",isbn:"978-1-80355-403-7",printIsbn:"978-1-80355-402-0",pdfIsbn:"978-1-80355-404-4",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!1,isSalesforceBook:!1,isNomenclature:!1,hash:"360fe5dabd12a1f91a5658a5fe3eff66",bookSignature:"Associate Prof. Murat Eyvaz and Dr. Ahmed Albahnasawi",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11934.jpg",keywords:"Hydrogen Sources, Hydrogen Production, Hydrogen Safety, Hydrogen Storage Methods, Environmental Impacts of Hydrogen, Synthetic Fertilizer Production, Aromatization, Hydrocracking, Hydrodesulfurization, Fuel Cells, Gas Turbines, Hydrogen Driven Vehicles",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"February 18th 2022",dateEndSecondStepPublish:"March 18th 2022",dateEndThirdStepPublish:"May 17th 2022",dateEndFourthStepPublish:"August 5th 2022",dateEndFifthStepPublish:"October 4th 2022",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"2 months",secondStepPassed:!0,areRegistrationsClosed:!0,currentStepOfPublishingProcess:4,editedByType:null,kuFlag:!1,biosketch:"Dr. Eyvaz is a pioneering researcher in environmental sciences and engineering, who has co-authored numerous journal articles and conference papers and has four patents on wastewater treatment systems.",coeditorOneBiosketch:"Dr. Albahnasawi is a pioneering researcher in environmental sciences and engineering, who has co-authored numerous journal articles and conference papers on water and wastewater treatment and waste remediation.",coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"170083",title:"Associate Prof.",name:"Murat",middleName:null,surname:"Eyvaz",slug:"murat-eyvaz",fullName:"Murat Eyvaz",profilePictureURL:"https://mts.intechopen.com/storage/users/170083/images/system/170083.png",biography:"Dr. Murat Eyvaz is an associate professor in the Environmental Engineering Department, Gebze Technical University, Turkey. His research interests include applications in water and wastewater treatment facilities, electrochemical treatment processes, filtration systems at the lab and pilot-scale, membrane processes (forward osmosis, reverse osmosis, membrane bioreactors), membrane manufacturing methods (polymeric membranes, nanofiber membranes, electrospinning), spectrophotometric analyses (UV, atomic absorption spectrophotometry), chromatographic analyses (gas chromatography, high-pressure liquid chromatography). He has co-authored many journal articles and conference papers and has taken part in many national projects. He serves as an editor and reviewer for many indexed journals. 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Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"52541",title:"Cattanneo-Christov Heat Flux Model Study for Water-Based CNT Suspended Nanofluid Past a Stretching Surface",doi:"10.5772/65628",slug:"cattanneo-christov-heat-flux-model-study-for-water-based-cnt-suspended-nanofluid-past-a-stretching-s",body:'\n
\n
1. Introduction
\n
From recent few decades, heat transfer enhancement of the nanofluid has turned out to be a topic of main interest for the researchers and scientists. The word “nanofluid” was derived by Choi [1]. He defines a liquid suspension comprising ultrafine particles whose diameter is less than 50 nm. Xuan and Roetzel [2] investigated the mechanism of heat transfer enhancement of the nanofluid. According to them, the nanofluid is a solid-liquid mixture in which metallic or nonmetallic nanoparticles are suspended. The suspended ultrafine particles change transport properties and heat transfer performance of the nanofluid, which exhibits a great potential in enhancing heat transfer. They found that the reduced Nusselt number is a decreasing function of each nanofluid parameters. Khanafer et al. [3] discussed buoyancy-driven heat transfer enhancement in a two-dimensional enclosure utilizing nanofluids. The natural convective boundary-layer flow of a nanofluid over a vertical plate is studied analytically by Kuznetsov and Nield [4]. Boundary layer laminar nanofluid flow over the stretching flat surface has been investigated numerically by Khan and Pop [5]. They show that the reduced Nusselt number is a decreasing function of each dimensionless number, while the reduced Sherwood number is an increasing function of higher Prandtl number. Ebaid and his co-authors [6–10] present boundary-layer flow of a nanofluid past a stretching sheet with different flow geometries and with different conditions. Wang [11] discussed free convection on a vertical stretching surface. Scaling group transformation for MHD(Magneto hydrodynamic) boundary-layer flow of a nanofluid past a vertical stretching surface in the presence of suction/injection was discussed by Kandasamy et al. [12].
\n
Fourier [13] was the first who discussed the heat transfer phenomenon in 1822. The equation presented by him was parabolic in nature and has draw back that in initial disturbance is felt instantly throughout the whole medium. Cattaneo [14] modifies the “Fourier law of heat conduction in which he added the thermal relaxation term. The addition of thermal relaxation time causes heat transportation in the form of thermal waves with finite speed.” Christov [15] in this contest discussed Oldroyd upper-convected derivative as an alternative of time plagiaristic to complete the material-in variant formulation. This model is known as Cattaneo-Christov heat flux model. Tibullo et al. [16] described the uniqueness of Cattaneo-Christov heat flux model for incompressible fluids. Mustafa [17] presented the Cattaneo-Christov heat flux model for Maxwell fluid over a stretching sheet. According to him, velocity is inversely proportional to the viscoelastic fluid parameter. Further, fluid temperature has inverse relationship with the relaxation time for heat flux and with the Prandtl number. Very recently, Salahuddin et al. [18] discussed MHD flow of Cattanneo-Christov heat flux model for Williamson fluid over a stretching sheet with variable thickness. They solved nonlinear problem numerically by using implicit finite difference scheme known as Keller box method. They observed that large values of wall thickness parameter and Weissenberg number are suitable for reduction in velocity profile. For further details, see Refs. [11, 12, 19–32].
\n
The aim of this chapter is to discuss the magnetic field effects on the flow of Cattanneo-Christov heat flux model for water-based CNT suspended nanofluid over a stretching sheet. Because according to the authors, knowledge idea of Cattanneo-Christov heat flux model for water-based CNT suspended nanofluid is not explored so far for stretching sheet. The flow equations are modeled for the first time in the literature transformed into ordinary differential equations using similarity transformations. The numerical solutions are computed using shooting technique and compared with the literature for the special case of pure fluid flow and found to be in good agreement. Graphical results are presented to illustrate the effects of various fluid flow parameters on velocity, heat transfer, Nusselt number, Sherwood number, and skin friction coefficient for different types of nanoparticles.
\n
\n
\n
2. Formatting mathematical model
\n
We discuss the two-dimensional nanofluid flow over a stretching sheet with water as based fluids surrounding single- and multi-wall CNTs. The flow is supposed to be laminar, steady, and incompressible. The base fluid and the CNTs are usual to be in updraft stability. Sheet is whispered to be stretched with the dissimilar velocity Uw, Vw along the x-axis and y-axis, correspondingly. We have taken the invariable ambient temperature T∞. Supplementary new heat model named as Cattanneo-Christov heat flux model is considered to analyze heat transfer phenomena. The x-axis is taken along the sheet, and y-axis is chosen normal to it. Magnetic field of strength B0 is applied normal to the sheet (as shown in Figure 1).
\n
Figure 1.
Physical model for the magnetohydrodynamic nanofluid stretching sheet problem.
\n
With the above analysis, the boundary layer equations for the proposed model, i.e., continuity, momentum, and energy equations, can be written as follows:
where u and v are the velocity components along x and y directions, respectively, T is the temperature of the fluid, B0 is the magnitude of magnetic field, and q is the heat flux. Equation (3) is the Cattaneo-Christov flux model and has the following form:
Further, ρnf is the effective density, μnf is the effective dynamic viscosity, (ρcp)nf is the heat capacitance, αnf is the effective thermal diffusibility, and knf is the effective thermal conductivity of the nanofluid, which are defined as follows:
where μf is the viscosity of base fluid, φ is the nanoparticles fraction, (ρCp)f is the effective heat capacity of a fluid, (ρCp)CNT is the effective heat capacity of a carbon nanotubes, kf and kCNT are the thermal conductivities of the base fluid and carbon nanotubes, respectively, ρf and ρCNT are the thermal conductivities of the base fluid and carbon nanotubes, respectively.
where \n\nPr\n=\n\n\n\n\nμ\n\nc\np\n\n\n\nf\n\n\nk\nf\n\n\n\n is the Prandtl number, γ = aλ2 is the non-dimensional thermal relaxation time, and \n\nβ\n=\nN\n\n\na\n\nν\nf\n\n\n\n\n is the slip parameter.
\n
The quantity of practical interest, in this study, is the skin friction coefficient cf and Nusselt number Nux, which is defined as follows:
The nonlinear ordinary differential equations (9)–(10) subject to the boundary conditions (11) have been solved numerically using an efficient Runge-Kutta fourth-order method along with shooting technique. The asymptotic boundary conditions given by Eq. (11) were replaced by using a value of 15 for the similarity variable ηmax. The choice of ηmax = 15 and the step size Δη = 0.001 ensured that all numerical solutions approached the asymptotic values correctly. For validating of the proposed scheme, a comparison for the Nusselt number with the literature [4, 8, 9] has been shown in Table 2 for both active and passive control of φ in the special case when. Therefore, we are confident that the applied numerical scheme is very accurate.
\n
\n
\n
4. Results and discussion
\n
In this section, the graphical explanation of the numerical results for velocity, temperature, skin friction coefficients, Nusselt number, and stream lines is expressed with respect to certain changes in the physical parameters through illustrations (Figures 2–7). A comparative study for pure water, SWCNT and MWCNT, is also depicted through Tables 1–5.
\n
(Figure 2a and b) represents the changes in the fluid velocity profiles with respect to different values of solid nanoparticle volume fraction. Figure 2(a) shows the variation in solid volume fraction of nanoparticles with respect to Hartmann number M. As Hartmann number is the ratio of electromagnetic forces to the viscous forces. It is observed that when Hartmann number increases, electromagnetic forces will be dominant to the viscous forces that give declines in the velocity field (see Figure 2(a)). Figure 2(b) shows the variation in solid nanoparticle volume fraction with slip parameter β on velocity profile. It is analyzed that with an increase in slip parameter, velocity profile decreases. Further with an increase in solid nanoparticle volume fraction, velocity profile increases, and boundary layer thickness also increases with the increase in Hartmann number M, slip parameter, and solid nanoparticle volume fraction.
\n
Figure 2.
Velocity profile for different values of solid nanoparticle volume fraction. (a) Shows the variation with Hartmann number M. (b) Shows the variation with slip parameter β.
\n
Temperature profile for different values of solid nanoparticle volume fraction with the variation in thermal relaxation time γ, Hartmann number M, and slip parameter β is presented in Figure 3(a–c). Temperature profile decreases with the rise in thermal relaxation time, but thermal boundary layer increases with an increase in thermal relaxation time (see Figure 3(a)). Figure 3(b) depicts that with an increase in electromagnetic forces as compared to the viscous forces, temperature profile and thermal boundary layer increase rapidly. Temperature profile and thermal boundary layer also increase rapidly with the rise in slip parameter (see Figure 3(c)). Moreover, temperature profile and thermal boundary layer increase with an increase in solid nanoparticle volume fraction.
\n
Figure 3.
Temperature profile for different values of solid nanoparticle volume fraction. (a). Shows the variation with thermal relaxation time γ. (b) Shows the variation with Hartmann number M. (c) Shows the variation with slip parameter β.
\n
Figure 4.
Skin friction coefficient for SWCNT and MWCNT. (a) Shows the variation with slip parameter β. (b) Shows the variation with Hartmann number M.
\n
Figure 5.
Nusselt number for SWCNT and MWCNT. (a) Shows the variation with Hartmann number M. (b) Shows the variation with thermal relaxation time γ. (c) Shows the variation with slip parameter β.
\n
Figure 6(a-c).
Streamlines for different values of Hartmann number M other parameters are β = 0.4, γ = 0.3.
\n
Figure 7(a-c).
Isotherms for different values of thermal relaxation time γ other parameters are M = 2, β = 0.2.
\n
\n
\n
\n
\n
\n\n
\n
Physical properties
\n
Base fluid
\n
Nanoparticles
\n
\n
\n
Water
\n
SWCNT
\n
MWCNT
\n
\n\n\n
\n
\nρ (kg/m3)
\n
997
\n
2600
\n
1600
\n
\n
\n
\ncp (J/kg K)
\n
4179
\n
425
\n
796
\n
\n
\n
\nk (W/m K)
\n
0.613
\n
6600
\n
3000
\n
\n\n
Table 1.
Thermophysical properties of different base fluid and CNTs.
Comparison of results for the Nusselt number for pure fluid (φ = 0) with M = 0 and γ = 0.
\n
\n
\n
\n
\n
\n
\n
\n\n
\n
\nφ\n
\n
Cf
\n
\n
\n
\nM = 0
\n
\nM = 0.5
\n
\n
\n
\nβ = 0
\n
\nβ = 1
\n
\nβ = 0
\n
\nβ = 1
\n
\n\n\n
\n
SWCNT
\n
0.0 0.1 0.2
\n
1 1.22904 1.51940
\n
0.43016 0.54480 0.70245
\n
1.11803 1.35495 1.65690
\n
0.46912 0.58833 0.75286
\n
\n
\n
MWCNT
\n
0.0 0.1 0.2
\n
1 1.17475 1.39935
\n
0.43016 0.53298 0.67377
\n
1.11803 1.30590 1.54755
\n
0.46912 0.57942 0.73047
\n
\n\n
Table 4.
Skin friction coefficient for different values of Hartmann number M and slip parameter β.
\n
\n
\n
\n
\n
\n
\n
\n
\n
\n
\n
\n\n
\n
\nφ\n
\n
Nusselt number
\n
\n
\n
\nγ = 0
\n
\nγ = 0
\n
\nγ = 0.1
\n
\nγ = 0.1
\n
\n
\n
\nM = 0
\n
\nM = 0.5
\n
\nM = 1
\n
\nM = 2
\n
\n
\n
\nβ = 0
\n
\nβ = 1
\n
\nβ = 0
\n
\nβ = 1
\n
\nβ = 0
\n
\nβ = 1
\n
\nβ = 0
\n
\nβ = 1
\n
\n\n\n
\n
SWCNT
\n
0.0 0.1 0.2
\n
1.77095 2.66543 3.22397
\n
1.33685 2.03231 2.49289
\n
1.74513 2.60424 3.13585
\n
1.25641 1.89346 2.31928
\n
1.71287 2.48958 2.95535
\n
1.08479 1.58280 1.92489
\n
1.52688 2.07111 2.37985
\n
0.70076 0.92785 1.11466
\n
\n
\n
MWCNT
\n
0.0 0.1
\n
1.77095 2.63339
\n
1.33685 2.02350
\n
1.74513 2.57329
\n
1.25641 1.88386
\n
1.71287 2.46327
\n
1.08479 1.57551
\n
1.52688 2.05686
\n
0.70076 0.92736
\n
\n\n
Table 5.
Nusselt number for different values of Hartmann number M and thermal relaxation time γ.
\n
Variation in skin friction coefficient for SWCNT and MWCNT with slip parameter β and Hartmann number M is presented in Figure 4(a and b). It is seen that with the augment in M, electromagnetic strength is elevated in contrast to thick strength, skin friction coefficient rises for SWCNT as well as for MWCNT, but with the increase in slip parameter, skin friction coefficient decreases for both SWCNT and MWCNT. It is also seen that density and thermal conductivity of SWCNT are greater as compared to the MWCNT; therefore, the skin friction coefficient for SWCNT is greater as compared to the MWCNT.
\n
Nusselt number for SWCNT and MWCNT shows the variation in Hartmann number M, thermal relaxation time γ, and slip parameter β. It is observed that the higher values of thermal relaxation time γ raise the Nusselt number for SWCNT as well as for MWCNT, and it is also analyzed that Nusselt number gives the larger values for SWCNT than MWCNT (see Figure 5(a–c)). Increasing values of Hartmann number M and slip parameter β decrease the Nusselt number for both SWCNT and MWCNT. But due to high density and thermal conductivity of SWCNT, Nusselt number for SWCNT is higher than MWCNT.
\n
Streamlines and Isotherms are presented in Figures 6(a–c) and 7(a–c), respectively. It is analyzed from Figures 6 and 7 that for increasing Hartmann number M and thermal relaxation time γ, streamlines and Isotherms are going close to origin.
\n
\n
\n
5. Conclusions
\n
This chapter discussed the magnetic field effects on the flow of Cattanneo-Christov heat flux model for water-based CNT suspended nanofluid over a stretching sheet. Key points of the performed analysis are as follows:
It is observed that when Hartmann number increases, electromagnetic forces will be dominant to the viscous forces that give declines in the velocity.
It is analyzed that with an increase in slip parameter, velocity profile decreases. Further, with an increase in solid nanoparticle volume fraction, velocity profile increases.
Boundary layer thickness also increases with the increase in Hartmann number M, slip parameter β, and solid nanoparticle volume fraction ϕ.
Temperature profile decreases with the rise in thermal relaxation time, but thermal boundary layer increases with an increase in thermal relaxation time.
