Summary of packet delivery ratio.
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Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\\n\\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\\n"}]',published:!0,mainMedia:{caption:"Highly Cited",originalUrl:"/media/original/117"}},components:[{type:"htmlEditorComponent",content:'IntechOpen is proud to announce that 191 of our authors have made the Clarivate™ Highly Cited Researchers List for 2020, ranking them among the top 1% most-cited.
\n\nThroughout the years, the list has named a total of 261 IntechOpen authors as Highly Cited. Of those researchers, 69 have been featured on the list multiple times.
\n\n\n\nReleased this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\n\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"5362",leadTitle:null,fullTitle:"Toxicology - New Aspects to This Scientific Conundrum",title:"Toxicology",subtitle:"New Aspects to This Scientific Conundrum",reviewType:"peer-reviewed",abstract:"This edited book, Toxicology - New Aspects to This Scientific Conundrum, is intended to provide an overview on the different xenobiotics employed every day in our anthropogenic activities. We hope that this book will continue to meet the expectations and needs of all interested in the implications for the living species of known and new toxicants and to guide them in the future investigations.",isbn:"978-953-51-2717-8",printIsbn:"978-953-51-2716-1",pdfIsbn:"978-953-51-7319-9",doi:"10.5772/62600",price:119,priceEur:129,priceUsd:155,slug:"toxicology-new-aspects-to-this-scientific-conundrum",numberOfPages:218,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"2061f273c8b3134dffbcb5256969ecab",bookSignature:"Sonia Soloneski and Marcelo L. Larramendy",publishedDate:"October 26th 2016",coverURL:"https://cdn.intechopen.com/books/images_new/5362.jpg",numberOfDownloads:29740,numberOfWosCitations:88,numberOfCrossrefCitations:73,numberOfCrossrefCitationsByBook:4,numberOfDimensionsCitations:169,numberOfDimensionsCitationsByBook:4,hasAltmetrics:1,numberOfTotalCitations:330,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"March 2nd 2016",dateEndSecondStepPublish:"March 23rd 2016",dateEndThirdStepPublish:"June 27th 2016",dateEndFourthStepPublish:"September 25th 2016",dateEndFifthStepPublish:"October 25th 2016",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"14764",title:"Dr.",name:"Marcelo L.",middleName:null,surname:"Larramendy",slug:"marcelo-l.-larramendy",fullName:"Marcelo L. Larramendy",profilePictureURL:"https://mts.intechopen.com/storage/users/14764/images/system/14764.jpg",biography:"Marcelo L. Larramendy, Ph.D., serves as Professor of Molecular Cell Biology at the School of Natural Sciences and Museum (National University of La Plata, Argentina). Appointed Senior Researcher of the National Scientific and Technological Research Council of Argentina. Former Member of the Executive Committee of the Latin American Association of Environmental Mutagenesis, Teratogenesis and Carcinogenesis. Author of more than 450 contributions, including scientific publications, research communications and conferences worldwide. Recipient of several national and international awards. Prof. Larramendy is a regular Lecturer at the international A. Hollaender Courses organized by the IAEMS and former guest scientist at NIH (USA) and the University of Helsinki, (Finland). He is an expert in Genetic Toxicology and is, or has been, referee for more than 20 international scientific journals. Member of the International Panel of Experts at the International Agency for Research on Cancer (IARC, WHO, Lyon, France) in 2015 for the evaluation of DDT, 2,4-D and Lindane. Presently, Prof. Dr. Larramendy is Head of the Laboratory of Molecular Cytogenetics and Genotoxicology at the UNLP.",institutionString:"National University of La Plata",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"3",totalChapterViews:"0",totalEditedBooks:"20",institution:{name:"National University of La Plata",institutionURL:null,country:{name:"Argentina"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:{id:"14863",title:"Dr.",name:"Sonia",middleName:null,surname:"Soloneski",slug:"sonia-soloneski",fullName:"Sonia Soloneski",profilePictureURL:"https://mts.intechopen.com/storage/users/14863/images/system/14863.jpg",biography:"Sonia Soloneski has a Ph.D. in Natural Sciences and is Assistant Professor of Molecular Cell Biology at the School of Natural Sciences and Museum of La Plata, National University of La Plata, Argentina. She is a member of the National Scientific and Technological Research Council (CONICET) of Argentina in the Genetic Toxicology field, the Latin American Association of Environmental Mutagenesis, Teratogenesis and Carcinogenesis (ALAMCTA), the Argentinean Society of Toxicology (ATA), the Argentinean Society of Biology (SAB) and the Society of Environmental Toxicology and Chemistry (SETAC). She has authored more than 380 contributions in the field, including scientific publications in peer-reviewed journals and research communications. She has served as a review member for more than 30 scientific international journals. She has been a plenary speaker in scientific conferences and a member of scientific committees. She is a specialist in issues related to Genetic Toxicology, Mutagenesis, and Ecotoxicology.",institutionString:"National University of La Plata",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"3",totalChapterViews:"0",totalEditedBooks:"7",institution:{name:"National University of La Plata",institutionURL:null,country:{name:"Argentina"}}},coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"1205",title:"Ecotoxicology",slug:"pharmacology-toxicology-and-pharmaceutical-science-toxicology-ecotoxicology"}],chapters:[{id:"51626",title:"Drug-Induced Cutaneous Toxicity",doi:"10.5772/64473",slug:"drug-induced-cutaneous-toxicity",totalDownloads:2560,totalCrossrefCites:2,totalDimensionsCites:2,hasAltmetrics:0,abstract:"The skin is the largest organ in the body and is continually exposed to external stimuli, such as chemical and environmental substances. Cutaneous toxicity can be broadly classified according to the mechanism of onset, namely: contact dermatitis, i.e., damage resulting from contact with a substance (irritant dermatitis, allergic contact dermatitis, chemical burns); photosensitivity, i.e., caused by combined effects of a substance and ultraviolet light (phototoxic dermatitis, photoallergic contact dermatitis); contact urticaria; chemical-induced acne; pigmentary disturbance; drug rash; hair disturbance; nail disturbance; or tumor-induced. This review outlines the function and structure of the skin, outlining characteristics of these types of cutaneous toxicity. In recent years, advances have been made in the development of pharmaceutical products targeting specific molecules or genes and nanotechnology-based pharmaceutical products, raising concerns about the onset of toxicity by novel mechanisms involving new pharmaceutical products. Therefore, it is important to understand the basic toxicity-related changes described herein.",signatures:"Katsuhiko Yoshizawa, Michiko Yuki and Airo Tsubura",downloadPdfUrl:"/chapter/pdf-download/51626",previewPdfUrl:"/chapter/pdf-preview/51626",authors:[{id:"186317",title:"Associate Prof.",name:"Katsuhiko",surname:"Yoshizawa",slug:"katsuhiko-yoshizawa",fullName:"Katsuhiko Yoshizawa"},{id:"186355",title:"Prof.",name:"Airo",surname:"Tsubura",slug:"airo-tsubura",fullName:"Airo Tsubura"},{id:"186356",title:"Dr.",name:"Michiko",surname:"Yuki",slug:"michiko-yuki",fullName:"Michiko Yuki"}],corrections:null},{id:"51996",title:"Hepatic and Intestinal Multidrug Resistance-Associated Protein 2: Transcriptional and Post-transcriptional Regulation by Xenobiotics",doi:"10.5772/64755",slug:"hepatic-and-intestinal-multidrug-resistance-associated-protein-2-transcriptional-and-post-transcript",totalDownloads:1721,totalCrossrefCites:1,totalDimensionsCites:6,hasAltmetrics:0,abstract:"We are daily exposed to a large number of pharmacological drugs, environmental pollutants, and natural toxins, which represent a potential toxic insult. The organism possesses a sophisticated system of detoxification particularly expressed in the liver, intestine, and kidney. This system consists of intracellular biotransformation enzymes that convert the toxins into more hydrophilic derivatives followed by their elimination through membrane transporters. Multidrug resistance-associated protein 2 (MRP2, ABCC2) is an important member of the ATP-binding cassette (ABC) superfamily of transporters localized at the apical membrane of polarized cells, such as hepatocytes, enterocytes, and renal tubular cells. MRP2 is proposed as a major actor in the elimination of endo- and xenobiotics, mainly conjugated with glucuronic acid, glutathione, and sulfate. The small intestine and the liver constitute relevant detoxification organs expressing MRP2 and therefore preventing absorption and promoting the hepatobiliary clearance of xenobiotics. MRP2 expression and/or function can be modulated by therapeutic drugs, herbal products, dietary compounds, and environmental pollutants. Consequently, MRP2 modulation could cause changes in tissue exposure, with potential toxicological and pharmacological consequences. This chapter reviews the information available on the role of hepatic and intestinal MRP2 in detoxification processes, and their regulation by xenobiotics, considering in particular its toxicological relevance.",signatures:"Maite R. Arana, Guillermo N. Tocchetti, Juan P. Rigalli, Aldo D.