\r\n\tCell viability is defined as the number of healthy cells in a sample and proliferation of cells is a vital indicator for understanding the mechanisms inaction of certain genes, proteins, and pathways involved in cell survival or death after exposure to toxic agents. The methods used to determine viability are also common for the detection of cell proliferation. A cell viability assay is performed based on the ratio of live and dead cells. This assay is based on an analysis of cell viability in cell culture for evaluating in vitro drug effects in cell-mediated cytotoxicity assays for monitoring cell proliferation. Various methods are involved in performing a cell viability assay, including the dilution method, surface viable count, roll tube technique, nalidixic acid method, fluorogenic dye assay, and the Trypan Blue Cell Viability Assay. The cell viability assays can determine the effect of drug candidates on cells and be used to optimize the cell culture conditions. The parameters that define cell viability can be as diverse as the redox potential of the cell population, the integrity of cell membranes, or the activity of cellular enzymes. \r\n\tCytotoxicity is the degree to which a substance can cause damage to a cell. Cytotoxicity assays measure the ability of cytotoxic compounds to cause cell damage or cell death. Cytotoxicity assays are widely used in fundamental research and drug discovery to screen libraries for toxic compounds. The cell cytotoxicity and proliferation assays are mainly used for drug screening to detect whether the test molecules have effects on cell proliferation or display direct cytotoxic effects. In a cell-based assay, it is important to know how many viable cells are remaining at the end of the experiment. There are a variety of assay methods based on various cell functions such as enzyme activity, cell membrane permeability, cell adherence, ATP production, co-enzyme production, and nucleotide uptake activity. These methods could be classified in to different categories: (I) dye exclusion methods such as trypan blue dye exclusion assay, (II) methods based on metabolic activity, (III) ATP assay, (IV) sulforhodamine B assay, (V) protease viability marker assay, (VI) clonogenic cell survival assay, (VII) DNA synthesis cell proliferation assays and (V) Raman micro-spectroscopy. \r\n\tMedical devices have been widely used in various clinical disciplines and these devices have direct contact with the tissues and cells of the body, they should have good physical and chemical properties as well as good biocompatibility. Biocompatibility testing assesses the compatibility of medical devices with a biological system. It studies the interaction between the device and the various types of living tissues and cells exposed to the device when it comes into contact with patients.
\r\n
\r\n\t \r\n\tThe book will cover original studies, reviews, all aspects of Cell Viability and Cytotoxicity assays, methods, Biocompatibility of studies of biomedical devices, and related topics.
",isbn:"978-1-80356-246-9",printIsbn:"978-1-80356-245-2",pdfIsbn:"978-1-80356-247-6",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!1,isSalesforceBook:!1,hash:"ad664980a1e5007239b6de58fcf0bd9a",bookSignature:"Prof. Sukumaran Anil",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11678.jpg",keywords:"Cytotoxicity, Cytotoxicity Testing, Biocompatibility, ATP Assay, MTT Assay, Cell Viability, DNA Synthesis Cell Proliferation Assays, Raman Micro-Spectroscopy, Trypan Blue Dye Exclusion Assay, Medical Devices, Drugs, Safety Testing",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"February 10th 2022",dateEndSecondStepPublish:"March 10th 2022",dateEndThirdStepPublish:"May 9th 2022",dateEndFourthStepPublish:"July 28th 2022",dateEndFifthStepPublish:"September 26th 2022",remainingDaysToSecondStep:"2 months",secondStepPassed:!0,currentStepOfPublishingProcess:4,editedByType:null,kuFlag:!1,biosketch:"Prof. Anil Sukumaran is currently Senior Consultant and Professor of Periodontics and Implant Dentistry, Hamad Medical Corporation/Qatar University, Doha, Qatar. He received his Ph.D. in 2002 at the University of Hong Kong. In 1995 he was the invited Researcher at the UK Centre for Oral HIV Studies, UMDS Guys Hospital, London. He is the honorary fellow of the International College of Dentists, USA, and Pierre Fauchard Academy, USA.",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"420937",title:"Prof.",name:"Sukumaran",middleName:null,surname:"Anil",slug:"sukumaran-anil",fullName:"Sukumaran Anil",profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"0",institution:null}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"19",title:"Pharmacology, Toxicology and Pharmaceutical Science",slug:"pharmacology-toxicology-and-pharmaceutical-science"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"455410",firstName:"Dajana",lastName:"Jusic",middleName:null,title:"Mrs.",imageUrl:"https://mts.intechopen.com/storage/users/455410/images/20500_n.jpeg",email:"dajana.j@intechopen.com",biography:"As an Author Service Manager my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review, to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. 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1. Introduction
\n
Floods are among the most major climate-related disasters and have resulted in substantial losses including enormous property damage and human casualties [1]. Numbers of casualties and losses could be larger in the future in response to global warming. The biggest challenge lying in rescuing operations is the low efficiency and the high risk of the rescuers, which is also a problem focused on by this work. Unmanned system is one of the solutions that replace people in the rescuing operations.
\n
Unmanned surface vehicles (USVs), also called autonomous surface vehicles (ASVs), are often used to name the vehicles, which can run on the surface autonomously. Surface robot-assisted flood disaster rescue and inspection is a new research direction in the field of robotics. Here are some obvious advantages: (1) the smaller size allows the USVs to access to narrow and small space to get detailed information; (2) remote operation can avoid casualties of the rescuers caused by the unexpected potential dangers. After Hurricane Wilma in 2005, USVs have been used for emergency response by detecting damage to seawalls and piers, locating submerged debris, and determining safe lanes for sea navigation [2]. After the Fukushima nuclear accident in 2011, the United States and Japan have used robots to assess the damage jointly [3].
\n
Also, in 2007, a new Trimaran unmanned surface vehicle (TUSV) as a test-bed to verify the robust motion control strategies has been designed in Shenyang Institute of Automation, Chinese Academy of Sciences (SIA, CAS) [4]. After that, in 2012, a water-jet propulsion USV equipped with different kind of sensors and ground control system has been designed and implemented in SIA to improve the performance of USV [5]. In 2015, to increase the reliability and real time of USV, the software architecture has been designed based on a real-time operating system QNX 6.5.0. Also, the selection of an appropriate platform and associated hardware as well as useful and sufficient sensors, and integrating these two entities has been taken into consideration. Modular design is adopted in the hardware and software structures to improve system scalability. The hardware structure comprises six sub-systems, including the on-board control computer sub-system, power sub-system, communication sub-system, sensor and perception sub-system, ground station sub-system, and execution sub-system. The software structure comprises six modules, the communicator module, GPS-IMU module, protocol module, tracker module, controller module, execute module, and engine module.
\n
In general, the surface environment of flooding disasters, including fixed obstacles, floating obstacles, narrow canals, and the wind/wave/current disturbances, makes the target difficult to be inspected by an USV, because it presents a great limitation in trajectory tracking in complicated surroundings. The primary reason is the difficulty of obtaining accurate and applicable dynamical models. The hydrodynamic mechanism is very complex, and the dynamical model parameters change with Froude number Fr=U/Lg, where U is the operating speed of USV, L is the overall length of USV (the submerged length of USV), and g is the acceleration of gravity [6]. When the Froude number is <0.5, the main fluid forces exerted on USV are the hydrostatic pressure by replacing water with respect to hydrodynamic pressure, called displacement area; when the Froude number is >0.5 but <1, the main fluid forces exerted on USV are hydrostatic and hydrodynamic pressure, called semi-displacement area; when the Froude number is >1, the main forces exerted on USV are hydrodynamic pressure, called planning area. Since the model structure and parameters will change greatly from displacement area to planning area, there is no unified dynamics model of a surface robot.
\n
To approximate the hydrodynamics, we propose an active quasi-linear parameter varying (qLPV) model to approach the dynamics of the USV system. The LPV model concerns linear models whose state-space representations depend on state independent parameters [7]. The qLPV model is obtained by making the varying parameter of the LPV system a function of the state [8]. To accommodate the unstructured model error, the model error is introduced into the qLPV structured model as a complementation, and with the active modeling technique, the model error online estimation is used to improve the modeling accuracy. There are many available algorithms for active model online estimation such as the extended Kalman filter (EKF) [9] and epsilon-support vector regression (ε-SVR) [10]. In this chapter, the Unscented Kalman Filter (UKF) is utilized to obtain the unstructured model error.
\n
Finally, to show the performance of the USV systems and the modeling methods, extensive experiments have been done including rescuing rope throwing by using an automatic pneumatic, rescuing of people, air–surface robots’ cooperation, environment data collection, model parameters identification, communication distance testing, and water sampling in a 2.5 m radius circle.
\n
\n
2. System design of flooding disaster-oriented USV
\n
Although the parts of USVs have been applied in reality, the autonomy of these platforms is still so weak that most of them can only work under the control of operators. This makes them difficult to be used to verify some high-performance autonomous control algorithm. Thus, a new USV system equipped with different kinds of sensors and ground control system is designed and introduced in this chapter.
\n
Modular design is adopted in hardware and software structures, and the corresponding modules will be described in detail. Every hardware module is a separate subsystem which is connected together by waterproof aviation plugs. An automatic pumping system is equipped in the USV to drain water when the water level in the hull exceeds the warning level. Similar to the hardware system, every software module is a separate processor that is connected together by shared memories. Since all processors share a single view of data, the communication between processors can be fast as memory access. When the shared memories have been created, all the processors needed to do is to map the shared memory and initialize the read/write lock of thread in shared memory struct.
\n
2.1. Hardware design
\n
The USV system designed and implemented in SIA, CAS is shown in Figure 1. Its basic parameters are provided in Table 1.
\n
Figure 1.
The USV platform.
\n
\n
\n
\n
\n
\n
\n\n
\n
Length
\n
Width
\n
Height
\n
Max velocity
\n
Payload
\n
\n\n\n
\n
2800 mm
\n
700 mm
\n
370 mm
\n
36 km/h
\n
70 kg
\n
\n\n
Table 1.
Performance parameters of the USV.
\n
The material of USV is fiber-reinforced polymer (FRP) which is a composite that is suitable for structures in corrosive environment and long-span lightweight structures due to its high-strength, light-weight, and anti-corrosive qualities [11].
\n
To improve system scalability, the hardware structure adopts modular design. The hardware structure comprises six sub-systems, including the on-board control computer sub-system, power sub-system, communication sub-system, sensor and perception sub-system, ground station sub-system, and execution sub-system.
\n
2.1.1. On-board control computer sub-system
\n
The on-board control computer sub-system (Figure 2) contains an Advantech computer UNO-2170 with 2X LAN, 4X COM, 1X 32G Compact Flash (CF), and 2X PCM-3780. The Advantech computer UNO-2170 supports QNX Neutrino Real-time Operating System (RTOS) and can be used to record the experimental data in 0.01 s. The PCM-3780 is a general purpose multiple channel counter/timer card for the PC/104 bus. It provides two 16-bit counter channels which can be used to produce the required Pulse Width Modulation (PWM) wave to control the ignition/flame switch servo, steering rudder servo, engine throttle servo, and the selector switch servo. Using the Advantech computer UNO-2170, the GPS-IMU data, and the command data from ground station sub-system can be received though two COM serial ports.
\n
Figure 2.
On-board control computer sub-system.
\n
\n
2.1.2. Power sub-system
\n
The whole on-board control computer sub-system, as well as all sensors, is powered by a 12 V battery jar. Besides, considering the possibility of overvoltage at the time of switching on power, Advantech PCM-3910 DC-DC power supply module is utilized to smooth the output voltage of the battery. Moreover, the engine can generate electricity to recharge the two batteries using a battery isolator to avoid the voltage dropping when the engine is starting. The working time of the USV system is larger than 2 h.
