\r\n\tHence, this book is targeted to deliver the bundled characteristics and features of MXenes to transfer the various scopes and virtues to the research community.
",isbn:"978-1-83768-120-4",printIsbn:"978-1-83768-119-8",pdfIsbn:"978-1-83768-121-1",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,isNomenclature:!1,hash:"184e1a0c9b5e62ebb3c7ebc53103db9f",bookSignature:"Prof. Dhanasekaran Vikraman",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11994.jpg",keywords:"Energy Devices, Semiconducting Devices, MXene Formulation, Supercapacitors, Batteries, Water Electrolysis, Li-Ion, FET, Photodetectors, Solar Cells, Perovskites, W2C",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"May 19th 2022",dateEndSecondStepPublish:"June 16th 2022",dateEndThirdStepPublish:"August 15th 2022",dateEndFourthStepPublish:"November 3rd 2022",dateEndFifthStepPublish:"January 2nd 2023",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"20 days",secondStepPassed:!1,areRegistrationsClosed:!1,currentStepOfPublishingProcess:2,editedByType:null,kuFlag:!1,biosketch:"Dr. Dhanasekaran Vikraman is an Assistant Professor at Dongguk University-Seoul, Seoul, Korea. 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After that, he completed his Master's and Ph.D. degrees at the Department of Physics, Alagappa University, India. Later, he received a visiting scientist position at KIST, Korea; a Marie-Curie Experienced Researcher fellowship at the Department of Physics, Aristotle University of Thessaloniki, Greece; and Post-Doc positions at Sejong University and Ajou University, Korea. He has authored more than 175 international journal articles and 3 book chapters. He is serving as a Guest Editor and topic Editor for various journals. 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\n
1. Introduction
\n
Holography [1–4] is a technique to record a wavefront of an object wave by utilizing interference of light as well as reconstruct a three-dimensional (3D) image of an object. The medium containing the information of an interference fringe image is called a “hologram”, which contains both the amplitude and phase information of an object wave. 3D image information is reconstructed using a hologram and diffraction theory. One of the most remarkable features in holography is that 3D motion-picture recording of any ultrafast physical phenomenon can be achieved, even for light propagation in 3D space [3]. Digital holography [5–8] is a technique to record a hologram digitally using an image sensor, and reconstruct both the 3D and quantitative phase images of an object using a computer or spatial light modulator. This technique has been researched for not only the observation of ultrafast phenomenon, but also for microscopy [9, 10], quantitative phase imaging [11, 12], and multimodal imaging [13, 14].
\n
In recent years, there has been an increase in demand for multispectral imaging techniques. Multiwavelength information helps us to perceive, analyze, and recognize an object such as body tissue or a tumor. Wavelength of light has the ability to clarify color and material distributions of an object [15], visualize the localization and dynamics of molecules with Raman scattering [16, 17], and analyze the health of human skin [18]. In digital holography, the information of multiple wavelengths and 3D space is obtained by recording waves with multiple wavelengths that are irradiated from light sources, called multiwavelength/color digital holography [19, 20]. Multiwavelength digital holography has the ability for not only color 3D imaging [19, 20], but also dispersion imaging [21] and 3D shape measurement with a wide range by using multiwavelength phase unwrapping [22], due to the recording of quantitative phase information with multiple wavelengths. Temporal division [23–25], spatial division [26–28], and space-division multiplexing [19, 20, 29], which are generally adopted for multiwavelength imaging in an imaging system, can be merged into digital holography to record multiple wavelengths. In general imaging systems, wavelength information is temporally or spatially separated when recording image(s), as shown in \nFigure 1(a)\n–\n(e)\n. However, holographic techniques make it possible to record multiwavelength/color information using a monochromatic image sensor and to reconstruct it from wavelength-multiplexed image(s). In holography, multiple wavelength information is obtained also by utilizing temporal frequency-division multiplexing (\nFigure 1(f)\n) [30, 31] and spatial frequency-division multiplexing (\nFigure 1(g)\n) [32, 33]. In these techniques, Fourier and inverse Fourier transforms are required to separate wavelength information. In the former, many wavelength-multiplexed images and an image sensor with a high frame rate are needed. In the latter, the spatial bandwidth available for recording an object wave at a wavelength is restricted as the number of wavelengths is increased.
\n
Figure 1.
Multiwavelength imaging systems. (a) Temporal division, spatial division with (b) multiple image sensors and a prism and (c) a stacked image sensor, space-division multiplexing with (d) a color image sensor and (e) a grating, (f) temporal frequency-division multiplexing, and (g) spatial frequency-division multiplexing.
\n
Since 2013, we have presented a novel multiwavelength imaging technique utilizing holography and wavelength-multiplexed images [34–39]. The presented technique gives phase-shifting interferometry [40–51] the function to extract wavelength information such as wavelength dependencies of amplitude, phase, and polarization state selectively from wavelength-multiplexed phase-shifted holograms. It is especially important to record not only phase images but also amplitude distributions of object waves at multiple wavelengths in order to achieve multicolor and multispectral 3D imaging of multiple objects. By making use of holography for multiwavelength imaging, 3D space information is simultaneously captured. In this chapter, we explain the proposed technique, phase-shifting interferometry selectively extracting wavelength information: phase-division multiplexing (PDM) of multiple wavelengths and two-step phase-shifting interferometry-merged phase-division multiplexing (2π-PDM).
\n\nFigure 2\n illustrates the schematic of the proposed multiwavelength 3D imaging technique in the case where the number of wavelengths N is two, which was initially presented in 2013 [34–36]. Optical setup is based on phase-shifting digital holography with multiple lasers. Multiple object and reference waves with multiple wavelengths illuminate a monochromatic image sensor simultaneously. The sensor records wavelength-multiplexed phase-shifted holograms I(x,y:α\n1,α\n2) by changing the phases of the reference waves. Phase shifts for respective wavelengths α\n1 and α\n2 are introduced. An object wave at the desired wavelength is selectively extracted from the holograms by the signal processing based on phase-shifting interferometry. As a result, a color 3D image is reconstructed from the selectively extracted object waves. Thus, color 3D imaging can be achieved with grayscale wavelength-multiplexed images. When the number of wavelengths is N, 2N + 1 variables are contained in a wavelength-multiplexed hologram: the number N of object waves, N of conjugate images, and the sum of the 0th-order diffraction waves. Therefore, five holograms are required to solve the system of equations when N = 2. It is noted that no Fourier transform is essentially required.
\n
Figure 2.
Schematic representation of the proposed multiwavelength 3D imaging technique.
\n
\n\nFigure 3\n describes the principle that wavelength information is selectively extracted by the signal processing in the space domain. As seen in \nFigure 3\n, different phase shifts for respective wavelengths are given to object waves with multiple wavelengths, and then wavelength information is separated in the polar coordinate plane. Although this separation is used to extract an object wave from a hologram in general phase-shifting interferometry, in the proposed technique, the separation is utilized to remove not only the conjugate images and 0th-order diffraction wave, but also undesired wavelength information. This means phase-division multiplexing (PDM) of wavelengths. \nFigure 3\n shows the case where specific phase shifts are used [34–36], but this concept is also applicable to the case where arbitrary phase shifts are introduced [39].
\n
Figure 3.
Principle of phase-division multiplexing (PDM) of wavelengths: separation of multiple wavelengths in the polar coordinate plane.
\n
\n\nFigure 4\n illustrates optical implementations of the proposed digital holography. Multiple lasers irradiate laser beams with multiple wavelengths simultaneously. A device for shifting the phase of light, such as a mirror with a piezo actuator, a spatial light modulator, or wave plates, is placed in the path of the reference arm. A monochromatic image sensor records the required wavelength-multiplexed phase-shifted holograms sequentially. An optical system based on PDM has the following features: the spectroscopic sensitivity of the optical system can be extended in comparison to the system with a color image sensor; full space-bandwidth product of an image sensor can be used to record object waves with multiple wavelengths; a bright color image can be obtained due to no spectroscopic absorption, while wavelengths filters required in conventional systems absorb light to obtain a color image; and measurement time is shortened by the wavelength-multiplexed recording in comparison with temporal division technique.
\n
Figure 4.
Optical implementations of PDM. Optical setups with (a) a mirror with a piezo actuator and (b) a spatial light modulator that has wavelength dependency in phase modulation.
\n
\n\nFigure 5\n illustrates the image reconstruction algorithm [34–36]. A wavelength-multiplexed phase-shifted hologram I(x,y:α\n1,α\n2) is expressed as follows,
here I\n\nλ1(x,y:α\n1) and I\n\nλ2(x,y:α\n2) are holograms at the wavelengths of λ\n1 and λ\n2, respectively. Eq. (1) means that a recorded monochromatic image is the sum of I\n\nλ1(x,y:α\n1) and I\n\nλ2(x,y:α\n2). When the complex amplitude distributions of object waves with different wavelengths are U\n\nλ1(x,y) and U\n\nλ2(x,y), 0th(x,y) is the 0th-diffraction wave, Ar(x,y) is the amplitude distribution of the reference wave, j is imaginary unit, * means complex conjugate, and L and M are integers, then I(x,y:α\n1,α\n2) can be rewritten as follows,
Only the complex amplitude distributions of object waves with dual wavelengths U\n\nλ1(x,y) and U\n\nλ2(x,y) are derived from five wavelength-multiplexed phase-shifted holograms I(x,y:0,0), I(x,y:α\n1,α\n2), I(x,y:-α\n1,-α\n2), I(x,y:α\n3,α\n4), and I(x,y:-α\n3,-α\n4) because five variables are contained in Eq. (2). If the system shown in \nFigure 4(a)\n is used to implement the proposed technique by moving the mirror in the reference arm with a piezo actuator at a distance Z in the depth direction, the phase shifts are
Here, when Z is equal to Lλ\n1/2, α\n1 is 2πL and α\n2 is 2πLλ\n1/λ\n2. As a result, the intensity distribution I\n\nλ1(x,y: α\n1) is not changed and I\n\nλ2(x,y: α\n2) is changed, unless Lλ\n1/λ\n2 is an integer. In the case where an integral multiple of 2π is utilized for phase shifts, meaning α\n2 = 2πM and α\n3 = 2πL, U\n\nλ1(x,y) and U\n\nλ2(x,y) are separately derived by the following expressions.
As shown in Eqs. (5) and (6), subtraction between holograms, which is based on phase-shifting interferometry, is calculated and the unwanted wavelength component I\n\nλ1(x,y) or I\n\nλ2(x,y) is removed. Thus, dual-wavelength information is extracted selectively from five phase-shifted holograms. In this way, multiwavelength information can be separately extracted from 2N + 1 holograms when the number of wavelengths is N. From the extracted complex amplitude distributions on the image sensor plane, a multiwavelength 3D object image is reconstructed by the calculations of diffraction integrals and color synthesis.
\n
\n
\n
3. Numerical simulation
\n
Numerical simulations were conducted to verify the effectiveness of the proposed technique. \nFigure 6\n shows the amplitude and phase distributions of the object wave at each wavelength. As shown in \nFigure 6(b)\n, a color object with rough surface was assumed. 640 and 532 nm were assumed as the wavelengths of the light sources. Red and green color components of a standard image “pepper” were used as amplitude images at 640 and 532 nm, respectively. In these simulations, the distance between the object and image sensor was assumed as 200 mm, pixel pitch was 5 μm, resolution was 10 bits, and number of pixels was 512 × 512. \nFigure 7\n shows the images reconstructed by the proposed technique. Faithful images were reconstructed at each wavelength, and crosstalk between object waves with different wavelengths was not seen. The color synthesized image in \nFigure 7(c)\n indicates color 3D imaging ability. Thus, the validity of the proposed technique was numerically confirmed. Detailed numerical analyses and an experimental demonstration using an image sensor with 12-bit resolution were reported in Ref. [36].
\n
Figure 6.
Object wave for a numerical simulation. (a) Amplitude and (b) phase distributions of the object wave. Assumed amplitude images at the wavelengths of (c) 640 nm and (d) 532 nm.
\n
Figure 7.
Numerical results. Reconstructed images at the wavelengths of (a) 640 nm and (b) 532 nm. (c) Color synthesized image.
In a wavelength-multiplexed hologram, 2N + 1 variables are contained. Therefore, 2N + 1 images are needed to extract object waves separately in a general PDM technique. However, 2N wavelength-multiplexed holograms are sufficient to selectively extract object waves with N wavelengths, with the two-step phase-shifting interferometry-merged phase-division multiplexing (2π-PDM) technique [38]. \nFigure 8\n illustrates the basic concept of 2π-PDM. Two main points of 2π-PDM are the utilization of 2π ambiguity of the phase [34, 35] and merger of two-step phase-shifting interferometry [52–56]. As described in section 2, an intensity distribution at a wavelength is not changed when a phase shift is an integral multiple of 2π. We make the best use of this nature to decrease the required number of wavelength-multiplexed images. Also, merging PDM and two-step phase-shifting interferometry is important to satisfy high-quality multiwavelength 3D imaging and acceleration of a recording simultaneously. When recording three wavelengths, six holograms are sufficient with 2π-PDM, as described with an optical implementation in Ref. [38].
\n
Figure 8.
Basic concept of 2π-PDM.
\n
The optical setup required for 2π-PDM is the same as that for other PDM techniques. Therefore, the systems in \nFigure 4\n are applicable to 2π-PDM. In 2π-PDM, various types of two-step phase-shifting methods [52–56] can be employed. When merging Meng’s two-step method [53] into 2π-PDM, intensity distributions of reference waves Ir\n\nλ1(x,y) = Ar\n\nλ1\n2(x,y) and Ir\n\nλ2(x,y) = Ar\n\nλ2\n2(x,y) are sequentially recorded before the measurement by inserting a shutter in the path of the object arm. \nFigure 9\n describes an algorithm for selectively extracting wavelength information in 2π-PDM adopting Meng’s technique. In the case of N = 2, a monochromatic image sensor records four wavelength-multiplexed phase-shifted holograms I(x,y:0,0), I(x,y:α\n1,arb.), I(x,y:2πM,α\n2), and I(x,y:−2πM,−α\n2), and intensity distributions of reference waves Ir\n\nλ1(x,y) and Ir\n\nλ2(x,y). By making use of 2π ambiguity, both a 0th-order diffraction wave 0th\n\nλ2(x,y) and an intensity distribution of a hologram at an undesired wavelength I\n\nλ1(x,y) are removed simultaneously by the subtraction procedure. Therefore, an object wave U\n\nλ2(x,y) is extracted from three holograms, although five variables are contained in each hologram. In the case where α\n1 and α\n2 > 0, U\n\nλ2(x,y) is derived by
Algorithm for selectively extracting wavelength information in 2π-PDM.
\n
From the extracted object wave U\n\nλ2(x,y) and the amplitude distribution of the reference wave at λ\n2, the intensity distribution at only λ\n2 component I\n\nλ2(x,y:α\n2) is numerically generated by a computer,
If the sum of the intensities of the 0th-order diffraction waves is equal to |U\n\nλ1(x,y)|2 + Ir\n\nλ1(x,y) + |U\n\nλ2(x,y)|2 + Ir\n\nλ2(x,y), noiseless multiwavelength 3D imaging can be achieved with 2π-PDM adopting Meng’s two-step phase-shifting interferometry, according to the procedures described from here. By using the numerically generated images I\n\nλ2cal(x,y:0) and I\n\nλ2cal(x,y:arb.), intensity distributions at only λ\n1 component I\n\nλ1(x,y:0) and I\n\nλ1(x,y:α\n1) are obtained from I(x,y:0,0) and I(x,y:α\n1,arb.) as the following expressions:
From the obtained I\n\nλ1(x,y:0) and I\n\nλ1(x,y:α\n1) and amplitude distribution of the reference wave at λ\n1, the object wave at λ\n1U\n\nλ1(x,y) can be analytically extracted by using two-step phase-shifting interferometry.
