IntechOpen was founded by scientists, for scientists, in order to make book publishing accessible around the globe. Over the last two decades, this has driven Open Access (OA) book publishing whilst levelling the playing field for global academics. Through our innovative publishing model and the support of the research community, we have now published over 5,700 Open Access books and are visited online by over three million academics every month. These researchers are increasingly working in broad technology-based subjects, driving multidisciplinary academic endeavours into human health, environment, and technology.
\\n\\n
By listening to our community, and in order to serve these rapidly growing areas which lie at the core of IntechOpen's expertise, we are launching a portfolio of Open Science journals:
All three journals will publish under an Open Access model and embrace Open Science policies to help support the changing needs of academics in these fast-moving research areas. There will be direct links to preprint servers and data repositories, allowing full reproducibility and rapid dissemination of published papers to help accelerate the pace of research. Each journal has renowned Editors in Chief who will work alongside a global Editorial Board, delivering robust single-blind peer review. Supported by our internal editorial teams, this will ensure our authors will receive a quick, user-friendly, and personalised publishing experience.
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"By launching our journals portfolio we are introducing new, dedicated homes for interdisciplinary technology-focused researchers to publish their work, whilst embracing Open Science and creating a unique global home for academics to disseminate their work. We are taking a leap toward Open Science continuing and expanding our fundamental commitment to openly sharing scientific research across the world, making it available for the benefit of all." Dr. Sara Uhac, IntechOpen CEO
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"Our aim is to promote and create better science for a better world by increasing access to information and the latest scientific developments to all scientists, innovators, entrepreneurs and students and give them the opportunity to learn, observe and contribute to knowledge creation. Open Science promotes a swifter path from research to innovation to produce new products and services." Alex Lazinica, IntechOpen founder
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In conclusion, Natalia Reinic Babic, Head of Journal Publishing and Open Science at IntechOpen adds:
\\n\\n
“On behalf of the journal team I’d like to thank all our Editors in Chief, Editorial Boards, internal supporting teams, and our scientific community for their continuous support in making this portfolio a reality - we couldn’t have done it without you! With your support in place, we are confident these journals will become as impactful and successful as our book publishing program and bring us closer to a more open (science) future.”
\\n\\n
We invite you to visit the journals homepage and learn more about the journal’s Editorial Boards, scope and vision as all three journals are now open for submissions.
\\n\\n
Feel free to share this news on social media and help us mark this memorable moment!
After years of being acknowledged as the world's leading publisher of Open Access books, today, we are proud to announce we’ve successfully launched a portfolio of Open Science journals covering rapidly expanding areas of interdisciplinary research.
\n\n\n\n
IntechOpen was founded by scientists, for scientists, in order to make book publishing accessible around the globe. Over the last two decades, this has driven Open Access (OA) book publishing whilst levelling the playing field for global academics. Through our innovative publishing model and the support of the research community, we have now published over 5,700 Open Access books and are visited online by over three million academics every month. These researchers are increasingly working in broad technology-based subjects, driving multidisciplinary academic endeavours into human health, environment, and technology.
\n\n
By listening to our community, and in order to serve these rapidly growing areas which lie at the core of IntechOpen's expertise, we are launching a portfolio of Open Science journals:
All three journals will publish under an Open Access model and embrace Open Science policies to help support the changing needs of academics in these fast-moving research areas. There will be direct links to preprint servers and data repositories, allowing full reproducibility and rapid dissemination of published papers to help accelerate the pace of research. Each journal has renowned Editors in Chief who will work alongside a global Editorial Board, delivering robust single-blind peer review. Supported by our internal editorial teams, this will ensure our authors will receive a quick, user-friendly, and personalised publishing experience.
\n\n
"By launching our journals portfolio we are introducing new, dedicated homes for interdisciplinary technology-focused researchers to publish their work, whilst embracing Open Science and creating a unique global home for academics to disseminate their work. We are taking a leap toward Open Science continuing and expanding our fundamental commitment to openly sharing scientific research across the world, making it available for the benefit of all." Dr. Sara Uhac, IntechOpen CEO
\n\n
"Our aim is to promote and create better science for a better world by increasing access to information and the latest scientific developments to all scientists, innovators, entrepreneurs and students and give them the opportunity to learn, observe and contribute to knowledge creation. Open Science promotes a swifter path from research to innovation to produce new products and services." Alex Lazinica, IntechOpen founder
\n\n
In conclusion, Natalia Reinic Babic, Head of Journal Publishing and Open Science at IntechOpen adds:
\n\n
“On behalf of the journal team I’d like to thank all our Editors in Chief, Editorial Boards, internal supporting teams, and our scientific community for their continuous support in making this portfolio a reality - we couldn’t have done it without you! With your support in place, we are confident these journals will become as impactful and successful as our book publishing program and bring us closer to a more open (science) future.”
\n\n
We invite you to visit the journals homepage and learn more about the journal’s Editorial Boards, scope and vision as all three journals are now open for submissions.
\n\n
Feel free to share this news on social media and help us mark this memorable moment!
\n\n
\n'}],latestNews:[{slug:"intechopen-supports-asapbio-s-new-initiative-publish-your-reviews-20220729",title:"IntechOpen Supports ASAPbio’s New Initiative Publish Your Reviews"},{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"}]},book:{item:{type:"book",id:"5612",leadTitle:null,fullTitle:"Aromatic and Medicinal Plants - Back to Nature",title:"Aromatic and Medicinal Plants",subtitle:"Back to Nature",reviewType:"peer-reviewed",abstract:"This book covers interesting research topics and the use of natural resources for medical treatments in some severe diseases. The most important message is to have native foods which contain high amount of active compounds that can be used as a medicinal plant. Most pharmaceutical drugs were discovered from plants, and still ongoing research will have to predict such new active compounds as anti-diseases. I do believe this book will add significant knowledge to medical societies as well as can be used for postgraduate students.",isbn:"978-953-51-2978-3",printIsbn:"978-953-51-2977-6",pdfIsbn:"978-953-51-7348-9",doi:"10.5772/63696",price:119,priceEur:129,priceUsd:155,slug:"aromatic-and-medicinal-plants-back-to-nature",numberOfPages:298,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"ccf7987200bfc541e2e56bb138de86f3",bookSignature:"Hany A. El-Shemy",publishedDate:"March 15th 2017",coverURL:"https://cdn.intechopen.com/books/images_new/5612.jpg",numberOfDownloads:47074,numberOfWosCitations:74,numberOfCrossrefCitations:69,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:150,numberOfDimensionsCitationsByBook:0,hasAltmetrics:1,numberOfTotalCitations:293,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"June 2nd 2016",dateEndSecondStepPublish:"June 23rd 2016",dateEndThirdStepPublish:"September 19th 2016",dateEndFourthStepPublish:"December 18th 2016",dateEndFifthStepPublish:"February 16th 2017",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"54719",title:"Prof.",name:"Hany",middleName:null,surname:"El-Shemy",slug:"hany-el-shemy",fullName:"Hany El-Shemy",profilePictureURL:"https://mts.intechopen.com/storage/users/54719/images/system/54719.jpg",biography:"Prof. Hany A. El-Shemy received a Ph.D. in Biochemistry from the University of Cairo, Egypt, and a Ph.D. in Genetic Engineering from the University of Hiroshima, Japan. He holds two patents and has written thirteen international books. He has also published more than 100 SCI journal papers and 55 conference presentations. Dr. El-Shemy was a technique committee member as well as chair of many international conferences. He has also served as editor for journals including PLOS ONE, BMC Genomics, and Current Issues in Molecular Biology. He has received several awards, including state prizes from the Academy of Science, Egypt (2004, 2012, and 2018), the Young Arab Researcher prize from the Shuman Foundation, Jordan (2005), and Cairo University Prizes (2007, 2010, and 2014). He served as an expert for the African Regional Center of Technology, Dakar, Senegal, as well as a visiting professor at Pan African University, African Union. He served as vice president of the Academy of Science and Technology, Egypt, from 2013 to 2014. Since 2014 he has been the dean of the Faculty of Agriculture, Cairo University. In 2018, he was elected a fellow of the African Academy of Science.",institutionString:"Cairo University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"13",institution:{name:"Cairo University",institutionURL:null,country:{name:"Egypt"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"991",title:"Herbalism",slug:"herbalism"}],chapters:[{id:"53735",title:"Medicinal Plants to Calm and Treat Psoriasis Disease",doi:"10.5772/67062",slug:"medicinal-plants-to-calm-and-treat-psoriasis-disease",totalDownloads:2640,totalCrossrefCites:5,totalDimensionsCites:12,hasAltmetrics:1,abstract:"Psoriasis is a chronic and inflammatory multifactorial disease. For psoriasis treatment, topical chemical agents are applied, in spite of inefficient effects or less effectiveness. But medical plants can be one of the alternative treatment methods. In the field, herbal creams are the most used. In fact, they are helping to inhibit leukotriene formation, inflammation and blocks cyclooxygenase enzymes, then heal skin wounds due to the plant's flavonoids and tannins. The aim of this study is the making of new herbal cream for treating psoriasis. In the mentioned cream, synergistic effects of medicinal herbals extracts were evaluate on damaged skin. Some of these extracts include Santalum album, Arctium lappa, Matricaria chamomilla, Glycyrrhiza glabra, Lavandula angustifolia, Avena sativa, Aloe barbadesis, Pinus eldarica and Cydonia seed‐Mucus. Cream was prepared by mixing water‐in‐oil (W/O) and was proposed to five patients who suffer from psoriasis. Results were remarkable. All five patients were satisfied from itching inhibition and skin inflammation in first week. After 2 weeks applying cream, fading skin redness and increasing skin flexibility and repair were noticeable. An important point in this cream was the mixed herbal extract with high effectiveness than each of them alone. In fact, S. album and L. angustifolia were caused softening of skin corneous layer. Flavonoids and tannins in G. glabra, A. lappa, P. eldarica and A. sativa are effective for treating skin lesions such as psoriasis. Polysaccharides in A. barbadensis and mucilage in C. seed‐Mucus not only are healing skin wounds but also their malic acid make peeling skin dead cells. Moreover, pectin and provitamins (A) act as antioxidants and prevent damage of skin healthy cells. Herbal β‐sitosterols are factor of fading skin redness and anti‐itching, a‐bisabolol (M. chamomilla) as anti‐inflammation; blocks cyclooxygenase enzymes and inhibits leukotriene formation to prevent redness. In fact, this treatment cream is effective for collagen synthesis, wound improvement, epidermal‐moisture maintenance, inflammation relief and boost immune system and will inhibit psoriasis common symptoms in shortest time and no side effect.",signatures:"Azadeh Izadyari Aghmiuni and Azim Akbarzadeh Khiavi",downloadPdfUrl:"/chapter/pdf-download/53735",previewPdfUrl:"/chapter/pdf-preview/53735",authors:[{id:"193310",title:"Dr.",name:"Azadeh",surname:"Izadyari Aghmiuni",slug:"azadeh-izadyari-aghmiuni",fullName:"Azadeh Izadyari Aghmiuni"},{id:"194012",title:"Prof.",name:"Azim",surname:"Akbarzadeh Khyavi",slug:"azim-akbarzadeh-khyavi",fullName:"Azim Akbarzadeh Khyavi"}],corrections:null},{id:"53014",title:"Cardiac Glycosides in Medicinal Plants",doi:"10.5772/65963",slug:"cardiac-glycosides-in-medicinal-plants",totalDownloads:5819,totalCrossrefCites:12,totalDimensionsCites:18,hasAltmetrics:0,abstract:"Plant active metabolites are under intensive examinations around the world to supplement the drugs with minimal side effects. Thus, there is vast potential to explore the possible medicine from the plant sources. Cardiac glycosides are a unique group of secondary metabolites that they are considered one of the most useful drugs in therapeutics. In this review, cardiac glycosides and their analogues are presented. The structure and distribution in plants, as well as structure elucidations, synthetic routes, and chemical analysis, are shown. In addition, the pharmacological activities, mode of action studies, and structureactivity relationships are discussed.",signatures:"Nagy Morsy",downloadPdfUrl:"/chapter/pdf-download/53014",previewPdfUrl:"/chapter/pdf-preview/53014",authors:[{id:"193379",title:"Dr.",name:"Nagy",surname:"Morsy",slug:"nagy-morsy",fullName:"Nagy Morsy"}],corrections:null},{id:"54028",title:"Chemical Composition and Biological Activities of Mentha Species",doi:"10.5772/67291",slug:"chemical-composition-and-biological-activities-of-mentha-species",totalDownloads:7531,totalCrossrefCites:13,totalDimensionsCites:50,hasAltmetrics:0,abstract:"The genus Mentha L. (Lamiaceae) is distributed all over the world and can be found in many environments. Mentha species, one of the world’s oldest and most popular herbs, are widely used in cooking, in cosmetics, and as alternative or complementary therapy, mainly for the treatment of gastrointestinal disorders like flatulence, indigestion, nausea, vomiting, anorexia, and ulcerative colitis. Furthermore, it is well documented that the essential oil and extracts of Mentha species possess antimicrobial, fungicidal, antiviral, insecticidal, and antioxidant properties. The economic importance of mints is also evident; mint oil and its constituents and derivatives are used as flavoring agents throughout the world in food, pharmaceutical, herbal, perfumery, and flavoring industry. To provide a scientific basis for their traditional uses, several studies have been conducted to determine the chemical composition of mints and assess their biological activities. This chapter describes the therapeutic effects and uses of Mentha species and their constituents, particularly essential oils and phenolic compounds; some additional biological activities will also be considered.",signatures:"Fatiha Brahmi, Madani Khodir, Chibane Mohamed and Duez Pierre",downloadPdfUrl:"/chapter/pdf-download/54028",previewPdfUrl:"/chapter/pdf-preview/54028",authors:[{id:"193281",title:"Dr.",name:"Fatiha",surname:"Brahmi",slug:"fatiha-brahmi",fullName:"Fatiha Brahmi"},{id:"199693",title:"Prof.",name:"Khodir",surname:"Madani",slug:"khodir-madani",fullName:"Khodir Madani"},{id:"199694",title:"Prof.",name:"Pierre",surname:"Duez",slug:"pierre-duez",fullName:"Pierre Duez"},{id:"203738",title:"Prof.",name:"Mohamed",surname:"Chibane",slug:"mohamed-chibane",fullName:"Mohamed Chibane"}],corrections:[{id:"57158",title:"Correction to: Chemical Composition and Biological Activities of Mentha Species",doi:null,slug:"correction-to-chemical-composition-and-biological-activities-of-mentha-species",totalDownloads:null,totalCrossrefCites:null,correctionPdfUrl:null}]},{id:"53244",title:"Biological Properties of Essential Oils from the Piper Species of Brazil: A Review",doi:"10.5772/66508",slug:"biological-properties-of-essential-oils-from-the-piper-species-of-brazil-a-review",totalDownloads:2397,totalCrossrefCites:2,totalDimensionsCites:9,hasAltmetrics:0,abstract:"Piperaceae, a Latin name derived from Greek, which in turn originates from the Arabic word babary—black pepper, is considered one of the largest families of basal dicots, found in tropical and subtropical regions of both hemispheres. The species that belong to this family have a primarily pantropical distribution, predominantly herbaceous members, occurring in tropical Africa, tropical Asia, Central America and the Amazon region. The Piperaceae family includes five genera: Piper, Peperomia, Manekia, Zippelia and Verhuellia. Brazil has about 500 species distributed in the Piper, Peperomia and Manekia genera. The Piper genus, the largest of the Piperaceae family, has about 4000 species. Within the Piper genus, about 260–450 species can be found in Brazil. Piper species have diverse biological activities and are used in pharmacopeia throughout the world. They are also used in folk medicine for treatment of many diseases in several countries including Brazil, China, India, Jamaica and Mexico. Pharmacological studies of Piper species point toward the vast potential of these plants to treat various diseases. Many of these species are biologically active and have shown antitumor, antimicrobial, antioxidant, insecticidal, anti-inflammatory, antinociceptive, enzyme inhibitor, antiparasitic, antiplatelet, piscicide, allelopathic, antiophidic, anxiolytic, antidepressant, antidiabetic, hepatoprotective, amebicide and diuretic possibilities.",signatures:"Renata Takeara, Regiane Gonçalves, Vanessa Farias dos Santos\nAyres and Anderson Cavalcante Guimarães",downloadPdfUrl:"/chapter/pdf-download/53244",previewPdfUrl:"/chapter/pdf-preview/53244",authors:[{id:"193541",title:"Dr.",name:"Renata",surname:"Takeara",slug:"renata-takeara",fullName:"Renata Takeara"},{id:"193600",title:"BSc.",name:"Vanessa F. S.",surname:"Ayres",slug:"vanessa-f.-s.-ayres",fullName:"Vanessa F. S. Ayres"},{id:"193601",title:"Prof.",name:"Anderson C.",surname:"Guimarães",slug:"anderson-c.-guimaraes",fullName:"Anderson C. Guimarães"},{id:"194169",title:"BSc.",name:"Regiane",surname:"Gonçalves",slug:"regiane-goncalves",fullName:"Regiane Gonçalves"}],corrections:null},{id:"53310",title:"Culture, History and Applications of Medicinal and Aromatic Plants in Japan",doi:"10.5772/66505",slug:"culture-history-and-applications-of-medicinal-and-aromatic-plants-in-japan",totalDownloads:2903,totalCrossrefCites:6,totalDimensionsCites:12,hasAltmetrics:0,abstract:"Historically, the Japanese began to use aromatic and medicinal plants for ritual activities, food flavor, and treatment of their bodies. The exotic plants, new ideas, and culture associated with medicinal and aromatic plants were introduced to Japan from other countries, primarily via Korea. In this way, experience and knowledge of uses were accumulated, and applications of aromatic and medicinal plants were expanded. The oldest Japanese medicine “Wa ho” leads the way to folk medicine today, and traditional Japanese medicine (Kampo) has spread into modern use. The elegance tradition of “Kodo,” an incense ceremony of Japan, was developed because of the use of aromatic incensed wood in sixteenth century as recreation. Paired along with this ceremony is the Japanese sa-do tea ceremony that the spirituality and esthetic sense are inherited to Japanese today. Japanese green tea is becoming popular in many countries due to the constituent, catechins, that medically treats vascular disease, several cancers, and type II diabetes. Today, the Japanese medical system has new direction, integrating medicine with the adoption of modern western and alternative medicine. Scientific data must continue to be collected for interactions between the two medicinal systems for integrative medicine to be ideal for body, mind, and spirit of humans and nature.",signatures:"Maiko Inoue, Shinichiro Hayashi and Lyle E. Craker",downloadPdfUrl:"/chapter/pdf-download/53310",previewPdfUrl:"/chapter/pdf-preview/53310",authors:[{id:"193395",title:"Ph.D.",name:"Maiko",surname:"Inoue",slug:"maiko-inoue",fullName:"Maiko Inoue"},{id:"196850",title:"BSc.",name:"Shinichiro",surname:"Hayashi",slug:"shinichiro-hayashi",fullName:"Shinichiro Hayashi"},{id:"196853",title:"Prof.",name:"Lyle",surname:"Craker",slug:"lyle-craker",fullName:"Lyle Craker"}],corrections:null},{id:"53226",title:"Meeting of the Minds: Traditional Herbal Medicine in Multiethnic Suriname",doi:"10.5772/66509",slug:"meeting-of-the-minds-traditional-herbal-medicine-in-multiethnic-suriname",totalDownloads:2057,totalCrossrefCites:8,totalDimensionsCites:11,hasAltmetrics:0,abstract:"The Republic of Suriname (South America) is located on the Guiana Shield, one of the regions with the highest biodiversity and the largest expanse of undisturbed tropical rain forest in the world. The population of almost 570,000 consists of a unique blend of ethnic groups and cultures from all continents. These include Indigenous Amerindians, the original inhabitants; Maroons, the descendants of runaway slaves who had been shipped from Africa between the seventeenth and the nineteenth century; Creoles, a generic term referring to mixed blacks and whites; the descendants from indentured workers from China, India, and Java (Indonesia) who arrived between the second half of the nineteenth and the first half of the twentieth century; as well as immigrants from various Middle Eastern, European, Caribbean, and South American countries. All these groups have made their own specific contribution to Suriname’s traditional medicine, which has resulted in a myriad of remedies against many disorders, mainly employing a variety of plants. This chapter presents a brief history of Suriname, addresses the ethnopharmacological practices of Maroons and Creoles as well as Hindustanis and Javanese, and concludes with a few remarks on the previsions provided by the country’s rich plant-based traditional medicine.",signatures:"Dennis R.A. Mans, Deeksha Ganga and Joëlle Kartopawiro",downloadPdfUrl:"/chapter/pdf-download/53226",previewPdfUrl:"/chapter/pdf-preview/53226",authors:[{id:"193905",title:"Dr.",name:"Dennis",surname:"R.A. Mans",slug:"dennis-r.a.