\n
\n
2.1.3. Communication sub-system
\n
The communication sub-system mainly contains a Futaba receiver, two FGR2 900 MHz industrial radios, a wireless router, and an image transmission equipment. The Futaba receiver is used to receive the signal from the Futaba remote controller in emergency case. The industrial radio in ground station sub-system is used to transform command data from ground station sub-system to on-board control sub-system, while the other industrial radio in on-board control computer sub-system is used to transform feedback data from on-board control computer sub-system to ground station sub-system. The maximum communication distance from ground station sub-system to on-board control sub-system is 20 km. The wireless router is used to connect debugging computer with UNO-2170 computer since it is not convenient to use QNX SDP on a QNX Neutrino RTOS system for self-hosted development. The image transmission equipment is used to transfer the video of the IP camera.
\n
\n
2.1.4. Sensor and perception sub-system
\n
The sensor sub-system contains a GPS-IMU system (see Table 2), an IP camera, a sonar, and a LIDAR. The GPS-IMU is used to locate the USV and obtain some inertial states such as attitude, velocity, and acceleration. The IP camera can monitor the environment of USV both in daytime and at night since it integrates infrared and visible light sensing device. Video from the IP camera is compressed based on the standard of H.264 and is transformed into the ground station sub-system through an image transmission equipment. The sonar and LIDAR sensors are also equipped in the USV system to detect the obstacles under and above the surface, respectively.
\n
\n
\n
\n\n
\n
Specification
\n
Value
\n
\n\n\n
\n
Heading accuracy
\n
0.2° (1 σ, base line ≥ 2 m)
\n
\n
\n
Attitude accuracy
\n
0.5° (1 σ)
\n
\n
\n
Position accuracy
\n
2 cm + 1 ppm (CEP)
\n
\n
\n
Speed accuracy
\n
0.1 m/s
\n
\n
\n
Data updating rate
\n
1 Hz/5 Hz/10 Hz/100 Hz
\n
\n
\n
Gyro range
\n
±100°/s (optional ± 300°/s)
\n
\n
\n
Gyro zero offset
\n
±100°/s
\n
\n\n
Table 2.
Specification of GPS-INS (XW-GI5630).
\n
\n
2.1.5. Ground station sub-system
\n
Ground station sub-system (Figure 3) is an important human computer interaction platform for information processing.
\n
Figure 3.
Ground station sub-system.
\n
It is the main controller unit of the USV system except for the on-board control computer sub-system and plays an important role in assisting the operator to monitor the USV’s state real-time. When the USV is in some emergency situations, the operator can take appropriate disposition to ensure the safety of the USV through the state displayed on the ground station sub-system.
\n
The ground station sub-system includes a high-speed computer, two screens (one is data screen, the other is video screen), communication device and two joysticks (control the rudder angle and engine throttle of the USV system, respectively). It allows remote controller operates the USV such as ignition/flame, speed, and course keeping.
\n
\n
2.1.6. Execution sub-system
\n
The execution sub-system (Figure 4) contains four servos: a rudder servo (used to control the rudder angle of USV), a throttle servo (used to control the throttle size), an ignition/flame servo (used to start or stop the USV), and a switch servo (used to select the ground station or the remote controller to control the USV). The four servos receive the control data from the on-board control computer sub-system or remote controller and take corresponding actions.
\n
Figure 4.
Execution sub-system.
\n
\n
\n
2.2. Software design
\n
Modular design is adopted in software structure. The software structure of computer control system is implemented using QNX SDP V6.5.0, a real-time operational system (RTOS), which is known as a real-time, high stable, and good portable OS. The software structure comprises six modules, the communicator module (TCP communicate and data transmit), GPS-IMU module (receive and process GPS-IMU signals), protocol module (parse the received data frame), tracker module (GPS tracking), controller module (including PID controller, ACC controller, and MPC controller), execute module (send PWM wave data to servos), and engine module (get the engine propeller speed) (Figure 5).
\n
Figure 5.
The software structure of USV system.
\n
In execute module, there is an emergency sub-module that is used to stop the engine if no new data from ground station sub-system is received over 120 s. When new data from ground station sub-system are transferred to the on-board control sub-system, the execute module can generate PWM wave data to control the servos again.
\n
In the software architecture, the key module is the controller module, which contains course keeping control, speed control, and GPS tracking control by using the measurements data from GPS-IMU module. The control period is 0.01 s.
\n
\n
\n
3. USV dynamic modeling
\n
Originally, linear models are often used owing to their simple structure, and mainly include first-order Nomoto model [12], first-order sideslip model [13], and linearized speed and steering model [14]. The Nomoto model describes the yaw dynamics between turn rate and the rudder angle input. However, when the USV’s heading undergoes a small perturbation, the sideslip angle is no longer zero. To eliminate this defect in Nomoto model without considering slipping motion, one can incorporate a first-order lag model for sideslip. The sideslip model describes the sway dynamics that relates sideslip angle to turn rate. In addition to sideslip model, the linearized speed model relates the speed increment to throttle increment input. The linearized steering model relates the sideslip velocity and turn rate to rudder angle input. These models are usually effective under the assumptions: (1) the forward speed changes very slowly [15]; (2) the USV is in displacement area [16]. The deficiencies of the linear models are clear: (1) it presents poor performance when describing the details of the ship dynamics [17]; (2) the parameters change greatly for different speeds of the USV. This deteriorates the control performance greatly.
\n
In addition to linear models, there are two kinds of nonlinear models, maneuvring models and sea keeping models. Maneuvring theory assumes that the USV is moving in restricted calm water. Hence, the maneuvring models are derived for USV moving at positive speed U under a zero-frequency wave excitation assumption. The most famous model in maneuvring theory is the Abkowitz model [18] which adopts a nonlinear third-order truncated Taylor series expansion to approach the hydrodynamics at a nominal condition. Sea keeping theory, on the other hand, is the study of motion when there is wave excitation and the craft keeps its heading ψ and its speed U constant [18]. This introduces a dissipative force [19] known as fluid-memory effects. To estimate and identify the hydrodynamic derivatives of these nonlinear models, the forces and torque exerted on the USV need to be accurately measured. Unfortunately, this requires some strict experimental conditions that are often impossible [20].
\n
In this section, we propose an active qLPV model to approach the hydrodynamics of USV. The advantage of the LPV model is that it is significantly simpler to be analyzed and allows the application of many linear control methods. The qLPV model is obtained by making the varying parameter of the LPV system a function of the state.
\n
3.1. Active quasi-LPV modeling
\n
The LPV model usually refers to the linear time-varying models that possess linear model structure but have exogenous variable w(t) dependent system matrix A and input matrix B as shown in Eq. (1) [7]. While qLPV models means that the system matrix A and (or) input matrix B depend (or depends) on some state variable x of the system itself [8], that is, the system as Eq. (1).\n
x˙=A(w(t))x+B(w(t))uE1
\n
x˙=A(w(t),x(t))x+B(w(t),x(t))uE2
\n
That is, qLPV models are some kinds of generation of LPV models. The reason why we select the qLPV model structure to present the USV dynamics is that the nonlinearities of an USV cannot be ignored, especially when the USV is maneuvring with quickly varying velocity and course. Therefore, to denote the strong nonlinearities, the USV system can only be transferred into the qLPV form [21]:\n
v˙=A(v)v+BuE3
\n
where A(v) = M−1N(v); u=T[sinδcosδ]T; B=M−1[0−1xδ100]T.
\n
The function A(v) in Eq. (3) can be denoted as linear combinations of the USV’s velocity, that is,\n
A(v)=M−1(N0+N1|u|+N2|v|+N3r+N4|r|)E4
\n
where\n
\n
\n
The qLPV model structure provides two advantages: (1) its parameters can be identified by some linear algorithm resulting in a nonlinear mathematical model; and (2) mature linear control synthesis schemes can be generalized to obtain adequate performance.
\n
To further eliminate the unstructured model error, the active modeling technique is used to account for the unstructured factors. In the preceding work, we have proposed a control architecture as following Figure 6.
\n
Figure 6.
Active model-based control scheme.
\n
In this architecture, the structured model can be used to design some nominal controller, while the online estimated model error is used to improve the closed loop performance of the nominal controller. To obtain the model error, we first rewrite the system Eq. (3) to follow the state-space form:\n
v˙=A(v)v+Bu+Δvz=v+vmE5
\n
where v is the system state vector; A(v)v + Bu is the structured system dynamics function which is shown in Eqs. (3) and (4); ∆v is the model error; z contains the measurements; and vm contains the measurement noise.
\n
Then, UKF algorithm is used to estimate the model error ∆v using the available measurements. The UKF is an often-used nonlinear Kalman filter owing to its good performance with respect to strong nonlinearities. The main idea of the UKF algorithm is that it uses the unscented transformation (UT) to handle the nonlinear part and compute the influence of the nonlinear function on some stochastic variables. The UT provides an approach for approximating the statistics of a nonlinear transformation through a finite set of “sigma points”:\n
z=f(x)E6
\n
where f is a nonlinear function and x denotes an n × 1 stochastic variable with a mean of x¯ and a covariance of Px.
\n
To calculate the propagation statistics of x through f, that is, the mean z¯ and covariance Pz of the output z, the UT uses the following steps. The complete process is illustrated in Figure 7.
\n
Figure 7.
Unscented transformation.
\n
The normal UKF can be deduced as follows.
\n
UKF-I: Initialization. The measurement noise vector statistics are calculated from the initial measurement:\n
where E[*] denotes the mean (i.e., expectation) of [*].
\n
UKF-II: Sigma points calculation. At the kth time instant, using the kth time instant mean v^ke and covariance Pk, the sigma points are defined using a Gaussian distribution.\n
UKF-IV: Measurements update. Similarly, using the updated state v^k|k−1e and Pk|k−1 in UKF-III, new sigma points ξi,k|k−1e can be calculated to update the measurements.\n
where Qk and Rk are the process and measurement noise covariance, respectively, which are both assumed to be known a priori. The parameter α is usually set within [0.0001, 1].
\n
\n
3.2. Identification results
\n
In this section, we describe the results of two experiments: (1) full state model identification experiment; (2) active modeling enhanced qLPV model experiment. In the final, the results are analyzed and compared.
\n
To quantitatively compare the identification errors, an index function is defined to evaluate the identification errors:\n
To verify the model accuracy for different motion, experiments were conducted using a sine wave rudder angle input as shown in Figure 8. The quantitative comparisons are given in Table 3.
\n
Figure 8.
Sine wave rudder angle: input of the USV.
\n
From these results, one can see that the qLPV model presents better performance for the USV system, especially for surge dynamics, for which the prediction error is <3% (no more than half of that for the two linear models). For sway dynamics, the qLPV model also provides better accuracy, but it is not as good as that for surge dynamics. This means that sway dynamics and yaw dynamics possess stronger nonlinearity since the sway and yaw speed are usually smaller and easily influenced by external disturbances compared to surge dynamics.
\n
\n
\n
\n
\n
\n\n
\n
\n
Linearized
\n
Nomoto with sideslip
\n
qLPV
\n
\n\n\n
\n
(a) Surge dynamics
\n
4.6%
\n
4.6%
\n
2.3%
\n
\n
\n
(b) Sway dynamics
\n
19.7%
\n
17.9%
\n
16.4%
\n
\n
\n
(c) Yaw dynamics
\n
13.7%
\n
13.4%
\n
13.5%
\n
\n\n
Table 3.
Modeling error for sine input.