Thus, the object waves at the desired wavelengths are extracted selectively from four wavelength-multiplexed phase-shifted holograms and intensity distributions of the reference waves. In this way, in the case where the number of wavelengths is N, multiwavelength information can be separately extracted from 2N holograms. By applying diffraction integrals to the object waves, amplitude and phase distributions of the object on the desired depth are reconstructed at multiple wavelengths. Therefore, a 3D image and wavelength dependency of the object can be obtained simultaneously.
\n
Note that an arbitrary phase shift at λ\n2 is allowable in one of the wavelength-multiplexed, phase-shifted, and monochromatic holograms I(x,y:α\n1,arb.) in a 2π-PDM algorithm described above. Therefore, 2π-PDM conducts asymmetric phase-shifting and belongs to partially generalized phase-shifting interferometry.
\n
\n
\n
5. Experimental demonstration of 2π-PDM
\n
We have demonstrated 2π-PDM experimentally to show color 3D imaging ability [38]. \nFigure 10\n shows a completed model of the optical system illustrated in \nFigure 4(a)\n. Four wavelength-multiplexed phase-shifted holograms were recorded sequentially by using a mirror with a piezo actuator. Before/after that, two intensity images of two reference waves were sequentially recorded only once. The wavelengths of the lasers were λ\n1 = 640 and λ\n2 = 473 nm. A monochromatic CMOS image sensor was used to record the holograms and reference intensities. The sensor has 12-bit resolution, 2592 × 1944 pixels, and the pixel pitch of 2.2 μm. The mirror with a piezo actuator moved Z = 0, 237, and ±320 nm sequentially to generate phase shifts that were required for 2π-PDM. Phase shifts (α\n1,α\n2) at (λ\n1,λ\n2) were (0,0), (2π(λ\n2/λ\n1), 2π), (2π, 2π(λ\n1/λ\n2)), and (−2π,−2π(λ\n1/λ\n2)). To investigate the phase shifts at their respective wavelengths, interference fringe patterns at the wavelengths were observed before the experimental demonstration, and details were explained in Ref. [38]. Two transparency sheets were set as a color 3D object. The logo of the International Year of Light (IYL) and the characters “2015” were printed on the sheets, and blue and red color films were attached to the logo and characters, respectively. The red “2015” sheet and blue logo sheet were set on the depths of 250 and 320 mm from the image sensor plane, respectively. Opaque sheets were also attached on blue and red color sheets to scatter the object illumination light. Therefore, the 3D color object had a rough surface and scattered object waves illuminated the image sensor. The object wave at the wavelength λ = 473 nm was extracted from three holograms and the object wave at λ = 640 nm was obtained by the procedures of Eqs. (7)–(15). For comparison, a colored object image was also reconstructed from a wavelength-multiplexed hologram.
\n
Figure 10.
Photograph of the constructed dual-wavelength optical system of 2π-PDM.
\n
\n\nFigure 11\n shows the experimental results. Wavelength-multiplexed monochromatic images such as \nFigure 11(a)\n were captured, and wavelength information was superimposed on space and spatial frequency domains as seen in \nFigure 11(a)\n and \n(b)\n. \nFigure 11(c)\n and \n(d)\n were the images focused digitally at a distance of 320 mm from the image sensor plane and reconstructed by diffraction integral alone and 2π-PDM, respectively. Blue and red color films attached to the sheets absorbed red and blue light, respectively. However, \nFigure 11(c)\n, which was obtained from a wavelength-multiplexed hologram, indicated the superimpositions of not only the 0th-order diffraction wave and the conjugate image but also image components given by the crosstalk between I\n\nλ1(x,y:α\n1) and I\n\nλ2(x,y:α\n2). As a result, color information was not retrieved adequately. In contrast, \nFigure 11(d)\n showed the removal of the unwanted images, the crosstalk components, and the successful experimental demonstration of clear color imaging by 2π-PDM. \nFigure 11(e)\n and \n(f)\n were the object images focused on 250 and 320 mm depths from the sensor plane, which were obtained by an image-reconstruction procedure of 2π-PDM. Thus, we validated 2π-PDM in the imaging of wavelength dependency of absorption for a 3D object and high-quality color 3D imaging ability.
\n
Figure 11.
Experimental results of 2π-PDM. (a) One of the recorded holograms and (b) its 2D Fourier transformed image. (c) Image reconstructed from the hologram of (a). (d) Whole image reconstructed by 2π-PDM. (c) and (d) are the images digitally focused on 250 mm depth from the image sensor plane. Object images numerically focused on (e) 250 mm and (f) 320 mm depths, which were reconstructed by 2π-PDM.
\n
\n
\n
6. Discussions and summary
\n
We have proposed phase-shifting interferometry selectively extracting wavelength information as a novel multiwavelength imaging technique. In this technique, not only multiwavelength images but also the information of 3D space are simultaneously captured by the combination with holography. The technique is characterized as phase-division multiplexing (PDM) of wavelengths, and wavelength information is separately extracted in the space domain from the information of multiple wavelength-multiplexed images. 2π-PDM is the technique to analytically and completely solve the system of equations with 2N holograms against 2N + 1 variables contained in each hologram. An experimental demonstration was conducted and clear color 3D imaging ability was successfully shown. Note that detailed analyses against both the experimental demonstration and the theory in 2π-PDM were reported in Ref. [38].
\n
As future works, constructions of three-color digital holography and multidimensional holography systems are important to realize full-color 3D imaging and multidimensional holographic sensing. \nFigure 12\n shows an example of the required holograms in three-wavelength 2π-PDM [38] and numerical results for theoretical validation. Phase shifts indicated in \nFigure 12(a)\n mean that three-color 3D imaging with 2π-PDM is capable, when a spatial light modulator or wave plates are used as phase shifter(s) as described in Ref. [38]. Also, a combination of a piezo and a wave plate or a spatial light modulator will be applicable as another implementation. \nFigure 12(b)\n–\n(i)\n shows the results of a numerical simulation for three-wavelength 2π-PDM. In this simulation, a three-color object “pepper” with a smooth surface shape, red, green, and blue color wavelengths of 640, 532, and 473 nm, and 200 mm distance between image sensor and object planes, an image sensor with the pixel pitch of 5 μm, 512 × 512 pixels, ideal bit resolution, and α\n1, α\n2, α\n3 = π/2 were assumed. These assumptions can be satisfied with the optical system with five quarter wave plates, which is illustrated in Ref. [38]. Numerical results indicate that multiwavelength holographic 3D imaging can be done with high image quality from grayscale wavelength-multiplexed images, if successfully constructed. Improvements on the measurement principle and/or an image-reconstruction algorithm are important to simplify the construction; this is one of the main issues to be solved. From the viewpoint of multidimensional holographic imaging, PDM and 2π-PDM have the potential for not only multiwavelength, but also polarization-imaging digital holography [37] and instantaneous measurement [35], as implementations are described in these references. It is expected that simultaneous imaging of 3D structures, multiple wavelengths, and polarization distribution can be demonstrated with 2π-PDM.
\n
Figure 12.
(a) An example of holograms required for three-wavelength 2π-PDM and (b)–(i) its numerical results. (b) Amplitude and (c) phase distributions of the assumed object wave and (d) one of three-wavelength-multiplexed phase-shifted holograms. Reconstructed amplitude images at the wavelengths of (e) 640 nm, (f) 532 nm, (g) 473 nm, and (h) phase image at 640 nm. (i) Color synthesized image obtained from (d)–(f). In the results, wave plates are assumed as phase shifters as described in Ref. [38]. The image-reconstruction procedure is in the same manner of dual-wavelength 2π-PDM, which is explained in Section 4.
\n
The next step of the PDM techniques is the extension to multicolor holographic 3D image sensing, simultaneous imaging of color and 3D shape with multiwavelength phase unwrapping, dispersion imaging of a 3D specimen, and multidimensional holographic imaging. This technique has prospective applications to multispectral microscopy to observe 3D specimens with a wide field of view, quantitative phase imaging, multicolor lensless 3D camera, multidimensional holographic image sensors, and other multiwavelength 3D imaging applications.
\n
\n
Acknowledgments
\n
We appreciate Kris Cutsail-Numata for checking the English grammar in this chapter of the book. One of the authors would like to sincerely thank Shu Tahara for encouragement. This research was supported by Japan Science and Technology Agency (JST), PRESTO, Konica Minolta Science and Technology Foundation, The Okawa Foundation, Research Foundation of Tokyo Institute of Technology, the Japan Society for the Promotion of Science (JSPS), MEXT-Supported Program for the Strategic Research Foundation at Private Universities (from 2013 to 2018), and Research Foundation for Opt-Science and Technology.
\n
\n',keywords:"digital holography, holography, interferometry, holographic interferometry, phase-shifting interferometry, multiwavelength interferometry, color holography, multiwavelength 3D imaging, color 3D imaging, multiwavelength imaging, phase-division multiplexing of wavelengths, 2π-PDM",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/54085.pdf",chapterXML:"https://mts.intechopen.com/source/xml/54085.xml",downloadPdfUrl:"/chapter/pdf-download/54085",previewPdfUrl:"/chapter/pdf-preview/54085",totalDownloads:2036,totalViews:212,totalCrossrefCites:3,totalDimensionsCites:6,totalAltmetricsMentions:0,impactScore:2,impactScorePercentile:76,impactScoreQuartile:4,hasAltmetrics:0,dateSubmitted:"May 11th 2016",dateReviewed:"December 19th 2016",datePrePublished:null,datePublished:"March 22nd 2017",dateFinished:"February 11th 2017",readingETA:"0",abstract:"In this chapter, we introduce multiwavelength digital holographic techniques and a novel multiwavelength imaging technique. General multiwavelength imaging systems adopt temporal division, spatial division, or space-division multiplexing to obtain wavelength information. Holographic techniques give us unique multiwavelength imaging systems, which utilize temporal or spatial frequency-division multiplexing. Conventional multiwavelength digital holography systems have been combined with one of the methods listed above. We have proposed phase-shifting interferometry selectively extracting wavelength information, characterized as a multiwavelength three-dimensional (3D) imaging technique based on holography and called phase-division multiplexing (PDM) of multiple wavelengths. In PDM, wavelength-multiplexed phase-shifted holograms are recorded, and multiwavelength information is separately extracted from the holograms in the space domain. Phase shifts are introduced for respective wavelengths to separate object waves with multiple wavelengths in the polar coordinate plane, and multiple object waves are selectively extracted by the signal processing based on phase-shifting interferometry. Additionally, the system of equations needed to obtain a multiwavelength 3D image is solved with less wavelength-multiplexed images using two-step phase-shifting interferometry-merged phase-division multiplexing (2π-PDM), which makes the best use of 2π ambiguity of the phase and two-step phase-shifting method. The PDM techniques are reviewed and color 3D imaging ability is described with numerical and experimental results.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/54085",risUrl:"/chapter/ris/54085",book:{id:"5518",slug:"holographic-materials-and-optical-systems"},signatures:"Tatsuki Tahara, Reo Otani, Yasuhiko Arai and Yasuhiro Takaki",authors:[{id:"191368",title:"Ph.D.",name:"Tatsuki",middleName:null,surname:"Tahara",fullName:"Tatsuki Tahara",slug:"tatsuki-tahara",email:"tahara@kansai-u.ac.jp",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/191368/images/4627_n.jpg",institution:{name:"Kansai University",institutionURL:null,country:{name:"Japan"}}}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Phase-shifting interferometry selectively extracting wavelength information: phase-division multiplexing (PDM) of wavelengths",level:"1"},{id:"sec_3",title:"3. Numerical simulation",level:"1"},{id:"sec_4",title:"4. Two-step phase-shifting interferometry-merged phase-division multiplexing (2π-PDM)",level:"1"},{id:"sec_5",title:"5. Experimental demonstration of 2π-PDM",level:"1"},{id:"sec_6",title:"6. Discussions and summary",level:"1"},{id:"sec_7",title:"Acknowledgments",level:"1"}],chapterReferences:[{id:"B1",body:'\nD. Gabor. A new microscopic principle. Nature. 1948;161:777–778.\n'},{id:"B2",body:'\nE. N. Leith and J. Upatnieks. Reconstructed wavefronts and communication. J. Opt. Soc. Am. 1962;52:1123–1128.\n'},{id:"B3",body:'\nT. Kubota, K. Komai, M. Yamagiwa, and Y. Awatsuji. Moving picture recording and observation of three-dimensional image of femtosecond light pulse propagation. Opt. Express. 2007;15:14348–14354.\n'},{id:"B4",body:'\nT. Kubota. 48 years with holography. Opt. Rev. 2014;21:883–892.\n'},{id:"B5",body:'\nJ. W. Goodman and R. W. Lawrence. Digital image formation from electronically detected holograms. Appl. Phys. Lett. 1967;11:77–79.'},{id:"B6",body:'\nM. Takeda, H. 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Nakadate, and M. Shibuya. Digital holography with a quadrature phase-shifting interferometer. Appl. Opt. 2009;48:1308–1315.\n'},{id:"B55",body:'\nJ. -P. Liu and T.-C. Poon. Two-step-only quadrature phase-shifting digital holography. Opt. Lett. 2009;34:250–252.\n'},{id:"B56",body:'\nJ. Vargas, J. Antonio Quiroga, T. Belenguer, M. Servín, and J. C. Estrada. Two-step self-tuning phase-shifting interferometry. Opt. Express. 2011;19:638–648.\n'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Tatsuki Tahara",address:"tahara@kansai-u.ac.jp",affiliation:'
Faculty of Engineering Science, Kansai University, Suita, Osaka, Japan
PRESTO, Japan Science and Technology Agency, Kawaguchi, Saitama, Japan
Institute of Engineering, Tokyo University of Agriculture and Technology, Tokyo, Japan
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Horche",authors:[{id:"32748",title:"Prof.",name:"Alfredo",middleName:null,surname:"Martin-Minguez",fullName:"Alfredo Martin-Minguez",slug:"alfredo-martin-minguez"},{id:"44022",title:"Dr.",name:"Paloma",middleName:null,surname:"Rodríguez Horche",fullName:"Paloma Rodríguez Horche",slug:"paloma-rodriguez-horche"}]},{id:"23023",title:"Polarization-Selective Substrate-Mode Volume Holograms and Its Application to Optical Circulators",slug:"polarization-selective-substrate-mode-volume-holograms-and-its-application-to-optical-circulators",signatures:"Jing-Heng Chen, Kun-Huang Chen and Der-Chin Su",authors:[{id:"30776",title:"Prof.",name:"Jing-Heng",middleName:null,surname:"Chen",fullName:"Jing-Heng Chen",slug:"jing-heng-chen"},{id:"30788",title:"Prof.",name:"Kun-Huang",middleName:null,surname:"Chen",fullName:"Kun-Huang Chen",slug:"kun-huang-chen"},{id:"43662",title:"Prof.",name:"Der-Chin",middleName:null,surname:"Su",fullName:"Der-Chin Su",slug:"der-chin-su"}]},{id:"23024",title:"Holographic Synthesis of Diffraction Free Beams and Dark Hollow Beams",slug:"holographic-synthesis-of-diffraction-free-beams-and-dark-hollow-beams",signatures:"G. Martínez Niconoff, P. Martínez Vara, J. Muñoz Lopez and A. Carbajal Dominguez",authors:[{id:"29025",title:"Dr.",name:"Gabriel",middleName:null,surname:"Martinez-Niconoff",fullName:"Gabriel Martinez-Niconoff",slug:"gabriel-martinez-niconoff"},{id:"140189",title:"Prof.",name:"Martínez",middleName:null,surname:"Vara",fullName:"Martínez Vara",slug:"martinez-vara"},{id:"140192",title:"Prof.",name:"J",middleName:null,surname:"Muñoz Lopez",fullName:"J Muñoz Lopez",slug:"j-munoz-lopez"},{id:"140193",title:"Prof.",name:"Adrián",middleName:null,surname:"Carbajal Dominguez",fullName:"Adrián Carbajal Dominguez",slug:"adrian-carbajal-dominguez"}]},{id:"23025",title:"Optimization of Hologram for Security Applications",slug:"optimization-of-hologram-for-security-applications",signatures:"Junji Ohtsubo",authors:[{id:"32623",title:"Prof.",name:"Junji",middleName:null,surname:"Ohtsubo",fullName:"Junji Ohtsubo",slug:"junji-ohtsubo"}]},{id:"23026",title:"Nanophotonic Hierarchical Holograms: Demonstration of Hierarchical Applications Based on Nanophotonics",slug:"nanophotonic-hierarchical-holograms-demonstration-of-hierarchical-applications-based-on-nanophotonic",signatures:"Naoya Tate, Makoto Naruse, Takashi Yatsui, Tadashi Kawazoe, Morihisa Hoga, Yasuyuki Ohyagi, Yoko Sekine, Tokuhiro Fukuyama, Mitsuru Kitamura and Motoichi Ohtsu",authors:[{id:"32567",title:"Dr.",name:"Naoya",middleName:null,surname:"Tate",fullName:"Naoya Tate",slug:"naoya-tate"},{id:"43823",title:"Dr.",name:"Makoto",middleName:null,surname:"Naruse",fullName:"Makoto Naruse",slug:"makoto-naruse"},{id:"43824",title:"Dr.",name:"takashi",middleName:null,surname:"Yatsui",fullName:"takashi Yatsui",slug:"takashi-yatsui"},{id:"43825",title:"Dr.",name:"Tadashi",middleName:null,surname:"Kawazoe",fullName:"Tadashi Kawazoe",slug:"tadashi-kawazoe"},{id:"43826",title:"Dr.",name:"Morihisa",middleName:null,surname:"Hoga",fullName:"Morihisa Hoga",slug:"morihisa-hoga"},{id:"43827",title:"MSc",name:"Yasuyuki",middleName:null,surname:"Ohyagi",fullName:"Yasuyuki 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1. Cultural heritage
The concept of cultural heritage refers to the cultural inheritance that corresponds to a given community and as such is protected and communicated to both the present and the future generations. This concept is subjective and dynamic, and it does not depend on the objects or goods, but on the values that society in general attributes to them at each moment of history and that determine which goods are those that must be protected and preserved for posterity. Therefore, the identification, protection, conservation, and dissemination of the world’s cultural heritage are one of the most recognized tasks of the United Nations Organization for Education, Science and Culture [1, 2, 3].