\nMottino, Fabiana García and Silvina S.M. Villanueva",downloadPdfUrl:"/chapter/pdf-download/51996",previewPdfUrl:"/chapter/pdf-preview/51996",authors:[{id:"186701",title:"Ph.D.",name:"Silvina",surname:"Villanueva",slug:"silvina-villanueva",fullName:"Silvina Villanueva"},{id:"194128",title:"Ms.",name:"Maite",surname:"Arana",slug:"maite-arana",fullName:"Maite Arana"},{id:"194129",title:"Mr.",name:"Guillermo",surname:"Tocchetti",slug:"guillermo-tocchetti",fullName:"Guillermo Tocchetti"},{id:"194130",title:"Dr.",name:"Juan",surname:"Rigalli",slug:"juan-rigalli",fullName:"Juan Rigalli"},{id:"194131",title:"Dr.",name:"Aldo",surname:"Mottino",slug:"aldo-mottino",fullName:"Aldo Mottino"},{id:"194132",title:"Dr.",name:"Fabiana",surname:"García",slug:"fabiana-garcia",fullName:"Fabiana García"}],corrections:null},{id:"51876",title:"Nanotoxicology: A Review",doi:"10.5772/64754",slug:"nanotoxicology-a-review",totalDownloads:2998,totalCrossrefCites:13,totalDimensionsCites:26,hasAltmetrics:1,abstract:"Nanotoxicology represents a new and growing research area in toxicology. It deals with the assessment of the toxicological properties of nanoparticles (NPs) with the intention of determining whether (and to what extent) they pose an environmental or societal threat. Inherent properties of NPs (including size, shape, surface area, surface charge, crystal structure, coating, and solubility/dissolution) as well as environmental factors (such as temperature, pH, ionic strength, salinity, and organic matter) collectively influence NP behavior, fate and transport, and ultimately toxicity. The mechanisms underlying the toxicity of nanomaterials (NMs) have recently been studied extensively. Reactive oxygen species (ROS) toxicity represents one such mechanism. An overproduction of ROS induces oxidative stress, resulting in inability of the cells to maintain normal physiological redox-regulated functions. In the context of this book, this chapter includes topics pertaining to chemical and physical properties of NMs and characterization for proper toxicological evaluation, exposure, and environmental fate and transport, and ecological and genotoxic effects. This chapter reviews the available research pertaining specifically to NMs in the aquatic environment (in plants, aquatic invertebrates, and fish) and their use in biomarker studies.",signatures:"Chavon Walters, Edmund Pool and Vernon Somerset",downloadPdfUrl:"/chapter/pdf-download/51876",previewPdfUrl:"/chapter/pdf-preview/51876",authors:[{id:"176939",title:"Dr.",name:"Chavon",surname:"Walters",slug:"chavon-walters",fullName:"Chavon Walters"}],corrections:null},{id:"51839",title:"Potential Harm of Maltodextrin‐Coated Cadmium Sulfide Quantum Dots in Embryos and Fetuses",doi:"10.5772/64653",slug:"potential-harm-of-maltodextrin-coated-cadmium-sulfide-quantum-dots-in-embryos-and-fetuses",totalDownloads:1612,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Over the past years, there has been significant interest in the study of nanoparticles for clinical applications, particularly quantum dots (QDs). However, previous studies have also shown that QDs can reach the embryo through the placenta, a natural barrier for a large variety of organic substances with diverse molecular structures, and may cause developmental deformities. Due to its essential role in a toxicological profile and its relevance to human safety, knowledge regarding embryotoxicity is of great importance. Previous studies by this research group have shown that CdS‐maltodextrin QDs are biocompatible and nontoxic to cells and animals; however, QDs are able to induce embryotoxic effects. Therefore, as an effort to further address the issue, we studied the effects of CdS‐maltodextrin QDs on embryo and fetus development using an embryotoxicity and teratogenicity assay on chicken embryos. Chicken embryos exposed to CdS‐maltodextrin QDs (0.001, 0.01, 0.1 and 1 µg/kg) in ovo for 72 h showed growth and developmental alterations during the early stage and at the end of their development in a dose‐dependent manner. Decreased development was observed during early stages (Stages 9/10 on the Hamburger‐Hamilton scale) when compared with untreated eggs (Stage 13). Chicken embryos exposed to lower CdS‐maltodextrin QDs doses (0.01, 0.1 and 1 ng/kg) and incubated in ovo for 21 h also showed growth and development alterations during the early stages and at the end of their development in a dose‐dependent manner. However, reduced development was observed at the end of the development period (21 days), and this was associated with death of the chick. Current studies have also shown that CdS‐dextrin induces embryotoxicity and teratogenicity, affecting mainly the CNS, the neural tube and somites in chicken embryos. The nature of the observed abnormalities suggests that these effects could be directly associated with nanoparticle concentrations affecting somitogenesis. Therefore, according to the results, there is a high probability that the prolonged accumulation of QDs in the maternal organism may be potentially harmful on embryo and fetus development. This study is limited to the analysis of embryotoxic and teratogenic effects induced by CdS‐maltodextrin QDs.",signatures:"Jorge Reyes‐Esparza, Janet Sánchez‐Quevedo, Antonieta Gómez‐\nSolís, Patricia Rodríguez‐Fragoso, Gerardo González De la Cruz and\nLourdes Rodríguez‐Fragoso",downloadPdfUrl:"/chapter/pdf-download/51839",previewPdfUrl:"/chapter/pdf-preview/51839",authors:[{id:"141589",title:"Prof.",name:"Lourdes",surname:"Rodriguez-Fragoso",slug:"lourdes-rodriguez-fragoso",fullName:"Lourdes Rodriguez-Fragoso"},{id:"193799",title:"Dr.",name:"Jorge",surname:"Reyes-Esparza",slug:"jorge-reyes-esparza",fullName:"Jorge Reyes-Esparza"},{id:"193800",title:"Mrs.",name:"Janet",surname:"Sánchez-Quevedo",slug:"janet-sanchez-quevedo",fullName:"Janet Sánchez-Quevedo"},{id:"193801",title:"Dr.",name:"Antonieta",surname:"Gómez-Solïs",slug:"antonieta-gomez-solis",fullName:"Antonieta Gómez-Solïs"},{id:"193802",title:"Prof.",name:"Lourdes",surname:"Rodriguez-Fragoso",slug:"lourdes-rodriguez-fragoso",fullName:"Lourdes Rodriguez-Fragoso"},{id:"193803",title:"Dr.",name:"Patricia",surname:"Rodriguez-Fragoso",slug:"patricia-rodriguez-fragoso",fullName:"Patricia Rodriguez-Fragoso"},{id:"193804",title:"Dr.",name:"Gerardo",surname:"González-De La Cruz",slug:"gerardo-gonzalez-de-la-cruz",fullName:"Gerardo González-De La Cruz"}],corrections:null},{id:"52341",title:"Environmental Fate of Zinc Oxide Nanoparticles: Risks and Benefits",doi:"10.5772/65266",slug:"environmental-fate-of-zinc-oxide-nanoparticles-risks-and-benefits",totalDownloads:3628,totalCrossrefCites:12,totalDimensionsCites:27,hasAltmetrics:0,abstract:"Zinc oxide nanoparticles (ZnO-NPs) are among nanoscale materials displaying exponentially growing production due to their applications in the field of cosmetology, medicine, as antibacterial agent and catalyst. The ZnO nanomaterials release into the aquatic ecosystems through domestic and industrial wastewaters has the potential to induce pernicious effects on fish and other organisms. Increasing concerns on the environmental hazard to aquatic biota have been highlighted by the toxic potential of some metal-based nanomaterials. Several characteristics of ZnO-NPs (e.g. size, shape, surface charge and agglomeration state) play a central role in biological effects such as genotoxic, mutagenic or cytotoxic effects. Overall, Zn bioaccumulation, histopathological, and hematological changes with oxidative and cellular stress have been reported in ZnO-NPs exposed animals.",signatures:"Asfina Beegam, Parvathy Prasad, Jiya Jose, Miguel Oliveira,\nFernando G. Costa, Amadeu M.V.M. Soares, Paula P. Gonçalves, Tito\nTrindade, Nandakumar Kalarikkal, Sabu Thomas and Maria de\nLourdes Pereira",downloadPdfUrl:"/chapter/pdf-download/52341",previewPdfUrl:"/chapter/pdf-preview/52341",authors:[{id:"30304",title:"Prof.",name:"Tito",surname:"Trindade",slug:"tito-trindade",fullName:"Tito Trindade"},{id:"79715",title:"Prof.",name:"Maria De Lourdes",surname:"Pereira",slug:"maria-de-lourdes-pereira",fullName:"Maria De Lourdes Pereira"},{id:"146943",title:"Prof.",name:"Sabu",surname:"Thomas",slug:"sabu-thomas",fullName:"Sabu Thomas"},{id:"174419",title:"Prof.",name:"Fernando",surname:"Garcia E Costa",slug:"fernando-garcia-e-costa",fullName:"Fernando Garcia E Costa"},{id:"194616",title:"BSc.",name:"Asfeena",surname:"Began",slug:"asfeena-began",fullName:"Asfeena Began"},{id:"194617",title:"BSc.",name:"Parvathy",surname:"Prasad",slug:"parvathy-prasad",fullName:"Parvathy Prasad"},{id:"194618",title:"Dr.",name:"Jhose",surname:"Jyia",slug:"jhose-jyia",fullName:"Jhose Jyia"},{id:"194619",title:"Prof.",name:"Miguel",surname:"Oliveira",slug:"miguel-oliveira",fullName:"Miguel Oliveira"},{id:"194620",title:"Prof.",name:"Amadeu",surname:"M.V.M. Soares",slug:"amadeu-m.v.m.-soares",fullName:"Amadeu M.V.M. Soares"},{id:"194621",title:"Prof.",name:"Paula",surname:"Gonçalves",slug:"paula-goncalves",fullName:"Paula Gonçalves"},{id:"194622",title:"Dr.",name:"Nandakumar",surname:"Kalarikkal",slug:"nandakumar-kalarikkal",fullName:"Nandakumar Kalarikkal"}],corrections:null},{id:"52031",title:"Microplastics in Aquatic Environments and Their Toxicological Implications for Fish",doi:"10.5772/64815",slug:"microplastics-in-aquatic-environments-and-their-toxicological-implications-for-fish",totalDownloads:3189,totalCrossrefCites:10,totalDimensionsCites:25,hasAltmetrics:1,abstract:"The intensive use of plastics and derivatives during the last century has increased the contamination of animal habitats. The breakdown of these primary plastics in the environment results in microplastics (MP), small fragments of plastic typically <1–5 mm in size. Apart from the potential negative effects of the MPs per se, it is generally assumed that microplastics may increase the exposure of marine aquatic organisms to chemicals associated with the plastics. In addition, to enhance the performance of plastics, additives are added during manufacture. Furthermore, they are active in absorbing other contaminants and be used as vectors of highly and well‐documented persistent contaminants. Finally, these small MPs are easily ingested by animals and affect their physiology and behaviour. Thus, aquatic living organisms are continuously exposed to these MPs, and associated contaminants, and could suffer from its contamination but also introduce them into the food chain.",signatures:"Cristóbal Espinosa, M. Ángeles Esteban and Alberto Cuesta",downloadPdfUrl:"/chapter/pdf-download/52031",previewPdfUrl:"/chapter/pdf-preview/52031",authors:[{id:"28342",title:"Dr.",name:"M. Ángeles",surname:"Ăngeles Esteban",slug:"m.-angeles-angeles-esteban",fullName:"M. Ángeles Ăngeles Esteban"},{id:"72817",title:"Dr.",name:"Alberto",surname:"Cuesta",slug:"alberto-cuesta",fullName:"Alberto Cuesta"},{id:"194251",title:"Dr.",name:"Cristobal",surname:"Espinosa",slug:"cristobal-espinosa",fullName:"Cristobal Espinosa"}],corrections:null},{id:"51891",title:"Biotests in Ecotoxicology: Current Practice and Problems",doi:"10.5772/64776",slug:"biotests-in-ecotoxicology-current-practice-and-problems",totalDownloads:2041,totalCrossrefCites:4,totalDimensionsCites:10,hasAltmetrics:0,abstract:"Nowadays ecotoxicology plays the role of a theoretician – methodical unifying centre for the optimization of man – biosphere relations and sustainable existence of life on the Earth. The main basis for its development is the classical toxicology—studies of chemical compounds’ effects on man, but ecotoxicology is the original part, following it. According to the modern concept, the ecotoxicology is a science for migration, transformation and utilization of different toxic ingredients (with organic, inorganic or organic-mineral chemical nature; with natural biotic or abiotic origin and artificial, mainly anthropogenic origin) in the environment and their impact on Macro- biological systems with different levels of integration as groups of individuals, population, community, ecosystem, etc. studied in ecology. In this chapter, the types of ecotoxicological tests are discussed in detail with a set of examples about used species, advantages and disadvantages of different types of toxicity testing. The application of exposed natural ecosystems or man-made analogue systems is also commented as the environmentally more realistic approach for ecotoxicological