\n
To further reduce the model mismatch’s influence and improve the estimation accuracy, the active modeling scheme is used. Using an UKF algorithm, the model error of the qLPV structured model is estimated online.
and we use the same data as that of the full state model identification experiment, that is, the throttle was set to 30%, and the rudder angle follows a sine wave with amplitude π/3. The prediction error computed by using Eq. (12) is shown in Table 4. Compared to the results from the qLPV model without active modeling in Table 3, the model accuracy improvement is significant. The active modeling enhanced qLPV model significantly reduces the prediction errors (only one-third of that for the qLPV model). This is intended to make the USV autonomously adaptive to its internal and external uncertainties, that is, to achieve a robust tracking performance for time-varying unknown disturbances in the vehicle dynamics.
\n
\n
\n
\n
\n\n
\n
Surge
\n
Sway
\n
Yaw
\n
\n\n\n
\n
0.8%
\n
4.8%
\n
4.5%
\n
\n\n
Table 4.
Modeling error for active modeling enhanced qLPV model.
\n
\n
\n
4. Application experiments
\n
There are some application experiments to show the performance and application prospect of the USV system, such as rescuing rope throwing, rescuing of people, air–surface robots’ cooperation, environment data collection, and water sampling. In this section, two typical experiments, that is, rescuing experiment and water sampling experiment, are introduced in detail.
\n
4.1. Rescuing experiment
\n
The rescuing throwing experiment is aiming at searching and rescuing the trapped people (Figure 9). When trapped people were detected, the USV’s direction would be adjusted by the ground station sub-system to launch a lifebuoy by using an automatic pneumatic. After the lifebuoy was exposed to water, it would be inflated automatically in 5 s.
\n
Figure 9.
Rescuing experiment. (a) Rescuing rope throwing and (b) rescuing of people.
\n
The launch power is from the high-pressure (30 MPa) gas in pneumatic cylinders. The trigger servo (Figure 10) of the pneumatic is controlled by the PWM wave from the on-board control computer or the remote controller. The farthest distance of dumping is 150 m. Using the kayak carried by the USV, we can achieve trapped people dragging. After the trapped people reached the kayak, the ground station sub-system would send commands to USV to drag the kayak to the safe place automatically.
\n
Figure 10.
Automatic pneumatic.
\n
\n
4.2. Water sampling experiment
\n
The sampling equipment is composed of four sampling bottles, a water pump and some assist mechanical devices (Figure 11).
\n
Figure 11.
Water sampling equipment.
\n
Figure 12.
The minimum turning circle (radius 1.375 m).
\n
Figure 13.
Four water sampling points and distance errors around the sampling points when water sampling.
\n
First, the USV carried two sets of sampling equipment into a designed area (a 2.5 m radius circle around an GPS point). While the USV arriving at the interested point, it started to circle around the interested point at the minimum turning radius by using an GPS point tracking control algorithm (Figure 12). Then, the water pump protruded from the equipment and started drawing water into the bottle (each point for one bottle). After the work was done, the USV would return back automatically by using a course keeping control algorithm.
\n\n
Figure 13 shows the trajectory of USV and the GPS points tracking error at four sampling points when water sampling. In the left figure, the green line represents the trajectory of USV, and the red circles are the 2.5 m radius circles around the designed sampling points. From Figure 13, we can see that the maximum tracking error 1.2 m, far <2.5 m.
\n\n
\n
\n
5. Conclusions
\n
The main concerns in this chapter is to design an real-time flooding disaster-oriented USV and construct a dynamics model for the USV system which is simple enough for model parameters identification and rich enough for motion control.
\n
This work produced three contributions:
\n
A real-time USV system adopting modular design by using different kinds of sensors and ground control system was introduced;
To improve model accuracy, an active qLPV nonlinear model was constructed and identified by considering both the 3-DOF rigid body dynamics and the hydrodynamics;
Extensive experiments were done to show the performance of the hardware and software systems.
\n
\n\n',keywords:"unmanned surface vehicles, quasi-linear parameter varying system, active modeling, unscented Kalman filter",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/51486.pdf",chapterXML:"https://mts.intechopen.com/source/xml/51486.xml",downloadPdfUrl:"/chapter/pdf-download/51486",previewPdfUrl:"/chapter/pdf-preview/51486",totalDownloads:1884,totalViews:187,totalCrossrefCites:2,totalDimensionsCites:2,totalAltmetricsMentions:0,impactScore:1,impactScorePercentile:66,impactScoreQuartile:3,hasAltmetrics:0,dateSubmitted:"November 14th 2015",dateReviewed:"May 19th 2016",datePrePublished:null,datePublished:"September 28th 2016",dateFinished:"June 30th 2016",readingETA:"0",abstract:"Although there exist some unmanned surface platforms, and parts of them have been applied in flooding disaster relief, the autonomy of these platforms is still so weak that most of them can only work under the control of operators. The primary reason is the difficulty of obtaining a dynamical model that is sufficient rich for model-based control and sufficient simple for model parameters identification. This makes them difficult to be used to achieve some high-performance autonomous control, such as robust control with respect to disturbances and unknown dynamics and trajectory tracking control in complicated and dynamical surroundings. In this chapter, a flooding disaster-oriented unmanned surface vehicle (USV) designed and implemented by Shenyang Institute of Automation, Chinese Academy of Sciences (SIA, CAS) is introduced first, including the hardware and software structures. Then, we propose a quasi-linear parameter varying (qLPV) model to approach the dynamics of the USV system. We first apply this to solve a structured modeling problem and then introduce model error to solve an unstructured modeling problem. Subsequently, the qLPV model identification results are analyzed and the superiority compared to two linear models is demonstrated. At last, extensive application experiments, including rescuing rope throwing using an automatic pneumatic and water sampling in a 2.5 m radius circle, are described in detail to show the performance of course keeping control and GPS point tracking control based on the proposed model.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/51486",risUrl:"/chapter/ris/51486",book:{id:"5245",slug:"recent-advances-in-robotic-systems"},signatures:"Junfeng Xiong, Feng Gu, Decai Li, Yuqing He and Jianda Han",authors:[{id:"9884",title:"Dr.",name:"Yuqing",middleName:null,surname:"He",fullName:"Yuqing He",slug:"yuqing-he",email:"heyuqing@sia.cn",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"Anhui University",institutionURL:null,country:{name:"China"}}},{id:"9921",title:"Prof.",name:"Jianda",middleName:null,surname:"Han",fullName:"Jianda Han",slug:"jianda-han",email:"jdhan@sia.cn",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"Shenyang Institute of Automation",institutionURL:null,country:{name:"China"}}},{id:"185358",title:"Dr.",name:"Junfeng",middleName:null,surname:"Xiong",fullName:"Junfeng Xiong",slug:"junfeng-xiong",email:"xjf_whut@qq.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"185359",title:"Dr.",name:"Feng",middleName:null,surname:"Gu",fullName:"Feng Gu",slug:"feng-gu",email:"fenggu@sia.cn",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"185360",title:"Dr.",name:"Decai",middleName:null,surname:"Li",fullName:"Decai Li",slug:"decai-li",email:"Lidecai@sia.cn",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. System design of flooding disaster-oriented USV",level:"1"},{id:"sec_2_2",title:"2.1. Hardware design",level:"2"},{id:"sec_2_3",title:"2.1.1. On-board control computer sub-system",level:"3"},{id:"sec_3_3",title:"2.1.2. Power sub-system",level:"3"},{id:"sec_4_3",title:"2.1.3. Communication sub-system",level:"3"},{id:"sec_5_3",title:"Table 2.",level:"3"},{id:"sec_6_3",title:"2.1.5. Ground station sub-system",level:"3"},{id:"sec_7_3",title:"2.1.6. Execution sub-system",level:"3"},{id:"sec_9_2",title:"2.2. Software design",level:"2"},{id:"sec_11",title:"3. USV dynamic modeling",level:"1"},{id:"sec_11_2",title:"3.1. Active quasi-LPV modeling",level:"2"},{id:"sec_12_2",title:"3.2. Identification results",level:"2"},{id:"sec_14",title:"4. Application experiments",level:"1"},{id:"sec_14_2",title:"4.1. Rescuing experiment",level:"2"},{id:"sec_15_2",title:"4.2. Water sampling experiment",level:"2"},{id:"sec_17",title:"5. Conclusions",level:"1"}],chapterReferences:[{id:"B1",body:'Hirabayashi, Y., et al., Global flood risk under climate change. Nature Climate Change, 2013. 3(9): p. 816–821.'},{id:"B2",body:'Murphy, R.R., et al., Cooperative use of unmanned sea surface and micro aerial vehicles at Hurricane Wilma. Journal of Field Robotics, 2008. 25(3): p. 164–180.'},{id:"B3",body:'Murphy, R.R., et al., Marine heterogeneous multirobot systems at the great Eastern Japan Tsunami recovery. Journal of Field Robotics, 2012. 29(5): p. 819–831.'},{id:"B4",body:'Qi, J., et al. Design and implement of a trimaran unmanned surface vehicle system. In: International Conference on Information Acquisition, 2007. ICIA’07. 2007. IEEE.'},{id:"B5",body:'Li, M., et al. Design and implementation of a new jet-boat based unmanned surface vehicle. In: International Conference on Automatic Control and Artificial Intelligence (ACAI 2012), 2012. IET.'},{id:"B6",body:'Faltinsen, O.M., Hydrodynamics of high-speed marine vehicles. 2005, Cambridge, UK: Cambridge University Press.'},{id:"B7",body:'Shamma, J.S., An overview of LPV systems, in control of linear parameter varying systems with applications. 2012, Springer: Berlin. p. 3–26.'},{id:"B8",body:'Raïssi, T., G. Videau, and A. Zolghadri, Interval observer design for consistency checks of nonlinear continuous-time systems. Automatica, 2010. 46(3): p. 518–527.'},{id:"B9",body:'Hwang, W.-Y., Application of system identification to ship maneuvering, in Ocean Engineering. 1980, MIT: Cambridge, MA.'},{id:"B10",body:'Zhang, X.-G. and Z.-J. Zou, Identification of Abkowitz model for ship manoeuvring motion using ε-support vector regression. Journal of Hydrodynamics, Series B, 2011. 23(3): p. 353–360.'},{id:"B11",body:'Peng, Q., F. Peng, and L. Ye, Experimental study on GFRP pipes under axial compression. Frontiers of Architecture & Civil Engineering in China, 2008. 2(1): p. 73–78.'},{id:"B12",body:'Nomoto, K., On the steering qualities of ships. International Shipbuilding Progress, 1957. 4(35): p. 75–82.'},{id:"B13",body:'Yu, Z., X. Bao, and K. Nonami, Course keeping control of an autonomous boat using low cost sensors. Journal of System Design and Dynamics, 2008. 2(1): p. 389–400.'},{id:"B14",body:'Fossen, T.I., Guidance and control of ocean vehicles. Vol. 199. 1994, New York: Wiley.'},{id:"B15",body:'Sarker, M.M.H., et al., Modelling and analysis of control system for a multi-robotic system. International Journal of Intelligent Control and Systems, 2009. 14(4): p. 221–227.'},{id:"B16",body:'Fossen, T.I., Handbook of marine craft hydrodynamics and motion control. 2011, New York: John Wiley & Sons.'},{id:"B17",body:'Kahveci, N.E. and P.A. Ioannou, Adaptive steering control for uncertain ship dynamics and stability analysis. Automatica, 2013. 49(3): p. 685–697.'},{id:"B18",body:'Abkowitz, M.A., Lectures on ship hydrodynamics--Steering and manoeuvrability. 1964, Hydroand Aerodynamic’s Laboratory: Lyngby.'},{id:"B19",body:'Cummins, W., The impulse response function and ship motions. 1962, MIT: Cambridge, MA.'},{id:"B20",body:'Padilla, A., J.I. Yuz, and B. Herzer, Continuous-time system identification of the steering dynamics of a ship on a river. International Journal of Control, 2014. 87(7): p. 1387–1405.'},{id:"B21",body:'Xiong, J., et al., Active quasi-LPV modeling and identification for a Water-Jet Propulsion USV: an experimental study. IFAC-PapersOnLine, 2015. 48(28): p. 1359–1364.'}],footnotes:[],contributors:[{corresp:null,contributorFullName:"Junfeng Xiong",address:null,affiliation:'
State Key Laboratory of Robotics of Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang, China
University of Chinese Academy of Sciences, Beijing, China
State Key Laboratory of Robotics of Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang, China
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1. Introduction
Besides poor treatment and vaccination programs, a healthy immune system and antioxidant mechanism are the essential defenders considering the current viral diseases. The viral diseases hosted in a body has several impacts on organs and systems. Also, long-term drug use or vaccination programs can cause some acute side effects on the body, such as gut microbiota, immunity, lung tissue, etc. Therefore, probiotics, prebiotics, vitamins, natural antioxidants have been generally recommended over the years. Probiotics named live microorganisms have beneficial effects on systems, and they have been used successfully. Prebiotics are non-digestible foods that stimulate intestinal tissue growth and modulate immunity. Vitamins, minerals, and natural antioxidants have been used to enhance immune activity and health in viral diseases. It can be said that all these supplements are essential for adequate homeostasis.