Cultural heritage is made up of tangible or intangible assets that history has left to a country and those citizens in the present grant it a special and relevant historical, scientific, symbolic or esthetic importance. This inheritance left by our ancestors and received today is the clear testimony of their existence and vision of the world [4].
The tangible heritage is also called material heritage, and there are movable and immovable property such as the objects of the artistic collections such as the collection of religious, ethnographic, technological, historical, artistic, and archeological and artisan objects. The real tangible heritage is made up of archeological sites, engineering works, places, buildings, and architectural ensembles.
The intangible cultural heritage includes the wealth of knowledge, also living expressions inherited from our ancestors and transmitted to our descendants, such as language, oral traditions, customs, performing arts, ways of life, rituals, festive events, knowledge, and practices related to nature and the universe, as well as knowledge and techniques linked to traditional crafts [5].
Cultural heritage is a nonrenewable resource with regard to its past, and that is why it manifests itself tangibly as an untouchable and irreplaceable resource of a people. This heritage is always linked to the human collective, since it is men and women who produce it, and therefore it is what gives identity, origin, and continuity to our people. Hence, it is the responsibility of all its conservation and restoration for which it is essential to know what are its main threats in order to prevent, delay its deterioration and, if necessary, restore this heritage.
The alteration of cultural assets is the characteristic of the continuous cycle of disintegration and reconstruction, and it is a natural condition since all matter follows a process of alteration, degradation, or decomposition which means that original physical, chemical, and optical qualities are lost and enter a process of instability promoted by factors or agents of deterioration that are of two types:
Intrinsic: it depends on the nature of the material, manufacturing technique, and procedures that were used to perform the work.
Extrinsic: It depends on the sources external to the object such as environmental factors (light, relative humidity, temperature, and air pollutants), anthropogenic factors (handling, use, consultation, vandalism, tourism, etc.), biological factors (microorganisms, plants, rodents, and insects), and catastrophic factors (floods, fires, etc.) [6, 7, 8].
Among the main mechanisms of deterioration, three processes are known:
Physical or mechanical processes where the behavior of the material is modified, where several mechanical forces participate (compression, traction, etc.). These change the behavior of a material without modifying its chemical composition.
Chemical processes: are those that compromise a chemical reaction that transforms the matter.
Biological processes: where living organisms, such as microorganisms, insects, rodents, plants, etc., can chemically attack the material or its mechanical resistance. This process is also known as biodeterioration, which has been defined as “undesirable changes in the properties of materials caused by the vital activity of organisms” [9].
2. Biofilms as biodeteriogens
It is expected that works of art last for a long period of time; however, these suffer deterioration, and previously it was believed that chemical and physical processes were the dominant factors in the degradation of materials. Since 1967 and in latter decades, dogma has changed, and today it is assumed that microorganisms only by their very presence can cause damage by esthetic destruction of the materials since they inhabit them and penetrate causing their loss due to their acid corrosion, enzymatic degradation, and mechanical attack [10]. These microorganisms can grow in nature in large, silty colonies known as biofilms where relationships and dependencies are established [11, 12, 13].
Biofilms are microbial monospecies or multispecies (consortium) communities that have demonstrated the most successful colonization among microorganisms are ubiquitous in nature and responsible for many diseases. They are considered growing communities of microorganisms embedded in a self-produced exopolysaccharides matrix and are attached to an inert surface or living tissue [14, 15, 16]. The microorganisms in biofilms have properties that are not shared by free organisms, and the requirements for the formation of biofilms are simple: surface, moisture, nutrients, and microorganisms. This complex microbial organization that can consist mainly of bacteria and fungi, offers several advantages for its survival, such as resistance to environmental stress through the formation of stable microcolonies, facilitates the exchange of genetic material, and there is accumulation of nutrients and water in its matrix that offers protection against toxic substances (biocides and antibiotics) and against desiccation as well as immune defenses in the case of the formation of biofilms in higher organisms [17].
The importance of biofilms in the biodeterioration of cultural heritage has been reported for several decades and is related to: (a) modifications in pH values and ionic concentrations, (b) reduction oxide conditions in the interface of biofilms and substrate, (c) covering the surface and masking its properties, (d) increasing the leaching of additives and monomers outside the polymer matrix by microbial degradation, (e) releasing enzymes that lead to embrittlement and loss of mechanical stability, (f) accumulating water that penetrates the matrix causing swelling and increased conductivity, and (g) excretion of lipophilic pigments among others [18, 19].
3. Biodeterioration of stone
The mineralogical nature of the stone, its surface properties, and environmental conditions act synergistically for its bioreceptivity (ability to be colonized by microorganisms), and its intensity will depend on the concentration of pollutants, microclimatic conditions, and anthropogenic eutrophication of the atmosphere [20].
The climatic conditions in which the monuments or architectural structures are exposed can be the wind that wears the rock eroding it, the solar radiation causing discoloration, the temperature, as well as the rain, snow and humidity that induce the process of physical and chemical wear. These factors affect the stability of the matrix of the stone or act through chemical corrosion forming minerals by oxidation and hydration reactions as well as by the dissolution of carbonates and solubilization of some elements of minerals with silicates [21, 22].
The microbial communities after the interaction with biotic and abiotic factors are developed using the stone as a substrate and are partially responsible for the chemical and physical deterioration of the same and alter the esthetic appearance and physical integrity of the material through different mechanisms (Figure 1). The effects of microbial activities on historic buildings may be: discoloration, water retention, growth stimulation of heterotrophic organisms and higher organisms, material breakage, disintegration of the material, formation of patinas, degradation (corrosion), wear and dissolution of the structure, alkaline dissolution, and alteration of stratified silicates [23].
Figure 1.
Biodeterioration on stone (photo: Laura Castillón).
The microorganisms that colonize the stone monuments can be distinguished according to their location in the stone. The so-called epilithic that are located on the surface of the rock and those that live inside the rock within fractures and cracks and pores in granites are known as endolithic [12]. The main microorganisms that play a potential role in biodeterioration are autotrophic and heterotrophic bacteria, fungi, algae, and lichens. Phototrophic microorganisms such as microalgae, cyanobacteria, and lichens are considered the pioneer colonizers of the surface of stone monuments.
Cyanobacteria and algae such as chlorophytes, chrysophytes, and diatoms are a morphologically diverse and widely distributed group endowed with remarkable adaptability to variable environmental conditions and effective protection mechanisms against various abiotic stresses that enable them to colonize almost all classes of extreme lithic habitats [24]. These microorganisms form pigmented scabs (patinas) and incrustations that affect the substrate esthetically and cause physical and chemical deterioration of the rock. The epilithic cyanobacteria play an important role in the dissolution of the limestone carbonate, being able to cause the detachment of parts of it, due to a decrease in the coherence of the crystals around the colonies [25, 26].
The external stones are an appropriate niche for the growth and development of pioneering microorganisms that include photoautotrophs, lithophiles, and chemolithotrophs. The colonization begins with cyanobacteria and algae, probably followed by lichens that synthesize extracellular organic matter, in addition, dead cells release their constituents that form sources of nutrients for the growth of heterotrophic microorganisms which are considered secondary colonizers [27]. The phototrophic metabolism of cyanobacteria and algae facilitates their growth in oligotrophic environments such as stone forming biofilms on rocky surfaces, and it is the characteristics of the substrate that determine the speed of their growth and therefore the intensity of biodeterioration [28]. Lichens are highly resistant to extreme temperatures and desiccation that allow their easy growth on the surface of the stone. The microbial populations present in the rocky substrate are the result of successive colonization by different heterotrophic microorganisms.
It is well known that stone surfaces are exposed to high levels of solar radiation, high temperature, and to prolonged periods of desiccation alternating with rainy and damp periods. Many cyanobacteria are known to tolerate environmental extremes like UV light and their resistance to desiccation and tolerance for high level of light intensities and UV radiation provide them a distinct advantage for their survival on exposed surfaces, and they synthesize UV sunscreen pigments including scytonemin, mycosporine like aminoacids and biopterin glucosides. There are several reports on the effect of UV radiation on nitrogenase activity as it relates to the role of cyanobacteria in the nitrogen economy of ecosystem [29].
Pigmentation as a mechanism of deterioration depends on the nature of the substrate, the presence of trace elements such as iron, zinc, etc., the acidity or basicity of the medium, and even environmental conditions. The microorganisms produce two types of pigments (a) endopigments: they are located inside the cell and only leave after the lysis of the same as photosynthetic pigments, such as chlorophyll and phycobilins and (b) exopigments emitted outside the cell as fungal pigments (black, violet, blue, green, and purple). The black pigment known as melanin protects fungi against environmental threats and cellular lysis. Moreover, mycosporines and carotenoids (ß-carotene, s-carotene, phytoene, torulene, and torularhodin) may protect fungi against excessive UV radiation, act as antioxidants, osmoprotectants, and provide desiccation tolerance [30, 31].
The wear of materials is accelerated by the presence of biofilms containing active and latent microorganisms and their metabolic products, such as corrosive organic and inorganic acids as well as polymeric materials. Polymers, usually polysaccharides, act as gums that trap dust and other particulate materials increasing the disfiguring effects of the biofilm [32].
Beyond the type of microorganisms, the formation of the biofilm is a biodeterioration factor. The exopolysaccharide matrix plays a crucial role in this phenomenon since it produces mechanical stress on the stone through the pores of the mineral structure because it modifies the circulation of water within the material, its sensitivity to temperature variations, and the cycles of swelling and contraction dependent on the concentration of water within the matrix [27, 33].
Biofilms are also associated with the degradation of buildings and mural paintings by a phenomenon known as salt efflorescence, involves secondary minerals produced through the reaction of anions from excreted acids with cations from the stone which is available in the wall by the biological process or simply due to comigration with the infiltrated water. The solubilization of the calcareous material is detected by the presence of hygroscopic salts including carbonates, chlorides, nitrates, sulfates, etc., can be found on the surfaces of decayed monuments caused by chemical reactions (chemical agents in the air) or by enzymatic reactions of certain microorganisms. The most frequently isolated genus was Bacillus, followed Staphylococcus, Kocuria, Micrococcus, Paenibacillus, and Arthrobacter (bacteria of the sulfur and nitrogen cycle) [34].
The precipitation of salts is due to changes in temperature or humidity, and the salts can precipitate on the exposed surfaces and cause a destructive effect. Some salts when hydrated occupy a large space causing additional pressure that eventually leads to the loss of material and destruction due to cracking and detachment of walls or calcareous structures. In studies conducted by electron microscopy of salt efflorescence zones on walls, biofilms have been reported by members of Firmicutes, Actinobacteria, and Ascomycota [13, 35, 36].
From the nutritional point of view, organisms show a wide range of metabolic modalities where they use different sources of carbon (organic or inorganic compounds) as well as light as an energy source, and they are classified as photoautotrophic, chemoautotrophs, chemoheterotrophs, chemoorganotrophs, and photosynthetic.
The main mechanisms of biodeterioration associated with the different types of stone-colonizing organisms according to their nutrition are presented in Table 1 [20].
Table 1.
Mechanisms of biodeterioration.
Microbial colonization on bare stone surface is thought to be initiated by pioneering microorganisms which includes photoautotrophs, lithophiles, and chemolithotrophs. These organisms may secrete carbohydrates and growth factors which help in the formation of biofilm (a three-dimensional structure regulating temperature and humidity) and support the growth of successive microbial communities that is predominated by heterotrophic bacteria and fungi [20].
Limestones are carbonate rocks composed of calcite, and their main uses are in construction, chemical products, smelting, agrochemicals, and glass. This material is highly porous and hydrophilic in nature, and it is highly susceptible to water (such as acid rain) and environmental contaminants. Water often penetrates the pores of the stones causing damage by corrosive ions such as chlorine and acids. Biofilms, industrial and persistent pollutants, particulate matter, ash and often smog are deposited on the stone, and as a result, its deterioration is accelerated [23, 37].
The wear of the rocks and monuments can also be a consequence of the removal and solubilization of cations present in the minerals of the stone in particular iron and manganese of the mineral network by the negatively charged exopolysaccharide (EPS) of the biofilms or by some microbial proteins called siderophores by organic transport complexes and metallic organic chelates. Under low iron stress, siderophores chelate iron and supply to bacterial and fungi cells by outer membrane receptors, and the role of these compounds is to scavenge iron from the environment and to make the mineral, which is almost always essential, available to the microbial cells [38, 39].