-mans",fullName:"Dennis R.A. Mans"},{id:"193909",title:"Dr.",name:"Joelle",surname:"Kartopawiro",slug:"joelle-kartopawiro",fullName:"Joelle Kartopawiro"},{id:"193910",title:"MSc.",name:"Deeksha",surname:"Ganga",slug:"deeksha-ganga",fullName:"Deeksha Ganga"}],corrections:null},{id:"53285",title:"Aromatic and Medicinal Plants in Mexico",doi:"10.5772/66507",slug:"aromatic-and-medicinal-plants-in-mexico",totalDownloads:2431,totalCrossrefCites:3,totalDimensionsCites:6,hasAltmetrics:0,abstract:"Medicinal and aromatic plants in Mexico have been studied and explored through history. Day by day there is an increase in ethnobotanical, taxonomic, or phytochemical studies, providing an encouraging picture of research in Mexico and to support its use in traditional medicine. Chemical and biological exploration permit to provide solutions to the treatment of diseases. With this background, the objective of this chapter is to show the potential of endemic medicinal and aromatic plants in Mexico.",signatures:"Mariana Palma-Tenango, Ruben San Miguel-Chávez and Ramón\nMarcos Soto-Hernández",downloadPdfUrl:"/chapter/pdf-download/53285",previewPdfUrl:"/chapter/pdf-preview/53285",authors:[{id:"65790",title:"Prof.",name:"Marcos",surname:"Soto-Hernández",slug:"marcos-soto-hernandez",fullName:"Marcos Soto-Hernández"},{id:"193077",title:"Dr.",name:"Mariana",surname:"Palma-Tenango",slug:"mariana-palma-tenango",fullName:"Mariana Palma-Tenango"},{id:"198076",title:"MSc.",name:"Rubén",surname:"SanMiguel- Chavez",slug:"ruben-sanmiguel-chavez",fullName:"Rubén SanMiguel- Chavez"}],corrections:null},{id:"53274",title:"Romanian Aromatic and Medicinal Plants: From Tradition to Science",doi:"10.5772/66513",slug:"romanian-aromatic-and-medicinal-plants-from-tradition-to-science",totalDownloads:2554,totalCrossrefCites:3,totalDimensionsCites:4,hasAltmetrics:1,abstract:"From ancient times, plants have been used by humans for food, fodder, fibre and medicinal purposes. Several plants were empirically considered as treatments for a large array of illness and medical conditions. Each community had specific natural remedies, based on the geographical area, environmental conditions and other factors. Thus, the use of plants can be considered as part of the intangible cultural heritage of each community. In the geographical area of today’s Romania, the ancient inhabitants, Dacians, had very good knowledge regarding the use of plants for medicinal purposes, as presented by several historical sources. The present work describes protocols for the extraction and purification of natural extracts, analytical characterisation, in vitro and in vivo evaluation of their potential applications as well as some practical examples of their application on selected Romanian native medicinal and aromatic plants. The presented results offer scientific support to their traditional use, suggesting in the same time some modern applications, for example in the nanotechnology field.",signatures:"Radu Claudiu Fierascu, Irina Fierascu, Alina Ortan, Sorin Marius\nAvramescu, Cristina Elena Dinu-Pirvu and Daniela Ionescu",downloadPdfUrl:"/chapter/pdf-download/53274",previewPdfUrl:"/chapter/pdf-preview/53274",authors:[{id:"137269",title:"Dr.",name:"Radu Claudiu",surname:"Fierascu",slug:"radu-claudiu-fierascu",fullName:"Radu Claudiu Fierascu"},{id:"176480",title:"Dr.",name:"Irina",surname:"Fierascu",slug:"irina-fierascu",fullName:"Irina Fierascu"},{id:"193808",title:"Dr.",name:"Alina",surname:"Ortan",slug:"alina-ortan",fullName:"Alina Ortan"},{id:"193809",title:"Dr.",name:"Sorin Marius",surname:"Avramescu",slug:"sorin-marius-avramescu",fullName:"Sorin Marius Avramescu"},{id:"193810",title:"Prof.",name:"Cristina",surname:"Dinu-Pirvu",slug:"cristina-dinu-pirvu",fullName:"Cristina Dinu-Pirvu"},{id:"193811",title:"Dr.",name:"Daniela",surname:"Ionescu",slug:"daniela-ionescu",fullName:"Daniela Ionescu"}],corrections:null},{id:"53507",title:"Phytochemistry, Antioxidant, Antibacterial Activity, and Medicinal Uses of Aromatic (Medicinal Plant Rosmarinus officinalis)",doi:"10.5772/66605",slug:"phytochemistry-antioxidant-antibacterial-activity-and-medicinal-uses-of-aromatic-medicinal-plant-ros",totalDownloads:2196,totalCrossrefCites:2,totalDimensionsCites:5,hasAltmetrics:0,abstract:"Rosemary is a well-known aromatic and medicinal plant whose consumption serves to remedy the number of disorders. Its essential oil (EO) constitutes an important ingredient for well-being feeling improvement through beauty products such as soaps, perfumes, and deodorants. The identification of phytochemical compounds is based on the peak area, retention time molecular weight, molecular formula, chemical structure, and pharmacological actions. It contains chemical constitutions, which may be useful for various herbal formulations as anti-inflammatory, analgesic, antipyretic, cardiac tonic, and antiasthmatic. Therefore, this chapter reviews the phytochemical compounds of Rosmarinus officinalis, using methanolic extraction. The phytochemical compound is screened by gas chromatography-mass spectrometry (GC-MS) method and the evaluation of antimicrobial and antioxidant activities of the essential oils.",signatures:"Imad Hadi Hameed and Ghaidaa Jihadi Mohammed",downloadPdfUrl:"/chapter/pdf-download/53507",previewPdfUrl:"/chapter/pdf-preview/53507",authors:[{id:"193792",title:"Prof.",name:"Imad Hadi",surname:"Hameed",slug:"imad-hadi-hameed",fullName:"Imad Hadi Hameed"},{id:"198325",title:"Prof.",name:"Ghaidaa",surname:"Jihadi",slug:"ghaidaa-jihadi",fullName:"Ghaidaa Jihadi"},{id:"198326",title:"Prof.",name:"Mohanad",surname:"Jawad",slug:"mohanad-jawad",fullName:"Mohanad Jawad"},{id:"203230",title:"Prof.",name:"Amean",surname:"A Yasir",slug:"amean-a-yasir",fullName:"Amean A Yasir"}],corrections:null},{id:"53488",title:"Some Mexican Plants Used in Traditional Medicine",doi:"10.5772/66637",slug:"some-mexican-plants-used-in-traditional-medicine",totalDownloads:1984,totalCrossrefCites:6,totalDimensionsCites:6,hasAltmetrics:0,abstract:"In Mexico, there is an area known as semiarid region that is located in northern Mexico, and this region is rich in biodiversity (endemic flora and fauna). In the semiarid region of Mexico are more than 3500 species of plants that have been identified and used as natural alternatives to treat different ailments (digestive ailments, kidney problems, skin conditions, etc.). The use of plants for medicinal purposes was a common practice in Mexico before the arrival of the Spanish in the sixteenth century; although this knowledge was underestimated for a long time, now interest has reemerged in the use of plants as alternative remedies or traditional medicine. It is now known that the medicinal plant capacity is due to its biological properties, which are due to chemical compounds that are synthesized by the plant metabolisms, called phytochemicals. Phytochemicals are bioactive compounds that have important biological properties such as anticancer property, antimicrobial, antiparasitic, antioxidant, and interest in the recovery of these compounds has grown in recent years, in order to find natural alternatives to synthetic drugs, which they are used for different chronic conditions such as cancer.",signatures:"Mayela Govea-Salas, Jésus Morlett-Chávez, Raúl Rodriguez-Herrera\nand Juan Ascacio-Valdés",downloadPdfUrl:"/chapter/pdf-download/53488",previewPdfUrl:"/chapter/pdf-preview/53488",authors:[{id:"183439",title:"Dr.",name:"Raul",surname:"Rodriguez-Herrera",slug:"raul-rodriguez-herrera",fullName:"Raul Rodriguez-Herrera"},{id:"193767",title:"Dr.",name:"Jesus",surname:"Morlett",slug:"jesus-morlett",fullName:"Jesus Morlett"},{id:"197591",title:"MSc.",name:"Mayela",surname:"Govea-Salas",slug:"mayela-govea-salas",fullName:"Mayela Govea-Salas"},{id:"197592",title:"Dr.",name:"Alberto",surname:"Ascacio-Valdes",slug:"alberto-ascacio-valdes",fullName:"Alberto Ascacio-Valdes"}],corrections:null},{id:"53475",title:"Education for Sustainable Development",doi:"10.5772/66738",slug:"education-for-sustainable-development",totalDownloads:1819,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"This chapter focuses on Education for Sustainable Development (ESD) for communities selling medicinal plants in northern KwaZulu-Natal, South Africa. The purpose is to equip the participating medicinal plant sellers with knowledge and skills related to the trade of medicinal plants. In particular, the study focuses on cultivating the participants’ awareness of the importance of conducting their business based on principles of conservation, sustainable livelihoods and environmental sustainability. The study followed a case study design within a mixed methods research paradigm. Data collection involved the use of face-to-face questionnaire administration and follow-up focused group interviews. Phase 1 results revealed a number of challenges faced by the medicinal plant sellers. These included processing, storage and packaging, lack of business skills and the conservation of medicinal plants and their products. Following a capacity building intervention based on ESD and non-formal education principles, phase II results showed that the medicinal plant sellers had revised some of their business practices–such as pricing techniques and record keeping. However, processing of medicinal plant materials, storage, packaging and conservation remained a challenge that needed further attention. In particular, sustainable harvesting practices and cultivation of medicinal plants in home gardens still presented some difficulties.",signatures:"Busisiwe Ndawonde, Sitwala Namwinji Imenda and Humbulani\nNancy Mutshaeni",downloadPdfUrl:"/chapter/pdf-download/53475",previewPdfUrl:"/chapter/pdf-preview/53475",authors:[{id:"193656",title:"Dr.",name:"Busisiwe",surname:"Ndawonde",slug:"busisiwe-ndawonde",fullName:"Busisiwe Ndawonde"}],corrections:null},{id:"54021",title:"Medicinal Plants in the Northwestern China and Their Medicinal Uses",doi:"10.5772/66739",slug:"medicinal-plants-in-the-northwestern-china-and-their-medicinal-uses",totalDownloads:2518,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"The Northwestern China is a typical arid and semi-arid region of inner Asia, where some important medicinal species such as Angelica sinensis, Radix astragali, Radix codonopsis, Radix et rhizoma rhei, Radix glycyrrhizae, Lycium barbarum L are found and grew in the mountains areas, or desert areas. Among them, A. sinensis, R. astragali and R. glycyrrhizae are frequently used in traditional Chinese medicines and herbal prescriptions, thus encouraged many researchers to investigate and develop them. Our purpose is to provide a review of recent advances about three typical medicinal plants of A. sinensis, Astragalus membranaceus and R. glycyrrhizae in Northwestern China, mainly referring to botanical identity, chemical constituents, pharmacological studies, application in formulation, safety and cultivation practices. That will provide some valuable information for the further study and development of medicinal plants in Northwestern China.",signatures:"Liu Dongling, Wang Yinquan and Tian Ling",downloadPdfUrl:"/chapter/pdf-download/54021",previewPdfUrl:"/chapter/pdf-preview/54021",authors:[{id:"193765",title:"Dr.",name:"Yin Quan",surname:"Wang",slug:"yin-quan-wang",fullName:"Yin Quan Wang"}],corrections:null},{id:"53229",title:"Aromatic Compounds: From Plant to Nutraceuticals—An Example of Capsaicin",doi:"10.5772/66606",slug:"aromatic-compounds-from-plant-to-nutraceuticals-an-example-of-capsaicin",totalDownloads:1521,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The current study is on extraction of capsaicin from capsicum using chromatography. Nuclear magnetic resonance was used to ascertain carbon structures of the extract, with the yield confirmed by nuclear magnetic resonance to be 98% pure capsaicin. The chemistry, pharmacological action, and side effects of capsaicin are thereafter discussed.",signatures:"Adebayo Taiwo Ezekiel Jolayemi",downloadPdfUrl:"/chapter/pdf-download/53229",previewPdfUrl:"/chapter/pdf-preview/53229",authors:[{id:"193523",title:"Dr.",name:"Adebayo",surname:"Jolayemi",slug:"adebayo-jolayemi",fullName:"Adebayo Jolayemi"}],corrections:null},{id:"52870",title:"Capsaicin: Aromatic Basis and Mechanism of Action: An Example of Positive Inhibition",doi:"10.5772/66103",slug:"capsaicin-aromatic-basis-and-mechanism-of-action-an-example-of-positive-inhibition",totalDownloads:1834,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:1,abstract:"This work will, in addition to describing the aromatic basis of capsaicin, elucidate its mechanism of action through a positive inhibition of the nerve conduction, which ultimately accounts for the various pharmacological effects of capsaicin on pain control, cardiovascular mechanisms, as well as its effects on genitourinary and gastrointestinal tracts.",signatures:"Adebayo Taiwo Ezekiel Jolayemi",downloadPdfUrl:"/chapter/pdf-download/52870",previewPdfUrl:"/chapter/pdf-preview/52870",authors:[{id:"193523",title:"Dr.",name:"Adebayo",surname:"Jolayemi",slug:"adebayo-jolayemi",fullName:"Adebayo Jolayemi"}],corrections:null},{id:"53283",title:"Lesser Known Aromatic Plants in Nigeria",doi:"10.5772/66484",slug:"lesser-known-aromatic-plants-in-nigeria",totalDownloads:2040,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Herbs and spices are used in all cultures as natural foodstuffs and for medicinal purposes. Siphonochilus aethiopicus, Monodora myristica and Crateva adansonii are some of the spices which are not commonly used. They improve the taste of food, and through their anti-oxidant, anti-microbial and anti-fungal properties, they could act as food preservatives. There is an accumulation of evidence for the usage of these spices medicinally as anti-inflammatory, anti-plasmodial, anti-sickling, anti-oxidant and chemopreventive agents. There have also been investigations to identify the active constituents of these spices and to verify their pharmacological actions. This article aims at reviewing the available data on these investigations and the basis for usage in several diseases and conditions.",signatures:"Ngozichukwuka P. Igoli and John O. Igoli",downloadPdfUrl:"/chapter/pdf-download/53283",previewPdfUrl:"/chapter/pdf-preview/53283",authors:[{id:"194059",title:"Dr.",name:"Ngozichukwuka",surname:"Igoli",slug:"ngozichukwuka-igoli",fullName:"Ngozichukwuka Igoli"},{id:"196076",title:"Prof.",name:"John",surname:"Igoli",slug:"john-igoli",fullName:"John Igoli"}],corrections:null},{id:"53301",title:"From Medicinal Plant Raw Material to Herbal Remedies",doi:"10.5772/66618",slug:"from-medicinal-plant-raw-material-to-herbal-remedies",totalDownloads:4834,totalCrossrefCites:8,totalDimensionsCites:15,hasAltmetrics:0,abstract:"The use of medicinal plants is old as the existence of mankind. According to World Health Organization (WHO) data, about 80% of world population are using products based on medicinal herbs. Phytotherapy is based on the use of herbal drugs and medicinal products for the purpose of prevention and treatment. Rational phytotherapy is a modern concept of herbal medicines using, which are made of standardized herbal extracts. The quality of each final product is guaranteed by the use of raw materials of a standard quality, defined process of production, and validated equipment. Quality control of herbal drugs and herbal isolates (tinctures, extracts, and essential oils) is done according to the requirements of Pharmacopoeia and other relevant regulations. The scope of phytopreparation quality control depends on its pharmaceutical form. The formulation of a new phytopreparation is a process that has strictly defined phases: from analysis of literature and market, through defining recipes, validation of the production process, quality control of a final product to the preparation of technological and registration documents. The aim of this chapter is to present the process of herbal preparations production from selecting plant raw materials to herbal remedies (on the examples of making tea, tea mixture, drops, gels, and capsules).",signatures:"Sofija M. Djordjevic",downloadPdfUrl:"/chapter/pdf-download/53301",previewPdfUrl:"/chapter/pdf-preview/53301",authors:[{id:"84281",title:"Dr.",name:"Sofija",surname:"Djordjevic",slug:"sofija-djordjevic",fullName:"Sofija Djordjevic"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"10356",title:"Natural Medicinal Plants",subtitle:null,isOpenForSubmission:!1,hash:"943e56ccaaf19ff696d25aa638ae37d6",slug:"natural-medicinal-plants",bookSignature:"Hany A. 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This book is an illustration of the use of mathematics to solve specific problems in engineering, statistics, and science in general.",isbn:"978-1-83880-827-3",printIsbn:"978-1-83880-825-9",pdfIsbn:"978-1-83880-828-0",doi:"10.5772/intechopen.87892",price:119,priceEur:129,priceUsd:155,slug:"forecasting-in-mathematics-recent-advances-new-perspectives-and-applications",numberOfPages:154,isOpenForSubmission:!1,isSalesforceBook:!1,isNomenclature:!1,hash:"9a3ad05fef0502040d2a238ad22487c0",bookSignature:"Abdo Abou Jaoude",publishedDate:"January 27th 2021",coverURL:"https://cdn.intechopen.com/books/images_new/10062.jpg",keywords:null,numberOfDownloads:4889,numberOfWosCitations:1,numberOfCrossrefCitations:4,numberOfDimensionsCitations:6,numberOfTotalCitations:11,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"May 7th 2020",dateEndSecondStepPublish:"May 28th 2020",dateEndThirdStepPublish:"July 27th 2020",dateEndFourthStepPublish:"October 15th 2020",dateEndFifthStepPublish:"December 14th 2020",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"2 years",secondStepPassed:!0,areRegistrationsClosed:!0,currentStepOfPublishingProcess:5,editedByType:"Edited by",kuFlag:!1,biosketch:"Holder of two PhDs in Mathematics and Prognostics from the Lebanese University and Aix-Marseille University, developer of a novel branch of pure and applied mathematics known as 'the complex probability paradigm' which joins probability theory with complex variables and analysis.",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"248271",title:"Dr.",name:"Abdo",middleName:null,surname:"Abou Jaoudé",slug:"abdo-abou-jaoude",fullName:"Abdo Abou Jaoudé",profilePictureURL:"https://mts.intechopen.com/storage/users/248271/images/system/248271.jpg",biography:"Abdo Abou Jaoudé has been teaching for many years and has a passion for researching and teaching mathematics. He is currently an Associate Professor of Mathematics and Statistics at Notre Dame University-Louaizé (NDU), Lebanon. He holds a BSc and an MSc in Computer Science from NDU, and three PhDs in Applied Mathematics, Computer Science, and Applied Statistics and Probability, all from Bircham International University through a distance learning program. He also holds two PhDs in Mathematics and Prognostics from the Lebanese University, Lebanon, and Aix-Marseille University, France. Dr. Abou Jaoudé's broad research interests are in the field of applied mathematics. 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1. Introduction
\n
The need for high-performance heat-dissipating devices is highly needed in today’s rapidly changing power device and electronics markets [1, 2]. With worldwide movements on the implementation of Industry 4.0, we will see more radical changes in the way tangible products are manufactured [3]. At the same time, rapid product design cycles are becoming more of a standard rather than a demand. Thus, the need for automated design processes carried out with the use of computer as tools has never been so imperative. Computational design procedures have been more widely accepted during the past decades due to the improvements in computing technologies [4]. Together with this, rapid advancements in the algorithms and automated design procedures have flourished. Topology optimization can be viewed as one of the most promising automated design procedures, which has been an active topic of research for almost three decades.
\n
Topology optimization is an automated, ‘best material layout’ process, which follows the governing equations of one or more physics taken into consideration under a user-defined set of conditions and limitations. Several methods and techniques are already well developed especially for the field of structural engineering. Topology optimization is slowly being used in mainstream design processes of tangible products due to the advancements in computational power of computers, the optimization methods, and techniques used in topology optimization itself.
\n
Computational tools have been developed to aid and answer some of the engineering queries, but the main design of the structure is usually left to experienced and specialized professionals. Commonly applied modern-day topology optimization methods utilize finite element analyses (FEA) where each discretization is treated as a design variable. By choosing and varying the adequate material property related to the investigated case, we would iteratively investigate which element is helpful, thus material is ‘allocated’, and which ones are not, thus can be left as ‘void’, from the design space. We can also set areas that must be filled with material or areas where materials should not be placed. There are a number of learning materials for topology optimization, most are from one research group from Denmark. Among their developments are a free mobile app, TopOpt [5] and TopOpt3D [6], which can execute structural topology optimization and output. STL files ready for three-dimensional (3D) printing. The interface, some common definitions for structural topology optimization and an example are presented in Figure 1.
Figure 1.
TopOpt app [5] developed by DTU reflecting the essential elements of topology optimization.
\n
The earliest work related to topology optimization can be traced back to the ingenious Australian inventor who formulated Michell’s truss theory [7] (named after inventor George Michell). The said theory dealt with the least-volume topology of trusses with a single load condition and a stress constraint. Not only was this imaginatively ingenious, it was also ahead of his time where almost nothing was known about the techniques of structural optimization. His works were ignored for almost half a decade where it was rediscovered by Cox [8, 9] and Owen [10] in the 1960s, the same time when computers were acknowledged as automation tools. It was Hemp [11] and his co-workers who had spent most of their professional lives and comprehensively studied Michell structures. Modern-day computer-aided topology optimization can probably be traced back to the works of Bendsoe and Kikuchi [12] on homogenization who had also coined and popularized the term topology optimization. For the following decades, their works had sparked the interest of many researchers and might not have necessarily had any product-related applications. In the next section, we first briefly discuss the main methods commonly used in topology optimization.
\n
2. Topology optimization methods and learning codes
\n
Different methods have been developed in finding solutions to the optimal layout problem. Since Bendsoe and Kikuchi’s work in 1988 [12], focus has been more on finite element (FE)-based topology optimization of continuum structures. Different methods have been developed since. The differences in the different methodologies lay in the way the design space, and consequently, the design variable is parameterized and controlled. Some methods directly define the design variables on the finite element domain, while others define a separate function from which the generated structure is interpreted. In both cases, ‘0-1’ designs or ‘void/solid’ designs are desired because they can be easily interpreted and physically realized. Here, 1 or solid means that material is allocated on the design element and 0 or void means that material is not present in the design element. In some methods, ‘grey’ or intermediate densities, which are values between 0 and 1, are encountered and observed. The following subsections outline some of the popular methods for topology optimization. We also list references at the end of each method where codes (usually written in MATLAB) are readily available for interested readers. These codes also contain more information on the mathematical background and rationale for each method. These codes, however, are usually written in the context of structural topology optimization but could be modified appropriately to solve heat-transfer problems. The detailed modifications needed are explicitly given in Appendix B of Ref. [13].
\n
2.1. Homogenization method
\n
Pioneering work by Bendsøe and Kikuchi [12] posed a structural layout problem within the context of homogenization theory. In their method, now known as the homogenization method, they treat each element as porous material whose microstructures can be modelled and controlled. By tuning these microstructures, macro-scale material properties are realized which are best suited for the stress experienced from each element. The periodic microstructures are defined for each discretized unit cell in the finite element domain. In their work, they had demonstrated two potential microstructures that could be generated on each unit cell. The first one being a perforated microstructure in the form of a square cell with a rectangular void with three control parameters (μ1, μ2 and θ). The second was a layered microstructure with two isotropic constituents with the same control parameters. These two types of microstructure definition are visualized in Figure 2 (a). Under the assumption of infinitesimally small periodic unit cells and the adequate microstructure definition, it was deemed that any anisotropic macro-scale representation of the material can be achieved such as pure solid, pure void, composite and porous material.
Figure 2.
(a) Schematic of the treatment of design variables contained in elements showing two possible microstructures. (b) Result for a truss problem reflecting generated microstructures [14].
\n
A single set of variables corresponding to each microstructure can be used for each design element or can be extended to a sub-mesh to generate finer structures. Topology optimization, in this sense, becomes a problem to determine the optimal combination of these design variables, which corresponds to the optimal macro-scale distribution of properties which minimize a given objective function. This approach was investigated in the 1990s but has received less attention in the recent years due to the emergence of more efficient methods. Nevertheless, it gave the fundamental concepts and ideas in the other methods. Additionally, some methods that will be later mentioned apply alternative formulations to alleviate the common numerical issues found in explicit topology parameterization. Nowadays, it has found its application in finding ways of how to realize high-performing microstructures and is called ‘inverse homogenization’.
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2.2. ‘Hard-kill’ methods
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‘Hard-kill’ methods are a generalization of methods that explicitly treat each element as material or void. Unlike other methods, they do not relax the ‘0-1’ problem on topology optimization. These methods gradually remove (in some cases add) elements that represent absence (or presence) of a material into the design domain explicitly for each iteration step. A few of these methods utilize combinatorial techniques such as genetic algorithms and simulated annealing, to name a few. Another ‘hard-kill’ method that is based on sensitivity information is known as the concept of using topological derivatives (or topological sensitivity) [15]. The concept of topological derivatives is that undesired computational nodes are explicitly removed. The most well-known ‘hard-kill’ method in topology optimization is the evolutionary structural optimization (ESO) [16] and, more recently, the bi-directional evolutionary structural optimization (BESO) [17]. BESO is differentiated from ESO in a way that ESO only allows for the removal of elements while BESO allows for both the addition and removal of elements that represent the presence or absence of a material based on an ‘optimization criterion’, which is evaluated in each small domain or element. This is analogous to slowly evolving the shape of a structure towards the desired optimum result by removing (or adding) the elements that do not contribute to the improvement of the desired objective function. The choice of material to be removed (or added) is based on heuristic criteria, which is based on sensitivity information of the iteration steps. As a result of these heuristic features, the technicality of this method is often questioned for a robust theoretical basis does not exist [18, 19]. One of the most attractive features of these hard-kill methods is its simplicity with which they can be utilized with commercial finite element packages. It is claimed that the integration of algorithms based on hard-kill methods with finite element analysis (FEA) solvers requires only minor modification in the pre- or post-processing steps [19]. Also, structures generated are free from intermediate or ‘grey’ material representations due to the nature of its solution method of explicitly removing (or adding) material in the finite element system. More recently in [20], BESO has been relaxed to prevent the concerns given in [18, 19] and was termed ‘soft-kill’ method. An attempt to visually present the conceptual differences between the different ‘hard-kill’ methods is presented in Figure 3. In Figure 3 (a), elements are essentially removed from the FEA routine as executed in the original ESO. In Figure 3 (b), a void element is essentially allowed to ‘roam’ on neighbouring elements until such time it finds an optimal location and this is common for combinatorial techniques. In Figure 3 (c), a node is essentially removed and creates an area of void elements, and this is the concept behind the topological derivatives. A MATLAB code of the relaxed BESO implementation is also given in Ref. [20].