Today, evaluate the most effective, economical, and safe vaccines is a significant challenge. Thus, some crucial organisms have been interested in vaccine production as well as nutrition. Among the different vaccination process, yeasts have a broad interest in the scientific area (Figure 1). These unicellular and saprotrophic fungi have been used as a biological model. They have also been accepted as critical models for experiments due to their cellular structure, components, and rapid growth. Yeast also can be cultured easily and manipulated genetically. These features showed that yeasts are beneficial to identify the cellular mechanism of virus and vaccine programs safely [1, 2].
Figure 1.
Biomedical applications of yeasts.
The yeast Saccharomyces, the essential eukaryotic organism, have been used as a biological model. Nevertheless, there is a notable gene homology in this yeast with human genes. In this chapter, we try to identify the Saccharomyces yeast as a useful model for biological experiments and observe the importance of viruses, viral diseases, and vaccines.
2. Saccharomyces
Saccharomyces cerevisiae is a model organism extensively used to investigate the biology of eukaryotic cells. It is widely used as a cell factory for producing pharmaceuticals, chemicals, and biofuels [3].
Saccharomyces, which is a genus belonging to the Saccharomyces fungus kingdom, includes many yeast species. The name of Saccharomyces is derived from the Latin words saccharo- (sugar) and - Greek mikes (mushrooms). These yeasts were initially suggested in 1680, and named Saccharomyces in 1837. A successful systemic concept on these higher eukaryotes was designed by Mayr [4]. Yeasts’ cultured forms have been used for thousands of years due to rapid reproduction and essential components. Typical features of Saccharomyces are the usage of nitrate and ability for the fermentation of carbohydrates. Saccharomyces have an excellent capacity for ethanol production, and they are suitable yeasts for large-scale fermentation [5]. These important yeasts can be used for the food industry to produce several foods such as bread, beer, wine, distilled spirits, and industrial alcohols. The most knows are S. cerevisiae, S. boullardii, S. pombe, S. pastorianus, and S. paradoxus, mostly used for food and treatments. Nevertheless, these yeasts have a small nucleus and central vacuole and have glucan and mannoproteins on their cell walls. Saccharomyces include a single linear double-stranded DNA, ribosomal proteins, and non-ribosomal molecules, like other eukaryotes. It was suggested that their genetic structure is beneficial for the model organism, especially S. cerevisiae [6].
S. cerevisiae a single celled organism that is used as a model organism. These yeasts have been studied to understand the concept of cell cycle regulation, DNA repair, and other cellular mechanisms. It was also reviewed that a model to identify the mutations in the cell cycle in cancer and some diseases, especially neurodegenerative diseases [7]. However, a form of S. cerevisiae called S. boulardii had been observed in clinical trials for treatment such as inflammation and diarrhea. Mc Farland and Bernasconi reported that S. boulardii is a wild type of Saccharomyces, a pharmaceutical agent [8]. The action of S. boulardii has been described by releasing trypsin-like protease, which inhibits the toxins in inflammations [9].
Schizosaccharomyces pombe is a fission yeast that was isolated in 1893 by Paul Lindner from East African millet beer. It is a model organism for eukaryotic cell biology and molecular biology as well as S. boulardii and S. cerevisiae. In 1590, Mitchison was firstly studied with this yeast in an experimental organism. Eser et al. reported that it could be used to treat diabetes and other diseases [10]. This fission yeast has been studied for eukaryotic RNA metabolism due to its gene expression.
S. bayanus (S. eubayanus), S. paradoxus, and S. pastorianus have similar genome size with S. cerevisiae. They all have been studied for DNA reassociation studies [11]. S. pastorianus is a lager yeast, an interspecific hybrid between S. cerevisiae and another S. bayanus (S. eubayanus) [12]. It is also a synonym of S. carlsbergensis and closely related to genus S. cerevisiae. Another wild type of yeast, S. paradoxus, can be isolated from nature, especially tree exudates or oils. It is an essential type of yeast for genetic and genomic studies. A yeast named S. bayanus (S. eubayanus), which was isolated from the tree, is related to S. cerevisiae and S. pastorianus [13]. S. bayanus has been used for genomic studies, expression patterns, and nucleosomes profiles [14, 15, 16].
Saccharomyces yeasts focus on the dietary field as a probiotic and the process of treating the disease. Belong the probiotic action; these yeasts have several vital roles on mechanisms such as bacterial adhesion, enhancement of immune cells and responses, modulation of the signaling pathways of the host, and improvement of the strengthening of enterocytes [17]. Nevertheless, Saccharomyces are used as model organisms in biological studies, particularly chemicals and pharmaceuticals.
3. Experimental organism for pharmaceutical industry
Over the last fifty years, remarkable progress in our ability to produce advanced drugs has improved people’s health and longevity. Pharmaceutical proteins are one of the fastest-growing groups of medicines and are currently critical to treating many diseases [18].
Proteins have a catalyzer role in several metabolic reactions as well as an essential responsibility for cellular mechanisms. There are unique systems that can be used to produce proteins for the pharmaceutical industry from a single cell to multiple organisms, including eukaryotes, especially yeasts. Dozens of pharmaceutical proteins, including insulin, vaccines, and blood factors, produced by S. cerevisiae, have been commercialized. It was reviewed that yeasts are essential for biological activities, mainly producing the purified product due to its cost-effective, fast production like bacteria and high density of cell cultures [19]. In recent years, indeed, as a model organism, yeasts have been provided to identify the pathogenesis and role for diseases, especially S. cerevisiae and S. pombe.
The yeast Saccharomyces has been accepted as the significant organism for several metabolisms such as cell cycle, biogenesis, protein folding, genetic manipulation, recombination, etc. [20]. S. cerevisiae is a unicellular microbial organism that grows fast, tolerances to chemicals, and cultured easily. It was reported that this yeast could discover the process of diseases because of the conservation of molecular interactions from yeast to humans [21, 22]. On the other hand, S. cerevisiae can be an essential organism for recombinant protein production for pharmacy. It has full cellular organelles and membrane compartments that produce many eukaryotic proteins, including humans’ [23]. Initially, the essential biopharmaceuticals insulin and its analogs have been produced by S. cerevisiae. Researchers have reported other important biopharmaceuticals such as the human serum albumin, hepatitis vaccines, and virus-like particles for vaccination (Table 1). Also, several medicines have been produced with S. cerevisiae until 2012 reported by the European Medicines Agency [18]. Furthermore, current studies showed that metabolic engineering pathways and optimization procedures of S. cerevisiae are essential for producing recombinant proteins for pharmaceuticals and biomedical areas [18, 19]. S. cerevisiae carries out human-like glycoprotein that is efficient for producing recombinant proteins. Protein secretion of S. cerevisiae is complex processing that follows as transcription, translation, translocation, post-translational modifications, folding, peptide cleavage, glycosylation, sorting, and secretion. This important organism enables genetic modifications. It was reported that the first eukaryotic organism sequenced DNA in S. cerevisiae [41]. Due to the protein misfolding and aggregation, S. cerevisiae has been used as a model organism.
Hadiji-Abbes et al. [30], Zhang et al. [31], King et al. [32], Kaslow and Shiloach [33], Fazlalipour et al. [34].
Virus like particles
Protein
Jacobs et al. [35], Kim et al. [36], Kim et al. [37].
Gene expression systems
Gene
Malak et al. [38], van Ooyen et al. [39], Vierira Gomes et al. [40].
Table 1.
Examples of bioparhamaceutical products of Saccharomyces.
Nevertheless, S. pombe has been accepted as a model organism together with S. cerevisiae. This fission yeast is used as a successful host. It was reviewed that S. pombe and generated strains have significant facilitation for producing drug glucuronides [42, 43]. The classical yeast genetics approaches can be described for S. pombe. It has been accepted as the most ancient yeast molecule. However, S. pombe has been more advanced evolutionarily than other yeasts. S. pombe has become a model organism until 2002 [44, 45].
Recombinant proteins are recognized as an important part of the drug industry. Among these proteins, Saccharomyces has greater attention than others due to their eukaryotic properties, easy genetic manipulation, and capable of modifications. S. cerevisiae emerges as the most common host to express heterologous genes and therapeutic proteins [46]. This organism may provide a simple background for isotype expressions, and thereby drug metabolism studies can be easily associated with genome screens, underlying toxicity, and encoded genomes.
4. Antiviral strategies
While the vaccines currently available have proven invaluable in the fight against infectious diseases and eradicating viruses, there are many drawbacks to the current vaccine preparation or application regimen despite these successes. Certain limitations of conventional vaccines require multiple adjuvants and injections to induce a necessary or optimal immune response. Another reason is the constant increase in the number of post-vaccination allergic reactions or hypersensitivities in a specific group of people [47, 48].
Today, there are several critical viral diseases such as human hepatitis B and C, immunodeficiency virus (HIV), severe acute respiratory syndrome coronavirus (SARS), coronavirus-disease 2019 (COVID19), etc. Due to the inadequacy of treatment options for these infections, new antiviral strategies and model organisms, particularly yeast, were of interest to the researchers.
Yeasts have a delivery system for nucleic acids, and thus they can be an alternative for virus description. Besides, a humanized yeast system was identified for yeast/virus systems to study diseases [49]. Yeasts are used for subunit vaccine formulations with producing antigens against viruses. It was reviewed that yeast can be used for vaccine development in such strategies; whole recombinant yeast, virus-like particles, yeast display, and purified protein immunogens [50]. Among yeasts, S. cerevisiae has been accepted as a versatile model organism for viruses’ research, from the wire of public health to vaccine production.
Rosenfeld and Racaniello [51] reported that hepatitis C virus (HCV) was demonstrated in S. cerevisiae, and all proteins for the virus were encoded. Another study reported that S. cerevisiae could safely express the hepatitis B surface antigen in prophylactic vaccines [52]. Researchers observed that yeast could help clarify the function of viruses’ proteins with dissection of RNA viruses’ life cycle [53, 54]. Nevertheless, several protein immunogens can be purified from Saccharomyces. These immunogen proteins derived from yeasts are associated with virus-like particles. Virus-like particles can provide an alternative for viruses, and FDA approved this vaccine for hepatitis B and papillomavirus [55]. Also, the circumsporozoite protein derived from S. cerevisae is an immunodominant antibody of malaria. This preparation increased the antibodies and thereby neutralized the sporozoites [56]. Due to the yeast membrane permeability, S. cerevisiae enables entry to the chemical compounds and provides virus-host interactions. Some researchers showed that beta-glucan of the yeast cell wall could provide the immune response that important for vaccine development [57].
