Impairment of functional health in neck cancer.
\r\n\tWe need such information of the environmental indicators day and night, from the crowded cities and the most remote locations. Therefore the study, development, and application of automated sensing systems have been booming during the last decades and the progress in this field is really fast.
\r\n\r\n\tThe current book intends to provide the reader with the most recent trends in the development of sensing technologies for environmental control and monitoring, application of these novel technologies for the detection and monitoring of different environmental indicators, but also identification of hazardous chemical compounds and pathogens, and to introduce various aspects of using the online sensing data for decision-making in different fields of social life.
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Cancer is defined as the growth of abnormal cell structures in the body uncontrollably, without purpose, and with a large number. Cancer develops faster when the body’s normal defense and control mechanisms do not work. Old cells do not die; instead, they become uncontrolled and replace new cells that are abnormal. These abnormal cells may be called a tumor, while some cancers do not form tumors such as leukemia [1]. Cancer can be anywhere in the body. Cancer is a chronic disease of various types and characteristics in all ages and genders. According to the literature, the most common cancer is breast cancer in females and prostate cancer in males. Moreover, lung and colorectal cancer affect both men and women at high rates [2]. The most common types of cancer in children between 0 and 14 years of age are acute lymphocytic leukemia (ALL), brain and other central nervous system (CNS) tumors, and neuroblastoma. Although pediatric cancer mortality rates have declined by about 70% in the last four decades, it is still one of the most common causes of death in children [3].
There are five primary categories of cancer: carcinomas, sarcomas, leukemia, lymphomas, and central nervous system cancers. This categorization is made according to the body structure involved. For example, carcinomas begin in the skin or tissues, whereas sarcomas start in the bone, cartilage, fat, muscle, or other connective tissues. Leukemia develops in the blood and bone marrow, lymphomas start in the immune system, and central nervous system cancers start in the brain and spinal cord [4].
The survival rate after cancer treatment is increasing day by day due to advances in children, adolescents, and adults [5, 6]. Cancer survivors also can face the risk of cancer recurrence, metastases, or symptoms such as cancer-related pain, fatigue, stress, or lymphedema, etc. More than 60% of cancer survivors with ages between 5 and 19 years reported at least one serious symptom [7]. Some of the treatment options for cancer clients include surgery, chemotherapy, hormonal therapy, radiotherapy, immunotherapy, and targeted therapy. These treatments contain some risks that are closely related to the individual and the treatment dosage. Some side effects of treatments such as fatigue, pain, cognitive problems, decreased bone density, weight loss, and stressful psychosocial problems as well as hot pressures may occur [8]. It is known that due to these side effects, there is a decrease especially in the physical functions, daily activities of life (ADL), and quality of life in clients with cancer [9].
Occupational therapists (OTs) specialized in oncology does not only need to have high quality of skills but also knowledge about cancer, side effects, and evaluation of the treatments of cancer. This perspective requires a holistic and client-centered approach to provide personal care. OTs working in oncological rehabilitation aim to increase quality of life by facilitating physical, mental, emotional, social, occupational and cognitive needs, goal setting, and participation in meaningful occupations [10]. The main goal of OTs is to provide clients to participate in daily activities of life (ADL). OTs change their occupation or environment to better support occupational engagement in an interdisciplinary team concept. With oncologic rehabilitation, care is given to various age groups in a variety of care settings, including hospital, home, inpatient palliative care, or community-based services [11].
Cancer rehabilitation is defined by Cromes as “helping a client with cancer to help to reach the maximum physical, social, psychological, and vocational functioning within the limits of disease and treatments” [12]. The functioning is important while engaging in activity and is related with all performance components [13]. In a more contemporary view, the function is a broad vision that encompasses the physical, emotional, cognitive, and psychological states of the individual [14]. The World Health Organization’s International Functioning, Disability and Health Classification (ICF) defines a framework in which this multidimensional or biopsychosocial approach focuses on an extensive understanding of the interactions between function, capacity, and performance [13–15]. Cancer treatment itself also can lead to functional problems or impairments in physical, sensorial, or cognitive (body functions and structures), potentially leading to limitations in ADL or instrumental ADL (activity) and participation restriction (participation) [16]. Therefore, as ICF covers all of these domains, it suggests framework and approach regarding diagnosis and evaluation. This framework can also guide treatment programs [17].
Cancer rehabilitation goals are classified as restorative, supportive, palliative, and preventive according to progression of cancer. Generally, restorative care purposes at maximal recovery of residual function of the client. Supportive care aims to increase daily life and mobility by using effective methods such as reducing functional difficulties and compensating for permanent deficits. Palliative care reduces symptoms such as pain and shortness of breath. Preventive care includes in the area of power maintenance and movement after treatment. This process starts right after the diagnosis [18].
Client should be evaluated in terms of goal-oriented activity performance and participation in all contextual areas. Thus, OTs can provide a top-down approach to the clients [19]. Table 1 shows an example of functional health impairment areas in neck cancer that should be analyzed by OTs [20]. In occupational therapy (OT), rehabilitation generally focuses on these topics:
Symptom control
Activity training
Client education
Motor training
Sensory training
Cognitive training
Vocational rehabilitation
Sensation of pain Energy and innerdrive functions Emotional functions Voice functions Respiration functions Swallowing functions Structure of mouth—pharynx-larynx-head and neck region |
Daily routine activity (Self-care-Eating-Drinking) Social activity (Family and friends relationships) Productivity activity (Economic self-sufficiency-preparing foods) |
Type a or b personality İnterest Motivation level |
Products or substances for personal consumption Immediate family Health professionals Work environment |
Impairment of functional health in neck cancer.
Some clients experience symptoms during the first phase of diagnosis or treatment, while others experience these symptoms due to side effects or long-term outcome of treatment during the treatment phase. The appearance of symptoms can be basically examined in five different phases. The pretreatment phase is first experienced with symptoms of fatigue, pain, and anxiety. In this phase, the client will have difficulty in accepting the idea of the disease, their sleep patterns and routines begin to deteriorate, and problems occur in occupational and social relationships. The second phase is the primary treatment phase; in addition to the symptoms mentioned above, some other symptoms such as inappetency, fever, vomiting, dry mouth, etc. can occur as a result of chemotherapy or other modalities. ADL are interrupted. The post-treatment phase is the third one; the client with cancer experience treatment-related symptoms such as pain, weakness, or constipation after surgery. The influence on the activities and routines are very apparent at this phase. The fourth phase, where the symptoms experienced due to tumor growth occur, is the recurrence phase. Clients with cancer often feel depressive, anxious, fear, and unhappy for repetition. ADL and routines are disrupted with negative emotions and thoughts about their future. In the last phase, the end-of-life phase, the most common symptoms are fear of death and alienation to everything. Client usually cannot even get out of the bed and have lost all interest and the desire to live [13].
Symptoms are multidimensional and changeable in cancer clients. The OT’s role in management of symptoms is crucial and important. They must maintain up-to-date professional knowledge of the symptoms and its treatments. They must also investigate the meaning and the impact of the symptom not only to the individual, but also to the caregivers. Besides, in the following sections of this chapter, every title includes client and their family educations for these symptoms, especially. They must search how this situation limits them in carrying out their required objectives in life. Thus, as a priority, realistic and achievable intervention plan can be made for people with cancer to control the symptoms. There are some approaches to control symptoms such as problem-solving strategies, restoration activity, compensation activity, and environmental modification that will be defined in the following sections.
Cooper describes problem solving as “analyzing of the client’s needs and enabling the client to cope with dysfunction” in approach to symptom control. OT must help to identify physical, emotional, social, and psychological problems and try to resolve them. For solving the problems caused by the symptoms can include: identifying the main problem, discussing another event that may contribute to the induction of the problem, brain storming through occupational therapy models to cope with the problems, setting achievable goals for individual, discussing methods—techniques to cope with the problems, practicing the developed strategies, and checking up the results of problem solving. OT can use problem-solving strategies mostly for clients with HIV/AIDS, cancer, and palliative care [21].
If cancer client have some difficulties on lifestyle, fatigue, and self-esteem, OT could help them to determine their priorities of life, to use energy levels, to recognize that a client’s inner feelings and values, to change behavior, and to adapt to their changed lifestyle.
Clients have different activities related to their routines in their life. The focus of the restorative approach is to develop client skills and abilities or increase the activity performance and participation of the client with cancer. In this stage, grading of the activity level can be done according to the following parameters [22]:
Physical assistance: providing physical support with relaxation and breath training to manage symptoms such as fatigue or anxiety. Thus, patients’ skill to complete task may be increased. You must remember that the support does not mean that caregiver do all of the tasks instead of the client.
Supervision and cuing: contain a number and types of cues to support client. It can be supplemented with verbal, tactile, and written material tips to help cognitive impairment of cancer-induced client activities.
Activity demands: the activity can be changed due to the necessity of performance skills. It will be better to select an activity with appropriate level demands for clients. In activity education, the motor and cognitive demands of the activity can be increased step by step.
Sequencing of activity: recognize and determine the client’s activity priority. Clients’ motivation should be supported to participate in activities. The number of steps in tasks and the total number of steps can be increased. Thus, cancer client can complete the activity easily with motivation, without symptoms.
Type of activity: during activity education, activities can be graded from familiar to unfamiliar or from former to new. This method can help the clients to decrease cancer-related symptoms.
Environment: the activity environment can affect participation in activities. Usually due to the treatments they receive, they are affected by the environment in which they perform activities in connection with their roles. They are often present in isolated environments such as hospitals and homes. In order to reduce symptoms and improve the performance of the activity, awareness of the activities that they can perform in the environment they are in is extremely important in terms of occupational therapy intervention.
The compensation approach focuses on using the patients’ skills to achieve the highest possible stage of functioning in the activities. Despite the symptoms, OTs may teach new methods to increase performances. If the client still needs help, OTs can suggest using assistive equipment. These equipments can decrease symptoms, such as fatigue and pain of cancer, and increase participation in the activities.
Environmental modifications consist of compensation, modification, and adaptation strategy. The compensation approach directly influences client functioning. However, environmental modification approach influences patients’ functioning indirectly. OT could give advice to the client with cancer to redesign environments, such as home, work, and school, where the client wants to be. Modifications must be low cost and easily accessible.
Nearly over 300,000 children develop cancer worldwide each year [23]. As many as two-thirds of children with childhood cancer are likely to experience at least one side effect, one-fourth of survivors experiencing a late effect that is severe or life threatening [24]. There are many studies showing that childhood cancer client experience many specific squeal after cancer diagnosis and treatment such as: hair loss, pain and fatigue, loss of fertility, and other changes in body image [25–27]. In children, it is important to be aware of growth and development stages in evaluation and intervention planning. Different from adults, their development can be affected in all components and more from the therapy. As children are also still dependent on caregivers, they are not fully functioning and still developing physical, social, cognitive skills, etc. Sometimes, to save life, surgeries may be harsh resulting with loss of a limb. Therefore, they may struggle to develop with that loss. The majority of the existing studies have shown that children with childhood cancer have increased anxiety, depression, and distress compared to their healthy peers and the general public [28, 29]. In a recent systematic review by Quinn et al., it is emphasized that psychological symptoms often result in impaired quality of life (QoL) [30].
