:"Muhammad Mohiuddin"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10979",title:"Parenting",subtitle:"Challenges of Child Rearing in a Changing Society",isOpenForSubmission:!1,hash:"6f345ebcf4fd61e73643c69063a12c7b",slug:"parenting-challenges-of-child-rearing-in-a-changing-society",bookSignature:"Sayyed Ali Samadi",coverURL:"https://cdn.intechopen.com/books/images_new/10979.jpg",publishedDate:"May 4th 2022",numberOfDownloads:1107,editors:[{id:"52145",title:"Dr.",name:"Sayyed Ali",middleName:null,surname:"Samadi",slug:"sayyed-ali-samadi",fullName:"Sayyed Ali Samadi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9808",title:"Contemporary Topics in Patient Safety",subtitle:"Volume 1",isOpenForSubmission:!1,hash:"fb6371607c2c6c02c6a2af8892765aba",slug:"contemporary-topics-in-patient-safety-volume-1",bookSignature:"Stanislaw P. Stawicki and Michael S. Firstenberg",coverURL:"https://cdn.intechopen.com/books/images_new/9808.jpg",publishedDate:"April 20th 2022",numberOfDownloads:3307,editors:[{id:"181694",title:"Dr.",name:"Stanislaw P.",middleName:null,surname:"Stawicki",slug:"stanislaw-p.-stawicki",fullName:"Stanislaw P. Stawicki"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10681",title:"Biodegradation Technology of Organic and Inorganic Pollutants",subtitle:null,isOpenForSubmission:!1,hash:"9a6e10e02788092872fd249436898e97",slug:"biodegradation-technology-of-organic-and-inorganic-pollutants",bookSignature:"Kassio Ferreira Mendes, Rodrigo Nogueira de Sousa and Kamila Cabral Mielke",coverURL:"https://cdn.intechopen.com/books/images_new/10681.jpg",publishedDate:"April 20th 2022",numberOfDownloads:3266,editors:[{id:"197720",title:"Ph.D.",name:"Kassio",middleName:null,surname:"Ferreira Mendes",slug:"kassio-ferreira-mendes",fullName:"Kassio Ferreira Mendes"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10764",title:"Antenna Systems",subtitle:null,isOpenForSubmission:!1,hash:"2fbf1c7a5d92723f08198fc9b526a8ad",slug:"antenna-systems",bookSignature:"Hussain Al-Rizzo and Said Abushamleh",coverURL:"https://cdn.intechopen.com/books/images_new/10764.jpg",publishedDate:"April 28th 2022",numberOfDownloads:1868,editors:[{id:"153384",title:"Prof.",name:"Hussain",middleName:null,surname:"Al-Rizzo",slug:"hussain-al-rizzo",fullName:"Hussain Al-Rizzo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10668",title:"Sustainability of Concrete With Synthetic and Recycled Aggregates",subtitle:null,isOpenForSubmission:!1,hash:"55856c6a8bc3a5b21dae5a1af09a56b6",slug:"sustainability-of-concrete-with-synthetic-and-recycled-aggregates",bookSignature:"Hosam M. Saleh",coverURL:"https://cdn.intechopen.com/books/images_new/10668.jpg",publishedDate:"May 4th 2022",numberOfDownloads:856,editors:[{id:"144691",title:"Prof.",name:"Hosam",middleName:null,surname:"Saleh",slug:"hosam-saleh",fullName:"Hosam Saleh"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10803",title:"Reactive Oxygen Species",subtitle:null,isOpenForSubmission:!1,hash:"176adcf090fdd1f93cb8ce3146e79ca1",slug:"reactive-oxygen-species",bookSignature:"Rizwan Ahmad",coverURL:"https://cdn.intechopen.com/books/images_new/10803.jpg",publishedDate:"April 28th 2022",numberOfDownloads:1704,editors:[{id:"40482",title:null,name:"Rizwan",middleName:null,surname:"Ahmad",slug:"rizwan-ahmad",fullName:"Rizwan Ahmad"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9032",title:"Corporate Social Responsibility",subtitle:null,isOpenForSubmission:!1,hash:"f609bf3251d7cc7bae0099a4374adfc3",slug:"corporate-social-responsibility",bookSignature:"Beatrice Orlando",coverURL:"https://cdn.intechopen.com/books/images_new/9032.jpg",publishedDate:"March 16th 2022",numberOfDownloads:7489,editors:[{id:"232969",title:"Prof.",name:"Beatrice",middleName:null,surname:"Orlando",slug:"beatrice-orlando",fullName:"Beatrice Orlando"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],latestBooks:[{type:"book",id:"8737",title:"Rabies Virus at the Beginning of 21st Century",subtitle:null,isOpenForSubmission:!1,hash:"49cce3f548da548c718c865feb343509",slug:"rabies-virus-at-the-beginning-of-21st-century",bookSignature:"Sergey Tkachev",coverURL:"https://cdn.intechopen.com/books/images_new/8737.jpg",editedByType:"Edited by",publishedDate:"May 11th 2022",editors:[{id:"61139",title:"Dr.",name:"Sergey",middleName:null,surname:"Tkachev",slug:"sergey-tkachev",fullName:"Sergey Tkachev"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10861",title:"Furan Derivatives",subtitle:"Recent Advances and Applications",isOpenForSubmission:!1,hash:"fdfc39cecd82f91b0effac994f75c877",slug:"furan-derivatives-recent-advances-and-applications",bookSignature:"Anish Khan, Mohammed Muzibur Rahman, M. Ramesh, Salman Ahmad Khan and Abdullah Mohammed Ahmed Asiri",coverURL:"https://cdn.intechopen.com/books/images_new/10861.jpg",editedByType:"Edited by",publishedDate:"May 11th 2022",editors:[{id:"293058",title:"Dr.",name:"Anish",middleName:null,surname:"Khan",slug:"anish-khan",fullName:"Anish Khan"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10356",title:"Natural Medicinal Plants",subtitle:null,isOpenForSubmission:!1,hash:"943e56ccaaf19ff696d25aa638ae37d6",slug:"natural-medicinal-plants",bookSignature:"Hany A. El-Shemy",coverURL:"https://cdn.intechopen.com/books/images_new/10356.jpg",editedByType:"Edited by",publishedDate:"May 11th 2022",editors:[{id:"54719",title:"Prof.",name:"Hany",middleName:null,surname:"El-Shemy",slug:"hany-el-shemy",fullName:"Hany El-Shemy"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10870",title:"Ultrasound Imaging",subtitle:"Current Topics",isOpenForSubmission:!1,hash:"2f0bc3733ab226d67fa73759ef0e12ad",slug:"ultrasound-imaging-current-topics",bookSignature:"Felix Okechukwu Erondu",coverURL:"https://cdn.intechopen.com/books/images_new/10870.jpg",editedByType:"Edited by",publishedDate:"May 11th 2022",editors:[{id:"68312",title:"Prof.",name:"Felix",middleName:null,surname:"Okechukwu Erondu",slug:"felix-okechukwu-erondu",fullName:"Felix Okechukwu Erondu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11392",title:"Leadership in a Changing World",subtitle:"A Multidimensional Perspective",isOpenForSubmission:!1,hash:"86a6d33cf601587e591064ce92effc02",slug:"leadership-in-a-changing-world-a-multidimensional-perspective",bookSignature:"Muhammad Mohiuddin, Bilal Khalid, Md. Samim Al Azad and Slimane Ed-dafali",coverURL:"https://cdn.intechopen.com/books/images_new/11392.jpg",editedByType:"Edited by",publishedDate:"May 11th 2022",editors:[{id:"418514",title:"Dr.",name:"Muhammad",middleName:null,surname:"Mohiuddin",slug:"muhammad-mohiuddin",fullName:"Muhammad Mohiuddin"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10400",title:"The Application of Ant Colony Optimization",subtitle:null,isOpenForSubmission:!1,hash:"f4fdfd07ee1ab99fb7c740d6d0c144c6",slug:"the-application-of-ant-colony-optimization",bookSignature:"Ali Soofastaei",coverURL:"https://cdn.intechopen.com/books/images_new/10400.jpg",editedByType:"Edited by",publishedDate:"May 11th 2022",editors:[{id:"257455",title:"Dr.",name:"Ali",middleName:null,surname:"Soofastaei",slug:"ali-soofastaei",fullName:"Ali Soofastaei"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10915",title:"Leadership",subtitle:"New Insights",isOpenForSubmission:!1,hash:"0d72e79892f2a020cee66a52d09de5a4",slug:"leadership-new-insights",bookSignature:"Mário Franco",coverURL:"https://cdn.intechopen.com/books/images_new/10915.jpg",editedByType:"Edited by",publishedDate:"May 11th 2022",editors:[{id:"105529",title:"Dr.",name:"Mário",middleName:null,surname:"Franco",slug:"mario-franco",fullName:"Mário Franco"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10683",title:"Technological Innovations and Advances in Hydropower Engineering",subtitle:null,isOpenForSubmission:!1,hash:"7ce7ad8768bd2cad155470fe1fd883f4",slug:"technological-innovations-and-advances-in-hydropower-engineering",bookSignature:"Yizi Shang, Ling Shang and Xiaofei Li",coverURL:"https://cdn.intechopen.com/books/images_new/10683.jpg",editedByType:"Edited by",publishedDate:"May 11th 2022",editors:[{id:"349630",title:"Dr.",name:"Yizi",middleName:null,surname:"Shang",slug:"yizi-shang",fullName:"Yizi Shang"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7102",title:"Pneumonia",subtitle:null,isOpenForSubmission:!1,hash:"9fd70142814192dcec58a176749f1b60",slug:"pneumonia",bookSignature:"Nima Rezaei",coverURL:"https://cdn.intechopen.com/books/images_new/7102.jpg",editedByType:"Edited by",publishedDate:"May 11th 2022",editors:[{id:"116250",title:"Dr.",name:"Nima",middleName:null,surname:"Rezaei",slug:"nima-rezaei",fullName:"Nima Rezaei"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9670",title:"Current Trends in Wheat Research",subtitle:null,isOpenForSubmission:!1,hash:"89d795987f1747a76eee532700d2093d",slug:"current-trends-in-wheat-research",bookSignature:"Mahmood-ur-Rahman Ansari",coverURL:"https://cdn.intechopen.com/books/images_new/9670.jpg",editedByType:"Edited by",publishedDate:"May 11th 2022",editors:[{id:"185476",title:"Dr.",name:"Mahmood-ur-Rahman",middleName:null,surname:"Ansari",slug:"mahmood-ur-rahman-ansari",fullName:"Mahmood-ur-Rahman Ansari"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},subject:{topic:{id:"14",title:"Materials Science",slug:"materials-science",parent:{id:"1",title:"Physical Sciences, Engineering and Technology",slug:"physical-sciences-engineering-and-technology"},numberOfBooks:313,numberOfSeries:0,numberOfAuthorsAndEditors:8099,numberOfWosCitations:17602,numberOfCrossrefCitations:8509,numberOfDimensionsCitations:20284,videoUrl:null,fallbackUrl:null,description:null},booksByTopicFilter:{topicId:"14",sort:"-publishedDate",limit:12,offset:0},booksByTopicCollection:[{type:"book",id:"10942",title:"Fiber-Reinforced Plastics",subtitle:null,isOpenForSubmission:!1,hash:"50dc791b1036b236a6676986cb295c6f",slug:"fiber-reinforced-plastics",bookSignature:"Martin Alberto Masuelli",coverURL:"https://cdn.intechopen.com/books/images_new/10942.jpg",editedByType:"Edited by",editors:[{id:"99994",title:"Dr.",name:"Martin",middleName:"Alberto",surname:"Masuelli",slug:"martin-masuelli",fullName:"Martin Masuelli"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10489",title:"Biocomposites",subtitle:null,isOpenForSubmission:!1,hash:"c794533fcae9dcea38672f814ae182db",slug:"biocomposites",bookSignature:"Brajesh Kumar",coverURL:"https://cdn.intechopen.com/books/images_new/10489.jpg",editedByType:"Edited by",editors:[{id:"176093",title:"Dr.",name:"Brajesh",middleName:null,surname:"Kumar",slug:"brajesh-kumar",fullName:"Brajesh Kumar"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9926",title:"Magnesium Alloys Structure and Properties",subtitle:null,isOpenForSubmission:!1,hash:"a6d1a99f4befe885857743f77e81524c",slug:"magnesium-alloys-structure-and-properties",bookSignature:"Tomasz Tański and Paweł Jarka",coverURL:"https://cdn.intechopen.com/books/images_new/9926.jpg",editedByType:"Edited by",editors:[{id:"15700",title:"Prof.",name:"Tomasz Arkadiusz",middleName:null,surname:"Tański",slug:"tomasz-arkadiusz-tanski",fullName:"Tomasz Arkadiusz Tański"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10700",title:"Titanium Dioxide",subtitle:"Advances and Applications",isOpenForSubmission:!1,hash:"d9448d83caa34d90fd58464268c869a0",slug:"titanium-dioxide-advances-and-applications",bookSignature:"Hafiz Muhammad Ali",coverURL:"https://cdn.intechopen.com/books/images_new/10700.jpg",editedByType:"Edited by",editors:[{id:"187624",title:"Dr.",name:"Hafiz Muhammad",middleName:null,surname:"Ali",slug:"hafiz-muhammad-ali",fullName:"Hafiz Muhammad Ali"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6832",title:"Ruthenium",subtitle:"An Element Loved by Researchers",isOpenForSubmission:!1,hash:"9a3be4dd6035f78add07d239b8eae379",slug:"ruthenium-an-element-loved-by-researchers",bookSignature:"Hitoshi Ishida",coverURL:"https://cdn.intechopen.com/books/images_new/6832.jpg",editedByType:"Edited by",editors:[{id:"210140",title:"Dr.",name:"Hitoshi",middleName:null,surname:"Ishida",slug:"hitoshi-ishida",fullName:"Hitoshi Ishida"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10670",title:"Properties and Applications of Alginates",subtitle:null,isOpenForSubmission:!1,hash:"062083e53cc5c808af597de6426cea06",slug:"properties-and-applications-of-alginates",bookSignature:"Irem Deniz, Esra Imamoglu and Tugba Keskin-Gundogdu",coverURL:"https://cdn.intechopen.com/books/images_new/10670.jpg",editedByType:"Edited by",editors:[{id:"204855",title:"Dr.",name:"Irem",middleName:null,surname:"Deniz",slug:"irem-deniz",fullName:"Irem Deniz"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10552",title:"Montmorillonite Clay",subtitle:null,isOpenForSubmission:!1,hash:"c4a279761f0bb046af95ecd32ab09e51",slug:"montmorillonite-clay",bookSignature:"Faheem Uddin",coverURL:"https://cdn.intechopen.com/books/images_new/10552.jpg",editedByType:"Edited by",editors:[{id:"228107",title:"Prof.",name:"Faheem",middleName:null,surname:"Uddin",slug:"faheem-uddin",fullName:"Faheem Uddin"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10949",title:"Clay and Clay