All things considered, the yeast-based carrier system can be a potential model to develop the vaccine insights of virus-host interactions. The yeast strategies can improve the recognition of pathogen antigens peptides, activate the immune response, and also modulate the yeast-based vaccines. Researchers for further pioneering findings have still endured the studies.
5. Future perspectives
There have been many illnesses that have not been controlled by vaccination and new ones as well. Mutation, genetic exchange, environmental and interspecific transference, or human contact are the most emerging diseases. However, new scientific technologies, model organisms and a number of researchers have proven beneficial to vaccination strategies. In this respect, it is possible to observe yeasts for the upcoming vaccines for several diseases.
Yeast engineered to the virus has been accepted as an ideal therapeutic approach. This vaccine’s strategy is improving humoral immunity due to the ability of yeast to the generation of immune responses.
There is a numerous increasing study to obtain the vaccine strategy of yeasts. Studies in yeast proteins and cell wall components, including beta-glucan, may become more critical for vaccine strategies under different phases of clinical trials on animals or humans. According to the essential features of yeast, the yeast-based vaccine strategy is being necessary for vaccine development. It has foreseen that diversity of yeast strains will improve in the future.
6. Conclusion
The yeast system provides invaluable antiviral strategies. Significant studies have been conducted on yeast progression in the identification of viral diseases and antiviral strategies. Based on a better understanding of yeast protein and viruses, the search for new vaccines and medications for viral or pandemic diseases is safer and more effective. However, experiments with animal models and human cells are still underway in many types of yeast. Knowledge of these new biological systems and technologies, models, and organisms will open up new science avenues.
Conflict of interest
The authors declare no conflict of interest.
Acronyms and abbreviations
Appendices and nomenclature
Yeast
The most important eukaryote; Saccharomyces.
Single celled organism
Saccharomyces cerevisiae
Nucleosomes
DNA, RNA
Biopharmaceuticals
insulin and its analogs
Eukaryotes
The organisms whose cells have a nucleus enclosed within a nuclear envelope
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It has been alleviated that this yeast helps clarify the function of individual proteins in pathogenic viruses. To clarify virus life and host interactions, virus replication systems in Saccharomyces were interested in scientists. The new antiviral strategies with yeasts suggest the biological mechanism of a pathogen virus. Due to the variety of diseases and current epidemic conditions, these organisms play an essential role in prevention and treatment. This chapter will try to update Saccharomyces’ scientific discoveries with the most recent and up-to-date literature.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/75092",risUrl:"/chapter/ris/75092",signatures:"Nilay Seyidoglu and Cenk Aydin",book:{id:"10214",type:"book",title:"Saccharomyces",subtitle:null,fullTitle:"Saccharomyces",slug:"saccharomyces",publishedDate:"July 21st 2021",bookSignature:"Thalita Peixoto Basso and Luiz Carlos Basso",coverURL:"https://cdn.intechopen.com/books/images_new/10214.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:"978-1-83968-790-7",printIsbn:"978-1-83968-789-1",pdfIsbn:"978-1-83968-791-4",isAvailableForWebshopOrdering:!0,editors:[{id:"139174",title:"Ph.D.",name:"Thalita",middleName:null,surname:"Peixoto Basso",slug:"thalita-peixoto-basso",fullName:"Thalita Peixoto Basso"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"191307",title:"Dr.",name:"Nilay",middleName:null,surname:"Seyidoglu",fullName:"Nilay Seyidoglu",slug:"nilay-seyidoglu",email:"nseyidoglu@nku.edu.tr",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"Namık Kemal University",institutionURL:null,country:{name:"Turkey"}}},{id:"192225",title:"Prof.",name:"Cenk",middleName:null,surname:"Aydin",fullName:"Cenk Aydin",slug:"cenk-aydin",email:"caydin@uludag.edu.tr",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Saccharomyces",level:"1"},{id:"sec_3",title:"3. Experimental organism for pharmaceutical industry",level:"1"},{id:"sec_4",title:"4. Antiviral strategies",level:"1"},{id:"sec_5",title:"5. Future perspectives",level:"1"},{id:"sec_6",title:"6. Conclusion",level:"1"},{id:"sec_10",title:"Conflict of interest",level:"1"},{id:"sec_9",title:"Acronyms and abbreviations",level:"1"},{id:"sec_9",title:"Appendices and nomenclature",level:"1"}],chapterReferences:[{id:"B1",body:'Wickner RB, Fujimura T, Esteban R. Viruses and prions of Saccharomyces cerevisiae. Adv Virus Res. 2013;86:1-36. doi:10.1016/B978-0-12-394315-6.00001-5'},{id:"B2",body:'Walch B, Breinig T, Schmitt MJ, Breinig F. Delivery of functional DNA and messenger RNA to mammalian phagocytic cells by recombinant yeast. Gene Therapy.2012;19:237-245. DOI: 10.1038/gt.2011.121'},{id:"B3",body:'Nielsen J, Keasling JD. Engineering cellular metabolism. Cell. 2016;164(6):1185-1197. 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Pharmaceutical protein production by yeast: towards production of human blood proteins by microbial fermentation. Curr Opin Biotechnol. 2012;23(6):965-971. DOI: 10.1016/j.copbio.2012.03.011'},{id:"B28",body:'Egel-Mitani M, Andersen AS, Diers II, Hach M, Thim L, Hastrup S, Vad K. Yield improvement of heterologous peptides expressed in yps1-disrupted Saccharomyces cerevisiae strains. Enzyme Microb Technol. 2000;26(9-10):671-677. DOI: 10.1016/s0141-0229(00)00158-7'},{id:"B29",body:'Song GY, Chung BH. Overproduction of human parathyroid hormone by fed-batch culture of a Saccharomyces cerevisiae mutant lacking yeast aspartic protease 3. Process Biochem. 1999;35(5):503-508. DOI: 10.1016/S0032-9592(99)00097-7'},{id:"B30",body:'Hadiji-Abbes N, Martin M, Benzina W, Karray-Hakim H, Gergely C, Gargouri A, Mokhad-Gargouri R. Extraction and purification of hepatitis B virus-like M particles from a recombinant Saccharomyces cerevisiae strain using alumina powder. J Virol Methods. 2013;187:132-137. DOI: 10.1016/j.jviromet.2012.09.023'},{id:"B31",body:'Zhang L, Liu J, Lu J, Yan B, Song L, Li, L, Cui F, Zhang G, Wang F, Liang X, Xu A. Antibody response to revaccination among adult non-responders to primary Hepatitis B vaccination in China. Hum Vaccin Immunother. 2015a;11:2716-2722. DOI: 10.1080/21645515.2015.1045172'},{id:"B32",body:'King TH, Shanley CA, Guo Z, Bellgrau D, Rodell T, Furney S, Henao-Tamayo M, Orme IM. GI-19007, a novel Saccharomyces cerevisiae-based therapeutic vaccine against tuberculosis. Clin Vaccine Immunol. 2017;24:e00245–e00217. DOI: 10.1128/CVI.00245-17'},{id:"B33",body:'Kaslow DC, Shiloach J. Production, purification and immunogenicity of a malaria transmission-blocking vaccine candidate: TBV25H expressed in yeast and purified using nickel-NTA agarose. Biotechnology (N Y). 1994;12:494-499. DOI: 10.1038/nbt0594-494'},{id:"B34",body:'Fazlalipour M, Keyvani H, Monavari SH, Mollaie HR. Expression, purification and immunogenic description of a hepatitis C virus recombinant CoreE1E2 protein expressed by yeast Pichia pastoris. Jundishapur J Microbiol. 2015;8:e17157. DOI: 10.5812/jjm.8(4)2015.17157'},{id:"B35",body:'Jacobs E, Rutgers T, Voet P, Dewerchin M, Cabezon T, de Wilde M. Simultaneous synthesis and assembly of various hepatitis B surface proteins in Saccharomyces cerevisiae. Gene 1989;80:279-291. DOI: 10.1016/0378-1119(89)90292-8'},{id:"B36",body:'Kim HJ, Kim SY, Lim SJ, Kim JY, Lee SJ, Kim HJ. One-step chromatographic purification of human papillomavirus type 16 L1 protein from Saccharomyces cerevisiae. Protein Expression Purif. 2010;70:68-74. DOI: 10.1016/j.pep.2009.08.005'},{id:"B37",body:'Kim HJ, Lee JY, Kang HA,Lee Y, Park EJ, Kim HJ. Oral immunization with whole yeast producing viral capsid antigen provokes a stronger humoral immune response than purified viral capsid antigen. Lett Appl Microbiol. 2014;58:285-291. DOI: 10.1111/lam.12188'},{id:"B38",body:'Malak A, Baronian K, Kunze G. Blastobotrys (Arxula) adeninivorans: a promising alternative yeast for biotechnology and basic research. Yeast. 2016;33:535-547. DOI: 10.1002/yea.3180'},{id:"B39",body:'van Ooyen AJ, Dekker P, Huang M, Olsthoorn MMA, Jacobs DI, Colussi PA, Taron CH. Heterologous protein production in the yeast Kluyveromyces lactis. FEMS Yeast Res. 2006;6:381-392. DOI: 10.1111/j.1567-1364.2006.00049.x'},{id:"B40",body:'Vieira Gomes AM, Souza Carmo T, Silva Carvalho L, Mendonça Bahia F, Skorupa Parachin N. Comparison of yeasts as hosts for recombinant protein production. Microorganisms. 2018;6(2):38. OI: 10.3390/microorganisms6020038'},{id:"B41",body:'Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG. Life with 6000 genes. Science. 1996;274(5287):546, 563-547. DOI: 10.1126/science.274.5287.546'},{id:"B42",body:'Giga-Hama Y, Kumagai H. Expression system for forein genes using the fission yeast Schizosaccharomyces pombe. Biotechnology and Applied Biochemistry. 2000;30(3):235-244. DOI: 10.1111/j.1470-8744.1999.tb00776.x'},{id:"B43",body:'Drăgan CA, Buchheit D, Bischoff D, Ebner T, Bureik M. Glucuronide production by whole-cell biotransformation using genetically engineered fission yeast Schizosaccharomyces pombe. Drug Metab Dispos. 2010;38(3):509-515. doi: 10.1124/dmd.109.030965'},{id:"B44",body:'Wood V, Gwilliam R, Rajandream MA, Lyne M, Lyne R, Stewart A, Sgouros J, Peat N, Hayles J, Baker S, Basham D, Bowman S, Brooks K, Brown D, Brown S, Chillingworth T, Churcher C, Collins M, Connor R, Cronin A, Davis P, Feltwell T, Fraser A, Gentles S, Goble A, Hamlin N, Harris D, Hidalgo J, Hodgson G, Holroyd S, Hornsby T, Howarth S, Huckle EJ, Hunt S, Jagels K, James K, Jones L, Jones M, Leather S, McDonald S, McLean J, Mooney P, Moule S, Mungall K, Murphy L, Niblett D, Odell C, Oliver K, O\'Neil S, Pearson D, Quail MA, Rabbinowitsch E, Rutherford K, Rutter S, Saunders D, Seeger K, Sharp S, Skelton J, Simmonds M, Squares R, Squares S, Stevens K, Taylor K, Taylor RG, Tivey A, Walsh S, Warren T, Whitehead S, Woodward J, Volckaert G, Aert R, Robben J, Grymonprez B, Weltjens I, Vanstreels E, Rieger M, Schäfer M, Müller-Auer S, Gabel C, Fuchs M, Düsterhöft A, Fritzc C, Holzer E, Moestl D, Hilbert H, Borzym K, Langer I, Beck A, Lehrach H, Reinhardt R, Pohl TM, Eger P, Zimmermann W, Wedler H, Wambutt R, Purnelle B, Goffeau A, Cadieu E, Dréano S, Gloux S, Lelaure V, Mottier S, Galibert F, Aves SJ, Xiang Z, Hunt C, Moore K, Hurst SM, Lucas M, Rochet M, Gaillardin C, Tallada VA, Garzon A, Thode G, Daga RR, Cruzado L, Jimenez J, Sánchez M, del Rey F, Benito J, Domínguez A, Revuelta JL, Moreno S, Armstrong J, Forsburg SL, Cerutti L, Lowe T, McCombie WR, Paulsen I, Potashkin J, Shpakovski GV, Ussery D, Barrell BG, Nurse P. The genome sequence of Schizosaccharomyces pombe. Nature. 