It depicts that with an increase in electromagnetic forces as compared to the viscous forces, temperature profile and thermal boundary layer increase rapidly.
Temperature profile and thermal boundary layer also increase rapidly with the rise in slip parameter.
Temperature profile and thermal boundary layer increase with an increase in solid nanoparticle volume fraction.
Skin friction coefficient increases for SWCNT as well for MWCNT, but with the increase in slip parameter, skin friction coefficient decreases for both SWCNT and MWCNT.
It is also seen that thickness and thermal conductivity of SWCNT are better as compared to the MWCNT; consequently, the skin friction coefficient for SWCNT is better as compared to MWCNT.
It is pragmatic that the superior values of thermal relaxation time γ hoist the Nusselt number for SWCNT as well as for MWCNT, and it is also analyzed that Nusselt number gives the well-built principles for SWCNT as evaluated to MWCNT.
It is analyzed from Figures 6 and 7 that for rising Hartmann number M and thermal relaxation time γ, streamlines and isotherms are departing shut to source.
\n\n
\n
\n
Nomenclature
\n
\n
\n
\n\n
\n
\nμf: Viscosity of base fluid
\n
\nq: Heat flux
\n
\n
\n
(ρCp)f: Effective heat capacity of a fluid
\n
\nUw, Vw along the x-axis and y-axis: Thermal Grashof number
\n
\n
\n
(ρCp)CNT: Effective heat capacity of a carbon nanotubes
\n
\ng: Acceleration due to gravity
\n
\n
\n
\nkf: Thermal conductivities of the base fluid
\n
\nλ2: Thermal relaxation time
\n
\n
\n
\nkCNT: Thermal conductivities of the carbon nanotubes
\n
\nBC: Solutal Grashof number
\n
\n
\n
\nB0: Magnitude of magnetic field strength
\n
\nν: Kinematic viscosity of the fluid
\n
\n
\n
\nT: Local fluid temperature
\n
\nPr: Prandtl number
\n
\n
\n
\nT∞: Ambient temperature
\n
\nM: Hartmann number
\n
\n
\n
\nu, v: Velocity components along x and y directions
\n
(ρcp)nf: Heat capacitance
\n
\n
\n
\nP: Pressure
\n
\nρnf: Effective density
\n
\n
\n
\nφ: Nanoparticle volume fraction
\n
\nRex: Local Reynolds number
\n
\n
\n
\nη: Similarity variable (transformed coordinate)
\n
\nαnf: Effective thermal diffusibility
\n
\n
\n
\nNux: Local Nusselt number
\n
\nx, y: Coordinate along and normal to the sheet
\n
\n
\n
(ρc)p: Effective heat capacity of the nanoparticle material
\n
(ρc)f: Heat capacity of the fluid
\n
\n
\n
\nθ: Dimensionless temperature
\n
\nμnf: Effective dynamic viscosity
\n
\n
\n
\nγ: Non-dimensional thermal relaxation time
\n
\nknf: Effective thermal conductivity of the nanofluid
\n
\n\n
\n
\n',keywords:"boundary layer flow, nanofluid, stretching sheet, Cattanneo-Christov heat flux model, numerical solution",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/52541.pdf",chapterXML:"https://mts.intechopen.com/source/xml/52541.xml",downloadPdfUrl:"/chapter/pdf-download/52541",previewPdfUrl:"/chapter/pdf-preview/52541",totalDownloads:1382,totalViews:145,totalCrossrefCites:3,totalDimensionsCites:4,totalAltmetricsMentions:0,impactScore:2,impactScorePercentile:75,impactScoreQuartile:3,hasAltmetrics:0,dateSubmitted:"April 9th 2016",dateReviewed:"September 6th 2016",datePrePublished:null,datePublished:"March 15th 2017",dateFinished:"October 3rd 2016",readingETA:"0",abstract:"This chapter discusses the magnetic field effects on the flow of Cattanneo-Christov heat flux model for water-based CNT suspended nanofluid over a stretching sheet. According to the authors, knowledge idea of Cattanneo-Christov heat flux model for water-based CNT suspended nanofluid is not explored so far for stretching sheet. The flow equations are modeled for the first time in the literature transformed into ordinary differential equations using similarity transformations. The numerical solutions are computed using shooting technique and compared with the literature for the special case of pure fluid flow and found to be in good agreement. Graphical results are presented to illustrate the effects of various fluid flow parameters on velocity, heat transfer, Nusselt number, Sherwood number, and skin friction coefficient for different types of nanoparticles.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/52541",risUrl:"/chapter/ris/52541",book:{id:"5406",slug:"nanofluid-heat-and-mass-transfer-in-engineering-problems"},signatures:"Noreen Sher Akbar, C. M. Khalique and Zafar Hayat Khan",authors:[{id:"94177",title:"Dr.",name:"Chaudry",middleName:"Masood",surname:"Khalique",fullName:"Chaudry Khalique",slug:"chaudry-khalique",email:"Masood.Khalique@nwu.ac.za",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94177/images/688_n.jpg",institution:{name:"North-West University",institutionURL:null,country:{name:"South Africa"}}},{id:"184401",title:"Dr.",name:"Noreen",middleName:null,surname:"Sher Akbar",fullName:"Noreen Sher Akbar",slug:"noreen-sher-akbar",email:"noreensher1@gmail.com",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/184401/images/4760_n.png",institution:null},{id:"188538",title:"Dr.",name:"Z.H",middleName:null,surname:"Khan",fullName:"Z.H Khan",slug:"z.h-khan",email:"zafarhayyatkhan@gmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Formatting mathematical model",level:"1"},{id:"sec_3",title:"3. Numerical scheme",level:"1"},{id:"sec_4",title:"4. Results and discussion",level:"1"},{id:"sec_5",title:"5. Conclusions",level:"1"},{id:"sec_6",title:"",level:"1"}],chapterReferences:[{id:"B1",body:'\nS.U.S. Choi, Enhancing thermal conductivity of fluids with nanoparticles, in: D.A. Siginer, H.P. Wang (Eds.), Developments and Applications of Non-Newtonian Flows, ASME, New York, vol. 66 (1995) 99–105.\n'},{id:"B2",body:'\nY. Xuan, W. Roetzel, Conceptions for heat transfer correlation of nanofluids, Int. J. Heat Mass Transfer. 43 (2000) 3701–3707.\n'},{id:"B3",body:'\nK. Khanafer, K. Vafai, M. Lightstone, Buoyancy-driven heat transfer enhancement in a two-dimensional enclosure utilizing nanofluids, Int. J. Heat Mass Transfer. 46 (2003) 3639–3653.\n'},{id:"B4",body:'\nA.V. Kuznetsov, D.A. Nield, Natural convective boundary-layer flow of a nanofluid past a vertical plate, Int. J. Therm. Sci. 49 (2010) 243–247.\n'},{id:"B5",body:'\nW.A. Khan, I. Pop, Boundary-layer flow of a nanofluid past a stretching sheet, Int. J. Heat Mass Tranfer 53 (2010) 2477–2483.\n'},{id:"B6",body:'\nA. Ebaid, H.A. El-arabawy, Y. Nader, New exact solutions for boundary-layer flow of a nanofluid past a stretching sheet, Int. J. Differential Equ. 2013 (Article ID 865464) 8.\n'},{id:"B7",body:'\nA. Ebaid, E.H. Aly, Exact analytical solution of the peristaltic nanofluids flow in an asymmetric channel with flexible walls: Application to cancer treatment, Comput. Math. Methods Med. 2013 (Article ID 825376) 8.\n'},{id:"B8",body:'\nA. Ebaid and A.M. Wazwaz, On the generalized Exp-function method and its application to boundary layer flow at nano-scale, J. Comput. Theor. Nanosci. 11(1) (2014) 178–184.\n'},{id:"B9",body:'\nA. Ebaid, E.H. Aly, N.Y. Abdelazem, Analytical and numerical investigations for the flow and heat transfer of nanofluids over a stretching sheet with partial slip boundary condition, J. Appl. Math. Inf. Sci. 8(4) (2014) 1639-1645.\n'},{id:"B10",body:'\nA. Ebaid, H.K. Al-Jeaid, H. Al-Aly, Notes on the Perturbation Solutions of the Boundary Layer Flow of Nanofluids Past a Stretching Sheet, Appl. Math. Sci. 7(122) (2013) 6077–6085.\n'},{id:"B11",body:'\nC.Y. Wang, Free convection on a vertical stretching surface, ZAMM J. Appl. Math. Mech. 69(11) (1989) 418–420.\n'},{id:"B12",body:'\nR. Kandasamy, P. Loganathan, P. Puvi Arasu, Scaling group transformation for MHD boundary-layer flow of a nanofluid past a vertical stretching surface in the presence of suction/injection, Nuclear Eng. Design 241(6) (2011) 2053–2059.\n'},{id:"B13",body:'\nB.J. Fourier, Theorie Analytique De Lachaleur, Jacques Gabay, Paris, 1822.\n'},{id:"B14",body:'\nC. Cattaneo, Sulla conduzionedelcalore, AttiSemin. Mat. Fis. Univ. Modena Reggio Emilia 3 (1948) 83–101.\n'},{id:"B15",body:'\nC.I. Christov, On frame indifferent formulation of the Maxwell–Cattaneo model of finite-speed heat conduction, Mech. Res. Commun. 36 (2009) 481–486.\n'},{id:"B16",body:'\nV. Tibullo, V. Zampoli, A uniqueness result for the Cattaneo–Christov heat conduction model applied to incompressible fluids, Mech. Res. Commun. 38 (2011) 77.\n'},{id:"B17",body:'\nM. Mustafa, Cattaneo–Christov heat flux model for rotating flow and heat transfer of upper convected Maxwell fluid, AIP Adv. 5 (2015) 047109.\n'},{id:"B18",body:'\nT. Salahuddin, M.Y. Malik, A. Hussain, S. Bilal, M. Awais, MHD flow of Cattanneo–Christov heat flux model for Williamson fluid over a stretching sheet with variable thickness: Using numerical approach, J. Magnet. Magnet. Mater. 401 (2016) 991–997.\n'},{id:"B19",body:'\nN.S. Akbar, E. Abdelhalim, Z.H. Khan, Numerical analysis of magnetic field effects on Eyring-Powell fluid flow towards a stretching sheet, J. Magnet. Magnet. Mater. 382 (2015) 355–358.\n'},{id:"B20",body:'\nZ.H. Khan, W.A. Khan, R.J. Culham, Estimation of boundary-layer flow of a nanofluid past a stretching sheet: A revised model, J. Hydrodyn. (2015).\n'},{id:"B21",body:'\nN.S. Akbar, Z.H. Khan, S. Nadeem, W.A. Khan, Double-diffusive natural convective boundary-layer flow of a nanofluid over a stretching sheet with magnetic field, Int. J. Numer. Methods Heat Fluid Flow 26(1) (2016) 108–121.\n'},{id:"B22",body:'\nM. Sheikholeslami, D.D. Ganji, M. Gorji-Bandpy, S. Soleimani, Magnetic field effect on nanofluid flow and heat transfer using KKL model, J. Taiwan Inst. Chem. Eng. 45 (2014) 795–807.\n'},{id:"B23",body:'\nH. Togun, G. Ahmadi, T. Abdulrazzaq, A.J. Shkarah, S.N. Kazi, A. Badarudin, M.R. Safaei, Thermal performance of nanofluid in ducts with double forward-facing steps, J. Taiwan Inst. Chem. Eng. 47 (2015) 28–42.\n'},{id:"B24",body:'\nM. Sheikholeslami, R. Ellahi, H.R. Ashorynejad, G. Domairry, Effects of heat transfer in flow of nanofluids over a permeable stretching wall in a porous medium, J. Comput. Theor. Nanosci. 11(2) (2014) 486–496.\n'},{id:"B25",body:'\nM. Sheikholeslami, D.D. Ganji, M.Y. Javed, R. Ellahi, Effect of thermal radiation on magnetohydrodynamics nanofluid flow and heat transfer by means of two phase model, J. Magnet. Magnet. Mater. 374 (2015) 36–43.\n'},{id:"B26",body:'\nM. Sheikholeslami, M. Gorji-Bandpy, Free convection of ferrofluid in a cavity heated from below in the presence of an external magnetic field, Powder Technol. 256 (2014) 490–498.\n'},{id:"B27",body:'\nM. Sheikholeslami, M. Gorji-Bandpy, D.D. Ganji, Lattice Boltzmann method for MHD natural convection heat transfer using nanofluid, Powder Technol. 254 (2014) 82–93.\n'},{id:"B28",body:'\nM. Sheikholeslami, M. Gorji-Bandpy, D.D. Ganji, Numerical investigation of MHD effects on Al2O3-water nanofluid flow and heat transfer in a semi-annulus enclosure using LBM, Energy 60 (2013) 501–510.\n'},{id:"B29",body:'\nM. Sheikholeslami, R. Ellahi, M. Hassan, S. Soleimani, A study of natural convection heat transfer in a nanofluid filled enclosure with elliptic inner cylinder, Int. J. Numer. Methods Heat Fluid Flow 24 (2014) 1906–1927.\n'},{id:"B30",body:'\nM. Sheikholeslami, M. Gorji, M. Bandpy, R. Ellahi, M. Hassan, S. Soleimani, Effects of MHD on Cu-water nanofluid flow and heat transfer by means of CVFEM, J. Magnet. Magnet. Mater. 349 (2014) 188–200.\n'},{id:"B31",body:'\nM. Sheikholeslami, M. Bandpy, M.G.R. Ellahi, R. Zeeshan, A simulation of MHD CuO-water nanofluid flow and convective heat transfer considering Lorentz forces, J. Magnet. Magnet. Mater. 369 (2014) 69–80.\n'},{id:"B32",body:'\nR. Ellahi, M. Gulzar, M. Sheikholeslami, Effects of heat transfer on peristaltic motion of Oldroyd fluid in the presence of inclined magnetic field, J. Magnet. Magnet. Mater. 372 (2014) 97–106.\n'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Noreen Sher Akbar",address:"noreensher1@gmail.com",affiliation:'
DBS&H CEME, National University of Sciences and Technology, Islamabad, Pakistan
'},{corresp:null,contributorFullName:"C. M. Khalique",address:null,affiliation:'
International Institute for Symmetry Analysis and Mathematical Modelling, Department of Mathematical Sciences, South Africa
'},{corresp:null,contributorFullName:"Zafar Hayat Khan",address:null,affiliation:'
Department of Mathematics, University of Malakand, Dir (Lower), Khyber Pakhtunkhwa, Pakistan
'}],corrections:null},book:{id:"5406",type:"book",title:"Nanofluid Heat and Mass Transfer in Engineering Problems",subtitle:null,fullTitle:"Nanofluid Heat and Mass Transfer in Engineering Problems",slug:"nanofluid-heat-and-mass-transfer-in-engineering-problems",publishedDate:"March 15th 2017",bookSignature:"Mohsen Sheikholeslami Kandelousi",coverURL:"https://cdn.intechopen.com/books/images_new/5406.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:"978-953-51-3008-6",printIsbn:"978-953-51-3007-9",pdfIsbn:"978-953-51-6698-6",reviewType:"peer-reviewed",numberOfWosCitations:26,isAvailableForWebshopOrdering:!0,editors:[{id:"185811",title:"Dr.",name:"Mohsen",middleName:null,surname:"Sheikholeslami Kandelousi",slug:"mohsen-sheikholeslami-kandelousi",fullName:"Mohsen Sheikholeslami Kandelousi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"819"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},chapters:[{id:"52694",type:"chapter",title:"Numerical Analysis of Three‐Dimensional MHD Nanofluid Flow over a Stretching Sheet with Convective Boundary Conditions through a Porous Medium",slug:"numerical-analysis-of-three-dimensional-mhd-nanofluid-flow-over-a-stretching-sheet-with-convective-b",totalDownloads:1941,totalCrossrefCites:3,signatures:"Stanford Shateyi",reviewType:"peer-reviewed",authors:[{id:"16056",title:"Dr.",name:"Stanford",middleName:null,surname:"Shateyi",fullName:"Stanford Shateyi",slug:"stanford-shateyi"}]},{id:"52541",type:"chapter",title:"Cattanneo-Christov Heat Flux Model Study for Water-Based CNT Suspended Nanofluid Past a Stretching Surface",slug:"cattanneo-christov-heat-flux-model-study-for-water-based-cnt-suspended-nanofluid-past-a-stretching-s",totalDownloads:1382,totalCrossrefCites:3,signatures:"Noreen Sher Akbar, C. 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1. Introduction
The term “pneumothorax” was coined by a French physician Itard, in 1803 [1]. Pneumothorax is defined as the presence of air in the pleural space. Even though intrapleural pressures are negative throughout the respiratory cycle, air does not enter the pleural space, as the net movement of gases from capillary blood into pleural space requires pleural pressures to be lower than −54 mmHg, which does not occur in normal circumstances. Hence, for air to be present in pleural space, one of the three events must occur: communication between pleural space and alveolar space (or bronchus), or communication between pleural space and the atmosphere, or presence of gas-producing organism in the pleural space [2].