The ability to grow by the dissimilatory oxidation of inorganic electron donors (ferrous iron, hydrogen, sulfur, and reduced inorganic sulfur anions) is widespread among acidophilic prokaryotes. Both oxygen and ferric iron can act as electron acceptors from many species of chemolithotrophic acidophiles, enabling them to exploit anoxic as well as aerobic environments [40].
In aerobic conditions, electron donors may include ferrous ions or sulfur compounds which are oxidized into ferric iron and sulfuric acid, respectively, yielding high energy. However, during anaerobic conditions, ferric ions can replace oxygen as the electron acceptor with multiple substrates donating an electron. This pathway yields less energy than aerobic conditions, but energy can still be produced for growth. A. ferrooxidans is a chemolithoautotrophic bacterium which can use many different electron donors to support growth Leptospirillum spp. have been shown to use only ferrous iron as electron donor and are therefore (as a result of thermo-dynamic constraints) obligate aerobes.
The subsequent redox process is favored by the release of oxygen by photosynthetic bacteria, cyanobacteria as Acidithiobacillus ferrooxidans, Bacillus spp., Leptospirillum ssp., and chemoorganotrophic fungi such Aureobasidium spp. [24, 41, 42].
Mechanical damage to stone structures, monuments, and architecture is another type of biodeterioration mechanism which is due to the physical intrusion and penetration of bacteria, fungal hyphae in the gaps, pores, and fractures that destabilize the texture of the stone, causing mechanical deterioration or by the contraction, and expansion of the stem under fluctuations in humidity conditions. Also the mosses through the rhizoids can penetrate the rock causing holes (pitting) and the vascular plants through their mechanical deterioration through the growth of roots or chemically by the acidity and diverse exudates, alteration of the microclimatic parameters, increase of the risk of fires, and physical and visual obstruction [26, 43].
4. Biodeterioration of paintings
The chemistry of the manufacture of paintings and their function has now been transformed from art to science. The knowledge of the pictorial components allows to associate the type of microorganisms that can potentially colonize the paintings, and the different techniques used determines the final composition of the work.
The pictorial technique has multiple modalities: tempera, encaustic, fresco, mural, and oil among others. The first three techniques were used in the ancient Greco-Roman and Egyptian world. (a) Tempering consists basically of the mixture of earths or pigments with binder constituted by glue and water or by egg yolk and oils in any type of support, (b) encaustic or wax painting requires a previous preparation of the wall by means of wax, on which colors are applied to the tempera cast in wax using a hot palette, and (c) the fresco that consists essentially of painting on a surface of wet plaster, on the same wall, prepared by the artist himself [44]. This latter is the modality of frequent use and is performed on wet lime plaster that serves as a support for the various pigments dissolved in water which are chemically integrated into the wall, and so its durability is very high, and (d) oil is the best known pictorial technique and used on cloth or board. It consists of a mixture of colored pigments with oil, usually flax or walnut. Another technique related to painting on canvas is acrylic, which consists of a combination of acrylate molecules in emulsion with water [45].
The deterioration of a painting can have different origins such as: (a) alterations due to natural aging of the work that makes it more fragile, (b) defects inherent to the work such as low quality materials or bad techniques at the moment of being painted, and (c) influence of external conditions such as thermo-hygrometric conditions or other factors. The manifestations of the damage can be physical as lack of adhesion of the binder, or damage caused by the movements of the other, mechanical damage, etc. Chemical damage is manifested as a processes of gradual degradation and depolymerization or crosslinking of the materials of the work, damage caused by light, oxidation or biological attack [46, 47, 48, 49].
The biodeteriorable character of the canvas is conditioned by the characteristics of the fabrics that are its support formed by cellulose fibers which is a polysaccharide whose constituent unit is D-glucose linked by glycosidic bonds β (1–4) forming linear chains, which in turn are links in parallel fibers called microfibrils. For cellulose, degradation involved different enzymes whose combined action allows obtaining glucose molecules that can be assimilated by microorganisms as a carbon source. The degree of polymerization and its orientation, the length of these chains, their crystallinity, and their orientation are detected by microorganisms and could be susceptible to biodeterioration. The susceptibility to biological attack depends on the percentage content of cellulose, lignin, and other organic components. The purest cellulose can hardly be attacked. Alternaria, Aspergillus, Fusarium, Memnoniella, Myrothecium, Neurospora, Penicillium, Scopulariopsis, Stachybotrys, Stemphylium, and Chaetomium are the main fungi associated to this process and as cellulolytic bacteria: Cellvibrio, Sporocytophaga, Myxococcoides, Cellufalcicula, and also Clostridium sp. as anaerobic bacteria has been reported [50]. This cellulolytic process is favored in conditions of relative humidity of high air or condensation water where the fiber of the fabric loses consistency and elasticity becoming brittle and falls apart.
The filmogenic substances act as a binder and as a vehicle for the pigments; they are mainly of organic origin; they are applied in liquid form, and with drying, they solidify forming a hard and flexible layer, with the passage of time and under certain adverse conditions, this layer loses its property of cohesion of pigments and causes dusty surfaces or the separation of the layers.
The most important component of the paintings on canvas is the pigments; they are either natural or synthetic origin, and have three main functions: they provide color, opacity, and brilliance, and protect the surface in which they are applied and protect the binder from its destruction by UV radiation.
The adhesives are a fundamental element for the final result of the work whose function is to facilitate a uniform distribution of color and prevent the paint layer from being absorbed by the fabric, and these adhesives have been changing in the course of history and have been classified depending on their origin in animal (gelatin, albumin, casein, and wax) and vegetal (starch, resins, gums, and gluten).
Gelatin is obtained from collagen which is an existing protein in the skin and cartilage, albumin (protein of egg or blood plasma), casein (protein of milk), and wax (secreted by bees composed of a mixtures of esters, hydrocarbons, and fatty acids). The starch is a polysaccharide of vegetable origin, which is formed predominantly of amylose and amylopectin. Vegetal resins are a mixture of organic compounds principally terpenes and derivatives. Gums consisting of mixtures of water soluble polysaccharides produced by exudation, usually from the stem of tree and gluten, refer to the proteins in cereal grains found in the endosperm plant embryos during germination (Coppen, 1995).
The organic composition of all these adhesives favors the growth of microorganisms due to their high nutritional content, and therefore they are easily attacked by them [30].
The use of varnishes is required to provide protection against environmental attacks. For them, natural or synthetic varnishes (resins) are used, which must be applied in such a way that they form a resistant, colorless, and transparent film. According to its chemical composition, the name of the natural resins (soft) depends on the number of isoprene units that contain such terpene molecules as monoterpenes, sesquiterpenes, diterpenes, and triterpenes. The deterioration of natural resins causes chemical changes such as polymerizations (crosslinking of polymer chains, hydrolysis of polymer chains, and oxidation of the main chain or side groups which causes the resin to become more insoluble, losing its resistance and changes in its coloring [51]. Synthetic (acrylic) resins have good adhesive properties and are currently widely used in preservation treatments, and the monomers of these resins are generated by the esterification of an acrylic acid with several alcohols. Its general formula is: CH2CR1COOR2 and due to its hydrophobic nature are more resistant to microbial attack because they are not used as a source of nutrients [52, 53].
Among the forms of deterioration of pictorial heritage on canvas related to biodeterioration agents are [54]:
Alterations of the canvas: hydrolysis, colorations, loss of strength, loss of support, cracks, scales, and deformations.
Alterations of the binder/adhesive: enzymatic degradation, colorations, disintegration, and pulverulence.
Alterations of the varnish: yellowing, tiling, whitening, and peeling.
The biological origin of deterioration in paintings has been widely reported in wall and easel paintings since the 1980s in different parts of the world [49, 54], and in general, the main fungal species associated with the biodeterioration of painted walls are Penicillium sps., A. niger, Rhizopus oryzae, Mucor, Trichophyton, Alternaria alternate, and Epidermophyton floccosum [55, 56] and as biofilms Acremonium, Cladosporium, Aspergillus, and Fusarium [57]. In the case of canvases of oil paints, the bacterial strains of the phylum firmicutes such as Bacillus sp., Micrococcus luteus, and Paenisporosarcina sp. and nonculturable bacteria of the phylum Proteobacteria such as Stenotrophomonas sp. [58] as well as Halobacillus sp., Halobacillus naozhouensis, and Nesterenkonia sp. in wall paintings responsible for pigmentation by pink biofilms in Romanian monasteries [59].
The mere presence of microorganisms (colonization) in any type of surface does not determine their participation in the biodeterioration process, to be able to specify it, experimental strategies have been developed in the laboratory where traditional supports such as linen cloth prepared with layers enriched in gums of animal origin and linseed oil that are inoculated with suspensions of fungi and bacteria, later identifying the species that grow and deteriorate these materials, thus checking the postulates of Koch [60]. Another report associated with this proposal was made in the murals of the medieval church with the bacterium Arthrobacter responsible for the black spots as a result of the reaction of lead oxide of pigments and hydrogen sulfide produced by other bacteria responsible for spotting [61]. These models will allow to establish, under controlled conditions, which species colonize a given substrate and how the flora will change the substrate and how the substrate is modified by microbial colonization and how these modifications lead to the establishment of different microbial communities (microbial succession) [62].
There are several reports of the participation of biofilms as responsible for biodeterioration in the pictorial cultural heritage as in the case of the works of the Nerja and Treasure in Málaga [63], the church of St. Martins in Greene-Kreiensen, Germany [64], and the Mogao caves in Dunhuang, in Gansu Province of the People’s Republic of China [65] among others. As an example of these works, mucilages have been analyzed in fragments detached from frescoes of the Santissima Annunziata Church in Siena Italy in damaged areas, and the presence of biofilms has been demonstrated where their growth is favored by external factors such as humidity, poor ventilation, and light which may be associated with biodeterioration, because their hydration retains particles and atmospheric pollutants that accelerate chemical corrosion by oxidation, reduction, and transformation of metal ions with the changes in the pigments in addition to the coexistence of saline efflorescence making the bioreceptives fresh and causing detachment of the paint layers [66].
Another threat has been reported to the cultural heritage of biodeterioration in frescoes caused by the presence of tourism such as the case of The Lascaux Cave, which is the most emblematic example of the damage that micro-organisms cause to mural paintings due to the amount of organic matter, respiration, and the sweat of visitors and workers that increased the concentration of CO2 favoring the growth of the fungus Fusarium solani and Ochroconis lascauxensis (black spots) and the alga Bracteacoccus minor forming a green patina (green disease) causing irreversible damage so it closed its access permanent visitors [62, 67].
At present, we must consider the use of commercial paints (canned) which, due to their composition, represent a carbon source for a large number of microorganisms and which can be a source of contamination and colonization for the surfaces in which they are applied. Pseudomons, Flavobacterium, Escherichia, Bacillus, Enterobacter, Proteus, Micrococcus, Serratia, Aeromonas, or Stenotrophomonas maltophilia, among others, have been reported in water-based paints, this contamination can occur during their production with the use of contaminated water or in the team [68, 69, 70].
5. Biodeterioration of textiles
Textiles are considered representative of cultural identity because they carry a significant value that transcends that of their materials and the work required for their manufacture. The desire of all cultures to express and communicate their social, esthetic and cultural values in their textile manifestations, and materials such as clothing or basketry (with ceremonial or ritual destination), are a unique cultural heritage, and the assignment of cultural value to a material object is the basis of conservation [71].
Textiles, such as clothing, fashion accessories, archeological objects, baskets, quilts, tapestries, embroideries, flags, funerary, and religious garb are often treasured for their artistic, technical, cultural and sentimental value, and for this reason, they are currently stored in collections in museums [72].
The textile heritage is very extensive, despite the loss to which it has been subjected throughout history, mainly due to the characteristics of its delicate materials and the interventions that have suffered and suffer from this type of pieces. The gradual deterioration of this material is very sensitive and can only be slowed down, the daily use of these fabrics, inadequate handling and bad storage conditions have caused the loss of unrepeatable textiles because the same materials and techniques are not available as well as the techniques that were used in their preparation that are already part of our past [73]. The state of preservation of textiles depends on the type of textile fiber, composition of the dye, age of the textile as well as its history of use and storage conditions.
It is called textile fiber to the set of filaments or strands susceptible to be used to form yarns (and of these fabrics). In the manufacture of the yarn for textiles, two types of fiber can be used: natural or synthetic. The natural fibers can be of animal or vegetable origin. In the first, they are generally of the protein type, such as wool from sheep’s hair, goat, camelid, rabbit or another type of natural fiber such as silk from the silkworm. Among the natural fibers of plants include cotton, linen hemp, and jute among others. Synthetic fibers include polyester, polyamide polyurethane, polypropylene, polyacrylonitrile, and polyvinyl [74, 75].
In addition to the passage of time and the environmental characteristics of conservation as a possible source of deterioration, the development and presence of various types of organisms (microorganisms, rodents or insects) which are a threat to textiles and damage will depend on the type of fabric, its origin as well as storage conditions. The presence and permanence will depend on the availability of nutrients as well as light, humidity, and temperature conditions. The degradation of the materials that cause the damage by microorganisms is due to the processes of assimilation by fungi and bacteria that use these materials as a source of nutrients or to the degradation processes due to the effect of microbial metabolism.
The main manifestations of this process are the evident changes of the surface of these materials, discoloration, decrease in their resistance, changes in pH, and unpleasant odor. These damages can cause the total destruction of the material by the reduction of the degree of polymerization, decrease in its tensile strength, and elasticity. In general, natural fibers are more susceptible to microbial attack than synthetic fibers.
The main molecules responsible for the attack on textile fibers are organic acids, extracellular enzymes released or by exopigments of bacteria such as Achromobacer sp., Bacillus sp., Brevibacterium sp., Corynebacterium sp., Pseudomonas sp., Rhodococcus sp. and Streptomyces sp. or exopigments of fungi of the group Aspergillus sp., Penicillium sp., Cryptococcus sp., Rhodotorula sp., and others [76].
The biodeterioration mechanisms in textile objects will depend mainly on the type of fiber:
Cellulose fibers: The degradation of (1-4)-β-D-glucan or cellulose results from the activity of cellulolytic enzymes produced by several bacteria and especially fungi that hydrolyze cellulose to glucose by the enzymes: 1,4-β-D-glucan, cellobiohydrolase, endo-(1-4)-β-D-glucan glucanohydrolase, and glucohydrolase of β-D-glucosidases. These enzymes decrease the degree of polymerization of the long-chain cellulose molecules, resulting in a decrease in the strength of the fiber.
The presence of other components in fibers such as hemicellulose, pectins, other carbohydrates or substances added to fabrics (plasticizers) and even contaminants provide additional nutrients to microorganisms.
Among the genera of fungi associated with biodeterioration of cellulose are Chaetomium, Myrothecium, Memnoniella, Stachybotrys, Verticillium, Alernaria, Trichoderma, Penicillium, Aspergillus, Aureobasidium, Cladosporium, Fusarium, Mucor, Paecilomyces, Rhizopus, and Trichothecium. In the case of bacterial damage and with less significance, agents of degradation of cellulose are: Arthrhobacter, Bacillus, Cellulomonas, Cellvibrio, Clostirdium, Cytophaga, Microbiospora, Nocardia, Pseudomonas, Sporocytophaga, and Streptomyces [77].