Figure 3.
Conceptual differences of different ‘hard-kill’ methods (a) ESO, (b) combinatorial techniques and (c) topological derivative.
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2.3. Boundary variation methods
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Boundary variation methods are among the most recent and noteworthy contributions that lead to advancements in structural topology optimization. Boundary variation methods have originated in shape optimization techniques and had been recently introduced to structural topology optimization. They are differentiated from the other methods from the fact that structure domain and boundaries are represented based on implicit functions rather than an explicit parameterization of the design domain. In most methods, the design variable in the domain is given explicitly as values from 0 to 1 where 0 would represent the absence of material and 1 represents the presence of material. For boundary variation methods, the structural boundaries are implicitly defined as the contour line of a field which is a function of the design variable. Boundary variation methods are currently dominated by two methods: the level-set method and the phase-field methods. Both of these methods produce results in the design domain with crisp and smooth edges that require little post-processing effort to realize the relevant structural features. Additionally, these methods are fundamentally different from shape optimization techniques because they allow both the movement of the structural boundary and topological changes (e.g. formation, disappearance and merging of void regions).
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2.3.1. Level-set method
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Level sets for moving interface problems in physics were first developed by Osher and Sethian [21], with the fundamental goal of tracking the motion of curves and surfaces. This method has been applied in a wide variety of research areas [22, 23] including topology optimization. The level-set method was first applied to topology optimization in the early 2000s by Sethian and Wiegmann [24], where it was used to represent the free boundary of a structure for linearly elastic problems in structural design. In another direction, Osher and Santosa [25], in about the same time, combined level sets with a shape sensitivity analysis framework for the optimization of structural frequencies.
\n
In the level-set method, the boundaries of the structure are represented on the zero-level curve (or contour) of the scalar function Φ which is consequently called the level-set function. Topological functions such as the changes in the boundary, merging of boundaries and formation of new voids are performed on the level-set function. The geometric boundary shape is modified by controlling the motion of the level set according to the physical problem and optimization conditions [26]. It is worth noting that most level-set formulations still rely on finite elements despite the smooth boundary representation. Thus, boundaries are still represented by discretized mesh which leads to some unsmooth results. Alternative techniques such as the extended finite elements (XFEMs) [27] have been utilized to represent the geometry in the analysis of the model which produces superior, smooth and continuous boundaries.
\n
The level-set method does not exhibit intermediate material densities since the presence or absence of material on the domain is determined at the zero-level-set function. However, current level-set methods are known for their dependency on the initial design and locations of the level-set functions. This drawback poses a severe problem in the acceptability of solutions of level-set functions but new developments have been made to address and improve this deficiency [28]. Also, at some cases the level-set method might require re-initialization during the process when the level-set function becomes too flat or too steep. This adds computational complexity and additional tuning parameters to the algorithms which is undesirable especially for implementation with commercially available software. A visualization of this concept is presented in Figure 4 (a). A MATLAB code for the level-set method is available in Ref. [29].
Figure 4.
Conceptual difference between (a) level-set method and (b) phase-field method.
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2.3.2. Phase-field method
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The phase-field method originates from theories developed to track and represent phase transition and phase interface phenomena in surface dynamics [30]. This method has been utilized for solid-liquid transitions, diffusion, solidification, crack propagation, multiphase flow and eventually in topology optimization [31]. In the application of these theories, a phase-field function is specified over the design domain that is composed of two phases (e.g. A and B), which are represented by two variables as a function of the phase-field function. The boundary region between phases is a continuously varying region of thin finite thickness.
\n
In topology optimization utilizing the phase-field method [31–33], this interface region defines the structural boundary, thus separating material from void, and is modified via a dynamic evolution of the phase-field function. The primary difference between the level-set and phase-field methods is mainly due to the fact that in the phase-field method, the interface between the boundaries of the two distinct phases is not tracked throughout optimization. Whereas in the level-set method, the boundary is tracked as it moves during the optimization process. In other words, the governing equations of phase transition are solved over the complete design domain without the initial information of the phase interface location. Consequently, phase-field methods do not require the re-initialization step as do level-set functions. Its conceptual difference with the level-set method is presented in Figure 4 (b). A MATLAB code for the phase-field method is available for download by visiting the website of Ref. [31].
\n
2.4. Density-based methods
\n
Currently, the most widely used methods for structural topology optimization are explicit parameterizations that are broadly classified as density-based methods. Variations of this method are termed ‘material interpolation’, ‘artificial material’, ‘power law’ and ‘solid isotropic material with penalization (SIMP)’ methods. Although SIMP is only one of the methods, its popularity has led for the term to be colloquially used in place of density-based methods. Density-based methods are an extension of the works on the homogenization method. This type of method has experienced much popularity in recent years in this community due to its conceptual simplicity and ease in implementation. Nearly all commercial topology optimization tools utilize a density-based method [34].
\n
Similarly with the homogenization method, these density-based methods operate on fixed domain of finite elements. The main difference is that, rather than a set of microstructure properties, each finite element contains only a single design variable. This variable is often understood as the element material density, ρe. The relevant material property of each element concerned with the physics involved, for example, the elastic modulus for structural problems or thermal conductivity for heat-transfer problems, is made as a function of the density design variable. This is usually accomplished by utilizing an interpolation function. The topology generated in Figure 1 was based on this method. Tremendous amount of literature is available for this method and the book [13] contains much discussion on this method as well as an ’99-line code’ for MATLAB which pioneered the publication of codes for educational purposes in topology optimization. It has been reworked by Andreassen et al. in [35] which shortened the code as well as greatly improving its efficiency. Another rework was made by Liu et al. in [36] which provides the code’s extension to 3D problems in the MATLAB environment. More recently, Aage et al. [37] has released their code which utilized Portable, Extensible Toolkit for Scientific Computation (PETSc) and can handle problem scales which are not practical in MATLAB.
\n
3. The heat-transfer problem in the context of topology optimization
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The heat-transfer problem (as shown in Figure 5), in its weak form in the design domain, can be generalized as
where ρ is the material density, c is the specific heat of material, Tt is the temperature for a particular given time in transient cases, k is the thermal conductivity and qv is an internal heat generation rate per unit volume. In general, three types of boundary conditions may exist and can be considered: a temperature condition on Γ1, a heat flux conduction on Γ2, and a convective condition on Γ3. T0 is the initial temperature at time t = 0, Tb is a temperature imposed on Γ1, q is a heat flux boundary condition imposed on Γ2, h is the convective heat-transfer coefficient on Γ3 and T∞ is a fixed reference temperature, n is the boundary normal vector. Special treatment is needed for methods which produce intermediate densities for problems considering convective boundary conditions since boundaries are not well defined.
\n
Simplifying to a steady-state heat pure heat conduction case with only temperature boundary conditions and heat flux boundary conditions considered, Eq. (1) is reduced to
\n
qv=kΔTin ΩT=Tbon Γ1−k∂T∂n=qon Γ2E2
This form is often considered for the ‘volume-to-point’ problem commonly investigated in heat conduction problems. Using the virtual temperature field, v, the weak formulation of the heat conduction problem is given by
\n
∫Ω(kΔT−qv)νdx=0E3
After integration by parts has been carried out and applying the heat flux boundary condition, Eq. (3) becomes
\n
∫Ωk∇T⋅∇ν−qvνdx=∫Γ1k∇T⋅nνdΓ=−∫Γ2qvdΓE4
And the weak form can be written as
\n
a(T,ν)=l(ν)∀ν∈T˜ T˜={T∈[H1(Ω)]|T=Tb on x∈Γ1}E5
where v is in T˜ and T˜ is a subset of a Sobolev space. The left-hand side a(T, v) represents the energy bilinear form. It is obtained from Eq. (4) and is given as
\n
a(T,ν)=∫Ωk∇T⋅∇νE6
The l(ν) term is called the thermal load linear form and can similarly be obtained from Eq. (4) and is given as
\n
l(ν)=∫Ωqvνdx−∫Γ2qvdΓE7
This is often used for deriving the propagating velocity of the material boundaries by the material derivative theory in boundary variation methods and the homogenization method. One design objective or thermal compliance measure, c, that is considered as the mean temperature could be expressed as
\n
c(Ω)=∫Ωk∇T⋅∇TdxE8
And finally the topology optimization problem of the heat conduction problem is expressed as
\n
minΩ⊆Dc(Ω)s.t.a(T,ν)=l(ν),for all ν∈T˜∫Ddx≤VmaxE9
where D contains the material distributed in the design domain Ω and Vmax is a volumetric constraint. In the context of density-based topology optimization, we introduce the element density, ρe, and applying a discretized optimization model, for example, FEA, the heat conduction problem is defined as
\n
minρec(ρe)=TTKT=QTTs.t.KT=QVf=V(ρe)/Vo0<ρe≤1E10
where K is the global thermal conductivity matrix, T is the node temperature vector and Q is the applied thermal load. It is to be noted that the global thermal conductivity matrix if formed from the assembly of individual element thermal conductivity matrix, ke, and the material interpolation schemes is applied here as is formally given as
\n
K(ρe)=∑e=1Nkeff(ρe)keE11
where keff is the material interpolation scheme. The objective function could then be expressed as
\n
c(ρe)=QTT,where Tsolves: ∑e=1Nkeff(ρe)keT=QE12
One simple form of the interpolation scheme was presented when SIMP was introduced and is given as
\n
keff(ρe)=(kmax−kmin)ρepE13
Gradients are usually required by the optimization algorithms needed for the update process in topology optimization. These are easily derived for the objective and constraints involving only ρe. For functions that depend also on temperatures, derivative can be obtained using the chain rule. These expressions will then contain derivatives of temperature, which in turn can be obtained by taking the derivative of the equilibrium equation, KT = Q. The most effective method for calculating the derivatives is to use the adjoint method, where derivatives of the temperature are not calculated explicitly. For the thermal compliance problem given above, we rewrite the objective function by adding a zero function:
\n
c(ρe)=QTT−λT(KT−Q)E14
where λ is called the Lagrangian multiplier which is an arbitrary, but fixed real vector. We then obtain the derivative as
\n
∂c∂ρe=(QT−λTK)∂T∂ρe−λT∂K∂ρeTE15
which can be re-written as
\n
∂c∂ρe=−λT∂K∂ρeTE16
When λ satisfies the adjoint equation:
\n
QT−λTK=0E17
This equation is in the form of an equilibrium equation and for thermal compliance we see that we obtain directly that λ = T. Moreover, the form of the stiffness matrix means that the derivatives of the thermal compliance c(ρe) for the main problem in Eq. (10), considering the SIMP interpolation as presented in Eq. (13), are
\n
∂c∂ρe=−p(kmax−kmin)ρep−1TTKTE18
Thus, the derivative for the thermal compliance problem becomes easier to compute. It is also worth noting that the derivative is ‘localized’ to the element level; however, there is an effect from other design variables hidden in the temperature, T. The sensitivity is negative for all elements, so intuitively, additional material in any element decreases compliance, and makes the overall objective go lower. Using this sensitivity information, the material is redistributed and the process is repeated until a convergence criterion for the topology optimization process is attained. Each of the paper in the following chapter discusses the complete topology optimization process with more depth and varies depending on the method they have utilized.
\n
4. Chronology
\n
Interests in topology optimization can be represented by the recent amount of publications and citations over the years as presented in Figure 6(a) and (b) respectively. Although this figure might not accurately represent the exact number of papers, we can still see that the contribution of the papers related to ‘heat’ is roughly around 1/20th of the total contributions for topology optimization. It has also been increasing especially within the past decade. The amount of papers that are directly related to heat exchangers is arguably much less in number. The following subsections present a number of papers related to the interest of this chapter in its chronological order. For the completeness of the review, some papers at the end of each year are cited but no further elaborations are made due to access restrictions.
Figure 6.
Some scholarly metrics [38] for topology optimization: (a) publication count and (b) citation count. Highlighted in red are search results for ‘topology optimization’ + ’heat’. Note that results for this search are reflected on the red axis at the right-hand side and is scaled 1:10.
\n
4.1. Prior to 2005
\n
Rodrigues and Fernandez [39, 40] and Jog [41] utilized topology optimization for designing thermoelastic structures. Heat transfer was treated as one of the involved physics and as an extension to structural mechanics problems. It is worth noting that this was the beginning of the consideration for heat-transfer applications for topology optimization. However, in this chapter, we restrict ourselves to papers that focus more on heat conduction topology optimization (and a few convection cases) that is more directly related to cooling applications, such as the case for heat exchanger design.
\n
Bejan [42, 43] introduced constructal theory in the context of heat transfer. Although it is not directly categorized as topology optimization due to restrictions on size and orientation of each building block, it has provided interesting discussions and has formulated a fundamental problem for the heat-transfer community. The problem is now known as ‘volume-to-point (VP) problem’ or ‘access problem’ and discusses the need to layout a fixed amount of material in a heat-generating domain (such as a CPU).
\n
Xie et al. [44] used ESO explicitly for conduction problems. Several generalized claims were given regarding topology optimization, which might not necessarily be true on other methods. The paper is recognized as the first topology optimization paper presented directly solving pure conduction problems. In this paper, an element’s rejection is based on the integral of different thermal parameters, more specifically, integral of the temperature surrounding the element. They have highlighted the simplicity of the ESO method to generate novel structures and had considered anisotropic cases in one of the examples. He had also multiple loading cases and had presented two ways to introduce the loading cases, which generated distinct designs.
\n
Turteltaub [45] used SIMP for finding optimal material properties for transient heat conduction problems. Although the generated final designs were rich in intermediate densities due to the lack of penalization, this paper had first offered the possibility to extend topology optimization for transient problems. It was also mentioned that in the heat-transfer problems, special care should be given especially for convective boundary conditions. Though he did not use any explicit boundary-tracking scheme, it was already recognized that difficulty in convective boundaries are present.
\n
Haslinger et al. [46] applied the original homogenization method for conducting structures. Although the paper had focused more on convergence analysis and approximation strategies, it has utilized rank-two laminated structures to demonstrate the optimal heat conductor configurations for its test problems. The effective conductivity of the rank-one laminates was assumed to consist of harmonic and arithmetic means. Numerical minimization was performed by a subroutine from the Numerical Algorithms Group (NAG) Numerical Library which implemented a sequential quadratic programming (SQP) approach.
\n
Cheng et al. [47] introduced bionic optimization strategy for constructing better performing conductive paths. This was directly addressing and comparing results with Bejan’s original work. There is not much detail regarding their implementation but it can be viewed as a heuristic ‘hard-kill’ method. In the same year, Novotny et al. [15] introduced the concept of topological derivative. Although it is viewed as a ‘hard-kill’ method since it explicitly creates holes in the design domain, the concept is very far from ESO since it utilizes concepts from shape sensitivity analysis to evaluate the topological derivatives. Several theorems were presented in how it can be utilized for the design of conducting structures and has considered Robin boundary conditions in the formation of new holes. In a seemingly unrelated development, Borvall and Petersson [48] introduced the use of topology optimization for fluidic systems governed by Stokes flow. This field of topology optimization has its own unique developments and only a few papers which are relevant to the context of this chapter are mentioned. In this year, Bendsoe and Sigmund [49] also published their book on topology optimization which had some mention of heat-transfer topology as well as instructions for converting the learning code to conduction heat-transfer topology optimization. Guo et al. [50] presented the least dissipation principle.
\n
Xie [51] presented some changes in the ESO method for heat conduction applications which includes some revision for the criterion for rejection through some sensitivity measure. It is also mentionable that this paper had contained a good compilation of literature for shape sensitivity analysis in the field of heat transfer. It was not explicitly stated but the methods implemented were not as aggressive to the original ESO paper where degeneration was considered. This is more properly termed nowadays as ‘soft-kill’ ESO. Also, the design variable was constructed in terms of the element’s thermal conductivity. New interesting problems are given in the context of proper insulation design. Alberto and Sigmund [52] also published on multiphysics problems governed by Poisson’s equation, which includes conduction heat transfer. Ha et al. [53] presented non-linear heat conduction problems. Moon et al. [54] presented reliability-based topology optimization considering convection heat transfer.
\n
In this transitory stage, we can see that most of the existing methods are directly being migrated from structural topology optimization into the context of heat transfer. Here, we see ESO, homogenization method and SIMP which is more complex and harder to understand compared to papers in the next years. It is also worth noting that SIMP has already considered transient problems. The topological derivative is also introduced first in the context of heat-transfer problems which will later be a very powerful addition to level-set methods. It can also be said that in this year, fluid flow topology optimization has just started.
\n
4.2. 2005–2010
\n
Yoon and Kim [55] introduced an element connectivity parameterization (ECP) to alleviate problems in applying SIMP to multiphysics problems. A more specific problem of temperature undershooting was emphasized as a numerical instability when applying SIMP to include heat convection formulations on the generated structure boundaries (termed as ‘side convection’ in the paper). These undershootings in temperatures were deemed to be impossible and infeasible solutions which needed to be strongly addressed. Thus, their paper had given special attention to heat transfer utilizing the zero-length heat conductors as element connectivity measures in ECP. Good results were obtained using the method which was again extended to heat-dissipating structures and electro-thermal actuators. In the same year, Ha and Cho [56] introduced the level-set approach explicitly for heat conduction problems. Their paper contains a detailed yet understandable introduction for level-set methods in the context of heat-conducting structures. It is also worth noting that due to the nature of the level-set method of clear and well-defined boundaries, convection heat transfer was already considered. However, it was not directly applied to the evolving boundaries. Also, it was well reported in this pioneering paper for level-set method for heat-transfer topology optimization that the generated structures were highly dependent on the initial distribution of holes in the design domain since this implementation cannot create new holes during the optimization process. It was also mentioned that density-based method (SIMP) yielded better results for most cases, in terms of the number of iterations needed to achieve the converged results. Thermal compliance values for both methods were in very close agreements.
\n
Gersborg-Hansen et al. [57] introduced the use of the finite volume method (FVM) for heat conduction problems. It is worth noting that all previous papers were utilizing finite element methods and formulations. Their justification for utilizing FVM was made in the context of guaranteeing element-wise conservation of the physical quantities and to give access to FVM users to topology optimization. Element interface heat fluxes were calculated using the value of thermal conductivities based on the arithmetic and harmonic means of the surrounding nodes. The SIMP method was utilized for their implementations. Two unique compliance measures were investigated. It was mentioned that the results from FEM and FVM were qualitatively similar and the designs suffered high-mesh dependence when the compliance measure for arithmetic average was used even though the penalty value, p, in SIMP was increased up to 5 using the continuation approach. Using the harmonic average in the FVM formulation also reduces checkerboard formation up in their test cases. Donoso [58] revisited the VP problem in 3D space and used the optimality criteria (OC) method to find the solution.
\n
Zhuang et al. [59] utilized the concept of topological derivative in conjunction with the level-set method. The topological derivative was used to create new holes during the topology optimization process and thus eliminating the dependence on the initial hole distribution. A fixed cutting ratio was set for the topological derivative for generating new holes. Multiple load cases were also one of the highlights of their paper and highly consistent results and convergence curves were presented. Xu et al. [60], on the other hand, presented a combinatorial approach for optimizing the heat conduction paths. In their paper, they tried to solve the volume-to-point problem using simulated annealing and genetic algorithm (hard-kill approaches). Their paper had clearly presented their implementation scheme and had made comparisons with the results of bionic optimization. The optimal results were generalized as all high conductivity materials are continuous, no holes are present. For cases in which the thermal conductivity ratio is relatively small, shapes are thick and short surrounding the heat sink. When the thermal conductivity ratio is increased, the shape becomes more slender. Mathieu-Potvin and Gosselin [61] developed an evolutionary algorithm which tries to solve the VP problem. Their evolutionary algorithm aimed to minimize the hotspot temperature by displacing elements. Displacements were either by swapping of a heat-generating cell with a void cell and swapping a heat-generating cell with a conductive cell based on heat flux or by element-averaged heat flux and temperature. It is worth noting that in their implementation, an extended domain was utilized and during the evolution process, the cell elements can rearrange themselves in the extended domain. Due to the nature of the algorithm, exact repeatability of results is most unlikely but measures were adopted to find approximate performances and determine the algorithm’s robustness. Results were also compared to constructal theory in terms of the temperature objective function, kϕ, dimensionless distance measure, uniformity distribution measure and fractal dimension. Good discussions were made regarding each of these performance measures. Also in the same year, Bruns [62] clarified and resolved the problems presented by Yoon and Kim in their 2005 paper for convection-dominated heat-transfer problems in the context of density-based topology optimization. He has discussed the necessary techniques to prevent the ‘undershoot’ in temperatures mentioned by ensuring that the convection term contributions are treated as lumped matrix. Side convection terms are weighed by a density difference interpolation scheme and half of the total contribution is associated with two elements connected along the same edge. He has also used the SINH (pronounced as ‘cinch’) [63] method. He has concluded that poor convection modelling can greatly influence the design process. Kim et al. [64] reconsidered the printed circuit board (PCB) cooling problem but had included mechanical constraints. Zhuang et al. [65] minimized the quadratic mean temperature using the level-set method. Yoo and Kim [66] considered three-dimensional cooling fins using the ECP method.
\n
He and Liu [67] used the bi-directional evolutionary structural optimization (BESO). BESO is differentiated from ESO since BESO allows element addition which is not allowed in ESO. Using a uniform heat distribution problem, he compared the results with SIMP-based solutions. Special attention was given to the lack of intermediate elements in the ESO results, thus, easier manufacturability. Gao et al. [68] published another BESO paper and have considered both design-independent and -dependent loading. Design-dependent loading in this paper was defined as heat loads that vary whether or not material is present. In other words, without the presence of material heat cannot be generated. One case was presented to elaborate the difference and the effect of this assumption. Zhang and Liu [69] mentioned a new method for designing heat-conducting paths based on SIMP. This is related to a later publication mentioned in 2011. Yamasaki et al. [70] presented level-set method for both vibration and heat conduction problems.