Clinically, pneumothorax is classified as spontaneous (no obvious precipitating factor present) and non spontaneous (consequence of any thoracic injury). Spontaneous pneumothorax may be primary (no apparent underlying lung disease) or secondary (associated with clinically apparent underlying disease, like chronic obstructive pulmonary disease, cystic fibrosis), or catamenial (associated with menstruation). Pneumothorax can be of varying clinical severity, ranging from a small pneumothorax, which is likely to resolve spontaneously, to those with large pleural defects and collapse of entire lung and compromised ventilation.
Pneumothorax ranks second to rib fracture, as the most common manifestation of traumatic chest injury and is noted in 40–50% of patients with chest trauma [3]. Weissberg et al. in a study of 1199 cases of pneumothoraces found secondary spontaneous pneumothorax (505 patients) to be most common, followed by primary spontaneous pneumothorax (218 patients), traumatic pneumothorax (403 patients), and iatrogenic pneumothorax (73 patients) [4].
2. Pathophysiology
Normally, the pressure in pleural space is negative compared to the alveolar pressure during the entire respiratory cycle, due to the inherent elastic recoil of the lung. The pleural pressure is also negative with respect to atmospheric pressure. Development of communication between alveolus or atmosphere and the pleural space allows air to flow into the pleural space until there is no longer a pressure difference or until the communication is sealed [5].
Tension pneumothorax is a condition where there is continuous increase in the air trapped in the pleural space, due to formation of a one-way valve by the injured tissues. This trapped air builds up pressure on the affected side, causing collapse of the ipsilateral lung and shift of mediastinum into the contralateral hemithorax. This causes respiratory distress. Also, there is reduced venous return and thus decreased cardiac output. Further, hypoxia leads to increased pulmonary vascular resistance via vasoconstriction. Cardiopulmonary arrest becomes imminent. Tension pneumothorax, thus, culminates in a life-threatening condition.
Spontaneous rupture of blebs may result in pneumothorax. The rupture may be a consequence of pressure change, as seen in airplane crew members or scuba divers [6]. The volume of given mass of gas at a constant temperature is inversely proportional to its pressure. A given volume of air at an altitude of 3050 m, saturated at body temperature, expands to 1.5 times the volume at sea level. Scuba divers breathe the compressed air delivered by a regulator and during ascent, as ambient pressure falls rapidly, gas in the lungs expands and may rupture blebs [7].
Secondary spontaneous pneumothorax may be due to rupture of pre-existing blebs or due to areas of increased porosity. These are areas of disrupted mesothelial cells on the visceral pleura, replaced by an inflammatory elastofibrotic layer with increased porosity, allowing air leak into the pleural space [8]. Pneumothorax has, also, been reported to be the presenting sign of peripheral necrotic tumour or centrally located tumour.
Catamenial pneumothorax is defined as two episodes of pneumothorax temporally related to the onset of menses, usually within 72 hours. Catamenial pneumothorax is the presentation of thoracic endometriosis and thorax is the most common site of extra pelvic endometriosis. An older age at diagnosis (34.2 ± 6.9 years), and right sided lesions predominate the clinical picture. Thirty-nine percent of patients have associated diaphragmatic lesions. Diverse hypothesis have been advanced to explain the pathogenesis of endometriosis related pneumothorax: spontaneous rupture of blebs, shedding of endometrial implants of visceral pleura, and the transdiaphragmatic crossing of air from the genital tract during menses. Known risk factors associated with thoracic endometriosis include previous gynaecologic surgery (such as curettage for miscarriage, hysteroscopy for endometrial biopsy, or revision of the uterine cavity after caesarean section), primary or secondary infertility, and the history of pelvic endometriosis.
Iatrogenic pneumothorax may be caused during transthoracic needle aspiration or biopsy, subclavian or jugular vein catheterization, thoracocentesis, mechanical ventilation, cardiopulmonary resuscitation, tracheobronchial biopsy, among the commonly reported causes. Rarer reported causes are liposuction of axilla fat, liver biopsy, colonoscopy and gastroscopy [9]. Surgeries with operative fields far removed from thorax, have been reported to be associated with pneumothorax, such as orthognathic surgery [10]. Iatrogenic pneumothorax related to mechanical ventilation has been reported in up to 15% of ventilated patients [11].
Communication between a bronchus (main stem, lobar or sublobar bronchus) and pleural space, called bronchopleural fistula, usually results as a complication of lung-resection surgery. The incidence of bronchopleural fistula is up to 1% after lobectomy and about 4–20% after pneumonectomy [12].
3. Diagnosis
3.1 Clinical examination
On inspection, tachypnea, increased work of breathing and respiratory distress may be seen. Cyanosis, drowsiness and decreased oxygen saturation may be found in tension pneumothorax. On palpation, tachycardia, chest wall tenderness, subcutaneous emphysema, decreased chest wall expansion, decreased tactile fremitus and tracheal shift are noted.
Hyper-resonant notes on percussion over the affected lung fields and decreased air entry perceived on auscultation are indicative of pneumothorax. There may be absent breath sounds on the ipsilateral side with contralateral reduced air entry in tension pneumothorax. Iatrogenic pneumothorax should be suspected in any patient who becomes more dyspneic after a medical or a surgical procedure that is known to be associated with the development of the pneumothorax. Sudden increase in peak airway pressure and sudden decline in oxygen saturation in a patient on mechanical ventilation should ring warning bells for the intensivist.
3.2 Investigation
A chest X-ray may reveal free air around the periphery of the lung fields and decreased lung volume. It may demonstrate the aetiology of the pneumothorax, such as rib or sternal fractures or presence of emphysematous lungs. Films should be taken in erect position, because in supine position, air spreads out in whole of pleural cavity, and films may appear normal, even in the presence of significant air. In patients who cannot be positioned erect and need to be supine, a deep sulcus sign (deep lateral costophrenic angle) should be looked for [13].
Methods to determine the size of pneumothorax on chest X-ray give approximate idea only. There are currently two methods described in adults. If the lateral edge of the lung is >2 cm from the thoracic cage, then, it implies air is occupying at least 50% of thoracic volume and hence, pneumothorax is large in size. Another method is measuring the fractional change in linear dimension of lung, and that multiplied by a factor of three, gives the fractional volume of pneumothorax [14].
Computed tomography (CT) chest provides more accurate information regarding volume of pneumothorax and associated pathology. Obtaining X-ray or CT images may be problematic and time-consuming in poly-trauma patients. Nowadays, in many trauma centres, pneumothorax is detected by sonography and has been included as a part of focused abdominal sonography for trauma (FAST) examination [15]. Ultrasound plays a important role in patients who are not stable enough for chest X-ray and CT. Also, ultrasound is not invasive and the patient is not exposed to radiation. According to a study of Blaivas et al., chest X-ray and ultrasound have a sensitivity of 75.5 and 98.1%, respectively and a specificity of 100 and 99.2%, respectively [16].
Bronchopleural fistula should be suspected in a lung resection patient with large continuous air leak and signs of empyema (leukocytosis, fever, purulent fluid on thoracocentesis, and pleural fluid on chest X-ray or CT scan). Large pneumothorax developing days or weeks after resection is strongly indicative of a bronchopleural fistula. There is often a persistent and worsening cough. Since these patients have high mortality rates, of 11–18% for early fistula (within 30 days of surgery) and 0–7% for late fistula (beyond 30 days of surgery), they should be evaluated thoroughly by CT scan and flexible bronchoscopy. Bronchopleural fistula is separately discussed thoroughly elsewhere.
4. Management
4.1 Initial management
Initial management of pneumothorax patients involves ensuring adequate airway, providing supplemental oxygen, securing an intravenous line, looking for signs of compromised breathing and deciding on the need of tube thoracostomy. Tension pneumothorax should be diagnosed by clinical assessment and a tube thoracostomy/needle thoracocentesis should be performed immediately. Scant data exists in literature proving the efficacy of needle thoracocentesis procedure. However, when tube thoracostomy is anticipated to take time, a needle thoracocentesis may be done immediately, to save life.
Tube thoracostomy is an emergency procedure and is mandatory where pneumothorax is large, or patient has respiratory compromise. Some centres practice drainage of all traumatic pneumothoraces irrespective of symptoms [11]. This line of management in simple pneumothorax is considered invasive by other centres, who recommend observation and oxygen supplementation for small pneumothoraces.
Sucking chest wounds require immediate sealed-cover with an occlusive, air-tight, clean plastic sheet. The sterile inside of gloves-packet can be used in an emergency situation. No patient with penetrating chest wound should be neglected, as tension pneumothorax or life-threatening respiratory emergency can arise.
Upright positioning is beneficial unless contraindicated, like in spinal injury. In a patient with pneumothorax who requires air transport, it is essential that an intercostal tube with Heimlich valve be placed prior to transfer, as pressure changes during flight will cause progression in the severity of the injury and may potentially lead to development of tension pneumothorax.
Pain impairs the ability of the person to breathe, further compromising lung mechanics, in inflammed and contused lungs. In addition, it causes the retention of pulmonary secretions which further suppresses the patient’s cough reflex, finally leading to atelectasis and increasing morbidity, Nonsteroidal anti-inflammatory drugs, systemic opioids or regional analgesia methods such as epidural analgesia, intrapleural analgesia, intercostal nerve block, and thoracic paravertebral block have been used for pain control.
Supplemental oxygen therapy, instead of room air, accelerates the resorption of air in pleural cavity by four-fold. By breathing 100% oxygen instead of air, alveolar pressure of nitrogen falls, and nitrogen is gradually washed out of tissue and oxygen is taken up by vascular system. This builds substantial gradient of nitrogen between tissue capillary and the pneumothorax space, resulting in multifold increase in absorption from pleural space. About 1.25% of the volume of pleural air is absorbed in 1 day; hence 25% of the volume is absorbed in 20 days [17]. Small pneumothoraces are often managed with oxygen administration and monitoring via chest X-rays.
4.2 Tube thoracostomy
Correct placement of the tube is seen as the stream of the bubbles during expiration and coughing and the rise on the level of fluid in the underwater seal during inspiration. Complications of tube thoracostomy include injury to lung or mediastinum, haemorrhage (usually from intercostal artery injury), neurovascular bundle injury, infection, bronchopleural fistula, and subcutaneous or intraperitoneal tube placement.
Heimlich valve or the Vycon self-sucking chest drainage valve are applied directly to the chest tube and reduce or eliminate the underwater drainage period. The Heimlich flutter valve is quite inconspicuous under clothes and makes ambulatory treatment possible. The valve is made of latex rubber that acts as one-way valve, letting air out and preventing reentry. The Vycon device is a double self-sucking valve. It has a soft plastic casing that allows application of manual pressure to aspirate air or fluid [18].
If the lung remains unexpanded or if there is a persistent air leak 72 hours after tube thoracostomy, thoracoscopy or thoracotomy should be considered. Presence of hemopneumothorax, bilateral pneumothorax, first contralateral pneumothorax and pregnancy may be considered for early invasive treatment [19].
Tube thoracostomy is usually sufficient to treat primary spontaneous pneumothorax. However, Schramel et al. reviewed 11 studies over 32 years, involving 1242 patients with primary spontaneous pneumothorax, treated with needle aspiration or tube drainage, and concluded that about 30% patients have recurrence of pneumothorax [20]. Risk factors for recurrence are radiographic evidence of pulmonary fibrosis, smoking, asthenic habitus and younger age [21]. Presence of blebs or bullae was not found to be significantly associated with recurrence [21]. Of patients with recurrent pneumothorax after initial spontaneous pneumothorax, 72% will develop a subsequent pneumothorax within a 2-year period [21]. Recurrent spontaneous pneumothorax or persistent air leaks at initial presentation are indications for operative treatment. Patients in occupations with excessive pressure changes (pilots and divers) or those residing in remote areas, are candidates for operative intervention after a single episode of spontaneous pneumothorax to prevent a potentially life-threatening recurrence.
Clinical picture in secondary spontaneous pneumothorax (SSP) is complicated by the presence of underlying diffuse lung disease, such as chronic obstructive pulmonary disease (COPD), cystic fibrosis, tuberculosis, fibrotic lung diseases such as idiopathic pulmonary fibrosis, and autoimmune diseases involving pleura such as rheumatoid arthritis, ankylosing spondylitis, systemic sclerosis, and Sjogren’s syndrome. Observation without evacuation of the pneumothorax, is usually not possible because these patients usually are very symptomatic. Simple aspiration is less likely to be successful in SSP than in primary pneumothorax [22]. It is attempted as an initial treatment in small (air space <2 cm) pneumothoraces in minimally breathless patients under the age of 50 years. If the patient with SSP is 50 years or older, and if the rim of intrathoracic air is larger than 2 cm on a chest X-ray, intercostal tube drainage is advocated. Clinically unstable patients should have a chest tube inserted, notwithstanding the size of the pneumothorax. Sixty-one to seventy percent of leaks resolve by day seven of tube drainage. Further drainage is unlikely to improve success. If air leak does not stop after 48 hours of continuous drainage, consultation for surgical intervention is recommended because of significantly lower healing rate of pleura in cases of SSP compared with primary spontaneous pneumothorax [23].
Indications for operative treatment include persistent air leak, recurrent pneumothorax, pneumothorax after pneumonectomy or intolerance of the prolonged effects of pneumothorax, not relieved by more conservative approaches.
4.3 Surgical method
Prevention of persistent air leak or future recurrence requires initial identification of the source of the air leak, that is, macroscopic blebs or bullae. Bullae are air filled spaces within the lung parenchyma resulting from the progressive destruction of alveolar tissue. Typically they have relatively thick fibrous walls, grow progressively larger, and are poorly ventilated and with poor perfusion. A giant bulla is defined as one which occupies more than one third of the chest cavity. Complete intrathoracic inspection requires division of all pleural adhesions since these often conceal the culprit lesion. The source of air leak is then controlled by stapling, or suturing.
After completion of the bleb resection, pleurodesis is performed to decrease risk of recurrence. Horio et al. has shown, in a comparative study, that recurrence rate diminished from 16 to 1.9%, when pleurodesis is added to bullectomy [24]. Areas of pleural porosity are potential sources of recurrence, and may be too widespread to be resected. Hence, pleural symphysis is important.
There are three basic approaches to achieve the principles above: thoracostomy, thoracoscopy or thoracotomy. Video-assisted thoracoscopic surgery (VATS) is enabled by the insertion of a 5- to 10-mm videothoracoscope via a 1- to 2-cm incision in the lateral sixth intercostal space. Two more similar incisions are placed anteriorly and inferiorly in the fourth and seventh intercostal space (Figure 1). Instruments are introduced via rigid or flexible ports. Adhesions are taken down with sharp dissection. Bleb excision or bullectomy is carried out with an endoscopic linear cutter. The bullae are deliberately opened by cautery or scissors and allowed to deflate. An endoscopic lung clamp is used to grasp the bulla and is then rotated repeatedly as if winding a clock. This action collapses the bulla onto itself and the demarcation between bulla and normal lung parenchyma is revealed. Small ventilated breaths to the ipsilateral lung can also highlight this transition zone. The endoscopic linear cutter stapler is then used to amputate the base of the bulla (Figure 2). Alternatively, bleb may be ligated using a pre-tied Roeder slip knot, introduced by an external applicator.
Figure 1.
Port placement for blebectomy [25].
Figure 2.
Apical bullectomy using ring forceps and endoscopic stapler [25].
When excising the emphysematous bulla, the staple lines must be reinforced to reduce chance of postoperative air leak. Application of buttress material in the staple line distributes tension throughout the staple line, seals off the staple holes and narrows the spaces between each staple, thus reducing tearing at the staple line. Additionally, the buttress provides a broader pressure profile around each individual staple across the staple line, leading to potentially improved haemostasis. Material such as fibrin glue, bovine pericardium, poly-glycolic acid, polydioxane ribbon, Teflon felt, collagen patches and polytetrafluoroethylene (PTFE) sheets have been used to reinforce staple line. Nonabsorbable synthetic materials carry the potential hazard of inflammation and/or bacterial colonisation. Biomaterials originating from animal tissues have a risk of cross-species transmission of infection.
Accessory ports are removed under direct thoracoscopic guidance and the sites inspected for haemostasis. A 24 or 28 F drain is placed to the apex of the hemithorax. This is brought out of one of the port sites and connected to underwater seal drainage and suction. The lung is inflated under direct vision by the scope to verify complete inflation, locate additional blebs, and insure proper placement of the chest tube to the apex of the hemithorax. An inflated lung can displace a tube 2–3 cm caudally. If not corrected, this will frequently lead to a loculated pneumothorax at the apex and thwart the pleurodesis. The sites are closed in two layers with an absorbable suture.
Open surgery is usually performed via muscle-sparing thoracotomy. A lateral or axillary thoracotomy via the fourth intercostal space preserving the fibres of latissimus dorsi and with minimal rib retraction is the approach of choice. Bullae are opened, bronchial edges are oversewed, edges of the bullae are unfolded and stapled. Exogenous materials are buttressed to minimise postoperative air leak.