testing. These test systems are increasingly becoming in aquatic ecotoxicology practice, but they are contemporary challenge in terrestrial testing. The development of test systems for realistic assessment of contaminant toxicity is essential for the efficient control of human influence on the environment.",signatures:"Mariyana Lyubenova and Silvena Boteva",downloadPdfUrl:"/chapter/pdf-download/51891",previewPdfUrl:"/chapter/pdf-preview/51891",authors:[{id:"187225",title:"Dr.",name:"Mariyana",surname:"Lyubenova",slug:"mariyana-lyubenova",fullName:"Mariyana Lyubenova"},{id:"194135",title:"Dr.",name:"Silvena",surname:"Boteva",slug:"silvena-boteva",fullName:"Silvena Boteva"}],corrections:null},{id:"52207",title:"A Review of Cyanogenic Glycosides in Edible Plants",doi:"10.5772/64886",slug:"a-review-of-cyanogenic-glycosides-in-edible-plants",totalDownloads:7524,totalCrossrefCites:19,totalDimensionsCites:50,hasAltmetrics:1,abstract:"Cyanogenic glycosides are natural plant toxins that are present in several plants, most of which are consumed by humans. Cyanide is formed following the hydrolysis of cyanogenic glycosides that occur during crushing of the edible plant material either during consumption or during processing of the food crop. Exposure to cyanide from unintentional or intentional consumption of cyanogenic glycosides may lead to acute intoxications, characterized by growth retardation and neurological symptoms resulting from tissue damage in the central nervous system (CNS). Processing methods can detoxify cyanogenic glycosides and reduce the risk of cyanide poisoning. The efficiency of cyanide removal, however, depends on the processing technique employed and the extent of processing. Processing operations such as fermentation, boiling/cooking, and drying, applied to process food‐containing cyanogenic glycosides have been reported to reduce cyanide content to acceptably safe levels. The present review discusses the level of cyanogenic glycosides in specific plant foods, health implications of consuming cyanogenic plants and effect of various processing method on cyanogenic glycosides with updated information gathered from the published reports on cyanogenic glycosides.",signatures:"Islamiyat Folashade Bolarinwa, Moruf Olanrewaju Oke, Sulaiman\nAdebisi Olaniyan and Adeladun Stephen Ajala",downloadPdfUrl:"/chapter/pdf-download/52207",previewPdfUrl:"/chapter/pdf-preview/52207",authors:[{id:"190129",title:"Dr.",name:"Islamiyat Folashade",surname:"Bolarinwa",slug:"islamiyat-folashade-bolarinwa",fullName:"Islamiyat Folashade Bolarinwa"},{id:"194068",title:"Dr.",name:"Sulaiman Adebisi",surname:"Olaniyan",slug:"sulaiman-adebisi-olaniyan",fullName:"Sulaiman Adebisi Olaniyan"},{id:"194071",title:"Dr.",name:"Adeladun Steven",surname:"Ajala",slug:"adeladun-steven-ajala",fullName:"Adeladun Steven Ajala"},{id:"194073",title:"Dr.",name:"Moruf Olanrewaju",surname:"Oke",slug:"moruf-olanrewaju-oke",fullName:"Moruf Olanrewaju Oke"}],corrections:null},{id:"51762",title:"Toxic Effects as a Result of Herbal Medicine Intake",doi:"10.5772/64468",slug:"toxic-effects-as-a-result-of-herbal-medicine-intake",totalDownloads:4467,totalCrossrefCites:12,totalDimensionsCites:23,hasAltmetrics:1,abstract:"Concurrent use of herbs with therapeutic drugs increases the potential of herb-drug interactions. The clinical importance of herb-drug interactions is associated with the particular herb, drug, and patient profile. Herbs are potentially potent as they affect body functions. The use herbal medicine and supplements can be risky as they are not subject to review by the FDA. In this chapter, we make an attempt to discuss the possible reasons for toxic effects, types of toxicities, some reported cases of toxicities involving the use of herbal medicine alone, and some herb-drug interactions. In addition to this, possible ways to reduce toxic effects of herbal medicines have also been discussed.",signatures:"Nudrat Fatima and Naira Nayeem",downloadPdfUrl:"/chapter/pdf-download/51762",previewPdfUrl:"/chapter/pdf-preview/51762",authors:[{id:"186023",title:"Dr.",name:"Nudrat",surname:"Fatima",slug:"nudrat-fatima",fullName:"Nudrat Fatima"},{id:"186802",title:"Dr.",name:"Naira",surname:"Nayeem",slug:"naira-nayeem",fullName:"Naira Nayeem"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"923",title:"Herbicides",subtitle:"Theory and Applications",isOpenForSubmission:!1,hash:"54a8eb808c05a5fe01c676e7047d4576",slug:"herbicides-theory-and-applications",bookSignature:"Sonia Soloneski and Marcelo L. 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These approaches enhance the overall quality of treatment and overcome the unprecedented side effects of available therapies. The purpose of this book will mainly be to collect the already available scholarly literature relevant to pharmaceutical technology and existing pharmaceutical technologies that can be harnessed in a good manner for the upliftment of patients suffering from undue side effects. Furthermore, this book will aim to serve as a reference book for the industrial personnel who wish to work on novel pharmaceutical dosage forms. The book will mainly intend to focus on both academics and industrial personnel who want to understand and implicate the knowledge of conventional dosage forms in novel pharmaceutical systems by considering the translational approach and regulatory challenges.
\r\n\t
The existing literature on MANETs is very extensive. An extremely comprehensive work is presented in Refs. [1, 2], which extensively covers most issues related to the subject, whereas in Refs. [3, 4], authors provide a brief introduction. MANET design issues such as a routing architecture in the light of the nature of MANETS, unidirectional link support, QoS routing, and multicast support are discussed in Refs. [5, 6]. In Ref. [7], the authors cover some of the same design issues as mentioned in Ref. [5], but they augment them with some additional ones, such as limited bandwidth, energy constrained operation, and limited physical security.
\nCommunication networks are evolving with a great pace witnessing increase in infrastructure and applications too. A mobile ad hoc network is the latest outcome in this research. The mobile ad hoc network, also known as MANET [8], is a network without any available infrastructure.
\nNodes are mobile and can move whenever and wherever they want, because there is no centralized control or any other infrastructure is needed in any MANET. Each node in an MANET must be capable of functioning as a router to relay the traffic of other nodes.
\nA number of protocols have been developed for accomplish this task. Various dedicated routing protocols have been proposed to the Internet Engineering Task Force (IETF) MANET Working Group [8]. Some of these protocols have been studied, and their performances have been analyzed in detail. Broch et al. [9] evaluated four protocols using mobility and traffic scenarios similar to those we used. They focused on packet loss, routing message overhead, and route length. In Ref. [10], Johansson et al. compare three routing protocols, over extensive scenarios, varying node mobility, and traffic load. They focus on packet loss, routing overhead, throughput, and delay, and introduce mobility measures in terms of node relative speed. Finally, in Ref. [11], Das and coworkers compare the performance of two protocols, focusing on packet loss, packet end-to-end delay, and routing load. They obtained simulation results consistent with previous works and conclude with some recommendations for improving protocols. In this chapter, we measure and compare three performance parameter behaviors of two routing protocols, respectively, ad hoc on demand distance vector (AODV) [12] and destination-sequenced distance vector (DSDV).
This is the leading routing protocol proposed so for in the category of on demand or reactive routing protocols. Unlike table-driven protocols, it does not maintain status of the network via continuous updates [13]. This approach assists in minimizing the flooded messages and also size of route tables. It was designed after a distance vector routing protocol (DSDV) but is much efficient than DSDV. Actually, AODV is a combination of DSDV and dynamic source routing (DSR). It has the actual on-demand technique of discovering the route and also route maintenance from DSR but uses sequence numbering and also the periodic beacons of DSDV. New routes are found through the process of RREQ and RREP where RREQ packets are broadcast and RREPs are unicast in nature. While route maintenance uses RERR packets for remedy of route breaks, routing information is kept afresh by the usage of sequence numbers, which is the idea borrowed from DSDV [14].
\nThe DSDV [15] is a proactive routing algorithm based upon a well-known classical distance vector algorithm of Bellman-Ford. Routing tables are maintained and updated accordingly, so broadcast periodic routing table update packets consume the bandwidth. So, the main weakness of DSDV is that when network grows these packets also increase. The main improvement here to the Bellman-Ford algorithm is loop freedom, which is made possible by assigning the sequence number to each entry in the routing table, which avoids stale routes.
\nThe dynamic source routing (DSR) [10] is an on-demand or reactive routing protocol. Therefore, unlike other proactive routing protocols, DSR involves no updates of whichever type at any stage inside the network. The DSR uses source routing for forwarding data packets, which distinguishes DSR from other reactive routing protocols. It is lightweight on inner routers due to source routing, the maintaining routing information is not needed at every host. The sender becomes aware of complete destination address before transmission and appends this address in the header of the routing data packet at the beginning. It is loop free due to source routing. Extensive use of cache and promiscuously listening are the main optimizations to DSR when network is at low mobility.
The simulation software used in this chapter is the network simulator, NS-2 [16, 17]. The software version used is the latest release at the time of the commencement of simulation, namely, ns-2.34, which can be downloaded from Ref. [17]. In addition, many existing ad hoc routing protocol modules have already been implemented in NS-2. Three such protocols are AODV, DSR, and DSDV. NS-2 is a discrete-event-driven simulation software targeted for network simulation. This software is currently maintained by the Information Science Institute of University of Southern California.
\nIn order to analyze and compare the performance of the three routing protocols AODV, DSR, and DSDV, simulation experiments were performed. The purpose of the simulations was to compare the efficiency of the routing protocols based on different simulation parameters. The focus was concentrated on four performance metrics:
\nPacket delivery ratio (PDR).
Throughput.