\n
Iga et al. [71] introduced convection and heat generation design-dependent effects. He has used a different homogenization approach (termed as the homogenization design method in their paper) and defined a hat function in which the convection boundary conditions are easily applied. The hat function serves as the boundaries between the solid and the void regions. Interest in this paper is given for the utilization of a surrogate model for several fin models for including a better representation of the convection condition. They have also utilized sequential linear programming (SLP) for the update process during topology optimization. They have presented several examples which exhibit the adverse effects if an inappropriate convection modelling is used. Marczak and Anflor [72] introduced the boundary element method (BEM) as an alternative to FEA and FVM. In their paper, topological derivative was used as the means to generate the optimal topologies. BEM is differentiated from FEA and FVM since it does not directly compute based on cells or elements. BEM is considered as ‘mesh-free’ methods. Although nodes are still present inside the modelled domain, they are treated more as ‘recovery points’. Their examples and results were compared to the first ESO paper by Xie et al. in 1999. Dede [73] presented the use of COMSOL Multiphysics coupled with MATLAB for multiphysics topology optimization of heat and flow systems. Kim et al. [74] considered non-linear heat conduction and had designed structures based on the level set with topological derivatives. Pingen and Meyer [75] presented topology optimization for thermal transport.
\n
Yoon [76] considered a sequential computational procedure to design heat-dissipating structures that considers forced convective heat transfer. A staggered approach was used where the flow field was solved first. Artificial damping force was introduced to the Navier-Stokes equation, which was similar to techniques used in immersed boundary methods (IBMs). A total of four material properties were interpolated in his implementation. He had utilized density-based approach and SIMP interpolations for the material properties. Kim et al. [77] compared results for different sensitivity analyses formulations. They have reported the computational time for the finite difference method and two different design sensitivity analyses (DSA). It was reported that a large difference in terms of performance was present between the direct differentiation method and the adjoint variable method (a factor of about 142). The SIMP method was utilized but was not mentioned explicitly. A 3D example was also provided in one of their examples which considered a single convection boundary condition. Dede [78] performed investigations on topology-optimized designs for impinging jets. Single-jet geometry was investigated from coupled thermal-fluidic simulations in a commercial software package. SIMP-based topology optimization was then performed in MATLAB with MMA. The result from the single impinging jet was made as basis for a textured surface geometry for a 3D slot jet. It is worth noting that the two-dimensional (2D) model was made under the assumptions of laminar flow and the 3D multi-jet structure is expected to fall within the turbulent regime. Zhuang et al. [79] utilized level-set method for the design of multi-material heat-conducting structures.
\n
It can be said that the interest in heat-transfer topology optimization started in this time period. The papers presented in this time period were mostly dedicated and developed for heat transfer and design of heat exchangers. Investigations to include convection heat transfer as well as other design-dependent effects are also evident. Level-set method that is combined with the concept of topological derivative can be treated as state of the art during this time period. Also, ‘mesh-less’ topology optimization was introduced. SIMP has remained as a key method and its integration for FVM users has been mostly utilized.
\n
4.3. 2011–2015
\n
Yamada et al. [80] utilized the level-set method to include design-dependent effects such as convection boundary loading. A fictitious interface energy term was introduced for the design-dependent boundary conditions. Three-dimensional examples were given which clearly demonstrates clear and smooth optimal configurations. A regularization parameter was also utilized to tune the complexity of the optimal results. Convection loading was based on a fixed value. Zhang et al. [81] emphasized on the objective functional in topology optimization. It was highlighted that the cooling problem, as given by Bejan, needs to minimize the maximum temperature but most problems minimize the heat dissipation efficiency (termed as dissipation of heat potential capacity, DHTPC). A one-dimensional problem was revisited and a new objective of minimizing the geometric average temperature is presented in the context of a topology optimization problem. It was not explicitly mentioned what method was used and it is hypothesized that ESO was used due to the chosen problem and the well-defined boundaries of the optimal results (they have mentioned feasible direction method). Li et al. [82] had used the rational approximation of material property (RAMP) material interpolation scheme, OC based on density approach and a density filter was explored. Papoutsis-Kiachagias et al. [83] presented a constrained topology optimization for laminar and turbulent flows, including heat transfer.
\n
Marck et al. [84] performed multi-objective optimization (MOO) using the SIMP method. The MOO was carried out with the two separate goals of minimizing the average temperature and minimizing the variance in the temperature. A very detailed and elaborate description of the FVM-based topology optimization was given. Tests regarding the mesh dependence, sensitivity and density filters as well as the heat transfer in the domain of the VP problem were carried out. Interestingly, this paper had obtained results which had discontinuity in the structure. Dede [85] optimized and designed multi-pass-branching microchannels with topology optimization as a tool. Gregersen et al. [86] considered finite volume-based topology optimization of coupled fluid dynamic and thermal conduction systems. Lee [87] completed his dissertation for topology optimization of convective cooling systems.
\n
Koga et al. [88] demonstrated the complete product development cycle of a topology-optimized water-cooled heat exchanger. A fully coupled problem was solved using finite element method with some modifications to avoid numerical instabilities. A weighted logarithmic multi-objective function was used which contained a function to represent the power dissipation for the fluid flow and the heat dissipation for the heat-transfer problem. SINH was used in their implementation together with a weighed density filter. The heat exchanger was manufactured through electrical discharge machining and precision CNC milling. The experiments have matched well with the numerical simulations. It is worth noting that although the heat exchanger is a three-dimensional device, 2D modelling was employed for the topology optimization process. Burger et al. [89] explored the 3D solution for the volume to point (called volume to surface in this case) utilizing SIMP with method of moving asymptotes (MMAs) implementation. Full and partial Dirichlet boundary conditions were considered. In the partial Dirichlet boundary condition, only a square surface was given a fixed temperature. In the full Dirichlet boundary condition consideration, a volume of non-designable domain was set and the temperature conditions were set at the surfaces of a small volume before the allowable design domain. Different conductivity ratios varying volumetric constraints were explored as well as multiple boundary condition locations. Tree-like structures with four main branches extending to the corners of the design domain were the dominant optimal design features. Zhuang et al. [90] utilized triangular meshes on a transient heat conduction problem. Level-set method with topological derivative was used for the topology optimization process. Radial basis functions were used for defining the boundaries. A narrow band algorithm on the triangular mesh further improves the numerical efficiency. Dirker and Meyer [91] have performed performance tests for SIMP with MMA in an FVM setting. The VP problem was considered. It is worth noting that this work did not utilize any filtering techniques. A total of seven implementation cases were investigated. Six of the cases used predefined penalization parameters ranging from 1 to 5 in 0.5 intervals. Two volumetric constraints as well as three conductivity ratios were considered. Marck et al. [92] discussed topology optimization for heat and mass transfer problems in great detail for laminar flows. Jing et al. [93] has used BEM and level-set method for 2D heat conduction problems. Matsumori et al. [94] published fluid-thermal interaction problems under constant input power. Kontoleontos et al. [95] published an adjoint-based constrained topology optimization for viscous flows, including heat transfer.
\n
Zhuang and Xiong [96] proposed a new compliance measure for transient heat conduction problems. They have suggested that the peak values of the given compliance during the time iterations are to be minimized. SIMP with MMA utilized for this study. The equivalent static load-based topology optimization for transient problems was deemed to be more practical and computationally efficient. Cheng and Chen [97] introduced a non-constrained formulation with a volume-of-solid (VOS) function to represent the bounds of the domain. This work is interesting since the objective function was defined as the heat-transfer index (Q˙/m). Oevelen and Baelsmans [98] demonstrated solutions to a conjugate heat-transfer problem using a two-layer-reduced model to represent a full-3D solution. A test case considered Stokes flow and a highly branching flow network was obtained. SIMP interpolation scheme was used. They have acknowledged the artificial flow through a solid network if the penalization for the flow equations is not sufficient. They have further explored the effects of target temperature and bottom-layer thickness. Dede et al. [99] utilized topology optimization in the design and justification of novel structures that can shield, focus or reverse heat flux over a target domain. Anisotropic material constituents utilizing two-phase material microstructure descriptions for non-symmetric inclusions embedded in a matrix medium were manipulated to obtain the desired performance of the structures. Results were compared with a test case and extensions to arbitrary geometries were explored. Alexandersen et al. [100] made tremendous efforts for investigating heat topology optimization considering buoyancy forces. In this situation, the strongly coupled physics phenomena are very hard to model and thus making topology optimization for this kind of systems even more cumbersome. They have utilized SIMP interpolations for some of the material properties and density-based methods were sought for their implementations. They have demonstrated that effects of buoyancy affect the generated design significantly and have presented a natural convection heat exchanger as well as a buoyancy-driven micro-pump. In their paper, elements of large-scale simulations are already evident and they mentioned the difficulties they have encountered as well as their proposed solutions to overcome them. Lee [101] presented a multi-material heat conduction problem using a multiphase level set. Jing et al. [102] presented the topological sensitivity of the objective function on morphing boundaries.
\n
Yaji et al. [103] utilized the level-set method to obtain the optimal design for a fully coupled thermo-fluidics problem. Tikhonov-based regularization scheme enabled the qualitative control for the geometric complexity of the generated structures. An optimization algorithm together with a smoothed Heaviside function was needed for the stabilization of the numerical computations. In this paper, both 2D and 3D examples were demonstrated with smooth and well-defined boundaries. Zhuang and Xiong [104] introduced additional temperature constraints on a defined region in the design domain. Their work had considered transient problems and had utilized the equivalent temperature field as a more effective means to solve the time-dependent finite element problem. In addition, they have utilized three materials in some of their examples using SIMP method. Jing et al. [105] utilized the BEM for the implementation of level-set method and considers design-dependent boundary conditions. The level-set method is used to represent the structural boundary and the boundary mesh for the BEM analysis is constructed on the iso-surface of the level-set function. Topological derivative is also utilized to make new holes. Cheng and Chen [106] utilized their volume-of-solid method for the topological design of the laminated metallic composite materials arranged in two predefined configurations. Similar to the previous paper, they have presented two new very interesting objective functions (Q˙/V and Q˙/USD). Dede et al. [107] recently demonstrated a complete product cycle development for developing a forced air-cooled heat-sink-made additive manufacturing (AM). They have applied SIMP-based topology optimization and had utilized a modified hat function to define the heat convection loading surface for their problem. A parabolic distribution of the heat-transfer coefficient was assumed in relation to the forced air cooling. Two-dimensional models are first tested and compared to some common heat-sink geometries found in the market. A quarter of a 3D model was then implemented and volume reconstruction was also mentioned to obtain a water-tight design suitable for additive manufacturing. Experiments were then conducted and the topology-optimized structures are compared with the commercially available design. Results showed that the designed heat sink performed better compared to other heat sinks but due to the inferior material properties and porous structure of the AM-produced design, it was not performing as to its numerical design specifications. Alexandersen et al. [108] recently published the culmination of their buoyancy flow works by implementing a large-scale three-dimensional model of designed heat sinks. A total of 16.38 million design elements with 83.08 million degrees of freedom were solved in one of their examples for a passive heat-sink cooler for light-emitting diodes (LEDs). Lohan et al. [109] presented generative design algorithms for heat conduction. A dissertation study utilizing boundary element method was recently finished by Jing [109]. Dede [110] designed and fabricated a multi-device single-phase-branching microchannel cold plate.
\n
In this time period, highlight is given to product design cycles and actual realization of topology-optimized designs. It is also evident that trends are going for incorporation of fluid flow either directly (through coupled analysis of both the fluid and heat-transfer domains) or indirectly (through convection boundary conditions). Interests for transient problems have also re-emerged with techniques such as the equivalent temperature field being utilized to reduce the burden of the finite analysis for the governing equations of the system. Level-set method is also evolving rapidly by utilizing other techniques such as topological derivative and BEM to make up for their weak points. Density-based methods, especially SIMP, are still staple with most of the works for 3D modelling and thermo-fluidic systems. Massive implementations with millions of DOFs are also slowly being realized, mostly utilizing density-based methods. As an additional foresight, it can be mentioned that none of the above works have considered radiation effects, though some problem formulations can accommodate radiation by utilizing the convection form of radiation. In the future, this work could be sought but would pose the problem for the discretized method of properly identifying cavities and formations inside the evolving domain. View factor computation is also one complication which would be very expensive to perform since radiating boundaries would change in each iteration.
\n
5. Conclusion
\n
In this chapter, we have re-introduced topology optimization with special focus on the progress of heat exchanger design over the past two decades. We have first given an overview of its historical background in terms of structural topology optimization. We have then conceptually introduced the different methods developed over the years in topology optimization. Learning references for each of the methods mentioned, together with MATLAB codes, were cited and is expected to help those who are interested in further learning and investigating topology optimization. A chronological review highlighting the different progress over the years related to heat exchanger design was also given.
\n
Novel heat-transfer structures are still being realized to further drive design performance to its limits. Topology optimization, as a physics-based and automated layout optimization method, will indeed serve as a valuable design tool for heat-transfer systems. Heat exchanger designs arising from topology optimization has now been realized and continuous efforts are still being made to further improve both methods and implementation. Topology optimization is expected to play a bigger role in the coming years for heat exchanger design.
Symbols and variables (in the order of appearance)
\nμ
Dimension control parameter in homogenization method
\nθ
Orientation control parameter in homogenization method
\nρ
Density variable for density-based topology optimization, material density
\nc
Standard variable for the design objective or compliance, material-specific heat
\nT
Temperature
\nk
Thermal conductivity
\nq
Heat flux
\nn
Boundary normal vector
\nh
Convection heat-transfer rate
\nΩ
Domain
\nt
Time
\nΓ
Boundaries
\nv
Virtual temperature field
\na
Energy bi-linear form
\nl
Thermal load linear form
\nx
Design variable
\nV
Volume
\nT˜
Test temperature vector
\nH
Sobolev space
\nT
Temperature vector in heat-transfer TO
\nK
Global stiffness matrix for FEA
\nQ
Applied thermal load in heat-transfer TO
\nk
Global stiffness matrix for FEA
\nλ
Langrangian multiplier
\n
Subscripts
\n0, 1, 2, .., i
Standard discrete numerical counter
\ne
Element in discretization
\nmat
Material
\nmin
Minimize/minimummax
\nt
Time, to imply transient case in derivation
\nv
Per unit volume, in derivation
\nb
Imposed boundary condition, w/temperature in derivation
\neff
Effective, used with thermal conductivity, k
\np
Penalty parameter for SIMP
\n',keywords:"topology optimization, heat transfer, heat exchanger",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/53653.pdf",chapterXML:"https://mts.intechopen.com/source/xml/53653.xml",downloadPdfUrl:"/chapter/pdf-download/53653",previewPdfUrl:"/chapter/pdf-preview/53653",totalDownloads:3429,totalViews:1072,totalCrossrefCites:1,totalDimensionsCites:2,totalAltmetricsMentions:3,introChapter:null,impactScore:1,impactScorePercentile:55,impactScoreQuartile:3,hasAltmetrics:1,dateSubmitted:"April 12th 2016",dateReviewed:"November 16th 2016",datePrePublished:null,datePublished:"April 27th 2017",dateFinished:"December 26th 2016",readingETA:"0",abstract:"Topology optimization is proving to be a valuable design tool for physical systems, especially for structural systems. However, its application in the field of heat transfer is less evident but is constantly progressing. In this chapter, we would like to introduce topology optimization in the context of heat exchanger design to the general reader. We also provide a chronological review of available literature to see the current progress of topology optimization in the field of heat transfer and heat exchanger design. We expect that topology optimization will prove to be a valuable tool in heat exchanger design for the coming years.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/53653",risUrl:"/chapter/ris/53653",book:{id:"5395",slug:"heat-exchangers-design-experiment-and-simulation"},signatures:"Mark Christian E. Manuel and Po Ting Lin",authors:[{id:"188800",title:"Prof.",name:"Mark Christian",middleName:null,surname:"Manuel",fullName:"Mark Christian Manuel",slug:"mark-christian-manuel",email:"marchm.090407@gmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"Manila Central University",institutionURL:null,country:{name:"Philippines"}}},{id:"203597",title:"Associate Prof.",name:"Po Ting",middleName:null,surname:"Lin",fullName:"Po Ting Lin",slug:"po-ting-lin",email:"potinglin223@gmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"National Taiwan University of Science and Technology",institutionURL:null,country:{name:"Taiwan"}}}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Topology optimization methods and learning codes",level:"1"},{id:"sec_2_2",title:"2.1. Homogenization method",level:"2"},{id:"sec_3_2",title:"2.2. ‘Hard-kill’ methods",level:"2"},{id:"sec_4_2",title:"2.3. Boundary variation methods",level:"2"},{id:"sec_4_3",title:"2.3.1. Level-set method",level:"3"},{id:"sec_5_3",title:"2.3.2. Phase-field method",level:"3"},{id:"sec_7_2",title:"2.4. Density-based methods",level:"2"},{id:"sec_9",title:"3. The heat-transfer problem in the context of topology optimization",level:"1"},{id:"sec_10",title:"4. Chronology",level:"1"},{id:"sec_10_2",title:"4.1. Prior to 2005",level:"2"},{id:"sec_11_2",title:"4.2. 2005–2010",level:"2"},{id:"sec_12_2",title:"4.3. 2011–2015",level:"2"},{id:"sec_14",title:"5. Conclusion",level:"1"},{id:"sec_14_2",title:"Nomenclature\nAbbreviations",level:"2"}],chapterReferences:[{id:"B1",body:'Bourdin, B. and A. Chambolle, The Phase-Field Method in Optimal Design, in IUTAM Symposium on Topological Design Optimization of Structures, Machines and Materials: Status and Perspectives, M.P. Bendsøe, N. Olhoff, and O. 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Journal of Mechanical Design, 2011. 133(3): p. 031011.'},{id:"B81",body:'Zhang, Y., Qiao, H., and Liu S., Design of the heat conduction structure based on the topology optimization in Developments in Heat Transfer. 2011, Croatia: INTECH Open Access Publisher. p. 523–536.'},{id:"B82",body:'Li, J.C., et al. Heat conduction structural topology optimization based on RAMP. in Applied Mechanics and Materials. 2011. Trans. Tech.'},{id:"B83",body:'Papoutsis-Kiachagias, E., et al., Constrained topology optimization for laminar and turbulent flows, including heat transfer, in Evolutionary and Deterministic Methods for Design, Optimization and Control. 2011, EUROGEN, Capua, Italy.'},{id:"B84",body:'Marck, G., et al., Topology optimization using the SIMP method for multiobjective conductive problems. Numerical Heat Transfer, Part B: Fundamentals, 2012. 61(6): p. 439–470.'},{id:"B85",body:'Dede, E.M., Optimization and design of a multipass branching microchannel heat sink for electronics cooling. Journal of Electronic Packaging, 2012. 134(4): p. 041001.'},{id:"B86",body:'Gregersen, M.M., Evgrafov, A. and Sorensen, M.P., Finite volume based topology optimization of coupled fluid dynamic and thermal conduction systems, in Conference on Industrial Design Optimisation for Fluid Flow. 2012, FLOWHEAD: Munich.'},{id:"B87",body:'Lee, K., Topology optimization of convective cooling system designs. 2012, Diss. The University of Michigan.'},{id:"B88",body:'Koga, A.A., et al., Development of heat sink device by using topology optimization. International Journal of Heat and Mass Transfer, 2013. 64: p. 759–772.'},{id:"B89",body:'Burger, F.H., Dirker, J. and Meyer, J.P., Three-dimensional conductive heat transfer topology optimisation in a cubic domain for the volume-to-surface problem. International Journal of Heat and Mass Transfer, 2013. 67: p. 214–224.'},{id:"B90",body:'Zhuang, C., Xiong, Z. and Ding, H., Topology optimization of the transient heat conduction problem on a triangular mesh. Numerical Heat Transfer, Part B: Fundamentals, 2013. 64(3): p. 239–262.'},{id:"B91",body:'Dirker, J. and Meyer, J.P., Topology optimization for an internal heat-conduction cooling scheme in a square domain for high heat flux applications. Journal of Heat Transfer, 2013. 135(11): p. 111010.'},{id:"B92",body:'Marck, G., Nemer, M. and Harion, J.-L., Topology optimization of heat and mass transfer problems: laminar flow. Numerical Heat Transfer, Part B: Fundamentals, 2013. 63(6): p. 508–539.'},{id:"B93",body:'JING, G., et al., Topology optimization for 2D heat conduction problems using boundary element method and level set method. Transactions of JASCOME, 2013. 13: p. 6.'},{id:"B94",body:'Matsumori, T., et al., Topology optimization for fluid–thermal interaction problems under constant input power. Structural and Multidisciplinary Optimization, 2013. 47(4): p. 571–581.'},{id:"B95",body:'Kontoleontos, E., et al., Adjoint-based constrained topology optimization for viscous flows, including heat transfer. Engineering Optimization, 2013. 45(8): p. 941–961.'},{id:"B96",body:'Zhuang, C. and Xiong, Z., A global heat compliance measure based topology optimization for the transient heat conduction problem. Numerical Heat Transfer, Part B: Fundamentals, 2014. 65(5): p. 445–471.'},{id:"B97",body:'Cheng, C.-H. and Chen, Y.-F., Topology optimization of heat conduction paths by a non-constrained volume-of-solid function method. International Journal of Thermal Sciences, 2014. 78: p. 16–25.'},{id:"B98",body:'Van Oevelen, T. and Baelmans, M., Application of topology optimization in a conjugate heat transfer problem. in 1st International Conference on Engineering and Applied Sciences Optimization. 2014. OPT-i 2014.'},{id:"B99",body:'Dede, E.M., Nomura, T. and Lee, J., Thermal-composite design optimization for heat flux shielding, focusing, and reversal. Structural and Multidisciplinary Optimization, 2014. 49(1): p. 59–68.'},{id:"B100",body:'Alexandersen, J., et al., Topology optimisation for natural convection problems. International Journal for Numerical Methods in Fluids, 2014. 76(10): p. 699–721.'},{id:"B101",body:'Lee, D., Topology optimization of multi-material with heat conduction problem in Proceedings of the 5th European Conference of Computer Science (ECCS 2014). 2014, Switzerland: WSEAS press. p. 54–55'},{id:"B102",body:'Jing, G., et al., Topological sensitivity of the objective function defined on morphing boundaries of two-dimensional heat conduction problems. Boundary Elements and Other Mesh Reduction Methods, 2014. 57: p. 3.'},{id:"B103",body:'Yaji, K., et al., A topology optimization method for a coupled thermal–fluid problem using level set boundary expressions. International Journal of Heat and Mass Transfer, 2015. 81: p. 878–888.'},{id:"B104",body:'Zhuang, C. and Xiong, Z., Temperature-constrained topology optimization of transient heat conduction problems. Numerical Heat Transfer, Part B: Fundamentals, 2015. 68(4): p. 366–385.'},{id:"B105",body:'Jing, G., et al., Level set-based topology optimization for 2D heat conduction problems using BEM with objective function defined on design-dependent boundary with heat transfer boundary condition. Engineering Analysis with Boundary Elements, 2015. 61: p. 61–70.'},{id:"B106",body:'Cheng, C.-H. and Chen, Y.-F., Topology optimization of conduction path in laminated metals composite materials. International Journal of Thermal Sciences, 2015. 96: p. 183–190.'},{id:"B107",body:'Dede, E.M., Joshi, S.N. and Zhou, F., Topology Optimization, Additive Layer Manufacturing, and Experimental Testing of an Air-Cooled Heat Sink. Journal of Mechanical Design, 2015. 137(11): p. 111403.'},{id:"B108",body:'Alexandersen, J., Topology optimisation of passive coolers for light-emitting diode lamps. 11th World Congress of Structural and Multidisciplinary Optimisation, 2015.'},{id:"B109",body:'Jing, G., A study on topology optimization for two-dimensional steady-state heat conduction problems using Boundary Element Method. 2015, Nagoya University: Japan.'},{id:"B110",body:'Dede, E.M., Design optimization of a multi-device single-phase branching microchannel cold plate. Electronics Cooling Magazine. 2015.(3): p. 14–17.'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Mark Christian E. Manuel",address:"marchm.090407@gmail.com",affiliation:'
School of Mechanical and Manufacturing Engineering, Mapua Institute of Technology, Manila, Philippines
Mechanical Engineering Department, Chung Yuan Christian University, Chungli City, Taoyuan, Taiwan
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1. Introduction
Humic substances (HSs) are organic compounds derived during the humification process of decaying plants and animals and are mainly composed of humic acid (HA) and fulvic acid (FA). HSs have been utilized in humans for ages as nutritional supplements and therapeutic purposes. The first mentions of the therapeutic applications of HS may be found in Sanskrit and ancient Chinese and Roman texts, where they were assigned magical properties [1, 2]. Some of the therapeutic characteristics of HS are mentioned in the Chinese Materia Medica Pharmacology Compendium, which dates back to the Ming Dynasty in the fifteenth century; their medicinal usage was permitted by the China Drug Administration, and they were known as “the gold of medicine” in China [3]. Another important medical application of HS is its usage in balneotherapy in ancient Babylon, in Lower Mesopotamia and in the Roman Empire [4]. Information about the use of HSs in humans has recently been published, including medical issues, preclinical trial outcomes, and successful clinical therapies [5, 6, 7].