Minerals",subtitle:null,isOpenForSubmission:!1,hash:"44d08b9e490617fcbf7786c381c85fbc",slug:"clay-and-clay-minerals",bookSignature:"Gustavo Morari Do Nascimento",coverURL:"https://cdn.intechopen.com/books/images_new/10949.jpg",editedByType:"Edited by",editors:[{id:"7153",title:"Prof.",name:"Gustavo",middleName:null,surname:"Morari Do Nascimento",slug:"gustavo-morari-do-nascimento",fullName:"Gustavo Morari Do Nascimento"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10941",title:"Ferrites",subtitle:"Synthesis and Applications",isOpenForSubmission:!1,hash:"f6a323bfa4565d7c676bc3733b4983b0",slug:"ferrites-synthesis-and-applications",bookSignature:"Maaz Khan",coverURL:"https://cdn.intechopen.com/books/images_new/10941.jpg",editedByType:"Edited by",editors:[{id:"107765",title:"Dr.",name:"Maaz",middleName:null,surname:"Khan",slug:"maaz-khan",fullName:"Maaz Khan"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10014",title:"Thin Films",subtitle:null,isOpenForSubmission:!1,hash:"f56a9427ff53d989f007df97f6ad873c",slug:"thin-films",bookSignature:"Alicia Esther Ares",coverURL:"https://cdn.intechopen.com/books/images_new/10014.jpg",editedByType:"Edited by",editors:[{id:"91095",title:"Dr.",name:"Alicia Esther",middleName:null,surname:"Ares",slug:"alicia-esther-ares",fullName:"Alicia Esther Ares"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10388",title:"Heavy Metals",subtitle:"Their Environmental Impacts and Mitigation",isOpenForSubmission:!1,hash:"ac4f5b254442e9f19a8c609453a83915",slug:"heavy-metals-their-environmental-impacts-and-mitigation",bookSignature:"Mazen Khaled Nazal and Hongbo Zhao",coverURL:"https://cdn.intechopen.com/books/images_new/10388.jpg",editedByType:"Edited by",editors:[{id:"214815",title:"Dr.",name:"Mazen",middleName:null,surname:"Nazal",slug:"mazen-nazal",fullName:"Mazen Nazal"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8018",title:"Extracellular Matrix",subtitle:"Developments and Therapeutics",isOpenForSubmission:!1,hash:"c85e82851e80b40282ff9be99ddf2046",slug:"extracellular-matrix-developments-and-therapeutics",bookSignature:"Rama Sashank Madhurapantula, Joseph Orgel P.R.O. and Zvi Loewy",coverURL:"https://cdn.intechopen.com/books/images_new/8018.jpg",editedByType:"Edited by",editors:[{id:"212416",title:"Dr.",name:"Rama Sashank",middleName:null,surname:"Madhurapantula",slug:"rama-sashank-madhurapantula",fullName:"Rama Sashank Madhurapantula"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],booksByTopicTotal:313,seriesByTopicCollection:[],seriesByTopicTotal:0,mostCitedChapters:[{id:"37067",doi:"10.5772/35482",title:"Fourier Transform Infrared Spectroscopy for Natural Fibres",slug:"fourier-transform-infrared-spectroscopy-for-natural-fibres",totalDownloads:9206,totalCrossrefCites:160,totalDimensionsCites:384,abstract:null,book:{id:"2270",slug:"fourier-transform-materials-analysis",title:"Fourier Transform",fullTitle:"Fourier Transform - Materials Analysis"},signatures:"Mizi Fan, Dasong Dai and Biao Huang",authors:[{id:"104647",title:"Prof.",name:"Mizi",middleName:null,surname:"Fan",slug:"mizi-fan",fullName:"Mizi Fan"}]},{id:"60680",doi:"10.5772/intechopen.76082",title:"Environmental Contamination by Heavy Metals",slug:"environmental-contamination-by-heavy-metals",totalDownloads:15971,totalCrossrefCites:163,totalDimensionsCites:356,abstract:"The environment and its compartments have been severely polluted by heavy metals. This has compromised the ability of the environment to foster life and render its intrinsic values. Heavy metals are known to be naturally occurring compounds, but anthropogenic activities introduce them in large quantities in different environmental compartments. This leads to the environment’s ability to foster life being reduced as human, animal, and plant health become threatened. This occurs due to bioaccumulation in the food chains as a result of the nondegradable state of the heavy metals. Remediation of heavy metals requires special attention to protect soil quality, air quality, water quality, human health, animal health, and all spheres as a collection. Developed physical and chemical heavy metal remediation technologies are demanding costs which are not feasible, time-consuming, and release additional waste to the environment. This chapter summarises the problems related to heavy metal pollution and various remediation technologies. A case study in South Africa mines were also used.",book:{id:"6534",slug:"heavy-metals",title:"Heavy Metals",fullTitle:"Heavy Metals"},signatures:"Vhahangwele Masindi and Khathutshelo L. Muedi",authors:[{id:"225304",title:"Dr.",name:"Vhahangwele",middleName:null,surname:"Masindi",slug:"vhahangwele-masindi",fullName:"Vhahangwele Masindi"},{id:"241403",title:"M.Sc.",name:"Khathutshelo",middleName:"Lilith",surname:"Muedi",slug:"khathutshelo-muedi",fullName:"Khathutshelo Muedi"}]},{id:"42566",doi:"10.5772/53706",title:"Challenges and Opportunities for Spark Plasma Sintering: A Key Technology for a New Generation of Materials",slug:"challenges-and-opportunities-for-spark-plasma-sintering-a-key-technology-for-a-new-generation-of-mat",totalDownloads:9109,totalCrossrefCites:97,totalDimensionsCites:207,abstract:null,book:{id:"3478",slug:"sintering-applications",title:"Sintering Applications",fullTitle:"Sintering Applications"},signatures:"M. Suárez, A. Fernández, J.L. Menéndez, R. Torrecillas, H. U. Kessel, J. Hennicke, R. Kirchner and T. Kessel",authors:[{id:"102383",title:"Dr.",name:"Marta",middleName:null,surname:"Suárez",slug:"marta-suarez",fullName:"Marta Suárez"},{id:"103822",title:"Dr.",name:"J.L",middleName:null,surname:"Menendez",slug:"j.l-menendez",fullName:"J.L Menendez"},{id:"103833",title:"Prof.",name:"Ramón",middleName:null,surname:"Torrecillas",slug:"ramon-torrecillas",fullName:"Ramón Torrecillas"},{id:"162633",title:"Dr.",name:"Adolfo",middleName:null,surname:"Fernández",slug:"adolfo-fernandez",fullName:"Adolfo Fernández"}]},{id:"23617",doi:"10.5772/24118",title:"Collagen- vs. Gelatine-Based Biomaterials and Their Biocompatibility: Review and Perspectives",slug:"collagen-vs-gelatine-based-biomaterials-and-their-biocompatibility-review-and-perspectives",totalDownloads:9373,totalCrossrefCites:60,totalDimensionsCites:196,abstract:null,book:{id:"1487",slug:"biomaterials-applications-for-nanomedicine",title:"Biomaterials",fullTitle:"Biomaterials Applications for Nanomedicine"},signatures:"Selestina Gorgieva and Vanja Kokol",authors:[{id:"55577",title:"Prof.",name:"Vanja",middleName:null,surname:"Kokol",slug:"vanja-kokol",fullName:"Vanja Kokol"},{id:"61285",title:"BSc",name:"Selestina",middleName:null,surname:"Gorgieva",slug:"selestina-gorgieva",fullName:"Selestina Gorgieva"}]},{id:"46243",doi:"10.5772/57255",title:"Corrosion Inhibitors – Principles, Mechanisms and Applications",slug:"corrosion-inhibitors-principles-mechanisms-and-applications",totalDownloads:13621,totalCrossrefCites:40,totalDimensionsCites:156,abstract:null,book:{id:"3817",slug:"developments-in-corrosion-protection",title:"Developments in Corrosion Protection",fullTitle:"Developments in Corrosion Protection"},signatures:"Camila G. Dariva and Alexandre F. Galio",authors:[{id:"169261",title:"Dr.",name:"Camila",middleName:"G.",surname:"Dariva",slug:"camila-dariva",fullName:"Camila Dariva"},{id:"170138",title:"Dr.",name:"Alexandre",middleName:"Ferreira",surname:"Galio",slug:"alexandre-galio",fullName:"Alexandre Galio"}]}],mostDownloadedChaptersLast30Days:[{id:"76780",title:"Basics of Clay Minerals and Their Characteristic Properties",slug:"basics-of-clay-minerals-and-their-characteristic-properties",totalDownloads:1553,totalCrossrefCites:8,totalDimensionsCites:11,abstract:"Clay minerals such as kaolinite, smectite, chlorite, micas are main components of raw materials of clay and formed in presence of water. A large number of clays used to form the different structure which completely depends on their mining source. They are known as hydrous phyllosilicate having silica, alumina and water with variable amount of inorganic ions like Mg2+, Na+, Ca2+ which are found either in interlayer space or on the planetary surface. Clay minerals are described by presence of two-dimensional sheets, tetrahedral (SiO4) and octahedral (Al2O3). There are different clay minerals which are categorized based on presence of tetrahedral and octahedral layer in their structure like kaolinite (1:1 of tetrahedral and octahedral layers), smectite group of clay minerals (2:1 of tetrahedral and octahedral layers) and chlorite (2:1:1 of tetrahedral, octahedral and octahedral layers). The particle size of clay minerals is <2microns which can be present in form of plastic in presence of water and solidified when dried. The small size and their distinctive crystal structure make clay minerals very special with their unique properties including high cation exchange capacity, swelling behavior, specific surface area, adsorption capacity, etc. which are described in this chapter. Due to all these unique properties, clay minerals are gaining interest in different fields.",book:{id:"10949",slug:"clay-and-clay-minerals",title:"Clay and Clay Minerals",fullTitle:"Clay and Clay Minerals"},signatures:"Neeraj Kumari and Chandra Mohan",authors:[{id:"258132",title:"Dr.",name:"Chandra",middleName:null,surname:"Mohan",slug:"chandra-mohan",fullName:"Chandra Mohan"},{id:"352399",title:"Dr.",name:"Neeraj",middleName:null,surname:"Kumari",slug:"neeraj-kumari",fullName:"Neeraj Kumari"}]},{id:"51535",title:"An Introduction to Hydrogels and Some Recent Applications",slug:"an-introduction-to-hydrogels-and-some-recent-applications",totalDownloads:11460,totalCrossrefCites:61,totalDimensionsCites:125,abstract:"Hydrogels have existed for more than half a century, and today they have many applications in various processes ranging from industrial to biological. There are numerous original papers, reviews, and monographs focused on the synthesis, properties, and applications of hydrogels. This chapter covers the fundamental aspects and several applications of hydrogels based on the old and the most recent publications in this field.",book:{id:"5251",slug:"emerging-concepts-in-analysis-and-applications-of-hydrogels",title:"Emerging Concepts in Analysis and Applications of Hydrogels",fullTitle:"Emerging Concepts in Analysis and Applications of Hydrogels"},signatures:"Morteza Bahram, Naimeh Mohseni and Mehdi Moghtader",authors:[{id:"179718",title:"Prof.",name:"Morteza",middleName:null,surname:"Bahram",slug:"morteza-bahram",fullName:"Morteza Bahram"},{id:"185713",title:"Dr.",name:"Naimeh",middleName:null,surname:"Mohseni",slug:"naimeh-mohseni",fullName:"Naimeh Mohseni"},{id:"185714",title:"Dr.",name:"Mehdi",middleName:null,surname:"Moghtader",slug:"mehdi-moghtader",fullName:"Mehdi Moghtader"}]},{id:"70661",title:"Bioremediation Techniques for Polluted Environment: Concept, Advantages, Limitations, and Prospects",slug:"bioremediation-techniques-for-polluted-environment-concept-advantages-limitations-and-prospects",totalDownloads:2409,totalCrossrefCites:6,totalDimensionsCites:18,abstract:"Environmental pollution has been rising in the past few decades due to increased anthropogenic activities. Bioremediation is an attractive and successful cleaning technique to remove toxic waste from polluted environment. Bioremediation is highly involved in degradation, eradication, immobilization, or detoxification diverse chemical wastes and physical hazardous materials from the surrounding through the all-inclusive and action of microorganisms. The main principle is degrading and converting pollutants to less toxic forms. Bioremediation can be carried out ex-situ and in-situ, depending on several factors, which include but not limited to cost, site characteristics, type, and concentration of pollutants. Hence, appropriate bioremediation technique is selected. Additionally, the major methodologies to develop bioremediation are biostimulation, bioaugmentation, bioventing, biopiles, and bioattenuation provided the environmental factors that decide the completion of bioremediation. Bioremediation is the most effective, economical, eco-friendly management tool to manage the polluted environment. All bioremediation techniques have its own advantage and disadvantage because it has its own specific applications.",book:{id:"9343",slug:"trace-metals-in-the-environment-new-approaches-and-recent-advances",title:"Trace Metals in the Environment",fullTitle:"Trace Metals in the Environment - New Approaches and Recent Advances"},signatures:"Indu Sharma",authors:[{id:"301262",title:"Associate Prof.",name:"Indu",middleName:null,surname:"Sharma",slug:"indu-sharma",fullName:"Indu Sharma"}]},{id:"18275",title:"Modeling and Identification of Parameters the Piezoelectric Transducers in Ultrasonic Systems",slug:"modeling-and-identification-of-parameters-the-piezoelectric-transducers-in-ultrasonic-systems",totalDownloads:9936,totalCrossrefCites:3,totalDimensionsCites:5,abstract:null,book:{id:"201",slug:"advances-in-ceramics-electric-and-magnetic-ceramics-bioceramics-ceramics-and-environment",title:"Advances in Ceramics",fullTitle:"Advances