Normalized routing overhead.
Jitter.
Generated trace file that is (.tr)
\nr -t 2.046566484 -Hs 1 -Hd -1 -Ni 1 -Nx 454.33 -Ny 337.37 -Nz 0.00 -Ne 9.996194 -Nl RTR -Nw — -Ma 0 -Md ffffffff -Ms 4 -Mt 800 -Is 1.255 -Id 9.255 -It DSR -Il 48 -If 0 -Ii 17 -Iv 32 -P dsr -Ph 2 -Pq 1 -Ps 2 -Pp 0 -Pn 2 -Pl 0 -Pe 0->16 -Pw 0 -Pm 0 -Pc 0 -Pb 0->0
NAM is a Tcl/TK-based animation tool for viewing network simulation traces and real-world packet traces. Taking data from network simulators (such as ns) or live networks, NAM was one of the first tools to provide general purpose, packet-level, and network animation, before starting to use NAM, a trace file needs to create [16]. This trace file is usually generated by NS. Once the trace file is generated, NAM can be used to animate it. A snapshot of the simulation topology in NAM for 15 mobile nodes is shown in Figure 1, which is visualized the traces of communication or packet movements between mobile nodes [17].
A simple NAM file output.
The NAM file output for packet dropping is shown in Figure 2.
A NAM output with packet dropping.
Packet delivery ratio (PDR) is defined as the ratio of data packets delivered successfully to destination nodes and the total number of data packets generated for those destinations. PDR characterizes the packet loss rate, which limits the throughput of the network. The higher the delivery ratio, better the performance of the routing protocol. The ratio of the data delivered to the destination to the data sent out by the source. PDR is determined as
\nFigures 3–6 clearly indicate that the AODV routing protocol outcomes are better with the CBR traffic. AODV protocol performs better in comparison of other two selected routing protocols in such a network environment with varying speeds of nodes. So, we conclude that AODV is better in most of the PDR cases.
Packet delivery ratio (PDR) at 3 m/s.
Packet delivery ratio (PDR) at 10 m/s.
Packet delivery ratio (PDR) at 25 m/s.
Packet delivery ratio (PDR) at 50 m/s.
Throughput is defined as the ratio of the total data reaches a receiver from the sender. The time it takes by the receiver to receive the last message is called as throughput. Throughput is expressed as bytes or bits per sec (byte/sec or bit/sec). Some factors affect the throughput as; if there are many topology changes in the network, unreliable communication between nodes, limited bandwidth available, and limited energy. A high throughput is absolute choice in every network. Throughput can be represented mathematically as in equation. This represents the number of packets received by the destination within a given time interval. It is a measure of effectiveness of a routing protocol.
\nThe analysis of Figures 7–10 shows that performance of AODV is better than DSR and DSDV. Another characteristic that has come to the notice is that pause time does not have significant bearing on the throughput, whereas the performance is dictated only by the density of the network.
Throughput at 3 m/s.
Throughput at 10 m/s.
Throughput at 25 m/s.
Throughput at 50 m/s.
This is the ratio of routing-related transmissions (RREQ, RREP, RERR, etc.) to data transmissions in a simulation. A transmission is one node either sending or forwarding a packet. Either way, the routing load per unit data successfully delivered to the destination.
\nIt is the total number of control or routing (RTR) packets generated by routing protocol during the simulation. All packets sent or forwarded at network layer is consider routing overhead.
\nBased on the result of simulation, Figures 11–14 show that the performance of DSDV is better than AODV and DSR. At all the considered mobility, DSDV is the best protocol as compared to other protocols.
Normalized routing overhead at 3 m/s.
Normalized routing overhead at 10 m/s.
Normalized routing overhead at 25 m/s.
Normalized routing overhead at 50 m/s.
The term jitter is often used as a measure of the variability over time of the packet latency across a network. A network with constant latency has no variation (or jitter). Packet jitter is expressed as an average of the deviation from the network mean latency. However, for this use, the term is imprecise [13]. Or in other words, jitter is the variation of the packet arrival time. In jitter calculation, the variation in the packet arrival time is expected to minimum. The delays between the different packets need to be low if we want better performance in mobile ad hoc networks.
\nBased on the result of simulation, Figures 15 and 16 show that the performance of AODV and DSR gives the better result. Figures 17 and 18 show that DSR gives the better performance.
Jitter at 3 m/s.
Jitter at 10 m/s.
Jitter at 25 m/s.
Jitter at 50 m/s.
Analysis of variance (ANOVA) is a collection of statistical models used to analyze the differences between group means and their associated procedures (such as “variation” among and between groups), in which the observed variance in a particular variable is partitioned into components attributable to different sources of variation [18].
\nIn this chapter, we have use one-way ANOVA. One-way ANOVA is used to study the effect of (
The packet delivery ratio (PDR) is very much related to the throughput metric. The destination records the number of data packets it received and estimates the PDR delivery ratio in the network from the count of the data packets sent. The ANOVA hypothesis test is shown in Table 1, there is sufficient evidence to reject the null hypothesis. We see that there is a significant different in PDR performance when the network adopts different routing methods (
Groups | Count | Sum | Average | Variance |
---|---|---|---|---|
AODV | 23 | 802.8693 | 34.90736 | 121.3164733 |
DSDV | 23 | 744.1666 | 32.35507 | 171.2711624 |
DSR | 23 | 729.8366 | 31.73203 | 56.06334723 |
Summary of packet delivery ratio.
The one-way ANOVA test for PDR is shown in Table 2.
SS | Df | MS | ||||
---|---|---|---|---|---|---|
Between groups | 130.21925 | 2 | 65.10963 | 0.560241875 | 0.573763 | 3.135918 |
Within groups | 7670.3216 | 66 | 116.217 | |||
Total | 7800.5409 | 68 |
ANOVA of packet delivery ratio.
In this case,
Data throughput is defined as the total number of packets delivered over the total simulation time. ANOVA statistical computation shows that we do not reject the null hypothesis. That is, there is no significant difference for the different methods in terms of throughput performance (
Groups | Count | Sum | Average | Variance |
---|---|---|---|---|
AODV | 23 | 7990941 | 347432.2 | 8201779957 |
DSDV | 23 | 8094695 | 351943.3 | 20237752574 |
DSR | 23 | 7267943 | 315997.5 | 5554377965 |
Summary of throughput.
The one-way ANOVA test for throughput is shown in Table 4.
Source of variation | SS | df | MS | |||
---|---|---|---|---|---|---|
Between groups | 1.764E+10 | 2 | 8.82E+09 | 0.778278814 | 0.463364 | 3.135918 |
Within groups | 7.479E+11 | 66 | 1.13E+10 | |||
Total | 7.655E+11 | 68 |
ANOVA of throughput.
In this case,
Using the ANOVA hypothesis testing, the simulation results show a significant difference among methods used in terms of normalized routing overhead (
Groups | Count | Sum | Average | Variance |
---|---|---|---|---|
AODV | 23 | 2.19207 | 0.095307 | 0.01199388 |
DSDV | 23 | 13.66286 | 0.594037 | 0.846600923 |
DSR | 23 | 0.528887 | 0.022995 | 0.000264522 |
Summary of normalized routing overhead.
The one-way ANOVA test for normalized routing overhead is shown in Table 6.
Source of variation | SS | df | MS | |||
---|---|---|---|---|---|---|
Between groups | 4.4470485 | 2 | 2.223524 | 7.766781596 | 0.000935 | 3.135918 |
Within groups | 18.894905 | 66 | 0.286286 | |||
Total | 23.341954 | 68 |
ANOVA of normalized routing overhead.
In this case,
The term jitter often used as a measure of the packet of the variability over time of the packet latency across a network. A network with constant latency has no variation (or jitter). Packet jitter is expressed as an average of the derivation from the network mean latency. ANOVA statistical computation shows that we do not reject the null hypothesis. That is, there is no significant difference for the different methods in terms of throughput performance (
Groups | Count | Sum | Average | Variance |
---|---|---|---|---|
AODV | 23 | 0.129171 | 0.005616 | 2.07E−06 |
DSDV | 23 | 0.125752 | 0.005467 | 5.9E−06 |
DSR | 23 | 0.131442 | 0.005715 | 1.91E−06 |
Summary of jitter.
The one-way ANOVA test for jitter is shown in Table 8.
SS | df | MS | ||||
---|---|---|---|---|---|---|
Between Groups | 7.14E−07 | 2 | 3.57E−07 | 0.108241 | 0.89757 | 3.135918 |
Within Groups | 0.000218 | 66 | 3.3E−06 | |||
Total | 0.000218 | 68 |
ANOVA of jitter.
In this case,
The results indicate that the performance is better especially when the number of nodes in the network is higher. In this chapter, we have used a simulator that provides the virtual environment for the testing different parameters. Reactive routing protocol AODV performance is the best considering due to its ability to maintain connection by periodic exchange of information. Using NS-2 simulator we created the scenarios under which using tcl script, it is run. After analyzing the X-graphs, we concluded that AODV indicates its highest efficiency and performance under high mobility than DSR and DSDV, and the performance of TCP and UDP packets with respect to normalized routing overhead, jitter, throughput, and PDR, and the performance of AODV is better than DSDV and DSR routing protocol for real-time applications from the simulation results.
\nAfter that in one-way ANOVA test, AODV exhibits better routing performance compared with conventional routing methods such as DSDV and DSR. By performing an ANOVA analysis at the initial stage, we conclude that there is a significant difference in the performance metrics when using different routing algorithms. From there, we analyze the difference of the means and boundaries in 95% confidence interval. In all simulation scenarios, we see that AODV shows a lower packet loss and lower delay. It offers higher throughput and ensures higher packet delivery ratio.