HSs are molecules with anti-inflammatory, antioxidant, antiparasitic, antibacterial, and antiviral properties, according to the European Agency for the Evaluation of Medicinal Products’ Committee for the Evaluation of Veterinary Products [5, 8], and the feasibility of using them orally in horses, dogs, pigs, and birds in doses of 500 to 2000 mg/kg of live weight for the treatment of diarrhea, dyspepsia, and acute poisoning was documented; it was also indicated that HSs exert a protective action on the mucosa of the intestine and have antiphlogistic, adsorbent, antitoxic, and antimicrobial properties.
The various structures and functional groups give HS properties such as colloidal, spectral, electrochemical, and ion exchange, which confers significant adsorption capacity [5, 9]. HS has been shown in animals to be able to modulate the harmful effects of a variety of xenobiotics and unwanted compounds that enter the digestive tract through feed and drinking water due to their colloidal properties and propensity to form chelates [10, 11]. HS has also been shown to minimize the accumulation of some heavy metals in tissues, including mercury, cadmium, and zinc in fish [12], lead and cadmium in rats [13], and cadmium, zinc, and lead in chickens [9, 10, 11]. The main research findings and some proposed theories about the mechanism of action of HS in animals are discussed in the following sections. Figure 1 summarizes the main benefits observed in animals provided HS.
Figure 1.
Main benefits observed in animals provided humic substances.
2. Formation of protective layers in the digestive mucosa
Due to their colloidal characteristics and high capacity to form aggregates within solutions, it has been proposed that HSs have the ability to create protective layers on the epithelial mucous membrane of the digestive tract, preventing the penetration of pathogenic bacteria or toxic substances produced by bacteria [8, 14, 15]. The ability of HS to form polymers in a media with a slightly alkaline pH, such as the intestine, is credited with the creation of protective barriers [16]. HS also interacts with biomolecules like collagen, promoting the resistance and maturity of its fibers, resulting in an increase in the intestinal villi’s integrity [17].
HSs were found to increase intestinal viscosity, inhibit bacterial translocation from the intestine to the liver, and lower the serum levels of an intestinal permeability marker, fluorescein isothiocyanate dextran (FITCd), in a recent study [15]. HS has also been demonstrated to positively regulate mucine-2 (MUC-2) gene expression in the cecum mucosa [18]. MUC-2 is a main gel-forming mucin that serves as the principal barrier component of mucus layers as well as a storage location for secretory immunoglobulin A (IgA). The number of goblet cells in the villi of the jejunum of broiler chickens fed with HS was similarly found to be increased 24 hours following a diet change challenge [19]. HS may increase the protective mucus layer in the small intestine, allowing the villi to maintain their integrity against pathogenic agents, toxins, and dietary changes, according to this research. In addition, the development of gels causes increased viscosity in the small intestine, which results in slower rate of feed passage through the gut [20, 21], which increases the time of exposure of nutrients to digestive enzymes [22, 23].
The protective effect of HS on the digestive epithelium has been associated with increases in villus height, crypt depth, and epithelial surface area in mice [17], chickens [24, 25, 26], Japanese quails [27], and rabbits [28], and increased activity of digestive enzymes in the digestive mucosa of chickens [26, 29] and freshwater fish [30], and also to increased energy and protein digestibility in chickens [31, 32], organic matter, protein, and fiber in rabbits [28, 33] and protein in milking cows [34]. In addition, an increased weight of the gizzard and length of the duodenum and jejunum has been reported in chickens fed canola-based diets and added with HS [35], as well as the size and weight of the cecum of rabbits [28].
It has been proven that peat-based treatments can be used to relieve gastric, intestinal, and liver diseases [36]. Peat moss has been proven to minimize the size of ethanol-induced stomach ulcers in rats, speeding up the healing process of both gastric and duodenal ulcers [37]. Orally administered HS to rats has been shown to bind, presumably metabolize, and resorb toxins in the gastrointestinal system [38]. These results supported the orally administration of HS to animals for the treatment of diarrhea, dyspepsia, and acute poisoning [8, 39]. In recent research, pigs [40, 41, 42] and calves [43, 44, 45] fed with HS showed less severe diarrhea.
In addition to the benefits of HS observed on the mucosal surface of the digestive tract, healing and protective effects have also been reported on other types of epithelia. The restorative effect of HS on the epidermis has been demonstrated with balneotherapy, which is used for the treatment of various skin diseases such as chronic eczema, neurodermatitis, and psoriasis in various parts of the world [2], in which the activation of skin metabolism and regenerative processes has been observed [5].
On the other hand, the plethoric benefits that have been widely documented in the immune response, antioxidant status, digestive microbiology, and nutrient metabolism in humans and animals added with HS suggest that the mechanisms of action go far beyond its mucosal protective effect. It has previously been suggested that the absorption of orally administered HS is very low, at 0.05 to 0.07% [8]. But in subsequent evaluations, it has been reported that HS can be absorbed and transported to other tissues of the body. In young pigs, HS particles were observed in all segments of the small intestine and in lymph nodes associated with the intestine, and in urinary bladder and trachea [46]. In adult pigs, it was not possible to confirm these findings [47]. However, in older studies using 125I-HA, distribution of HA was observed in several tissues, notably the skin, blood serum, liver, muscle, and digestive tract of rats [48].
In several studies in which hepatotoxicity was induced using lipopolysaccharide (LPS), carbon tetrachloride, and ethanol in rats given HS orally by gavage, the protection against liver injury was confirmed, due to reduced serum levels of aspartate aminotransferase (AST), alanine transaminase (ALT), and alkaline phosphatase (ALP) [49, 50, 51]. The medical benefits of HS offered orally against different types of musculoskeletal and gynecological diseases as well as for the treatment of heart and liver conditions have been reviewed in other documents [2, 5]. In the following sections, the main results of the use of HS on the antioxidant status, immune response and inflammation, digestive microbiota, use of minerals, proteins, and energy, and the growth performance parameters in animals are reviewed. For information about the benefits of HS in aquaculture, it is recommended to review other scientific publications in this area [52, 53, 54].
3. Antioxidant status
The redox properties of HS have been investigated in in vitro and in vivo studies, with quinones being classified as reducible fractions and phenols being classified as electron-donating fractions with antioxidant properties in comparison with electron-accepting quinones, respectively [55, 56]. The neuroprotective, cardioprotective, and renoprotective properties of HS in rats have been already described [2]. In all cases, the total oxidative status and oxidative stress index levels were significantly decreased, and total antioxidant status was increased in the HS experimental groups. The hepatoprotective properties of HS have also been long recognized. In studies with rats in which hepatotoxicity was created using different challenge models, such as administration of LPS, carbon tetrachloride and ethanol, the oral feeding of HS elicited increased glutathione (GSH) and superoxide dismutase (SOD) activities and decreased a marker of lipid peroxidation, malondialdehyde activity (MDA) [49, 50, 51].
In broiler chickens supplemented with HS, a potent antioxidant activity such as increased glutathione reductase (GSH-Rx), total antioxidant capacity (T-AOC), and catalase activity in the blood has been reported [57]. In broilers supplemented with increasing dietary FA, increased SOD and glutathione peroxidase (GSH-Px) activity and decreased MDA levels in the blood were also found in a recent study [29]. On the contrary, in the liver of HS-added broilers, reductions of the SOD were found, whereas in the mitochondria of the muscle lower MAD, SOD and higher catalase were found [58]. It was suggested that the difference of SOD activity in serum versus the liver and mitochondria from muscles may be due to their ability to recombine with intermediate free radicals that may lead to partly inactivation of the enzyme [59]. In broilers supplemented with HS and subjected to transportation stress, increased SOD and GSH-Rx activities in the mitochondria of the liver were observed [60]. In breast meat and thighs of HS-added chicken, decreased lipid oxidation was reported, especially after the fourth day of storage after slaughter [61]. Similarly, an increase of MDA, lightness and yellowness were observed in breast meat after 7 days of storage [62]. In red blood cells of HS-added hens, reduced levels of MDA, GSH-Px, glutathione-S-transferase, γ-glutamyltransferase and oxidized glutathione and increased levels of GSH-Rx, reduced glutathione and the ratio of reduced glutathione/oxidized glutathione were found [58].
In HS-added weaned pigs, reduced T-AOC and MDA were observed [63]. In piglets born from HS-added sows 2 weeks before and 1 week after farrowing, reduced TBA-active products concentration, lipid hydroperoxides, and protein carbonyl groups and increased SOD and catalase activity were found; after re-feeding HS in the older piglets, reinforced positive impact on the antioxidant defense system and free-radical processes were reported [64]. In HS-added weaning pigs, a decrease in oxidative stress was also reported after a challenge with an Escherichia (E.) coli LPS [65]. In HS-added calves, higher serum GSH-Px and T-AOC activities and lower diamine oxidase (DAO) and MDA concentrations were observed [44]. Later on, higher total SOD and T-AOC activities and lower MDA concentrations were confirmed in HS-added calves [45].
It has been suggested that decreased activity of SOD was connected with the antioxidant properties of HS that decreased the concentration of oxidized products, including superoxide anion [58]. Another possible way to activate the enzymatic activity of the antioxidant system is to increase the concentration of metals in the liver, which are part of the active centers of metal proteins: Zn—catalase, Mn (Cu/Zn)—superoxide dismutase [59]. The lower fat content in the meat of HS-added broilers and pigs may elicit a higher proportion of antioxidant components and could have an effect on the higher oxidative stability [62].
4. Immune response and inflammation
HSs have been shown to exhibit different immunostimulatory and immunomodulatory effects in patients with different infectious diseases, which have been associated with their anti-inflammatory properties [2, 5, 6]. It seems that HSs form solid complexes with carbohydrates, which allow the formation of glycoproteins with the ability to bind to natural killer cells and T lymphocytes and allow subsequent communication between these cells [66].
HS has been shown to stimulate the immune response in broilers [8, 67, 68]. For example, elevated lymphoid tissue distribution and density in the bursa of Fabricius and thyme [25] increased concentration of antibodies against infectious bursal disease [69], avian influenza [70], and Newcastle disease virus (NDV) [71, 72], and greater lymphocytes and leukocytes counts, globulins (α, β, and γ), phagocytosis, and phagocytic index have been found in HS-added broilers [73]. In laying hens, supplementation HS significantly increased the serum IgG and IgM level [74].
In weaned and growing pigs supplemented with HS, increased percentage of lymphocytes and activity of neutrophils has been reported [41, 75]. In HS-added weaned pigs, increased level of IgM and IgG and reduced concentration of inflammatory factors such as tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) and IL-1, myeloperoxidase, and DAO were observed [63]. In HS-supplemented calves, higher IgA and IgG concentrations, lower TNF-α [43, 44] and higher serum IgA, IgG, and IL-4 concentrations, and lower IL-6 and TNF-α were observed [45].
The enhanced immune response in HS-added animals may be the cause of the reduced severity of diarrhea reported in pigs [40, 41, 42] and calves [43, 44, 45] and to the strong tendency of lower mortality reported in broilers [25, 67, 76, 77], Japanese quails [27], and pigs [41, 78].
5. Digestive microbiota
Reports from the microbial, geo, soil, and environmental sciences indicate that HS stimulates the growth and diversity of soil and environmental fungi and bacterial communities [79, 80]. A review of the main ways of action of HS on biota was previously reported [81]. The most outstanding mechanisms of HS on the activity of microorganisms are a) as a source of substrates, providing carbon, nitrogen, phosphorus, trace elements, and vitamins [82], and b) as natural surfactants, increasing the permeability of cell membranes in bacteria, due to their amphiphilic character, which enhances the absorption of nitrogen and other micronutrients [83]. Examples of some aerobic HS-degrading bacteria are Pseudomonas spp., Streptomyces spp., Bacillus (B.) brevis, B. cereus and Alcaligenes faecalis, among others [81, 84]. In one report, the anaerobic decomposition of HS by Clostridium (C.) spp. was also reported [79]. The recovered HS from the bacterial cultures show some modifications such as losses of aliphatic structural units and gains of aromatic structures under aerobic conditions [85], while under anaerobic conditions removal of carboxyl groups and polysaccharide-related substances and gains of aliphatic components, amide and aromatic groups have been observed [79]. Furthermore, it has been suggested that differences of the microbial degradability of HS are associated with differences of their chemical composition and the bacterial species.
All these factors are probably associated with the contrasting microbiological results reported under in vitro experiments in which different types of bacteria are cultured with HS or in in vivo experiments in which the feed or water of broiler chickens are added with HS. In an in vitro study, in which natural and synthetic HS were tested, the spectrum and degree of antimicrobial activity against many human pathogenic bacteria varied according to the origin, extraction mode of the HS, and the tested bacterial strain [86]. In another in vitro report, natural HS showed insignificant inhibition of the growth of bacteria such as E. coli and Salmonella (S.) Enteritidis, but the modified HS caused reductions from 78 to 80% and 58 to 70% of the number of colonies of E. coli and S. Enteritidis, respectively [87].
In HS-added broiler, no significant effects of HS have been reported on the total Gram-negative bacteria [15] or the anaerobic bacterial populations in the ceca [88, 89], while reductions of enterobacteria in the small intestine and cecum were found in one study [18]. Lower E. coli counts in the digesta content from the small intestine and ceca [71] and higher E. coli counts between 10 and 100 times) in the ceca content [88] have been also reported. Furthermore, the addition of HS in broilers did not reduce the counts of Clostridium perfringens, S. Enteritidis, and E. coli in the gut [15, 90, 91, 92]. Opposite to this, in Japanese HS-added quails, reductions in E. coli, coliforms, and C. perfringens of the intestinal content were found [27].
Some differences observed on the antimicrobial effects of HS in in vitro studies may be due to the use of different sources and dosages of the tested products, the length of the incubation period, and hence, the duration of the bacterial exposure to the products, the temperature and pH conditions, and the nutritional composition of the culture broth. In contrast to this, the total passage time of feed through the gastrointestinal tract in chickens lasts between 3 and 4 h [93], and only during this short period of time, the bacteria is exposed to HS; the core temperature of chickens is about 40°C and the pH varies in the range 4.5–5.9, 2.0–3.0, and 5.5–7.0 in the crop, proventriculous, and intestine, respectively [94]. The microbiota that resides in the digestive tract feeds on the nutrients released from the feed as digestion proceeds and on the endogenous secretions associated with the different compartments. In in vitro experiments, a cytotoxic effect of HS against many mammalian and bacterial cells has been demonstrated due to the accumulation of free radicals during long-term culture times, inducing lower oxygen uptake, lower electron transfer to acceptors, and lipid peroxidation in cell membranes [95]. It is probably that in some long-term in vitro experiments, the antimicrobial activity of HS was due to the accumulation of toxic metabolites in the culture. This effect may be precluded in the gastrointestinal tract.
In a recent study, the addition of HA extracted from worm compost in an in vitro chicken digestive system caused, in the simulated crop, increasing counts of E. coli, C. perfringens, Lactobacillus (L.) salivarius, and B. subtilis as the concentration of HA increased. In the simulated proventriculus, the counts of S. Enteritidis, E. coli, and B. subtilis were enhanced at the higher level of HA. In the simulated intestine, HA increased the counts of S. Enteritidis, E. coli, C. perfringens, and B. subtilis. The results suggest that HA can be used by bacteria as substrates, since they are organic sources of carbon, nitrogen, phosphorus, and other nutrients. HA can also improve nutrient assimilation, as probably occurred during the experiments as bacterial counts were increased. It is probably that in the simulated digestive system the rapid transit time through the digestive compartments, the addition of the buffering solutions and the presence of several dietary components in the intestine overcome the possible accumulation of toxic metabolites [96]. In two recent in vivo studies, increased lactic acid bacteria counts were reported in the gut of HS-added broilers [77, 91].
In weaning pigs supplemented with HS, lower relative abundance of Firmicutes, Bacteroides, Anaerovibrio, Oscillospira, and Ruminococcus and a trend toward higher abundance of Prevotella in feces were reported compared to control pigs [41]. Also in HS-added weaned pigs, reduced short-chain fatty acids (SCFAs), gas formation, and microbial alpha diversity and no changes in the microbiome of the cecal and colon content were found [97].
In weaned Holstein HS-added calves, increased ratio of Firmicutes to Bacteroidetes and relative abundance of Firmicutes and decreased relative abundance of Bacteroidetes were reported [43]. In addition, a correlation analysis indicated that Bifidobacterium, Lactobacillus, and Olsenella were positively correlated with IgG, weight gain, and GSH-Px and negatively correlated with MDA, DAO, and fecal score, respectively, which might explain that HS inclusion could improve growth performance, anti-inflammatory, and antioxidative status and alleviate diarrhea of weaned calves via increasing the abundance of intestinal beneficial microbiota, and that upregulated fatty acid metabolites were positively correlated with increased beneficial intestinal microbiota [43]. In two additional research, HS supplementation increased the abundances of Bifidobacterium and Lactobacillus but decreased the abundance of E. coli in feces of calves [44, 45]. In HS-added goats, for 14 days prepartum and 56 days postpartum, increased ruminal acetate and propionate concentrations but reduced protozoa counts were observed [34, 98]. In growing HS-added rabbits, the total bacteria and E. coli counts in cecum were decreased [28]. Also in HS-added rabbits, increased concentrations of propionic and butyric acids were found [33].
It was previously suggested that within the body, HSs stimulate the good microbes while suppressing the bad microbes, and that HSs stabilize the intestinal flora thus ensuring an improved utilization of nutrients in animal [67]. Recent results in broiler chickens, pigs, calves, goat and rabbits seem to confirm this suggestion. Several of the aforementioned authors agree in that HSs cause a shift in the digestive microbiota by stimulating the growth of probiotic-type bacteria and modifying the microbial fermentation in nonruminant and ruminant animals, leading to the formation of a greater amount of SCFA, which reduces the pH of the medium and probably inhibits the growth of potentially pathogenic bacteria. In addition, some of the SCFAs found have a trophic effect on the digestive mucosa. The increased beneficial flora, reduced potentially pathogenic bacteria, and stimulated growth of intestinal villi have been associated with better intestinal health and improvements in the processes of digestion, including increased activity of different digestive enzymes. This provides excellent nutritional feed conversion efficiency which aids in body weight gain without increasing the amount of feed consumed.
5.1 Antiparasitic effects
In the area of aquaculture, experiments with goldfish (Carassius auratus) and common carp (Cyprinus carpio) under pond culture conditions, a HS bath caused reduction of infections of skin and gills by protozoan parasites and dropping of infections of the gills caused by Ichthyophthirius spp. [52]. In other studies, similar findings in HS exposed fish, ornamental fishes, and Nile tilapia were reported [53, 99]. In experimentally challenged mice with Trypanosoma (T.) brucei brucei and T. brucei gambiense, the administration of HS for 21 days in the drinking water induced adequate protection and significantly reduced the mortality rate, while all non-treated control mice died within 10 days after the challenge [100]. In HS-added goats and dairy cows, reduced ruminal protozoa counts were observed [34, 98]. Using liquid or solid extracts of HS from worm compost, the count of coccidia eggs in the excreta of broilers was reduced, but the results were generally inconsistent [91, 101]. More information is required on this topic.
5.2 Antifungal effects
It has been reported that HSs have a fungicidal effect on Candida (C.) albicans under in vitro conditions [86] and over that inhabiting the gastrointestinal tract of animals and humans [102]. HS was recently found to decrease the toxic effects of aflatoxicosis in broilers [103, 104]. Results of in vitro binding studies showed that HS has a high mycotoxin adsorption capacity; in HS-added broilers and fed aflatoxin-contaminated feeds, a protective effects against liver damage, stomach, and heart enlargement as well as reduction of some of the hematological and serum biochemical changes associated with aflatoxin toxicity were shown [103]. In HS-added broilers, provided with aflatoxin-contaminated feeds, improved feed efficiency and reduced liver and bursa damage as well as reduction of serum AST, ã-glutamyl transferase, and lactate dehydrogenase were observed [104, 105]. Reduced aflatoxin B1 residues in liver and increased NDV antibody titers in 28- and 35-day-old birds [105, 106] were also reported in HS-added broilers. In HS-added weaned pigs, improved weight gain and increased elimination of zearalenone in fecal samples (from 64, 77, and 92%) in a dose-dependent manner as well as recovery of the secretion of β-estradiol were observed [107].
The protective effect of HS against mycotoxicoses seems to involve the sequestration of aflatoxins in the gastrointestinal tract, reducing their bioavailability and increasing their excretion through feces, which reduces damage to the liver and other vital organs, thus promoting better immune response and greater growth in animals that consume feed contaminated with mycotoxins.
6. Metabolism of minerals, proteins, and lipids
6.1 Minerals
HSs are considered as the natural ligands with the highest complexation capacity, giving them a strong potential to form chelates with various ions, which have been linked to better mineral utilization in plants and animals [108]. Increases in ash and Ca content in tibia bone have been reported in broilers fed HS [25, 109, 110]. In the same way, supplementation with liquid extracts of HS from worm compost caused an increase in ash retention in growing chickens [31] and increments in the tibia ashes, Ca and P percentage in 21-day-old broilers as well as in tibia dry matter percentage, and Ca and P content in 42–day-old broilers [111].
The plasma concentrations of Cu, Mn, and Cu and the liver concentration of Cu, Fe, and Se were higher in under normal rearing conditions in HS-added broilers [112]; however after the transportation to the slaughter house, the plasma concentrations of Zn and Mn were decreased, while the Fe and Se were increased as well as the liver concentrations of Zn Cu, Mn, and Se [112]. In HS-added broilers, increases in Ca, P, Fe, and Cu concentrations in the meat [113, 114, 115] and increases in Ca, Mg, Zn, and Fe in the thigh and breast have been reported [116]. These results also agree with the increased percentage, thickness, and hardness of eggshells reported in HS-supplemented laying hens and pheasants [117, 118, 119, 120]. In HS-fed weaned pigs increased serum phosphatase alkaline, Ca, P, and Mg [121]. In the milk of HS-added cows, increased Ca and Fe content [122] and serum Ca levels [123] were found.