Long-term treatments affect children’s ability in the areas of self-care, productivity, and leisure activity. Treatments of cancer, especially treatments, cause a decrease in motor skills [31]. Gross and fine motor skills play an important role in the development of cognitive, academic, and social skills in children [32, 33]. In childhood cancer, the basic problems can be seen in social relationships, educational attainment, and school functions such as writing skills or reading skills, etc. [33]. Understanding the degree of the motor difficulty that the child faces is important for the efforts to improve their quality of life.
Assessment is needed at the beginning and end of rehabilitation to evaluate body structure and functions, activities, and participation. As all areas are affected, the level of success in terms of rehabilitation goals can be detected by systematic evaluation. Table 2 shows the rehabilitation goals and assessment tools used by OTs in childhood cancer. It is important to recognize these rehabilitation goals while planning treatment.
Rehabilitation goals | Evaluation instruments |
---|---|
Improvement of functional disorders of the musculoskeletal system | Range of motion, muscle test |
Determining of function-related treatment goals | Goal assessment scale (GAS) |
Reducing post-surgical problems (scars discomfort, seroma) | Clinical observation |
Reducing symptoms after radiotherapy (cystitis, proctitis) | Micturition, Chair Diary |
Reducing hormone deficiency symptoms (vasomotor reactions, osteoporosis) | Visual analog scale (VAS) *Osteodensitometry must be checked |
Reducing symptoms after cytostatic chemotherapy (polyneuropathy) | Common Toxicity Criteria of the National Cancer Institute (NCI-CTC), sensitivity measurement, vibration sense |
Reduction of fatigue | The PedsQL™ Multidimensional Fatigue Scale (PedsQL–MFS), Visual Analog Scale-numeric (VAS), Faces Rating Scale |
Reducing pain | Faces Rating Scale, Visual Analog Scale- numeric (VAS), Pain Diary South California sensory Integration Tests (AYRES), Semmes Weinstein monofilament test |
Assessing sensory process | |
Improving balance | The Berg Balance Test (Berg), South California sensory Integration Tests (AYRES) |
Maintaining/increasing independence of daily life | Detailed activity analysis, Wee Functional Independence Measure (WeeFIM), Barthel Index (BI), Instrumental Activities of Daily Living Scale (IADL), Role Checklist (RL) |
Improvement of cognitive performance | Dynamic Occupational Therapy Cognitive Assessment (DOTCA), Mini mental state examination-child |
Activity Performance and Participation | Canadian Occupational Performance Measurement (COPM), Children’s Assessment of Participation and Enjoyment (CAPE), Preferences for Activities of Children (PAC), The Children’s Leisure Activities Study Survey (CLASS) |
Coping with stress and anxiety depressive states and relaxation | Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Spielberger’s State Trait Anxiety Inventory (STAI), and Visual Analog Scale (VAS) |
Increasing Gross & Fine Motor Skills | Bruininks Oseretsky Test of Motor Proficiency (BOTMP-2edition), Purdue Pegboard, Jebsen Hand Function Test, Nine Hole Peg Test |
Supporting/developing Quality of Life | SF-36, Quality of Life for Cancer Survivors, Childhood Health Assessment Questionnaire (CHAQ) |
Family or peer problems | Interview |
Reduction of insomnia | Diary |
Construction of meaning and objective perspectives | Interview |
Improving of school function | The Evaluation Tool of Children’s Handwriting (ETCH), Minnesota Handwriting Test, School Function Assessment (SFA) |
Rehabilitation goals and the evaluation instruments mostly used for childhood cancer.
It is always beneficial to use a framework while planning the treatment. As we prefer person- environment-occupation or Canadian Model of Occupational Therapy in children, we analyze all parameters according to the model. It is useful to train all skills by using play. Play is formed according to the skill loss of the children. OTs should be more creative while working with children. In literature, as we would like to increase motivation, do not bore and tire the child, all components can be trained with play [34]. The most preferred plays are jenga, monopoly, and dart throwing in our clinic. It is because children have joy while playing and these plays can be used to increase proximal stabilization, gross and fine motor skills, sensory skills, cognitive skills, social skills, and bilateral integration.
It is important for the children to gain problem-solving skills, confidence, self-esteem, etc. Therefore, children should take responsibility in treatment; parents also should let the child to participate in activities. Some brainstorming home works are useful for both child and family education. ADL training is needed, and we should be aware of the sociocultural form of the family. If the child had never learned the skill, we may teach the parameters of the activity [35]. Children should develop social skills. We may form a social environment for the child and let him/her participate in group activities. Children always develop more by playing with their peers like communication, language, etc. Environment also should be assessed and needed adaptations should be provided.
In addition, OTs should be more creative in therapy applications. They should use creativity-containing methods such as art, music, and dance therapy to increase activity performance and participation in children with cancer [36].
There are a total of 14.1 million cancer cases that result in 8.2 million deaths according to the global cancer statistics [37]. Survivors of cancers may have physical, social, cognitive, and emotional problems. For example, in breast cancer which is the most common type of woman, they might experience chronic lymphedema, sexual dysfunction, and cognitive impairment [38, 39]. As well as client with prostate cancer may experience urinary incontinence, peripheral neuropathy, weakness of muscle, sexual problems, and fatigue [22]. Among cancer survivors, psychosocial problems are prevalent and may include economic difficulties related to repetition and fear of death, anxiety and depression, feelings of alienation or isolation, job loss, and discrimination in employment [40]. Because of these reasons, researchers focus on quality of life issues after cancer treatment [41]. The common rehabilitation goals and a couple of examples of instrument for assessing the achievement of this goal are shown in Table 3.
Rehabilitation goals | Evaluation instruments |
---|---|
Increasing of physical performance | WHO Activity Index, Karnofsky Performance Score, Harvard Step Test, Ergometry, Muscle Strength Measurement (Vigorimeter, Digimax Muscle Testing), Functional Assessment of Cancer Therapy (G: General, F: Fatigue, P: Prostate-FACT) |
Reducing post-surgical problems (scars discomfort, seroma) | Clinical observation, Visual Analog Scale (VAS) |
Reducing hormone deficiency symptoms (vasomotor reactions, osteoporosis) | Clinical observation, Visual Analog Scale (VAS) |
Reducing sensory symptoms after treatments | Sensitivity Measurement, Vibration Sense, Semmes-Weinstein monofilament |
Reduction of fatigue | Multidimensional fatigue Inventory (MFI), Cancer Fatigue Scale (CFS), Piper Fatigue Scale (PFS), Functional Assessment of Cancer Therapy, Fatigue (FACT-F), Visual Analog Scale (VAS), EORTC-QLQ-C30, Fatigue Module |
Reducing pain | Visual Analog Scale (VAS), Pain Diary |
Reduction of lymphedema | Clinical observation, rating scale |
Improvement in urinary incontinence | Biofeedback, diary |
Dealing with sexual dysfunction, improvement of erectile dysfunction | Diary, International Index of Erectile Function (IIEF) |
Improvement of functional disorders of the musculoskeletal system | Range of motion Muscle strength test |
Maintaining/increasing independence of daily life | Detailed activity analysis, Functional Independence Measure (FIM), Barthel Index (BI), Instrumental Activities of Daily Living Scale (IADL), Role Checklist (RL) |
Increasing motivation and interest in activities | OQ (Occupational Questionnaire), Interest Checklist and Activity Checklist (ICAC) |
Improvement of cognitive performance | d2-test (Attention stress test), Benton test (visual memory-BT), Multiple Choice Vocabulary Intelligence Test (MWT-B), Loewenstein Occupational Therapy Cognitive Assessment (LOTCA), Mini mental state examination |
Promoting disease management, improving self-awareness and self-acceptance, emotional stabilization | EORTC, SF-36, Functional Assessment of Cancer Therapy (G: General, F: Fatigue FACT) |
Coping with stress and anxiety depressive states and relaxation | “Stress thermometer,” Hospital Anxiety and Depression Scale (HADS-D), Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Visual Analog Scale (VAS) |
Reduction of Progression Improving of Hand Function | Fear of Progression Questionnaire Purdue pegboard, Jebsen Hand Function Test |
Improving of Quality of Life | QLQ-C30, cancer-related modules |
Breakdown of family and partnership problems | Interview, Couples climate scales |
Enabling reintegration, initiating professional promotions | CIO Community Integration Questionnaire, ISSI (Interview Schedule For Social Interaction) |
Obtaining participation in life, increasing activity performance | Reintegration to Normal Living Index, Instrumental Activities of Daily Living Scale (IADL), Canadian Occupational Performance Measurement (COPM) |
Reduction of risk behavior (smoking alcohol abuse, overwork) | Life Habits Assessment (LIFE-H), Questionnaires |
Providing vocational rehabilitation | Worker Role Interview, Valpar Component Work Samples (VCWS) |
Rehabilitation goals and the evaluation instruments mostly used for adults cancer.
According to ICF parameters, Table 3 shows some examples of the rehabilitation goals and the evaluation instruments which are mostly used by OT for cancer client in adults. Clients with cancer need sensory-motor-cognitive training, breathing and relaxation training, fatigue and pain management, and vocational rehabilitation to support independent, healthy life. It is also important to promote occupational balance and appropriate planning of daily routine in adults. Different than children, adults may have more problems in gaining motivation; they are mostly very pessimistic and sometimes it is hard to initiate the rehabilitation program. Therefore, therapist should use therapeutic skills for communicating well.
In sensory training, it is good to support body image, body awareness, and deep sense. Mindfulness, body awareness training, proprioceptive-kinesthetic training can be added to rehabilitation program. Sensory education should be given for both upper and lower extremity. Many clients have problems in perception of foot sole. Sensory input should be given form planter surface of the foot. Education in upper extremity should be given in a functional manner. Materials and exercises should be selected according to the meaningful activities.
In motor training, according to the areas of weaknesses, muscle strength gain should be aimed. Clients mostly have problems in endurance and control. In hospital setting, activity training should be planned in this manner. For example, for the clients who do not wanted to participate to therapy and can only sit in bed for 5 minutes, we decided to use dart throwing exercise. We asked him to sit in a wheelchair and stand up and throw the dart. First day, he did only one throw; however, second day he stood up three times, and at the end of the week he started walking and participated to the therapy. We should always support antigravity muscles by activities. Endurance and fatigue management should be our priority, afterwards we can aim speed.
Cognitive training will differ according to the effect among cancer clients. However, mostly, programs may include memory, attention, orientation, and executive function. If the client is elderly, cognitive problems may be more visible as with ageing cognitive abilities are decreasing. In working adults, executive functioning gains importance for working skills. It is advisable to start cognitive training as quick as possible because its effect on symptom and fatigue control has been shown.
Breathing and relaxation training consist of learning breathing technique, body/mind relaxation technique, somatic experience technique, and relaxation exercises [21, 22]. The common goal of these techniques is to ensure that people are both physically and cognitively less likely to feel stressed and more comfortable to maintain and participate in their activities.
Fatigue and pain management are most important in rehabilitation. Because nearly every client struggles with fatigue and pain, and these symptoms affect treatment success. Management of these symptoms will closely influence the performance and participation of activities of individuals in their daily lives. OTs should give priority to teach the client to state, sequence, and divide the activity for them to enable to cope with these symptoms. Energy conservation techniques and activity planning should become a part of their lifestyle, so that they can keep their energy for longer or use it more appropriately. In addition, planning sleep routines and daily routines is an intervention that OTs should not forget in adult cancer clients [21].
Leisure activities can also be suggested to these clients. As we aim occupational balance, this area of occupational performance should not be forgotten. Gardening, doing hand crafts, painting, yoga, dance, and pilates are mostly preferred activities. As these activities give joy to clients, some chemicals like serotonin can be released and immune system can be supported. Therefore, we may say that these activities can also have a healing effect.