The knowledge of using of plants and herbs as medicines and for the treatment of many kinds of diseases and for healthy living is handed over from generation to generation in all the communities. Numerous traditional uses of plants and herbs for medicinal purposes have been documented and published time by time. Mankind has been continuously using the medicinal plants in several ways for treating of various ailments and for cosmetics purposes. In India, the sacred Vedas dating back between 3500 B.C and 800 B.C gave many references of medicinal plants. “Virikshayurveda is one of the oldest works in traditional herbal medicine in India, which is compiled even before the beginning of Christian era and it formed the basis of medicinal studies in ancient India. Knowledge of herbs has been handed down from generation to generation for thousands of years and herbal drugs constitute a major part in all traditional systems of medicines. Plants have been used for medicine from time immemorial because they are easily accessible and cheap and above all they were the only means for healthcare. Recently, there has been a tremendous increase in the use of herbal products in many countries, both developing and developed, which resulted in an exponential growth of herbal products globally. Herbal medicines have a strong traditional or conceptual base and the potential for them to be useful as drugs in terms of safety and effectiveness, leads for treating different diseases. Many of the population in the developing and underdeveloped countries still depend on herbal medicine where access to modern medicine is little [1]. Plants continue to serve as possible sources for developing new drugs from the chemicals derived from various parts of plants. In recent time there has been a marked shift towards herbal cures because of the adverse and noticeable side effects of modern drugs. However, due to increase in population, deforestation, roads and railways, urbanization and unsustainable harvesting and collection from the wild, many useful plant species along with their uses are disappearing every day. Unsustainable and injudicious extractions of these medicinal plants have pushed some of the important species towards extinction. An important anti cancerous plant,
State | District | Village/region | Local name |
---|---|---|---|
Arunachal Pradesh | Kameng, Subansiri, Kurung Kume, Siang, Lohit, Tirap and Changlang | — | Do-Tala |
Manipur | Senapati | Hengbung, Maram, Purul and Ma-kui regions | Singpan |
Tamenglong | Puilong Village | ||
Uttarakhand | — | — | Satwa |
Himachal Pradesh | — | — | — |
Jammu & Kashmir | — | — | — |
Mizoram | — | — | — |
Sikkim | — | — | — |
Nagaland | Tuensang | Pangsha village | — |
Phek | Chida region | ||
Kohima | Arudara region | ||
Mokokchung | Longkum village | ||
Meghalaya | West Khasi Hill | Nongstoin region | Sohbsein |
As of May 2012 the World Checklist of Selected Plant Families (WCSP) recognizes several varieties [8, 9].
The Flora of China recognizes five additional varieties, three of which are placed in different species by the WCSP:
Arunkumar Phurailatpam, College of Horticulture and Forestry, Central Agricultural University, Pasighat, Arunachal Pradesh, India.
Different varieties of
Variety | Description |
---|---|
Style and apical part of ovary white | |
Anthers about twice as long as filaments | |
Filaments can grow to about 10 mm; stigma lobes | |
Ovary and capsule tuberculate Ovary and capsule smooth | |
Filaments 1–2 mm; anthers around 6 mm | |
Plants about 10 cm tall; free portion of anther connective inconspicuous | |
Leaf blade oblong, elliptic, or obovate—lanceolate, 2.5–5.0 cm wide | |
Leaf blade lanceolate to linear-lanceolate; 1.5–2.5 cm wide | |
Inner tepals are 3–5 mm wide; distally widened sometimes; narrowly spatulate |
Different varieties of
Source: Flora of China (online),eFloras.org, retrieved 11 February 2015.
This plant has many uses in traditional health care in many countries especially in China and Nepal. Some of the uses are as/in analgesic, removes heat, antispasmodic, antitussive, depurative, snake bites, boils and ulcers, diphtheria and epidemic Japanese B encephalitis, stomach ache, appendicitis, tonsillitis, insect bites, boils. It also counteracts toxicity, causes the subsidence of swelling, alleviates pain and relieves convulsions, boils, carbuncles, sore throat, traumatic pain, convulsions. It also has anti-tumor action.
Lee et al. [11] of the Department of Biochemistry, the Chinese University of Hong Kong reported that the steroidal saponin of
Yan et al. [12] of Tianjin University, China has reported that (Diosgenin-3-α-L-arabinfuranosyl (1-4)-[α-L-rhamnopyanosyl (1-2)]-β-D-Glycopyranoside), the main steroidal saponin of
While investigating the anti-cancer activity of 15 traditional Chinese medicines which are usually used for tumour patients in China, using MTT(methyl thiazolylt diphenyl-tetrazolium bromide) method on 6 human digestive tumour cell lines-human liver carcinoma cell lines (HepG2) and SMMC-7721), human gastric cancer cell lines (BGC-823), human colon adenocarcinoma cell line (LoVo and W-116) and oesophagus adenocarcinoma cell line (CaEs-17), it was found t ha t
Anti tumour constituents from
Diosgenin-3-O-α-L-arabinofuranosyl (1-4) β-D-glycopyranoside
Pennogenin-3-O-α-L-arabinofuranosyl (1-4) β-D-glycopyranoside
Isorhamn etin-3-O-β-D-glycopyranoside
Ethyl-α-D-fructofuranoside
Pennogenin-3-O-α-L-rhamnopyranosyl (1-4)[ α-L-rhamnopyranosyl(1-2)] β-D-glycopyranoside, and6.Pennogenin-3-O-α-L-rhamnopyranosyl (1-4) [α-L-rhamnopyranosyl (1-4)] α-L-[α-L-rhamnopyranosyl(1-2)] β-D-glycopyranoside.
In the study of three diosgenyl saponin compounds is olated from
The roots have shown anti bacterial action against
The plant extract showed effective spermicidal activity against rat and human sperms. The vaginal application of the plant’s extract (100 mg/animal) prevented pregnancy up to 60% of the rabbits tested [17].
Deng et al. in 2008 evaluated the anti-fungal activity of
The rhizome of the plant contains sugars (7.9%) and two glycosides viz a-paridin (m.p. 244–46°) and a-paristypnin (m.p. 147–49°) which produces a tingling sensation on the tongue. α-Paristypnin has a depressant action on carotid pressure, myocardium and respiratory movements. It produces vasoconstriction in kidney, vasodilation in the spleen and limbs and stimulates the intestines [17].
Devkota [17] isolated 6 (six) compounds from
The compounds are
Przewalskinone B (1,5-Dihydroxy-7-methoxy-3-methylanthraquinone) which has a anthraquinone skeleton Polyphyllin C (Diosgenin-3-O[α-Lrhamnopyanosyl(1-3)-β-D-glucopyranoside) which has a steroidal skeleton.
Polyphyllin D (Diosgenin-3-O[α-Lrhamnopyanosyl (1Rha-2Glu)-α-Larabinofuranosyl (1Ara-4Glu)]-β–D-Glucopyranoside) which has a steroidal skeleton
Saponin-1 (Diosgenin-3-O[α-L-rhamnopyanosyl (1Rha-2Glu)-α-L-rhamnopyranosyl (1Ara-4Glu)]-β-D-Glucopyranoside) which has a steroidal skeleton
Stigmasterol which is a steroid, and
Stigmasterol-3-O-β-D-glucoside.
A new saponin-polyphyllin A-H has been isolated from the rhizome of
A novel steroidal saponin along with the 12 known compounds were separated from
Diosgenin
Pennogenin
Diosgenin-3-
Pennogenin-3-
Diosgenin-3-
Pennogenin-3-
Diosgenin-3-
Pennogenin-3-
3-
2b,3b,14a,20b,22a,25b hexahydroxycholest-7-en-6-one, and
2b,3b,14a,20b,24b,25b hexahydroxycholest-7-en-6-one (Table 3)
Plant species | Isolated compounds |
---|---|
Paris saponin I (diosgenin3-O-α-L-rha-(1→2)-[α-L-arab-(1→4)]-β-D-glu) | |
Paris saponin I (diosgenin3-O-α-rha-(1→4)-α-L-rha-(1→4)-[α-L-rha-(1→2)]-β-D-glu) | |
Paris saponin III (diosgenin 3-O-α-L-rhamnopyranosyl-(1→2)-[α-L-rhamnopyranosyl-(1→4)]-β-D-glucopyranoside) | |
Polyphyllin VI (pennogenin-3-O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside) | |
Polyphyllin VII (pennogenin-3-O-α-L-rhamnopyranosyl-(1→4)-α-L-rhamnopyranosyl-(1→4)[O-β-D-glucopyranosyl-(1→2)]-β-D-glucopyranoside) | |
Saponin-1 (diosgenin-3-O[α-L-rhamnopyanosyl (1Rha-2Glu)-α-L-rhamnopyranosyl (1Ara-4Glu)]-β-glucopyranoside) | |
Polyphyllin C (diosgenin-3-O[α-L-rhamnopyanosyl(1→3)-α-D-glucopyranoside) | |
Polyphyllin D (diosgenin-3-O[α-L-rhamnopyanosyl (1Rha-2Glu)-α-L-arabinofuranosyl (1Ara-4Glu)]-β-D-glucopyranoside) | |
Przewalskinone B (1,5-Dihydroxy-7-methoxy-3-methylanthraquinone) | |
Stigmasterol | |
Stigmasterol-3-O-β-D-glucoside | |
Diosgenin | |
Pennogenin | |
Diosgenin-3-O-α-L-rhamnopyranosyl (1→2)-β-D-glucopyranoside | |
Pennogenin-3-O-α-L-rhamnopyranosyl(1→2)-β-D-glucopyranoside | |
Diosgenin-3-O-α-L-rhamnopyranosyl(1→2)[-α-L-arabinofuranosyl(1→4)]-β-D-glucopyranoside | |
Pennogenin-3-O-α-L-rhamnopyranosyl(1→2)[-α-L arabinofuranosyl (1→4)]-β-D-glucopyranoside | |
Diosgenin-3-O-α-L-rhamnopyranosyl(1→2)-[β-D-glucopyranoside(1→3)]-β-D-glucopyranoside | |
Diosgenin-3-O-α-L-rhamnopyranosyl (1→4)-α-L rhamnopyranosyl (1→4)[α-L-rhamnopyranosyl (1→2)]-β-D-glucopyranoside | |
Pennogenin-3-O-α-L-rhamnopyranosyl(1→4)-α-L-rhamnopyranosyl (1→4)[α-L-rhamnopyranosyl (1→2)]-β-D-glucopyranoside | |
3-O-α-L-arabinofuranosyl(1→4)[α-L-rhamnopyranosyl(1→2)]-β-D-glucopyranoside-β-D-chacotriosyl-26-O-β-D-glucopyranoside | |
2β, 3β, 14α, 20β, 22α, 25β hexahydroxycholest-7-en-6-one | |
2β,3β,14α, 20β,24β,25β hexahydroxycholest-7-en-6-one | |
3b, 21-dihydroxy pregnane-5-en-20S-(22,16)-lactone-1-O-α-L-rhamnopyranosyl (1→2)-[β-D-xylopyranosyl (1→3)]-β-D-glucopyranoside. | |
(25R)-spirost-5-en-3b,7b-diol-3-O-α-L-arabinofuranosyl-(1→4)-[α-L-rhamnopyranosyl-(1→2)]-β-D-glucopyranoside | |
(25R)-spirost-5-en-3b,7a-diol-3-O-α-L-arabinofuranosyl-(1→4)-[α-L-rhamnopyranosyl-(1→2)]-β-D-glucopyranoside | |
26-O-β-D-glucopyranosyl-(25R)-Δ 5(6) 17 ( 20)-dien-16,22-dione-cholestan-3b,26-diol-3-O-α-L-arabinofuranosyl-(1→4)-[α-L-rhamnopyranosyl-(1→2)]-β-D-glucopyranoside | |
26-O-β-D-glucopyranosyl-(25R)-5-ene-furost-3β,17α, 22α, 26-tetrol-3-O-α-L-arabinofuranosyl-(1→4)-[α-L-rhamnopyranosyl-(1→2)]-β-D-glucopyranoside | |
26-O-β-Dglucopyranosyl-(25R)-5, 20 (22)-diene-furost-3β, 26-diol-3-O-α-L-arabinofuranosyl-(1→4)-[α-L-rhamnopyranosyl-(1→2)]-β-D-glucopyranoside | |
(25R)-spirost-5-ene-3β, 12α-diol-3-O-α-L-rhamnopyranosyl-(1→4)-α-L-rhamnopyranosyl-(1→4)-[α-L-rhamnopyranosyl-(1→2)]-β-D-glucopyranoside | |
24-O-β-D-galactopyranosyl-(23S,24S,25S)-spirost-5-ene-1b,3b,21,23,24-pentol-1-O-α-L-rhamnopyranosyl-(1→ 2)-[β-D-xylopyranosyl-(1→3)]-β-D-glucopyranoside | |
21-O-β-D-galactopyranosyl-24-O-β-D-galactopyranosyl-(23S,24S)-spirost-5,25(27)-diene-1b,3b,21,23,24-pentol-1-O-α-L-rhamnopyranosyl-(1→ 2)-[β-D-xylopyranosyl-(1→3)]-β-D-glucopyranoside |
To preserve this natural resource and ensure a stable and renewable source of
This calls for an urgent need to discover alternate resources from which the continuous supply can be obtained. Domestication of this plant and cultivation in large scale in those areas similar to natural habitat is the only solution to save this plant from extinction. Propagation by tissue culture is another prospective for the propagation and conservation of this endangered plant species.