in Ceramics - Electric and Magnetic Ceramics, Bioceramics, Ceramics and Environment"},signatures:"Pawel Fabijanski and Ryszard Lagoda",authors:[{id:"13086",title:"Dr.",name:"Pawel",middleName:null,surname:"Fabijański",slug:"pawel-fabijanski",fullName:"Pawel Fabijański"}]},{id:"60680",title:"Environmental Contamination by Heavy Metals",slug:"environmental-contamination-by-heavy-metals",totalDownloads:15997,totalCrossrefCites:164,totalDimensionsCites:356,abstract:"The environment and its compartments have been severely polluted by heavy metals. This has compromised the ability of the environment to foster life and render its intrinsic values. Heavy metals are known to be naturally occurring compounds, but anthropogenic activities introduce them in large quantities in different environmental compartments. This leads to the environment’s ability to foster life being reduced as human, animal, and plant health become threatened. This occurs due to bioaccumulation in the food chains as a result of the nondegradable state of the heavy metals. Remediation of heavy metals requires special attention to protect soil quality, air quality, water quality, human health, animal health, and all spheres as a collection. Developed physical and chemical heavy metal remediation technologies are demanding costs which are not feasible, time-consuming, and release additional waste to the environment. This chapter summarises the problems related to heavy metal pollution and various remediation technologies. A case study in South Africa mines were also used.",book:{id:"6534",slug:"heavy-metals",title:"Heavy Metals",fullTitle:"Heavy Metals"},signatures:"Vhahangwele Masindi and Khathutshelo L. Muedi",authors:[{id:"225304",title:"Dr.",name:"Vhahangwele",middleName:null,surname:"Masindi",slug:"vhahangwele-masindi",fullName:"Vhahangwele Masindi"},{id:"241403",title:"M.Sc.",name:"Khathutshelo",middleName:"Lilith",surname:"Muedi",slug:"khathutshelo-muedi",fullName:"Khathutshelo Muedi"}]}],onlineFirstChaptersFilter:{topicId:"14",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"81825",title:"Quantification of Heavy Metal Levels in Sediments of the “Palizada” River in a Protected Natural Area of Southeastern Mexico",slug:"quantification-of-heavy-metal-levels-in-sediments-of-the-palizada-river-in-a-protected-natural-area-",totalDownloads:1,totalDimensionsCites:null,doi:"10.5772/intechopen.104657",abstract:"This chapter shows the results of the determination of the levels of Copper (Cu), Iron (Fe), Magnesium (Mg), Manganese (Mn), and Cadmium (Cd) in sediments of the “Palizada River”; evaluated by atomic absorption. The results show high levels of Fe, Mg, and Mn concerning previous studies and are directly related to agricultural and livestock activities in the area. The metal-metal correlation analysis show significant values, suggesting that the generation source is the same. Some of the pollutants produced by industrial or population centers; end up in natural water bodies; by different physical processes, such as precipitation, complex formation, and others. These contaminants can bioaccumulate in aquatic organisms and reach humans through the food chain. Certain heavy metals such as cadmium (Cd) produced by human activities have been found in the oceans and the tissues of different organisms; which constitutes a risk for consumption; Cd is classified as an element that predisposes to the presence of Cancer. Therefore, the study of sediments is fundamental for determining the degree of contamination of an ecosystem.",book:{id:"11120",title:"Environmental Impact and Remediation of Heavy Metals",coverURL:"https://cdn.intechopen.com/books/images_new/11120.jpg"},signatures:"Carlos Montalvo, Claudia A. Aguilar, Yunuen Canedo, Alejandro Ruiz, Brenda Zermeño, Ruby S. Gines and Rosa M. Cerón"},{id:"81461",title:"Fiber Inclusions-Based Epoxy Composites and Their Applications",slug:"fiber-inclusions-based-epoxy-composites-and-their-applications",totalDownloads:3,totalDimensionsCites:0,doi:"10.5772/intechopen.104118",abstract:"Because of their low cost, lightweight, easy production methods, and design flexibility, polymer-based composites are widely employed in a wide range of applications. Because of its high specific strength, superior mechanical characteristics, super adhesiveness, heat and solvent resistance, and so on, epoxy polymer or polyepoxide represent a significant majority of matrix composites. As a result, fiber fillers-reinforced epoxy resin composites have been investigated for a variety of applications, including high-tech in the ballistic, aircraft, automobile, construction, and sports sectors. In this chapter, the manufacturing procedures of fiber-reinforced epoxy composites have been described. Different categories of fiber are used as fillers in an epoxy matrix and their morphology is discussed as a function of the obtained properties.",book:{id:"11123",title:"Epoxy-Based Composites",coverURL:"https://cdn.intechopen.com/books/images_new/11123.jpg"},signatures:"Nassima Radouane and Abdelkrim Maaroufi"},{id:"81727",title:"Nanoparticle Based Collagen Biomaterials for Wound Healing",slug:"nanoparticle-based-collagen-biomaterials-for-wound-healing",totalDownloads:4,totalDimensionsCites:0,doi:"10.5772/intechopen.104851",abstract:"Wounds and infections are extremely common cases that are dealt with in the medical field. Their effective and timely treatment ensures the overall well-being of patients in general. Current treatments include the use of collagen scaffolds and other biomaterials for tissue regeneration. Although the use of collagenous biomaterials has been tested, the incorporation of nanoparticles into these collagenous biomaterials is a fairly new field, whose possibilities are yet to be explored and discovered. The current chapter explores the applications of the amalgamation of collagenous biomaterials with nanoparticles, which themselves are known to be effective in the treatment and prevention of infections.",book:{id:"10945",title:"Collagen Biomaterial",coverURL:"https://cdn.intechopen.com/books/images_new/10945.jpg"},signatures:"Kausalya Neelavara Makkithaya, Sharmila Nadumane, Guan-Yu Zhuo, Sanjiban Chakrabarty and Nirmal Mazumder"},{id:"81726",title:"Design and Fabrication of Microencapsulated Phase Change Materials for Energy/Thermal Energy Storage and Other Versatile Applications",slug:"design-and-fabrication-of-microencapsulated-phase-change-materials-for-energy-thermal-energy-storage",totalDownloads:3,totalDimensionsCites:0,doi:"10.5772/intechopen.102806",abstract:"Microencapsulated phase change materials have been considered as potential candidates to overcome the global energy shortage, as these materials can provide a viable method for storing thermal energy and offering consistent energy management by controllable heat release in desirable environments. Microencapsulation technology offers a method for overcoming the trouble associated with the handling of solid–liquid phase change materials (PCMs) via encapsulating PCMs with thin or tiny shells which are known as ‘microcapsules’. Microcapsule shells not only keep PCMs isolated from the surrounding materials but also provide a stable structure and sufficient surface for PCMs to enhance heat transfer. Thus microencapsulation technology received remarkable attention from fundamental studies to industrial growth in recent years. In order to provide a reliable source of information on recent progress and development in microencapsulated PCMs, this chapter emphases on methods and techniques for the encapsulation of PCMs with a diversity of shell materials from traditional organic polymers to novel inorganic materials to pursue high encapsulation efficiency, excellent thermal energy-storage performance and long-term operation durability. The chapter also highlights the design of bi- and multi-functional PCM-based microcapsules by fabricating various functional shells in a multilayered structure to meet the growing demand for versatile applications.",book:{id:"11077",title:"Microencapsulation - Recent Advances, New Perspectives and Applications of Smart Microcapsules",coverURL:"https://cdn.intechopen.com/books/images_new/11077.jpg"},signatures:"Tahira Mahmood, Rahmat Ali and Abdul Naeem"},{id:"81709",title:"New-Age Al-Cu-Mn-Zr (ACMZ) Alloy for High Temperature-High Strength Applications: A Review",slug:"new-age-al-cu-mn-zr-acmz-alloy-for-high-temperature-high-strength-applications-a-review",totalDownloads:8,totalDimensionsCites:0,doi:"10.5772/intechopen.104533",abstract:"One of the prime challenges with age hardened Al-Cu alloys is the strength degradation at high temperatures (above ∼250°C) due to the coarsening of strengthening θ′ precipitates and associated metastable θ′ → stable θ phase transformation. A recent discovery suggests that micro-alloying with Manganese (Mn) and Zirconium (Zr) can synergistically restrict θ′ precipitate coarsening, thereby rendering an excellent high temperature stability for Al-Cu-Mn-Zr (ACMZ) alloys. The θ′ precipitates are stabilized primarily from the reduction of interfacial energy by preferential solute segregation (Mn & Zr) at θ′ precipitate/α-Al matrix interfaces. The Al-Cu-Mn-Zr alloys thereby exhibit excellent high temperature hardness and tensile properties (yield and ultimate tensile strength) in addition to superior fatigue life and creep resistance. This newly developed Al-Cu-Mn-Zr alloys also showed excellent hot tearing resistance compared to the conventional cast Al-Cu alloys so much so that it meets the industrial standards as well. These alloys also have promising manufacturing possibility by additive route. Overall, Al-Cu-Mn-Zr alloys offer great potential for the automotive industry because of their unprecedented high temperature performance which should enable engineers to build light weight passenger vehicles leading to a safer and greener environment.",book:{id:"10847",title:"Aluminium Alloys - Design and Development of Innovative Alloys, Manufacturing Processes and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10847.jpg"},signatures:"Samarendra Roy and Shibayan Roy"},{id:"81716",title:"Groove Shape Optimization on Dry Gas Seals",slug:"groove-shape-optimization-on-dry-gas-seals",totalDownloads:7,totalDimensionsCites:0,doi:"10.5772/intechopen.103088",abstract:"In this paper, a topological optimum design for the shape of a groove in a dry gas seal is described. Dry gas seals are widely used in high speed and high pressure rotating machinery such as gas turbines, compressors, and so on because of their high reliability compared to other types of seals. However, recent requirements for reducing emission with further control of leakage are in order. With this background, we propose applying topological optimization to the groove shape in a dry gas seal to reduce its leakage while keeping its stiffness for safe operation. First, the method of topological optimum design as applied to the groove of a dry gas seal is explained via numerical analysis. Next, results of the topological optimization are shown via categorizing an optimum shape map. Finally, the mechanism of reducing the gas leakage with an optimized seal is discussed based on the prediction of the flow field using a CFD analysis.",book:{id:"10848",title:"Tribology of Machine Elements – Fundamentals and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10848.jpg"},signatures:"Masayuki Ochiai and Yuki Sato"}],onlineFirstChaptersTotal:87},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:8,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:98,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:286,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:106,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:9,numberOfPublishedChapters:101,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:11,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"6",title:"Infectious Diseases",doi:"10.5772/intechopen.71852",issn:"2631-6188",scope:"This series will provide a comprehensive overview of recent research trends in various Infectious Diseases (as per the most recent Baltimore classification). Topics will include general overviews of infections, immunopathology, diagnosis, treatment, epidemiology, etiology, and current clinical recommendations for managing infectious diseases. Ongoing issues, recent advances, and future diagnostic approaches and therapeutic strategies will also be discussed. This book series will focus on various aspects and properties of infectious diseases whose deep understanding is essential for safeguarding the human race from losing resources and economies due to pathogens.",coverUrl:"https://cdn.intechopen.com/series/covers/6.jpg",latestPublicationDate:"May 17th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:13,editor:{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",biography:"Dr. Rodriguez-Morales is an expert in tropical and emerging diseases, particularly zoonotic and vector-borne diseases (especially arboviral