2002;415:871-880. DOI: 10.1038/nature724'},{id:"B45",body:'Hoffman CS, Wood V, Fantes PA. An ancient yeast for young geneticists: A primer on the Schizosaccharomyces pombe model system. Genetics. 2015;201:403-423. DOI: 10.1534/genetics.115.181503'},{id:"B46",body:'Darby RA, Cartwright SP, Dilworth MV, Bill RM. Which yeast species shall I choose? Saccharomyces cerevisiae versus Pichia pastoris (review). Methods Mol Biol. 2012;866:11-23. DOI: 10.1007/978-1-61779-770-5_2'},{id:"B47",body:'Shams H. Recent developments in veterinary vaccinology. Vet J. 2005;170(3):289-299. DOI: 10.1016/j.tvjl.2004.07.004'},{id:"B48",body:'Fang Y, Liu MQ, Chen L, Zhu ZG, Zhu RZ, Hu Q. Rabies post-exposure prophylaxis for a child with severe allergic reaction to rabies vaccine. Hum Vaccin Immunother 2016;12:1802-1804. DOI: 10.1080/21645515.2016.1143158'},{id:"B49",body:'Mager WH, Winderickx J. Yeast as a model for medical and medicinal research. Trends Pharmacol Sci. 2005;26:265-273. DOI: 10.1016/j.tips.2005.03.004'},{id:"B50",body:'Kumar R, Kumar P. Yeast-based vaccines: New perspective in vaccine development and application. FEMS Yeast Research. 2019;19. DOI: 10.1093/femsyr/foz007'},{id:"B51",body:'Rosenfeld AB, Racaniello VR. Hepatitis C virus internal ribosome entry site-dependent translation in Saccharomyces cerevisiae is independent of polypyrimidine tract-binding protein, poly(rC)-binding protein 2, and La protein 1. J Virol. 2005;79:10126-10137. DOI: 10.1128/JVI.79.16.10126-10137.2005'},{id:"B52",body:'Valenzuela P, Medina A, Rutter WJ, Ammerer G, Hall BD. Synthesis and assembly of hepatitis B virus surface antigen particles in yeast. Nature. 1982;298:347-350. DOI: 10.1038/298347a0'},{id:"B53",body:'Blanco R, Carrasco L, Ventoso I. Cell killing by HIV-1 protease. J Biol Chem. 2003;278:1086-1093. DOI: 10.1074/jbc.M205636200'},{id:"B54",body:'Kapoor P, Lavoie BD, Frappier L. EBP2 plays a key role in Epstein-Barr virus mitotic segregation and is regulated by aurora family kinases. Mol Cell Biol. 2005;25:4934-4945. DOI: 10.1128/MCB.25.12.4934-4945.2005'},{id:"B55",body:'Zhang X, Xin L, Li S, Fang M, Zhang J, Xia N, Zhao Q. Lessons learned from successful human vaccines: delineating key epitopes by dissecting the capsid proteins. Hum Vaccine Immunotherapeutics 2015;11:1277-1292. DOI: 10.1080/21645515.2015.1016675'},{id:"B56",body:'Nussenzweig V, Barr P, inventors; New York University, Chiron Corporation, assignee. Vaccine against the sporozoite stage of malaria. Patent US4997647A. 1991'},{id:"B57",body:'Karumuthil-Melethil S, Gudi R, Johnson BM, Perez N, Vasu C. Fungal βglucan, a Dectin-1 ligand, promotes protection from type 1 diabetes by inducing regulatory innate immune response. J Immunol 2014;193:3308-3321. DOI: 10.4049/jimmunol.1400186'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Nilay Seyidoglu",address:"nseyidoglu@nku.edu.tr",affiliation:'
Department of Physiology, Faculty of Veterinary Medicine, Tekirdag Namik Kemal University, Turkey
Department of Physiology, Faculty of Veterinary Medicine, Bursa Uludag University, Turkey
'}],corrections:null},book:{id:"10214",type:"book",title:"Saccharomyces",subtitle:null,fullTitle:"Saccharomyces",slug:"saccharomyces",publishedDate:"July 21st 2021",bookSignature:"Thalita Peixoto Basso and Luiz Carlos Basso",coverURL:"https://cdn.intechopen.com/books/images_new/10214.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:"978-1-83968-790-7",printIsbn:"978-1-83968-789-1",pdfIsbn:"978-1-83968-791-4",isAvailableForWebshopOrdering:!0,editors:[{id:"139174",title:"Ph.D.",name:"Thalita",middleName:null,surname:"Peixoto Basso",slug:"thalita-peixoto-basso",fullName:"Thalita Peixoto Basso"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}}},profile:{item:{id:"330289",title:"Dr.",name:"Nouar",middleName:null,surname:"Charef",email:"charefnouar@gmail.com",fullName:"Nouar Charef",slug:"nouar-charef",position:null,biography:null,institutionString:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",totalCites:0,totalChapterViews:"0",outsideEditionCount:0,totalAuthoredChapters:"1",totalEditedBooks:"0",personalWebsiteURL:null,twitterURL:null,linkedinURL:null,institution:{name:"Mohamed-Cherif Messaadia University",institutionURL:null,country:{name:"Algeria"}}},booksEdited:[],chaptersAuthored:[{id:"74613",title:"Swelling Clay Parameters Investigation Using Design of Experiments (A Case Study)",slug:"swelling-clay-parameters-investigation-using-design-of-experiments-a-case-study-",abstract:"The present paper aims to investigate geotechnical parametric effects on the expansion behavior of clayey soils in Tebessa province northeast of Algeria using the Design Of Experiments (DOE) methodology. It has been used as powerful tools based on physical and mechanical properties, data results obtained within laboratory soil mechanics testing. This statistical tool methodology presents the factor screening design to determine the effect of different parameters such as dry unit weight, saturation degree, water content, plasticity index, etc., on the swelling pressure parameter which can be used as expansion behavior of clay indicator. All data previously collected in the studied prone area allows the ability of detailed analysis using design of experiment and parametric optimization process with response surface methodology (RSM). Each variable that present effects on swelling pressure is also discussed. Besides, the obtained models and equations related the factors affecting the expansion process have been determined. At the output process; the response desirability of the screening design methodology can be optimized by maximization or minimization of the optimal values affecting the swelling behavior. This process allows us to find the best describing models, whereas output results may be compared to empirical laboratory tests results to assess the RSM models.",signatures:"Yacine Berrah, Serhane Brahmi, Nouar Charef and Abderrahman Boumezbeur",authors:[{id:"324029",title:"Associate Prof.",name:"Yacine",surname:"Berrah",fullName:"Yacine Berrah",slug:"yacine-berrah",email:"yacineberrah29@gmail.com"},{id:"330289",title:"Dr.",name:"Nouar",surname:"Charef",fullName:"Nouar Charef",slug:"nouar-charef",email:"charefnouar@gmail.com"},{id:"330290",title:"Dr.",name:"Serhane",surname:"Brahmi",fullName:"Serhane Brahmi",slug:"serhane-brahmi",email:"brahmiserhane@gmail.com"},{id:"330292",title:"Prof.",name:"Abderrahmane",surname:"Boumezbeur",fullName:"Abderrahmane Boumezbeur",slug:"abderrahmane-boumezbeur",email:"boumezbeura@yahoo.fr"}],book:{id:"8157",title:"Engineering Geology",slug:"engineering-geology",productType:{id:"1",title:"Edited Volume"}}}],collaborators:[{id:"126962",title:"Dr.",name:"Leonid",surname:"Bogomolov",slug:"leonid-bogomolov",fullName:"Leonid Bogomolov",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"322937",title:"Dr.",name:"Lidia",surname:"Sim",slug:"lidia-sim",fullName:"Lidia Sim",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Schmidt Institute of Physics of the Earth",institutionURL:null,country:{name:"Russia"}}},{id:"322939",title:"Dr.",name:"Pavel",surname:"Kamenev",slug:"pavel-kamenev",fullName:"Pavel Kamenev",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Institute of Marine Geology and Geophysics",institutionURL:null,country:{name:"Vietnam"}}},{id:"324737",title:"Dr.",name:"Sylvestre Martial",surname:"Ntomba",slug:"sylvestre-martial-ntomba",fullName:"Sylvestre Martial Ntomba",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"324859",title:"Prof.",name:"Bisso",surname:"Dieudonné",slug:"bisso-dieudonne",fullName:"Bisso Dieudonné",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"324860",title:"Mrs.",name:"Magnekou Takamte",surname:"Rufine Christelle",slug:"magnekou-takamte-rufine-christelle",fullName:"Magnekou Takamte Rufine Christelle",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"326733",title:"Ph.D. Student",name:"Attah",surname:"Fakeye",slug:"attah-fakeye",fullName:"Attah Fakeye",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"326796",title:"Dr.",name:"Olusegun",surname:"Ige",slug:"olusegun-ige",fullName:"Olusegun Ige",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Ilorin",institutionURL:null,country:{name:"Nigeria"}}},{id:"326797",title:"Prof.",name:"Olufemi",surname:"Ogunsanwo",slug:"olufemi-ogunsanwo",fullName:"Olufemi Ogunsanwo",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Ilorin",institutionURL:null,country:{name:"Nigeria"}}},{id:"329051",title:"Prof.",name:"Joseph",surname:"Mvondo Ondoa",slug:"joseph-mvondo-ondoa",fullName:"Joseph Mvondo Ondoa",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null}]},generic:{page:{slug:"prior-publication-policy",title:"Prior Publication Policy",intro:"
The Internet has irrevocably changed the dynamics of scholarly communication and publishing. Consequently, we find it necessary to indicate, unambiguously, our definition of what we consider to be a published scientific work.
A significant number of working papers, early drafts, and similar work in progress are openly shared online between members of the scientific community. It has become common to announce one’s own research on a personal website or a blog to gather comments and suggestions from other researchers. Such works and online postings are, indeed, published in the sense that they are made publicly available. However, this does not mean that if submitted for publication by IntechOpen they are not original works. We differentiate between reviewed and non-reviewed works when determining whether a work is original and has been published in a scholarly sense or not.
\\n\\n
The significance of Peer Review cannot be overstated when it comes to defining, in our terms, what constitutes a published scientific work. Peer Review is widely considered to be the cornerstone of modern publishing processes and the key value-adding contribution to a scholarly manuscript that a publisher can make.
\\n\\n
Other than the issue of originality, research misconduct is another major issue that all publishers have to address. IntechOpen’s Retraction & Correction Policy and various publication ethics guidelines identify both redundant publication and (self)plagiarism to fall within the definition of research misconduct, thus constituting grounds for rejection or the issue of a Retraction if the work has already been published.