In HS-added rabbits, an early increased content of Fe and Ca and late increased activity of ALP and Cu content in serum were observed; additionally, in HS-added rabbits, increased number of layers of osteons and osteoblasts in the bone tissue of the femur, number of osteons and osteoblasts in the bone tissue of the sternum, number of columns of chondrocytes, and number of chondrocytes in the column in the cartilaginous tissue of the sternum were found [124].
6.2 Proteins
It has been suggested that protein utilization efficiency is improved in nonruminant and ruminant animals supplemented with HS. In HS-added broiler chickens, increased total body mass [125, 126] and serum and tissue protein contents [127] were previously reported. These results agree with the higher protein efficiency ratio [128], breast and thigh meat and total protein content [62, 102, 129], and higher carcass and breast yield [35, 91, 102] recently found in HS-added broilers. The addition of HS has also caused increases in protein retention and digestibility in broiler chickens [31, 32] and protein digestibility rabbits [28, 33] and milking cows [34]. In laying hens, HS linearly increased serum total protein, albumin, and globulin [130]. In Holstein-Friesian HS-added cows, the protein and casein contents in milk were increased [122]. In HS-added rabbits, a significant decrease in the concentrations of urea and increase in total blood protein, albumen, and globulin levels have been observed [33, 131].
6.3 Ammonia emissions
Nitrogenous waste, ammonia emissions, and bad odors are reduced in animals supplemented with HS due to improved feed efficiency, digestibility, and nitrogen retention [15, 78, 132]. In HS-added broilers and pigs, reductions of aerial and feces ammonia were observed [15, 78, 133]. It was suggested that the reduction of aerial ammonia in pigs supplemented with HS could be attributed to the inhibition of the urease activity in manure [78]; it is possible that the reduction of the urease activity inside the intestine may have contributed to the greater nitrogen retention and digestibility in HS-added animals. In aquaculture systems, the addition of HS improved the water quality by decreasing the total ammonia nitrogen and nitrate-nitrogen concentration and increased the nitrogen utilization efficiency by changing the microbial communities and strengthening nitrification [54].
Using a rumen stimulation technique and in HS-added goat and dairy cows, linear reductions in ruminal ammonia concentration have been reported [34, 98, 134]. In addition, in HS-added rabbits, the concentration of ceca ammonia decreased sharply in a dose response manner [33]. The lower ruminal or ceca ammonia concentrations may be linked with the effectiveness of HS to reduce ammonia accumulation and also to their strong nitrogen-binding properties of HS. In this way, in ruminant animals, HS may enhance rumen crude protein utilization by decreasing ammonia loss owing to reduced solubility under the inhibitory effects of HS on urease activity [78]. This might cause a shift in nitrogen excretion from urine to feces due to reduced solubility. The ability of HS to alter ruminal fermentability may be linked to ammonia sequestration and then slow release for microbial growth; additionally, reducing protozoa number may increase microbial crude protein flow to the small intestine [34, 98].
6.4 Lipids
In humans, HA and FA preparations are promoted as supplements to increase energy and to reduce fatigue. In a rodent model, a product containing 60–80% HS reversed the negative behavioral symptoms of depression and anxiety caused by chronic fatigue syndrome and also stabilized the HPA axis stress response by reversing the drop in corticosterone levels and adrenal gland weight; it was suggested that the effects of HS were partially due to the regulation of mitochondrial bioenergetics by increasing the activities of mitochondrial NADH dehydrogenase, succinate dehydrogenase, cytochrome oxidase, and ATP synthase.
In the majority of the publish research, it is evident that HS modulates the use of energy toward reductions of the lipid content in chicken and pig meat but increases the milk fat content in cows and goat. In HS-added broilers, reductions of the total lipid content of liver [125] fat content in the breast meat [62, 114, 129] and blood cholesterol levels [68, 110, 135, 136, 137] have been reported. In HS-added broilers and laying hens, HS linearly decreased serum triglycerides and very low-density lipoproteins concentrations [68, 130] and also reduced the cholesterol content in the eggs yolk [138]. In HS-supplemented pigs, reduced backfat has been observed [75, 78, 139]. The findings in pigs seem to be associated with increased activity of the hormone-sensible lipase and reduced activity of lipoprotein lipase in adipose tissue, as has been shown in pigs added with increasing dietary FA [140].
Opposite to this, in dairy cows, increased fat milk content has been found [122, 123, 141, 142] but decreased serum nonesterified fatty acids and blood beta-hydroxybutyric acid levels [123] and serum cholesterol [34] have been seen. In HS-added goats, significantly reduced serum cholesterol concentrations [98, 143] have been reported. Also in HS-added rabbits, reduced total and low-density lipoproteins cholesterol and triglycerides [28, 33, 144, 145] but increased high density lipoproteins [28] have been observed.
7. Productive response in animals supplemented with humic substances
7.1 Poultry
In two recent published articles, more descriptive effects of HS in poultry have been given [68, 96]. In several experiments, enhanced final body weight and weight gain and reduced feed conversion ratio have been reported in HS-added broilers using different commercial sources of HS [24, 68, 113, 114]. In agreement with these results, using a liquid or dry extract of HS from worm compost, higher final body weight and weight gain and lower feed conversion ratio have been reported in broiler chickens [19, 31, 77, 146].
Greater carcass weight and yield have been also observed in HS-added broilers [35, 113, 114, 128], including those supplemented with worm compost-derived HS [91, 146]. In breast and thigh meat, lower water loss and increased lightness and yellowness were observed [62, 129].
In laying hens and partridges supplemented with HS, benefits in feed intake, egg production, egg weight, and feed conversion ratio have been observed [118, 119, 120, 130, 147]. Improved Haugh unit values and egg yolk color in HS-added laying hens [74] and increased albumen height, albumen index, and Haugh units of the egg in partridge [148] were observed. A strong tendency of lower mortality have been reported in HS-added broilers [25, 67, 77] and Japanese quails [27].
7.2 Pigs
In HS-added weaned pigs, improved body weight, weight gain, feed intake, and feed conversion ratio have been reported [41, 42, 63, 121, 149, 150]. In HS-added growing pigs, higher weight gains and feed efficiency have also been reported [75, 78, 139]. Reduced severity of diarrhea [40, 41, 42] and lower mortality [41, 78] were reported in HS-added pigs.
7.3 Ruminants
In HS-added calves, higher body weight and weight gain [43, 44, 45, 142] while in HS-added dairy cows, increased milk production, milk fat, and milk protein were found [122, 123, 141], as well as in dairy goats [145]. Reduced severity of diarrhea has been reported in HS-added calf [43, 44, 45].
7.4 Rabbits
In HS-added rabbits, enhanced body weight, weight gain, and carcass weight but reduced feed conversion ratio have been found [28, 33, 144].
8. Conclusions
The present review reinforces the promoted protective action of HS on the digestive mucosa, their antioxidant properties, immunomodulatory, and anti-inflammatory attributes, the suggested microbial shift to a probiotic-type bacteria in the gut, including antiparasitic and antifungal effects, as well as their influence on the higher efficient of minerals, proteins, and lipids utilization within the body. The sum of all of these effects result in improved health, lower diarrhea and mortality rates, and increased growth rate, feed conversion, meat and milk production, as well as improved animal product quality.
The information reviewed does not allow to clearly define the main mechanism(s) of action of HS due to the plethoric benefits found. It is likely that, in order of importance, the main benefits of HS derive from their ability to form protective barriers on the digestive mucosa, blocking the passage of pathogenic bacteria and bacterial toxins or metabolites that could otherwise damage or invade the mucosal cells of the digestive tract. This also includes other compounds such as mycotoxins, anti-nutritional factors, and other contaminants that could enter the intestine through the diet.
The other no less important benefit is the ability of HS to stimulate the establishment of a beneficial microflora, and a pattern of microbial fermentation that promotes intestinal health, which could reduce the development of potentially pathogenic bacteria, creating a hostile environment, for example, through the production of SCFA, such as lactic, butyric, and propionic acid, which may acidify the intestinal content.
The rest of the benefits of HS within the body, such as enhanced antioxidant and immune status, increased efficiency of mineral, protein, and lipid utilization and improved health and growth and are likely to be dependent on the proposed effects of the digestive tract. However, since the effects on the gut may vary depending on the factors associated with the animal (species, age, and physiological and health status) to the tested HS (origin, age, concentration of functional groups, and composition and length of the side chains) and the experimental design and treatments (dosage, route and form of administration, length of supplementation, type of facilities, and sanitary conditions), the additional effects within the body may significantly differ.
The current research also demonstrates that numerous theories have been presented to account for the infinite number of effects of HS reviewed in this literature survey. With the existing evidence, it is not possible to reach consensus conclusions. The truly molecular mechanisms of action of HS in the intestine and throughout the body remain unknown. However, outstanding improvements in health, productivity, and meat and milk quality obtained from animals supplemented with HS are common features in the majority of available research.
Acknowledgments
This research was supported by the Arkansas Biosciences Institute under the project: Development of an avian model for evaluation early enteric microbial colonization on the gastrointestinal tract and immune function. CONACYT provided funding to carry out several experiments described in this chapter through the project “Efficacy of an extract of humic substances as a growth promoter, reducing infectious diseases and increasing the profitable production of meat of birds and pork” (PDCPN 2017/4777).
Conflict of interest
The authors declare no conflict of interest.
\n',keywords:"humic substances, farm animals, mucosal protection layers, microbiota, antioxidant and immune responses, nutrient utilization, performance",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/82760.pdf",chapterXML:"https://mts.intechopen.com/source/xml/82760.xml",downloadPdfUrl:"/chapter/pdf-download/82760",previewPdfUrl:"/chapter/pdf-preview/82760",totalDownloads:23,totalViews:0,totalCrossrefCites:0,dateSubmitted:"May 31st 2022",dateReviewed:"June 20th 2022",datePrePublished:"July 20th 2022",datePublished:null,dateFinished:"July 20th 2022",readingETA:"0",abstract:"A review of the latest research on the addition of humic substances (HSs) in the drinking water or feed of farm animals including poultry, pigs, dairy cows and calves, goats, and rabbits was carried out. The results reinforces the promoted protective action of HS on the digestive mucosa, their antioxidant properties, immunomodulatory, and anti-inflammatory attributes, the suggested microbial shift to a probiotic-type bacteria in the gut, including antiparasitic and antifungal effects, as well as their influence on the higher efficient of minerals, proteins, and lipids utilization within the body. The outstanding improvements in health, productivity, and meat and milk quality obtained from animals supplemented with HS are common features in the majority of available research. The main benefits in the gastrointestinal tract stem from the formation of protective barriers on the epithelial mucosa due to its colloidal properties and stimulation of mucin production. HS also promotes the development of probiotic microbiota and positive changes in bacterial fermentation patterns, which results in improved intestinal health and integrity. As a result, a cascade of benefits is derived within the body, reinforcing antioxidant protection responses, immunomodulation, and anti-inflammation mechanisms, as well as improving nutrient utilization efficiency. However, the truly molecular mechanisms of action of HS in the intestine and throughout the body remain unknown.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/82760",risUrl:"/chapter/ris/82760",signatures:"María de Lourdes Angeles, Sergio Gómez-Rosales and Guillermo Téllez-Isaias",book:{id:"11615",type:"book",title:"Humus and Humic Substances - Recent Advances",subtitle:null,fullTitle:"Humus and Humic Substances - Recent Advances",slug:null,publishedDate:null,bookSignature:"Prof. Abdelhadi Makan",coverURL:"https://cdn.intechopen.com/books/images_new/11615.jpg",licenceType:"CC BY 3.0",editedByType:null,isbn:"978-1-80356-213-1",printIsbn:"978-1-80356-212-4",pdfIsbn:"978-1-80356-214-8",isAvailableForWebshopOrdering:!0,editors:[{id:"247727",title:"Prof.",name:"Abdelhadi",middleName:null,surname:"Makan",slug:"abdelhadi-makan",fullName:"Abdelhadi Makan"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:null,sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Formation of protective layers in the digestive mucosa",level:"1"},{id:"sec_3",title:"3. Antioxidant status",level:"1"},{id:"sec_4",title:"4. Immune response and inflammation",level:"1"},{id:"sec_5",title:"5. Digestive microbiota",level:"1"},{id:"sec_5_2",title:"5.1 Antiparasitic effects",level:"2"},{id:"sec_6_2",title:"5.2 Antifungal effects",level:"2"},{id:"sec_8",title:"6. Metabolism of minerals, proteins, and lipids",level:"1"},{id:"sec_8_2",title:"6.1 Minerals",level:"2"},{id:"sec_9_2",title:"6.2 Proteins",level:"2"},{id:"sec_10_2",title:"6.3 Ammonia emissions",level:"2"},{id:"sec_11_2",title:"6.4 Lipids",level:"2"},{id:"sec_13",title:"7. Productive response in animals supplemented with humic substances",level:"1"},{id:"sec_13_2",title:"7.1 Poultry",level:"2"},{id:"sec_14_2",title:"7.2 Pigs",level:"2"},{id:"sec_15_2",title:"7.3 Ruminants",level:"2"},{id:"sec_16_2",title:"7.4 Rabbits",level:"2"},{id:"sec_18",title:"8. Conclusions",level:"1"},{id:"sec_19",title:"Acknowledgments",level:"1"},{id:"sec_22",title:"Conflict of interest",level:"1"}],chapterReferences:[{id:"B1",body:'Swidsinski A, Dörffel Y, Loening-Baucke V, Gille C, Reißhauer A, Göktas O, et al. Impact of humic acids on the colonic microbiome in healthy volunteers. World Journal of Gastroenterology. 2017;23(5):885-890. DOI: 10.3748/wjg.v23.i5.885'},{id:"B2",body:'Goel P, Dhingra M. Humic substances: Prospects for use in agriculture and medicine. In: Makan A, editor. Humic Substances. London: IntechOpen; 2021'},{id:"B3",body:'Yuan S. Application of Fulvic Acid and Its Derivatives in the Fields of Agriculture and Medicine. 1st ed. Sevilla, Spain: IHSS; 1993'},{id:"B4",body:'Priegnitz H. Wasserkur und Badelust. Koehler and Amelang: Leipzig, Germany; 1986'},{id:"B5",body:'Klocking R, Helbig B. Medical aspects and application of humic substances. In: Steinbuchel A, Marchessault RH, editors. 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Asian Australasian Journal of Animal Science. 2005;18:1310-1319'},{id:"B131",body:'Rzasa A, Wincewicz E, Zawadzki W. Humic-fatty acid preparation in growing. Electronic Journal of Polish Agricultural Universities. 2014;17(3):1'},{id:"B132",body:'Shi Y, Parker DB, Cole NA, Auvermann BW, Mehlhorn JE. Surface amendments to minimize ammonia emissions from beef cattle feedlots. Transactions of the American Society of Agricultural Engineers. 2001;44:677-682'},{id:"B133",body:'Herzig I, Kozler J, Písaříková B, Fengl M, Jursa V. Effects of a humine acid-based sorbent on the concentration of ammonia in broiler houses. Archiv fur Geflugelkunde. 2001;65:246-250'},{id:"B134",body:'Terry SA, de Ribeiro G, Gruninger RJ, et al. Effect of humic substances on rumen fermentation, nutrient digestibility, methane emissions, and rumen microbiota in beef heifers. Journal of Animal Science. 2018;96(9):3863-3877. DOI: 10.1093/jas/sky265'},{id:"B135",body:'Samudovská A, Demeterová M. 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The effects of dietary supplementation of L-carnitine and humic substances on performance, egg traits and blood parameters in laying hens. Asian-Australasian Journal Animal Science. 2006;19(10):1478-1483. DOI: 10.5713/ajas.2006.1478'},{id:"B139",body:'Bai HX, Chang QF, Shi BM, Shan AS. Effects of fulvic acid on growth performance and meat quality in growing-finishing pigs. Livestock Science. 2013;158(1-3):118-123. DOI: 10.1016/j.livsci.2013.10.013'},{id:"B140",body:'Chang Q , Lu Z, He M, et al. Effects of dietary supplementation of fulvic acid on lipid metabolism of finishing pigs. Journal of Animal Science. 2014;92(11):4921-4926. DOI: 10.2527/jas.2014-8137'},{id:"B141",body:'Thomassen BPH, Faust RH. The use of a processed humic acid product as a feed supplement in dairy production in the Netherlands. In: The World Grows Organic International Scientific Conference. Basle; 2000. p. 339'},{id:"B142",body:'Livestock R Us, 2003 Lývestock R Us, 2003 Field trials on Dairy Cattle. ENVIROMATE Inc. 8571 Boat Club Road, Fort Worth, Texas 76178. www.livestockrus.com/consignments/viromate/enviromate.htm'},{id:"B143",body:'Tunç MA, Yoruk MA. The Effect of Humate on Rumen Parameters and Blood Values in Sheep. Atatürk Univ Health Sci Ens; 2007'},{id:"B144",body:'Mista D, Rzasa A, Szmańko T, et al. The effect of humic-fatty acid preparation on production parameters and meat quality of growing rabbits. Annal of Animal Science. 2012;12(1):117-126. DOI: 10.2478/v10220-012-0010-x'},{id:"B145",body:'Degirmencioglu T. Using humic acid in diets for dairy goats. Animal Science Paper Reports. 2014;32(1):25-32'},{id:"B146",body:'Gómez-Rosales S, Angeles ML, Hernández-Andrade L. Efecto del nivel de lisina y adición de sustancias húmicas en pollos desafiados con un lipopolisacárido de Escherichia coli en la productividad y resistencia antimicrobiana. In: XXVI Congreso Panamericano de Ciencias Veterinarias. 2021. pp. 1-2'},{id:"B147",body:'Kucukersan S, Kucukersan K, Colpan I, Goncuoglu E, Reisli Z, Yesilbag D. The effects of humic acid on egg production and egg traits of laying hen. Veterinární medicína (Praha). 2005;50(9):406-410. DOI: 10.17221/5640-VETMED'},{id:"B148",body:'Yalçin S, Ergün A, Erol H, Yalçin S, Özsoy B. Use of L-carnitine and humate. Acta Veterinary Hungrarica. 2005;53(3):361-370'},{id:"B149",body:'Kim SW, Hulbert LE, Rachuonyo HA, McGlone JJ. Relative availability of iron in mined humic substances for weanling pigs. Asian-Australasian Journal of Animal Science. 2004;17:1266-1270'},{id:"B150",body:'Zralý Z, Písaříková B. Effect of sodium humate on the content of trace elements in organs of weaned piglets. Acta Veterinaria Brno. 2010;79:73-79. DOI: 10.2754/avb201079010073'}],footnotes:[],contributors:[{corresp:null,contributorFullName:"María de Lourdes Angeles",address:null,affiliation:'
National Center of Disciplinary Research in Animal Physiology and Genetics, National Institute of Research in Forestry, Agriculture and Livestock, Mexico
National Center of Disciplinary Research in Animal Physiology and Genetics, National Institute of Research in Forestry, Agriculture and Livestock, Mexico
Department of Poultry Science, University of Arkansas, USA
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In order to help Authors identify appropriate funding agencies and institutions, we have created a list, based on extensive research on various OA resources (including ROARMAP and SHERPA/JULIET) of organizations that have funds available. Before consulting our list we encourage you to petition your own institution or organization for Open Access funds or check the specifications of your grant with your funder to ascertain if publication costs are included. Where you are in receipt of a grant you should clarify:
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Does your institution already have a budget for covering Open Access publication costs?
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If you are associated with any of the institutions in our list below, you can apply to receive OA publication funds by following the instructions provided in the links. Please consult the Open Access policies or grant Terms and Conditions of any institution with which you are linked to explore ways to cover your publication costs (also accessible by clicking on the link in their title).