diseases). He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},editorTwo:null,editorThree:null},subseries:{paginationCount:6,paginationItems:[{id:"22",title:"Applied Intelligence",coverUrl:"https://cdn.intechopen.com/series_topics/covers/22.jpg",isOpenForSubmission:!0,editor:{id:"27170",title:"Prof.",name:"Carlos",middleName:"M.",surname:"Travieso-Gonzalez",slug:"carlos-travieso-gonzalez",fullName:"Carlos Travieso-Gonzalez",profilePictureURL:"https://mts.intechopen.com/storage/users/27170/images/system/27170.jpeg",biography:"Carlos M. Travieso-González received his MSc degree in Telecommunication Engineering at Polytechnic University of Catalonia (UPC), Spain in 1997, and his Ph.D. degree in 2002 at the University of Las Palmas de Gran Canaria (ULPGC-Spain). He is a full professor of signal processing and pattern recognition and is head of the Signals and Communications Department at ULPGC, teaching from 2001 on subjects on signal processing and learning theory. His research lines are biometrics, biomedical signals and images, data mining, classification system, signal and image processing, machine learning, and environmental intelligence. He has researched in 52 international and Spanish research projects, some of them as head researcher. He is co-author of 4 books, co-editor of 27 proceedings books, guest editor for 8 JCR-ISI international journals, and up to 24 book chapters. He has over 450 papers published in international journals and conferences (81 of them indexed on JCR – ISI - Web of Science). He has published seven patents in the Spanish Patent and Trademark Office. He has been a supervisor on 8 Ph.D. theses (11 more are under supervision), and 130 master theses. He is the founder of The IEEE IWOBI conference series and the president of its Steering Committee, as well as the founder of both the InnoEducaTIC and APPIS conference series. He is an evaluator of project proposals for the European Union (H2020), Medical Research Council (MRC, UK), Spanish Government (ANECA, Spain), Research National Agency (ANR, France), DAAD (Germany), Argentinian Government, and the Colombian Institutions. He has been a reviewer in different indexed international journals (<70) and conferences (<250) since 2001. He has been a member of the IASTED Technical Committee on Image Processing from 2007 and a member of the IASTED Technical Committee on Artificial Intelligence and Expert Systems from 2011. \n\nHe has held the general chair position for the following: ACM-APPIS (2020, 2021), IEEE-IWOBI (2019, 2020 and 2020), A PPIS (2018, 2019), IEEE-IWOBI (2014, 2015, 2017, 2018), InnoEducaTIC (2014, 2017), IEEE-INES (2013), NoLISP (2011), JRBP (2012), and IEEE-ICCST (2005)\n\nHe is an associate editor of the Computational Intelligence and Neuroscience Journal (Hindawi – Q2 JCR-ISI). He was vice dean from 2004 to 2010 in the Higher Technical School of Telecommunication Engineers at ULPGC and the vice dean of Graduate and Postgraduate Studies from March 2013 to November 2017. He won the “Catedra Telefonica” Awards in Modality of Knowledge Transfer, 2017, 2018, and 2019 editions, and awards in Modality of COVID Research in 2020.\n\nPublic References:\nResearcher ID http://www.researcherid.com/rid/N-5967-2014\nORCID https://orcid.org/0000-0002-4621-2768 \nScopus Author ID https://www.scopus.com/authid/detail.uri?authorId=6602376272\nScholar Google https://scholar.google.es/citations?user=G1ks9nIAAAAJ&hl=en \nResearchGate https://www.researchgate.net/profile/Carlos_Travieso",institutionString:null,institution:{name:"University of Las Palmas de Gran Canaria",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"23",title:"Computational Neuroscience",coverUrl:"https://cdn.intechopen.com/series_topics/covers/23.jpg",isOpenForSubmission:!0,editor:{id:"14004",title:"Dr.",name:"Magnus",middleName:null,surname:"Johnsson",slug:"magnus-johnsson",fullName:"Magnus Johnsson",profilePictureURL:"https://mts.intechopen.com/storage/users/14004/images/system/14004.png",biography:"Dr Magnus Johnsson is a cross-disciplinary scientist, lecturer, scientific editor and AI/machine learning consultant from Sweden. \n\nHe is currently at Malmö University in Sweden, but also held positions at Lund University in Sweden and at Moscow Engineering Physics Institute. \nHe holds editorial positions at several international scientific journals and has served as a scientific editor for books and special journal issues. \nHis research interests are wide and include, but are not limited to, autonomous systems, computer modeling, artificial neural networks, artificial intelligence, cognitive neuroscience, cognitive robotics, cognitive architectures, cognitive aids and the philosophy of mind. \n\nDr. Johnsson has experience from working in the industry and he has a keen interest in the application of neural networks and artificial intelligence to fields like industry, finance, and medicine. \n\nWeb page: www.magnusjohnsson.se",institutionString:null,institution:{name:"Malmö University",institutionURL:null,country:{name:"Sweden"}}},editorTwo:null,editorThree:null},{id:"24",title:"Computer Vision",coverUrl:"https://cdn.intechopen.com/series_topics/covers/24.jpg",isOpenForSubmission:!0,editor:{id:"294154",title:"Prof.",name:"George",middleName:null,surname:"Papakostas",slug:"george-papakostas",fullName:"George Papakostas",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002hYaGbQAK/Profile_Picture_1624519712088",biography:"George A. Papakostas has received a diploma in Electrical and Computer Engineering in 1999 and the M.Sc. and Ph.D. degrees in Electrical and Computer Engineering in 2002 and 2007, respectively, from the Democritus University of Thrace (DUTH), Greece. Dr. Papakostas serves as a Tenured Full Professor at the Department of Computer Science, International Hellenic University, Greece. Dr. Papakostas has 10 years of experience in large-scale systems design as a senior software engineer and technical manager, and 20 years of research experience in the field of Artificial Intelligence. Currently, he is the Head of the “Visual Computing” division of HUman-MAchines INteraction Laboratory (HUMAIN-Lab) and the Director of the MPhil program “Advanced Technologies in Informatics and Computers” hosted by the Department of Computer Science, International Hellenic University. He has (co)authored more than 150 publications in indexed journals, international conferences and book chapters, 1 book (in Greek), 3 edited books, and 5 journal special issues. His publications have more than 2100 citations with h-index 27 (GoogleScholar). His research interests include computer/machine vision, machine learning, pattern recognition, computational intelligence. \nDr. Papakostas served as a reviewer in numerous journals, as a program\ncommittee member in international conferences and he is a member of the IAENG, MIR Labs, EUCogIII, INSTICC and the Technical Chamber of Greece (TEE).",institutionString:null,institution:{name:"International Hellenic University",institutionURL:null,country:{name:"Greece"}}},editorTwo:null,editorThree:null},{id:"25",title:"Evolutionary Computation",coverUrl:"https://cdn.intechopen.com/series_topics/covers/25.jpg",isOpenForSubmission:!0,editor:{id:"136112",title:"Dr.",name:"Sebastian",middleName:null,surname:"Ventura Soto",slug:"sebastian-ventura-soto",fullName:"Sebastian Ventura Soto",profilePictureURL:"https://mts.intechopen.com/storage/users/136112/images/system/136112.png",biography:"Sebastian Ventura is a Spanish researcher, a full professor with the Department of Computer Science and Numerical Analysis, University of Córdoba. Dr Ventura also holds the positions of Affiliated Professor at Virginia Commonwealth University (Richmond, USA) and Distinguished Adjunct Professor at King Abdulaziz University (Jeddah, Saudi Arabia). Additionally, he is deputy director of the Andalusian Research Institute in Data Science and Computational Intelligence (DaSCI) and heads the Knowledge Discovery and Intelligent Systems Research Laboratory. He has published more than ten books and over 300 articles in journals and scientific conferences. Currently, his work has received over 18,000 citations according to Google Scholar, including more than 2200 citations in 2020. In the last five years, he has published more than 60 papers in international journals indexed in the JCR (around 70% of them belonging to first quartile journals) and he has edited some Springer books “Supervised Descriptive Pattern Mining” (2018), “Multiple Instance Learning - Foundations and Algorithms” (2016), and “Pattern Mining with Evolutionary Algorithms” (2016). He has also been involved in more than 20 research projects supported by the Spanish and Andalusian governments and the European Union. He currently belongs to the editorial board of PeerJ Computer Science, Information Fusion and Engineering Applications of Artificial Intelligence journals, being also associate editor of Applied Computational Intelligence and Soft Computing and IEEE Transactions on Cybernetics. Finally, he is editor-in-chief of Progress in Artificial Intelligence. He is a Senior Member of the IEEE Computer, the IEEE Computational Intelligence, and the IEEE Systems, Man, and Cybernetics Societies, and the Association of Computing Machinery (ACM). Finally, his main research interests include data science, computational intelligence, and their applications.",institutionString:null,institution:{name:"University of Córdoba",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"26",title:"Machine Learning and Data Mining",coverUrl:"https://cdn.intechopen.com/series_topics/covers/26.jpg",isOpenForSubmission:!0,editor:{id:"24555",title:"Dr.",name:"Marco Antonio",middleName:null,surname:"Aceves Fernandez",slug:"marco-antonio-aceves-fernandez",fullName:"Marco Antonio Aceves Fernandez",profilePictureURL:"https://mts.intechopen.com/storage/users/24555/images/system/24555.jpg",biography:"Dr. Marco Antonio Aceves Fernandez obtained his B.Sc. (Eng.) in Telematics from the Universidad de Colima, Mexico. He obtained both his M.Sc. and Ph.D. from the University of Liverpool, England, in the field of Intelligent Systems. He is a full professor at the Universidad Autonoma de Queretaro, Mexico, and a member of the National System of Researchers (SNI) since 2009. Dr. Aceves Fernandez has published more than 80 research papers as well as a number of book chapters and congress papers. He has contributed in more than 20 funded research projects, both academic and industrial, in the area of artificial intelligence, ranging from environmental, biomedical, automotive, aviation, consumer, and robotics to other applications. He is also a honorary president at the National Association of Embedded Systems (AMESE), a senior member of the IEEE, and a board member of many institutions. His research interests include intelligent and embedded systems.",institutionString:"Universidad Autonoma de Queretaro",institution:{name:"Autonomous University of Queretaro",institutionURL:null,country:{name:"Mexico"}}},editorTwo:null,editorThree:null},{id:"27",title:"Multi-Agent Systems",coverUrl:"https://cdn.intechopen.com/series_topics/covers/27.jpg",isOpenForSubmission:!0,editor:{id:"148497",title:"Dr.",name:"Mehmet",middleName:"Emin",surname:"Aydin",slug:"mehmet-aydin",fullName:"Mehmet Aydin",profilePictureURL:"https://mts.intechopen.com/storage/users/148497/images/system/148497.jpg",biography:"Dr. Mehmet Emin Aydin is a Senior Lecturer with the Department of Computer Science and Creative Technology, the University of the West of England, Bristol, UK. His research interests include swarm intelligence, parallel and distributed metaheuristics, machine learning, intelligent agents and multi-agent systems, resource planning, scheduling and optimization, combinatorial optimization. Dr. Aydin is currently a Fellow of Higher Education Academy, UK, a member of EPSRC College, a senior member of IEEE and a senior member of ACM. In addition to being a member of advisory committees of many international conferences, he is an Editorial Board Member of various peer-reviewed international journals. He has served as guest editor for a number of special issues of peer-reviewed international journals.",institutionString:null,institution:{name:"University of the West of England",institutionURL:null,country:{name:"United Kingdom"}}},editorTwo:null,editorThree:null}]},overviewPageOFChapters:{paginationCount:26,paginationItems:[{id:"81791",title:"Self-Supervised Contrastive Representation Learning in Computer Vision",doi:"10.5772/intechopen.104785",signatures:"Yalin Bastanlar and Semih Orhan",slug:"self-supervised-contrastive-representation-learning-in-computer-vision",totalDownloads:3,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Pattern Recognition - New Insights",coverURL:"https://cdn.intechopen.com/books/images_new/11442.jpg",subseries:{id:"26",title:"Machine Learning and Data Mining"}}},{id:"79345",title:"Application of Jump Diffusion Models in Insurance Claim Estimation",doi:"10.5772/intechopen.99853",signatures:"Leonard Mushunje, Chiedza Elvina Mashiri, Edina