Wool fibers: Keratin is the constituent protein of these fibers that form a polymer when disulfide bridges cross over this polymer. The mechanism of biodeterioration is by keratinolysis, sulfitolysis, proteolysis by peptidases, and deamination (metabolic processes with release of ammonia). The rate of degradation depends on the chemical composition, molecular structure, and degree of polymerization of the substrate and to a lesser degree on the structure of keratin [78].
Among the main biodeterioration agents are bacteria: Arthrobacter, Bacillus (B. mesentericus, B. subtilis, B. cereus and B. mycoides), Cellulomonas, Cellvibrio, Clostridium, Cytophaga, Microbiospora, Nocardia, Pseudomonas, Sporocytophaga and Streptomyces [79]. Degradation by fungi has been reported by the genera Microsporum, Trichophyton, Fusarium, Rhizopus, Chaetomium, Aspergillus, Penicillium, Alternaria, Acremonium, Cephalothecium, Chrysosporium, Dematium, Oospora, Scopulariopsis, Stachybotrys, Trichoderma, and Ulocladium [77, 80].
Silk fibers: They are produced by silkworms and are fibers of the fibroin protein that are joined to one another by rubber-like proteins, known as sericin that serves as protection from damage by light. This natural fiber is the most resistant to biodeterioration, and its decomposition depends on the proteolytic action on sericin and fibroin that are used as a carbon source by bacteria Bacillus, Aeromonas, Arthobacter, Chyseomonas, Pseudomonas, Streptomyces, Serratia and Variovorax and how biodeteriogenic fungal genera are: Aspergillus, Chaetomium, Cladosporium, Penicillum and Rhizopus [80].
There are very few works to which biofilms are directly associated as being responsible for biodeterioration in textile materials, and it may be the result that experimental designs have not been developed with these types of materials.
6. Biodeterioration of paper and parchments
The documentary production goes back in antiquity in different cultures that left numerous examples in different supports like tablets of mud, rolls of papyrus, parchment, sheet of amate and in more recent times the books. The invention of paper gave man a faithful support where the written memory will inhabit his journey through history, and thanks to its consistency and durability, the texts of our ancestors are still today, a faithful witness of his time [81].
The main components of paper are fiber or fibrous material (hemp, cotton, linen, bagasse, rice straw a,nd wood) and functional additives (sizing, optical brighteners, and consolidating agents such as gelatin, cellulose acetate and carboxymethylcellulose). In this chapter, cellulose fiber is the major component with a lower proportion of lignin, hemicellulose, and other macromolecules, its quality depends on the source of the raw material used, and the procedure applied to obtain the fiber. Its mechanical resistance depends on its degree of polymerization and its interfiber links.
The inks are an important component of the documents and consist of a liquid that is fixed to the support endowed with an intense, durable, odorless and variable pH, is composed of a pigment, a diluent and a binder. Among the oldest ones are ferrous ink, whose components are iron sulfate, gallotanic acid and a binder, usually gum arabic. Over time the components of plant and animal origin have been replaced by synthetic compounds [82].
The books are composed of a support (parchment or paper), supported elements (inks), binding elements (seams and adhesives), protective structures (covers), and each of them with particular chemical characteristics that can be elements of degradation [83].
The microorganisms that commonly appear in the documentary supports are bacteria and fungi (yeasts and filamentous fungi), which transport moisture and attract pests by modifying the nutritive environment of the substrate. Both colonize a susceptible medium when in a poorly ventilated place, with adequate pH and low illumination, where temperature higher than 25°C and ambient humidity greater than 65% with accumulation of dust and/or soot in the different types of surfaces.
Filamentous fungi are the most biodeteriogenic microorganisms because they have structures called hyphae that are vegetative and reproductive [14, 84]. Vegetative hyphae are intertwined in paper fibers and through enzymatic processes that degrade cellulose, absorb nutrients, produce acids, and affect the coloration of the support resulting in fragility of the paper and often its complete destruction (Figure 2). On the other hand, the reproductive structures (spores) are a potential threat because they can remain in a latent state, they can be airborne, and they accumulate in layers of dust as long as the environmental conditions for their germination are reached, such as the formation of condensation points and local microclimates due to poor ventilation and heterogeneous temperature on the surface of the material.
Figure 2.
Paper biodeterioration. (Photo: Laura Castrillón).
Among the fungi identified are the Ascomycetes as well as mitosporic xerophilic fungi (which grow with a small amount of water) such as those of the genus Aspergillus, Paecilomyces, Chrysosporium, Penicillium and Cladosporium [85] and among the cellulolytic bacteria Cellvibrio and Cellfacicula as well as Cytophaga (myxobacteria).
In the case of the parchments that are composed of collagen (protein), its degradation depends on the oxidative chemical deterioration of amino acid chains and hydrolytic breakdown of the peptide structure and the production of pigments and organic acids that modify this material. The bacteria that have been described in this process are those of the genera Bacillus, Staphylococcus, Pseudomonas, Virgibacillus and Micromonospora as well as some alkalophilic bacteria such as Actinobacteria and among the proteolytic fungi reported are the Ascomycetes: Chaetomium and Gymnoascus and the genus Acremonium, Aspergillus, Aureobasidium, Epicoccum, Trichoderma and Verticillium [13, 78].
7. Prevention, conservation, restoration, and control
To preserve the tangible cultural heritage, there are two ways of action: the prevention of deterioration (conservation) and the repair of damage (restoration). With the preventive conservation anticipates the damage generated by extrinsic causes, alien to the nature of the pieces to conserve, but that in more or less long term could degrade their cultural value.
Therefore, prevention methods and strategies are usually not directly applicable to the object to be treated, but are directed to the environment to control microclimatic conditions in order to eradicate harmful agents or elements that can temporarily or permanently influence degradation [82].
The prevention methods inhibit or slow down the biological growth modifying the factors that can condition or inhibit their presence (humidity, temperature, light, and ventilation), if these factors cannot be controlled as in the case of monuments or archeological zones can be modified eliminating dust, dirt and deposits of residues of plant or animal nature.
In contrast and in general terms, conservation can be defined as the set of operations that aim to prolong the life of the material, thanks to the anticipation of damage or the correction of deterioration.
In the field of the conservation of cultural goods, the purpose is to maintain the physical and cultural properties of what has reached the category of cultural property, with the purpose that its value does not diminish and lasts beyond a limited time segment. Preventive conservation, as a methodology aims to control the deterioration of works of art before they occur to reduce the need to intervene. The deterioration must be minimized and the optimum conditions of exhibition, transportation, handling, cleaning, and storage must be maintained [86]. Among the main measures applied for preventive conservation that have been incorporated in the facilities are: air conditioning free of biodeteriogens agents, environmental fumigations, humidity, and temperature control.
The restoration aims to recover the physical and functional integrity of the work, thanks to the correction of the alterations that it has suffered. Consequently, the curative methods are of direct application because they try to amend all the damages they have experienced through their own history, whenever these suppose mutilation or reduction of their documentary values. The restoration is more than an art is technical, thanks to the set of interdisciplinary scientific methods that give the work the authentic guarantee of the rigor of applied sciences to the field of conservation [87].
Restorers use the intervention techniques of biodeteriorated materials to eliminate the degradation products induced by microorganisms and if it is possible to delay their recurrence. The intervention treatment must be evaluated taking into account the identity of the biodeteriogens, degree and type of damage, safety of the treatment towards the materials of the object, risk for the worker, and possible environmental impacts. However, the growth of unwanted organisms will inevitably occur if the environmental conditions that favor their development persist.
Between the main methods of control of biodeteriogenic agents that grow as biofilms are:
Mechanical methods: they consist in the physical removal of fungi, bacteria, algae or any organism by shaving, abrasion, brushing, etc. Immediate but not lasting results are obtained, complete elimination is not achieved, and the results improve with the use of chemical agents.
Physical methods: modifying the temperature or pressure changes that are not suitable for the growth of organisms. Its biocidal effect depends on the denaturation or breaking of molecules of the organisms treated by breaking chemical bonds. Among these methods are electromagnetic radiation (microwave, ultraviolet rays, and gamma rays), anoxic treatments, and extreme temperatures. Its mechanism of action depends on its direct action with the genetic material or alteration of its structure and metabolic function.
Its main disadvantages are its high cost and the possible damage to the materials treated by its chemical alteration such as the pigmentation and hydrolysis of proteins and cellulose.
Chemical methods: these are the most commonly used intervention techniques through the use of biocides (disinfectants, bactericides or fungicides). Generally they are used in liquid or gas form, their mechanism of action is variable and they attack by disintegrating the bacterial or fungal membrane or by inhibiting their cellular processes, causing their death when they are used in the appropriate doses. Many products have been evaluated, however, due to their high risk and limited knowledge of the compatibility with the materials to which they apply their use has been limited. The selection of the biocide depends on the type of material, type of microorganism, and availability of the biocide. An additional problem is its long-term ineffectiveness [88].
A biocide can be a synthetic chemical, natural, of biological origin that is intended to destroy, counteract, neutralize, impede action or exercise control over any organism considered harmful to man. According to their action, they are divided into microbicides (bactericidal and fungicidal), growth inhibitors, and for the case of other organisms such as insects, rodents or birds, and there are also very toxic and lethal products such as pesticides, insecticides and/or repellents, acaricides, nematicides, avicides, rodenticides, etc.
A good biocide must have a broad spectrum of activity, be effective at low concentrations, be active over a wide range of pH, soluble in water, possess high persistence (effective over time), have low human and environmental toxicity, and have a low cost [89].
Among the main biocides used for the chemical treatment of tangible cultural goods are:
Thymol, orthophenylphenol (OFF), formaldehyde, pentachlorophenol, ethylene oxide, ethanol, etc., antibiotics and enzymes have also been used. For the best selection of the biocide, preliminary tests must be done to guarantee the innocuousness of the operation for the safety of the operator and absence of risk for the object not only immediately but in the long term. For this reason, the use of very strong and long retention solvents (glycols, formamide, turpentine, and butylamine) in the porous bodies has been ruled out.
The forms of application of the biocides are: sublimation, pulverization or fumigation, according to their possible solid, liquid or gaseous state. The solids in solution or dispersion have a longer time of action although less exterminating capacity. The sublimable solids have little penetrability and, unless they are applied in high concentrations, they become repellent air fresheners with little lethal efficacy.
Solvents that are unstable to light and have a tendency to yellow or polymerize are also eliminated (ethylenic compounds such as dipentene, turpentine, acetylacetone, N-methylpyrrolidone). These rules are applicable to all porous objects, paintings, polychrome sculptures, mural paintings, etc. In the area of textiles, the most suitable solvent is water. But there are fibers very altered or with very bad coloration that are too sensitive. Then we must resort to organic solvents but avoiding chlorinated solvents, taking into account an eventual acidity and the release of hydrochloric acid. Water-based solvents must be used with extreme prudence, since many materials can suffer deterioration [90, 91].
Because the control of pests that use chemicals that are generally expensive and have side effects in people and can deteriorate the material, the choice of a biocide is increasingly difficult, therefore alternatives substances with biocidal properties have been sought for many years such as the use of natural plant products for which more and more reports justify their use. Currently, there is already a database of the accumulated experience of a Spanish group of the use of natural extracts for disinfection and disinfestation of cultural goods [92], as well as the use of essential oils from medicinal plants such as Mentha piperita, Thymus vulgaris, Origanum compactum, Salvia officinalis, Artemisa absinthium and Lanandula angustifolia, among others [93, 94, 95].
The development of nanotechnology is currently an emerging field in the conservation of cultural heritage, consequently the FP7 NANOFORART project has arisen (nano-materials for the conservation and preservation of movable and immovable artworks) and as an example of its applications, there are reports of the use of zinc oxide nanoparticles to control fungal biofilms or nanosilver coated cotton fabrics application for antimicrobial textile finishing [96, 97, 98, 99].
Biological methods: another option for the control and restoration of works of art has been the use of microorganisms in the processes of biocleaning and biomineralización that are presented below:
Biocleaning: The accumulation of organic material on surfaces either by deposition of atmospheric particles, traces of colonization of microorganisms and organic substances allow the growth of bacteria and fungi. This accumulation can cause damages to the art work in response to the growth of microbial and are therefore considered biodeteriorating agents, however, in recent years, bacteria have been used for the conservation and restoration processes for the elimination of these organic materials. This procedure is known as biocleaning.
One of the advantages of the use of microorganisms over physicochemical treatments (which are very drastic) is that they use substrate-specific enzymes that do not degrade complex substances and adapt easily to environmental conditions. The microorganisms selected should be nonpathogenic and nonsporulating so that it is not a risk for workers after application and not be able to produce forms of resistance (spores).
Examples of these treatments have been documented for the removal in stone of black scale (hydrated calcium sulfate and carbon residues) caused by sulfur dioxide, hydrocarbons, and particulate matter (soot) emitted by the exhaust pipes of vehicles, which were removed with the use of Desulfovibrio desulfuricans bacteria [100]. Good results have also been obtained for the elimination of nitrates in marble under anaerobic conditions with the use of Pseudomonas denitrificans, Pseudomonas stuzeri, Pseudomonas pseudoalcaligenes or Paracoccus denitrificans [101]. Biological cleaning of mural paints has also been explored to eliminate the remains of organic matter from old restorations or insoluble saline efflorescence with the use of Pseudomonas stutzeri [102].
Biomineralization: A modern and ecological alternative applicable to the restoration of historical monuments is the process known as biomineralization, specifically carbonatogenesis that can help in the restoration of cracks of statues or walls, since there are bacteria capable of mineralizing and filling these grooves when feeding them with means of culture that contain calcium salts in solution producing microcrystals of calcium carbonate that allow the restoration of damaged areas [103, 104, 105, 107, 108].
The carbonatogenesis or calcite production can occur either autotrophically or heterotrophically by the Bacillus, Pseudomonas, Proteus, Myxococcus and Pantoea agglomerans bacterial genera that allow obtaining a layer of a few millimeters thick by carbonatogenesis. Among the micro-environmental factors related to this process are: the concentration of dissolved inorganic carbon, the pH, the concentration of calcium ions and the presence of nucleation sites / or development of crystals for nucleation [23, 106].
8. Conclusion
In addition to the passage of time and environmental characteristics of the detriment of artistic and cultural heritage, this may also be the consequence of the microbial appearance favored by the enrichment of organic matter on the surfaces that colonize. The formation of biofilms is a strategy used by microorganisms to adapt to conditions that may be adverse for their growth. These biofilms are present in almost any type of surface, and the historical heritage is no exception. For the reason, it is important to know the characteristics that favor their formation, elimination and control to avoid being a threat to these objects.
As these biofilms represent a threat to this cultural heritage, the main challenges are to establish prevention measures for their appearance and to understand that if an intervention treatment is necessary, the resistance to treatment with biocides increases with this form of organization, which requires the use of high doses that compromise the physicochemical characteristics of the treated material.
The knowledge of the chemical composition of works of art made in different substrates such as stone, paintings, textile fibers, and paper composition allows us to understand what type of microbial colonization can be favored, and consequently be able to propose microbial growth as the responsible of biodeterioration. If these objects are valuable as a cultural heritage, it is the responsibility of all their conservation and restoration, for this reason the advanced techniques of identification and control of biofilms in cultural assets, currently, they are applied as strategies in the areas of preservation, restoration and control that will delay their natural deterioration and allow future generations to know this legacy.