Adult client may whether continue with their old job or are ready to return to work or whether they will be able to get a new job or not. Thus, vocational rehabilitation may be needed in treatment plan. OTs can make suggestions on improving the physical, psychological, and cognitive skills of the worker about the work, and give suggestions about designing the working activity or modify the work environment.
In conclusion, occupational therapy should carry out a holistic approach including improving endurance and muscle strength, preserving energy for daily living activities, decreasing stress, improving activity performances, and participation in adults’ cancer [22, 42].
The role of occupational therapist in palliative care and hospice care is quite similar and important. In these care services, occupational therapists support mostly the secondary symptoms related to cancer client, cancer types, and treatments. End-of-life care of children and adults can include the management of physical, emotional, social or cognitive symptoms, limitations of performance, meaningful roles and activities, family, and social support. They analyze the current activity preferences and the personal and environmental resources to increase client participation. Hospice care generally has been little experienced with children, while it is mostly used as an approach to care during the last stages of life in adults [24]. The main aim of OTs is to improve the quality of life according to the values of the client and to maximize lasting functional skills [43].
OT clinical trial evaluation and interventions focus on functioning and participation by improving the abilities of cancer clients. The care of cancer client prolongs from the start of treatment to the end of the client life. They provide evidence-based interventions in inpatient care, outpatient care, education, and home care and in hospital care settings. Cancer clients may usually need support for ADL, using breathing and relaxation training, lifestyle redesigning and fatigue management, self-esteem, motor skills, cognitive therapy, vocational rehabilitation, and client and caregiver education. The OTs mainly focuses on these subjects and activity and participation restrictions in the rehabilitation community.
Nowadays, the quality of products, including services, appears the mandatory criterion that must be taken into account by companies all over the world. In order to better organize their activities, the companies design, implement, and then review business management systems.
ISO standards offer a framework that covers different areas and give companies support regarding the design and implementation of the management systems.
To ensure a certain degree of quality in all the levels and areas, the company designs and sets in place the quality management system (QMS), in accordance with the fundamentals presented in ISO 9000 [1] and the requirements given by ISO 9001 [2].
In the last decade, to have a quality system implemented in the company appears not enough to identify all the problems and solve them or to face in a reliable way the changing environment. After some time, the systems need to be evaluated in order to identify their performance. For realizing the self-assessment of the QMS, the standard ISO 9004 [3] comes in handy.
To offer a broader alternative to ISO 9004, the excellence models have been developed and reviewed to facilitate benchmarking and maturity level assessment in terms of performance [4, 5, 6, 7, 8]. One of the most developed and used Excellence Model is the European Foundation for Quality Management (EFQM) Excellence Model [4, 5, 6].
As the industry evolved taking into account the quality of products, processes, machines, and systems, another problem appeared that it is not covered in total by the tools used in order to analyze the performance (ISO 9004 [3] and Excellence Models [4, 5, 6]). The excellence models were the starting point of finding solutions for a sustainable development of companies.
In order to achieve sustainable development for a company, the three pillars, namely society (social responsibility), economic growth, and the environment protection, must be taken into account [9].
In 2010, ISO drafted and published the standard ISO 26000 [10] that offer companies’ guidelines considering two of the three pillars (society and environment). Its purpose is to harmonize the social behavior of enterprises worldwide [10, 11, 12].
An important item in sustainability is the establishing of key performance indicators and the manner in which they have to report them. To have guidelines for reporting, the Stitching Global Reporting Initiative (GRI) and ISO have developed a framework for companies presented in GRI1 Foundation [13]. The next three standards cover the part of general disclosures [14], materials [15], and economic performances [16]. The first four GRI standards are applied in all fields.
Nowadays, searching companies’ websites, more and more companies exhibit their strategy in terms of customer focus and sustainability. Moreover, sustainability strategies are promoted to increase customer loyalty showing the approaches for sustainable development so as to harmonize stakeholders into more sensitive balance between environment – human – development – policies.
One may analyze the structure of ISO standards concerning quality management, i.e., the fundamentals (ISO 9000 [1]), the requirements (ISO 9001 [2]), and the guidance for sustained success that may be considered an assessment framework and tool for the QMS maturity (ISO 9004 [3]). The QMS principles are accompanied by possible actions, these actions being translated into requirements in ISO 9001 [2]. This means that one may not focus unbalanced on one or another component of the system, the whole, as a system, appears relevant, and all aspects should be considered irrespective of the priority order selected by the organization to address the fundamental through approaches.
Once implemented, the organization may step into the next level of performance, applying the self-assessment regularly in order to define improvement plans and act accordingly. In this context, ISO 9004 offers a maturity assessment tool [3] finalized with a radar diagram for better evidence of the areas with more potential or emergency need for improvement. Such a radar, together with the detailed maturity assessment, may be used by the management team (top and middle) as a prioritizing tool for the decision-making process.
If organizations maintain into the improvement cycle according to ISO 9001 requirements, certainly certain benefits may be reported on long term, but, in order to proactive reply to the global changes, ISO standards appear too basic to release organizational adaptability and people real engagement. The management team has the option to support improvement projects, even beyond the ISO requirements, such as motivating people through different mechanisms to balance professional to private life or involvement in community responsibility projects. On short term, the tangible effect may be more satisfaction and engagement of people.
Based on the experience of different contexts, in function of the organizational capability, a significant step ahead may be embracing extended fundamentals of an excellence model, such as EFQM [3, 4] or other similar business models. Table 1 presents in comparison the fundamentals showing the consistency in progression of these principles.
Quality management principles [2] | Fundamental concepts EFQM model [4] | Fundamental concepts updated EFQM model [5] |
---|---|---|
Achieving Balanced Results | Sustaining Outstanding Results | |
Customer focus | Adding Value for Customers | Adding Value for Customers |
Leadership | Leading with Vision, Inspiration & Integrity | Leading with Vision, Inspiration & Integrity |
Engagement of people | Succeeding through People | Succeeding through the Talent of People |
Process approach | Managing by Processes | Managing with Agility |
Improvement | Nurturing Creativity & Innovation | Harnessing Creativity & Innovation |
Evidence-based decision making | ||
Relationship management | Building Partnerships | Developing Organizational Capability |
Taking Responsibility for a Sustainable Future | Creating a Sustainable Future |
Comparison of fundamentals.
Once a sound management system set in place and a deep commitment of the management team for these fundamentals, the use of the excellence model framework is naturally adopted. Even more complex, more evidence-based, more refined, and in-depth interconnected, the excellence model offers to the management team the framework for assessment on a broader and more discrete perspective in order to define action plans for improvement. Similarly, but more complex, all fundamentals should be considered, each of them having corresponding criteria and subcriteria, and the same maturing assessment is proceeded, revealing finally the areas for improvement.
The difference, but the added value of the excellence model, lies into the more refined evidence research for more organizational cells and layers, seen in the progression of PDCA (Approach – Deployment – Assessment & Refinement) of the assessment so as to identify, prioritize, and implement sustainable approaches.
Even if the model changed the role from an assessment tool [4, 5] to a framework for defining the direction so as to cocreate together with others a sustainable ecosystem [6], in order to understand the capabilities and to address the necessary changes, the assessment grid (Table 2) is given for connecting to evidences while analyzing the reality, in order to define priorities for present and future.
Type of evidences | Attributes | Rating % |
---|---|---|
Lack of indicators Lack of procedures Interfaces undefined | No evidence or anecdotal/Unable to demonstrate | 0% |
Indicators set in place, but no monitoring and connection with the approaches Improvement plan drafted Procedures for critical issues Interfaces coordination in an unformal way | Partial Conformity/Some evidence/Limited ability to demonstrate | 25% |
Improvement plan documented and monitored Procedures/processes set in place, documented and functional Functional interfaces Rare or minor disruptive processes/few or minor non-conformities Monitored indicators as decision-making process threshold/framework | Effective/Evidence/Able to demonstrate | 50% |
Regular improvement of the documented processes Regular update of procedures for better and more fluent functioning Interfaces regular monitoring together with process stakeholders | Efficient/Clear evidence/Fully able to demonstrate | 75% |
Innovative approaches set in place Practices reference for benchmarking at global level Anticipation of needs and their evolution Committed and motivated actors Continuous learning from the implemented approaches to explore perceived opportunities | Excellent/Comprehensive evidence/Recognized as global role model | 100% |
Assessment grid for enablers.
Disruptive processes appear nevertheless in any environments and nowadays change, balance, technology, transformation may not be avoided; moreover, after a long period of stop-and-start, with direction research in the pandemic time, which revealed clearly that previous solutions should be reviewed and soundly transformed, a diagnostic of the entity’s reality is needed.
The RADAR tool has been developed on the basis of the Deming cycle (Plan-Do-Check-Act) but adding the organization’s reason of existence in the ecosystem, measured through the results composed by perceptions and outcomes/outputs/indicators, all of these benchmarked versus targets.
The assessment/diagnostic tool allows the management team to analyze in depth the working style in order to manage more effective and efficient, but to enable the strategy and plans definition in clear priority and consistent follow-up. The starting point is the results aimed to achieve, once determined, approaches are set in place to deliver these results, approaches become operational through deployments, and their effectiveness, efficiency, and sustainability are assessed and refined. The assessment framework is detailed in Table 3 for enablers and Table 4 for results.
Element | Detail | Rating % | Organization reality | |
---|---|---|---|---|
What are the results aimed to achieve as follows the Strategy | Search evidence and assess | Strengths and Areas for improvement | ||
Plan and develop sound and integrated | Sound—considering relevant stakeholders needs build Approaches with real rationale and define processes to support them | Search evidence and assess | Strengths and Areas for improvement | |
Integrated—considering the Strategy to achieve the Results, build and connect the Approaches in a sustainable and synergetic structure | ||||
Implemented—approaches are implemented in relevant areas with time refinement based on the stakeholders present and future needs | Search evidence and assess | Strengths and Areas for improvement | ||
Systematic—approaches are operational and enable resilience and agility; Approaches are planned and executed soundly | ||||
Measurement—regular measurements of approaches effectiveness & efficiency, regular measurements of effectiveness & efficiency of carried out deployments, appropriate measurements selected and regularly monitored | Search evidence and assess | Strengths and Areas for improvement | ||
Learning and creativity—internal and external good practices/practices to avoid and improvement opportunities are internalized and valorized, approaches and deployments are updated with creativity | ||||
Improvement and innovation—outputs from measurements and learning and creativity are feeding evaluation, prioritization, planning and implementation of improvements and innovations | ||||
Summary per Enabler subcriterion | Consolidated rating | Strengths and Areas for improvement |
Radar assessment framework for enablers.
Element | Detail | Rating % | Organization reality |
---|---|---|---|
Results should be comprehensive, reliable, accurate and consistent with the strategy | Scope and relevance—performance seen as strategy to fulfill relevant stakeholders needs and expectations is demonstrated by coherent and sustained key results (KPI) | Search evidence in relevant areas and assess | Strengths and Areas for improvement |
Integrity—results are accurate and reliable and ensure confidence | |||
Segmentation—to reveal meaningful insights | |||
Trends—sustained positive performance at least 3 years | Search evidence in relevant areas and assess | Strengths and Areas for improvement | |
Targets—are set and are consistently achieved, in line with the strategic objectives | |||
Comparisons—external comparisons are made and these are favorable, in line with the strategic objectives | |||
Confidence—the performance level will be sustained as enablers—results relationship is conditioned | |||
Summary per Result subcriterion | Consolidated rating | Strengths and Areas for improvement |
Assessment framework for results.