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On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. 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Subtle changes that occur over time in periodontal tissues that are below the detection limit of visual examination or periodontal probing can be found and tracked accurately over time using 3D imaging, fluorescence spectroscopy, and optical coherence tomography. During debridement of teeth and dental implants, the effective removal of subgingival microbial biofilms and dental calculus deposits can be enhanced using magnifying loupes and operating microscopes and by novel methods based on the interactions of light with bacterial deposits, such as differential reflectometry and light-induced fluorescence. While such techniques can also be used using initial case assessment, their primary purpose is for checking debridement procedures, since the point when bacterial deposits are no longer present represents an endpoint for treatment. The concept of real-time feedback has been developed, using fluorescence readings to control the removal of deposits. Overall, optical methods can support traditional periodontal diagnosis and improve treatment planning and clinical periodontal care.",book:{id:"7244",slug:"periodontology-and-dental-implantology",title:"Periodontology and Dental Implantology",fullTitle:"Periodontology and Dental Implantology"},signatures:"Fardad Shakibaie and Laurence Walsh",authors:[{id:"179467",title:"Prof.",name:"Laurence",middleName:null,surname:"Walsh",slug:"laurence-walsh",fullName:"Laurence Walsh"},{id:"235443",title:"Dr.",name:"Fardad",middleName:null,surname:"Shakibaie",slug:"fardad-shakibaie",fullName:"Fardad Shakibaie"}]},{id:"24363",title:"Biomechanics of Tooth-Movement: Current Look at Orthodontic Fundamental",slug:"biomechanics-of-tooth-movement-current-look-at-orthodontic-fundamental",totalDownloads:26821,totalCrossrefCites:0,totalDimensionsCites:0,abstract:null,book:{id:"277",slug:"principles-in-contemporary-orthodontics",title:"Principles in Contemporary Orthodontics",fullTitle:"Principles in Contemporary Orthodontics"},signatures:"Joanna Antoszewska and Nazan Küçükkeles",authors:[{id:"50158",title:"Prof.",name:"Joanna",middleName:null,surname:"Antoszewska",slug:"joanna-antoszewska",fullName:"Joanna Antoszewska"}]},{id:"71271",title:"Flap Techniques in Dentoalveolar Surgery",slug:"flap-techniques-in-dentoalveolar-surgery",totalDownloads:2638,totalCrossrefCites:1,totalDimensionsCites:1,abstract:"Most dentoalveolar procedures involve the reflection of mucosal flaps. This step is crucial for exposure or removal of impacted teeth, implant bed preparation, exposure of the alveolar bone for augmentation, periodontal surgeries, and repair of mucosal soft tissue defects, such as oroantral fistula. Because of the rich vascularity of the oral mucosa, great freedom is allowed for flap design, but it tends to result in carelessness and lack of thoughtful planning, which may lead to uneventful outcomes or/and complications. In this chapter, we review oral anatomy, classification, indications, and complications of common oral flap techniques; common flap designs are illustrated, and their fundamental principles are highlighted. The review has covered various flap designs based on their indications. Yet the common flap’s principles are fundamental for all types of flaps regardless of their application, namely, it should provide wide exposure, clear vision, good access, and assure rich vascularity and good final aesthetic outcome.",book:{id:"9387",slug:"oral-diseases",title:"Oral Diseases",fullTitle:"Oral Diseases"},signatures:"Randa Abdulmoein AlFotawi",authors:[{id:"308701",title:"Dr.",name:"Randa",middleName:"Abdulmoein",surname:"Alfotawi",slug:"randa-alfotawi",fullName:"Randa Alfotawi"}]},{id:"65088",title:"Evaluation and Management of Mandibular Fracture",slug:"evaluation-and-management-of-mandibular-fracture",totalDownloads:2911,totalCrossrefCites:1,totalDimensionsCites:1,abstract:"The mandibular bone is an important component of the facial bone, which has a unique role in digestive system, speech, and facial esthetics. For these important functions of mandibular bone, it is vital that surgeons should not only treat function but also consider the esthetics together. Mandibular fractures are among the most common traumatic injuries of the maxillofacial region. Even though treatment modalities are well established and being practiced for a long time, untreated and postoperative complications still decrease the patient’s quality of life. This chapter aims to describe the cause, clinical presentations, diagnoses, and current treatment methods on the basis of resent literature.",book:{id:"7572",slug:"trauma-in-dentistry",title:"Trauma in Dentistry",fullTitle:"Trauma in Dentistry"},signatures:"Guhan Dergin, Yusuf Emes and Buket Aybar",authors:[{id:"178412",title:"Associate Prof.",name:"Guhan",middleName:null,surname:"Dergin",slug:"guhan-dergin",fullName:"Guhan Dergin"},{id:"178414",title:"Prof.",name:"Yusuf",middleName:null,surname:"Emes",slug:"yusuf-emes",fullName:"Yusuf Emes"},{id:"202198",title:"Dr.",name:"Buket",middleName:null,surname:"Aybar",slug:"buket-aybar",fullName:"Buket Aybar"}]},{id:"56461",title:"Permanent Maxillary and Mandibular Incisors",slug:"permanent-maxillary-and-mandibular-incisors",totalDownloads:2732,totalCrossrefCites:1,totalDimensionsCites:1,abstract:"The permanent incisors are the front teeth that erupt between 6 and 8 years of age. They are eight in number, four upper and four lower, two centrals and two laterals. They have sharp biting surfaces designed for shearing and cutting of food materials into small chewable pieces. They are the teeth most visible to the others during eating, smiling and talking, and thus, they have high aesthetic value for the individuals. The unique characteristics, arch position, function, development and chronological age of each tooth will be highlighted. In addition, the different aspects with their geometric outlines, outlines and surface anatomy of these teeth will be described. A brief explanation about the pulp cavity, tooth socket and normal occlusion for each tooth will be included.",book:{id:"5814",slug:"dental-anatomy",title:"Dental Anatomy",fullTitle:"Dental Anatomy"},signatures:"Mohammed E. Grawish, Lamyaa M. Grawish and Hala M. 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The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. This Biochemistry Series will address the current research on biomolecules and the emerging trends with great promise.",coverUrl:"https://cdn.intechopen.com/series/covers/11.jpg",latestPublicationDate:"August 17th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:33,editor:{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",slug:"miroslav-blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:4,paginationItems:[{id:"14",title:"Cell and Molecular Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",isOpenForSubmission:!0,annualVolume:11410,editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",slug:"rosa-maria-martinez-espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",biography:"Rosa María Martínez-Espinosa is a Full Professor of Biochemistry and Molecular Biology at the University of Alicante, Spain, and has been the vice president of International Relations and Development Cooperation at this university since 2010. She created the research group in applied biochemistry in 2017 (https://web.ua.es/en/appbiochem/), and from 1999 to the present has made more than 200 contributions to Spanish and international conferences. Furthermore, she has around seventy-five scientific publications in indexed journals, eighty book chapters, and one patent to her credit. Her research work focuses on microbial metabolism (particularly on extremophile microorganisms), purification and characterization of enzymes with potential industrial and biotechnological applications, protocol optimization for genetically manipulating microorganisms, gene regulation characterization, carotenoid (pigment) production, and design and development of contaminated water and soil bioremediation processes by means of microorganisms. This research has received competitive public grants from the European Commission, the Spanish Ministry of Economy and Competitiveness, the Valencia Region Government, and the University of Alicante.",institutionString:"University of Alicante",institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"15",title:"Chemical Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",isOpenForSubmission:!0,annualVolume:11411,editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",slug:"sukru-beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",biography:"Dr. Şükrü Beydemir obtained a BSc in Chemistry in 1995 from Yüzüncü Yıl University, MSc in Biochemistry in 1998, and PhD in Biochemistry in 2002 from Atatürk University, Turkey. He performed post-doctoral studies at Max-Planck Institute, Germany, and University of Florence, Italy in addition to making several scientific visits abroad. He currently works as a Full Professor of Biochemistry in the Faculty of Pharmacy, Anadolu University, Turkey. Dr. Beydemir has published over a hundred scientific papers spanning protein biochemistry, enzymology and medicinal chemistry, reviews, book chapters and presented several conferences to scientists worldwide. He has received numerous publication awards from various international scientific councils. He serves in the Editorial Board of several international journals. Dr. Beydemir is also Rector of Bilecik Şeyh Edebali University, Turkey.",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",slug:"deniz-ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",biography:"Dr. Deniz Ekinci obtained a BSc in Chemistry in 2004, MSc in Biochemistry in 2006, and PhD in Biochemistry in 2009 from Atatürk University, Turkey. He studied at Stetson University, USA, in 2007-2008 and at the Max Planck Institute of Molecular Cell Biology and Genetics, Germany, in 2009-2010. Dr. Ekinci currently works as a Full Professor of Biochemistry in the Faculty of Agriculture and is the Head of the Enzyme and Microbial Biotechnology Division, Ondokuz Mayıs University, Turkey. He is a member of the Turkish Biochemical Society, American Chemical Society, and German Genetics society. Dr. Ekinci published around ninety scientific papers, reviews and book chapters, and presented several conferences to scientists. He has received numerous publication awards from several scientific councils. Dr. Ekinci serves as the Editor in Chief of four international books and is involved in the Editorial Board of several international journals.",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null},{id:"17",title:"Metabolism",coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",isOpenForSubmission:!0,annualVolume:11413,editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",slug:"yannis-karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",biography:"Yannis Karamanos, born in Greece in 1953, completed his pre-graduate studies at the Université Pierre et Marie Curie, Paris, then his Masters and Doctoral degree at the Université de Lille (1983). He was associate professor at the University of Limoges (1987) before becoming full professor of biochemistry at the Université d’Artois (1996). He worked on the structure-function relationships of glycoconjugates and his main project was the investigations on the biological roles of the de-N-glycosylation enzymes (Endo-N-acetyl-β-D-glucosaminidase and peptide-N4-(N-acetyl-β-glucosaminyl) asparagine amidase). From 2002 he contributes to the understanding of the Blood-brain barrier functioning using proteomics approaches. He has published more than 70 papers. His teaching areas are energy metabolism and regulation, integration and organ specialization and metabolic adaptation.",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null},{id:"18",title:"Proteomics",coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",isOpenForSubmission:!0,annualVolume:11414,editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",slug:"paolo-iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",biography:"Paolo Iadarola graduated with a degree in Chemistry from the University of Pavia (Italy) in July 1972. He then worked as an Assistant Professor at the Faculty of Science of the same University until 1984. In 1985, Prof. Iadarola became Associate Professor at the Department of Biology and Biotechnologies of the University of Pavia and retired in October 2017. Since then, he has been working as an Adjunct Professor in the same Department at the University of Pavia. His research activity during the first years was primarily focused on the purification and structural characterization of enzymes from animal and plant sources. During this period, Prof. Iadarola familiarized himself with the conventional techniques used in column chromatography, spectrophotometry, manual Edman degradation, and electrophoresis). Since 1995, he has been working on: i) the determination in biological fluids (serum, urine, bronchoalveolar lavage, sputum) of proteolytic activities involved in the degradation processes of connective tissue matrix, and ii) on the identification of biological markers of lung diseases. In this context, he has developed and validated new methodologies (e.g., Capillary Electrophoresis coupled to Laser-Induced Fluorescence, CE-LIF) whose application enabled him to determine both the amounts of biochemical markers (Desmosines) in urine/serum of patients affected by Chronic Obstructive Pulmonary Disease (COPD) and the activity of proteolytic enzymes (Human Neutrophil Elastase, Cathepsin G, Pseudomonas aeruginosa elastase) in sputa of these patients. More recently, Prof. Iadarola was involved in developing techniques such as two-dimensional electrophoresis coupled to liquid chromatography/mass spectrometry (2DE-LC/MS) for the proteomic analysis of biological fluids aimed at the identification of potential biomarkers of different lung diseases. He is the author of about 150 publications (According to Scopus: H-Index: 23; Total citations: 1568- According to WOS: H-Index: 20; Total Citations: 1296) of peer-reviewed international journals. He is a Consultant Reviewer for several journals, including the Journal of Chromatography A, Journal of Chromatography B, Plos ONE, Proteomes, International Journal of Molecular Science, Biotech, Electrophoresis, and others. He is also Associate Editor of Biotech.",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",slug:"simona-viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",biography:"Simona Viglio is an Associate Professor of Biochemistry at the Department of Molecular Medicine at the University of Pavia. She has been working since 1995 on the determination of proteolytic enzymes involved in the degradation process of connective tissue matrix and on the identification of biological markers of lung diseases. She gained considerable experience in developing and validating new methodologies whose applications allowed her to determine both the amount of biomarkers (Desmosine and Isodesmosine) in the urine of patients affected by COPD, and the activity of proteolytic enzymes (HNE, Cathepsin G, Pseudomonas aeruginosa elastase) in the sputa of these patients. Simona Viglio was also involved in research dealing with the supplementation of amino acids in patients with brain injury and chronic heart failure. She is presently engaged in the development of 2-DE and LC-MS techniques for the study of proteomics in biological fluids. The aim of this research is the identification of potential biomarkers of lung diseases. She is an author of about 90 publications (According to Scopus: H-Index: 23; According to WOS: H-Index: 20) on peer-reviewed journals, a member of the “Società Italiana di Biochimica e Biologia Molecolare,“ and a Consultant Reviewer for International Journal of Molecular Science, Journal of Chromatography A, COPD, Plos ONE and Nutritional Neuroscience.",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null}]},overviewPageOFChapters:{paginationCount:6,paginationItems:[{id:"82526",title:"Deep Multiagent Reinforcement Learning Methods Addressing the Scalability Challenge",doi:"10.5772/intechopen.105627",signatures:"Theocharis Kravaris and George A. Vouros",slug:"deep-multiagent-reinforcement-learning-methods-addressing-the-scalability-challenge",totalDownloads:19,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Multi-Agent Technologies and Machine Learning",coverURL:"https://cdn.intechopen.com/books/images_new/11445.jpg",subseries:{id:"27",title:"Multi-Agent Systems"}}},{id:"82196",title:"Multi-Features Assisted Age Invariant Face Recognition and Retrieval Using CNN with Scale Invariant Heat Kernel Signature",doi:"10.5772/intechopen.104944",signatures:"Kamarajugadda Kishore Kumar and Movva Pavani",slug:"multi-features-assisted-age-invariant-face-recognition-and-retrieval-using-cnn-with-scale-invariant-",totalDownloads:14,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Pattern Recognition - New Insights",coverURL:"https://cdn.intechopen.com/books/images_new/11442.jpg",subseries:{id:"26",title:"Machine Learning and Data Mining"}}},{id:"82063",title:"Evaluating Similarities and Differences between Machine Learning and Traditional Statistical Modeling in Healthcare Analytics",doi:"10.5772/intechopen.105116",signatures:"Michele Bennett, Ewa J. Kleczyk, Karin Hayes and Rajesh Mehta",slug:"evaluating-similarities-and-differences-between-machine-learning-and-traditional-statistical-modelin",totalDownloads:7,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Machine Learning and Data Mining - Annual Volume 2022",coverURL:"https://cdn.intechopen.com/books/images_new/11422.jpg",subseries:{id:"26",title:"Machine Learning and Data Mining"}}},{id:"81791",title:"Self-Supervised Contrastive Representation Learning in Computer Vision",doi:"10.5772/intechopen.104785",signatures:"Yalin Bastanlar and Semih Orhan",slug:"self-supervised-contrastive-representation-learning-in-computer-vision",totalDownloads:61,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Pattern Recognition - New Insights",coverURL:"https://cdn.intechopen.com/books/images_new/11442.jpg",subseries:{id:"26",title:"Machine Learning and Data Mining"}}}]},overviewPagePublishedBooks:{paginationCount:11,paginationItems:[{type:"book",id:"7723",title:"Artificial Intelligence",subtitle:"Applications in Medicine and Biology",coverURL:"https://cdn.intechopen.com/books/images_new/7723.jpg",slug:"artificial-intelligence-applications-in-medicine-and-biology",publishedDate:"July 31st 2019",editedByType:"Edited by",bookSignature:"Marco Antonio Aceves-Fernandez",hash:"a3852659e727f95c98c740ed98146011",volumeInSeries:1,fullTitle:"Artificial Intelligence - Applications in Medicine and Biology",editors:[{id:"24555",title:"Dr.",name:"Marco Antonio",middleName:null,surname:"Aceves Fernandez",slug:"marco-antonio-aceves-fernandez",fullName:"Marco Antonio Aceves Fernandez",profilePictureURL:"https://mts.intechopen.com/storage/users/24555/images/system/24555.jpg",biography:"Dr. Marco Antonio Aceves Fernandez obtained his B.Sc. (Eng.) in Telematics from the Universidad de Colima, Mexico. He obtained both his M.Sc. and Ph.D. from the University of Liverpool, England, in the field of Intelligent Systems. He is a full professor at the Universidad Autonoma de Queretaro, Mexico, and a member of the National System of Researchers (SNI) since 2009. Dr. Aceves Fernandez has published more than 80 research papers as well as a number of book chapters and congress papers. He has contributed in more than 20 funded research projects, both academic and industrial, in the area of artificial intelligence, ranging from environmental, biomedical, automotive, aviation, consumer, and robotics to other applications. He is also a honorary president at the National Association of Embedded Systems (AMESE), a senior member of the IEEE, and a board member of many institutions. His research interests include intelligent and embedded systems.",institutionString:"Universidad Autonoma de Queretaro",institution:{name:"Autonomous University of Queretaro",institutionURL:null,country:{name:"Mexico"}}}]},{type:"book",id:"7726",title:"Swarm Intelligence",subtitle:"Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/7726.jpg",slug:"swarm-intelligence-recent-advances-new-perspectives-and-applications",publishedDate:"December 4th 2019",editedByType:"Edited by",bookSignature:"Javier Del Ser, Esther Villar and Eneko Osaba",hash:"e7ea7e74ce7a7a8e5359629e07c68d31",volumeInSeries:2,fullTitle:"Swarm Intelligence - Recent Advances, New Perspectives and Applications",editors:[{id:"49813",title:"Dr.",name:"Javier",middleName:null,surname:"Del Ser",slug:"javier-del-ser",fullName:"Javier Del Ser",profilePictureURL:"https://mts.intechopen.com/storage/users/49813/images/system/49813.png",biography:"Prof. Dr. Javier Del Ser received his first PhD in Telecommunication Engineering (Cum Laude) from the University of Navarra, Spain, in 2006, and a second PhD in Computational Intelligence (Summa Cum Laude) from the University of Alcala, Spain, in 2013. He is currently a principal researcher in data analytics and optimisation at TECNALIA (Spain), a visiting fellow at the Basque Center for Applied Mathematics (BCAM) and a part-time lecturer at the University of the Basque Country (UPV/EHU). His research interests gravitate on the use of descriptive, prescriptive and predictive algorithms for data mining and optimization in a diverse range of application fields such as Energy, Transport, Telecommunications, Health and Industry, among others. In these fields he has published more than 240 articles, co-supervised 8 Ph.D. theses, edited 6 books, coauthored 7 patents and participated/led more than 40 research projects. He is a Senior Member of the IEEE, and a recipient of the Biscay Talent prize for his academic career.",institutionString:"Tecnalia Research & Innovation",institution:{name:"Tecnalia",institutionURL:null,country:{name:"Spain"}}}]},{type:"book",id:"7656",title:"Fuzzy Logic",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7656.jpg",slug:"fuzzy-logic",publishedDate:"February 5th 2020",editedByType:"Edited by",bookSignature:"Constantin Volosencu",hash:"54f092d4ffe0abf5e4172a80025019bc",volumeInSeries:3,fullTitle:"Fuzzy Logic",editors:[{id:"1063",title:"Prof.",name:"Constantin",middleName:null,surname:"Volosencu",slug:"constantin-volosencu",fullName:"Constantin Volosencu",profilePictureURL:"https://mts.intechopen.com/storage/users/1063/images/system/1063.png",biography:"Prof. Dr. Constantin Voloşencu graduated as an engineer from\nPolitehnica University of Timișoara, Romania, where he also\nobtained a doctorate degree. He is currently a full professor in\nthe Department of Automation and Applied Informatics at the\nsame university. Dr. Voloşencu is the author of ten books, seven\nbook chapters, and more than 160 papers published in journals\nand conference proceedings. He has also edited twelve books and\nhas twenty-seven patents to his name. He is a manager of research grants, editor in\nchief and member of international journal editorial boards, a former plenary speaker, a member of scientific committees, and chair at international conferences. His\nresearch is in the fields of control systems, control of electric drives, fuzzy control\nsystems, neural network applications, fault detection and diagnosis, sensor network\napplications, monitoring of distributed parameter systems, and power ultrasound\napplications. He has developed automation equipment for machine tools, spooling\nmachines, high-power ultrasound processes, and more.",institutionString:'"Politechnica" University Timişoara',institution:null}]},{type:"book",id:"9963",title:"Advances and Applications in Deep Learning",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9963.jpg",slug:"advances-and-applications-in-deep-learning",publishedDate:"December 9th 2020",editedByType:"Edited by",bookSignature:"Marco Antonio Aceves-Fernandez",hash:"0d51ba46f22e55cb89140f60d86a071e",volumeInSeries:4,fullTitle:"Advances and Applications in Deep Learning",editors:[{id:"24555",title:"Dr.",name:"Marco Antonio",middleName:null,surname:"Aceves Fernandez",slug:"marco-antonio-aceves-fernandez",fullName:"Marco Antonio Aceves Fernandez",profilePictureURL:"https://mts.intechopen.com/storage/users/24555/images/system/24555.jpg",biography:"Dr. Marco Antonio Aceves Fernandez obtained his B.Sc. 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A well-trained biotechnologist with diverse experience on the bench across different research themes ranging from asthma to cancer and other infectious diseases. An individual with a strong commitment and innovative mindset. Have the ability to work on diverse projects such as regenerative and molecular medicine with an overall mindset of improving healthcare.",institutionString:"DY Patil Deemed to Be University",institution:null},{id:"319365",title:"Assistant Prof.",name:"Manash K.",middleName:null,surname:"Paul",slug:"manash-k.-paul",fullName:"Manash K. Paul",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/319365/images/system/319365.png",biography:"Manash K. Paul is a scientist and Principal Investigator at the University of California Los Angeles. He has contributed significantly to the fields of stem cell biology, regenerative medicine, and lung cancer. His research focuses on various signaling processes involved in maintaining stem cell homeostasis during the injury-repair process, deciphering the lung stem cell niche, pulmonary disease modeling, immuno-oncology, and drug discovery. He is currently investigating the role of extracellular vesicles in premalignant lung cell migration and detecting the metastatic phenotype of lung cancer via artificial intelligence-based analyses of exosomal Raman signatures. Dr. Paul also works on spatial multiplex immunofluorescence-based tissue mapping to understand the immune repertoire in lung cancer. Dr. Paul has published in more than sixty-five peer-reviewed international journals and is highly cited. He is the recipient of many awards, including the UCLA Vice Chancellor’s award and the 2022 AAISCR-R Vijayalaxmi Award for Innovative Cancer Research. He is a senior member of the Institute of Electrical and Electronics Engineers (IEEE) and an editorial board member for several international journals.",institutionString:"University of California Los Angeles",institution:{name:"University of California Los Angeles",country:{name:"United States of America"}}},{id:"349288",title:"Prof.",name:"Soumya",middleName:null,surname:"Basu",slug:"soumya-basu",fullName:"Soumya Basu",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035QxIDQA0/Profile_Picture_2022-04-15T07:47:01.jpg",biography:"Soumya Basu, Ph.D., is currently working as an Associate Professor at Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India. With 16+ years of trans-disciplinary research experience in Drug Design, development, and pre-clinical validation; 20+ research article publications in journals of repute, 9+ years of teaching experience, trained with cross-disciplinary education, Dr. Basu is a life-long learner and always thrives for new challenges.