Randomised prospective study comparing VATS with axillary thoracotomy found no significant difference in postoperative blood loss, lung function, postoperative pain, use of analgesics, postoperative complications, duration of hospital stay and resumption of normal activities. However, with a minimum follow-up of 2 years the recurrence rate after VATS was 4.3% and after a limited thoracotomy, was 0% [26].
However, for recurrent pneumothorax, a randomised study found significantly longer operative time with VATS. Complication rate, chest tube duration, hospital stay, and incidence of chronic pain were not significantly different [27].
In multiple studies, VATS was found to be associated with higher recurrence rate compared to open thoracotomy [28, 29, 30]. Barker and colleagues performed a meta-analysis by comparing the reported recurrence rates in patients undergoing VATS with those having open surgery. Results showed a four-fold increase when a similar pleurodesis procedure is performed with a video-assisted approach compared with an open approach [28]. One of the reasons attributed to it was insufficient visualisation of bullae or blebs on the lung by thoracoscopy. Another reason quoted was less adhesion between the lungs and the chest wall postoperatively when VATS is performed compared with open thoracotomy. Inspite of this, many thoracic surgeons prefer the VATS approach as it is less invasive, less painful, and associated with a shorter hospital stay [31]. VATS is, thus, now considered approach of choice for elderly patients or those with multiple comorbidities [32, 33].
Migliore et al. approached pneumothorax through single port, using handcrafted 20 mm flexible trocar [31]. Jutley et al. compared the standard three-port VATS and uniVATS for surgical management of spontaneous pneumothorax and demonstrated safety and effectiveness with the latter technique [34]. Reduction of intraoperative blood loss and postoperative pain with a higher patient’s satisfaction score in uniVATS emerged from a propensity matched comparative analysis by Dai et al. [35]. However, retrospective comparison of uniport versus multiport VATS lobectomies by Chang et al. revealed no difference in operative time, postoperative 30-day mortality, chest tube permanence, hospital stay and reoperation rates [36].
More recent advance in the field of thoracic surgery is robotic-assisted surgery. The surgeon sits at a console, away from the patient in operating room and controls the instruments, including camera, on the robotic surgical system. A small 3D high-definition camera is placed through one of the incisions to provide a good view of the chest cavity, while wristed robotic instruments are inserted through the other small incisions.
For bilateral bullous disease, staging the operations is preferred, to minimise morbidity as well as to allow the ipsilateral lung to re-expand completely, optimising the patient’s functional status before tackling the contralateral lesion.
Catamenial pneumothorax with mild symptoms is usually managed with simple rest and thoracocentesis or chest tube for symptomatic relief. The surgical aspects include removal of blebs and bullae, wedge resection, and pleurodesis (abrasion or talc). Most surgical treatment is performed by thoracoscopy, and pleurodesis has been advocated to reduce recurrences. Endometrial deposits on diaphragm are removed as conservatively as possible to spare the diaphragmatic function. Multiple small defects are repaired by titanium clips. The diaphragm is finally reinforced by Prolene or Gore-Tex® mesh. Spiral clips are placed radially at the border of the prosthesis [37]. There is still no agreement regarding whether a prosthetic repair should be recommended. Bagan et al. reported fewer recurrences after diaphragm reinforcement with polyglactin mesh [38]. Concern exists about the use of VATS for large diaphragm defects. Minimally invasive approach is not fully supported by evidence. Both sides of the diaphragm need to be evaluated if one side is noted to have endometrial implants. Superficial diaphragmatic endometriosis can be treated with cold scissors, monopolar energy, bipolar energy, CO2 laser, or a plasma energy source [39]. Bagan et al. suggested application of surgical treatment during menses, for better visualisation of the endometriotic lesions [38].
Postoperative treatment with GnRH agonists or oral contraceptives for 6–12 months is suggested for all patients with proven catamenial pneumothorax for symptomatic relief and to reduce recurrences. The goal of early GnRH analogues administration is to prevent cyclic hormonal changes and induce suppression of ectopic endometrium activity, until accomplishment of effective pleurodesis, since formation of effective pleural adhesions require time [40]. Longer period of hormonal treatment (median 17.5 months) has been required after reoperations for catamenial pneumothorax. Recurrence rate varied from 14.3 to 55%.
4.4 Pleurodesis (mechanical and chemical) and parietal pleurectomy
Pleural symphysis is used to obliterate the potential space between pleural surfaces to prevent recurrent pneumothorax. This is accomplished by inducing an inflammatory reaction between the visceral and parietal surfaces with a chemical agent, mechanical abrasion or by stripping the parietal pleura which results in fusion of the visceral surface to the denuded thoracic wall. Chemical agents include talc, doxycycline, tetracycline, bleomycin, iodopovidone, Corynebacterium parvum and silver nitrate. Mechanical pleurodesis is done by vigorously abrading the parietal pleural surface with tightly rolled gauze, held by ringed forceps or a Bovie scratch pad (Figure 3).
Figure 3.
Method of mechanical pleurodesis [25].
Parietal pleurectomy involves sacrifice of the parietal pleura. With the help of saline infusion in sub-pleural space, the parietal pleura can be bluntly dissected with a end-forceps. Alternatively, electrocautery can be used. Ayed and Chandrasekran suggested that in apical region, pleurectomy might be a more effective procedure than pleural abrasion [41].
In a randomised prospective study of 96 patients, pleurodesis by talc slurry resulted in the lowest recurrence rate of 8%, compared to 13% with tetracycline and 36% with simple tube drainage [42]. Talc is insufflated into the chest so that complete dispersion throughout the hemithorax is accomplished. This is typically accomplished with an atomizer. Alternatively, talc can be blown into the chest from a LUKI tube in front of a 6 L/minute oxygen flow rate. Alternatively, talc slurry can be instilled through a chest tube in patients who are not surgical candidates.
Talc is cheap. Talc instillation carries a low risk. However, complications such as pulmonary edema, acute respiratory distress syndrome, and hypotension have been reported [43, 44]. In an experimental study in rats, rapid absorption of talc from the pleural space was seen and systemic distribution might explain the complications [45]. Thus, size of the talc particles seems important, smaller particles inducing more systemic complications. In a recent prospective European multicentre study, thoracoscopic pleurodesis with 2 g of graded talc consisting of large particles, was found to be safe after a 30 day observation period [46].
Talc induces a painful inflammatory reaction on the pleural surfaces, which requires adequate analgesia. Aggressive pleurodesis methods should be avoided in chronic obstructive pulmonary disease patients who are suitable for lung transplantation, to reduce graft implantation complications.
In a comparative, randomised study including 73 patients with pleural effusion or spontaneous pneumothorax, talc and iodopovidone were found to be equally efficient and safe [47]. Pleurodesis by autologous blood has been initially used by Robinson, for treatment of persistent air leak in spontaneous pneumothorax patients [48]. This method is being widely used as a treatment of choice for air leaks, since pain and fever, which have been reported with other chemical pleurodesis agents, are rarely encountered with this agent [49, 50]. Development of empyema and tension pneumothorax have been reported, which had occurred due to clotting of the blood in the chest tube and care must be taken to prevent it [50].
In children, the management protocols of pneumothorax remain almost the same. In children too, surgery reduces ipsilateral primary spontaneous pneumothorax recurrence. But, surgery is shown to be predictive for contralateral recurrence in them [51]. Perhaps the positive pressure ventilation required during surgery leads to formation of new blebs contralaterally, or to over-distension of already existing contralateral blebs [52].
5. Anaesthesia
VATS is commonly performed under general anaesthesia with split-lung ventilation. The COPD patient’s baseline pulmonary functions are often suboptimal and they may represent a relative contraindication to split-lung ventilation, thus conferring axillary thoracotomy an advantage over VATS. However, postoperative exacerbation of respiratory function or postoperative chest pain has been more effectively avoided with thoracoscopic surgery [53, 54]. To prevent hypoxemia during one-lung ventilation for thoracoscopic surgery, application of continuous positive airway pressure to the non-ventilated lung is performed [55]. More sophisticated techniques using fiberoptic bronchoscopic segmental oxygen insufflation and recruitment have been reported [56].
Awake surgery under epidural anaesthesia might be advocated in case with several thoracic diseases [57, 58]. Though the efficacy and safety of awake surgery are still controversial, and definitive criteria for indications for awake surgery do not exist, studies have shown that the mean time for chest tube drainage, hospital stay, and operative time were shorter in epidural anaesthesia group than in general anaesthesia group. The postoperative pain score was significantly lower in the epidural anaesthesia group. The study proved that well-maintained breathing and hemodynamics during the awake thoracoscopic surgery attenuated the surgical stress responses and had a smaller impact on the postoperative lymphocyte responses when compared with conventional thoracoscopic surgery under general anaesthesia with single-lung ventilation [59, 60].
Another alternative to general anaesthesia with split-lung ventilation is total intravenous anaesthesia, using propofol and sufentanil, with local anaesthesia, using lignocaine, at incision sites and pleural surface. This has been described to have comparable results, while doing away with the adverse effects of epidural anaesthesia, such as epidural hematoma, spinal cord injury and phrenic nerve palsy. Total intravenous anaesthesia is technically demanding, and anaesthesia-related phenomena, such as hypotension and bradycardia, may arise. Anaesthetists have used laryngeal masks to secure the patients’ airway during the procedure, and provided deep sedation without compromising patient safety [61].
In contrast to secondary spontaneous pneumothorax due to COPD, that caused by lung fibrotic disease shows different characteristics—lungs with fibrotic disease are very fragile and shrunken. The postoperative mortality rate is high (three of 14 patients in one study) due to the exacerbation of basic lung disease and also because full expansion of lung is not achieved by applying negative intrathoracic pressure due to low respiratory compliance [62]. Such a pulmonary fibrotic disease that has taken the centre stage among all diseases, is the COVID-19 disease.
6. Pneumothorax in COVID-19 patients
Lungs of patients with COVID-19 who have significant interstitial involvement seem physiologically small, with low compliance and reduced elastance. The thickened, stiff tissue makes it difficult for lungs to expand properly, and sustained-pressure ventilation may be necessary to obtain acceptable gas exchanges. In this setting, fibrotic parenchyma and preexisting emphysematous blebs are prone to rupture, with consequent risk of pneumothorax. Overinflation and high positive end-expiratory pressure in such fibrotic and hypoelastic lungs may cause alveolar or preexisting bleb rupture.
Furthermore, pneumothorax and bulla have been reported in COVID-19 patients who did not have any risk factors for pneumothorax, including mechanical ventilation, history of smoking, or pulmonary comorbidities [63]. The alveolar damage, and bronchiolar distortion and narrowing, caused by fibrosis following resolution of COVID-19 pneumonia, led to pulmonary bullae formation. Moreover, the severe cough associated with viral infections increases the intrapulmonary pressure. This, in turn, may precipitate bullae rupture and pneumothorax formation [64].
Chest tube placement should be considered first-line treatment. Persistence of air leak may constitute an indication for low-tidal volume two-lung ventilation thoracoscopy. Because of stiffer parenchyma, black cartridge staplers are needed for bulla resection. Ideal timing for surgical procedure is unclear. It may be better to do the procedures early in the disease when the interstitial tissues are less traumatised, less fibrotic, and less inflamed [65].
Extra-corporeal membrane oxygenation (ECMO) as a treatment option for pneumothorax with severe ventilator settings has been tried successfully, to reduce ventilator settings and thus, allowing the lungs to rest. This reduced the lung inflation, and avoided over distension of the lungs, while reducing the air leak and allowing the pleura to heal [66, 67].
7. Conclusion
Pneumothorax is a relatively common malady, both in traumatic and non-traumatic setting. The management is initiated by tube thoracostomy and other supportive measures. Presence of underlying lung disease warrants a more aggressive approach. Prevention of recurrence is also crucial, as recurrences are associated with poorer outcome. VATS is an attractive surgical option due to smaller incision and faster recovery. Innovative procedures continue to be described and many will achieve wide acceptability.
\n',keywords:"pneumothorax, tube thoracostomy, VATS, pleurodesis, bullectomy, chest X-ray, flap, COVID-19, intercostal tube",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/80875.pdf",chapterXML:"https://mts.intechopen.com/source/xml/80875.xml",downloadPdfUrl:"/chapter/pdf-download/80875",previewPdfUrl:"/chapter/pdf-preview/80875",totalDownloads:34,totalViews:0,totalCrossrefCites:0,dateSubmitted:"July 3rd 2021",dateReviewed:"October 4th 2021",datePrePublished:"March 18th 2022",datePublished:null,dateFinished:"March 18th 2022",readingETA:"0",abstract:"Pneumothorax is the collection of air in pleural cavity, which is commonly due to development of a communication between pleural space and alveolar space (or bronchus) or the atmosphere. In this chapter, we will discuss the various aetiologies of pneumothorax, the differences in their pathophysiology and the implications on the management of the disease. The chapter focusses on the surgical aspects in the management, the revolution brought in by video-assisted thoracoscopic surgery (VATS) and the advancement of the field by introduction of uniportal VATS and robotic-assisted thoracic surgery. The principles of management of catamenial pneumothorax are revisited. The chapter also throws light on the nuances of anaesthesia techniques and the latest developments are outlined. Lastly, a section is dedicated to COVID-19 associated pneumothorax and the approach to its management.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/80875",risUrl:"/chapter/ris/80875",signatures:"Shilpi Karmakar",book:{id:"11045",type:"book",title:"Pleura - a Surgical Perspective",subtitle:null,fullTitle:"Pleura - a Surgical Perspective",slug:null,publishedDate:null,bookSignature:"Dr. Alberto Sandri",coverURL:"https://cdn.intechopen.com/books/images_new/11045.jpg",licenceType:"CC BY 3.0",editedByType:null,isbn:"978-1-83969-693-0",printIsbn:"978-1-83969-692-3",pdfIsbn:"978-1-83969-694-7",isAvailableForWebshopOrdering:!0,editors:[{id:"50811",title:"Dr.",name:"Alberto",middleName:null,surname:"Sandri",slug:"alberto-sandri",fullName:"Alberto Sandri"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:null,sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Pathophysiology",level:"1"},{id:"sec_3",title:"3. Diagnosis",level:"1"},{id:"sec_3_2",title:"3.1 Clinical examination",level:"2"},{id:"sec_4_2",title:"3.2 Investigation",level:"2"},{id:"sec_6",title:"4. Management",level:"1"},{id:"sec_6_2",title:"4.1 Initial management",level:"2"},{id:"sec_7_2",title:"4.2 Tube thoracostomy",level:"2"},{id:"sec_8_2",title:"4.3 Surgical method",level:"2"},{id:"sec_9_2",title:"4.4 Pleurodesis (mechanical and chemical) and parietal pleurectomy",level:"2"},{id:"sec_11",title:"5. Anaesthesia",level:"1"},{id:"sec_12",title:"6. Pneumothorax in COVID-19 patients",level:"1"},{id:"sec_13",title:"7. Conclusion",level:"1"}],chapterReferences:[{id:"B1",body:'Henry M, Arnold T, Harvey J. Pleural Diseases Group Standards of Care Committee, British Thoracic Society. BTS guidelines for the management of spontaneous pneumothorax. Thorax. 2003;58:ii39-ii52'},{id:"B2",body:'Noppen M. Spontaneous pneumothorax: Epidemiology, pathophysiology and cause. 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The Annals of Thoracic Surgery. 2010;90:973-978'},{id:"B61",body:'Guo Z, Yin W, Wang W, Zhang J, Zhang X, Peng G, et al. Spontaneous ventilation anaesthesia: Total intravenous anaesthesia with local anaesthesia or thoracic epidural anaesthesia for thoracoscopic bullectomy. European Journal of Cardio-Thoracic Surgery. 2016;50:927-932'},{id:"B62",body:'Mouroux J, Elkaïm D, Padovani B, et al. Video-assisted thoracoscopic treatment of spontaneous pneumothorax: Technique and results of one hundred cases. The Journal of Thoracic and Cardiovascular Surgery. 1996;112:385-391'},{id:"B63",body:'Yamaya T, Baba T, Hagiwara E, Ikeda S, Niwa T, Kitayama T, et al. Pneumothorax in a COVID-19 pneumonia patient without underlying risk factors. Internal Medicine. 2020;59:2921-2925'},{id:"B64",body:'Ruibing LM, Xin LM. Diagnosis and treatment of severe COVID-19 complicated with spontaneous pneumothorax: A case report. Advanced Ultrasound in Diagnosis and Therapy. 2020;4:142'},{id:"B65",body:'Aiolfi A, Biraghi T, Montisci A, Bonita G, Micheletto G, Donatelli F, et al. Management of persistant pneumothorax with thoracoscopy and bleb resection in COVID-19 patients. The Annals of Thoracic Surgery. 2020;110:e413-e415'},{id:"B66",body:'Ramanathan K, Antognini D, Combes A, et al. Planning and provision of ECMO services for severe ARDS during the COVID-19 pandemic and other outbreaks of emerging infectious diseases. The Lancet Respiratory Medicine. 2020;8:518-526'},{id:"B67",body:'Nakatsutsumi K, Sekiya K, Urushibata N, Hosoi M, Arai H, Nagaoka E, et al. A successful case of extracorporeal membrane oxygenation treatment for intractable pneumothorax in a patient with COVID-19. Acute Medicine & Surgery. 2020;7:e612'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Shilpi Karmakar",address:"drshilpikarmakar@rediffmail.com",affiliation:'
Department of Burns and Plastic Surgery, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India
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One experimental earthen pond of 500 m2 was provided with AquaMats® increasing the surface substrate area 12 times and water quality, phytoplankton and zooplankton populations developed during almost 100 days was compared with a pond without AquaMats®. Their presence favored the development of Dinoflagellates (Miozoa, Dinophyceae), mostly Gymnodiniales, which may be of some concern since some species of this group have been associated with toxic algal blooms while in the ponds without AquaMats® Diatoms (Bacillariophyta) predominate. In both ponds plankton production was very much sculptured by external nutrients added to the systems. The balance between different nutrients is extremely important to regulate the phytoplankton populations with Diatoms blooming at silicate concentrations higher than 2 μM and below this level and at low nitrate and high ammonium being more appropriate for Dinoflagellates. The linkage between phytoplankton and zooplankton population in ponds is strong with zooplankton exerting control over the phytoplankton population and vice-versa. The use of vertical substrates enhances plankton productivity by increasing the substrate area for periphyton fixation. 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UK Research and Innovation (former Research Councils UK (RCUK) - including AHRC, BBSRC, ESRC, EPSRC, MRC, NERC, STFC.) Processing charges for books/book chapters can be covered through RCUK block grants which are allocated to most universities in the UK, which then handle the OA publication funding requests. It is at the discretion of the university whether it will approve the request.)