Chandiwana and Maxwell Mashasha",slug:"application-of-jump-diffusion-models-in-insurance-claim-estimation-1",totalDownloads:2,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Data Clustering",coverURL:"https://cdn.intechopen.com/books/images_new/10820.jpg",subseries:{id:"26",title:"Machine Learning and Data Mining"}}},{id:"81557",title:"Object Tracking Using Adapted Optical Flow",doi:"10.5772/intechopen.102863",signatures:"Ronaldo Ferreira, Joaquim José de Castro Ferreira and António José Ribeiro Neves",slug:"object-tracking-using-adapted-optical-flow",totalDownloads:10,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Information Extraction and Object Tracking in Digital Video",coverURL:"https://cdn.intechopen.com/books/images_new/10652.jpg",subseries:{id:"24",title:"Computer Vision"}}},{id:"81558",title:"Thresholding Image Techniques for Plant Segmentation",doi:"10.5772/intechopen.104587",signatures:"Miguel Ángel Castillo-Martínez, Francisco Javier Gallegos-Funes, Blanca E. Carvajal-Gámez, Guillermo Urriolagoitia-Sosa and Alberto J. Rosales-Silva",slug:"thresholding-image-techniques-for-plant-segmentation",totalDownloads:13,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Information Extraction and Object Tracking in Digital Video",coverURL:"https://cdn.intechopen.com/books/images_new/10652.jpg",subseries:{id:"24",title:"Computer Vision"}}}]},overviewPagePublishedBooks:{paginationCount:8,paginationItems:[{type:"book",id:"7723",title:"Artificial Intelligence",subtitle:"Applications in Medicine and Biology",coverURL:"https://cdn.intechopen.com/books/images_new/7723.jpg",slug:"artificial-intelligence-applications-in-medicine-and-biology",publishedDate:"July 31st 2019",editedByType:"Edited by",bookSignature:"Marco Antonio Aceves-Fernandez",hash:"a3852659e727f95c98c740ed98146011",volumeInSeries:1,fullTitle:"Artificial Intelligence - Applications in Medicine and Biology",editors:[{id:"24555",title:"Dr.",name:"Marco Antonio",middleName:null,surname:"Aceves Fernandez",slug:"marco-antonio-aceves-fernandez",fullName:"Marco Antonio Aceves Fernandez",profilePictureURL:"https://mts.intechopen.com/storage/users/24555/images/system/24555.jpg",biography:"Dr. Marco Antonio Aceves Fernandez obtained his B.Sc. (Eng.) in Telematics from the Universidad de Colima, Mexico. He obtained both his M.Sc. and Ph.D. from the University of Liverpool, England, in the field of Intelligent Systems. He is a full professor at the Universidad Autonoma de Queretaro, Mexico, and a member of the National System of Researchers (SNI) since 2009. Dr. Aceves Fernandez has published more than 80 research papers as well as a number of book chapters and congress papers. He has contributed in more than 20 funded research projects, both academic and industrial, in the area of artificial intelligence, ranging from environmental, biomedical, automotive, aviation, consumer, and robotics to other applications. He is also a honorary president at the National Association of Embedded Systems (AMESE), a senior member of the IEEE, and a board member of many institutions. His research interests include intelligent and embedded systems.",institutionString:"Universidad Autonoma de Queretaro",institution:{name:"Autonomous University of Queretaro",institutionURL:null,country:{name:"Mexico"}}}]},{type:"book",id:"7726",title:"Swarm Intelligence",subtitle:"Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/7726.jpg",slug:"swarm-intelligence-recent-advances-new-perspectives-and-applications",publishedDate:"December 4th 2019",editedByType:"Edited by",bookSignature:"Javier Del Ser, Esther Villar and Eneko Osaba",hash:"e7ea7e74ce7a7a8e5359629e07c68d31",volumeInSeries:2,fullTitle:"Swarm Intelligence - Recent Advances, New Perspectives and Applications",editors:[{id:"49813",title:"Dr.",name:"Javier",middleName:null,surname:"Del Ser",slug:"javier-del-ser",fullName:"Javier Del Ser",profilePictureURL:"https://mts.intechopen.com/storage/users/49813/images/system/49813.png",biography:"Prof. Dr. Javier Del Ser received his first PhD in Telecommunication Engineering (Cum Laude) from the University of Navarra, Spain, in 2006, and a second PhD in Computational Intelligence (Summa Cum Laude) from the University of Alcala, Spain, in 2013. He is currently a principal researcher in data analytics and optimisation at TECNALIA (Spain), a visiting fellow at the Basque Center for Applied Mathematics (BCAM) and a part-time lecturer at the University of the Basque Country (UPV/EHU). His research interests gravitate on the use of descriptive, prescriptive and predictive algorithms for data mining and optimization in a diverse range of application fields such as Energy, Transport, Telecommunications, Health and Industry, among others. In these fields he has published more than 240 articles, co-supervised 8 Ph.D. theses, edited 6 books, coauthored 7 patents and participated/led more than 40 research projects. He is a Senior Member of the IEEE, and a recipient of the Biscay Talent prize for his academic career.",institutionString:"Tecnalia Research & Innovation",institution:null}]},{type:"book",id:"7656",title:"Fuzzy Logic",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7656.jpg",slug:"fuzzy-logic",publishedDate:"February 5th 2020",editedByType:"Edited by",bookSignature:"Constantin Volosencu",hash:"54f092d4ffe0abf5e4172a80025019bc",volumeInSeries:3,fullTitle:"Fuzzy Logic",editors:[{id:"1063",title:"Prof.",name:"Constantin",middleName:null,surname:"Volosencu",slug:"constantin-volosencu",fullName:"Constantin Volosencu",profilePictureURL:"https://mts.intechopen.com/storage/users/1063/images/system/1063.png",biography:"Prof. Dr. Constantin Voloşencu graduated as an engineer from\nPolitehnica University of Timișoara, Romania, where he also\nobtained a doctorate degree. He is currently a full professor in\nthe Department of Automation and Applied Informatics at the\nsame university. Dr. Voloşencu is the author of ten books, seven\nbook chapters, and more than 160 papers published in journals\nand conference proceedings. He has also edited twelve books and\nhas twenty-seven patents to his name. He is a manager of research grants, editor in\nchief and member of international journal editorial boards, a former plenary speaker, a member of scientific committees, and chair at international conferences. His\nresearch is in the fields of control systems, control of electric drives, fuzzy control\nsystems, neural network applications, fault detection and diagnosis, sensor network\napplications, monitoring of distributed parameter systems, and power ultrasound\napplications. He has developed automation equipment for machine tools, spooling\nmachines, high-power ultrasound processes, and more.",institutionString:"Polytechnic University of Timişoara",institution:{name:"Polytechnic University of Timişoara",institutionURL:null,country:{name:"Romania"}}}]},{type:"book",id:"9963",title:"Advances and Applications in Deep Learning",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9963.jpg",slug:"advances-and-applications-in-deep-learning",publishedDate:"December 9th 2020",editedByType:"Edited by",bookSignature:"Marco Antonio Aceves-Fernandez",hash:"0d51ba46f22e55cb89140f60d86a071e",volumeInSeries:4,fullTitle:"Advances and Applications in Deep Learning",editors:[{id:"24555",title:"Dr.",name:"Marco Antonio",middleName:null,surname:"Aceves Fernandez",slug:"marco-antonio-aceves-fernandez",fullName:"Marco Antonio Aceves Fernandez",profilePictureURL:"https://mts.intechopen.com/storage/users/24555/images/system/24555.jpg",biography:"Dr. Marco Antonio Aceves Fernandez obtained his B.Sc. (Eng.) in Telematics from the Universidad de Colima, Mexico. He obtained both his M.Sc. and Ph.D. from the University of Liverpool, England, in the field of Intelligent Systems. He is a full professor at the Universidad Autonoma de Queretaro, Mexico, and a member of the National System of Researchers (SNI) since 2009. Dr. Aceves Fernandez has published more than 80 research papers as well as a number of book chapters and congress papers. He has contributed in more than 20 funded research projects, both academic and industrial, in the area of artificial intelligence, ranging from environmental, biomedical, automotive, aviation, consumer, and robotics to other applications. He is also a honorary president at the National Association of Embedded Systems (AMESE), a senior member of the IEEE, and a board member of many institutions. His research interests include intelligent and embedded systems.",institutionString:"Universidad Autonoma de Queretaro",institution:{name:"Autonomous University of Queretaro",institutionURL:null,country:{name:"Mexico"}}}]}]},openForSubmissionBooks:{paginationCount:2,paginationItems:[{id:"11603",title:"People Management - Highlighting Futures",coverURL:"https://cdn.intechopen.com/books/images_new/11603.jpg",hash:"982c56a5fb4684d966f8f5e76b2638f5",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"March 22nd 2022",isOpenForSubmission:!0,editors:[{id:"450553",title:"Dr.",name:"Diana",surname:"Dias",slug:"diana-dias",fullName:"Diana Dias"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11601",title:"Econometrics - Recent Advances and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/11601.jpg",hash:"bc8ab49e2cf436c217a49ca8c12a22eb",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"May 13th 2022",isOpenForSubmission:!0,editors:[{id:"452331",title:"Dr.",name:"Brian",surname:"Sloboda",slug:"brian-sloboda",fullName:"Brian Sloboda"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},onlineFirstChapters:{paginationCount:25,paginationItems:[{id:"81793",title:"Canine parvovirus-2: An Emerging Threat to Young Pets",doi:"10.5772/intechopen.104846",signatures:"Mithilesh Singh, Rajendran Manikandan, Ujjwal Kumar De, Vishal Chander, Babul Rudra Paul, Saravanan Ramakrishnan and Darshini Maramreddy",slug:"canine-parvovirus-2-an-emerging-threat-to-young-pets",totalDownloads:2,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Recent Advances in Canine Medicine",coverURL:"https://cdn.intechopen.com/books/images_new/11580.jpg",subseries:{id:"19",title:"Animal Science"}}},{id:"81271",title:"The Diversity of Parvovirus Telomeres",doi:"10.5772/intechopen.102684",signatures:"Marianne Laugel, Emilie Lecomte, Eduard Ayuso, Oumeya Adjali, Mathieu Mével and Magalie Penaud-Budloo",slug:"the-diversity-of-parvovirus-telomeres",totalDownloads:23,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Recent Advances in Canine Medicine",coverURL:"https://cdn.intechopen.com/books/images_new/11580.jpg",subseries:{id:"19",title:"Animal Science"}}},{id:"80187",title:"Potential Utilization of Insect Meal as Livestock Feed",doi:"10.5772/intechopen.101766",signatures:"Sipho Moyo and Busani Moyo",slug:"potential-utilization-of-insect-meal-as-livestock-feed",totalDownloads:101,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Animal Feed Science and Nutrition - Production, Health and Environment",coverURL:"https://cdn.intechopen.com/books/images_new/10830.jpg",subseries:{id:"20",title:"Animal Nutrition"}}},{id:"79909",title:"Cryopreservation Methods and Frontiers in the Art of Freezing Life in Animal Models",doi:"10.5772/intechopen.101750",signatures:"Feda S. Aljaser",slug:"cryopreservation-methods-and-frontiers-in-the-art-of-freezing-life-in-animal-models",totalDownloads:160,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Animal Reproduction",coverURL:"https://cdn.intechopen.com/books/images_new/10664.jpg",subseries:{id:"28",title:"Animal Reproductive Biology and Technology"}}},{id:"79866",title:"Ruminal Microbiome Manipulation to Improve Fermentation Efficiency in Ruminants",doi:"10.5772/intechopen.101582",signatures:"Yosra Ahmed Soltan and Amlan Kumar Patra",slug:"ruminal-microbiome-manipulation-to-improve-fermentation-efficiency-in-ruminants",totalDownloads:216,totalCrossrefCites:0,totalDimensionsCites:1,authors:null,book:{title:"Animal Feed Science and Nutrition - Production, Health and Environment",coverURL:"https://cdn.intechopen.com/books/images_new/10830.jpg",subseries:{id:"20",title:"Animal Nutrition"}}},{id:"79782",title:"Avian Reproduction",doi:"10.5772/intechopen.101185",signatures:"Kingsley Omogiade Idahor",slug:"avian-reproduction",totalDownloads:149,totalCrossrefCites:0,totalDimensionsCites:0,authors:[{name:"Kingsley O.",surname:"Idahor"}],book:{title:"Animal Reproduction",coverURL:"https://cdn.intechopen.com/books/images_new/10664.jpg",subseries:{id:"28",title:"Animal Reproductive Biology and Technology"}}},{id:"78802",title:"Intraovarian Gestation in Viviparous Teleosts: Unique Type of Gestation among Vertebrates",doi:"10.5772/intechopen.100267",signatures:"Mari-Carmen Uribe, Gabino De la Rosa-Cruz, Adriana García-Alarcón and Juan Carlos Campuzano-Caballero",slug:"intraovarian-gestation-in-viviparous-teleosts-unique-type-of-gestation-among-vertebrates",totalDownloads:183,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Animal Reproduction",coverURL:"https://cdn.intechopen.com/books/images_new/10664.jpg",subseries:{id:"28",title:"Animal Reproductive Biology