For a better understanding of how the day-to-day activity of the organization should be framed into the excellence assessment, some guidance is presented in Table 5. Current tools, developments, and ways of working may be associated to enablers, but the management thinking design should always be mirrored by the results (perceptions and outcomes) assessment and their evolution understanding, compared with targets and adequately/dynamically benchmarked. The cause-effect relation helps in understanding the “why” behind the organization’s approach, the “how” to deploy the approaches, and the achievements as a result, in practice the consequence of all these actions.
Enabler | Subcriterion | Possible approach | Possible deployment |
---|---|---|---|
Leadership | Leaders develop the Mission, Vision, Values, Ethics and act as models | Define the core business purpose for a sustainable future and consequently the Values and Ethics | Vision, Mission, Values are developed and integrated into the Strategy and communicated regularly to all stakeholders |
Define and review leaders code of conduct/agreed behaviors to explicit the leaders role model | Enable assessment, review, improvement of individual performance, mainly those of leaders | ||
360° Appraisal - evaluate leaders performance based on feedback from all levels of interaction top, down and lateral | Deploy a sound process of assessment of the individual performance so as to build a culture of trust and ethics | ||
Leaders define, monitor, review and improve the management system and the performance | Set strategic measures to monitor performance in line with the stakeholders needs and expectations, such as Balanced Scorecard | Management team assess progression against targets set so as to achieve the strategic goals; composite indicators are regularly analyzed as part of the decision process | |
Management board meetings for regular review and refinement in line with the business | Strategic objectives are cascaded into the reporting processes (financial, operational a.s.o) | ||
Leaders engage with external stakeholders | Regular contact of senior management with key customers, partners and community representatives | Define business to business strategic level and review it regularly in line with the strategic goals | |
Reporting and public communication, such as Sustainability report (UN Global Compact) | The reports content, format and circulation concern business key financial, environmental and societal progression, in line with international initiatives committed for, if the case | ||
Leaders reinforce the culture of excellence with organization’s people | Define the culture of excellence by adopting a business model in line with an excellence model, such as EFQM | Consider excellence as a reference in the planning processes; leaders actively involve people in improvements | |
Leaders ensure that the organization is flexible and manage changes effectively | Annual Board Meeting—the Board communicate the plans and gain support/commitment for their implementation | The management team agrees the strategic plans and gain support, if the case, from shareholders | |
Annual kick-off event—leaders communicate the overall strategy and the annual objectives | Leaders adopt organization’s objectives and cascade them to individual ones in their teams | ||
Strategy | Strategy is based on understanding both stakeholders’ needs and expectations and external environment | Understanding developments, opportunities, threats on the desired and current market | Relate market analysis with strategic partners, knowledge management and research and development, connect with academics a.s.o. |
Understand any updates concerning legal and regulatory compliance | Legal and operational teams should cooperate to identify and implement the regulatory and compliance framework and correspondent actions to set in place | ||
Strategy is based on deeply understanding internal performance and capabilities | Perform an in-depth self-assessment conducted internally or externally; Cross check with control systems results | Perform an in-depth self-assessment to identify priorities for the action plans; Consider objectively the organization’s capabilities | |
Strategy and policies are developed and updated to ensure sustainability | SWOT analysis may reveal internal and external perspectives (Strengths, Weaknesses, Opportunities and Threats) | Balance internal and external perspectives in strategy, policies and strategic plans | |
Strategy and policies are communicated and deployed/documented | Strategy mapping—strategy is geographically segmented and aligned with stakeholders’ expectations | Strategy maps may be communication tools and review tools for the management team to check performance and update the objectives, plans, processes | |
Cascade objectives—align personal and teams’ objectives although the organization with the strategic ones | Start from top level and progressively break down through functional streamlines and individuals; Connect individual objectives with internal communication and the appraisal process | ||
People | People plans are aligned with the organization strategy | People engagement rather than people satisfaction | Enable people’s contribution to their full capacity to the organization goals; Link people engagement to customer loyalty and key results |
Recruiting process—attract, evaluate and select new and potential talented people | Promote mobility, link to remuneration and benefits policies, adapt to the level of people to be recruited, third part/external service may be used | ||
Succession planning—identify potential successors for the key roles and prepare them adequately | Prepare business continuity planning on immediate and long-term perspective and review regularly the planning | ||
People’s knowledge and skills are developed | Appraisal process—assess individual performance and behaviors against a set of agreed objectives, competences, attitudes | Align organization’s overall objectives to people individual performance and objectives; Link to people survey and to performance related incentives (salary, bonus, promotion…penalty) | |
Personal development and training—align individual needs to competences needed for the role as derived by the strategic objectives | HR strategy is aligned to people capabilities, organizational needs to fulfill the strategic goals and the appraisal process; Training plans are drafted and implemented, results of training are assessed and valorized | ||
Management development programs and/or people certification | Talent management plans set in place; Staff certification for roles needing it or for professionals in industry/sector setting the requirement, eventually on regular basis | ||
People are aligned, engaged and empowered | Process improvement teams—improvement as culture in a structural process | Privilege cross-functional teams; Involve (experts) facilitators or include training to guide the process | |
5S—workplace and flows organization methodology | Empowering people to improve the workplace and the processes they are involved in; Facilitate processes’ standardization | ||
Objectives’ cascade—align individuals to strategic objectives | Connect to strategic planning process (ex-ante) and the appraisal process and people motivation policies objectively supported by people performance (ex-post) | ||
People communicate effectively throughout the organization | Internal communication—clear communication channels top, down, horizontal, inter-departments/units | Ensure a bilateral way of communication to support dialog and information transfer, based on needs of people and teams; Use surveys to assess the effectiveness | |
Electronic communication media | Encourage communication and networking through e-means (intranet, blogs, social networking a.s.o.), but maintain and valorize physical interaction, too | ||
Workers council | Develop a sustainable partnership with the workers’ structures, if any | ||
People are recognized, rewarded and cared for | Rewards and benefits | Develop a flexible benefit package aligned to overall HR strategy | |
Salary benchmarking | Screen the connection between people’s motivation incentives and benefit package in the region, industry, sector etc. (external service may be used) | ||
Health and safety | Implement legal and regulatory compliance in term of occupational safety and health; Bonus as medical insurance, welfare, facilities for family | ||
Partnership and resources | Partners and suppliers are managed for sustainable benefit | Suppliers’ selection criteria | Suppliers’ audits, assessment |
Establish, develop and manage relationship with partners | Partnership-related processes clearly defined, monitored and assessed; Partners’ performance reported (impact on KPI) and related to Strategy | ||
Finances are managed to secure sustained success | Budgeting process, with data in compliance to legal regulation, stock exchange a.s.o. | Ensure budget are aligned to strategic objectives; Budget allocations are cascaded and aligned with processes and reviewed, correlated with the Results | |
Procurement processes, lengths of supply chains | Responsible purchasing is a key for CSR strategy | ||
Buildings, equipment, materials and natural resources are managed in a sustainable way | Buildings’ policy and facilities management to ensure a safe working environment with all necessary facilities for achieving the Strategy | Effective management of sites, locations, outsourced facilities Assess people satisfaction Report sustainability Review the policies | |
Environmental management system Information security management system | Consider ISO certifications (ISO 14001, 27001 a.o.) | ||
Technology is managed to support strategy | Possible IT outsourcing Internal digital transformation processes | IT maintenance, support, other services IT policies aligned to strategic goal People training and support | |
Information and knowledge are managed to build operational capability | Knowledge management system Ensure data security, availability, integrity | Build a knowledge management system Capitalize the organizations’ knowledge | |
Processes, Products and Services | Processes are designed and managed to optimize the value for stakeholders | Process approach and risk-based thinking | ISO 9001 implementation/certification |
Lean Six Sigma | DMAIC to understand performance dynamics and identify improvement options Monitor customer experience | ||
Products and services are developed to create value for customers | Research and development | Sustainability issues, production techniques, end life cycle monitored, recycling, buy-back, research on as-used components | |
Focus groups to collect and generate new ideas, direct feedback | Involve customer in testing new products Collect regularly the Voice of Customer (VOC) | ||
Products and services are effectively promoted and marketed | Strategy of marketing / product launching, including target audience, value proposition, pricing, promotion | Clear definition of target audience; Use effective channels for reaching audience Assess the marketing campaign through the effective results | |
Products and services are produced, delivered and managed | Supply chain management to ensure effective delivery of products and services to customer | Connect CSR into the supply chain management | |
Customer relationships are managed and enhanced | Customer relationship management—a system set in place tracking contacts, accompanied details of expectations | Connect to product development, marketing-sales and performance indicators | |
Customer centers | Sometimes outsourced Dependent on customer strategy adopted | ||
Customer surveys, the most common tool to collect customer experience | Frequency, segmentation, use of results to drive improvements and review of strategy |
Guidance for enablers.
Considering the evolution of the industrial fields nowadays and the requirements stated by the standards and laws, companies have adopted more often the concept of sustainability. The sustainability development of a company is given by the three pillars of sustainability (see Figure 1): society (social responsibility), economic growth, and the environment protection. The three pillars are embedded within the company’s management systems.
Sustainability pillars.
Since the first pillar of sustainability—economic growth—has been defined, this has appeared important for companies to remain in competition in their field of activity. In order to maintain a constant economic growth, companies define strategic objectives and continuously implement these objectives in all areas of improvement identified using several types of performance models. This pillar may relate to the first two enablers presented in Table 5: Leadership and Strategy.
Second and third pillars of sustainability development cover the other three enablers presented in Table 5: people, partnership and resources, and some parts of processes, products, and services.
The three pillars are, also, reflected in the Business Continuity Plan of companies, plan required by the legal norms in each country. Every company must consider and establish possible actions to keep under control the impact on the society and environment in any given situation.
In order to support companies and harmonize their social behavior, the International Organization for Standardization (ISO) has created the standard “
The standard contains voluntary guidance, but it does not need a certification. Table 6 presents an example of steps that can be followed in order to implement the standard. Before implementing the ISO 26000, the most important step is to identify the stakeholders of the company and the impact they have on the social responsibility decisions that will be taken and implemented (see Figure 2).
Steps | Possible actions | |
---|---|---|
Plan | Identify the need benefits of implementing SR standard in the company | Establish the SR characteristics |
Identify the relationship between SR and sustainability | ||
Define the policy and the strategy | Identify stakeholders | |
Identify and create a common ground between the values of the company and the SR values | ||
Analyze the SR principles | ||
Analyze and identify the needed areas for the company considering the seven core subjects of SR | ||
DO | Integrate in the existing management system the SR requirements | Adopt the SR principles |
Establish the SR objectives | ||
Establish the KPI (key performance indicators) for SR | ||
State the action plan | ||
Implement the possible actions | Establish the way of reporting the KPI | |
Raise awareness in the company | ||
Integrate the action plan in the company systems | ||
Communicate and set the reporting means for all the stakeholders | Identify the most effective way of communication | |
Engage the stakeholders taking into account their impact on the company decisions regarding SR | ||
Analyze the SR influence | ||
Report the KPI established | ||
Check | Evaluate | Monitor the SR performance |
Analyze the data obtained | ||
Act | Improve | Identify possible action in order to improve the SR performance Track the improvements impact |
Implementation of the ISO 26000 standard.