\\n\\n
In order to facilitate the tracking of a manuscript’s publishing history and its development from its earliest draft to the manuscript submitted, we encourage Authors to disclose any instances of a manuscript’s prior publication, whether it be through a conference presentation, a newspaper article, a working paper publicly available in a repository or a blog post.
\\n\\n
A note to the Academic Editor containing detailed information about a submitted manuscript’s previous public availability is the preferred means of reporting prior publication. This helps us determine if there are any earlier versions of a manuscript that should be disclosed to our readers or if any of those earlier versions should be cited and listed in a manuscript’s references.
\\n\\n
Some basic information about the editorial treatment of different varieties of prior publication is laid out below:
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1. CONFERENCE PAPERS & PRESENTATIONS
\\n\\n
Given that conference papers and presentations generally pass through some sort of peer or editorial review, we consider them to be published in the accepted scholarly sense, particularly if they are published as a part of conference proceedings.
\\n\\n
All submitted manuscripts originating from a previously published conference paper must contain at least 50% of new original content to be accepted for review and considered for publication.
\\n\\n
Authors are required to report any links their manuscript might have with their earlier conference papers and presentations in a note to the Academic Editor, as well as in the manuscript itself. Additionally, Authors should obtain any necessary permissions from the publisher of their conference paper if copyright transfer occurred during the publishing process. Failure to do so may prevent Us from publishing an otherwise worthy work.
\\n\\n
2. NEWSPAPER & MAGAZINE ARTICLES
\\n\\n
Newspaper and magazine articles usually do not pass through any extensive peer or editorial review and we do not consider them to be published in the scholarly sense. Articles appearing in newspapers and magazines rarely possess the depth and structure characteristic of scholarly articles.
\\n\\n
Submitted manuscripts stemming from a previous newspaper or magazine article will be accepted for review and considered for publication. However, Authors are strongly advised to report any such publication in an accompanying note to the External Editor.
\\n\\n
As with the conference papers and presentations, Authors should obtain any necessary permissions from the newspaper or magazine that published the work, and indicate that they have done so in a note to the External Editor.
\\n\\n
3. GREY LITERATURE
\\n\\n
White papers, working papers, technical reports and all other forms of papers which fall within the scope of the ‘Luxembourg definition’ of grey literature do not pass through any extensive peer or editorial review and we do not consider them to be published in the scholarly sense.
\\n\\n
Although such papers are regularly made publicly available via personal websites and institutional repositories, their general purpose is to gather comments and feedback from Authors’ colleagues in order to further improve a manuscript intended for future publication.
\\n\\n
When submitting their work, Authors are required to disclose the existence of any publicly available earlier drafts in a note to the Academic Editor. In cases where earlier drafts of the submitted version of the manuscript are publicly available, any overlap between the versions will generally not be considered an instance of self-plagiarism.
\\n\\n
4. SOCIAL MEDIA, BLOG & MESSAGE BOARD POSTINGS
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We feel that social media, blogs and message boards are generally used with the same intention as grey literature, to formulate ideas for a manuscript and gather early feedback from like-minded researchers in order to improve a particular piece of work before submitting it for publication. Therefore, we do not consider such internet postings to be publication in the scholarly sense.
\\n\\n
Nevertheless, Authors are encouraged to disclose the existence of any internet postings in which they outline and describe their research or posted passages of their manuscripts in a note to the Academic Editor. Please note that we will not strictly enforce this request in the same way that we would instructions we consider to be part of our conditions of acceptance for publication. We understand that it may be difficult to keep track of all one’s internet postings in which the researcher´s current work might be mentioned.
\\n\\n
In cases where there is any overlap between the Author´s submitted manuscript and related internet postings, we will generally not consider it to be an instance of self-plagiarism. This also holds true for any co-Author as well.
A significant number of working papers, early drafts, and similar work in progress are openly shared online between members of the scientific community. It has become common to announce one’s own research on a personal website or a blog to gather comments and suggestions from other researchers. Such works and online postings are, indeed, published in the sense that they are made publicly available. However, this does not mean that if submitted for publication by IntechOpen they are not original works. We differentiate between reviewed and non-reviewed works when determining whether a work is original and has been published in a scholarly sense or not.
\n\n
The significance of Peer Review cannot be overstated when it comes to defining, in our terms, what constitutes a published scientific work. Peer Review is widely considered to be the cornerstone of modern publishing processes and the key value-adding contribution to a scholarly manuscript that a publisher can make.
\n\n
Other than the issue of originality, research misconduct is another major issue that all publishers have to address. IntechOpen’s Retraction & Correction Policy and various publication ethics guidelines identify both redundant publication and (self)plagiarism to fall within the definition of research misconduct, thus constituting grounds for rejection or the issue of a Retraction if the work has already been published.
\n\n
In order to facilitate the tracking of a manuscript’s publishing history and its development from its earliest draft to the manuscript submitted, we encourage Authors to disclose any instances of a manuscript’s prior publication, whether it be through a conference presentation, a newspaper article, a working paper publicly available in a repository or a blog post.
\n\n
A note to the Academic Editor containing detailed information about a submitted manuscript’s previous public availability is the preferred means of reporting prior publication. This helps us determine if there are any earlier versions of a manuscript that should be disclosed to our readers or if any of those earlier versions should be cited and listed in a manuscript’s references.
\n\n
Some basic information about the editorial treatment of different varieties of prior publication is laid out below:
\n\n
1. CONFERENCE PAPERS & PRESENTATIONS
\n\n
Given that conference papers and presentations generally pass through some sort of peer or editorial review, we consider them to be published in the accepted scholarly sense, particularly if they are published as a part of conference proceedings.
\n\n
All submitted manuscripts originating from a previously published conference paper must contain at least 50% of new original content to be accepted for review and considered for publication.
\n\n
Authors are required to report any links their manuscript might have with their earlier conference papers and presentations in a note to the Academic Editor, as well as in the manuscript itself. Additionally, Authors should obtain any necessary permissions from the publisher of their conference paper if copyright transfer occurred during the publishing process. Failure to do so may prevent Us from publishing an otherwise worthy work.
\n\n
2. NEWSPAPER & MAGAZINE ARTICLES
\n\n
Newspaper and magazine articles usually do not pass through any extensive peer or editorial review and we do not consider them to be published in the scholarly sense. Articles appearing in newspapers and magazines rarely possess the depth and structure characteristic of scholarly articles.
\n\n
Submitted manuscripts stemming from a previous newspaper or magazine article will be accepted for review and considered for publication. However, Authors are strongly advised to report any such publication in an accompanying note to the External Editor.
\n\n
As with the conference papers and presentations, Authors should obtain any necessary permissions from the newspaper or magazine that published the work, and indicate that they have done so in a note to the External Editor.
\n\n
3. GREY LITERATURE
\n\n
White papers, working papers, technical reports and all other forms of papers which fall within the scope of the ‘Luxembourg definition’ of grey literature do not pass through any extensive peer or editorial review and we do not consider them to be published in the scholarly sense.
\n\n
Although such papers are regularly made publicly available via personal websites and institutional repositories, their general purpose is to gather comments and feedback from Authors’ colleagues in order to further improve a manuscript intended for future publication.
\n\n
When submitting their work, Authors are required to disclose the existence of any publicly available earlier drafts in a note to the Academic Editor. In cases where earlier drafts of the submitted version of the manuscript are publicly available, any overlap between the versions will generally not be considered an instance of self-plagiarism.
\n\n
4. SOCIAL MEDIA, BLOG & MESSAGE BOARD POSTINGS
\n\n
We feel that social media, blogs and message boards are generally used with the same intention as grey literature, to formulate ideas for a manuscript and gather early feedback from like-minded researchers in order to improve a particular piece of work before submitting it for publication. Therefore, we do not consider such internet postings to be publication in the scholarly sense.
\n\n
Nevertheless, Authors are encouraged to disclose the existence of any internet postings in which they outline and describe their research or posted passages of their manuscripts in a note to the Academic Editor. Please note that we will not strictly enforce this request in the same way that we would instructions we consider to be part of our conditions of acceptance for publication. We understand that it may be difficult to keep track of all one’s internet postings in which the researcher´s current work might be mentioned.
\n\n
In cases where there is any overlap between the Author´s submitted manuscript and related internet postings, we will generally not consider it to be an instance of self-plagiarism. This also holds true for any co-Author as well.