\n',keywords:"biofilms, cultural heritage, biodeterioration, art biodeterioration",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/62795.pdf",chapterXML:"https://mts.intechopen.com/source/xml/62795.xml",downloadPdfUrl:"/chapter/pdf-download/62795",previewPdfUrl:"/chapter/pdf-preview/62795",totalDownloads:1521,totalViews:432,totalCrossrefCites:6,dateSubmitted:null,dateReviewed:"June 18th 2018",datePrePublished:"November 5th 2018",datePublished:"April 3rd 2019",dateFinished:"July 24th 2018",readingETA:"0",abstract:"Biodeterioration is defined as the undesirable change in the properties of materials caused by the activity of biological agents. This process is complex and involves alterations in the physicochemical and mechanical properties by the action of organisms and depends on the microorganisms involved, type of substrate, and environmental conditions. The biodeterioration of cultural heritage is the physical or chemical damage caused by microorganisms on objects, monuments, or buildings that belong to the cultural heritage. Among the main materials that can be affected are: stone, metal, ceramic, polymers, and other materials. Among the main undesirable effects to these materials are: discoloration, dissolution, rupture, and efflorescence among others. Biofilms represent the usual form of growth of bacteria and consist of communities of microorganisms that grow attached to an inert surface or a living tissue, surrounded by an extracellular matrix that they themselves synthesize. The importance of biodeterioration by biofilms is mainly related to changes in pH values, ionic concentrations, oxide-reduction reactions in the biofilm thickness, and in the interface with the substrate and enzymatic degradation. This chapter presents evidence of the participation of biofilms and associated mechanisms in biodeterioration as well as the main prevention and control strategies.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/62795",risUrl:"/chapter/ris/62795",signatures:"Laura E. Castrillón Rivera, Alejandro Palma Ramos,\nJorge I. Castañeda Sánchez and María Elisa Drago Serrano",book:{id:"8427",type:"book",title:"Antimicrobials, Antibiotic Resistance, Antibiofilm Strategies and Activity Methods",subtitle:null,fullTitle:"Antimicrobials, Antibiotic Resistance, Antibiofilm Strategies and Activity Methods",slug:"antimicrobials-antibiotic-resistance-antibiofilm-strategies-and-activity-methods",publishedDate:"April 3rd 2019",bookSignature:"Sahra Kırmusaoğlu",coverURL:"https://cdn.intechopen.com/books/images_new/8427.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:"978-1-78985-790-0",printIsbn:"978-1-78985-789-4",pdfIsbn:"978-1-83962-103-1",isAvailableForWebshopOrdering:!0,editors:[{id:"179460",title:"Associate Prof.",name:"Sahra",middleName:null,surname:"Kırmusaoğlu",slug:"sahra-kirmusaoglu",fullName:"Sahra Kırmusaoğlu"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"59716",title:"Dr.",name:"Maria Elisa",middleName:null,surname:"Drago-Serrano",fullName:"Maria Elisa Drago-Serrano",slug:"maria-elisa-drago-serrano",email:"mdrago@correo.xoc.uam.mx",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"74103",title:"Dr.",name:"Laura",middleName:null,surname:"Castrillon Rivera",fullName:"Laura Castrillon Rivera",slug:"laura-castrillon-rivera",email:"lcrivera@correo.xoc.uam.mx",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"Universidad Autónoma Metropolitana",institutionURL:null,country:{name:"Mexico"}}},{id:"208136",title:"Dr.",name:"Jorge Ismael",middleName:null,surname:"Castañeda-Sánchez",fullName:"Jorge Ismael Castañeda-Sánchez",slug:"jorge-ismael-castaneda-sanchez",email:"jcastanedas@correo.xoc.uam.mx",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"253064",title:"Prof.",name:"Alejandro",middleName:null,surname:"Palma Ramos",fullName:"Alejandro Palma Ramos",slug:"alejandro-palma-ramos",email:"alpalma@correo.xoc.uam.mx",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null}],sections:[{id:"sec_1",title:"1. Cultural heritage",level:"1"},{id:"sec_2",title:"2. Biofilms as biodeteriogens",level:"1"},{id:"sec_3",title:"3. Biodeterioration of stone",level:"1"},{id:"sec_4",title:"4. Biodeterioration of paintings",level:"1"},{id:"sec_5",title:"5. Biodeterioration of textiles",level:"1"},{id:"sec_6",title:"6. Biodeterioration of paper and parchments",level:"1"},{id:"sec_7",title:"7. Prevention, conservation, restoration, and control",level:"1"},{id:"sec_8",title:"8. Conclusion",level:"1"}],chapterReferences:[{id:"B1",body:'García Cuetos P. El patrimonio cultural: Conceptos bàsicos. España: Ed. Prensas Universitarias de Zaragoza; 2011. ISBN: 978-84-15274-56-8'},{id:"B2",body:'Patrimonio Cultural: Instituto Andaluz del Patrimonio Histórico. Consejería de Cultura. Available from: www.iaph.es/web/canales/patrimonio-cultural [Accessed: Apr 5, 2018]'},{id:"B3",body:'UNESCO. Patrimonio Indicadores UNESCO de cultura para el Desarrollo. Available from: Vaillant CM. 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Application of bacterial carbonatogenesis to the protection and regeneration of limestones in buildings and historic patrimony. Sedimentary Geology. 1999;126:25-34'},{id:"B104",body:'Rinaldi A. Saving a fragil legacy. EMBO Reports. 2006;11(11):5-1079'},{id:"B105",body:'Zammit G, Sánchez-Moral S, Albertano P. Bacterially mediated mineralisation processes lead to biodeterirarion of artwork in Maltese catacombs. Science of the Total Environment. 2011;409:2773-2782'},{id:"B106",body:'Páramo ALA, Narváez ZJA, Ortega MBO. La bioprecipitación de carbonato de calcio por la biota nativa como método de restauración. Nexo Revista Científica. 2015;28(1):25-40'},{id:"B107",body:'Calvo A. Conservación y restauración de pintura sobre lienzo. In: De la A a la Z, editor. Conservación y Restauración: Materiales Técnicas y Procedimientos. Barcelona: Ed. Serbal; 1997. pp. 152-155. ISBN: 9788476281949'},{id:"B108",body:'Porqué es importante la conservación del patrimonio cultural? Available from: https://sabiendomsdenuestropatrimonio cultural.wordpress.com [Accessed: May 7, 2018]'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Laura E. Castrillón Rivera",address:"lcrivera@correo.xoc.uam.mx",affiliation:'
Departamento de Sistemas Biológicos, Universidad Autónoma Metropolitana, Mexico
Departamento de Sistemas Biológicos, Universidad Autónoma Metropolitana, Mexico
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The public’s response to this extreme event on the social network Twitter is examined using statistical analysis and manual inspection of 185,000 “tweets” relating to Sandy. Sentiment analysis of tweets from Manhattan Island reveals a statistically significant trend toward negative perceptions, especially on the southern half of the island, as Sandy made landfall. Inspection of all tweets uncovered scientific misconceptions regarding hurricanes, and a surprising and disquieting anthropomorphic reconception of Sandy. This reconception, divorced from factual information about the storm, dominated the “Twittersphere” compared to official scientific information. The implications of such reconceptions for social media communication during future extreme events, and the utility of the methodology employed for analysis of other events, are discussed.",signatures:"John A. Knox, Brendan Mazanec, Emily Sullivan, Spencer Hall and\nJared A. Rackley",authors:[{id:"179985",title:"Dr.",name:"John",surname:"Knox",fullName:"John Knox",slug:"john-knox",email:"johnknox@uga.edu"},{id:"180238",title:"Mr.",name:"Brendan",surname:"Mazanec",fullName:"Brendan Mazanec",slug:"brendan-mazanec",email:"bmazanec@uga.edu"},{id:"180239",title:"Ms.",name:"Emily",surname:"Sullivan",fullName:"Emily Sullivan",slug:"emily-sullivan",email:"esulliv4@uga.edu"},{id:"180240",title:"Mr.",name:"Spencer",surname:"Hall",fullName:"Spencer Hall",slug:"spencer-hall",email:"sd77hall@uga.edu"},{id:"180241",title:"M.Sc.",name:"Jared",surname:"Rackley",fullName:"Jared Rackley",slug:"jared-rackley",email:"jrackley@uga.edu"}],book:{id:"5158",title:"Atmospheric Hazards",slug:"atmospheric-hazards-case-studies-in-modeling-communication-and-societal-impacts",productType:{id:"1",title:"Edited Volume"}}}],collaborators:[{id:"15961",title:"Dr.",name:"Kevin",surname:"Law",slug:"kevin-law",fullName:"Kevin Law",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"179023",title:"Mr.",name:"Ronald",surname:"Holle",slug:"ronald-holle",fullName:"Ronald Holle",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"179232",title:"Dr.",name:"Nicolas",surname:"Freychet",slug:"nicolas-freychet",fullName:"Nicolas Freychet",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Academia Sinica",institutionURL:null,country:{name:"Taiwan"}}},{id:"180238",title:"Mr.",name:"Brendan",surname:"Mazanec",slug:"brendan-mazanec",fullName:"Brendan Mazanec",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"180239",title:"Ms.",name:"Emily",surname:"Sullivan",slug:"emily-sullivan",fullName:"Emily Sullivan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"180240",title:"Mr.",name:"Spencer",surname:"Hall",slug:"spencer-hall",fullName:"Spencer Hall",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"183336",title:"Dr.",name:"Mary Ann",surname:"Cooper",slug:"mary-ann-cooper",fullName:"Mary Ann Cooper",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Illinois at Chicago",institutionURL:null,country:{name:"United States of America"}}},{id:"184116",title:"Dr.",name:"Robert",surname:"Schwartz",slug:"robert-schwartz",fullName:"Robert Schwartz",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"184846",title:"Prof.",name:"Huang-Hsiung",surname:"Hsu",slug:"huang-hsiung-hsu",fullName:"Huang-Hsiung Hsu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"184847",title:"Dr.",name:"Chi-Hua",surname:"Wu",slug:"chi-hua-wu",fullName:"Chi-Hua Wu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null}]},generic:{page:{slug:"our-story",title:"Our story",intro:"
The company was founded in Vienna in 2004 by Alex Lazinica and Vedran Kordic, two PhD students researching robotics. While completing our PhDs, we found it difficult to access the research we needed. So, we decided to create a new Open Access publisher. A better one, where researchers like us could find the information they needed easily. The result is IntechOpen, an Open Access publisher that puts the academic needs of the researchers before the business interests of publishers.
",metaTitle:"Our story",metaDescription:"The company was founded in Vienna in 2004 by Alex Lazinica and Vedran Kordic, two PhD students researching robotics. While completing our PhDs, we found it difficult to access the research we needed. So, we decided to create a new Open Access publisher. A better one, where researchers like us could find the information they needed easily. The result is IntechOpen, an Open Access publisher that puts the academic needs of the researchers before the business interests of publishers.",metaKeywords:null,canonicalURL:"/page/our-story",contentRaw:'[{"type":"htmlEditorComponent","content":"
We started by publishing journals and books from the fields of science we were most familiar with - AI, robotics, manufacturing and operations research. Through our growing network of institutions and authors, we soon expanded into related fields like environmental engineering, nanotechnology, computer science, renewable energy and electrical engineering, Today, we are the world’s largest Open Access publisher of scientific research, with over 4,200 books and 54,000 scientific works including peer-reviewed content from more than 116,000 scientists spanning 161 countries. Our authors range from globally-renowned Nobel Prize winners to up-and-coming researchers at the cutting edge of scientific discovery.
\\n\\n
In the same year that IntechOpen was founded, we launched what was at the time the first ever Open Access, peer-reviewed journal in its field: the International Journal of Advanced Robotic Systems (IJARS).
\\n\\n
The IntechOpen timeline
\\n\\n
2004
\\n\\n
\\n\\t
Intech Open is founded in Vienna, Austria, by Alex Lazinica and Vedran Kordic, two PhD students, and their first Open Access journals and books are published.
\\n\\t
Alex and Vedran launch the first Open Access, peer-reviewed robotics journal and IntechOpen’s flagship publication, the International Journal of Advanced Robotic Systems (IJARS).
\\n
\\n\\n
2005
\\n\\n
\\n\\t
IntechOpen publishes its first Open Access book: Cutting Edge Robotics.
\\n
\\n\\n
2006
\\n\\n
\\n\\t
IntechOpen publishes a special issue of IJARS, featuring contributions from NASA scientists regarding the Mars Exploration Rover missions.
\\n
\\n\\n
2008
\\n\\n
\\n\\t
Downloads milestone: 200,000 downloads reached
\\n
\\n\\n
2009
\\n\\n
\\n\\t
Publishing milestone: the first 100 Open Access STM books are published
\\n
\\n\\n
2010
\\n\\n
\\n\\t
Downloads milestone: one million downloads reached
\\n\\t
IntechOpen expands its book publishing into a new field: medicine.
\\n
\\n\\n
2011
\\n\\n
\\n\\t
Publishing milestone: More than five million downloads reached
\\n\\t
IntechOpen publishes 1996 Nobel Prize in Chemistry winner Harold W. Kroto’s “Strategies to Successfully Cross-Link Carbon Nanotubes”. Find it here.
\\n\\t
IntechOpen and TBI collaborate on a project to explore the changing needs of researchers and the evolving ways that they discover, publish and exchange information. The result is the survey “Author Attitudes Towards Open Access Publishing: A Market Research Program”.
\\n\\t
IntechOpen hosts SHOW - Share Open Access Worldwide; a series of lectures, debates, round-tables and events to bring people together in discussion of open source principles, intellectual property, content licensing innovations, remixed and shared culture and free knowledge.
\\n
\\n\\n
2012
\\n\\n
\\n\\t
Publishing milestone: 10 million downloads reached
\\n\\t
IntechOpen holds Interact2012, a free series of workshops held by figureheads of the scientific community including Professor Hiroshi Ishiguro, director of the Intelligent Robotics Laboratory, who took the audience through some of the most impressive human-robot interactions observed in his lab.
\\n
\\n\\n
2013
\\n\\n
\\n\\t
IntechOpen joins the Committee on Publication Ethics (COPE) as part of a commitment to guaranteeing the highest standards of publishing.
\\n
\\n\\n
2014
\\n\\n
\\n\\t
IntechOpen turns 10, with more than 30 million downloads to date.
\\n\\t
IntechOpen appoints its first Regional Representatives - members of the team situated around the world dedicated to increasing the visibility of our authors’ published work within their local scientific communities.
\\n
\\n\\n
2015
\\n\\n
\\n\\t
Downloads milestone: More than 70 million downloads reached, more than doubling since the previous year.
\\n\\t
Publishing milestone: IntechOpen publishes its 2,500th book and 40,000th Open Access chapter, reaching 20,000 citations in Thomson Reuters ISI Web of Science.
\\n\\t
40 IntechOpen authors are included in the top one per cent of the world’s most-cited researchers.
\\n\\t
Thomson Reuters’ ISI Web of Science Book Citation Index begins indexing IntechOpen’s books in its database.
\\n
\\n\\n
2016
\\n\\n
\\n\\t
IntechOpen is identified as a world leader in Simba Information’s Open Access Book Publishing 2016-2020 report and forecast. IntechOpen came in as the world’s largest Open Access book publisher by title count.
\\n
\\n\\n
2017
\\n\\n
\\n\\t
Downloads milestone: IntechOpen reaches more than 100 million downloads
\\n\\t
Publishing milestone: IntechOpen publishes its 3,000th Open Access book, making it the largest Open Access book collection in the world
We started by publishing journals and books from the fields of science we were most familiar with - AI, robotics, manufacturing and operations research. Through our growing network of institutions and authors, we soon expanded into related fields like environmental engineering, nanotechnology, computer science, renewable energy and electrical engineering, Today, we are the world’s largest Open Access publisher of scientific research, with over 4,200 books and 54,000 scientific works including peer-reviewed content from more than 116,000 scientists spanning 161 countries. Our authors range from globally-renowned Nobel Prize winners to up-and-coming researchers at the cutting edge of scientific discovery.