and Technology"}}},{id:"79209",title:"Virtual Physiology: A Tool for the 21st Century",doi:"10.5772/intechopen.99671",signatures:"Carmen Nóbrega, Maria Aires Pereira, Catarina Coelho, Isabel Brás, Ana Cristina Mega, Carla Santos, Fernando Esteves, Rita Cruz, Ana I. Faustino-Rocha, Paula A. Oliveira, João Mesquita and Helena Vala",slug:"virtual-physiology-a-tool-for-the-21st-century",totalDownloads:136,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Updates on Veterinary Anatomy and Physiology",coverURL:"https://cdn.intechopen.com/books/images_new/10665.jpg",subseries:{id:"19",title:"Animal Science"}}},{id:"78849",title:"Application of Vermicompost Fertilizer in Aquaculture Nutrition: Review",doi:"10.5772/intechopen.100326",signatures:"Sonnia Nzilani Musyoka and Rita Nairuti",slug:"application-of-vermicompost-fertilizer-in-aquaculture-nutrition-review",totalDownloads:67,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Animal Nutrition - Annual Volume 2022",coverURL:"https://cdn.intechopen.com/books/images_new/11416.jpg",subseries:{id:"20",title:"Animal Nutrition"}}},{id:"78998",title:"Effect of Various Feed Additives on the Methane Emissions from Beef Cattle Based on an Ammoniated Palm Frond Feeds",doi:"10.5772/intechopen.100142",signatures:"Mardiati Zain, Rusmana Wijaya Setia Ningrat, Heni Suryani and Novirman Jamarun",slug:"effect-of-various-feed-additives-on-the-methane-emissions-from-beef-cattle-based-on-an-ammoniated-pa",totalDownloads:143,totalCrossrefCites:0,totalDimensionsCites:1,authors:null,book:{title:"Animal Feed Science and Nutrition - Production, Health and Environment",coverURL:"https://cdn.intechopen.com/books/images_new/10830.jpg",subseries:{id:"20",title:"Animal Nutrition"}}}]},subseriesFiltersForOFChapters:[{caption:"Animal Nutrition",value:20,count:7,group:"subseries"},{caption:"Animal Reproductive Biology and Technology",value:28,count:7,group:"subseries"},{caption:"Animal Science",value:19,count:11,group:"subseries"}],publishedBooks:{paginationCount:27,paginationItems:[{type:"book",id:"10803",title:"Reactive Oxygen Species",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/10803.jpg",slug:"reactive-oxygen-species",publishedDate:"April 28th 2022",editedByType:"Edited by",bookSignature:"Rizwan Ahmad",hash:"176adcf090fdd1f93cb8ce3146e79ca1",volumeInSeries:28,fullTitle:"Reactive Oxygen Species",editors:[{id:"40482",title:null,name:"Rizwan",middleName:null,surname:"Ahmad",slug:"rizwan-ahmad",fullName:"Rizwan Ahmad",profilePictureURL:"https://mts.intechopen.com/storage/users/40482/images/system/40482.jpeg",institutionString:"Imam Abdulrahman Bin Faisal University",institution:{name:"Imam Abdulrahman Bin Faisal University",institutionURL:null,country:{name:"Saudi Arabia"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9008",title:"Vitamin K",subtitle:"Recent Topics on the Biology and Chemistry",coverURL:"https://cdn.intechopen.com/books/images_new/9008.jpg",slug:"vitamin-k-recent-topics-on-the-biology-and-chemistry",publishedDate:"March 23rd 2022",editedByType:"Edited by",bookSignature:"Hiroyuki Kagechika and Hitoshi Shirakawa",hash:"8b43add5389ba85743e0a9491e4b9943",volumeInSeries:27,fullTitle:"Vitamin K - Recent Topics on the Biology and Chemistry",editors:[{id:"180528",title:"Dr.",name:"Hiroyuki",middleName:null,surname:"Kagechika",slug:"hiroyuki-kagechika",fullName:"Hiroyuki Kagechika",profilePictureURL:"https://mts.intechopen.com/storage/users/180528/images/system/180528.jpg",institutionString:"Tokyo Medical and Dental University",institution:{name:"Tokyo Medical and Dental University",institutionURL:null,country:{name:"Japan"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"10799",title:"Phenolic Compounds",subtitle:"Chemistry, Synthesis, Diversity, Non-Conventional Industrial, Pharmaceutical and Therapeutic Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10799.jpg",slug:"phenolic-compounds-chemistry-synthesis-diversity-non-conventional-industrial-pharmaceutical-and-therapeutic-applications",publishedDate:"February 23rd 2022",editedByType:"Edited by",bookSignature:"Farid A. Badria",hash:"339199f254d2987ef3167eef74fb8a38",volumeInSeries:26,fullTitle:"Phenolic Compounds - Chemistry, Synthesis, Diversity, Non-Conventional Industrial, Pharmaceutical and Therapeutic Applications",editors:[{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria",profilePictureURL:"https://mts.intechopen.com/storage/users/41865/images/system/41865.jpg",institutionString:"Mansoura University",institution:{name:"Mansoura University",institutionURL:null,country:{name:"Egypt"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9659",title:"Fibroblasts",subtitle:"Advances in Inflammation, Autoimmunity and Cancer",coverURL:"https://cdn.intechopen.com/books/images_new/9659.jpg",slug:"fibroblasts-advances-in-inflammation-autoimmunity-and-cancer",publishedDate:"December 22nd 2021",editedByType:"Edited by",bookSignature:"Mojca Frank Bertoncelj and Katja Lakota",hash:"926fa6446f6befbd363fc74971a56de2",volumeInSeries:25,fullTitle:"Fibroblasts - Advances in Inflammation, Autoimmunity and Cancer",editors:[{id:"328755",title:"Ph.D.",name:"Mojca",middleName:null,surname:"Frank Bertoncelj",slug:"mojca-frank-bertoncelj",fullName:"Mojca Frank Bertoncelj",profilePictureURL:"https://mts.intechopen.com/storage/users/328755/images/system/328755.jpg",institutionString:"BioMed X Institute",institution:{name:"University Hospital of Zurich",institutionURL:null,country:{name:"Switzerland"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8977",title:"Protein Kinases",subtitle:"Promising Targets for Anticancer Drug Research",coverURL:"https://cdn.intechopen.com/books/images_new/8977.jpg",slug:"protein-kinases-promising-targets-for-anticancer-drug-research",publishedDate:"December 8th 2021",editedByType:"Edited by",bookSignature:"Rajesh Kumar Singh",hash:"6d200cc031706a565b554fdb1c478901",volumeInSeries:24,fullTitle:"Protein Kinases - Promising Targets for Anticancer Drug Research",editors:[{id:"329385",title:"Dr.",name:"Rajesh K.",middleName:"Kumar",surname:"Singh",slug:"rajesh-k.-singh",fullName:"Rajesh K. Singh",profilePictureURL:"https://mts.intechopen.com/storage/users/329385/images/system/329385.png",institutionString:"Punjab Technical University",institution:{name:"Punjab Technical University",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8018",title:"Extracellular Matrix",subtitle:"Developments and Therapeutics",coverURL:"https://cdn.intechopen.com/books/images_new/8018.jpg",slug:"extracellular-matrix-developments-and-therapeutics",publishedDate:"October 27th 2021",editedByType:"Edited by",bookSignature:"Rama Sashank Madhurapantula, Joseph Orgel P.R.O. and Zvi Loewy",hash:"c85e82851e80b40282ff9be99ddf2046",volumeInSeries:23,fullTitle:"Extracellular Matrix - Developments and Therapeutics",editors:[{id:"212416",title:"Dr.",name:"Rama Sashank",middleName:null,surname:"Madhurapantula",slug:"rama-sashank-madhurapantula",fullName:"Rama Sashank Madhurapantula",profilePictureURL:"https://mts.intechopen.com/storage/users/212416/images/system/212416.jpg",institutionString:"Illinois Institute of Technology",institution:{name:"Illinois Institute of Technology",institutionURL:null,country:{name:"United States of America"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9759",title:"Vitamin E in Health and Disease",subtitle:"Interactions, Diseases and Health Aspects",coverURL:"https://cdn.intechopen.com/books/images_new/9759.jpg",slug:"vitamin-e-in-health-and-disease-interactions-diseases-and-health-aspects",publishedDate:"October 6th 2021",editedByType:"Edited by",bookSignature:"Pınar Erkekoglu and Júlia Scherer Santos",hash:"6c3ddcc13626110de289b57f2516ac8f",volumeInSeries:22,fullTitle:"Vitamin E in Health and Disease - Interactions, Diseases and Health Aspects",editors:[{id:"109978",title:"Prof.",name:"Pınar",middleName:null,surname:"Erkekoğlu",slug:"pinar-erkekoglu",fullName:"Pınar Erkekoğlu",profilePictureURL:"https://mts.intechopen.com/storage/users/109978/images/system/109978.jpg",institutionString:"Hacettepe University",institution:{name:"Hacettepe University",institutionURL:null,country:{name:"Turkey"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9753",title:"Terpenes and Terpenoids",subtitle:"Recent Advances",coverURL:"https://cdn.intechopen.com/books/images_new/9753.jpg",slug:"terpenes-and-terpenoids-recent-advances",publishedDate:"July 28th 2021",editedByType:"Edited by",bookSignature:"Shagufta Perveen and Areej Mohammad Al-Taweel",hash:"575689df13c78bf0e6c1be40804cd010",volumeInSeries:21,fullTitle:"Terpenes and Terpenoids - Recent Advances",editors:[{id:"192992",title:"Prof.",name:"Shagufta",middleName:null,surname:"Perveen",slug:"shagufta-perveen",fullName:"Shagufta Perveen",profilePictureURL:"https://mts.intechopen.com/storage/users/192992/images/system/192992.png",institutionString:"King Saud University",institution:{name:"King Saud University",institutionURL:null,country:{name:"Saudi Arabia"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9403",title:"Human Microbiome",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9403.jpg",slug:"human-microbiome",publishedDate:"June 16th 2021",editedByType:"Edited by",bookSignature:"Natalia V. Beloborodova and Andrey V. Grechko",hash:"c31366ba82585ba3ac91d21eb1cf0a4d",volumeInSeries:20,fullTitle:"Human Microbiome",editors:[{id:"199461",title:"Prof.",name:"Natalia V.",middleName:null,surname:"Beloborodova",slug:"natalia-v.-beloborodova",fullName:"Natalia V. Beloborodova",profilePictureURL:"https://mts.intechopen.com/storage/users/199461/images/system/199461.jpg",institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9731",title:"Oxidoreductase",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9731.jpg",slug:"oxidoreductase",publishedDate:"February 17th 2021",editedByType:"Edited by",bookSignature:"Mahmoud Ahmed Mansour",hash:"852e6f862c85fc3adecdbaf822e64e6e",volumeInSeries:19,fullTitle:"Oxidoreductase",editors:[{id:"224662",title:"Prof.",name:"Mahmoud Ahmed",middleName:null,surname:"Mansour",slug:"mahmoud-ahmed-mansour",fullName:"Mahmoud Ahmed Mansour",profilePictureURL:"https://mts.intechopen.com/storage/users/224662/images/system/224662.jpg",institutionString:"King Saud bin Abdulaziz University for Health Sciences",institution:{name:"King Saud bin Abdulaziz University for Health Sciences",institutionURL:null,country:{name:"Saudi Arabia"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9742",title:"Ubiquitin",subtitle:"Proteasome Pathway",coverURL:"https://cdn.intechopen.com/books/images_new/9742.jpg",slug:"ubiquitin-proteasome-pathway",publishedDate:"December 9th 2020",editedByType:"Edited by",bookSignature:"Xianquan Zhan",hash:"af6880d3a5571da1377ac8f6373b9e82",volumeInSeries:18,fullTitle:"Ubiquitin - Proteasome Pathway",editors:[{id:"223233",title:"Prof.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan",profilePictureURL:"https://mts.intechopen.com/storage/users/223233/images/system/223233.png",institutionString:"Shandong First Medical University",institution:{name:"Affiliated Hospital of Shandong Academy of Medical Sciences",institutionURL:null,country:{name:"China"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9002",title:"Glutathione System and Oxidative Stress in Health and Disease",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9002.jpg",slug:"glutathione-system-and-oxidative-stress-in-health-and-disease",publishedDate:"August 26th 2020",editedByType:"Edited by",bookSignature:"Margarete Dulce Bagatini",hash:"127defed0a50ad5ed92338dc96e1e10e",volumeInSeries:17,fullTitle:"Glutathione System and Oxidative Stress in Health and Disease",editors:[{id:"217850",title:"Dr.",name:"Margarete Dulce",middleName:null,surname:"Bagatini",slug:"margarete-dulce-bagatini",fullName:"Margarete Dulce Bagatini",profilePictureURL:"https://mts.intechopen.com/storage/users/217850/images/system/217850.jpeg",institutionString:"Universidade Federal da Fronteira Sul",institution:{name:"Universidade Federal da Fronteira Sul",institutionURL:null,country:{name:"Brazil"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Proteomics",value:18,count:3},{group:"subseries",caption:"Metabolism",value:17,count:6},{group:"subseries",caption:"Cell and Molecular Biology",value:14,count:8},{group:"subseries",caption:"Chemical Biology",value:15,count:10}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:3},{group:"publicationYear",caption:"2021",value:2021,count:7},{group:"publicationYear",caption:"2020",value:2020,count:12},{group:"publicationYear",caption:"2019",value:2019,count:3},{group:"publicationYear",caption:"2018",value:2018,count:2}],authors:{paginationCount:301,paginationItems:[{id:"116250",title:"Dr.",name:"Nima",middleName:null,surname:"Rezaei",slug:"nima-rezaei",fullName:"Nima Rezaei",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/116250/images/system/116250.jpg",biography:"Professor Nima Rezaei obtained an MD from Tehran University of Medical Sciences, Iran. He also obtained an MSc in Molecular and Genetic Medicine, and a Ph.D. in Clinical Immunology and Human Genetics from the