Wellcome Trust (Funding available only to Wellcome-funded researchers/grantees)
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Chls are located in the membrane of thylakoids where they constitute the two photosystems (PSII and PSI) of terrestrial plants, responsible for both light absorption and transduction of chemical energy via photosynthesis. The high efficiency of photosystems in terms of light absorption correlates with the need to protect themselves against absorption of excess light, a process that leads to the so-called photoinhibition. Dynamic photoinhibition consists of the downregulation of photosynthesis quantum yield and a series of photo-protective mechanisms aimed to reduce the amount of light reaching the chloroplast and/or to counteract the production of reactive oxygen species (ROS) that can be grouped in: (i) the first line of chloroplast defence: non-photochemical quenching (NPQ), that is, the dissipation of excess excitation light as heat, a process that takes place in the external antennae of PSII and in which other pigments, that is carotenoids, are directly involved; (ii) the second line of defence: enzymatic antioxidant and antioxidant molecules that scavenge the generated ROS; alternative electron transport (cyclic electron transport, pseudo-cyclic electron flow, chlororespiration and water-water cycle) can efficiently prevent the over-reduction of electron flow, and reduced ferredoxin (Fd) plays a key role in this context.",book:{id:"5841",slug:"chlorophyll",title:"Chlorophyll",fullTitle:"Chlorophyll"},signatures:"Lucia Guidi, Massimiliano Tattini and Marco Landi",authors:[{id:"198635",title:"Prof.",name:"Lucia",middleName:null,surname:"Guidi",slug:"lucia-guidi",fullName:"Lucia Guidi"},{id:"199774",title:"Dr.",name:"Massimiliano",middleName:null,surname:"Tattini",slug:"massimiliano-tattini",fullName:"Massimiliano Tattini"},{id:"199775",title:"Dr.",name:"Marco",middleName:null,surname:"Landi",slug:"marco-landi",fullName:"Marco Landi"}]},{id:"54601",doi:"10.5772/67955",title:"Chlorophyll as Photosensitizer in Dye-Sensitized Solar Cells",slug:"chlorophyll-as-photosensitizer-in-dye-sensitized-solar-cells",totalDownloads:2918,totalCrossrefCites:8,totalDimensionsCites:15,abstract:"Chlorophyll, being the most abundant pigment that commonly found in plants, bacteria, bryophytes and algae, plays a vital role in photosynthesis. Chlorophylls are natural pigments and therefore safe, environmental friendly, easily available and cheap. Chlorophyll has been experimented to function as a photosensitizer in dye-sensitized solar cells (DSSCs) as DSSCs mimic the photosynthesis process in green plants. DSSC was first developed by Gratzel in 1991 and since then has gained tremendous attention as its fabrication is cheap and easy. A DSSC basically comprises a semiconductor that has been soaked in sensitizing dye (chlorophyll), a counter electrode, and an electrolyte containing a redox mediator. The dye absorbs light, which is transformed into electricity. Chlorophyll can be extracted from the leaves of pomegranate, bougainvillea, papaya, Pandanus amaryllifolius, spinach, green grasses, seaweeds, algae and bryophytes. Chlorophyll from these sources has been studied as possible photosensitizers for DSSCs. Most researches done in chlorophyll DSSC use the extracted natural pigments. The type of solvent and pH of the dye solution will also affect the stability of chlorophyll and subsequently the performance of the DSSCs. This chapter will present an inexhaustive overview on DSSCs using chlorophyll as dye.",book:{id:"5841",slug:"chlorophyll",title:"Chlorophyll",fullTitle:"Chlorophyll"},signatures:"Abdul Kariem Arof and Teo Li Ping",authors:[{id:"186084",title:"Dr.",name:"Abdul Kariem",middleName:null,surname:"Arof",slug:"abdul-kariem-arof",fullName:"Abdul Kariem Arof"},{id:"199862",title:"Dr.",name:"L.P.",middleName:null,surname:"Teo",slug:"l.p.-teo",fullName:"L.P. Teo"}]},{id:"54681",doi:"10.5772/67991",title:"Effects on the Photosynthetic Activity of Algae after Exposure to Various Organic and Inorganic Pollutants: Review",slug:"effects-on-the-photosynthetic-activity-of-algae-after-exposure-to-various-organic-and-inorganic-poll",totalDownloads:2649,totalCrossrefCites:6,totalDimensionsCites:13,abstract:"Algal studies remain necessary for risk assessment and their utility in ecotoxicology is the evaluation of lethal and sub-lethal toxic effects of potential toxicants on inhabitants of several ecosystems. Effects on algal photosynthetic apparatus caused by various chemical species have been extensively studied. The present chapter summarizes the published data concerning the toxicity of various organic and inorganic pollutants such as oils, pesticides, antifoulants and metals on photosynthesis of aquatic primary producers. Biochemical mode of action resulting in the disruption of photosynthesis depends on the chemical’s nature and the characteristics of the exposed microorganism. Observed differences in response and sensitivity by different species to the same toxicant were attributed to several algal characteristics including photosynthetic capacity, pigment type, cellular lipid and protein content, and cell size. Single species bioassays either for one chemical alone or in mixture have been well reported and tolerance of both marine and freshwater water-column phytoplaktonic species has been examined. Adequate published information on multispecies tests (communities) in laboratory and field studies exists. However, risk assessment on photosynthesis of microbenthic periphyton is inadequate, though it is essential especially for hydrophobic organic molecules. Further studies are required to evaluate the adverse effects of metabolites on aquatic microalgae.",book:{id:"5841",slug:"chlorophyll",title:"Chlorophyll",fullTitle:"Chlorophyll"},signatures:"Andreas S. Petsas and Maria C. Vagi",authors:[{id:"200196",title:"Dr.",name:"Andreas",middleName:null,surname:"Petsas",slug:"andreas-petsas",fullName:"Andreas Petsas"},{id:"200198",title:"Dr.",name:"Maria",middleName:null,surname:"Vagi",slug:"maria-vagi",fullName:"Maria Vagi"}]},{id:"54510",doi:"10.5772/67913",title:"Light‐Emitting Diodes: Progress in Plant Micropropagation",slug:"light-emitting-diodes-progress-in-plant-micropropagation",totalDownloads:2153,totalCrossrefCites:2,totalDimensionsCites:12,abstract:"In commercial micropropagation laboratories, the light source is one of the most important factors controlling plant morphogenesis and metabolism of plant cells and tissue and organ cultures. Lamp manufacturers have begun to rate lamps specifically for plant needs. The traditional light source used for in vitro propagation is fluorescent lamps (FLs). However, power consumption in FL use is expensive and produces a wide range of wavelengths (350–750 nm) unnecessary for plant development. Light‐emitting diodes (LEDs) have recently emerged as an alternative for commercial micropropagation. The flexibility of matching LED wavelengths to plant photoreceptors may provide more optimal production, influencing plant morphology and chlorophyll content. Although previous reports have confirmed physiological effects of LED light quality on morphogenesis and growth of several plantlets in vitro, these study results showed that LED light is more suitable for plant morphogenesis and growth than FLs. However, the responses vary according to plant species. This chapter describes the applications and benefits of LED lamps on chlorophyll in plant micropropagation. Two study cases are exposed, Anthurium (Anthurium andreanum) and moth orchids (Phalaenopsisis sp.), both species with economic importance as ornamental plants, where LEDs have a positive effect on in vitro development and chlorophyll content.",book:{id:"5841",slug:"chlorophyll",title:"Chlorophyll",fullTitle:"Chlorophyll"},signatures:"Jericó J. Bello‐Bello, Juan A. Pérez‐Sato, Carlos A. Cruz‐Cruz and\nEduardo Martínez‐Estrada",authors:[{id:"197218",title:"Dr.",name:"Jericó Jabín",middleName:null,surname:"Bello Bello",slug:"jerico-jabin-bello-bello",fullName:"Jericó Jabín Bello Bello"},{id:"197368",title:"MSc.",name:"Eduardo",middleName:null,surname:"Martínez Estrada",slug:"eduardo-martinez-estrada",fullName:"Eduardo Martínez Estrada"},{id:"197369",title:"Dr.",name:"Carlos Alberto",middleName:null,surname:"Cruz Cruz",slug:"carlos-alberto-cruz-cruz",fullName:"Carlos Alberto Cruz Cruz"},{id:"205358",title:"Dr.",name:"Juan Antonio",middleName:null,surname:"Pérez-Sato",slug:"juan-antonio-perez-sato",fullName:"Juan Antonio Pérez-Sato"}]},{id:"54702",doi:"10.5772/67610",title:"Effects of pH and Phosphorus Concentrations on the Chlorophyll Responses of Salvia chamelaeagnea (Lamiaceae) Grown in Hydroponics",slug:"effects-of-ph-and-phosphorus-concentrations-on-the-chlorophyll-responses-of-salvia-chamelaeagnea-lam",totalDownloads:1481,totalCrossrefCites:2,totalDimensionsCites:3,abstract:"Salvia chamelaeagnea (Lamiaceae) is a slow growing water‐wise evergreen shrub originating from the western province of South Africa. It is an attractive landscape, and S. chamelaeagnea is a medicinal plant. It is important to develop enhanced cultivation protocols that could result in high yield and high‐quality medicinal materials. Chlorophyll is a fundamental part of the light‐dependent reactions of the photosynthesis process. This chapter investigates the effects of four phosphorus concentrations and three pH levels of supplied irrigated water on the production of chlorophyll A, chlorophyll B, total chlorophyll, leaf colour and the nutrient uptake of S. chamelaeagnea grown in hydroponics over an 8‐week period at the Cape Peninsula University of Technology. The treatments of pH 4, pH 6 and pH 8 at 31, 90, 150 and 210 ppm of phosphorus were received by 12 groups of plants and were replicated 10 times. The results indicated that at pH 4, P fertilization significantly (P < 0.05) induced a higher chlorophyll production of S. chamelaeagnea grown in hydroponics compared to other pH treatments (pH 8 and pH 6).",book:{id:"5841",slug:"chlorophyll",title:"Chlorophyll",fullTitle:"Chlorophyll"},signatures:"Kerwin Lefever, Charles P. Laubscher, Patrick A. Ndakidemi and Felix\nNchu",authors:[{id:"200292",title:"Dr.",name:"Felix",middleName:null,surname:"Nchu",slug:"felix-nchu",fullName:"Felix Nchu"},{id:"200819",title:"Prof.",name:"Charles",middleName:"Petrus",surname:"Petrus Laubscher",slug:"charles-petrus-laubscher",fullName:"Charles Petrus Laubscher"},{id:"201292",title:"Mr.",name:"Kerwin",middleName:null,surname:"Lefever",slug:"kerwin-lefever",fullName:"Kerwin Lefever"},{id:"201293",title:"Prof.",name:"Patrick A.",middleName:null,surname:"Ndakedemi",slug:"patrick-a.-ndakedemi",fullName:"Patrick A. Ndakedemi"}]}],mostDownloadedChaptersLast30Days:[{id:"54681",title:"Effects on the Photosynthetic Activity of Algae after Exposure to Various Organic and Inorganic Pollutants: Review",slug:"effects-on-the-photosynthetic-activity-of-algae-after-exposure-to-various-organic-and-inorganic-poll",totalDownloads:2649,totalCrossrefCites:6,totalDimensionsCites:13,abstract:"Algal studies remain necessary for risk assessment and their utility in ecotoxicology is the evaluation of lethal and sub-lethal toxic effects of potential toxicants on inhabitants of several ecosystems. Effects on algal photosynthetic apparatus caused by various chemical species have been extensively studied. The present chapter summarizes the published data concerning the toxicity of various organic and inorganic pollutants such as oils, pesticides, antifoulants and metals on photosynthesis of aquatic primary producers. Biochemical mode of action resulting in the disruption of photosynthesis depends on the chemical’s nature and the characteristics of the exposed microorganism. Observed differences in response and sensitivity by different species to the same toxicant were attributed to several algal characteristics including photosynthetic capacity, pigment type, cellular lipid and protein content, and cell size. Single species bioassays either for one chemical alone or in mixture have been well reported and tolerance of both marine and freshwater water-column phytoplaktonic species has been examined. Adequate published information on multispecies tests (communities) in laboratory and field studies exists. However, risk assessment on photosynthesis of microbenthic periphyton is inadequate, though it is essential especially for hydrophobic organic molecules. Further studies are required to evaluate the adverse effects of metabolites on aquatic microalgae.",book:{id:"5841",slug:"chlorophyll",title:"Chlorophyll",fullTitle:"Chlorophyll"},signatures:"Andreas S. Petsas and Maria C. Vagi",authors:[{id:"200196",title:"Dr.",name:"Andreas",middleName:null,surname:"Petsas",slug:"andreas-petsas",fullName:"Andreas Petsas"},{id:"200198",title:"Dr.",name:"Maria",middleName:null,surname:"Vagi",slug:"maria-vagi",fullName:"Maria Vagi"}]},{id:"54510",title:"Light‐Emitting Diodes: Progress in Plant Micropropagation",slug:"light-emitting-diodes-progress-in-plant-micropropagation",totalDownloads:2153,totalCrossrefCites:2,totalDimensionsCites:12,abstract:"In commercial micropropagation laboratories, the light source is one of the most important factors controlling plant morphogenesis and metabolism of plant cells and tissue and organ cultures. Lamp manufacturers have begun to rate lamps specifically for plant needs. The traditional light source used for in vitro propagation is fluorescent lamps (FLs). However, power consumption in FL use is expensive and produces a wide range of wavelengths (350–750 nm) unnecessary for plant development. Light‐emitting diodes (LEDs) have recently emerged as an alternative for commercial micropropagation. The flexibility of matching LED wavelengths to plant photoreceptors may provide more optimal production, influencing plant morphology and chlorophyll content. Although previous reports have confirmed physiological effects of LED light quality on morphogenesis and growth of several plantlets in vitro, these study results showed that LED light is more suitable for plant morphogenesis and growth than FLs. However, the responses vary according to plant species. This chapter describes the applications and benefits of LED lamps on chlorophyll in plant micropropagation. Two study cases are exposed, Anthurium (Anthurium andreanum) and moth orchids (Phalaenopsisis sp.), both species with economic importance as ornamental plants, where LEDs have a positive effect on in vitro development and chlorophyll content.",book:{id:"5841",slug:"chlorophyll",title:"Chlorophyll",fullTitle:"Chlorophyll"},signatures:"Jericó J. Bello‐Bello, Juan A. Pérez‐Sato, Carlos A. Cruz‐Cruz and\nEduardo Martínez‐Estrada",authors:[{id:"197218",title:"Dr.",name:"Jericó Jabín",middleName:null,surname:"Bello Bello",slug:"jerico-jabin-bello-bello",fullName:"Jericó Jabín Bello Bello"},{id:"197368",title:"MSc.",name:"Eduardo",middleName:null,surname:"Martínez Estrada",slug:"eduardo-martinez-estrada",fullName:"Eduardo Martínez Estrada"},{id:"197369",title:"Dr.",name:"Carlos Alberto",middleName:null,surname:"Cruz Cruz",slug:"carlos-alberto-cruz-cruz",fullName:"Carlos Alberto Cruz Cruz"},{id:"205358",title:"Dr.",name:"Juan Antonio",middleName:null,surname:"Pérez-Sato",slug:"juan-antonio-perez-sato",fullName:"Juan Antonio Pérez-Sato"}]},{id:"54559",title:"Introductory Chapter: Chlorophyll Molecules and Their Technological Relevance",slug:"introductory-chapter-chlorophyll-molecules-and-their-technological-relevance",totalDownloads:1630,totalCrossrefCites:1,totalDimensionsCites:2,abstract:null,book:{id:"5841",slug:"chlorophyll",title:"Chlorophyll",fullTitle:"Chlorophyll"},signatures:"Maria Isabel Queiroz, Andrêssa Silva Fernandes, Mariany Costa\nDeprá, Eduardo Jacob-Lopes and Leila Queiroz Zepka",authors:[{id:"171980",title:"Dr.",name:"Eduardo",middleName:null,surname:"Jacob-Lopes",slug:"eduardo-jacob-lopes",fullName:"Eduardo Jacob-Lopes"},{id:"200454",title:"Dr.",name:"Andrêssa",middleName:null,surname:"Fernandes",slug:"andressa-fernandes",fullName:"Andrêssa Fernandes"},{id:"200455",title:"Dr.",name:"Mariany",middleName:null,surname:"Deprá",slug:"mariany-depra",fullName:"Mariany Deprá"},{id:"200457",title:"Prof.",name:"Maria Isabel",middleName:null,surname:"Queiroz",slug:"maria-isabel-queiroz",fullName:"Maria Isabel Queiroz"},{id:"261969",title:"Dr.",name:"Leila",middleName:null,surname:"Queiroz Zepka",slug:"leila-queiroz-zepka",fullName:"Leila Queiroz Zepka"}]},{id:"54601",title:"Chlorophyll as Photosensitizer in Dye-Sensitized Solar Cells",slug:"chlorophyll-as-photosensitizer-in-dye-sensitized-solar-cells",totalDownloads:2918,totalCrossrefCites:8,totalDimensionsCites:15,abstract:"Chlorophyll, being the most abundant pigment that commonly found in plants, bacteria, bryophytes and algae, plays a vital role in photosynthesis. Chlorophylls are natural pigments and therefore safe, environmental friendly, easily available and cheap. Chlorophyll has been experimented to function as a photosensitizer in dye-sensitized solar cells (DSSCs) as DSSCs mimic the photosynthesis process in green plants. DSSC was first developed by Gratzel in 1991 and since then has gained tremendous attention as its fabrication is cheap and easy. A DSSC basically comprises a semiconductor that has been soaked in sensitizing dye (chlorophyll), a counter electrode, and an electrolyte containing a redox mediator. The dye absorbs light, which is transformed into electricity. Chlorophyll can be extracted from the leaves of pomegranate, bougainvillea, papaya, Pandanus amaryllifolius, spinach, green grasses, seaweeds, algae and bryophytes. Chlorophyll from these sources has been studied as possible photosensitizers for DSSCs. Most researches done in chlorophyll DSSC use the extracted natural pigments. The type of solvent and pH of the dye solution will also affect the stability of chlorophyll and subsequently the performance of the DSSCs. This chapter will present an inexhaustive overview on DSSCs using chlorophyll as dye.",book:{id:"5841",slug:"chlorophyll",title:"Chlorophyll",fullTitle:"Chlorophyll"},signatures:"Abdul Kariem Arof and Teo Li Ping",authors:[{id:"186084",title:"Dr.",name:"Abdul Kariem",middleName:null,surname:"Arof",slug:"abdul-kariem-arof",fullName:"Abdul Kariem Arof"},{id:"199862",title:"Dr.",name:"L.P.",middleName:null,surname:"Teo",slug:"l.p.