\n\n
In the same year that IntechOpen was founded, we launched what was at the time the first ever Open Access, peer-reviewed journal in its field: the International Journal of Advanced Robotic Systems (IJARS).
\n\n
The IntechOpen timeline
\n\n
2004
\n\n
\n\t
Intech Open is founded in Vienna, Austria, by Alex Lazinica and Vedran Kordic, two PhD students, and their first Open Access journals and books are published.
\n\t
Alex and Vedran launch the first Open Access, peer-reviewed robotics journal and IntechOpen’s flagship publication, the International Journal of Advanced Robotic Systems (IJARS).
\n
\n\n
2005
\n\n
\n\t
IntechOpen publishes its first Open Access book: Cutting Edge Robotics.
\n
\n\n
2006
\n\n
\n\t
IntechOpen publishes a special issue of IJARS, featuring contributions from NASA scientists regarding the Mars Exploration Rover missions.
\n
\n\n
2008
\n\n
\n\t
Downloads milestone: 200,000 downloads reached
\n
\n\n
2009
\n\n
\n\t
Publishing milestone: the first 100 Open Access STM books are published
\n
\n\n
2010
\n\n
\n\t
Downloads milestone: one million downloads reached
\n\t
IntechOpen expands its book publishing into a new field: medicine.
\n
\n\n
2011
\n\n
\n\t
Publishing milestone: More than five million downloads reached
\n\t
IntechOpen publishes 1996 Nobel Prize in Chemistry winner Harold W. Kroto’s “Strategies to Successfully Cross-Link Carbon Nanotubes”. Find it here.
\n\t
IntechOpen and TBI collaborate on a project to explore the changing needs of researchers and the evolving ways that they discover, publish and exchange information. The result is the survey “Author Attitudes Towards Open Access Publishing: A Market Research Program”.
\n\t
IntechOpen hosts SHOW - Share Open Access Worldwide; a series of lectures, debates, round-tables and events to bring people together in discussion of open source principles, intellectual property, content licensing innovations, remixed and shared culture and free knowledge.
\n
\n\n
2012
\n\n
\n\t
Publishing milestone: 10 million downloads reached
\n\t
IntechOpen holds Interact2012, a free series of workshops held by figureheads of the scientific community including Professor Hiroshi Ishiguro, director of the Intelligent Robotics Laboratory, who took the audience through some of the most impressive human-robot interactions observed in his lab.
\n
\n\n
2013
\n\n
\n\t
IntechOpen joins the Committee on Publication Ethics (COPE) as part of a commitment to guaranteeing the highest standards of publishing.
\n
\n\n
2014
\n\n
\n\t
IntechOpen turns 10, with more than 30 million downloads to date.
\n\t
IntechOpen appoints its first Regional Representatives - members of the team situated around the world dedicated to increasing the visibility of our authors’ published work within their local scientific communities.
\n
\n\n
2015
\n\n
\n\t
Downloads milestone: More than 70 million downloads reached, more than doubling since the previous year.
\n\t
Publishing milestone: IntechOpen publishes its 2,500th book and 40,000th Open Access chapter, reaching 20,000 citations in Thomson Reuters ISI Web of Science.
\n\t
40 IntechOpen authors are included in the top one per cent of the world’s most-cited researchers.
\n\t
Thomson Reuters’ ISI Web of Science Book Citation Index begins indexing IntechOpen’s books in its database.
\n
\n\n
2016
\n\n
\n\t
IntechOpen is identified as a world leader in Simba Information’s Open Access Book Publishing 2016-2020 report and forecast. IntechOpen came in as the world’s largest Open Access book publisher by title count.
\n
\n\n
2017
\n\n
\n\t
Downloads milestone: IntechOpen reaches more than 100 million downloads
\n\t
Publishing milestone: IntechOpen publishes its 3,000th Open Access book, making it the largest Open Access book collection in the world
\n
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Applications",isOpenForSubmission:!1,hash:"a3479e76c6ac538aac76409c9efb7e41",slug:"neuroimaging-neurobiology-multimodal-and-network-applications",bookSignature:"Yongxia Zhou",coverURL:"https://cdn.intechopen.com/books/images_new/9347.jpg",editedByType:"Edited by",editors:[{id:"259308",title:"Dr.",name:"Yongxia",middleName:null,surname:"Zhou",slug:"yongxia-zhou",fullName:"Yongxia Zhou"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8938",title:"Inhibitory Control Training",subtitle:"A Multidisciplinary Approach",isOpenForSubmission:!1,hash:"bd82354f3bba4af5421337cd42052f86",slug:"inhibitory-control-training-a-multidisciplinary-approach",bookSignature:"Sara Palermo and Massimo Bartoli",coverURL:"https://cdn.intechopen.com/books/images_new/8938.jpg",editedByType:"Edited by",editors:[{id:"233998",title:"Ph.D.",name:"Sara",middleName:null,surname:"Palermo",slug:"sara-palermo",fullName:"Sara Palermo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6998",title:"Synucleins",subtitle:"Biochemistry and Role in Diseases",isOpenForSubmission:!1,hash:"2b4b802fec508928ce8ab9deebd1375f",slug:"synucleins-biochemistry-and-role-in-diseases",bookSignature:"Andrei Surguchov",coverURL:"https://cdn.intechopen.com/books/images_new/6998.jpg",editedByType:"Edited by",editors:[{id:"266540",title:"Dr.",name:"Andrei",middleName:null,surname:"Surguchov",slug:"andrei-surguchov",fullName:"Andrei Surguchov"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],booksByTopicTotal:65,seriesByTopicCollection:[],seriesByTopicTotal:0,mostCitedChapters:[{id:"46296",doi:"10.5772/57398",title:"Physiological Role of Amyloid Beta in Neural Cells: The Cellular Trophic Activity",slug:"physiological-role-of-amyloid-beta-in-neural-cells-the-cellular-trophic-activity",totalDownloads:5886,totalCrossrefCites:18,totalDimensionsCites:31,abstract:null,book:{id:"3846",slug:"neurochemistry",title:"Neurochemistry",fullTitle:"Neurochemistry"},signatures:"M. del C. Cárdenas-Aguayo, M. del C. Silva-Lucero, M. Cortes-Ortiz,\nB. Jiménez-Ramos, L. Gómez-Virgilio, G. Ramírez-Rodríguez, E. Vera-\nArroyo, R. Fiorentino-Pérez, U. García, J. Luna-Muñoz and M.A.\nMeraz-Ríos",authors:[{id:"42225",title:"Dr.",name:"Jose",middleName:null,surname:"Luna-Muñoz",slug:"jose-luna-munoz",fullName:"Jose Luna-Muñoz"},{id:"114746",title:"Dr.",name:"Marco",middleName:null,surname:"Meraz-Ríos",slug:"marco-meraz-rios",fullName:"Marco Meraz-Ríos"},{id:"169616",title:"Dr.",name:"Maria del Carmen",middleName:null,surname:"Cardenas-Aguayo",slug:"maria-del-carmen-cardenas-aguayo",fullName:"Maria del Carmen Cardenas-Aguayo"},{id:"169857",title:"Dr.",name:"Maria del Carmen",middleName:null,surname:"Silva-Lucero",slug:"maria-del-carmen-silva-lucero",fullName:"Maria del Carmen Silva-Lucero"},{id:"169858",title:"Dr.",name:"Maribel",middleName:null,surname:"Cortes-Ortiz",slug:"maribel-cortes-ortiz",fullName:"Maribel Cortes-Ortiz"},{id:"169859",title:"Dr.",name:"Berenice",middleName:null,surname:"Jimenez-Ramos",slug:"berenice-jimenez-ramos",fullName:"Berenice Jimenez-Ramos"},{id:"169860",title:"Dr.",name:"Laura",middleName:null,surname:"Gomez-Virgilio",slug:"laura-gomez-virgilio",fullName:"Laura Gomez-Virgilio"},{id:"169861",title:"Dr.",name:"Gerardo",middleName:null,surname:"Ramirez-Rodriguez",slug:"gerardo-ramirez-rodriguez",fullName:"Gerardo Ramirez-Rodriguez"},{id:"169862",title:"Dr.",name:"Eduardo",middleName:null,surname:"Vera-Arroyo",slug:"eduardo-vera-arroyo",fullName:"Eduardo Vera-Arroyo"},{id:"169863",title:"Dr.",name:"Rosana Sofia",middleName:null,surname:"Fiorentino-Perez",slug:"rosana-sofia-fiorentino-perez",fullName:"Rosana Sofia Fiorentino-Perez"},{id:"169864",title:"Dr.",name:"Ubaldo",middleName:null,surname:"Garcia",slug:"ubaldo-garcia",fullName:"Ubaldo Garcia"}]},{id:"58070",doi:"10.5772/intechopen.72427",title:"MRI Medical Image Denoising by Fundamental Filters",slug:"mri-medical-image-denoising-by-fundamental-filters",totalDownloads:2564,totalCrossrefCites:17,totalDimensionsCites:30,abstract:"Nowadays Medical imaging technique Magnetic Resonance Imaging (MRI) plays an important role in medical setting to form high standard images contained in the human brain. MRI is commonly used once treating brain, prostate cancers, ankle and foot. The Magnetic Resonance Imaging (MRI) images are usually liable to suffer from noises such as Gaussian noise, salt and pepper noise and speckle noise. So getting of brain image with accuracy is very extremely task. An accurate brain image is very necessary for further diagnosis process. During this chapter, a median filter algorithm will be modified. Gaussian noise and Salt and pepper noise will be added to MRI image. A proposed Median filter (MF), Adaptive Median filter (AMF) and Adaptive Wiener filter (AWF) will be implemented. The filters will be used to remove the additive noises present in the MRI images. The noise density will be added gradually to MRI image to compare performance of the filters evaluation. The performance of these filters will be compared exploitation the applied mathematics parameter Peak Signal-to-Noise Ratio (PSNR).",book:{id:"6144",slug:"high-resolution-neuroimaging-basic-physical-principles-and-clinical-applications",title:"High-Resolution Neuroimaging",fullTitle:"High-Resolution Neuroimaging - Basic Physical Principles and Clinical Applications"},signatures:"Hanafy M. Ali",authors:[{id:"213318",title:"Dr.",name:"Hanafy",middleName:"M.",surname:"Ali",slug:"hanafy-ali",fullName:"Hanafy Ali"}]},{id:"41589",doi:"10.5772/50323",title:"The Role of the Amygdala in Anxiety Disorders",slug:"the-role-of-the-amygdala-in-anxiety-disorders",totalDownloads:9671,totalCrossrefCites:4,totalDimensionsCites:28,abstract:null,book:{id:"2599",slug:"the-amygdala-a-discrete-multitasking-manager",title:"The Amygdala",fullTitle:"The Amygdala - A Discrete Multitasking Manager"},signatures:"Gina L. Forster, Andrew M. Novick, Jamie L. Scholl and Michael J. Watt",authors:[{id:"145620",title:"Dr.",name:"Gina",middleName:null,surname:"Forster",slug:"gina-forster",fullName:"Gina Forster"},{id:"146553",title:"BSc.",name:"Andrew",middleName:null,surname:"Novick",slug:"andrew-novick",fullName:"Andrew Novick"},{id:"146554",title:"MSc.",name:"Jamie",middleName:null,surname:"Scholl",slug:"jamie-scholl",fullName:"Jamie Scholl"},{id:"146555",title:"Dr.",name:"Michael",middleName:null,surname:"Watt",slug:"michael-watt",fullName:"Michael Watt"}]},{id:"26258",doi:"10.5772/28300",title:"Excitotoxicity and Oxidative Stress in Acute Ischemic Stroke",slug:"excitotoxicity-and-oxidative-stress-in-acute-ischemic-stroke",totalDownloads:7157,totalCrossrefCites:6,totalDimensionsCites:25,abstract:null,book:{id:"931",slug:"acute-ischemic-stroke",title:"Acute Ischemic Stroke",fullTitle:"Acute Ischemic Stroke"},signatures:"Ramón Rama Bretón and Julio César García Rodríguez",authors:[{id:"73430",title:"Prof.",name:"Ramon",middleName:null,surname:"Rama",slug:"ramon-rama",fullName:"Ramon Rama"},{id:"124643",title:"Prof.",name:"Julio Cesar",middleName:null,surname:"García",slug:"julio-cesar-garcia",fullName:"Julio Cesar García"}]},{id:"62072",doi:"10.5772/intechopen.78695",title:"Brain-Computer Interface and Motor Imagery Training: The Role of Visual Feedback and Embodiment",slug:"brain-computer-interface-and-motor-imagery-training-the-role-of-visual-feedback-and-embodiment",totalDownloads:1439,totalCrossrefCites:13,totalDimensionsCites:23,abstract:"Controlling a brain-computer interface (BCI) is a difficult task that requires extensive training. Particularly in the case of motor imagery BCIs, users may need several training sessions before they learn how to generate desired brain activity and reach an acceptable performance. A typical training protocol for such BCIs includes execution of a motor imagery task by the user, followed by presentation of an extending bar or a moving object on a computer screen. In this chapter, we discuss the importance of a visual feedback that resembles human actions, the effect of human factors such as confidence and motivation, and the role of embodiment in the learning process of a motor imagery task. Our results from a series of experiments in which users BCI-operated a humanlike android robot confirm that realistic visual feedback can induce a sense of embodiment, which promotes a significant learning of the motor imagery task in a short amount of time. We review the impact of humanlike visual feedback in optimized modulation of brain activity by the BCI users.",book:{id:"6610",slug:"evolving-bci-therapy-engaging-brain-state-dynamics",title:"Evolving BCI Therapy",fullTitle:"Evolving BCI Therapy - Engaging Brain State Dynamics"},signatures:"Maryam Alimardani, Shuichi Nishio and Hiroshi Ishiguro",authors:[{id:"11981",title:"Prof.",name:"Hiroshi",middleName:null,surname:"Ishiguro",slug:"hiroshi-ishiguro",fullName:"Hiroshi Ishiguro"},{id:"231131",title:"Dr.",name:"Maryam",middleName:null,surname:"Alimardani",slug:"maryam-alimardani",fullName:"Maryam Alimardani"},{id:"231134",title:"Dr.",name:"Shuichi",middleName:null,surname:"Nishio",slug:"shuichi-nishio",fullName:"Shuichi Nishio"}]}],mostDownloadedChaptersLast30Days:[{id:"29764",title:"Underlying Causes of Paresthesia",slug:"underlying-causes-of-paresthesia",totalDownloads:192666,totalCrossrefCites:3,totalDimensionsCites:7,abstract:null,book:{id:"1069",slug:"paresthesia",title:"Paresthesia",fullTitle:"Paresthesia"},signatures:"Mahdi Sharif-Alhoseini, Vafa Rahimi-Movaghar and Alexander R. Vaccaro",authors:[{id:"91165",title:"Prof.",name:"Vafa",middleName:null,surname:"Rahimi-Movaghar",slug:"vafa-rahimi-movaghar",fullName:"Vafa Rahimi-Movaghar"}]},{id:"63258",title:"Anatomy and Function of the Hypothalamus",slug:"anatomy-and-function-of-the-hypothalamus",totalDownloads:4558,totalCrossrefCites:6,totalDimensionsCites:12,abstract:"The hypothalamus is a small but important area of the brain formed by various nucleus and nervous fibers. Through its neuronal connections, it is involved in many complex functions of the organism such as vegetative system control, homeostasis of the organism, thermoregulation, and also in adjusting the emotional behavior. The hypothalamus is involved in different daily activities like eating or drinking, in the control of the body’s temperature and energy maintenance, and in the process of memorizing. It also modulates the endocrine system through its connections with the pituitary gland. Precise anatomical description along with a correct characterization of the component structures is essential for understanding its functions.",book:{id:"6331",slug:"hypothalamus-in-health-and-diseases",title:"Hypothalamus in Health and Diseases",fullTitle:"Hypothalamus in Health and Diseases"},signatures:"Miana Gabriela Pop, Carmen Crivii and Iulian Opincariu",authors:null},{id:"57103",title:"GABA and Glutamate: Their Transmitter Role in the CNS and Pancreatic Islets",slug:"gaba-and-glutamate-their-transmitter-role-in-the-cns-and-pancreatic-islets",totalDownloads:3478,totalCrossrefCites:3,totalDimensionsCites:9,abstract:"Glutamate and gamma-aminobutyric acid (GABA) are the major neurotransmitters in the mammalian brain. Inhibitory GABA and excitatory glutamate work together to control many processes, including the brain’s overall level of excitation. The contributions of GABA and glutamate in extra-neuronal signaling are by far less widely recognized. In this chapter, we first discuss the role of both neurotransmitters during development, emphasizing the importance of the shift from excitatory