Local communities opined that the need of the risen market demand for its medicinal, biological and pharmaceutical purposes can be met once the
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His studies in robotics lead him not only to a PhD degree but also inspired him to co-found and build the International Journal of Advanced Robotic Systems - world's first Open Access journal in the field of robotics.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"441",title:"Ph.D.",name:"Jaekyu",middleName:null,surname:"Park",slug:"jaekyu-park",fullName:"Jaekyu Park",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/441/images/1881_n.jpg",biography:null,institutionString:null,institution:{name:"LG Corporation (South Korea)",country:{name:"Korea, South"}}},{id:"465",title:"Dr",name:"Christian",middleName:null,surname:"Martens",slug:"christian-martens",fullName:"Christian Martens",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"479",title:"Dr.",name:"Valentina",middleName:null,surname:"Colla",slug:"valentina-colla",fullName:"Valentina Colla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/479/images/358_n.jpg",biography:null,institutionString:null,institution:{name:"Sant'Anna School of Advanced Studies",country:{name:"Italy"}}},{id:"494",title:"PhD",name:"Loris",middleName:null,surname:"Nanni",slug:"loris-nanni",fullName:"Loris Nanni",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/494/images/system/494.jpg",biography:"Loris Nanni received his Master Degree cum laude on June-2002 from the University of Bologna, and the April 26th 2006 he received his Ph.D. in Computer Engineering at DEIS, University of Bologna. On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. His research interests include pattern recognition, bioinformatics, and biometric systems (fingerprint classification and recognition, signature verification, face recognition).",institutionString:null,institution:null},{id:"496",title:"Dr.",name:"Carlos",middleName:null,surname:"Leon",slug:"carlos-leon",fullName:"Carlos Leon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Seville",country:{name:"Spain"}}},{id:"512",title:"Dr.",name:"Dayang",middleName:null,surname:"Jawawi",slug:"dayang-jawawi",fullName:"Dayang Jawawi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Technology Malaysia",country:{name:"Malaysia"}}},{id:"528",title:"Dr.",name:"Kresimir",middleName:null,surname:"Delac",slug:"kresimir-delac",fullName:"Kresimir Delac",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/528/images/system/528.jpg",biography:"K. Delac received his B.Sc.E.E. degree in 2003 and is currentlypursuing a Ph.D. degree at the University of Zagreb, Faculty of Electrical Engineering andComputing. His current research interests are digital image analysis, pattern recognition andbiometrics.",institutionString:null,institution:{name:"University of Zagreb",country:{name:"Croatia"}}},{id:"557",title:"Dr.",name:"Andon",middleName:"Venelinov",surname:"Topalov",slug:"andon-topalov",fullName:"Andon Topalov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/557/images/1927_n.jpg",biography:"Dr. Andon V. Topalov received the MSc degree in Control Engineering from the Faculty of Information Systems, Technologies, and Automation at Moscow State University of Civil Engineering (MGGU) in 1979. He then received his PhD degree in Control Engineering from the Department of Automation and Remote Control at Moscow State Mining University (MGSU), Moscow, in 1984. From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. And he has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. His current research interests are in the fields of intelligent control and robotics.",institutionString:null,institution:{name:"Technical University of Sofia",country:{name:"Bulgaria"}}},{id:"585",title:"Prof.",name:"Munir",middleName:null,surname:"Merdan",slug:"munir-merdan",fullName:"Munir Merdan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/585/images/system/585.jpg",biography:"Munir Merdan received the M.Sc. degree in mechanical engineering from the Technical University of Sarajevo, Bosnia and Herzegovina, in 2001, and the Ph.D. degree in electrical engineering from the Vienna University of Technology, Vienna, Austria, in 2009.Since 2005, he has been at the Automation and Control Institute, Vienna University of Technology, where he is currently a Senior Researcher. His research interests include the application of agent technology for achieving agile control in the manufacturing environment.",institutionString:null,institution:null},{id:"605",title:"Prof",name:"Dil",middleName:null,surname:"Hussain",slug:"dil-hussain",fullName:"Dil Hussain",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/605/images/system/605.jpg",biography:"Dr. Dil Muhammad Akbar Hussain is a professor of Electronics Engineering & Computer Science at the Department of Energy Technology, Aalborg University Denmark. Professor Akbar has a Master degree in Digital Electronics from Govt. College University, Lahore Pakistan and a P-hD degree in Control Engineering from the School of Engineering and Applied Sciences, University of Sussex United Kingdom. Aalborg University has Two Satellite Campuses, one in Copenhagen (Aalborg University Copenhagen) and the other in Esbjerg (Aalborg University Esbjerg).\n· He is a member of prestigious IEEE (Institute of Electrical and Electronics Engineers), and IAENG (International Association of Engineers) organizations. \n· He is the chief Editor of the Journal of Software Engineering.\n· He is the member of the Editorial Board of International Journal of Computer Science and Software Technology (IJCSST) and International Journal of Computer Engineering and Information Technology. \n· He is also the Editor of Communication in Computer and Information Science CCIS-20 by Springer.\n· Reviewer For Many Conferences\nHe is the lead person in making collaboration agreements between Aalborg University and many universities of Pakistan, for which the MOU’s (Memorandum of Understanding) have been signed.\nProfessor Akbar is working in Academia since 1990, he started his career as a Lab demonstrator/TA at the University of Sussex. After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. 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It is also the time that lasts the development of the follicle in the ovary, until rupture occurs and ovulation takes place, which coincides with the appearance of estrus. This chapter will describe the physiological and endocrinological bases of estrus in the goat. Likewise, factors affecting the presence of estrus and ovulation will be described. At another point, synchronization of estrus and ovulation, factors affecting the presence of estrus and external symptoms of estrus, will be described. To achieve synchronization of estrus or induction of ovulation within or outside the breeding season, it may be necessary to manage light hours, male effect, and/or use of hormones. The importance of artificial insemination is described, as well as the current situation of this technique worldwide. Currently, the techniques of artificial insemination in goats have been limited worldwide, due to the lack of resources of producers and trained technicians. The techniques of artificial insemination with estrous synchronization programs and ovulation with current research results will be described.",book:{id:"5987",slug:"goat-science",title:"Goat Science",fullTitle:"Goat Science"},signatures:"Fernando Sánchez Dávila, Alejandro Sergio del Bosque González\nand Hugo Bernal Barragán",authors:[{id:"201830",title:"Dr.",name:"Fernando",middleName:"Sanchez",surname:"Davila",slug:"fernando-davila",fullName:"Fernando Davila"},{id:"206127",title:"Dr.",name:"Alejandro Sergio",middleName:null,surname:"Del Bosque-Gonzalez",slug:"alejandro-sergio-del-bosque-gonzalez",fullName:"Alejandro Sergio Del Bosque-Gonzalez"},{id:"206128",title:"Dr.",name:"Hugo",middleName:null,surname:"Bernal-Barragán",slug:"hugo-bernal-barragan",fullName:"Hugo Bernal-Barragán"}]},{id:"58095",title:"The Innovative Techniques in Animal Husbandry",slug:"the-innovative-techniques-in-animal-husbandry",totalDownloads:3766,totalCrossrefCites:4,totalDimensionsCites:8,abstract:"Technology is developing rapidly. In this development, the transfer of computer systems and software to the application has made an important contribution. Technologic instruments made farmers can work more comfortable and increased animal production efficiency and profitability. Therefore, technologic developments are the main research area for animal productivity and sustainability. Many technologic equipment and tools made animal husbandry easier and comfortable. Especially management decisions and applications are effected highly ratio with this rapid development. In animal husbandry management decisions that need to be done daily are configured according to the correctness of the decisions to be made. At this point, smart systems give many opportunities to farmers. Milking, feeding, environmental control, reproductive performance constitute everyday jobs most affected by correct management decisions. Human errors in this works and decisions made big effect on last product quality and profitability are not able to be risked. This chapter deal with valuable information on the latest challenges and key innovations affecting the animal husbandry. Also, innovative approaches and applications for animal husbandry are tried to be summarized with detail latest research results.",book:{id:"6384",slug:"animal-husbandry-and-nutrition",title:"Animal Husbandry and Nutrition",fullTitle:"Animal Husbandry and Nutrition"},signatures:"Serap Göncü and Cahit Güngör",authors:[{id:"215579",title:"Prof.",name:"Serap",middleName:null,surname:"Goncu",slug:"serap-goncu",fullName:"Serap Goncu"},{id:"218971",title:"Dr.",name:"Cahit",middleName:null,surname:"Güngör",slug:"cahit-gungor",fullName:"Cahit Güngör"}]},{id:"58486",title:"Quality of Chicken Meat",slug:"quality-of-chicken-meat",totalDownloads:3290,totalCrossrefCites:18,totalDimensionsCites:26,abstract:"Chicken meat is considered as an easily available source of high-quality protein and other nutrients that are necessary for proper body functioning. In order to meet the consumers’ growing demands for high-quality protein, the poultry industry focused on selection of fast-growing broilers, which reach a body mass of about 2.5 kg within 6-week-intensive fattening. Relatively low sales prices of chicken meat, in comparison to other types of meat, speak in favor of the increased chicken meat consumption. In addition, chicken meat is known by its nutritional quality, as it contains significant amount of high-quality and easily digestible protein and a low portion of saturated fat. Therefore, chicken meat is recommended for consumption by all age groups. The technological parameters of chicken meat quality are related to various factors (keeping conditions, feeding treatment, feed composition, transport, stress before slaughter, etc.). Composition of chicken meat can be influenced through modification of chicken feed composition (addition of different types of oils, vitamins, microelements and amino acids), to produce meat enriched with functional ingredients (n-3 PUFA, carnosine, selenium and vitamin E). By this way, chicken meat becomes a foodstuff with added value, which, in addition to high-quality nutritional composition, also contains ingredients that are beneficial to human health.",book:{id:"6384",slug:"animal-husbandry-and-nutrition",title:"Animal