Stakeholders.
The NEN Handbook “The implementation of SR – Best practices and tools for ISO 26000” offers a set of detailed free tools that can be used to implement the Social Responsibility (SR) in companies (see Table 6).
In order to implement the SR principles and objectives in the organization management, first of all, the relevant areas of interest correlated with the core subjects of ISO 26000 should be identified. In Table 7 are presented some relevant areas that can be important for different companies.
Core subject | Relevant areas of interest | Stakeholders |
---|---|---|
Organizational Governance | The application of the SR principles ensures an elevated level of organizational governance | The organization leaders Employers |
A joint effort is needed, considering the size of the Organization, to achieve the desired results associated with SR. | ||
The most effective mechanism to implement is to maintain the motivation of the stakeholders and to proper develop of the principles of Social Responsibility | ||
Human Rights | Establish transparent and effective complaint and redress mechanisms | The organization leaders Employers Customers Suppliers Society Local government |
“Equal rights for all employees and workers (such as gender equality) Strive for diversity in the employee group” | ||
Freedom of opinion and expression | ||
Contribution to economic, social and cultural rights | ||
“No child labor and no forced labor Freedom of association or collective bargaining “ | ||
Labor Practices | Contracts for employees with clear and correct mentions | The organization leaders Employers |
Equal and equitable opportunities for all employees | ||
Contracts with clear and fair mentions to subcontractors, suppliers and partners | ||
Protection of personal and private data of employees | ||
Social protection for employees | ||
Collaboration and openness to dialog with independent representatives representing the interests of employees | ||
Continuous communication with local communities or other local stakeholders | ||
Implementation of occupational medicine systems | ||
Emergency assistance | ||
Handling/Handling of Dangerous Equipment | ||
Preventive Medical Investigations | ||
Staff development and training plan | ||
Training program for new employees | ||
Environment | Respecting and promoting the following principles:
| The organization leaders Employers Customers Suppliers Society Local government |
Pollution prevention through management:
| ||
Sustainable use of resources through the effective use of the following:
| The organization leaders Employers Society | |
Climate change mitigation through effective management of greenhouse gas emissions, Reducing vulnerability to floods | The organization leaders Society | |
Valorization and protection of biodiversity | ||
Valorization and Sustainable use of land and natural resources Restoration of ecosystems | ||
Progress on ecological urban and rural development | ||
Fair Operating Practices | Clear rules regarding the accepted level of giving and receiving business gifts Respecting the local culture | The organization leaders Employers Costumers Suppliers |
Verification of certificates and declarations of origin | ||
Establishing rules and boundaries regarding political lobbying | ||
Similar level of information available to all providers and contractors | ||
Contracts including clear terms and fair prices in relation to suppliers and | ||
Honest pricing policy with suppliers | ||
Implement appropriate vigilance mechanisms | ||
Payment of fair compensation for intellectual and physical property rights | ||
Consumer Issues | Clear, honest and complete information about the products or services delivered and their impact. | The organization leaders Customers Employers |
Mechanisms for returning and withdrawing the product from the market. | ||
Reliable, accurate, and verifiable information about the impact of products/services on the environment, society or economy | ||
Adequate and relevant information on: product health and safety, possible negative impacts, maintenance, assembly or recycling. | ||
Products that can be recycled or repaired and reused | ||
Accessible and efficient customer complaint mechanism | ||
Mechanisms for proper installation, use, repair, maintenance, return and recycling | ||
Clear and fair guarantee and implementation mechanism | ||
Mechanism for resolving disputes, resolving disputes, and mediating at a minimum cost to consumers | ||
Transparent mechanism for obtaining, using, securing, and deleting personal data | ||
The right of the customer/consumer to verify personal data | ||
Protection policy for the provision of essential services to all consumers | ||
Education and awareness program for customers/consumers regarding the purchase conditions, comparison of key functions, impact of use, etc. | ||
Community involvement and development | Analysis of communities affected by core activities | The organization leaders Society |
Review of supporting the Millennium Development Goals or local development goals | ||
Education and learning program for communities | ||
Plan for respecting cultural traditions and protecting cultural heritage | ||
Participation in local and national skills development programs, including apprenticeships | ||
Plan for the direct creation of local jobs | ||
Collaboration with universities or institutions in stimulating and providing technology at accessible local conditions | ||
Providing fair opportunities for local suppliers and SMEs | ||
Fair fiscal policy | ||
Program to support communities with essential health care services, access to clean water, good sanitation | ||
Activities to stimulate the improvement of the infrastructure for transport, water, electricity, communications, etc. |
The core subjects from ISO 26000 [10].
Companies that have implemented ISO 26000 and monitor sustainability should annually report the key performance indicators they set. In order to do that, they can use the reporting framework given by the GRI.
Analyzing the common ground of the excellence models (EFQM) or sustainability, one may notice that for both approaches the companies must:
Set objectives considering the fundamental concepts that the company has adopted and internalized in the company’s culture
Identify KPI for both and then ways and tools to monitor them
Evaluate the performance on a regular basis
Report the results
Relaunch the cycle considering the performance and results versus the targets and comparing to the competitors when resetting the objectives.
Considering a company that adopted both excellence and sustainability concepts and codefined the company’s values starting from these fundamentals, one may propose the structure of the company’s management system looking similar to the Greek temple, as presented in Figure 3.
Company structure.
The foundation to build a surviving business may embed the fundamental concepts of excellence and sustainability, the pillars for maintaining the business in the global competition should arise from the two models, merging the enablers and the results of excellence with the criteria to assess sustainability, and finally, the company assesses and reports regularly the KPI and the other metrics in order to better comply with the values, to differentiate among competitors, and to better serve the stakeholders.
This work has been funded from the Erasmus + project “Boosting Sustainable Digital Education for European Universities (BoostEdU),” no. 2020-1-CZ01-KA226-HE-094408. The European Commission has no responsibility concerning the content of this deliverable.
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Flawed sample preparations can undermine the quality of results and lead to false conclusions. Thus, the aim of this chapter is to equip researchers, post graduate students and technicians with essential knowledge required to prepare samples for scanning electron microscopy (SEM) investigations in the life sciences.",book:{id:"5075",slug:"modern-electron-microscopy-in-physical-and-life-sciences",title:"Modern Electron Microscopy in Physical and Life Sciences",fullTitle:"Modern Electron Microscopy in Physical and Life Sciences"},signatures:"Mogana Das Murtey and Patchamuthu Ramasamy",authors:[{id:"176330",title:"Dr.",name:"Mogana",middleName:"Das",surname:"Murtey",slug:"mogana-murtey",fullName:"Mogana Murtey"},{id:"181159",title:"Mr.",name:"Patchamuthu",middleName:null,surname:"Ramasamy",slug:"patchamuthu-ramasamy",fullName:"Patchamuthu Ramasamy"}]},{id:"49537",doi:"10.5772/61781",title:"Electron Diffraction",slug:"electron-diffraction",totalDownloads:10117,totalCrossrefCites:11,totalDimensionsCites:32,abstract:"Electron microscopes are usually supplied with equipment for obtaining diffraction patterns and micrographs from the same area of a specimen and the best results are attained if the complete use is to be made of these combined facilities. 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Finally, electron diffraction patterns of new materials are investigated.",book:{id:"5075",slug:"modern-electron-microscopy-in-physical-and-life-sciences",title:"Modern Electron Microscopy in Physical and Life Sciences",fullTitle:"Modern Electron Microscopy in Physical and Life Sciences"},signatures:"Mohsen Asadi Asadabad and Mohammad Jafari Eskandari",authors:[{id:"176352",title:"Dr.",name:"Mohsen",middleName:null,surname:"Asadi Asadabad",slug:"mohsen-asadi-asadabad",fullName:"Mohsen Asadi Asadabad"},{id:"177600",title:"Dr.",name:"Mohammad",middleName:null,surname:"Jafari Eskandari",slug:"mohammad-jafari-eskandari",fullName:"Mohammad Jafari Eskandari"}]},{id:"49526",doi:"10.5772/61634",title:"Focused Ion Beams (FIB) — Novel Methodologies and Recent Applications for Multidisciplinary Sciences",slug:"focused-ion-beams-fib-novel-methodologies-and-recent-applications-for-multidisciplinary-sciences",totalDownloads:4305,totalCrossrefCites:5,totalDimensionsCites:11,abstract:"Considered as the newest field of electron microscopy, focused ion beam (FIB) technologies are used in many fields of science for site-specific analysis, imaging, milling, deposition, micromachining, and manipulation. Dual-beam platforms, combining a high-resolution scanning electron microscope (HR-SEM) and an FIB column, additionally equipped with precursor-based gas injection systems (GIS), micromanipulators, and chemical analysis tools (such as energy-dispersive spectra (EDS) or wavelength-dispersive spectra (WDS)), serve as multifunctional tools for direct lithography in terms of nano-machining and nano-prototyping, while advanced specimen preparation for transmission electron microscopy (TEM) can practically be carried out with ultrahigh precision. Especially, when hard materials and material systems with hard substrates are concerned, FIB is the only technique for site-specific micro- and nanostructuring. 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The initial process of urine formations is done by the glomerular filtration barrier inside the glomeruli. This specialized barrier consists of three layers, fenestrated endothelium, basement membrane, and podocytes, which ensure that water and small molecules pass through while cells and large molecules are retained. The glomerular filtration barrier is found with abnormal morphology in several diseases and is associated with renal malfunction; thus, it is interesting to study these structures in different experimental and clinical conditions. The normal glomerular barrier and its alterations in some conditions (hypertension, diabetes, and fetal programming) are discussed in this chapter. Furthermore, some methods for studying the glomerular filtration barrier by electron microscopy, both by qualitative and quantitative methods, are present.",book:{id:"5075",slug:"modern-electron-microscopy-in-physical-and-life-sciences",title:"Modern Electron Microscopy in Physical and Life Sciences",fullTitle:"Modern Electron Microscopy in Physical and Life Sciences"},signatures:"Diogo Benchimol de Souza, Bianca Martins Gregório, Marlene\nBenchimol and Fernanda Amorim de Morais Nascimento",authors:[{id:"176343",title:"Dr.",name:"Diogo Benchimol",middleName:null,surname:"De Souza",slug:"diogo-benchimol-de-souza",fullName:"Diogo Benchimol De Souza"},{id:"176436",title:"Prof.",name:"Bianca Martins",middleName:null,surname:"Gregório",slug:"bianca-martins-gregorio",fullName:"Bianca Martins Gregório"},{id:"176437",title:"Prof.",name:"Fernanda Amorim De Morais",middleName:null,surname:"Nascimento",slug:"fernanda-amorim-de-morais-nascimento",fullName:"Fernanda Amorim De Morais Nascimento"},{id:"177637",title:"Prof.",name:"Marlene",middleName:null,surname:"Benchimol",slug:"marlene-benchimol",fullName:"Marlene Benchimol"}]},{id:"49520",doi:"10.5772/61719",title:"Immunogold Techniques in Electron Microscopy",slug:"immunogold-techniques-in-electron-microscopy",totalDownloads:4397,totalCrossrefCites:1,totalDimensionsCites:7,abstract:"Ever since electron microscopy became an important tool in the scientific research, the focus had been mainly on ultrastructural analysis with little success in the development and application of suitable techniques for the localization of macromolecules in cells. The emergence of immunogold techniques in the 1960s managed to fill this gap in serving this function. The aim of this chapter is to equip researchers, postgraduate students, and technicians with essential knowledge to utilize immunogold techniques for ultrastructural investigations in the life sciences. The principles and factors involved have been highlighted to give researchers a quick review of the techniques before embarking on their ultrastructural localization procedures. The advantages and limitations of the four types of immunogold labeling techniques have been discussed.",book:{id:"5075",slug:"modern-electron-microscopy-in-physical-and-life-sciences",title:"Modern Electron Microscopy in Physical and Life Sciences",fullTitle:"Modern Electron Microscopy in Physical and Life Sciences"},signatures:"Mogana Das Murtey",authors:[{id:"176330",title:"Dr.",name:"Mogana",middleName:"Das",surname:"Murtey",slug:"mogana-murtey",fullName:"Mogana Murtey"}]}],mostDownloadedChaptersLast30Days:[{id:"49526",title:"Focused Ion Beams (FIB) — Novel Methodologies and Recent Applications for Multidisciplinary Sciences",slug:"focused-ion-beams-fib-novel-methodologies-and-recent-applications-for-multidisciplinary-sciences",totalDownloads:4299,totalCrossrefCites:5,totalDimensionsCites:11,abstract:"Considered as the newest field of electron microscopy, focused ion beam (FIB) technologies are used in many fields of science for site-specific analysis, imaging, milling, deposition, micromachining, and manipulation. 