to inhibitory GABAergic neurotransmission. The second part summarizes the biosynthesis and role of GABA and glutamate in neurotransmission in the mature brain, and major neurological disorders associated with glutamate and GABA receptors and GABA release mechanisms. The final part focuses on extra-neuronal glutamatergic and GABAergic signaling in pancreatic islets of Langerhans, and possible associations with type 1 diabetes mellitus.",book:{id:"6237",slug:"gaba-and-glutamate-new-developments-in-neurotransmission-research",title:"GABA And Glutamate",fullTitle:"GABA And Glutamate - New Developments In Neurotransmission Research"},signatures:"Christiane S. Hampe, Hiroshi Mitoma and Mario Manto",authors:[{id:"210220",title:"Prof.",name:"Christiane",middleName:null,surname:"Hampe",slug:"christiane-hampe",fullName:"Christiane Hampe"},{id:"210485",title:"Prof.",name:"Mario",middleName:null,surname:"Manto",slug:"mario-manto",fullName:"Mario Manto"},{id:"210486",title:"Prof.",name:"Hiroshi",middleName:null,surname:"Mitoma",slug:"hiroshi-mitoma",fullName:"Hiroshi Mitoma"}]},{id:"35802",title:"Cross-Cultural/Linguistic Differences in the Prevalence of Developmental Dyslexia and the Hypothesis of Granularity and Transparency",slug:"cross-cultural-linguistic-differences-in-the-prevalence-of-developmental-dyslexia-and-the-hypothesis",totalDownloads:3601,totalCrossrefCites:2,totalDimensionsCites:7,abstract:null,book:{id:"673",slug:"dyslexia-a-comprehensive-and-international-approach",title:"Dyslexia",fullTitle:"Dyslexia - A Comprehensive and International Approach"},signatures:"Taeko N. Wydell",authors:[{id:"87489",title:"Prof.",name:"Taeko",middleName:"N.",surname:"Wydell",slug:"taeko-wydell",fullName:"Taeko Wydell"}]},{id:"58597",title:"Testosterone and Erectile Function: A Review of Evidence from Basic Research",slug:"testosterone-and-erectile-function-a-review-of-evidence-from-basic-research",totalDownloads:1331,totalCrossrefCites:2,totalDimensionsCites:2,abstract:"Androgens are essential for male physical activity and normal erectile function. Hence, age-related testosterone deficiency, known as late-onset hypogonadism (LOH), is considered a risk factor for erectile dysfunction (ED). This chapter summarizes relevant basic research reports examining the effects of testosterone on erectile function. Testosterone affects several organs and is especially active on the erectile tissue. The mechanism of testosterone deficiency effects on erectile function and the results of testosterone replacement therapy (TRT) have been well studied. Testosterone affects nitric oxide (NO) production and phosphodiesterase type 5 (PDE-5) expression in the corpus cavernosum through molecular pathways, preserves smooth muscle contractility by regulating both contraction and relaxation, and maintains the structure of the corpus cavernosum. Interestingly, testosterone deficiency has relationship to neurological diseases, which leads to ED. Testosterone replacement therapy is widely used to treat patients with testosterone deficiency; however, this treatment might also induce some problems. Basic research suggests that PDE-5 inhibitors, L-citrulline, and/or resveratrol therapy might be effective therapeutic options for testosterone deficiency-induced ED. Future research should confirm these findings through more specific experiments using molecular tools and may shed more light on endocrine-related ED and its possible treatments.",book:{id:"5994",slug:"sex-hormones-in-neurodegenerative-processes-and-diseases",title:"Sex Hormones in Neurodegenerative Processes and Diseases",fullTitle:"Sex Hormones in Neurodegenerative Processes and Diseases"},signatures:"Tomoya Kataoka and Kazunori Kimura",authors:[{id:"219042",title:"Ph.D.",name:"Tomoya",middleName:null,surname:"Kataoka",slug:"tomoya-kataoka",fullName:"Tomoya Kataoka"},{id:"229066",title:"Prof.",name:"Kazunori",middleName:null,surname:"Kimura",slug:"kazunori-kimura",fullName:"Kazunori Kimura"}]}],onlineFirstChaptersFilter:{topicId:"18",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"81646",title:"Cortical Plasticity under Ketamine: From Synapse to Map",slug:"cortical-plasticity-under-ketamine-from-synapse-to-map",totalDownloads:15,totalDimensionsCites:0,doi:"10.5772/intechopen.104787",abstract:"Sensory systems need to process signals in a highly dynamic way to efficiently respond to variations in the animal’s environment. For instance, several studies showed that the visual system is subject to neuroplasticity since the neurons’ firing changes according to stimulus properties. This dynamic information processing might be supported by a network reorganization. Since antidepressants influence neurotransmission, they can be used to explore synaptic plasticity sustaining cortical map reorganization. To this goal, we investigated in the primary visual cortex (V1 of mouse and cat), the impact of ketamine on neuroplasticity through changes in neuronal orientation selectivity and the functional connectivity between V1 cells, using cross correlation analyses. We found that ketamine affects cortical orientation selectivity and alters the functional connectivity within an assembly. These data clearly highlight the role of the antidepressant drugs in inducing or modeling short-term plasticity in V1 which suggests that cortical processing is optimized and adapted to the properties of the stimulus.",book:{id:"11374",title:"Sensory Nervous System - Computational Neuroimaging Investigations of Topographical Organization in Human Sensory Cortex",coverURL:"https://cdn.intechopen.com/books/images_new/11374.jpg"},signatures:"Ouelhazi Afef, Rudy Lussiez and Molotchnikoff Stephane"},{id:"81582",title:"The Role of Cognitive Reserve in Executive Functioning and Its Relationship to Cognitive Decline and Dementia",slug:"the-role-of-cognitive-reserve-in-executive-functioning-and-its-relationship-to-cognitive-decline-and",totalDownloads:23,totalDimensionsCites:0,doi:"10.5772/intechopen.104646",abstract:"In this chapter, we explore how cognitive reserve is implicated in coping with the negative consequences of brain pathology and age-related cognitive decline. Individual differences in cognitive performance are based on different brain mechanisms (neural reserve and neural compensation), and reflect, among others, the effect of education, occupational attainment, leisure activities, and social involvement. These cognitive reserve proxies have been extensively associated with efficient executive functioning. We discuss and focus particularly on the compensation mechanisms related to the frontal lobe and its protective role, in maintaining cognitive performance in old age or even mitigating the clinical expression of dementia.",book:{id:"11742",title:"Neurophysiology",coverURL:"https://cdn.intechopen.com/books/images_new/11742.jpg"},signatures:"Gabriela Álvares-Pereira, Carolina Maruta and Maria Vânia Silva-Nunes"},{id:"81488",title:"Aggression and Sexual Behavior: Overlapping or Distinct Roles of 5-HT1A and 5-HT1B Receptors",slug:"aggression-and-sexual-behavior-overlapping-or-distinct-roles-of-5-ht1a-and-5-ht1b-receptors",totalDownloads:19,totalDimensionsCites:0,doi:"10.5772/intechopen.104872",abstract:"Distinct brain mechanisms for male aggressive and sexual behavior are present in mammalian species, including man. However, recent evidence suggests a strong connection and even overlap in the central nervous system (CNS) circuitry involved in aggressive and sexual behavior. The serotonergic system in the CNS is strongly involved in male aggressive and sexual behavior. In particular, 5-HT1A and 5-HT1B receptors seem to play a critical role in the modulation of these behaviors. The present chapter focuses on the effects of 5-HT1A- and 5-HT1B-receptor ligands in male rodent aggression and sexual behavior. Results indicate that 5-HT1B-heteroreceptors play a critical role in the modulation of male offensive behavior, although a definite role of 5-HT1A-auto- or heteroreceptors cannot be ruled out. 5-HT1A receptors are clearly involved in male sexual behavior, although it has to be yet unraveled whether 5-HT1A-auto- or heteroreceptors are important. Although several key nodes in the complex circuitry of aggression and sexual behavior are known, in particular in the medial hypothalamus, a clear link or connection to these critical structures and the serotonergic key receptors is yet to be determined. This information is urgently needed to detect and develop new selective anti-aggressive (serenic) and pro-sexual drugs for human applications.",book:{id:"10195",title:"Serotonin and the CNS - New Developments in Pharmacology and Therapeutics",coverURL:"https://cdn.intechopen.com/books/images_new/10195.jpg"},signatures:"Berend Olivier and Jocelien D.A. Olivier"},{id:"81093",title:"Prehospital and Emergency Room Airway Management in Traumatic Brain Injury",slug:"prehospital-and-emergency-room-airway-management-in-traumatic-brain-injury",totalDownloads:49,totalDimensionsCites:0,doi:"10.5772/intechopen.104173",abstract:"Airway management in trauma is critical and may impact patient outcomes. Particularly in traumatic brain injury (TBI), depressed level of consciousness may be associated with compromised protective airway reflexes or apnea, which can increase the risk of aspiration or result in hypoxemia and worsen the secondary brain damage. Therefore, patients with TBI and Glasgow Coma Scale (GCS) ≤ 8 have been traditionally managed by prehospital or emergency room (ER) endotracheal intubation. However, recent evidence challenged this practice and even suggested that routine intubation may be harmful. This chapter will address the indications and optimal method of securing the airway, prehospital and in the ER, in patients with traumatic brain injury.",book:{id:"11367",title:"Traumatic Brain Injury",coverURL:"https://cdn.intechopen.com/books/images_new/11367.jpg"},signatures:"Dominik A. Jakob, Jean-Cyrille Pitteloud and Demetrios Demetriades"},{id:"81011",title:"Amino Acids as Neurotransmitters. The Balance between Excitation and Inhibition as a Background for Future Clinical Applications",slug:"amino-acids-as-neurotransmitters-the-balance-between-excitation-and-inhibition-as-a-background-for-f",totalDownloads:19,totalDimensionsCites:0,doi:"10.5772/intechopen.103760",abstract:"For more than 30 years, amino acids have been well-known (and essential) participants in neurotransmission. They act as both neuromediators and metabolites in nervous tissue. Glycine and glutamic acid (glutamate) are prominent examples. These amino acids are agonists of inhibitory and excitatory membrane receptors, respectively. Moreover, they play essential roles in metabolic pathways and energy transformation in neurons and astrocytes. Despite their obvious effects on the brain, their potential role in therapeutic methods remains uncertain in clinical practice. In the current chapter, a comparison of the crosstalk between these two systems, which are responsible for excitation and inhibition in neurons, is presented. The interactions are discussed at the metabolic, receptor, and transport levels. Reaction-diffusion and a convectional flow into the interstitial fluid create a balanced distribution of glycine and glutamate. Indeed, the neurons’ final physiological state is a result of a balance between the excitatory and inhibitory influences. However, changes to the glycine and/or glutamate pools under pathological conditions can alter the state of nervous tissue. Thus, new therapies for various diseases may be developed on the basis of amino acid medication.",book:{id:"10890",title:"Recent Advances in Neurochemistry",coverURL:"https://cdn.intechopen.com/books/images_new/10890.jpg"},signatures:"Yaroslav R. Nartsissov"},{id:"80821",title:"Neuroimmunology and Neurological Manifestations of COVID-19",slug:"neuroimmunology-and-neurological-manifestations-of-covid-19",totalDownloads:41,totalDimensionsCites:0,doi:"10.5772/intechopen.103026",abstract:"Infection with SARS-CoV-2 is causing coronavirus disease in 2019 (COVID-19). Besides respiratory symptoms due to an attack on the broncho-alveolar system, COVID-19, among others, can be accompanied by neurological symptoms because of the affection of the nervous system. These can be caused by intrusion by SARS-CoV-2 of the central nervous system (CNS) and peripheral nervous system (PNS) and direct infection of local cells. In addition, neurological deterioration mediated by molecular mimicry to virus antigens or bystander activation in the context of immunological anti-virus defense can lead to tissue damage in the CNS and PNS. In addition, cytokine storm caused by SARS-CoV-2 infection in COVID-19 can lead to nervous system related symptoms. Endotheliitis of CNS vessels can lead to vessel occlusion and stroke. COVID-19 can also result in cerebral hemorrhage and sinus thrombosis possibly related to changes in clotting behavior. Vaccination is most important to prevent COVID-19 in the nervous system. There are symptomatic or/and curative therapeutic approaches to combat COVID-19 related nervous system damage that are partly still under study.",book:{id:"10890",title:"Recent Advances in Neurochemistry",coverURL:"https://cdn.intechopen.com/books/images_new/10890.jpg"},signatures:"Robert Weissert"}],onlineFirstChaptersTotal:17},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:0,limit:8,total:null},allSeries:{pteSeriesList:[],lsSeriesList:[],hsSeriesList:[],sshSeriesList:[],testimonialsList:[]},series:{item:{id:"25",title:"Environmental Sciences",doi:"10.5772/intechopen.100362",issn:"2754-6713",scope:"
\r\n\tScientists have long researched to understand the environment and man’s place in it. The search for this knowledge grows in importance as rapid increases in population and economic development intensify humans’ stresses on ecosystems. Fortunately, rapid increases in multiple scientific areas are advancing our understanding of environmental sciences. Breakthroughs in computing, molecular biology, ecology, and sustainability science are enhancing our ability to utilize environmental sciences to address real-world problems. \r\n\tThe four topics of this book series - Pollution; Environmental Resilience and Management; Ecosystems and Biodiversity; and Water Science - will address important areas of advancement in the environmental sciences. They will represent an excellent initial grouping of published works on these critical topics.
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Dr. Summers is a systems ecologist and began his career at the EPA in 1989 and has worked in various programs and capacities. This includes leading the National Coastal Assessment in collaboration with the Office of Water which culminated in the award-winning National Coastal Condition Report series (four volumes between 2001 and 2012), and which integrates water quality, sediment quality, habitat, and biological data to assess the ecosystem condition of the United States estuaries. He was acting National Program Director for Ecology for the EPA between 2004 and 2006. He has authored approximately 150 peer-reviewed journal articles, book chapters, and reports and has received many awards for technical accomplishments from the EPA and from outside of the agency. 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