Husbandry and Nutrition",fullTitle:"Animal Husbandry and Nutrition"},signatures:"Gordana Kralik, Zlata Kralik, Manuela Grčević and Danica Hanžek",authors:[{id:"207236",title:"Dr.",name:"Gordana",middleName:null,surname:"Kralik",slug:"gordana-kralik",fullName:"Gordana Kralik"},{id:"227281",title:"Prof.",name:"Zlata",middleName:null,surname:"Kralik",slug:"zlata-kralik",fullName:"Zlata Kralik"},{id:"227283",title:"Dr.",name:"Manuela",middleName:null,surname:"Grčević",slug:"manuela-grcevic",fullName:"Manuela Grčević"},{id:"227284",title:"BSc.",name:"Danica",middleName:null,surname:"Hanžek",slug:"danica-hanzek",fullName:"Danica Hanžek"}]},{id:"56453",title:"Goat System Productions: Advantages and Disadvantages to the Animal, Environment and Farmer",slug:"goat-system-productions-advantages-and-disadvantages-to-the-animal-environment-and-farmer",totalDownloads:4328,totalCrossrefCites:5,totalDimensionsCites:21,abstract:"Goats have always been considered very useful animals. Goats success is related to its excellent adaptability to the difficult mountain conditions, extreme weather and low value feed acceptance, versatile habits and high production considering their size. These are some reasons because goats are among the first animals to be domesticated. In terms of evolution, goats could be separated by their dispersion area in three large groups: the European, the Asian, and the African. Global goat populations, mainly in Africa and in Asia, have increased for centuries but very strongly in the past decades, well above the world population growth. They are also used for forest grazing, an integrated and alternative production system, very useful to control weed growth reducing fire risk. Despite some exceptions, no large‐scale effort to professionalize this industry has been made so far. There are consumers for goat dairy products and there is enough global production, but misses a professional network between both. Regarding goat meat, the world leadership also stays in Africa and Asia, namely in China, and there is a new phenomenon, the spreading of goat meat tradition through Europe due to migrants from Africa and other places with strong goat meat consumption.",book:{id:"5987",slug:"goat-science",title:"Goat Science",fullTitle:"Goat Science"},signatures:"António Monteiro, José Manuel Costa and Maria João Lima",authors:[{id:"190314",title:"Prof.",name:"António",middleName:"Cardoso",surname:"Monteiro",slug:"antonio-monteiro",fullName:"António Monteiro"},{id:"203680",title:"Prof.",name:"Maria João",middleName:null,surname:"Lima",slug:"maria-joao-lima",fullName:"Maria João Lima"},{id:"203683",title:"MSc.",name:"José Manuel",middleName:null,surname:"Costa",slug:"jose-manuel-costa",fullName:"José Manuel Costa"}]},{id:"70760",title:"Induction and Synchronization of Estrus",slug:"induction-and-synchronization-of-estrus",totalDownloads:1716,totalCrossrefCites:1,totalDimensionsCites:2,abstract:"Estrus cycle is a rhythmic change that occur in the reproductive system of females starting from one estrus phase to another. The normal duration of estrus cycle is 21 days in cow, sow, and mare, 17 days in ewe, and 20 days in doe. The species which exhibit a single estrus cycle are known as monstrous and species which come into estrus twice or more are termed polyestrous animals. Among them some species have estrus cycles in a particular season and defined as seasonal polyestrous. It includes goats, sheep, and horses. On the other hand, cattle undergo estrus throughout the year. The estrus inducers can grossly be divided into two parts, that is, non-hormonal and hormonal. Non-hormonal treatments include plant-derived heat inducers, mineral supplementation, uterine and ovarian massage, and use of Lugol’s iodine. The hormones that are used in estrus induction are estrogen, progesterone, GnRH, prostaglandin, insulin, and anti-prolactin-based treatment. Synchronization can shorten the breeding period to less than 5 days, instead of females being bred over a 21-day period, depending on the treatment regimen. The combination of GnRH with the prostaglandin F2α (PGF2α)- and progesterone-based synchronization program has shown a novel direction in the estrus synchronization of cattle with the follicular development manipulation.",book:{id:"8545",slug:"animal-reproduction-in-veterinary-medicine",title:"Animal Reproduction in Veterinary Medicine",fullTitle:"Animal Reproduction in Veterinary Medicine"},signatures:"Prasanna Pal and Mohammad Rayees Dar",authors:[{id:"299126",title:"Dr.",name:"Mohammad Rayees",middleName:null,surname:"Dar",slug:"mohammad-rayees-dar",fullName:"Mohammad Rayees Dar"},{id:"311663",title:"Dr.",name:"Prasanna",middleName:null,surname:"Pal",slug:"prasanna-pal",fullName:"Prasanna Pal"}]}],onlineFirstChaptersFilter:{topicId:"25",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"82285",title:"Parvovirus Vectors: The Future of Gene Therapy",slug:"parvovirus-vectors-the-future-of-gene-therapy",totalDownloads:4,totalDimensionsCites:0,doi:"10.5772/intechopen.105085",abstract:"The unique diversity of parvoviral vectors with innate antioncogenic properties, autonomous replication, ease of recombinant vector production and stable transgene expression in target cells makes them an attractive choice as viral vectors for gene therapy protocols. Amongst various parvoviruses that have been identified so far, recombinant vectors originating from adeno-associated virus, minute virus of mice (MVM), LuIII and parvovirus H1 have shown promising results in many preclinical models of human diseases including cancer. The adeno-associated virus (AAV), a non-pathogenic human parvovirus, has gained attention as a potentially useful vector. The improved understanding of the metabolism of vector genomes and the mechanism of transduction by AAV vectors is leading to advancement in the development of more sophisticated AAV vectors. The in-depth studies of AAV vector biology is opening avenues for more robust design of AAV vectors that have potentially increased transduction efficiency, increased specificity in cellular targeting, and an increased payload capacity. This chapter gives an overview of the application of autonomous parvoviral vectors and AAV vectors, based on our current understanding of viral biology and the state of the platform.",book:{id:"11580",title:"Recent Advances in Canine Medicine",coverURL:"https://cdn.intechopen.com/books/images_new/11580.jpg"},signatures:"Megha Gupta"},{id:"81793",title:"Canine parvovirus-2: An Emerging Threat to Young Pets",slug:"canine-parvovirus-2-an-emerging-threat-to-young-pets",totalDownloads:15,totalDimensionsCites:0,doi:"10.5772/intechopen.104846",abstract:"Canine parvovirus-2 (CPV-2) is a highly contagious and key enteropathogen affecting the canine population around the globe by causing canine parvoviral enteritis (CPVE) and vomition. CPVE is one of the the leading causes of morbidity and mortality in puppies and young dogs. Over the years, five distinct antigenic variants of CPV-2, namely CPV-2a, CPV-2b, new CPV-2a, new CPV-2b, and CPV-2c, have emerged throughout the world. CPV-2 infects a diverse range of wild animals, and the newer variants of CPV-2 have expanded their host range to include felines. Despite the availability of highly specific diagnostics and efficacious vaccines, CPV-2 outbreaks have been reported globally due to the emergence of newer antigenic variants, expansion of the viral host range, and vaccination failures. The present chapter describes the latest information pertaining to virus properties and replication, disease manifestations in animals, and an additional recent updates on diagnostic, prevention and control strategies of CPV-2.",book:{id:"11580",title:"Recent Advances in Canine Medicine",coverURL:"https://cdn.intechopen.com/books/images_new/11580.jpg"},signatures:"Mithilesh Singh, Rajendran Manikandan, Ujjwal Kumar De, Vishal Chander, Babul Rudra Paul, Saravanan Ramakrishnan and Darshini Maramreddy"},{id:"81271",title:"The Diversity of Parvovirus Telomeres",slug:"the-diversity-of-parvovirus-telomeres",totalDownloads:38,totalDimensionsCites:0,doi:"10.5772/intechopen.102684",abstract:"Parvoviridae are small viruses composed of a 4–6 kb linear single-stranded DNA protected by an icosahedral capsid. The viral genes coding non-structural (NS), capsid, and accessory proteins are flanked by intriguing sequences, namely the telomeres. Telomeres are essential for parvovirus genome replication, encapsidation, and integration. Similar (homotelomeric) or different (heterotelomeric) at the two ends, they all contain imperfect palindromes that fold into hairpin structures. Up to 550 nucleotides in length, they harbor a wide variety of motifs and structures known to be recognized by host cell factors. Our study aims to comprehensively analyze parvovirus ends to better understand the role of these particular sequences in the virus life cycle. Forty Parvoviridae terminal repeats (TR) were publicly available in databases. The folding and specific DNA secondary structures, such as G4 and triplex, were systematically analyzed. A principal component analysis was carried out from the prediction data to determine variables signing parvovirus groups. A special focus will be put on adeno-associated virus (AAV) inverted terminal repeats (ITR), a member of the genus Dependoparvovirus used as vectors for gene therapy. This chapter highlights the diversity of the Parvoviridae telomeres regarding shape and secondary structures, providing information that could be relevant for virus-host interactions studies.",book:{id:"11580",title:"Recent Advances in Canine Medicine",coverURL:"https://cdn.intechopen.com/books/images_new/11580.jpg"},signatures:"Marianne Laugel, Emilie Lecomte, Eduard Ayuso, Oumeya Adjali, Mathieu Mével and Magalie Penaud-Budloo"},{id:"79209",title:"Virtual Physiology: A Tool for the 21st Century",slug:"virtual-physiology-a-tool-for-the-21st-century",totalDownloads:151,totalDimensionsCites:0,doi:"10.5772/intechopen.99671",abstract:"Veterinary physiology is a basic curricular unit for every course within the veterinary field. It is mandatory to understand how the animal body works, and what to expect of a healthy body, in order to recognize any misfunction, and to be able to treat it. Classic physiology teaching involves wet labs, much equipment, many reagents, some animals, and a lot of time. But times are changing. In the 21st century, it is expected that the teaching and learning process can be more active and attractive, motivating students to learn better. It is necessary to understand what students like, and to introduce novelties into the school routine. The use of a game-based learning, using “new” technologies, creating virtual experiences and labs, reducing the costs of reagents, equipment, and especially reducing the use of animals, will be the future for physiology teaching.",book:{id:"10665",title:"Updates on Veterinary Anatomy and Physiology",coverURL:"https://cdn.intechopen.com/books/images_new/10665.jpg"},signatures:"Carmen Nóbrega, Maria Aires Pereira, Catarina Coelho, Isabel Brás, Ana Cristina Mega, Carla Santos, Fernando Esteves, Rita Cruz, Ana I. Faustino-Rocha, Paula A. Oliveira, João Mesquita and Helena Vala"},{id:"78543",title:"Pulmonary Vein: Embryology, Anatomy, Function and Disease",slug:"pulmonary-vein-embryology-anatomy-function-and-disease",totalDownloads:182,totalDimensionsCites:0,doi:"10.5772/intechopen.100051",abstract:"Four pulmonary veins come from respective lung