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Moreover, FIB sectioning and sampling techniques are frequently used for revealing the structural and morphological distribution of material systems with three-dimensional (3D) network at micro-/nanoscale.This book chapter includes many examples on conventional and novel processes of FIB technologies, ranging from analysis of semiconductors to electron tomography-based imaging of hard materials such as nanoporous ceramics and composites. 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Electron diffraction patterns are used to obtain quantitative data including phase identification, orientation relationship and crystal defects in materials, etc. At first, a general introduction including a geometrical and quantitative approach to electron diffraction from a crystalline specimen, the reciprocal lattice and electron diffraction in the electron microscope are presented. The scattering process by an individual atom as well as a crystal, the Bragg law, Laue conditions and structure factor are also discussed. Types of diffraction patterns such as ring pattern, spot pattern and Kikuchi pattern, and general and unique indexing diffraction patterns are explained. The procedure for indexing simple, complicated and imperfect patterns as well as Kikuchi lines and a combination of Kikuchi lines and spots is outlined. The known and unknown materials are identified by indexing patterns. Practical comparisons between various methods of analysing diffraction patterns are also described. The basic diffraction patterns and the fine structure in the patterns including specimen tilting experiments, orientation relationship determination, phase identification, twinning, second phases, crystallographic information, dislocation, preferred orientation and texture, extra spots and streaks are described in detail. Finally, electron diffraction patterns of new materials are investigated.",book:{id:"5075",slug:"modern-electron-microscopy-in-physical-and-life-sciences",title:"Modern Electron Microscopy in Physical and Life Sciences",fullTitle:"Modern Electron Microscopy in Physical and Life Sciences"},signatures:"Mohsen Asadi Asadabad and Mohammad Jafari Eskandari",authors:[{id:"176352",title:"Dr.",name:"Mohsen",middleName:null,surname:"Asadi Asadabad",slug:"mohsen-asadi-asadabad",fullName:"Mohsen Asadi Asadabad"},{id:"177600",title:"Dr.",name:"Mohammad",middleName:null,surname:"Jafari Eskandari",slug:"mohammad-jafari-eskandari",fullName:"Mohammad Jafari Eskandari"}]},{id:"49846",title:"Scanning Electron Microscopy with a Retarded Primary Beam",slug:"scanning-electron-microscopy-with-a-retarded-primary-beam",totalDownloads:2026,totalCrossrefCites:1,totalDimensionsCites:2,abstract:"The general trend for reducing the energies of primary electrons in electron microscopy has been faced with a gradual deterioration of the image resolution. Biasing the sample to a high negative voltage and making the electrons arbitrarily slow solely on and inside the sample has shown itself to be far more feasible than originally expected. The fundamental aberration coefficients (spherical and chromatic) of a combination of an objective lens and an immersion electrostatic lens formed by the biased sample decrease with the decreasing landing energy of the electrons. As a result, the spot size in scanning systems may become nearly independent of the landing energy of the electrons. The requirements placed on samples are strict but feasible, and detection of signal electrons is greatly facilitated by the acceleration of both reflected and transmitted electrons in the field of the biased sample and their collimation toward the optical axis. The interaction of slow electrons is not only more intensive than that at standard energies but even scattering phenomena appear which are not otherwise observed. Several application examples are presented. 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Several microscopic techniques, namely light, scanning and transmission electron microscopy, electron backscatter diffraction, and automated crystallographic orientation mapping were employed to characterize the details of microstructure evolution and grain fragmentation of the alloy as a function of strain imposed to the material using these SPD techniques. The advantages and drawbacks of these techniques, as well as the limits of their resolution, are discussed in detail. The results of microstructure observations indicate the effectiveness of grain refinement by severe plastic deformation in this alloy. 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Heshmati",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/313921/images/system/313921.jpg",biography:"Dr. Hassan Massoud Heshmati is an endocrinologist with 46 years of experience in clinical research in academia (university-affiliated hospitals, Paris, France; Mayo Foundation, Rochester, MN, USA) and pharmaceutical companies (Sanofi, Malvern, PA, USA; Essentialis, Carlsbad, CA, USA; Gelesis, Boston, MA, USA). His research activity focuses on pituitary tumors, hyperthyroidism, thyroid cancers, osteoporosis, diabetes, and obesity. He has extensive knowledge in the development of anti-obesity products. Dr. Heshmati is the author of 299 abstracts, chapters, and articles related to endocrinology and metabolism. He is currently a consultant at Endocrinology Metabolism Consulting, LLC, Anthem, AZ, USA.",institutionString:"Endocrinology Metabolism Consulting, LLC",institution:null},{id:"76477",title:"Prof.",name:"Mirza",middleName:null,surname:"Hasanuzzaman",slug:"mirza-hasanuzzaman",fullName:"Mirza Hasanuzzaman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/76477/images/system/76477.png",biography:"Dr. Mirza Hasanuzzaman is a Professor of Agronomy at Sher-e-Bangla Agricultural University, Bangladesh. He received his Ph.D. in Plant Stress Physiology and Antioxidant Metabolism from Ehime University, Japan, with a scholarship from the Japanese Government (MEXT). Later, he completed his postdoctoral research at the Center of Molecular Biosciences, University of the Ryukyus, Japan, as a recipient of the Japan Society for the Promotion of Science (JSPS) postdoctoral fellowship. He was also the recipient of the Australian Government Endeavour Research Fellowship for postdoctoral research as an adjunct senior researcher at the University of Tasmania, Australia. Dr. Hasanuzzaman’s current work is focused on the physiological and molecular mechanisms of environmental stress tolerance. Dr. Hasanuzzaman has published more than 150 articles in peer-reviewed journals. He has edited ten books and written more than forty book chapters on important aspects of plant physiology, plant stress tolerance, and crop production. According to Scopus, Dr. Hasanuzzaman’s publications have received more than 10,500 citations with an h-index of 53. He has been named a Highly Cited Researcher by Clarivate. He is an editor and reviewer for more than fifty peer-reviewed international journals and was a recipient of the “Publons Peer Review Award” in 2017, 2018, and 2019. He has been honored by different authorities for his outstanding performance in various fields like research and education, and he has received the World Academy of Science Young Scientist Award (2014) and the University Grants Commission (UGC) Award 2018. He is a fellow of the Bangladesh Academy of Sciences (BAS) and the Royal Society of Biology.",institutionString:"Sher-e-Bangla Agricultural University",institution:{name:"Sher-e-Bangla Agricultural University",country:{name:"Bangladesh"}}},{id:"187859",title:"Prof.",name:"Kusal",middleName:"K.",surname:"Das",slug:"kusal-das",fullName:"Kusal Das",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSBDeQAO/Profile_Picture_1623411145568",biography:"Kusal K. Das is a Distinguished Chair Professor of Physiology, Shri B. M. Patil Medical College and Director, Centre for Advanced Medical Research (CAMR), BLDE (Deemed to be University), Vijayapur, Karnataka, India. Dr. Das did his M.S. and Ph.D. in Human Physiology from the University of Calcutta, Kolkata. His area of research is focused on understanding of molecular mechanisms of heavy metal activated low oxygen sensing pathways in vascular pathophysiology. He has invented a new method of estimation of serum vitamin E. His expertise in critical experimental protocols on vascular functions in experimental animals was well documented by his quality of publications. He was a Visiting Professor of Medicine at University of Leeds, United Kingdom (2014-2016) and Tulane University, New Orleans, USA (2017). For his immense contribution in medical research Ministry of Science and Technology, Government of India conferred him 'G.P. Chatterjee Memorial Research Prize-2019” and he is also the recipient of 'Dr.Raja Ramanna State Scientist Award 2015” by Government of Karnataka. He is a Fellow of the Royal Society of Biology (FRSB), London and Honorary Fellow of Karnataka Science and Technology Academy, Department of Science and Technology, Government of Karnataka.",institutionString:"BLDE (Deemed to be University), India",institution:null},{id:"243660",title:"Dr.",name:"Mallanagouda Shivanagouda",middleName:null,surname:"Biradar",slug:"mallanagouda-shivanagouda-biradar",fullName:"Mallanagouda Shivanagouda Biradar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243660/images/system/243660.jpeg",biography:"M. S. Biradar is Vice Chancellor and Professor of Medicine of\nBLDE (Deemed to be University), Vijayapura, Karnataka, India.\nHe obtained his MD with a gold medal in General Medicine and\nhas devoted himself to medical teaching, research, and administrations. He has also immensely contributed to medical research\non vascular medicine, which is reflected by his numerous publications including books and book chapters. Professor Biradar was\nalso Visiting Professor at Tulane University School of Medicine, New Orleans, USA.",institutionString:"BLDE (Deemed to be University)",institution:{name:"BLDE University",country:{name:"India"}}},{id:"289796",title:"Dr.",name:"Swastika",middleName:null,surname:"Das",slug:"swastika-das",fullName:"Swastika Das",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/289796/images/system/289796.jpeg",biography:"Swastika N. Das is Professor of Chemistry at the V. P. Dr. P. G.