-teo",fullName:"L.P. Teo"}]},{id:"54702",title:"Effects of pH and Phosphorus Concentrations on the Chlorophyll Responses of Salvia chamelaeagnea (Lamiaceae) Grown in Hydroponics",slug:"effects-of-ph-and-phosphorus-concentrations-on-the-chlorophyll-responses-of-salvia-chamelaeagnea-lam",totalDownloads:1482,totalCrossrefCites:2,totalDimensionsCites:3,abstract:"Salvia chamelaeagnea (Lamiaceae) is a slow growing water‐wise evergreen shrub originating from the western province of South Africa. It is an attractive landscape, and S. chamelaeagnea is a medicinal plant. It is important to develop enhanced cultivation protocols that could result in high yield and high‐quality medicinal materials. Chlorophyll is a fundamental part of the light‐dependent reactions of the photosynthesis process. This chapter investigates the effects of four phosphorus concentrations and three pH levels of supplied irrigated water on the production of chlorophyll A, chlorophyll B, total chlorophyll, leaf colour and the nutrient uptake of S. chamelaeagnea grown in hydroponics over an 8‐week period at the Cape Peninsula University of Technology. The treatments of pH 4, pH 6 and pH 8 at 31, 90, 150 and 210 ppm of phosphorus were received by 12 groups of plants and were replicated 10 times. The results indicated that at pH 4, P fertilization significantly (P < 0.05) induced a higher chlorophyll production of S. chamelaeagnea grown in hydroponics compared to other pH treatments (pH 8 and pH 6).",book:{id:"5841",slug:"chlorophyll",title:"Chlorophyll",fullTitle:"Chlorophyll"},signatures:"Kerwin Lefever, Charles P. Laubscher, Patrick A. Ndakidemi and Felix\nNchu",authors:[{id:"200292",title:"Dr.",name:"Felix",middleName:null,surname:"Nchu",slug:"felix-nchu",fullName:"Felix Nchu"},{id:"200819",title:"Prof.",name:"Charles",middleName:"Petrus",surname:"Petrus Laubscher",slug:"charles-petrus-laubscher",fullName:"Charles Petrus Laubscher"},{id:"201292",title:"Mr.",name:"Kerwin",middleName:null,surname:"Lefever",slug:"kerwin-lefever",fullName:"Kerwin Lefever"},{id:"201293",title:"Prof.",name:"Patrick A.",middleName:null,surname:"Ndakedemi",slug:"patrick-a.-ndakedemi",fullName:"Patrick A. 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The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. 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Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:9,paginationItems:[{id:"14",title:"Cell and Molecular Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",slug:"rosa-maria-martinez-espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",biography:"Dr. Rosa María Martínez-Espinosa has been a Spanish Full Professor since 2020 (Biochemistry and Molecular Biology) and is currently Vice-President of International Relations and Cooperation development and leader of the research group 'Applied Biochemistry” (University of Alicante, Spain). Other positions she has held at the university include Vice-Dean of Master Programs, Vice-Dean of the Degree in Biology and Vice-Dean for Mobility and Enterprise and Engagement at the Faculty of Science (University of Alicante). She received her Bachelor in Biology in 1998 (University of Alicante) and her PhD in 2003 (Biochemistry, University of Alicante). She undertook post-doctoral research at the University of East Anglia (Norwich, U.K. 2004-2005; 2007-2008).\nHer multidisciplinary research focuses on investigating archaea and their potential applications in biotechnology. She has an H-index of 21. She has authored one patent and has published more than 70 indexed papers and around 60 book chapters.\nShe has contributed to more than 150 national and international meetings during the last 15 years. Her research interests include archaea metabolism, enzymes purification and characterization, gene regulation, carotenoids and bioplastics production, antioxidant\ncompounds, waste water treatments, and brines bioremediation.\nRosa María’s other roles include editorial board member for several journals related\nto biochemistry, reviewer for more than 60 journals (biochemistry, molecular biology, biotechnology, chemistry and microbiology) and president of several organizing committees in international meetings related to the N-cycle or respiratory processes.",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"79367",title:"Dr.",name:"Ana Isabel",middleName:null,surname:"Flores",slug:"ana-isabel-flores",fullName:"Ana Isabel Flores",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRpIOQA0/Profile_Picture_1632418099564",institutionString:null,institution:{name:"Hospital Universitario 12 De Octubre",institutionURL:null,country:{name:"Spain"}}},{id:"328234",title:"Ph.D.",name:"Christian",middleName:null,surname:"Palavecino",slug:"christian-palavecino",fullName:"Christian Palavecino",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000030DhEhQAK/Profile_Picture_1628835318625",institutionString:null,institution:{name:"Central University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"186585",title:"Dr.",name:"Francisco Javier",middleName:null,surname:"Martin-Romero",slug:"francisco-javier-martin-romero",fullName:"Francisco Javier Martin-Romero",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSB3HQAW/Profile_Picture_1631258137641",institutionString:null,institution:{name:"University of Extremadura",institutionURL:null,country:{name:"Spain"}}}]},{id:"15",title:"Chemical Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",slug:"sukru-beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",biography:"Dr. Şükrü Beydemir obtained a BSc in Chemistry in 1995 from Yüzüncü Yıl University, MSc in Biochemistry in 1998, and PhD in Biochemistry in 2002 from Atatürk University, Turkey. He performed post-doctoral studies at Max-Planck Institute, Germany, and University of Florence, Italy in addition to making several scientific visits abroad. He currently works as a Full Professor of Biochemistry in the Faculty of Pharmacy, Anadolu University, Turkey. Dr. Beydemir has published over a hundred scientific papers spanning protein biochemistry, enzymology and medicinal chemistry, reviews, book chapters and presented several conferences to scientists worldwide. He has received numerous publication awards from various international scientific councils. He serves in the Editorial Board of several international journals. Dr. Beydemir is also Rector of Bilecik Şeyh Edebali University, Turkey.",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",slug:"deniz-ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",biography:"Dr. Deniz Ekinci obtained a BSc in Chemistry in 2004, MSc in Biochemistry in 2006, and PhD in Biochemistry in 2009 from Atatürk University, Turkey. He studied at Stetson University, USA, in 2007-2008 and at the Max Planck Institute of Molecular Cell Biology and Genetics, Germany, in 2009-2010. Dr. Ekinci currently works as a Full Professor of Biochemistry in the Faculty of Agriculture and is the Head of the Enzyme and Microbial Biotechnology Division, Ondokuz Mayıs University, Turkey. He is a member of the Turkish Biochemical Society, American Chemical Society, and German Genetics society. Dr. Ekinci published around ninety scientific papers, reviews and book chapters, and presented several conferences to scientists. He has received numerous publication awards from several scientific councils. Dr. Ekinci serves as the Editor in Chief of four international books and is involved in the Editorial Board of several international journals.",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null,editorialBoard:[{id:"241413",title:"Dr.",name:"Azhar",middleName:null,surname:"Rasul",slug:"azhar-rasul",fullName:"Azhar Rasul",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRT1oQAG/Profile_Picture_1635251978933",institutionString:null,institution:{name:"Government College University, Faisalabad",institutionURL:null,country:{name:"Pakistan"}}},{id:"178316",title:"Ph.D.",name:"Sergey",middleName:null,surname:"Sedykh",slug:"sergey-sedykh",fullName:"Sergey Sedykh",profilePictureURL:"https://mts.intechopen.com/storage/users/178316/images/system/178316.jfif",institutionString:null,institution:{name:"Novosibirsk State University",institutionURL:null,country:{name:"Russia"}}}]},{id:"17",title:"Metabolism",coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",slug:"yannis-karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",biography:"Yannis Karamanos, born in Greece in 1953, completed his pre-graduate studies at the Université Pierre et Marie Curie, Paris, then his Masters and Doctoral degree at the Université de Lille (1983). He was associate professor at the University of Limoges (1987) before becoming full professor of biochemistry at the Université d’Artois (1996). He worked on the structure-function relationships of glycoconjugates and his main project was the investigations on the biological roles of the de-N-glycosylation enzymes (Endo-N-acetyl-β-D-glucosaminidase and peptide-N4-(N-acetyl-β-glucosaminyl) asparagine amidase). From 2002 he contributes to the understanding of the Blood-brain barrier functioning using proteomics approaches. He has published more than 70 papers. His teaching areas are energy metabolism and regulation, integration and organ specialization and metabolic adaptation.",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"243049",title:"Dr.",name:"Anca",middleName:null,surname:"Pantea Stoian",slug:"anca-pantea-stoian",fullName:"Anca Pantea Stoian",profilePictureURL:"https://mts.intechopen.com/storage/users/243049/images/system/243049.jpg",institutionString:null,institution:{name:"Carol Davila University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"203824",title:"Dr.",name:"Attilio",middleName:null,surname:"Rigotti",slug:"attilio-rigotti",fullName:"Attilio Rigotti",profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institutionString:null,institution:{name:"Pontifical Catholic University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"300470",title:"Dr.",name:"Yanfei (Jacob)",middleName:null,surname:"Qi",slug:"yanfei-(jacob)-qi",fullName:"Yanfei (Jacob) Qi",profilePictureURL:"https://mts.intechopen.com/storage/users/300470/images/system/300470.jpg",institutionString:null,institution:{name:"Centenary Institute of Cancer Medicine and Cell Biology",institutionURL:null,country:{name:"Australia"}}}]},{id:"18",title:"Proteomics",coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",slug:"paolo-iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",biography:"Paolo Iadarola graduated with a degree in Chemistry from the University of Pavia (Italy) in July 1972. He then worked as an Assistant Professor at the Faculty of Science of the same University until 1984. In 1985, Prof. Iadarola became Associate Professor at the Department of Biology and Biotechnologies of the University of Pavia and retired in October 2017. Since then, he has been working as an Adjunct Professor in the same Department at the University of Pavia. His research activity during the first years was primarily focused on the purification and structural characterization of enzymes from animal and plant sources. During this period, Prof. Iadarola familiarized himself with the conventional techniques used in column chromatography, spectrophotometry, manual Edman degradation, and electrophoresis). Since 1995, he has been working on: i) the determination in biological fluids (serum, urine, bronchoalveolar lavage, sputum) of proteolytic activities involved in the degradation processes of connective tissue matrix, and ii) on the identification of biological markers of lung diseases. In this context, he has developed and validated new methodologies (e.g., Capillary Electrophoresis coupled to Laser-Induced Fluorescence, CE-LIF) whose application enabled him to determine both the amounts of biochemical markers (Desmosines) in urine/serum of patients affected by Chronic Obstructive Pulmonary Disease (COPD) and the activity of proteolytic enzymes (Human Neutrophil Elastase, Cathepsin G, Pseudomonas aeruginosa elastase) in sputa of these patients. More recently, Prof. Iadarola was involved in developing techniques such as two-dimensional electrophoresis coupled to liquid chromatography/mass spectrometry (2DE-LC/MS) for the proteomic analysis of biological fluids aimed at the identification of potential biomarkers of different lung diseases. He is the author of about 150 publications (According to Scopus: H-Index: 23; Total citations: 1568- According to WOS: H-Index: 20; Total Citations: 1296) of peer-reviewed international journals. He is a Consultant Reviewer for several journals, including the Journal of Chromatography A, Journal of Chromatography B, Plos ONE, Proteomes, International Journal of Molecular Science, Biotech, Electrophoresis, and others. He is also Associate Editor of Biotech.",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",slug:"simona-viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",biography:"Simona Viglio is an Associate Professor of Biochemistry at the Department of Molecular Medicine at the University of Pavia. She has been working since 1995 on the determination of proteolytic enzymes involved in the degradation process of connective tissue matrix and on the identification of biological markers of lung diseases. 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He is also a faculty member in the Molecular Oncology Program. He obtained his MSc and Ph.D. at Oregon State University and Texas Tech University, respectively. He pursued his postdoctoral studies at Rutgers University Medical School and the National Institutes of Health (NIH/NIDDK), USA. His research focuses on biochemistry, biophysics, genetics, molecular biology, and molecular medicine with specialization in the fields of drug design, protein structure-function, protein folding, prions, microRNA, pseudogenes, molecular cancer, epigenetics, metabolites, proteomics, genomics, protein expression, and characterization by spectroscopic and calorimetric methods.",institutionString:"University of Health Sciences",institution:null},{id:"180528",title:"Dr.",name:"Hiroyuki",middleName:null,surname:"Kagechika",slug:"hiroyuki-kagechika",fullName:"Hiroyuki Kagechika",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180528/images/system/180528.jpg",biography:"Hiroyuki Kagechika received his bachelor’s degree and Ph.D. in Pharmaceutical Sciences from the University of Tokyo, Japan, where he served as an associate professor until 2004. He is currently a professor at the Institute of Biomaterials and Bioengineering (IBB), Tokyo Medical and Dental University (TMDU). From 2010 to 2012, he was the dean of the Graduate School of Biomedical Science. Since 2012, he has served as the vice dean of the Graduate School of Medical and Dental Sciences. He has been the director of the IBB since 2020. Dr. Kagechika’s major research interests are the medicinal chemistry of retinoids, vitamins D/K, and nuclear receptors. He has developed various compounds including a drug for acute promyelocytic leukemia.",institutionString:"Tokyo Medical and Dental University",institution:{name:"Tokyo Medical and Dental University",country:{name:"Japan"}}},{id:"40482",title:null,name:"Rizwan",middleName:null,surname:"Ahmad",slug:"rizwan-ahmad",fullName:"Rizwan Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/40482/images/system/40482.jpeg",biography:"Dr. Rizwan Ahmad is a University Professor and Coordinator, Quality and Development, College of Medicine, Imam Abdulrahman bin Faisal University, Saudi Arabia. Previously, he was Associate Professor of Human Function, Oman Medical College, Oman, and SBS University, Dehradun. Dr. Ahmad completed his education at Aligarh Muslim University, Aligarh. He has published several articles in peer-reviewed journals, chapters, and edited books. His area of specialization is free radical biochemistry and autoimmune diseases.",institutionString:"Imam Abdulrahman Bin Faisal University",institution:{name:"Imam Abdulrahman Bin Faisal University",country:{name:"Saudi Arabia"}}},{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/41865/images/system/41865.jpg",biography:"Farid A. Badria, Ph.D., is the recipient of several awards, including The World Academy of Sciences (TWAS) Prize for Public Understanding of Science; the World Intellectual Property Organization (WIPO) Gold Medal for best invention; Outstanding Arab Scholar, Kuwait; and the Khwarizmi International Award, Iran. He has 250 publications, 12 books, 20 patents, and several marketed pharmaceutical products to his credit. He continues to lead research projects on developing new therapies for liver, skin disorders, and cancer. Dr. Badria was listed among the world’s top 2% of scientists in medicinal and biomolecular chemistry in 2019 and 2020. He is a member of the Arab Development Fund, Kuwait; International Cell Research Organization–United Nations Educational, Scientific and Cultural Organization (ICRO–UNESCO), Chile; and UNESCO Biotechnology France",institutionString:"Mansoura University",institution:{name:"Mansoura University",country:{name:"Egypt"}}},{id:"329385",title:"Dr.",name:"Rajesh K.",middleName:"Kumar",surname:"Singh",slug:"rajesh-k.-singh",fullName:"Rajesh K. Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329385/images/system/329385.png",biography:"Dr. Singh received a BPharm (2003) and MPharm (2005) from Panjab University, Chandigarh, India, and a Ph.D. (2013) from Punjab Technical University (PTU), Jalandhar, India. He has more than sixteen years of teaching experience and has supervised numerous postgraduate and Ph.D. students. He has to his credit more than seventy papers in SCI- and SCOPUS-indexed journals, fifty-five conference proceedings, four books, six Best Paper Awards, and five projects from different government agencies. He is currently an editorial board member of eight international journals and a reviewer for more than fifty scientific journals. He received Top Reviewer and Excellent Peer Reviewer Awards from Publons in 2016 and 2017, respectively. He is also on the panel of The International Reviewer for reviewing research proposals for grants from the Royal Society. He also serves as a Publons Academy mentor and Bentham brand ambassador.",institutionString:"Punjab Technical University",institution:{name:"Punjab Technical University",country:{name:"India"}}},{id:"142388",title:"Dr.",name:"Thiago",middleName:"Gomes",surname:"Gomes Heck",slug:"thiago-gomes-heck",fullName:"Thiago Gomes Heck",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/142388/images/7259_n.jpg",biography:null,institutionString:null,institution:{name:"Universidade Regional do Noroeste do Estado do Rio Grande do Sul",country:{name:"Brazil"}}},{id:"336273",title:"Assistant Prof.",name:"Janja",middleName:null,surname:"Zupan",slug:"janja-zupan",fullName:"Janja Zupan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/336273/images/14853_n.jpeg",biography:"Janja Zupan graduated in 2005 at the Department of Clinical Biochemistry (superviser prof. dr. Janja Marc) in the field of genetics of osteoporosis. Since November 2009 she is working as a Teaching Assistant at the Faculty of Pharmacy, Department of Clinical Biochemistry. In 2011 she completed part of her research and PhD work at Institute of Genetics and Molecular Medicine, University of Edinburgh. She finished her PhD entitled The influence of the proinflammatory cytokines on the RANK/RANKL/OPG in bone tissue of osteoporotic and osteoarthritic patients in 2012. From 2014-2016 she worked at the Institute of Biomedical Sciences, University of Aberdeen as a postdoctoral research fellow on UK Arthritis research project where she gained knowledge in mesenchymal stem cells and regenerative medicine. She returned back to University of Ljubljana, Faculty of Pharmacy in 2016. She is currently leading project entitled Mesenchymal stem cells-the keepers of tissue endogenous regenerative capacity facing up to aging of the musculoskeletal system funded by Slovenian Research Agency.",institutionString:null,institution:{name:"University of Ljubljana",country:{name:"Slovenia"}}},{id:"357453",title:"Dr.",name:"Radheshyam",middleName:null,surname:"Maurya",slug:"radheshyam-maurya",fullName:"Radheshyam Maurya",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/357453/images/16535_n.jpg",biography:null,institutionString:null,institution:{name:"University of Hyderabad",country:{name:"India"}}},{id:"311457",title:"Dr.",name:"Júlia",middleName:null,surname:"Scherer Santos",slug:"julia-scherer-santos",fullName:"Júlia Scherer Santos",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/311457/images/system/311457.jpg",biography:"Dr. Júlia Scherer Santos works in the areas of cosmetology, nanotechnology, pharmaceutical technology, beauty, and aesthetics. Dr. Santos also has experience as a professor of graduate courses. Graduated in Pharmacy, specialization in Cosmetology and Cosmeceuticals applied to aesthetics, specialization in Aesthetic and Cosmetic Health, and a doctorate in Pharmaceutical Nanotechnology. Teaching experience in Pharmacy and Aesthetics and Cosmetics courses. She works mainly on the following subjects: nanotechnology, cosmetology, pharmaceutical technology, aesthetics.",institutionString:"Universidade Federal de Juiz de Fora",institution:{name:"Universidade Federal de Juiz de Fora",country:{name:"Brazil"}}},{id:"219081",title:"Dr.",name:"Abdulsamed",middleName:null,surname:"Kükürt",slug:"abdulsamed-kukurt",fullName:"Abdulsamed Kükürt",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRNVJQA4/Profile_Picture_2022-03-07T13:23:04.png",biography:"Dr. Kükürt graduated from Uludağ University in Turkey. He started his academic career as a Research Assistant in the Department of Biochemistry at Kafkas University. In 2019, he completed his Ph.D. program in the Department of Biochemistry at the Institute of Health Sciences. He is currently working at the Department of Biochemistry, Kafkas University. He has 27 published research articles in academic journals, 11 book chapters, and 37 papers. He took part in 10 academic projects. He served as a reviewer for many articles. He still serves as a member of the review board in many academic journals.",institutionString:null,institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"178366",title:"Associate Prof.",name:"Volkan",middleName:null,surname:"Gelen",slug:"volkan-gelen",fullName:"Volkan Gelen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178366/images/system/178366.jpg",biography:"Volkan Gelen is a Physiology specialist who received his veterinary degree from Kafkas University in 2011. Between 2011-2015, he worked as an assistant at Atatürk University, Faculty of Veterinary Medicine, Department of Physiology. In 2016, he joined Kafkas University, Faculty of Veterinary Medicine, Department of Physiology as an assistant professor. Dr. Gelen has been engaged in various academic activities at Kafkas University since 2016. There he completed 5 projects and has 3 ongoing projects. He has 60 articles published in scientific journals and 20 poster presentations in scientific congresses. His research interests include physiology, endocrine system, cancer, diabetes, cardiovascular system diseases, and isolated organ bath system studies.",institutionString:"Kafkas University",institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"418963",title:"Dr.",name:"Augustine Ododo",middleName:"Augustine",surname:"Osagie",slug:"augustine-ododo-osagie",fullName:"Augustine Ododo Osagie",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/418963/images/16900_n.jpg",biography:"Born into the family of Osagie, a prince of the Benin Kingdom. I am currently an academic in the Department of Medical Biochemistry, University of Benin. Part of the duties are to teach undergraduate students and conduct academic research.",institutionString:null,institution:{name:"University of Benin",country:{name:"Nigeria"}}},{id:"192992",title:"Prof.",name:"Shagufta",middleName:null,surname:"Perveen",slug:"shagufta-perveen",fullName:"Shagufta Perveen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/192992/images/system/192992.png",biography:"Prof. Shagufta Perveen is a Distinguish Professor in the Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. Dr. Perveen has acted as the principal investigator of major research projects funded by the research unit of King Saud University. She has more than ninety original research papers in peer-reviewed journals of international repute to her credit. She is a fellow member of the Royal Society of Chemistry UK and the American Chemical Society of the United States.",institutionString:"King Saud University",institution:{name:"King Saud University",country:{name:"Saudi Arabia"}}},{id:"49848",title:"Dr.",name:"Wen-Long",middleName:null,surname:"Hu",slug:"wen-long-hu",fullName:"Wen-Long Hu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49848/images/system/49848.jpg",biography:"Wen-Long Hu is Chief of the Division of Acupuncture, Department of Chinese Medicine at Kaohsiung Chang Gung Memorial Hospital, as well as an adjunct associate professor at Fooyin University and Kaohsiung Medical University. Wen-Long is President of Taiwan Traditional Chinese Medicine Medical Association. He has 28 years of experience in clinical practice in laser acupuncture therapy and 34 years in acupuncture. He is an invited speaker for lectures and workshops in laser acupuncture at many symposiums held by medical associations. He owns the patent for herbal preparation and producing, and for the supercritical fluid-treated needle. Dr. Hu has published three books, 12 book chapters, and more than 30 papers in reputed journals, besides serving as an editorial board member of repute.",institutionString:"Kaohsiung Chang Gung Memorial Hospital",institution:{name:"Kaohsiung Chang Gung Memorial Hospital",country:{name:"Taiwan"}}},{id:"298472",title:"Prof.",name:"Andrey V.",middleName:null,surname:"Grechko",slug:"andrey-v.-grechko",fullName:"Andrey V. Grechko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/298472/images/system/298472.png",biography:"Andrey Vyacheslavovich Grechko, Ph.D., Professor, is a Corresponding Member of the Russian Academy of Sciences. He graduated from the Semashko Moscow Medical Institute (Semashko National Research Institute of Public Health) with a degree in Medicine (1998), the Clinical Department of Dermatovenerology (2000), and received a second higher education in Psychology (2009). Professor A.V. Grechko held the position of Сhief Physician of the Central Clinical Hospital in Moscow. He worked as a professor at the faculty and was engaged in scientific research at the Medical University. Starting in 2013, he has been the initiator of the creation of the Federal Scientific and Clinical Center for Intensive Care and Rehabilitology, Moscow, Russian Federation, where he also serves as Director since 2015. He has many years of experience in research and teaching in various fields of medicine, is an author/co-author of more than 200 scientific publications, 13 patents, 15 medical books/chapters, including Chapter in Book «Metabolomics», IntechOpen, 2020 «Metabolomic Discovery of Microbiota Dysfunction as the Cause of Pathology».",institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"199461",title:"Prof.",name:"Natalia V.",middleName:null,surname:"Beloborodova",slug:"natalia-v.-beloborodova",fullName:"Natalia V. Beloborodova",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/199461/images/system/199461.jpg",biography:'Natalia Vladimirovna Beloborodova was educated at the Pirogov Russian National Research Medical University, with a degree in pediatrics in 1980, a Ph.D. in 1987, and a specialization in Clinical Microbiology from First Moscow State Medical University in 2004. She has been a Professor since 1996. Currently, she is the Head of the Laboratory of Metabolism, a division of the Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russian Federation. N.V. Beloborodova has many years of clinical experience in the field of intensive care and surgery. She studies infectious complications and sepsis. She initiated a series of interdisciplinary clinical and experimental studies based on the concept of integrating human metabolism and its microbiota. Her scientific achievements are widely known: she is the recipient of the Marie E. Coates Award \\"Best lecturer-scientist\\" Gustafsson Fund, Karolinska Institutes, Stockholm, Sweden, and the International Sepsis Forum Award, Pasteur Institute, Paris, France (2014), etc. Professor N.V. Beloborodova wrote 210 papers, five books, 10 chapters and has edited four books.',institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"354260",title:"Ph.D.",name:"Tércio Elyan",middleName:"Azevedo",surname:"Azevedo Martins",slug:"tercio-elyan-azevedo-martins",fullName:"Tércio Elyan Azevedo Martins",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/354260/images/16241_n.jpg",biography:"Graduated in Pharmacy from the Federal University of Ceará with the modality in Industrial Pharmacy, Specialist in Production and Control of Medicines from the University of São Paulo (USP), Master in Pharmaceuticals and Medicines from the University of São Paulo (USP) and Doctor of Science in the program of Pharmaceuticals and Medicines by the University of São Paulo. Professor at Universidade Paulista (UNIP) in the areas of chemistry, cosmetology and trichology. Assistant Coordinator of the Higher Course in Aesthetic and Cosmetic Technology at Universidade Paulista Campus Chácara Santo Antônio. Experience in the Pharmacy area, with emphasis on Pharmacotechnics, Pharmaceutical Technology, Research and Development of Cosmetics, acting mainly on topics such as cosmetology, antioxidant activity, aesthetics, photoprotection, cyclodextrin and thermal analysis.",institutionString:null,institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"334285",title:"Ph.D. Student",name:"Sameer",middleName:"Kumar",surname:"Jagirdar",slug:"sameer-jagirdar",fullName:"Sameer Jagirdar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334285/images/14691_n.jpg",biography:"I\\'m a graduate student at the center for biosystems science and engineering at the Indian Institute of Science, Bangalore, India. I am interested in studying host-pathogen interactions at the biomaterial interface.",institutionString:null,institution:{name:"Indian Institute of Science Bangalore",country:{name:"India"}}},{id:"329795",title:"Dr.",name:"Mohd Aftab",middleName:"Aftab",surname:"Siddiqui",slug:"mohd-aftab-siddiqui",fullName:"Mohd Aftab Siddiqui",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329795/images/15648_n.jpg",biography:"Dr. Mohd Aftab Siddiqui is currently working as Assistant Professor in the Faculty of Pharmacy, Integral University, Lucknow for the last 6 years. He has completed his Doctor in Philosophy (Pharmacology) in 2020 from Integral University, Lucknow. He completed his Bachelor in Pharmacy in 2013 and Master in Pharmacy (Pharmacology) in 2015 from Integral University, Lucknow. He is the gold medalist in Bachelor and Master degree. He qualified GPAT -2013, GPAT -2014, and GPAT 2015. His area of research is Pharmacological screening of herbal drugs/ natural products in liver and cardiac diseases. He has guided many M. Pharm. research projects. He has many national and international publications.",institutionString:"Integral University",institution:null},{id:"255360",title:"Dr.",name:"Usama",middleName:null,surname:"Ahmad",slug:"usama-ahmad",fullName:"Usama Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255360/images/system/255360.png",biography:"Dr. Usama Ahmad holds a specialization in Pharmaceutics from Amity University, Lucknow, India. He received his Ph.D. degree from Integral University. Currently, he’s working as an Assistant Professor of Pharmaceutics in the Faculty of Pharmacy, Integral University. From 2013 to 2014 he worked on a research project funded by SERB-DST, Government of India. He has a rich publication record with more than 32 original articles published in reputed journals, 3 edited books, 5 book chapters, and a number of scientific articles published in ‘Ingredients South Asia Magazine’ and ‘QualPharma Magazine’. He is a member of the American Association for Cancer Research, International Association for the Study of Lung Cancer, and the British Society for Nanomedicine. Dr. Ahmad’s research focus is on the development of nanoformulations to facilitate the delivery of drugs that aim to provide practical solutions to current healthcare problems.",institutionString:"Integral University",institution:{name:"Integral University",country:{name:"India"}}},{id:"30568",title:"Prof.",name:"Madhu",middleName:null,surname:"Khullar",slug:"madhu-khullar",fullName:"Madhu Khullar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/30568/images/system/30568.jpg",biography:"Dr. Madhu Khullar is a Professor of Experimental Medicine and Biotechnology at the Post Graduate Institute of Medical Education and Research, Chandigarh, India. She completed her Post Doctorate in hypertension research at the Henry Ford Hospital, Detroit, USA in 1985. She is an editor and reviewer of several international journals, and a fellow and member of several cardiovascular research societies. Dr. Khullar has a keen research interest in genetics of hypertension, and is currently studying pharmacogenetics of hypertension.",institutionString:"Post Graduate Institute of Medical Education and Research",institution:{name:"Post Graduate Institute of Medical Education and Research",country:{name:"India"}}},{id:"223233",title:"Prof.