\r\nHer research area is the design and synthesis of small molecule partial agonists of PPAR-γ in lung cancer. She is also using artificial intelligence and deep learning methods to understand the exosomal miRNA’s role in cancer metastasis. Dr. Basu is the recipient of many awards including the Early Career Research Award from the Department of Science and Technology, Govt. of India. She is a reviewer of many journals like Molecular Biology Reports, Frontiers in Oncology, RSC Advances, PLOS ONE, Journal of Biomolecular Structure & Dynamics, Journal of Molecular Graphics and Modelling, etc. She has edited and authored/co-authored 21 journal papers, 3 book chapters, and 15 abstracts. She is a Board of Studies member at her university. She is a life member of 'The Cytometry Society”-in India and 'All India Cell Biology Society”- in India.",institutionString:"Dr. D.Y. Patil Vidyapeeth, Pune",institution:{name:"Dr. D.Y. Patil Vidyapeeth, Pune",country:{name:"India"}}},{id:"76477",title:"Prof.",name:"Mirza",middleName:null,surname:"Hasanuzzaman",slug:"mirza-hasanuzzaman",fullName:"Mirza Hasanuzzaman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/76477/images/system/76477.png",biography:"Dr. Mirza Hasanuzzaman is a Professor of Agronomy at Sher-e-Bangla Agricultural University, Bangladesh. He received his Ph.D. in Plant Stress Physiology and Antioxidant Metabolism from Ehime University, Japan, with a scholarship from the Japanese Government (MEXT). Later, he completed his postdoctoral research at the Center of Molecular Biosciences, University of the Ryukyus, Japan, as a recipient of the Japan Society for the Promotion of Science (JSPS) postdoctoral fellowship. He was also the recipient of the Australian Government Endeavour Research Fellowship for postdoctoral research as an adjunct senior researcher at the University of Tasmania, Australia. Dr. Hasanuzzaman’s current work is focused on the physiological and molecular mechanisms of environmental stress tolerance. Dr. Hasanuzzaman has published more than 150 articles in peer-reviewed journals. He has edited ten books and written more than forty book chapters on important aspects of plant physiology, plant stress tolerance, and crop production. According to Scopus, Dr. Hasanuzzaman’s publications have received more than 10,500 citations with an h-index of 53. He has been named a Highly Cited Researcher by Clarivate. He is an editor and reviewer for more than fifty peer-reviewed international journals and was a recipient of the “Publons Peer Review Award” in 2017, 2018, and 2019. He has been honored by different authorities for his outstanding performance in various fields like research and education, and he has received the World Academy of Science Young Scientist Award (2014) and the University Grants Commission (UGC) Award 2018. He is a fellow of the Bangladesh Academy of Sciences (BAS) and the Royal Society of Biology.",institutionString:"Sher-e-Bangla Agricultural University",institution:{name:"Sher-e-Bangla Agricultural University",country:{name:"Bangladesh"}}},{id:"213308",title:"Associate Prof.",name:"Manuel Víctor",middleName:null,surname:"López-González",slug:"manuel-victor-lopez-gonzalez",fullName:"Manuel Víctor López-González",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/213308/images/10301_n.jpg",biography:null,institutionString:null,institution:{name:"University of Malaga",country:{name:"Spain"}}},{id:"169212",title:"Prof.",name:"Pavol",middleName:null,surname:"Svorc",slug:"pavol-svorc",fullName:"Pavol Svorc",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/169212/images/system/169212.jpg",biography:"Dr. Pavol Švorc is an Associate Professor, Doctor of the Natural Sciences, Philosophe Doctor. In 1982 he became a Doctor of the Natural Sciences from General Biology, Natural Faculty, Šafarik’s University in Košice. In 1995 he received a PhD. – Physiology and Patophysiology, Natural Faculty Šafarik’s University in Košice. In 2005 he became an Associate Professor from Normal and Patological Physiology, Medical Faculty, Šafarik’s University in Košice. From 1982 to 1983 Dr.Švorc worked as an independent specialist in the local museum in Poprad, Slovakia. In 1983 he started working as a lecturer at the Department of Physiology, Šafarik’s University in Kosice, Slovakia. From\r\n2011 until 2014 he was a Head of the Institute of Physiology and Pathophysiology, Medical Faculty, University of Ostrava, Czech Republic. His research interest includes:\r\nChronobiology of cardiovascular system, respiratory system and autonomic nervous system.",institutionString:"Pavol Josef Safarik University",institution:{name:"University of Pavol Jozef Šafárik",country:{name:"Slovakia"}}},{id:"187859",title:"Prof.",name:"Kusal",middleName:"K.",surname:"Das",slug:"kusal-das",fullName:"Kusal Das",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSBDeQAO/Profile_Picture_1623411145568",biography:"Kusal K. Das is a Distinguished Chair Professor of Physiology, Shri B. M. Patil Medical College and Director, Centre for Advanced Medical Research (CAMR), BLDE (Deemed to be University), Vijayapur, Karnataka, India. Dr. Das did his M.S. and Ph.D. in Human Physiology from the University of Calcutta, Kolkata. His area of research is focused on understanding of molecular mechanisms of heavy metal activated low oxygen sensing pathways in vascular pathophysiology. He has invented a new method of estimation of serum vitamin E. His expertise in critical experimental protocols on vascular functions in experimental animals was well documented by his quality of publications. He was a Visiting Professor of Medicine at University of Leeds, United Kingdom (2014-2016) and Tulane University, New Orleans, USA (2017). For his immense contribution in medical research Ministry of Science and Technology, Government of India conferred him 'G.P. Chatterjee Memorial Research Prize-2019” and he is also the recipient of 'Dr.Raja Ramanna State Scientist Award 2015” by Government of Karnataka. He is a Fellow of the Royal Society of Biology (FRSB), London and Honorary Fellow of Karnataka Science and Technology Academy, Department of Science and Technology, Government of Karnataka.",institutionString:"BLDE (Deemed to be University), India",institution:null},{id:"243660",title:"Dr.",name:"Mallanagouda Shivanagouda",middleName:null,surname:"Biradar",slug:"mallanagouda-shivanagouda-biradar",fullName:"Mallanagouda Shivanagouda Biradar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243660/images/system/243660.jpeg",biography:"M. S. Biradar is Vice Chancellor and Professor of Medicine of\nBLDE (Deemed to be University), Vijayapura, Karnataka, India.\nHe obtained his MD with a gold medal in General Medicine and\nhas devoted himself to medical teaching, research, and administrations. He has also immensely contributed to medical research\non vascular medicine, which is reflected by his numerous publications including books and book chapters. Professor Biradar was\nalso Visiting Professor at Tulane University School of Medicine, New Orleans, USA.",institutionString:"BLDE (Deemed to be University)",institution:{name:"BLDE University",country:{name:"India"}}},{id:"289796",title:"Dr.",name:"Swastika",middleName:null,surname:"Das",slug:"swastika-das",fullName:"Swastika Das",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/289796/images/system/289796.jpeg",biography:"Swastika N. Das is Professor of Chemistry at the V. P. Dr. P. G.\nHalakatti College of Engineering and Technology, BLDE (Deemed\nto be University), Vijayapura, Karnataka, India. She obtained an\nMSc, MPhil, and PhD in Chemistry from Sambalpur University,\nOdisha, India. Her areas of research interest are medicinal chemistry, chemical kinetics, and free radical chemistry. She is a member\nof the investigators who invented a new modified method of estimation of serum vitamin E. She has authored numerous publications including book\nchapters and is a mentor of doctoral curriculum at her university.",institutionString:"BLDEA’s V.P.Dr.P.G.Halakatti College of Engineering & Technology",institution:{name:"BLDE University",country:{name:"India"}}},{id:"248459",title:"Dr.",name:"Akikazu",middleName:null,surname:"Takada",slug:"akikazu-takada",fullName:"Akikazu Takada",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248459/images/system/248459.png",biography:"Akikazu Takada was born in Japan, 1935. After graduation from\nKeio University School of Medicine and finishing his post-graduate studies, he worked at Roswell Park Memorial Institute NY,\nUSA. He then took a professorship at Hamamatsu University\nSchool of Medicine. In thrombosis studies, he found the SK\npotentiator that enhances plasminogen activation by streptokinase. He is very much interested in simultaneous measurements\nof fatty acids, amino acids, and tryptophan degradation products. By using fatty\nacid analyses, he indicated that plasma levels of trans-fatty acids of old men were\nfar higher in the US than Japanese men. . He also showed that eicosapentaenoic acid\n(EPA) and docosahexaenoic acid (DHA) levels are higher, and arachidonic acid\nlevels are lower in Japanese than US people. By using simultaneous LC/MS analyses\nof plasma levels of tryptophan metabolites, he recently found that plasma levels of\nserotonin, kynurenine, or 5-HIAA were higher in patients of mono- and bipolar\ndepression, which are significantly different from observations reported before. In\nview of recent reports that plasma tryptophan metabolites are mainly produced by\nmicrobiota. He is now working on the relationships between microbiota and depression or autism.",institutionString:"Hamamatsu University School of Medicine",institution:{name:"Hamamatsu University School of Medicine",country:{name:"Japan"}}},{id:"137240",title:"Prof.",name:"Mohammed",middleName:null,surname:"Khalid",slug:"mohammed-khalid",fullName:"Mohammed Khalid",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/137240/images/system/137240.png",biography:"Mohammed Khalid received his B.S. in Chemistry in July 2000, and his Ph.D. in Physical Chemistry in 2007 from the University of Khartoum, Sudan. In 2009 he joined the Dr. Ron Clarke research group at the School of Chemistry, Faculty of Science, University of Sydney, Australia as a postdoctoral fellow where he worked on the Interaction of ATP with the phosphoenzyme of the Na+, K+-ATPase, and Dual mechanisms of allosteric acceleration of the Na+, K+-ATPase by ATP. He then worked as Assistant Professor at the Department of Chemistry, University of Khartoum, and in 2014 was promoted to Associate Professor ranking. In 2011 he joined the staff of the Chemistry Department at Taif University, Saudi Arabia, where he is currently active as an Assistant Professor. His research interests include:\r\n(1) P-type ATPase Enzyme Kinetics and Mechanisms; (2) Kinetics and Mechanism of Redox Reactions; (3) Autocatalytic reactions; (4) Computational enzyme kinetics; (5) Allosteric acceleration of P-type ATPases by ATP; (6) Exploring of allosteric sites of ATPases and interaction of ATP with ATPases located in the cell membranes.",institutionString:"Taif University",institution:{name:"Taif University",country:{name:"Saudi Arabia"}}},{id:"63810",title:"Prof.",name:"Jorge",middleName:null,surname:"Morales-Montor",slug:"jorge-morales-montor",fullName:"Jorge Morales-Montor",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/63810/images/system/63810.png",biography:"Dr. Jorge Morales-Montor was recognized with the Lola and Igo Flisser PUIS Award for best graduate thesis at the national level in the field of parasitology. He received a fellowship from the Fogarty Foundation to perform postdoctoral research stay at the University of Georgia. He has 153 journal articles to his credit. He has also edited several books and published more than fifty-five book chapters. He is a member of the Mexican Academy of Sciences, Latin American Academy of Sciences, and the National Academy of Medicine. He has received more than thirty-five awards and has supervised numerous bachelor’s, master’s, and Ph.D. students. Dr. Morales-Montor is the past president of the Mexican Society of Parasitology.",institutionString:"National Autonomous University of Mexico",institution:{name:"National Autonomous University of Mexico",country:{name:"Mexico"}}},{id:"217215",title:"Dr.",name:"Palash",middleName:null,surname:"Mandal",slug:"palash-mandal",fullName:"Palash Mandal",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/217215/images/system/217215.jpeg",biography:null,institutionString:"Charusat University",institution:null},{id:"49739",title:"Dr.",name:"Leszek",middleName:null,surname:"Szablewski",slug:"leszek-szablewski",fullName:"Leszek Szablewski",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49739/images/system/49739.jpg",biography:"Leszek Szablewski is a professor of medical sciences. He received his M.S. in the Faculty of Biology from the University of Warsaw and his PhD degree from the Institute of Experimental Biology Polish Academy of Sciences. He habilitated in the Medical University of Warsaw, and he obtained his degree of Professor from the President of Poland. Professor Szablewski is the Head of Chair and Department of General Biology and Parasitology, Medical University of Warsaw. Professor Szablewski has published over 80 peer-reviewed papers in journals such as Journal of Alzheimer’s Disease, Biochim. Biophys. Acta Reviews of Cancer, Biol. Chem., J. Biomed. Sci., and Diabetes/Metabol. Res. Rev, Endocrine. He is the author of two books and four book chapters. He has edited four books, written 15 scripts for students, is the ad hoc reviewer of over 30 peer-reviewed journals, and editorial member of peer-reviewed journals. Prof. Szablewski’s research focuses on cell physiology, genetics, and pathophysiology. He works on the damage caused by lack of glucose homeostasis and changes in the expression and/or function of glucose transporters due to various diseases. He has given lectures, seminars, and exercises for students at the Medical University.",institutionString:"Medical University of Warsaw",institution:{name:"Medical University of Warsaw",country:{name:"Poland"}}},{id:"173123",title:"Dr.",name:"Maitham",middleName:null,surname:"Khajah",slug:"maitham-khajah",fullName:"Maitham Khajah",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/173123/images/system/173123.jpeg",biography:"Dr. Maitham A. Khajah received his degree in Pharmacy from Faculty of Pharmacy, Kuwait University, in 2003 and obtained his PhD degree in December 2009 from the University of Calgary, Canada (Gastrointestinal Science and Immunology). Since January 2010 he has been assistant professor in Kuwait University, Faculty of Pharmacy, Department of Pharmacology and Therapeutics. His research interest are molecular targets for the treatment of inflammatory bowel disease (IBD) and the mechanisms responsible for immune cell chemotaxis. He cosupervised many students for the MSc Molecular Biology Program, College of Graduate Studies, Kuwait University. Ever since joining Kuwait University in 2010, he got various grants as PI and Co-I. He was awarded the Best Young Researcher Award by Kuwait University, Research Sector, for the Year 2013–2014. He was a member in the organizing committee for three conferences organized by Kuwait University, Faculty of Pharmacy, as cochair and a member in the scientific committee (the 3rd, 4th, and 5th Kuwait International Pharmacy Conference).",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"195136",title:"Dr.",name:"Aya",middleName:null,surname:"Adel",slug:"aya-adel",fullName:"Aya Adel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/195136/images/system/195136.jpg",biography:"Dr. Adel works as an Assistant Lecturer in the unit of Phoniatrics, Department of Otolaryngology, Ain Shams University in Cairo, Egypt. Dr. Adel is especially interested in joint attention and its impairment in autism spectrum disorder",institutionString:"Ain Shams University",institution:{name:"Ain Shams University",country:{name:"Egypt"}}},{id:"94911",title:"Dr.",name:"Boulenouar",middleName:null,surname:"Mesraoua",slug:"boulenouar-mesraoua",fullName:"Boulenouar Mesraoua",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94911/images/system/94911.png",biography:"Dr Boulenouar Mesraoua is the Associate Professor of Clinical Neurology at Weill Cornell Medical College-Qatar and a Consultant Neurologist at Hamad Medical Corporation at the Neuroscience Department; He graduated as a Medical Doctor from the University of Oran, Algeria; he then moved to Belgium, the City of Liege, for a Residency in Internal Medicine and Neurology at Liege University; after getting the Belgian Board of Neurology (with high marks), he went to the National Hospital for Nervous Diseases, Queen Square, London, United Kingdom for a fellowship in Clinical Neurophysiology, under Pr Willison ; Dr Mesraoua had also further training in Epilepsy and Continuous EEG Monitoring for two years (from 2001-2003) in the Neurophysiology department of Zurich University, Switzerland, under late Pr Hans Gregor Wieser ,an internationally known epileptologist expert. \n\nDr B. Mesraoua is the Director of the Neurology Fellowship Program at the Neurology Section and an active member of the newly created Comprehensive Epilepsy Program at Hamad General Hospital, Doha, Qatar; he is also Assistant Director of the Residency Program at the Qatar Medical School. \nDr B. Mesraoua's main interests are Epilepsy, Multiple Sclerosis, and Clinical Neurology; He is the Chairman and the Organizer of the well known Qatar Epilepsy Symposium, he is running yearly for the past 14 years and which is considered a landmark in the Gulf region; He has also started last year , together with other epileptologists from Qatar, the region and elsewhere, a yearly International Epilepsy School Course, which was attended by many neurologists from the Area.\n\nInternationally, Dr Mesraoua is an active and elected member of the Commission on Eastern Mediterranean Region (EMR ) , a regional branch of the International League Against Epilepsy (ILAE), where he represents the Middle East and North Africa(MENA ) and where he holds the position of chief of the Epilepsy Epidemiology Section; Dr Mesraoua is a member of the American Academy of Neurology, the Europeen Academy of Neurology and the American Epilepsy Society.\n\nDr Mesraoua's main objectives are to encourage frequent gathering of the epileptologists/neurologists from the MENA region and the rest of the world, promote Epilepsy Teaching in the MENA Region, and encourage multicenter studies involving neurologists and epileptologists in the MENA region, particularly epilepsy epidemiological studies. \n\nDr. Mesraoua is the recipient of two research Grants, as the Lead Principal Investigator (750.000 USD and 250.000 USD) from the Qatar National Research Fund (QNRF) and the Hamad Hospital Internal Research Grant (IRGC), on the following topics : “Continuous EEG Monitoring in the ICU “ and on “Alpha-lactoalbumin , proof of concept in the treatment of epilepsy” .Dr Mesraoua is a reviewer for the journal \"seizures\" (Europeen Epilepsy Journal ) as well as dove journals ; Dr Mesraoua is the author and co-author of many peer reviewed publications and four book chapters in the field of Epilepsy and Clinical Neurology",institutionString:"Weill Cornell Medical College in Qatar",institution:{name:"Weill Cornell Medical College in Qatar",country:{name:"Qatar"}}},{id:"282429",title:"Prof.",name:"Covanis",middleName:null,surname:"Athanasios",slug:"covanis-athanasios",fullName:"Covanis Athanasios",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/282429/images/system/282429.jpg",biography:null,institutionString:"Neurology-Neurophysiology Department of the Children Hospital Agia Sophia",institution:null},{id:"190980",title:"Prof.",name:"Marwa",middleName:null,surname:"Mahmoud Saleh",slug:"marwa-mahmoud-saleh",fullName:"Marwa Mahmoud Saleh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/190980/images/system/190980.jpg",biography:"Professor Marwa Mahmoud Saleh is a doctor of medicine and currently works in the unit of Phoniatrics, Department of Otolaryngology, Ain Shams University in Cairo, Egypt. She got her doctoral degree in 1991 and her doctoral thesis was accomplished in the University of Iowa, United States. Her publications covered a multitude of topics as videokymography, cochlear implants, stuttering, and dysphagia. She has lectured Egyptian phonology for many years. Her recent research interest is joint attention in autism.",institutionString:"Ain Shams University",institution:{name:"Ain Shams University",country:{name:"Egypt"}}},{id:"259190",title:"Dr.",name:"Syed Ali Raza",middleName:null,surname:"Naqvi",slug:"syed-ali-raza-naqvi",fullName:"Syed Ali Raza Naqvi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259190/images/system/259190.png",biography:"Dr. Naqvi is a radioanalytical chemist and is working as an associate professor of analytical chemistry in the Department of Chemistry, Government College University, Faisalabad, Pakistan. Advance separation techniques, nuclear analytical techniques and radiopharmaceutical analysis are the main courses that he is teaching to graduate and post-graduate students. In the research area, he is focusing on the development of organic- and biomolecule-based radiopharmaceuticals for diagnosis and therapy of infectious and cancerous diseases. Under the supervision of Dr. Naqvi, three students have completed their Ph.D. degrees and 41 students have completed their MS degrees. He has completed three research projects and is currently working on 2 projects entitled “Radiolabeling of fluoroquinolone derivatives for the diagnosis of deep-seated bacterial infections” and “Radiolabeled minigastrin peptides for diagnosis and therapy of NETs”. He has published about 100 research articles in international reputed journals and 7 book chapters. Pakistan Institute of Nuclear Science & Technology (PINSTECH) Islamabad, Punjab Institute of Nuclear Medicine (PINM), Faisalabad and Institute of Nuclear Medicine and Radiology (INOR) Abbottabad are the main collaborating institutes.",institutionString:"Government College University",institution:{name:"Government College University, Faisalabad",country:{name:"Pakistan"}}},{id:"58390",title:"Dr.",name:"Gyula",middleName:null,surname:"Mozsik",slug:"gyula-mozsik",fullName:"Gyula Mozsik",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/58390/images/system/58390.png",biography:"Gyula Mózsik MD, Ph.D., ScD (med), is an emeritus professor of Medicine at the First Department of Medicine, Univesity of Pécs, Hungary. He was head of this department from 1993 to 2003. His specializations are medicine, gastroenterology, clinical pharmacology, clinical nutrition, and dietetics. His research fields are biochemical pharmacological examinations in the human gastrointestinal (GI) mucosa, mechanisms of retinoids, drugs, capsaicin-sensitive afferent nerves, and innovative pharmacological, pharmaceutical, and nutritional (dietary) research in humans. He has published about 360 peer-reviewed papers, 197 book chapters, 692 abstracts, 19 monographs, and has edited 37 books. He has given about 1120 regular and review lectures. He has organized thirty-eight national and international congresses and symposia. He is the founder of the International Conference on Ulcer Research (ICUR); International Union of Pharmacology, Gastrointestinal Section (IUPHAR-GI); Brain-Gut Society symposiums, and gastrointestinal cytoprotective symposiums. He received the Andre Robert Award from IUPHAR-GI in 2014. Fifteen of his students have been appointed as full professors in Egypt, Cuba, and Hungary.",institutionString:"University of Pécs",institution:{name:"University of Pecs",country:{name:"Hungary"}}},{id:"277367",title:"M.Sc.",name:"Daniel",middleName:"Martin",surname:"Márquez López",slug:"daniel-marquez-lopez",fullName:"Daniel Márquez López",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/277367/images/7909_n.jpg",biography:"Msc Daniel Martin Márquez López has a bachelor degree in Industrial Chemical Engineering, a Master of science degree in the same área and he is a PhD candidate for the Instituto Politécnico Nacional. His Works are realted to the Green chemistry field, biolubricants, biodiesel, transesterification reactions for biodiesel production and the manipulation of oils for therapeutic purposes.",institutionString:null,institution:{name:"Instituto Politécnico Nacional",country:{name:"Mexico"}}},{id:"196544",title:"Prof.",name:"Angel",middleName:null,surname:"Catala",slug:"angel-catala",fullName:"Angel Catala",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/196544/images/system/196544.jpg",biography:"Angel Catalá studied chemistry at Universidad Nacional de La Plata, Argentina, where he received a Ph.D. in Chemistry (Biological Branch) in 1965. From 1964 to 1974, he worked as an Assistant in Biochemistry at the School of Medicine at the same university. From 1974 to 1976, he was a fellow of the National Institutes of Health (NIH) at the University of Connecticut, Health Center, USA. From 1985 to 2004, he served as a Full Professor of Biochemistry at the Universidad Nacional de La Plata. He is a member of the National Research Council (CONICET), Argentina, and the Argentine Society for Biochemistry and Molecular Biology (SAIB). His laboratory has been interested for many years in the lipid peroxidation of biological membranes from various tissues and different species. Dr. Catalá has directed twelve doctoral theses, published more than 100 papers in peer-reviewed journals, several chapters in books, and edited twelve books. He received awards at the 40th International Conference Biochemistry of Lipids 1999 in Dijon, France. He is the winner of the Bimbo Pan-American Nutrition, Food Science and Technology Award 2006 and 2012, South America, Human Nutrition, Professional Category. In 2006, he won the Bernardo Houssay award in pharmacology, in recognition of his meritorious works of research. Dr. Catalá belongs to the editorial board of several journals including Journal of Lipids; International Review of Biophysical Chemistry; Frontiers in Membrane Physiology and Biophysics; World Journal of Experimental Medicine and Biochemistry Research International; World Journal of Biological Chemistry, Diabetes, and the Pancreas; International Journal of Chronic Diseases & Therapy; and International Journal of Nutrition. He is the co-editor of The Open Biology Journal and associate editor for Oxidative Medicine and Cellular Longevity.",institutionString:"Universidad Nacional de La Plata",institution:{name:"National University of La Plata",country:{name:"Argentina"}}},{id:"186585",title:"Dr.",name:"Francisco Javier",middleName:null,surname:"Martin-Romero",slug:"francisco-javier-martin-romero",fullName:"Francisco Javier Martin-Romero",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSB3HQAW/Profile_Picture_1631258137641",biography:"Francisco Javier Martín-Romero (Javier) is a Professor of Biochemistry and Molecular Biology at the University of Extremadura, Spain. He is also a group leader at the Biomarkers Institute of Molecular Pathology. Javier received his Ph.D. in 1998 in Biochemistry and Biophysics. At the National Cancer Institute (National Institute of Health, Bethesda, MD) he worked as a research associate on the molecular biology of selenium and its role in health and disease. After postdoctoral collaborations with Carlos Gutierrez-Merino (University of Extremadura, Spain) and Dario Alessi (University of Dundee, UK), he established his own laboratory in 2008. The interest of Javier's lab is the study of cell signaling with a special focus on Ca2+ signaling, and how Ca2+ transport modulates the cytoskeleton, migration, differentiation, cell death, etc. He is especially interested in the study of Ca2+ channels, and the role of STIM1 in the initiation of pathological events.",institutionString:null,institution:{name:"University of Extremadura",country:{name:"Spain"}}},{id:"198499",title:"Dr.",name:"Daniel",middleName:null,surname:"Glossman-Mitnik",slug:"daniel-glossman-mitnik",fullName:"Daniel Glossman-Mitnik",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/198499/images/system/198499.jpeg",biography:"Dr. Daniel Glossman-Mitnik is currently a Titular Researcher at the Centro de Investigación en Materiales Avanzados (CIMAV), Chihuahua, Mexico, as well as a National Researcher of Level III at the Consejo Nacional de Ciencia y Tecnología, México. His research interest focuses on computational chemistry and molecular modeling of diverse systems of pharmacological, food, and alternative energy interests by resorting to DFT and Conceptual DFT. He has authored a coauthored more than 270 peer-reviewed papers, 32 book chapters, and 4 edited books. He has delivered speeches at many international and domestic conferences. 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