\nHalakatti College of Engineering and Technology, BLDE (Deemed\nto be University), Vijayapura, Karnataka, India. She obtained an\nMSc, MPhil, and PhD in Chemistry from Sambalpur University,\nOdisha, India. Her areas of research interest are medicinal chemistry, chemical kinetics, and free radical chemistry. She is a member\nof the investigators who invented a new modified method of estimation of serum vitamin E. She has authored numerous publications including book\nchapters and is a mentor of doctoral curriculum at her university.",institutionString:"BLDEA’s V.P.Dr.P.G.Halakatti College of Engineering & Technology",institution:{name:"BLDE University",country:{name:"India"}}},{id:"248459",title:"Dr.",name:"Akikazu",middleName:null,surname:"Takada",slug:"akikazu-takada",fullName:"Akikazu Takada",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248459/images/system/248459.png",biography:"Akikazu Takada was born in Japan, 1935. After graduation from\nKeio University School of Medicine and finishing his post-graduate studies, he worked at Roswell Park Memorial Institute NY,\nUSA. He then took a professorship at Hamamatsu University\nSchool of Medicine. In thrombosis studies, he found the SK\npotentiator that enhances plasminogen activation by streptokinase. He is very much interested in simultaneous measurements\nof fatty acids, amino acids, and tryptophan degradation products. By using fatty\nacid analyses, he indicated that plasma levels of trans-fatty acids of old men were\nfar higher in the US than Japanese men. . He also showed that eicosapentaenoic acid\n(EPA) and docosahexaenoic acid (DHA) levels are higher, and arachidonic acid\nlevels are lower in Japanese than US people. By using simultaneous LC/MS analyses\nof plasma levels of tryptophan metabolites, he recently found that plasma levels of\nserotonin, kynurenine, or 5-HIAA were higher in patients of mono- and bipolar\ndepression, which are significantly different from observations reported before. In\nview of recent reports that plasma tryptophan metabolites are mainly produced by\nmicrobiota. He is now working on the relationships between microbiota and depression or autism.",institutionString:"Hamamatsu University School of Medicine",institution:{name:"Hamamatsu University School of Medicine",country:{name:"Japan"}}},{id:"137240",title:"Prof.",name:"Mohammed",middleName:null,surname:"Khalid",slug:"mohammed-khalid",fullName:"Mohammed Khalid",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/137240/images/system/137240.png",biography:"Mohammed Khalid received his B.S. in Chemistry in July 2000, and his Ph.D. in Physical Chemistry in 2007 from the University of Khartoum, Sudan. In 2009 he joined the Dr. Ron Clarke research group at the School of Chemistry, Faculty of Science, University of Sydney, Australia as a postdoctoral fellow where he worked on the Interaction of ATP with the phosphoenzyme of the Na+, K+-ATPase, and Dual mechanisms of allosteric acceleration of the Na+, K+-ATPase by ATP. He then worked as Assistant Professor at the Department of Chemistry, University of Khartoum, and in 2014 was promoted to Associate Professor ranking. In 2011 he joined the staff of the Chemistry Department at Taif University, Saudi Arabia, where he is currently active as an Assistant Professor. His research interests include:\r\n(1) P-type ATPase Enzyme Kinetics and Mechanisms; (2) Kinetics and Mechanism of Redox Reactions; (3) Autocatalytic reactions; (4) Computational enzyme kinetics; (5) Allosteric acceleration of P-type ATPases by ATP; (6) Exploring of allosteric sites of ATPases and interaction of ATP with ATPases located in the cell membranes.",institutionString:"Taif University",institution:{name:"Taif University",country:{name:"Saudi Arabia"}}},{id:"63810",title:"Prof.",name:"Jorge",middleName:null,surname:"Morales-Montor",slug:"jorge-morales-montor",fullName:"Jorge Morales-Montor",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/63810/images/system/63810.png",biography:"Dr. Jorge Morales-Montor was recognized with the Lola and Igo Flisser PUIS Award for best graduate thesis at the national level in the field of parasitology. He received a fellowship from the Fogarty Foundation to perform postdoctoral research stay at the University of Georgia. He has 153 journal articles to his credit. He has also edited several books and published more than fifty-five book chapters. He is a member of the Mexican Academy of Sciences, Latin American Academy of Sciences, and the National Academy of Medicine. He has received more than thirty-five awards and has supervised numerous bachelor’s, master’s, and Ph.D. students. Dr. Morales-Montor is the past president of the Mexican Society of Parasitology.",institutionString:"National Autonomous University of Mexico",institution:{name:"National Autonomous University of Mexico",country:{name:"Mexico"}}},{id:"217215",title:"Dr.",name:"Palash",middleName:null,surname:"Mandal",slug:"palash-mandal",fullName:"Palash Mandal",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/217215/images/system/217215.jpeg",biography:null,institutionString:"Charusat University",institution:null},{id:"49739",title:"Dr.",name:"Leszek",middleName:null,surname:"Szablewski",slug:"leszek-szablewski",fullName:"Leszek Szablewski",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49739/images/system/49739.jpg",biography:"Leszek Szablewski is a professor of medical sciences. He received his M.S. in the Faculty of Biology from the University of Warsaw and his PhD degree from the Institute of Experimental Biology Polish Academy of Sciences. He habilitated in the Medical University of Warsaw, and he obtained his degree of Professor from the President of Poland. Professor Szablewski is the Head of Chair and Department of General Biology and Parasitology, Medical University of Warsaw. Professor Szablewski has published over 80 peer-reviewed papers in journals such as Journal of Alzheimer’s Disease, Biochim. Biophys. Acta Reviews of Cancer, Biol. Chem., J. Biomed. Sci., and Diabetes/Metabol. Res. Rev, Endocrine. He is the author of two books and four book chapters. He has edited four books, written 15 scripts for students, is the ad hoc reviewer of over 30 peer-reviewed journals, and editorial member of peer-reviewed journals. Prof. Szablewski’s research focuses on cell physiology, genetics, and pathophysiology. He works on the damage caused by lack of glucose homeostasis and changes in the expression and/or function of glucose transporters due to various diseases. He has given lectures, seminars, and exercises for students at the Medical University.",institutionString:"Medical University of Warsaw",institution:{name:"Medical University of Warsaw",country:{name:"Poland"}}},{id:"173123",title:"Dr.",name:"Maitham",middleName:null,surname:"Khajah",slug:"maitham-khajah",fullName:"Maitham Khajah",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/173123/images/system/173123.jpeg",biography:"Dr. Maitham A. Khajah received his degree in Pharmacy from Faculty of Pharmacy, Kuwait University, in 2003 and obtained his PhD degree in December 2009 from the University of Calgary, Canada (Gastrointestinal Science and Immunology). Since January 2010 he has been assistant professor in Kuwait University, Faculty of Pharmacy, Department of Pharmacology and Therapeutics. His research interest are molecular targets for the treatment of inflammatory bowel disease (IBD) and the mechanisms responsible for immune cell chemotaxis. He cosupervised many students for the MSc Molecular Biology Program, College of Graduate Studies, Kuwait University. Ever since joining Kuwait University in 2010, he got various grants as PI and Co-I. He was awarded the Best Young Researcher Award by Kuwait University, Research Sector, for the Year 2013–2014. He was a member in the organizing committee for three conferences organized by Kuwait University, Faculty of Pharmacy, as cochair and a member in the scientific committee (the 3rd, 4th, and 5th Kuwait International Pharmacy Conference).",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"195136",title:"Dr.",name:"Aya",middleName:null,surname:"Adel",slug:"aya-adel",fullName:"Aya Adel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/195136/images/system/195136.jpg",biography:"Dr. Adel works as an Assistant Lecturer in the unit of Phoniatrics, Department of Otolaryngology, Ain Shams University in Cairo, Egypt. Dr. Adel is especially interested in joint attention and its impairment in autism spectrum disorder",institutionString:"Ain Shams University",institution:{name:"Ain Shams University",country:{name:"Egypt"}}},{id:"94911",title:"Dr.",name:"Boulenouar",middleName:null,surname:"Mesraoua",slug:"boulenouar-mesraoua",fullName:"Boulenouar Mesraoua",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94911/images/system/94911.png",biography:"Dr Boulenouar Mesraoua is the Associate Professor of Clinical Neurology at Weill Cornell Medical College-Qatar and a Consultant Neurologist at Hamad Medical Corporation at the Neuroscience Department; He graduated as a Medical Doctor from the University of Oran, Algeria; he then moved to Belgium, the City of Liege, for a Residency in Internal Medicine and Neurology at Liege University; after getting the Belgian Board of Neurology (with high marks), he went to the National Hospital for Nervous Diseases, Queen Square, London, United Kingdom for a fellowship in Clinical Neurophysiology, under Pr Willison ; Dr Mesraoua had also further training in Epilepsy and Continuous EEG Monitoring for two years (from 2001-2003) in the Neurophysiology department of Zurich University, Switzerland, under late Pr Hans Gregor Wieser ,an internationally known epileptologist expert. \n\nDr B. Mesraoua is the Director of the Neurology Fellowship Program at the Neurology Section and an active member of the newly created Comprehensive Epilepsy Program at Hamad General Hospital, Doha, Qatar; he is also Assistant Director of the Residency Program at the Qatar Medical School. \nDr B. Mesraoua's main interests are Epilepsy, Multiple Sclerosis, and Clinical Neurology; He is the Chairman and the Organizer of the well known Qatar Epilepsy Symposium, he is running yearly for the past 14 years and which is considered a landmark in the Gulf region; He has also started last year , together with other epileptologists from Qatar, the region and elsewhere, a yearly International Epilepsy School Course, which was attended by many neurologists from the Area.\n\nInternationally, Dr Mesraoua is an active and elected member of the Commission on Eastern Mediterranean Region (EMR ) , a regional branch of the International League Against Epilepsy (ILAE), where he represents the Middle East and North Africa(MENA ) and where he holds the position of chief of the Epilepsy Epidemiology Section; Dr Mesraoua is a member of the American Academy of Neurology, the Europeen Academy of Neurology and the American Epilepsy Society.\n\nDr Mesraoua's main objectives are to encourage frequent gathering of the epileptologists/neurologists from the MENA region and the rest of the world, promote Epilepsy Teaching in the MENA Region, and encourage multicenter studies involving neurologists and epileptologists in the MENA region, particularly epilepsy epidemiological studies. \n\nDr. Mesraoua is the recipient of two research Grants, as the Lead Principal Investigator (750.000 USD and 250.000 USD) from the Qatar National Research Fund (QNRF) and the Hamad Hospital Internal Research Grant (IRGC), on the following topics : “Continuous EEG Monitoring in the ICU “ and on “Alpha-lactoalbumin , proof of concept in the treatment of epilepsy” .Dr Mesraoua is a reviewer for the journal \"seizures\" (Europeen Epilepsy Journal ) as well as dove journals ; Dr Mesraoua is the author and co-author of many peer reviewed publications and four book chapters in the field of Epilepsy and Clinical Neurology",institutionString:"Weill Cornell Medical College in Qatar",institution:{name:"Weill Cornell Medical College in Qatar",country:{name:"Qatar"}}},{id:"282429",title:"Prof.",name:"Covanis",middleName:null,surname:"Athanasios",slug:"covanis-athanasios",fullName:"Covanis Athanasios",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/282429/images/system/282429.jpg",biography:null,institutionString:"Neurology-Neurophysiology Department of the Children Hospital Agia Sophia",institution:null},{id:"190980",title:"Prof.",name:"Marwa",middleName:null,surname:"Mahmoud Saleh",slug:"marwa-mahmoud-saleh",fullName:"Marwa Mahmoud Saleh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/190980/images/system/190980.jpg",biography:"Professor Marwa Mahmoud Saleh is a doctor of medicine and currently works in the unit of Phoniatrics, Department of Otolaryngology, Ain Shams University in Cairo, Egypt. She got her doctoral degree in 1991 and her doctoral thesis was accomplished in the University of Iowa, United States. Her publications covered a multitude of topics as videokymography, cochlear implants, stuttering, and dysphagia. She has lectured Egyptian phonology for many years. Her recent research interest is joint attention in autism.",institutionString:"Ain Shams University",institution:{name:"Ain Shams University",country:{name:"Egypt"}}},{id:"259190",title:"Dr.",name:"Syed Ali Raza",middleName:null,surname:"Naqvi",slug:"syed-ali-raza-naqvi",fullName:"Syed Ali Raza