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/223233/images/system/223233.png",biography:"Xianquan Zhan received his MD and Ph.D. in Preventive Medicine at West China University of Medical Sciences. He received his post-doctoral training in oncology and cancer proteomics at the Central South University, China, and the University of Tennessee Health Science Center (UTHSC), USA. He worked at UTHSC and the Cleveland Clinic in 2001–2012 and achieved the rank of associate professor at UTHSC. Currently, he is a full professor at Central South University and Shandong First Medical University, and an advisor to MS/PhD students and postdoctoral fellows. He is also a fellow of the Royal Society of Medicine and European Association for Predictive Preventive Personalized Medicine (EPMA), a national representative of EPMA, and a member of the American Society of Clinical Oncology (ASCO) and the American Association for the Advancement of Sciences (AAAS). He is also the editor in chief of International Journal of Chronic Diseases & Therapy, an associate editor of EPMA Journal, Frontiers in Endocrinology, and BMC Medical Genomics, and a guest editor of Mass Spectrometry Reviews, Frontiers in Endocrinology, EPMA Journal, and Oxidative Medicine and Cellular Longevity. He has published more than 148 articles, 28 book chapters, 6 books, and 2 US patents in the field of clinical proteomics and biomarkers.",institutionString:"Shandong First Medical University",institution:{name:"Affiliated Hospital of Shandong Academy of Medical Sciences",country:{name:"China"}}},{id:"297507",title:"Dr.",name:"Charles",middleName:"Elias",surname:"Assmann",slug:"charles-assmann",fullName:"Charles Assmann",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/297507/images/system/297507.jpg",biography:"Charles Elias Assmann is a biologist from Federal University of Santa Maria (UFSM, Brazil), who spent some time abroad at the Ludwig-Maximilians-Universität München (LMU, Germany). He has Masters Degree in Biochemistry (UFSM), and is currently a PhD student at Biochemistry at the Department of Biochemistry and Molecular Biology of the UFSM. His areas of expertise include: Biochemistry, Molecular Biology, Enzymology, Genetics and Toxicology. He is currently working on the following subjects: Aluminium toxicity, Neuroinflammation, Oxidative stress and Purinergic system. Since 2011 he has presented more than 80 abstracts in scientific proceedings of national and international meetings. Since 2014, he has published more than 20 peer reviewed papers (including 4 reviews, 3 in Portuguese) and 2 book chapters. He has also been a reviewer of international journals and ad hoc reviewer of scientific committees from Brazilian Universities.",institutionString:"Universidade Federal de Santa Maria",institution:{name:"Universidade Federal de Santa Maria",country:{name:"Brazil"}}},{id:"217850",title:"Dr.",name:"Margarete Dulce",middleName:null,surname:"Bagatini",slug:"margarete-dulce-bagatini",fullName:"Margarete Dulce Bagatini",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/217850/images/system/217850.jpeg",biography:"Dr. Margarete Dulce Bagatini is an associate professor at the Federal University of Fronteira Sul/Brazil. She has a degree in Pharmacy and a PhD in Biological Sciences: Toxicological Biochemistry. She is a member of the UFFS Research Advisory Committee\nand a member of the Biovitta Research Institute. She is currently:\nthe leader of the research group: Biological and Clinical Studies\nin Human Pathologies, professor of postgraduate program in\nBiochemistry at UFSC and postgraduate program in Science and Food Technology at\nUFFS. She has experience in the area of pharmacy and clinical analysis, acting mainly\non the following topics: oxidative stress, the purinergic system and human pathologies, being a reviewer of several international journals and books.",institutionString:"Universidade Federal da Fronteira Sul",institution:{name:"Universidade Federal da Fronteira Sul",country:{name:"Brazil"}}},{id:"226275",title:"Ph.D.",name:"Metin",middleName:null,surname:"Budak",slug:"metin-budak",fullName:"Metin Budak",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/226275/images/system/226275.jfif",biography:"Metin Budak, MSc, PhD is an Assistant Professor at Trakya University, Faculty of Medicine. He has been Head of the Molecular Research Lab at Prof. Mirko Tos Ear and Hearing Research Center since 2018. His specializations are biophysics, epigenetics, genetics, and methylation mechanisms. He has published around 25 peer-reviewed papers, 2 book chapters, and 28 abstracts. He is a member of the Clinical Research Ethics Committee and Quantification and Consideration Committee of Medicine Faculty. His research area is the role of methylation during gene transcription, chromatin packages DNA within the cell and DNA repair, replication, recombination, and gene transcription. His research focuses on how the cell overcomes chromatin structure and methylation to allow access to the underlying DNA and enable normal cellular function.",institutionString:"Trakya University",institution:{name:"Trakya University",country:{name:"Turkey"}}},{id:"243049",title:"Dr.",name:"Anca",middleName:null,surname:"Pantea Stoian",slug:"anca-pantea-stoian",fullName:"Anca Pantea Stoian",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243049/images/system/243049.jpg",biography:"Anca Pantea Stoian is a specialist in diabetes, nutrition, and metabolic diseases as well as health food hygiene. She also has competency in general ultrasonography.\n\nShe is an associate professor in the Diabetes, Nutrition and Metabolic Diseases Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. She has been chief of the Hygiene Department, Faculty of Dentistry, at the same university since 2019. Her interests include micro and macrovascular complications in diabetes and new therapies. Her research activities focus on nutritional intervention in chronic pathology, as well as cardio-renal-metabolic risk assessment, and diabetes in cancer. She is currently engaged in developing new therapies and technological tools for screening, prevention, and patient education in diabetes. \n\nShe is a member of the European Association for the Study of Diabetes, Cardiometabolic Academy, CEDA, Romanian Society of Diabetes, Nutrition and Metabolic Diseases, Romanian Diabetes Federation, and Association for Renal Metabolic and Nutrition studies. She has authored or co-authored 160 papers in national and international peer-reviewed journals.",institutionString:null,institution:{name:"Carol Davila University of Medicine and Pharmacy",country:{name:"Romania"}}},{id:"279792",title:"Dr.",name:"João",middleName:null,surname:"Cotas",slug:"joao-cotas",fullName:"João Cotas",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/279792/images/system/279792.jpg",biography:"Graduate and master in Biology from the University of Coimbra.\n\nI am a research fellow at the Macroalgae Laboratory Unit, in the MARE-UC – Marine and Environmental Sciences Centre of the University of Coimbra. My principal function is the collection, extraction and purification of macroalgae compounds, chemical and bioactive characterization of the compounds and algae extracts and development of new methodologies in marine biotechnology area. \nI am associated in two projects: one consists on discovery of natural compounds for oncobiology. The other project is the about the natural compounds/products for agricultural area.\n\nPublications:\nCotas, J.; Figueirinha, A.; Pereira, L.; Batista, T. 2018. An analysis of the effects of salinity on Fucus ceranoides (Ochrophyta, Phaeophyceae), in the Mondego River (Portugal). Journal of Oceanology and Limnology. in press. DOI: 10.1007/s00343-019-8111-3",institutionString:"Faculty of Sciences and Technology of University of Coimbra",institution:null},{id:"279788",title:"Dr.",name:"Leonel",middleName:null,surname:"Pereira",slug:"leonel-pereira",fullName:"Leonel Pereira",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/279788/images/system/279788.jpg",biography:"Leonel Pereira has an undergraduate degree in Biology, a Ph.D. in Biology (specialty in Cell Biology), and a Habilitation degree in Biosciences (specialization in Biotechnology) from the Faculty of Science and Technology, University of Coimbra, Portugal, where he is currently a professor. In addition to teaching at this university, he is an integrated researcher at the Marine and Environmental Sciences Center (MARE), Portugal. His interests include marine biodiversity (algae), marine biotechnology (algae bioactive compounds), and marine ecology (environmental assessment). Since 2008, he has been the author and editor of the electronic publication MACOI – Portuguese Seaweeds Website (www.seaweeds.uc.pt). He is also a member of the editorial boards of several scientific journals. Dr. Pereira has edited or authored more than 20 books, 100 journal articles, and 45 book chapters. He has given more than 100 lectures and oral communications at various national and international scientific events. He is the coordinator of several national and international research projects. In 1998, he received the Francisco de Holanda Award (Honorable Mention) and, more recently, the Mar Rei D. Carlos award (18th edition). He is also a winner of the 2016 CHOICE Award for an outstanding academic title for his book Edible Seaweeds of the World. In 2020, Dr. Pereira received an Honorable Mention for the Impact of International Publications from the Web of Science",institutionString:"University of Coimbra",institution:{name:"University of Coimbra",country:{name:"Portugal"}}},{id:"61946",title:"Dr.",name:"Carol",middleName:null,surname:"Bernstein",slug:"carol-bernstein",fullName:"Carol Bernstein",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/61946/images/system/61946.jpg",biography:"Carol Bernstein received her PhD in Genetics from the University of California (Davis). She was a faculty member at the University of Arizona College of Medicine for 43 years, retiring in 2011. Her research interests focus on DNA damage and its underlying role in sex, aging and in the early steps of initiation and progression to cancer. In her research, she had used organisms including bacteriophage T4, Neurospora crassa, Schizosaccharomyces pombe and mice, as well as human cells and tissues. She authored or co-authored more than 140 scientific publications, including articles in major peer reviewed journals, book chapters, invited reviews and one book.",institutionString:"University of Arizona",institution:{name:"University of Arizona",country:{name:"United States of America"}}},{id:"182258",title:"Dr.",name:"Ademar",middleName:"Pereira",surname:"Serra",slug:"ademar-serra",fullName:"Ademar Serra",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/182258/images/system/182258.jpeg",biography:"Dr. Serra studied Agronomy on Universidade Federal de Mato Grosso do Sul (UFMS) (2005). He received master degree in Agronomy, Crop Science (Soil fertility and plant nutrition) (2007) by Universidade Federal da Grande Dourados (UFGD), and PhD in agronomy (Soil fertility and plant nutrition) (2011) from Universidade Federal da Grande Dourados / Escola Superior de Agricultura Luiz de Queiroz (UFGD/ESALQ-USP). Dr. Serra is currently working at Brazilian Agricultural Research Corporation (EMBRAPA). His research focus is on mineral nutrition of plants, crop science and soil science. Dr. Serra\\'s current projects are soil organic matter, soil phosphorus fractions, compositional nutrient diagnosis (CND) and isometric log ratio (ilr) transformation in compositional data analysis.",institutionString:"Brazilian Agricultural Research Corporation",institution:{name:"Brazilian Agricultural Research Corporation",country:{name:"Brazil"}}}]}},subseries:{item:{id:"8",type:"subseries",title:"Bioinspired Technology and Biomechanics",keywords:"Bioinspired Systems, Biomechanics, Assistive Technology, Rehabilitation",scope:'Bioinspired technologies take advantage of understanding the actual biological system to provide solutions to problems in several areas. Recently, bioinspired systems have been successfully employing biomechanics to develop and improve assistive technology and rehabilitation devices. The research topic "Bioinspired Technology and Biomechanics" welcomes studies reporting recent advances in bioinspired technologies that contribute to individuals\' health, inclusion, and rehabilitation. Possible contributions can address (but are not limited to) the following research topics: Bioinspired design and control of exoskeletons, orthoses, and prostheses; Experimental evaluation of the effect of assistive devices (e.g., influence on gait, balance, and neuromuscular system); Bioinspired technologies for rehabilitation, including clinical studies reporting evaluations; Application of neuromuscular and biomechanical models to the development of bioinspired technology.',coverUrl:"https://cdn.intechopen.com/series_topics/covers/8.jpg",hasOnlineFirst:!1,hasPublishedBooks:!0,annualVolume:11404,editor:{id:"144937",title:"Prof.",name:"Adriano",middleName:"De Oliveira",surname:"Andrade",slug:"adriano-andrade",fullName:"Adriano Andrade",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRC8QQAW/Profile_Picture_1625219101815",biography:"Dr. Adriano de Oliveira Andrade graduated in Electrical Engineering at the Federal University of Goiás (Brazil) in 1997. He received his MSc and PhD in Biomedical Engineering respectively from the Federal University of Uberlândia (UFU, Brazil) in 2000 and from the University of Reading (UK) in 2005. He completed a one-year Post-Doctoral Fellowship awarded by the DFAIT (Foreign Affairs and International Trade Canada) at the Institute of Biomedical Engineering of the University of New Brunswick (Canada) in 2010. Currently, he is Professor in the Faculty of Electrical Engineering (UFU). He has authored and co-authored more than 200 peer-reviewed publications in Biomedical Engineering. He has been a researcher of The National Council for Scientific and Technological Development (CNPq-Brazil) since 2009. He has served as an ad-hoc consultant for CNPq, CAPES (Coordination for the Improvement of Higher Education Personnel), FINEP (Brazilian Innovation Agency), and other funding bodies on several occasions. He was the Secretary of the Brazilian Society of Biomedical Engineering (SBEB) from 2015 to 2016, President of SBEB (2017-2018) and Vice-President of SBEB (2019-2020). He was the head of the undergraduate program in Biomedical Engineering of the Federal University of Uberlândia (2015 - June/2019) and the head of the Centre for Innovation and Technology Assessment in Health (NIATS/UFU) since 2010. He is the head of the Postgraduate Program in Biomedical Engineering (UFU, July/2019 - to date). He was the secretary of the Parkinson's Disease Association of Uberlândia (2018-2019). Dr. Andrade's primary area of research is focused towards getting information from the neuromuscular system to understand its strategies of organization, adaptation and controlling in the context of motor neuron diseases. His research interests include Biomedical Signal Processing and Modelling, Assistive Technology, Rehabilitation Engineering, Neuroengineering and Parkinson's Disease.",institutionString:null,institution:{name:"Federal University of Uberlândia",institutionURL:null,country:{name:"Brazil"}}},editorTwo:null,editorThree:null,series:{id:"7",title:"Biomedical Engineering",doi:"10.5772/intechopen.71985",issn:"2631-5343"},editorialBoard:[{id:"49517",title:"Prof.",name:"Hitoshi",middleName:null,surname:"Tsunashima",slug:"hitoshi-tsunashima",fullName:"Hitoshi Tsunashima",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYTP4QAO/Profile_Picture_1625819726528",institutionString:null,institution:{name:"Nihon University",institutionURL:null,country:{name:"Japan"}}},{id:"425354",title:"Dr.",name:"Marcus",middleName:"Fraga",surname:"Vieira",slug:"marcus-vieira",fullName:"Marcus Vieira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003BJSgIQAX/Profile_Picture_1627904687309",institutionString:null,institution:{name:"Universidade Federal de Goiás",institutionURL:null,country:{name:"Brazil"}}},{id:"196746",title:"Dr.",name:"Ramana",middleName:null,surname:"Vinjamuri",slug:"ramana-vinjamuri",fullName:"Ramana Vinjamuri",profilePictureURL:"https://mts.intechopen.com/storage/users/196746/images/system/196746.jpeg",institutionString:"University of Maryland, Baltimore County",institution:{name:"University of Maryland, Baltimore County",institutionURL:null,country:{name:"United States of America"}}}]},onlineFirstChapters:{paginationCount:1,paginationItems:[{id:"81644",title:"Perspective Chapter: Ethics of Using Placebo Controlled Trials for Covid-19 Vaccine Development in Vulnerable Populations",doi:"10.5772/intechopen.104776",signatures:"Lesley Burgess, Jurie Jordaan and Matthew Wilson",slug:"perspective-chapter-ethics-of-using-placebo-controlled-trials-for-covid-19-vaccine-development-in-vu",totalDownloads:9,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"SARS-CoV-2 Variants - Two Years After",coverURL:"https://cdn.intechopen.com/books/images_new/11573.jpg",subseries:{id:"6",title:"Viral Infectious Diseases"}}}]},publishedBooks:{paginationCount:0,paginationItems:[]},testimonialsList:[{id:"8",text:"I work with IntechOpen for a number of reasons: their professionalism, their mission in support of Open Access publishing, and the quality of their peer-reviewed publications, but also because they believe in equality.",author:{id:"202192",name:"Catrin",surname:"Rutland",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",slug:"catrin-rutland",institution:{id:"134",name:"University of Nottingham",country:{id:null,name:"United Kingdom"}}}},{id:"27",text:"The opportunity to work with a prestigious publisher allows for the possibility to collaborate with more research groups interested in animal nutrition, leading to the development of new feeding strategies and food valuation while being more sustainable with the environment, allowing more readers to learn about the subject.",author:{id:"175967",name:"Manuel",surname:"Gonzalez Ronquillo",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/175967/images/system/175967.png",slug:"manuel-gonzalez-ronquillo",institution:{id:"6221",name:"Universidad Autónoma del Estado de México",country:{id:null,name:"Mexico"}}}},{id:"18",text:"It was great publishing with IntechOpen, the process was straightforward and I had support all along.",author:{id:"71579",name:"Berend",surname:"Olivier",institutionString:"Utrecht University",profilePictureURL:"https://mts.intechopen.com/storage/users/71579/images/system/71579.png",slug:"berend-olivier",institution:{id:"253",name:"Utrecht University",country:{id:null,name:"Netherlands"}}}}]},submityourwork:{pteSeriesList:[],lsSeriesList:[],hsSeriesList:[],sshSeriesList:[],subseriesList:[],annualVolumeBook:{},thematicCollection:[],selectedSeries:null,selectedSubseries:null},seriesLanding:{item:null},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"chapter.detail",path:"/chapters/52541",hash:"",query:{},params:{id:"52541"},fullPath:"/chapters/52541",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()