University of Sheffield, UK. He also completed a short-term fellowship in Pediatric Clinical Immunology and Bone Marrow Transplantation at Newcastle General Hospital, England. Dr. Rezaei is a Full Professor of Immunology and Vice Dean of International Affairs and Research, at the School of Medicine, Tehran University of Medical Sciences, and the co-founder and head of the Research Center for Immunodeficiencies. He is also the founding president of the Universal Scientific Education and Research Network (USERN). Dr. Rezaei has directed more than 100 research projects and has designed and participated in several international collaborative projects. He is an editor, editorial assistant, or editorial board member of more than forty international journals. He has edited more than 50 international books, presented more than 500 lectures/posters in congresses/meetings, and published more than 1,100 scientific papers in international journals.",institutionString:"Tehran University of Medical Sciences",institution:{name:"Tehran University of Medical Sciences",country:{name:"Iran"}}},{id:"180733",title:"Dr.",name:"Jean",middleName:null,surname:"Engohang-Ndong",slug:"jean-engohang-ndong",fullName:"Jean Engohang-Ndong",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180733/images/system/180733.png",biography:"Dr. Jean Engohang-Ndong was born and raised in Gabon. After obtaining his Associate Degree of Science at the University of Science and Technology of Masuku, Gabon, he continued his education in France where he obtained his BS, MS, and Ph.D. in Medical Microbiology. He worked as a post-doctoral fellow at the Public Health Research Institute (PHRI), Newark, NJ for four years before accepting a three-year faculty position at Brigham Young University-Hawaii. Dr. Engohang-Ndong is a tenured faculty member with the academic rank of Full Professor at Kent State University, Ohio, where he teaches a wide range of biological science courses and pursues his research in medical and environmental microbiology. Recently, he expanded his research interest to epidemiology and biostatistics of chronic diseases in Gabon.",institutionString:"Kent State University",institution:{name:"Kent State University",country:{name:"United States of America"}}},{id:"188773",title:"Prof.",name:"Emmanuel",middleName:null,surname:"Drouet",slug:"emmanuel-drouet",fullName:"Emmanuel Drouet",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/188773/images/system/188773.png",biography:"Emmanuel Drouet, PharmD, is a Professor of Virology at the Faculty of Pharmacy, the University Grenoble-Alpes, France. As a head scientist at the Institute of Structural Biology in Grenoble, Dr. Drouet’s research investigates persisting viruses in humans (RNA and DNA viruses) and the balance with our host immune system. He focuses on these viruses’ effects on humans (both their impact on pathology and their symbiotic relationships in humans). He has an excellent track record in the herpesvirus field, and his group is engaged in clinical research in the field of Epstein-Barr virus diseases. He is the editor of the online Encyclopedia of Environment and he coordinates the Universal Health Coverage education program for the BioHealth Computing Schools of the European Institute of Science.",institutionString:null,institution:{name:"Grenoble Alpes University",country:{name:"France"}}},{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",biography:"Dr. Rodriguez-Morales is an expert in tropical and emerging diseases, particularly zoonotic and vector-borne diseases (especially arboviral diseases). He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},{id:"332819",title:"Dr.",name:"Chukwudi Michael",middleName:"Michael",surname:"Egbuche",slug:"chukwudi-michael-egbuche",fullName:"Chukwudi Michael Egbuche",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/332819/images/14624_n.jpg",biography:"I an Dr. Chukwudi Michael Egbuche. I am a Senior Lecturer in the Department of Parasitology and Entomology, Nnamdi Azikiwe University, Awka.",institutionString:null,institution:{name:"Nnamdi Azikiwe University",country:{name:"Nigeria"}}},{id:"284232",title:"Mr.",name:"Nikunj",middleName:"U",surname:"Tandel",slug:"nikunj-tandel",fullName:"Nikunj Tandel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/284232/images/8275_n.jpg",biography:'Mr. Nikunj Tandel has completed his Master\'s degree in Biotechnology from VIT University, India in the year of 2012. He is having 8 years of research experience especially in the field of malaria epidemiology, immunology, and nanoparticle-based drug delivery system against the infectious diseases, autoimmune disorders and cancer. He has worked for the NIH funded-International Center of Excellence in Malaria Research project "Center for the study of complex malaria in India (CSCMi)" in collaboration with New York University. The preliminary objectives of the study are to understand and develop the evidence-based tools and interventions for the control and prevention of malaria in different sites of the INDIA. Alongside, with the help of next-generation genomics study, the team has studied the antimalarial drug resistance in India. Further, he has extended his research in the development of Humanized mice for the study of liver-stage malaria and identification of molecular marker(s) for the Artemisinin resistance. At present, his research focuses on understanding the role of B cells in the activation of CD8+ T cells in malaria. Received the CSIR-SRF (Senior Research Fellow) award-2018, FIMSA (Federation of Immunological Societies of Asia-Oceania) Travel Bursary award to attend the IUIS-IIS-FIMSA Immunology course-2019',institutionString:"Nirma University",institution:{name:"Nirma University",country:{name:"India"}}},{id:"334383",title:"Ph.D.",name:"Simone",middleName:"Ulrich",surname:"Ulrich Picoli",slug:"simone-ulrich-picoli",fullName:"Simone Ulrich Picoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334383/images/15919_n.jpg",biography:"Graduated in Pharmacy from Universidade Luterana do Brasil (1999), Master in Agricultural and Environmental Microbiology from Federal University of Rio Grande do Sul (2002), Specialization in Clinical Microbiology from Universidade de São Paulo, USP (2007) and PhD in Sciences in Gastroenterology and Hepatology (2012). She is currently an Adjunct Professor at Feevale University in Medicine and Biomedicine courses and a permanent professor of the Academic Master\\'s Degree in Virology. She has experience in the field of Microbiology, with an emphasis on Bacteriology, working mainly on the following topics: bacteriophages, bacterial resistance, clinical microbiology and food microbiology.",institutionString:null,institution:{name:"Universidade Feevale",country:{name:"Brazil"}}},{id:"229220",title:"Dr.",name:"Amjad",middleName:"Islam",surname:"Aqib",slug:"amjad-aqib",fullName:"Amjad Aqib",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229220/images/system/229220.png",biography:"Dr. Amjad Islam Aqib obtained a DVM and MSc (Hons) from University of Agriculture Faisalabad (UAF), Pakistan, and a PhD from the University of Veterinary and Animal Sciences Lahore, Pakistan. Dr. Aqib joined the Department of Clinical Medicine and Surgery at UAF for one year as an assistant professor where he developed a research laboratory designated for pathogenic bacteria. Since 2018, he has been Assistant Professor/Officer in-charge, Department of Medicine, Manager Research Operations and Development-ORIC, and President One Health Club at Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan. He has nearly 100 publications to his credit. His research interests include epidemiological patterns and molecular analysis of antimicrobial resistance and modulation and vaccine development against animal pathogens of public health concern.",institutionString:"Cholistan University of Veterinary and Animal Sciences",institution:null},{id:"62900",title:"Prof.",name:"Fethi",middleName:null,surname:"Derbel",slug:"fethi-derbel",fullName:"Fethi Derbel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/62900/images/system/62900.jpeg",biography:"Professor Fethi Derbel was born in 1960 in Tunisia. He received his medical degree from the Sousse Faculty of Medicine at Sousse, University of Sousse, Tunisia. He completed his surgical residency in General Surgery at the University Hospital Farhat Hached of Sousse and was a member of the Unit of Liver Transplantation in the University of Rennes, France. He then worked in the Department of Surgery at the Sahloul University Hospital in Sousse. Professor Derbel is presently working at the Clinique les Oliviers, Sousse, Tunisia. His hospital activities are mostly concerned with laparoscopic, colorectal, pancreatic, hepatobiliary, and gastric surgery. He is also very interested in hernia surgery and performs ventral hernia repairs and inguinal hernia repairs. He has been a member of the GREPA and Tunisian Hernia Society (THS). During his residency, he managed patients suffering from diabetic foot, and he was very interested in this pathology. For this reason, he decided to coordinate a book project dealing with the diabetic foot. Professor Derbel has published many articles in journals and collaborates intensively with IntechOpen Access Publisher as an editor.",institutionString:"Clinique les Oliviers",institution:null},{id:"300144",title:"Dr.",name:"Meriem",middleName:null,surname:"Braiki",slug:"meriem-braiki",fullName:"Meriem Braiki",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/300144/images/system/300144.jpg",biography:"Dr. Meriem Braiki is a specialist in pediatric surgeon from Tunisia. She was born in 1985. She received her medical degree from the University of Medicine at Sousse, Tunisia. She achieved her surgical residency training periods in Pediatric Surgery departments at University Hospitals in Monastir, Tunis and France.\r\nShe is currently working at the Pediatric surgery department, Sidi Bouzid Hospital, Tunisia. Her hospital activities are mostly concerned with laparoscopic, parietal, urological and digestive surgery. She has published several articles in diffrent journals.",institutionString:"Sidi Bouzid Regional Hospital",institution:null},{id:"229481",title:"Dr.",name:"Erika M.",middleName:"Martins",surname:"de Carvalho",slug:"erika-m.-de-carvalho",fullName:"Erika M. de Carvalho",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229481/images/6397_n.jpg",biography:null,institutionString:null,institution:{name:"Oswaldo Cruz Foundation",country:{name:"Brazil"}}},{id:"186537",title:"Prof.",name:"Tonay",middleName:null,surname:"Inceboz",slug:"tonay-inceboz",fullName:"Tonay Inceboz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/186537/images/system/186537.jfif",biography:"I was graduated from Ege University of Medical Faculty (Turkey) in 1988 and completed his Med. PhD degree in Medical Parasitology at the same university. I became an Associate Professor in 2008 and Professor in 2014. I am currently working as a Professor at the Department of Medical Parasitology at Dokuz Eylul University, Izmir, Turkey.\n\nI have given many lectures, presentations in different academic meetings. I have more than 60 articles in peer-reviewed journals, 18 book chapters, 1 book editorship.