lobes drain oxygen-rich blood back to the left atrium. Failure of incorporation with the left atrium can lead to a condition, called Cor triatriatum sinister, that the left atrium is separated into two chambers by an abortive fibrous tissue. The venous system of lung and whole body communicate with each other in the earlier time and they will be disconnected in the following developmental process. Total or partial anomalous pulmonary venous connection refers to that there is/are some degree of the communication exists after birth, which can occur in different sites. In the veterinary field, retrospective studies and several case reports have been published to describe these rare congenital cardiovascular diseases in several species. More cases are need for better understanding their clinical manifestation, treatment options and outcomes.",book:{id:"10665",title:"Updates on Veterinary Anatomy and Physiology",coverURL:"https://cdn.intechopen.com/books/images_new/10665.jpg"},signatures:"Chan I-Ping and Hsueh Tung"},{id:"78564",title:"Anatomy of the Rhesus Monkey (Macaca mulatta): The Essentials for the Biomedical Researcher",slug:"anatomy-of-the-rhesus-monkey-macaca-mulatta-the-essentials-for-the-biomedical-researcher",totalDownloads:345,totalDimensionsCites:0,doi:"10.5772/intechopen.99067",abstract:"Amongst the non-human primates, the rhesus monkey (Macaca mulatta) is the most commonly investigated species in biomedical research. Its similarity to humans regarding the anatomy and physiology has resulted in an increasing number of studies in which the rhesus monkey serves as a model. This book chapter aims to fulfill the researcher’s need for easily accessible anatomical data on the rhesus monkey by presenting the essentials of its various anatomical systems. The cadavers of several rhesus monkeys of either gender were dissected for gross anatomical study of the muscular, digestive, respiratory and urogenital systems. The circulatory system was studied after injection of latex into the blood vessels. Not only did this technique allow for better visualization of the blood vessels, but it was also valuable during the description of the peripheral nerves. In addition, methyl methacrylate casts were prepared to gain insight into the organization of the arterial system. The arthrology of the rhesus monkey was studied during the maceration of several cadavers, which ultimately revealed the individual bones that were described. From one such cadaver the skeleton was mounted. The results of the dissections are textually described and illustrated by means of numerous figures.",book:{id:"10665",title:"Updates on Veterinary Anatomy and Physiology",coverURL:"https://cdn.intechopen.com/books/images_new/10665.jpg"},signatures:"Christophe Casteleyn and Jaco Bakker"}],onlineFirstChaptersTotal:12},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:89,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:31,numberOfPublishedChapters:314,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:11,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:105,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:18,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:5,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:14,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. This Biochemistry Series will address the current research on biomolecules and the emerging trends with great promise.",coverUrl:"https://cdn.intechopen.com/series/covers/11.jpg",latestPublicationDate:"June 24th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:31,editor:{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",slug:"miroslav-blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:4,paginationItems:[{id:"14",title:"Cell and Molecular Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",isOpenForSubmission:!0,editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",slug:"rosa-maria-martinez-espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",biography:"Dr. Rosa María Martínez-Espinosa has been a Spanish Full Professor since 2020 (Biochemistry and Molecular Biology) and is currently Vice-President of International Relations and Cooperation development and leader of the research group 'Applied Biochemistry” (University of Alicante, Spain). Other positions she has held at the university include Vice-Dean of Master Programs, Vice-Dean of the Degree in Biology and Vice-Dean for Mobility and Enterprise and Engagement at the Faculty of Science (University of Alicante). She received her Bachelor in Biology in 1998 (University of Alicante) and her PhD in 2003 (Biochemistry, University of Alicante). She undertook post-doctoral research at the University of East Anglia (Norwich, U.K. 2004-2005; 2007-2008).\nHer multidisciplinary research focuses on investigating archaea and their potential applications in biotechnology. She has an H-index of 21. She has authored one patent and has published more than 70 indexed papers and around 60 book chapters.\nShe has contributed to more than 150 national and international meetings during the last 15 years. Her research interests include archaea metabolism, enzymes purification and characterization, gene regulation, carotenoids and bioplastics production, antioxidant\ncompounds, waste water treatments, and brines bioremediation.\nRosa María’s other roles include editorial board member for several journals related\nto biochemistry, reviewer for more than 60 journals (biochemistry, molecular biology, biotechnology, chemistry and microbiology) and president of several organizing committees in international meetings related to the N-cycle or respiratory processes.",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"15",title:"Chemical Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",isOpenForSubmission:!0,editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",slug:"sukru-beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",biography:"Dr. Şükrü Beydemir obtained a BSc in Chemistry in 1995 from Yüzüncü Yıl University, MSc in Biochemistry in 1998, and PhD in Biochemistry in 2002 from Atatürk University, Turkey. He performed post-doctoral studies at Max-Planck Institute, Germany, and University of Florence, Italy in addition to making several scientific visits abroad. He currently works as a Full Professor of Biochemistry in the Faculty of Pharmacy, Anadolu University, Turkey. Dr. Beydemir has published over a hundred scientific papers spanning protein biochemistry, enzymology and medicinal chemistry, reviews, book chapters and presented several conferences to scientists worldwide. He has received numerous publication awards from various international scientific councils. He serves in the Editorial Board of several international journals. Dr. Beydemir is also Rector of Bilecik Şeyh Edebali University, Turkey.",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",slug:"deniz-ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",biography:"Dr. Deniz Ekinci obtained a BSc in Chemistry in 2004, MSc in Biochemistry in 2006, and PhD in Biochemistry in 2009 from Atatürk University, Turkey. He studied at Stetson University, USA, in 2007-2008 and at the Max Planck Institute of Molecular Cell Biology and Genetics, Germany, in 2009-2010. Dr. Ekinci currently works as a Full Professor of Biochemistry in the Faculty of Agriculture and is the Head of the Enzyme and Microbial Biotechnology Division, Ondokuz Mayıs University, Turkey. He is a member of the Turkish Biochemical Society, American Chemical Society, and German Genetics society. Dr. Ekinci published around ninety scientific papers, reviews and book chapters, and presented several conferences to scientists. He has received numerous publication awards from several scientific councils. Dr. Ekinci serves as the Editor in Chief of four international books and is involved in the Editorial Board of several international journals.",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null},{id:"17",title:"Metabolism",coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",isOpenForSubmission:!0,editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",slug:"yannis-karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",biography:"Yannis Karamanos, born in Greece in 1953, completed his pre-graduate studies at the Université Pierre et Marie Curie, Paris, then his Masters and Doctoral degree at the Université de Lille (1983). He was associate professor at the University of Limoges (1987) before becoming full professor of biochemistry at the Université d’Artois (1996). He worked on the structure-function relationships of glycoconjugates and his main project was the investigations on the biological roles of the de-N-glycosylation enzymes (Endo-N-acetyl-β-D-glucosaminidase and peptide-N4-(N-acetyl-β-glucosaminyl) asparagine amidase). From 2002 he contributes to the understanding of the Blood-brain barrier functioning using proteomics approaches. He has published more than 70 papers. 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Since then, he has been working as an Adjunct Professor in the same Department at the University of Pavia. His research activity during the first years was primarily focused on the purification and structural characterization of enzymes from animal and plant sources. During this period, Prof. Iadarola familiarized himself with the conventional techniques used in column chromatography, spectrophotometry, manual Edman degradation, and electrophoresis). Since 1995, he has been working on: i) the determination in biological fluids (serum, urine, bronchoalveolar lavage, sputum) of proteolytic activities involved in the degradation processes of connective tissue matrix, and ii) on the identification of biological markers of lung diseases. In this context, he has developed and validated new methodologies (e.g., Capillary Electrophoresis coupled to Laser-Induced Fluorescence, CE-LIF) whose application enabled him to determine both the amounts of biochemical markers (Desmosines) in urine/serum of patients affected by Chronic Obstructive Pulmonary Disease (COPD) and the activity of proteolytic enzymes (Human Neutrophil Elastase, Cathepsin G, Pseudomonas aeruginosa elastase) in sputa of these patients. More recently, Prof. Iadarola was involved in developing techniques such as two-dimensional electrophoresis coupled to liquid chromatography/mass spectrometry (2DE-LC/MS) for the proteomic analysis of biological fluids aimed at the identification of potential biomarkers of different lung diseases. He is the author of about 150 publications (According to Scopus: H-Index: 23; Total citations: 1568- According to WOS: H-Index: 20; Total Citations: 1296) of peer-reviewed international journals. 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She gained considerable experience in developing and validating new methodologies whose applications allowed her to determine both the amount of biomarkers (Desmosine and Isodesmosine) in the urine of patients affected by COPD, and the activity of proteolytic enzymes (HNE, Cathepsin G, Pseudomonas aeruginosa elastase) in the sputa of these patients. Simona Viglio was also involved in research dealing with the supplementation of amino acids in patients with brain injury and chronic heart failure. She is presently engaged in the development of 2-DE and LC-MS techniques for the study of proteomics in biological fluids. The aim of this research is the identification of potential biomarkers of lung diseases. 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