Naqvi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259190/images/system/259190.png",biography:"Dr. Naqvi is a radioanalytical chemist and is working as an associate professor of analytical chemistry in the Department of Chemistry, Government College University, Faisalabad, Pakistan. Advance separation techniques, nuclear analytical techniques and radiopharmaceutical analysis are the main courses that he is teaching to graduate and post-graduate students. In the research area, he is focusing on the development of organic- and biomolecule-based radiopharmaceuticals for diagnosis and therapy of infectious and cancerous diseases. Under the supervision of Dr. Naqvi, three students have completed their Ph.D. degrees and 41 students have completed their MS degrees. He has completed three research projects and is currently working on 2 projects entitled “Radiolabeling of fluoroquinolone derivatives for the diagnosis of deep-seated bacterial infections” and “Radiolabeled minigastrin peptides for diagnosis and therapy of NETs”. He has published about 100 research articles in international reputed journals and 7 book chapters. Pakistan Institute of Nuclear Science & Technology (PINSTECH) Islamabad, Punjab Institute of Nuclear Medicine (PINM), Faisalabad and Institute of Nuclear Medicine and Radiology (INOR) Abbottabad are the main collaborating institutes.",institutionString:"Government College University",institution:{name:"Government College University, Faisalabad",country:{name:"Pakistan"}}},{id:"58390",title:"Dr.",name:"Gyula",middleName:null,surname:"Mozsik",slug:"gyula-mozsik",fullName:"Gyula Mozsik",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/58390/images/system/58390.png",biography:"Gyula Mózsik MD, Ph.D., ScD (med), is an emeritus professor of Medicine at the First Department of Medicine, Univesity of Pécs, Hungary. He was head of this department from 1993 to 2003. His specializations are medicine, gastroenterology, clinical pharmacology, clinical nutrition, and dietetics. His research fields are biochemical pharmacological examinations in the human gastrointestinal (GI) mucosa, mechanisms of retinoids, drugs, capsaicin-sensitive afferent nerves, and innovative pharmacological, pharmaceutical, and nutritional (dietary) research in humans. He has published about 360 peer-reviewed papers, 197 book chapters, 692 abstracts, 19 monographs, and has edited 37 books. He has given about 1120 regular and review lectures. He has organized thirty-eight national and international congresses and symposia. He is the founder of the International Conference on Ulcer Research (ICUR); International Union of Pharmacology, Gastrointestinal Section (IUPHAR-GI); Brain-Gut Society symposiums, and gastrointestinal cytoprotective symposiums. He received the Andre Robert Award from IUPHAR-GI in 2014. Fifteen of his students have been appointed as full professors in Egypt, Cuba, and Hungary.",institutionString:"University of Pécs",institution:{name:"University of Pecs",country:{name:"Hungary"}}},{id:"277367",title:"M.Sc.",name:"Daniel",middleName:"Martin",surname:"Márquez López",slug:"daniel-marquez-lopez",fullName:"Daniel Márquez López",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/277367/images/7909_n.jpg",biography:"Msc Daniel Martin Márquez López has a bachelor degree in Industrial Chemical Engineering, a Master of science degree in the same área and he is a PhD candidate for the Instituto Politécnico Nacional. His Works are realted to the Green chemistry field, biolubricants, biodiesel, transesterification reactions for biodiesel production and the manipulation of oils for therapeutic purposes.",institutionString:null,institution:{name:"Instituto Politécnico Nacional",country:{name:"Mexico"}}},{id:"196544",title:"Prof.",name:"Angel",middleName:null,surname:"Catala",slug:"angel-catala",fullName:"Angel Catala",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/196544/images/system/196544.jpg",biography:"Angel Catalá studied chemistry at Universidad Nacional de La Plata, Argentina, where he received a Ph.D. in Chemistry (Biological Branch) in 1965. From 1964 to 1974, he worked as an Assistant in Biochemistry at the School of Medicine at the same university. From 1974 to 1976, he was a fellow of the National Institutes of Health (NIH) at the University of Connecticut, Health Center, USA. From 1985 to 2004, he served as a Full Professor of Biochemistry at the Universidad Nacional de La Plata. He is a member of the National Research Council (CONICET), Argentina, and the Argentine Society for Biochemistry and Molecular Biology (SAIB). His laboratory has been interested for many years in the lipid peroxidation of biological membranes from various tissues and different species. Dr. Catalá has directed twelve doctoral theses, published more than 100 papers in peer-reviewed journals, several chapters in books, and edited twelve books. He received awards at the 40th International Conference Biochemistry of Lipids 1999 in Dijon, France. He is the winner of the Bimbo Pan-American Nutrition, Food Science and Technology Award 2006 and 2012, South America, Human Nutrition, Professional Category. In 2006, he won the Bernardo Houssay award in pharmacology, in recognition of his meritorious works of research. Dr. Catalá belongs to the editorial board of several journals including Journal of Lipids; International Review of Biophysical Chemistry; Frontiers in Membrane Physiology and Biophysics; World Journal of Experimental Medicine and Biochemistry Research International; World Journal of Biological Chemistry, Diabetes, and the Pancreas; International Journal of Chronic Diseases & Therapy; and International Journal of Nutrition. He is the co-editor of The Open Biology Journal and associate editor for Oxidative Medicine and Cellular Longevity.",institutionString:"Universidad Nacional de La Plata",institution:{name:"National University of La Plata",country:{name:"Argentina"}}},{id:"186585",title:"Dr.",name:"Francisco Javier",middleName:null,surname:"Martin-Romero",slug:"francisco-javier-martin-romero",fullName:"Francisco Javier Martin-Romero",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSB3HQAW/Profile_Picture_1631258137641",biography:"Francisco Javier Martín-Romero (Javier) is a Professor of Biochemistry and Molecular Biology at the University of Extremadura, Spain. He is also a group leader at the Biomarkers Institute of Molecular Pathology. Javier received his Ph.D. in 1998 in Biochemistry and Biophysics. At the National Cancer Institute (National Institute of Health, Bethesda, MD) he worked as a research associate on the molecular biology of selenium and its role in health and disease. After postdoctoral collaborations with Carlos Gutierrez-Merino (University of Extremadura, Spain) and Dario Alessi (University of Dundee, UK), he established his own laboratory in 2008. The interest of Javier's lab is the study of cell signaling with a special focus on Ca2+ signaling, and how Ca2+ transport modulates the cytoskeleton, migration, differentiation, cell death, etc. He is especially interested in the study of Ca2+ channels, and the role of STIM1 in the initiation of pathological events.",institutionString:null,institution:{name:"University of Extremadura",country:{name:"Spain"}}},{id:"198499",title:"Dr.",name:"Daniel",middleName:null,surname:"Glossman-Mitnik",slug:"daniel-glossman-mitnik",fullName:"Daniel Glossman-Mitnik",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/198499/images/system/198499.jpeg",biography:"Dr. Daniel Glossman-Mitnik is currently a Titular Researcher at the Centro de Investigación en Materiales Avanzados (CIMAV), Chihuahua, Mexico, as well as a National Researcher of Level III at the Consejo Nacional de Ciencia y Tecnología, México. His research interest focuses on computational chemistry and molecular modeling of diverse systems of pharmacological, food, and alternative energy interests by resorting to DFT and Conceptual DFT. He has authored a coauthored more than 270 peer-reviewed papers, 32 book chapters, and 4 edited books. He has delivered speeches at many international and domestic conferences. He serves as a reviewer for more than eighty international journals, books, and research proposals as well as an editor for special issues of renowned scientific journals.",institutionString:null,institution:null},{id:"217323",title:"Prof.",name:"Guang-Jer",middleName:null,surname:"Wu",slug:"guang-jer-wu",fullName:"Guang-Jer Wu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/217323/images/8027_n.jpg",biography:null,institutionString:null,institution:null},{id:"148546",title:"Dr.",name:"Norma Francenia",middleName:null,surname:"Santos-Sánchez",slug:"norma-francenia-santos-sanchez",fullName:"Norma Francenia Santos-Sánchez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/148546/images/4640_n.jpg",biography:null,institutionString:null,institution:null},{id:"272889",title:"Dr.",name:"Narendra",middleName:null,surname:"Maddu",slug:"narendra-maddu",fullName:"Narendra Maddu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/272889/images/10758_n.jpg",biography:null,institutionString:null,institution:null},{id:"242491",title:"Prof.",name:"Angelica",middleName:null,surname:"Rueda",slug:"angelica-rueda",fullName:"Angelica Rueda",position:"Investigador Cinvestav 3B",profilePictureURL:"https://mts.intechopen.com/storage/users/242491/images/6765_n.jpg",biography:null,institutionString:null,institution:null},{id:"88631",title:"Dr.",name:"Ivan",middleName:null,surname:"Petyaev",slug:"ivan-petyaev",fullName:"Ivan Petyaev",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Lycotec (United Kingdom)",country:{name:"United Kingdom"}}},{id:"428313",title:"Dr.",name:"Sambangi",middleName:null,surname:"Pratyusha",slug:"sambangi-pratyusha",fullName:"Sambangi Pratyusha",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"CGIAR",country:{name:"France"}}},{id:"423869",title:"Ms.",name:"Smita",middleName:null,surname:"Rai",slug:"smita-rai",fullName:"Smita Rai",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Integral University",country:{name:"India"}}},{id:"424024",title:"Prof.",name:"Swati",middleName:null,surname:"Sharma",slug:"swati-sharma",fullName:"Swati Sharma",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Integral University",country:{name:"India"}}},{id:"439112",title:"MSc.",name:"Touseef",middleName:null,surname:"Fatima",slug:"touseef-fatima",fullName:"Touseef Fatima",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Integral University",country:{name:"India"}}}]}},subseries:{item:{id:"15",type:"subseries",title:"Chemical Biology",keywords:"Phenolic Compounds, Essential Oils, Modification of Biomolecules, Glycobiology, Combinatorial Chemistry, Therapeutic peptides, Enzyme Inhibitors",scope:"Chemical biology spans the fields of chemistry and biology involving the application of biological and chemical molecules and techniques. In recent years, the application of chemistry to biological molecules has gained significant interest in medicinal and pharmacological studies. This topic will be devoted to understanding the interplay between biomolecules and chemical compounds, their structure and function, and their potential applications in related fields. Being a part of the biochemistry discipline, the ideas and concepts that have emerged from Chemical Biology have affected other related areas. 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Dr. Beydemir has published over a hundred scientific papers spanning protein biochemistry, enzymology and medicinal chemistry, reviews, book chapters and presented several conferences to scientists worldwide. He has received numerous publication awards from various international scientific councils. He serves in the Editorial Board of several international journals. Dr. Beydemir is also Rector of Bilecik Şeyh Edebali University, Turkey.",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",slug:"deniz-ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",biography:"Dr. Deniz Ekinci obtained a BSc in Chemistry in 2004, MSc in Biochemistry in 2006, and PhD in Biochemistry in 2009 from Atatürk University, Turkey. He studied at Stetson University, USA, in 2007-2008 and at the Max Planck Institute of Molecular Cell Biology and Genetics, Germany, in 2009-2010. Dr. Ekinci currently works as a Full Professor of Biochemistry in the Faculty of Agriculture and is the Head of the Enzyme and Microbial Biotechnology Division, Ondokuz Mayıs University, Turkey. He is a member of the Turkish Biochemical Society, American Chemical Society, and German Genetics society. Dr. Ekinci published around ninety scientific papers, reviews and book chapters, and presented several conferences to scientists. He has received numerous publication awards from several scientific councils. 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