\n\nMy research interests are Echinococcus granulosus, Echinococcus multilocularis (diagnosis, life cycle, in vitro and in vivo cultivation), and Trichomonas vaginalis (diagnosis, PCR, and in vitro cultivation).",institutionString:"Dokuz Eylül University",institution:{name:"Dokuz Eylül University",country:{name:"Turkey"}}},{id:"71812",title:"Prof.",name:"Hanem Fathy",middleName:"Fathy",surname:"Khater",slug:"hanem-fathy-khater",fullName:"Hanem Fathy Khater",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/71812/images/1167_n.jpg",biography:"Prof. Khater is a Professor of Parasitology at Benha University, Egypt. She studied for her doctoral degree, at the Department of Entomology, College of Agriculture, Food and Natural Resources, University of Missouri, Columbia, USA. She has completed her Ph.D. degrees in Parasitology in Egypt, from where she got the award for “the best scientific Ph.D. dissertation”. She worked at the School of Biological Sciences, Bristol, England, the UK in controlling insects of medical and veterinary importance as a grant from Newton Mosharafa, the British Council. Her research is focused on searching of pesticides against mosquitoes, house flies, lice, green bottle fly, camel nasal botfly, soft and hard ticks, mites, and the diamondback moth as well as control of several parasites using safe and natural materials to avoid drug resistances and environmental contamination.",institutionString:null,institution:{name:"Banha University",country:{name:"Egypt"}}},{id:"99780",title:"Prof.",name:"Omolade",middleName:"Olayinka",surname:"Okwa",slug:"omolade-okwa",fullName:"Omolade Okwa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/99780/images/system/99780.jpg",biography:"Omolade Olayinka Okwa is presently a Professor of Parasitology at Lagos State University, Nigeria. She has a PhD in Parasitology (1997), an MSc in Cellular Parasitology (1992), and a BSc (Hons) Zoology (1990) all from the University of Ibadan, Nigeria. She teaches parasitology at the undergraduate and postgraduate levels. She was a recipient of a Commonwealth fellowship supported by British Council tenable at the Centre for Entomology and Parasitology (CAEP), Keele University, United Kingdom between 2004 and 2005. She was awarded an Honorary Visiting Research Fellow at the same university from 2005 to 2007. \nShe has been an external examiner to the Department of Veterinary Microbiology and Parasitology, University of Ibadan, MSc programme between 2010 and 2012. She is a member of the Nigerian Society of Experimental Biology (NISEB), Parasitology and Public Health Society of Nigeria (PPSN), Science Association of Nigeria (SAN), Zoological Society of Nigeria (ZSN), and is Vice Chairperson of the Organisation of Women in Science (OWSG), LASU chapter. She served as Head of Department of Zoology and Environmental Biology, Lagos State University from 2007 to 2010 and 2014 to 2016. She is a reviewer for several local and international journals such as Unilag Journal of Science, Libyan Journal of Medicine, Journal of Medicine and Medical Sciences, and Annual Research and Review in Science. \nShe has authored 45 scientific research publications in local and international journals, 8 scientific reviews, 4 books, and 3 book chapters, which includes the books “Malaria Parasites” and “Malaria” which are IntechOpen access publications.",institutionString:"Lagos State University",institution:{name:"Lagos State University",country:{name:"Nigeria"}}},{id:"273100",title:"Dr.",name:"Vijay",middleName:null,surname:"Gayam",slug:"vijay-gayam",fullName:"Vijay Gayam",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/273100/images/system/273100.jpeg",biography:"Dr. Vijay Bhaskar Reddy Gayam is currently practicing as an internist at Interfaith Medical Center in Brooklyn, New York, USA. He is also a Clinical Assistant Professor at the SUNY Downstate University Hospital and Adjunct Professor of Medicine at the American University of Antigua. He is a holder of an M.B.B.S. degree bestowed to him by Osmania Medical College and received his M.D. at Interfaith Medical Center. His career goals thus far have heavily focused on direct patient care, medical education, and clinical research. He currently serves in two leadership capacities; Assistant Program Director of Medicine at Interfaith Medical Center and as a Councilor for the American\r\nFederation for Medical Research. As a true academician and researcher, he has more than 50 papers indexed in international peer-reviewed journals. He has also presented numerous papers in multiple national and international scientific conferences. His areas of research interest include general internal medicine, gastroenterology and hepatology. He serves as an editor, editorial board member and reviewer for multiple international journals. His research on Hepatitis C has been very successful and has led to multiple research awards, including the 'Equity in Prevention and Treatment Award” from the New York Department of Health Viral Hepatitis Symposium (2018) and the 'Presidential Poster Award” awarded to him by the American College of Gastroenterology (2018). He was also awarded 'Outstanding Clinician in General Medicine” by Venus International Foundation for his extensive research expertise and services, perform over and above the standard expected in the advancement of healthcare, patient safety and quality of care.",institutionString:"Interfaith Medical Center",institution:{name:"Interfaith Medical Center",country:{name:"United States of America"}}},{id:"93517",title:"Dr.",name:"Clement",middleName:"Adebajo",surname:"Meseko",slug:"clement-meseko",fullName:"Clement Meseko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/93517/images/system/93517.jpg",biography:"Dr. Clement Meseko obtained DVM and PhD degree in Veterinary Medicine and Virology respectively. He has worked for over 20 years in both private and public sectors including the academia, contributing to knowledge and control of infectious disease. Through the application of epidemiological skill, classical and molecular virological skills, he investigates viruses of economic and public health importance for the mitigation of the negative impact on people, animal and the environment in the context of Onehealth. \r\nDr. Meseko’s field experience on animal and zoonotic diseases and pathogen dynamics at the human-animal interface over the years shaped his carrier in research and scientific inquiries. He has been part of the investigation of Highly Pathogenic Avian Influenza incursions in sub Saharan Africa and monitors swine Influenza (Pandemic influenza Virus) agro-ecology and potential for interspecies transmission. He has authored and reviewed a number of journal articles and book chapters.",institutionString:"National Veterinary Research Institute",institution:{name:"National Veterinary Research Institute",country:{name:"Nigeria"}}},{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",country:{name:"India"}}},{id:"94928",title:"Dr.",name:"Takuo",middleName:null,surname:"Mizukami",slug:"takuo-mizukami",fullName:"Takuo Mizukami",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94928/images/6402_n.jpg",biography:null,institutionString:null,institution:{name:"National Institute of Infectious Diseases",country:{name:"Japan"}}},{id:"233433",title:"Dr.",name:"Yulia",middleName:null,surname:"Desheva",slug:"yulia-desheva",fullName:"Yulia Desheva",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/233433/images/system/233433.png",biography:"Dr. Yulia Desheva is a leading researcher at the Institute of Experimental Medicine, St. Petersburg, Russia. She is a professor in the Stomatology Faculty, St. Petersburg State University. She has expertise in the development and evaluation of a wide range of live mucosal vaccines against influenza and bacterial complications. Her research interests include immunity against influenza and COVID-19 and the development of immunization schemes for high-risk individuals.",institutionString:'Federal State Budgetary Scientific Institution "Institute of Experimental Medicine"',institution:null},{id:"238958",title:"Mr.",name:"Atamjit",middleName:null,surname:"Singh",slug:"atamjit-singh",fullName:"Atamjit Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/238958/images/6575_n.jpg",biography:null,institutionString:null,institution:null},{id:"333753",title:"Dr.",name:"Rais",middleName:null,surname:"Ahmed",slug:"rais-ahmed",fullName:"Rais Ahmed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/333753/images/20168_n.jpg",biography:null,institutionString:null,institution:null},{id:"252058",title:"M.Sc.",name:"Juan",middleName:null,surname:"Sulca",slug:"juan-sulca",fullName:"Juan Sulca",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252058/images/12834_n.jpg",biography:null,institutionString:null,institution:null},{id:"191392",title:"Dr.",name:"Marimuthu",middleName:null,surname:"Govindarajan",slug:"marimuthu-govindarajan",fullName:"Marimuthu Govindarajan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/191392/images/5828_n.jpg",biography:"Dr. M. Govindarajan completed his BSc degree in Zoology at Government Arts College (Autonomous), Kumbakonam, and MSc, MPhil, and PhD degrees at Annamalai University, Annamalai Nagar, Tamil Nadu, India. He is serving as an assistant professor at the Department of Zoology, Annamalai University. His research interests include isolation, identification, and characterization of biologically active molecules from plants and microbes. He has identified more than 20 pure compounds with high mosquitocidal activity and also conducted high-quality research on photochemistry and nanosynthesis. He has published more than 150 studies in journals with impact factor and 2 books in Lambert Academic Publishing, Germany. He serves as an editorial board member in various national and international scientific journals.",institutionString:null,institution:null},{id:"274660",title:"Dr.",name:"Damodar",middleName:null,surname:"Paudel",slug:"damodar-paudel",fullName:"Damodar Paudel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/274660/images/8176_n.jpg",biography:"I am DrDamodar Paudel,currently working as consultant Physician in Nepal police Hospital.",institutionString:null,institution:null},{id:"241562",title:"Dr.",name:"Melvin",middleName:null,surname:"Sanicas",slug:"melvin-sanicas",fullName:"Melvin Sanicas",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/241562/images/6699_n.jpg",biography:null,institutionString:null,institution:null},{id:"337446",title:"Dr.",name:"Maria",middleName:null,surname:"Zavala-Colon",slug:"maria-zavala-colon",fullName:"Maria Zavala-Colon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Puerto Rico, Medical Sciences Campus",country:{name:"United States of America"}}},{id:"338856",title:"Mrs.",name:"Nur Alvira",middleName:null,surname:"Pascawati",slug:"nur-alvira-pascawati",fullName:"Nur Alvira Pascawati",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universitas Respati Yogyakarta",country:{name:"Indonesia"}}},{id:"441116",title:"Dr.",name:"Jovanka M.",middleName:null,surname:"Voyich",slug:"jovanka-m.-voyich",fullName:"Jovanka M. Voyich",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Montana State University",country:{name:"United States of America"}}},{id:"330412",title:"Dr.",name:"Muhammad",middleName:null,surname:"Farhab",slug:"muhammad-farhab",fullName:"Muhammad Farhab",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Agriculture Faisalabad",country:{name:"Pakistan"}}},{id:"349495",title:"Dr.",name:"Muhammad",middleName:null,surname:"Ijaz",slug:"muhammad-ijaz",fullName:"Muhammad Ijaz",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Veterinary and Animal Sciences",country:{name:"Pakistan"}}}]}},subseries:{item:{id:"26",type:"subseries",title:"Machine Learning and Data Mining",keywords:"Intelligent Systems, Machine Learning, Data Science, Data Mining, Artificial Intelligence",scope:"The scope of machine learning and data mining is immense and is growing every day. It has become a massive part of our daily lives, making predictions based on experience, making this a fascinating area that solves problems that otherwise would not be possible or easy to solve. This topic aims to encompass algorithms that learn from experience (supervised and unsupervised), improve their performance over time and enable machines to make data-driven decisions. It is not limited to any particular applications, but contributions are encouraged from all disciplines.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/26.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11422,editor:{id:"24555",title:"Dr.",name:"Marco Antonio",middleName:null,surname:"Aceves Fernandez",slug:"marco-antonio-aceves-fernandez",fullName:"Marco Antonio Aceves Fernandez",profilePictureURL:"https://mts.intechopen.com/storage/users/24555/images/system/24555.jpg",biography:"Dr. Marco Antonio Aceves Fernandez obtained his B.Sc. (Eng.) in Telematics from the Universidad de Colima, Mexico. He obtained both his M.Sc. and Ph.D. from the University of Liverpool, England, in the field of Intelligent Systems. He is a full professor at the Universidad Autonoma de Queretaro, Mexico, and a member of the National System of Researchers (SNI) since 2009. Dr. Aceves Fernandez has published more than 80 research papers as well as a number of book chapters and congress papers. He has contributed in more than 20 funded research projects, both academic and industrial, in the area of artificial intelligence, ranging from environmental, biomedical, automotive, aviation, consumer, and robotics to other applications. He is also a honorary president at the National Association of Embedded Systems (AMESE), a senior member of the IEEE, and a board member of many institutions. His research interests include intelligent and embedded systems.",institutionString:"Universidad Autonoma de Queretaro",institution:{name:"Autonomous University of Queretaro",institutionURL:null,country:{name:"Mexico"}}},editorTwo:null,editorThree:null,series:{id:"14",title:"Artificial Intelligence",doi:"10.5772/intechopen.79920",issn:"2633-1403"},editorialBoard:[{id:"43680",title:"Prof.",name:"Ciza",middleName:null,surname:"Thomas",slug:"ciza-thomas",fullName:"Ciza Thomas",profilePictureURL:"https://mts.intechopen.com/storage/users/43680/images/system/43680.jpeg",institutionString:null,institution:{name:"Government of Kerala",institutionURL:null,country:{name:"India"}}},{id:"16614",title:"Prof.",name:"Juan Ignacio",middleName:null,surname:"Guerrero Alonso",slug:"juan-ignacio-guerrero-alonso",fullName:"Juan Ignacio Guerrero Alonso",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6HB8QAM/Profile_Picture_1627901127555",institutionString:null,institution:{name:"University of Seville",institutionURL:null,country:{name:"Spain"}}},{id:"3095"