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Dr. Gaiceanu is a member of the National Council for Attesting Titles, Diplomas and Certificates, an expert of the Executive Agency for Higher Education, Research Funding, and a member of the Senate of the Dunarea de Jos University of Galati. He has been the head of the Integrated Energy Conversion Systems and Advanced Control of Complex Processes Research Center, Romania, since 2016. He has conducted several projects in power converter systems for electrical drives, power quality, PEM and SOFC fuel cell power converters for utilities, electric vehicles, and marine applications with the Department of Regulation and Control, SIEI S.pA. (2002–2004) and the Polytechnic University of Turin, Italy (2002–2004, 2006–2007). He is a member of the Institute of Electrical and Electronics Engineers (IEEE) and cofounder-member of the IEEE Power Electronics Romanian Chapter. He is a guest editor at Energies and an academic book editor for IntechOpen. He is also a member of the editorial boards of the Journal of Electrical Engineering, Electronics, Control and Computer Science and Sustainability. Dr. Gaiceanu has been General Chairman of the IEEE International Symposium on Electrical and Electronics Engineering in the last six editions.",institutionString:'"Dunarea de Jos" University of Galati',institution:{name:'"Dunarea de Jos" University of Galati',country:{name:"Romania"}}},{id:"4519",title:"Prof.",name:"Jaydip",middleName:null,surname:"Sen",slug:"jaydip-sen",fullName:"Jaydip Sen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/4519/images/system/4519.jpeg",biography:"Jaydip Sen is associated with Praxis Business School, Kolkata, India, as a professor in the Department of Data Science. His research areas include security and privacy issues in computing and communication, intrusion detection systems, machine learning, deep learning, and artificial intelligence in the financial domain. He has more than 200 publications in reputed international journals, refereed conference proceedings, and 20 book chapters in books published by internationally renowned publishing houses, such as Springer, CRC press, IGI Global, etc. Currently, he is serving on the editorial board of the prestigious journal Frontiers in Communications and Networks and in the technical program committees of a number of high-ranked international conferences organized by the IEEE, USA, and the ACM, USA. He has been listed among the top 2% of scientists in the world for the last three consecutive years, 2019 to 2021 as per studies conducted by the Stanford University, USA.",institutionString:"Praxis Business School",institution:null},{id:"320071",title:"Dr.",name:"Sidra",middleName:null,surname:"Mehtab",slug:"sidra-mehtab",fullName:"Sidra Mehtab",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00002v6KHoQAM/Profile_Picture_1584512086360",biography:"Sidra Mehtab has completed her BS with honors in Physics from Calcutta University, India in 2018. She has done MS in Data Science and Analytics from Maulana Abul Kalam Azad University of Technology (MAKAUT), Kolkata, India in 2020. Her research areas include Econometrics, Time Series Analysis, Machine Learning, Deep Learning, Artificial Intelligence, and Computer and Network Security with a particular focus on Cyber Security Analytics. Ms. Mehtab has published seven papers in international conferences and one of her papers has been accepted for publication in a reputable international journal. She has won the best paper awards in two prestigious international conferences – BAICONF 2019, and ICADCML 2021, organized in the Indian Institute of Management, Bangalore, India in December 2019, and SOA University, Bhubaneswar, India in January 2021. Besides, Ms. Mehtab has also published two book chapters in two books. Seven of her book chapters will be published in a volume shortly in 2021 by Cambridge Scholars’ Press, UK. Currently, she is working as the joint editor of two edited volumes on Time Series Analysis and Forecasting to be published in the first half of 2021 by an international house. Currently, she is working as a Data Scientist with an MNC in Delhi, India.",institutionString:"NSHM College of Management and Technology",institution:null},{id:"226240",title:"Dr.",name:"Andri Irfan",middleName:null,surname:"Rifai",slug:"andri-irfan-rifai",fullName:"Andri Irfan Rifai",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/226240/images/7412_n.jpg",biography:"Andri IRFAN is a Senior Lecturer of Civil Engineering and Planning. He completed the PhD at the Universitas Indonesia & Universidade do Minho with Sandwich Program Scholarship from the Directorate General of Higher Education and LPDP scholarship. He has been teaching for more than 19 years and much active to applied his knowledge in the project construction in Indonesia. His research interest ranges from pavement management system to advanced data mining techniques for transportation engineering. He has published more than 50 papers in journals and 2 books.",institutionString:null,institution:{name:"Universitas Internasional Batam",country:{name:"Indonesia"}}},{id:"314576",title:"Dr.",name:"Ibai",middleName:null,surname:"Laña",slug:"ibai-lana",fullName:"Ibai Laña",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/314576/images/system/314576.jpg",biography:"Dr. Ibai Laña works at TECNALIA as a data analyst. He received his Ph.D. in Artificial Intelligence from the University of the Basque Country (UPV/EHU), Spain, in 2018. He is currently a senior researcher at TECNALIA. His research interests fall within the intersection of intelligent transportation systems, machine learning, traffic data analysis, and data science. He has dealt with urban traffic forecasting problems, applying machine learning models and evolutionary algorithms. He has experience in origin-destination matrix estimation or point of interest and trajectory detection. Working with large volumes of data has given him a good command of big data processing tools and NoSQL databases. He has also been a visiting scholar at the Knowledge Engineering and Discovery Research Institute, Auckland University of Technology.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"314575",title:"Dr.",name:"Jesus",middleName:null,surname:"L. Lobo",slug:"jesus-l.-lobo",fullName:"Jesus L. Lobo",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/314575/images/system/314575.png",biography:"Dr. Jesús López is currently based in Bilbao (Spain) working at TECNALIA as Artificial Intelligence Research Scientist. In most cases, a project idea or a new research line needs to be investigated to see if it is good enough to take into production or to focus on it. That is exactly what he does, diving into Machine Learning algorithms and technologies to help TECNALIA to decide whether something is great in theory or will actually impact on the product or processes of its projects. So, he is expert at framing experiments, developing hypotheses, and proving whether they’re true or not, in order to investigate fundamental problems with a longer time horizon. He is also able to design and develop PoCs and system prototypes in simulation. He has participated in several national and internacional R&D projects.\n\nAs another relevant part of his everyday research work, he usually publishes his findings in reputed scientific refereed journals and international conferences, occasionally acting as reviewer and Programme Commitee member. Concretely, since 2018 he has published 9 JCR (8 Q1) journal papers, 9 conference papers (e.g. ECML PKDD 2021), and he has co-edited a book. He is also active in popular science writing data science stories for reputed blogs (KDNuggets, TowardsDataScience, Naukas). Besides, he has recently embarked on mentoring programmes as mentor, and has also worked as data science trainer.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"103779",title:"Prof.",name:"Yalcin",middleName:null,surname:"Isler",slug:"yalcin-isler",fullName:"Yalcin Isler",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRyQ8QAK/Profile_Picture_1628834958734",biography:"Yalcin Isler (1971 - Burdur / Turkey) received the B.Sc. degree in the Department of Electrical and Electronics Engineering from Anadolu University, Eskisehir, Turkey, in 1993, the M.Sc. degree from the Department of Electronics and Communication Engineering, Suleyman Demirel University, Isparta, Turkey, in 1996, the Ph.D. degree from the Department of Electrical and Electronics Engineering, Dokuz Eylul University, Izmir, Turkey, in 2009, and the Competence of Associate Professorship from the Turkish Interuniversity Council in 2019.\n\nHe was Lecturer at Burdur Vocational School in Suleyman Demirel University (1993-2000, Burdur / Turkey), Software Engineer (2000-2002, Izmir / Turkey), Research Assistant in Bulent Ecevit University (2002-2003, Zonguldak / Turkey), Research Assistant in Dokuz Eylul University (2003-2010, Izmir / Turkey), Assistant Professor at the Department of Electrical and Electronics Engineering in Bulent Ecevit University (2010-2012, Zonguldak / Turkey), Assistant Professor at the Department of Biomedical Engineering in Izmir Katip Celebi University (2012-2019, Izmir / Turkey). He is an Associate Professor at the Department of Biomedical Engineering at Izmir Katip Celebi University, Izmir / Turkey, since 2019. In addition to academics, he has also founded Islerya Medical and Information Technologies Company, Izmir / Turkey, since 2017.\n\nHis main research interests cover biomedical signal processing, pattern recognition, medical device design, programming, and embedded systems. He has many scientific papers and participated in several projects in these study fields. He was an IEEE Student Member (2009-2011) and IEEE Member (2011-2014) and has been IEEE Senior Member since 2014.",institutionString:null,institution:{name:"Izmir Kâtip Çelebi University",country:{name:"Turkey"}}},{id:"339677",title:"Dr.",name:"Mrinmoy",middleName:null,surname:"Roy",slug:"mrinmoy-roy",fullName:"Mrinmoy Roy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/339677/images/16768_n.jpg",biography:"An accomplished Sales & Marketing professional with 12 years of cross-functional experience in well-known organisations such as CIPLA, LUPIN, GLENMARK, ASTRAZENECA across different segment of Sales & Marketing, International Business, Institutional Business, Product Management, Strategic Marketing of HIV, Oncology, Derma, Respiratory, Anti-Diabetic, Nutraceutical & Stomatological Product Portfolio and Generic as well as Chronic Critical Care Portfolio. A First Class MBA in International Business & Strategic Marketing, B.Pharm, D.Pharm, Google Certified Digital Marketing Professional. Qualified PhD Candidate in Operations and Management with special focus on Artificial Intelligence and Machine Learning adoption, analysis and use in Healthcare, Hospital & Pharma Domain. Seasoned with diverse therapy area of Pharmaceutical Sales & Marketing ranging from generating revenue through generating prescriptions, launching new products, and making them big brands with continuous strategy execution at the Physician and Patients level. Moved from Sales to Marketing and Business Development for 3.5 years in South East Asian Market operating from Manila, Philippines. Came back to India and handled and developed Brands such as Gluconorm, Lupisulin, Supracal, Absolut Woman, Hemozink, Fabiflu (For COVID 19), and many more. In my previous assignment I used to develop and execute strategies on Sales & Marketing, Commercialization & Business Development for Institution and Corporate Hospital Business portfolio of Oncology Therapy Area for AstraZeneca Pharma India Ltd. Being a Research Scholar and Student of ‘Operations Research & Management: Artificial Intelligence’ I published several pioneer research papers and book chapters on the same in Internationally reputed journals and Books indexed in Scopus, Springer and Ei Compendex, Google Scholar etc. Currently, I am launching PGDM Pharmaceutical Management Program in IIHMR Bangalore and spearheading the course curriculum and structure of the same. I am interested in Collaboration for Healthcare Innovation, Pharma AI Innovation, Future trend in Marketing and Management with incubation on Healthcare, Healthcare IT startups, AI-ML Modelling and Healthcare Algorithm based training module development. I am also an affiliated member of the Institute of Management Consultant of India, looking forward to Healthcare, Healthcare IT and Innovation, Pharma and Hospital Management Consulting works.",institutionString:null,institution:{name:"Lovely Professional University",country:{name:"India"}}},{id:"1063",title:"Prof.",name:"Constantin",middleName:null,surname:"Volosencu",slug:"constantin-volosencu",fullName:"Constantin Volosencu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/1063/images/system/1063.png",biography:"Prof. Dr. Constantin Voloşencu graduated as an engineer from\nPolitehnica University of Timișoara, Romania, where he also\nobtained a doctorate degree. He is currently a full professor in\nthe Department of Automation and Applied Informatics at the\nsame university. Dr. Voloşencu is the author of ten books, seven\nbook chapters, and more than 160 papers published in journals\nand conference proceedings. He has also edited twelve books and\nhas twenty-seven patents to his name. He is a manager of research grants, editor in\nchief and member of international journal editorial boards, a former plenary speaker, a member of scientific committees, and chair at international conferences. His\nresearch is in the fields of control systems, control of electric drives, fuzzy control\nsystems, neural network applications, fault detection and diagnosis, sensor network\napplications, monitoring of distributed parameter systems, and power ultrasound\napplications. He has developed automation equipment for machine tools, spooling\nmachines, high-power ultrasound processes, and more.",institutionString:"Polytechnic University of Timişoara",institution:{name:"Polytechnic University of Timişoara",country:{name:"Romania"}}},{id:"221364",title:"Dr.",name:"Eneko",middleName:null,surname:"Osaba",slug:"eneko-osaba",fullName:"Eneko Osaba",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/221364/images/system/221364.jpg",biography:"Dr. Eneko Osaba works at TECNALIA as a senior researcher. He obtained his Ph.D. in Artificial Intelligence in 2015. He has participated in more than twenty-five local and European research projects, and in the publication of more than 130 papers. He has performed several stays at universities in the United Kingdom, Italy, and Malta. Dr. Osaba has served as a program committee member in more than forty international conferences and participated in organizing activities in more than ten international conferences. He is a member of the editorial board of the International Journal of Artificial Intelligence, Data in Brief, and Journal of Advanced Transportation. He is also a guest editor for the Journal of Computational Science, Neurocomputing, Swarm, and Evolutionary Computation and IEEE ITS Magazine.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"275829",title:"Dr.",name:"Esther",middleName:null,surname:"Villar-Rodriguez",slug:"esther-villar-rodriguez",fullName:"Esther Villar-Rodriguez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/275829/images/system/275829.jpg",biography:"Dr. Esther Villar obtained a Ph.D. in Information and Communication Technologies from the University of Alcalá, Spain, in 2015. She obtained a degree in Computer Science from the University of Deusto, Spain, in 2010, and an MSc in Computer Languages and Systems from the National University of Distance Education, Spain, in 2012. Her areas of interest and knowledge include natural language processing (NLP), detection of impersonation in social networks, semantic web, and machine learning. Dr. Esther Villar made several contributions at conferences and publishing in various journals in those fields. Currently, she is working within the OPTIMA (Optimization Modeling & Analytics) business of TECNALIA’s ICT Division as a data scientist in projects related to the prediction and optimization of management and industrial processes (resource planning, energy efficiency, etc).",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"49813",title:"Dr.",name:"Javier",middleName:null,surname:"Del Ser",slug:"javier-del-ser",fullName:"Javier Del Ser",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49813/images/system/49813.png",biography:"Prof. Dr. Javier Del Ser received his first PhD in Telecommunication Engineering (Cum Laude) from the University of Navarra, Spain, in 2006, and a second PhD in Computational Intelligence (Summa Cum Laude) from the University of Alcala, Spain, in 2013. He is currently a principal researcher in data analytics and optimisation at TECNALIA (Spain), a visiting fellow at the Basque Center for Applied Mathematics (BCAM) and a part-time lecturer at the University of the Basque Country (UPV/EHU). His research interests gravitate on the use of descriptive, prescriptive and predictive algorithms for data mining and optimization in a diverse range of application fields such as Energy, Transport, Telecommunications, Health and Industry, among others. In these fields he has published more than 240 articles, co-supervised 8 Ph.D. theses, edited 6 books, coauthored 7 patents and participated/led more than 40 research projects. He is a Senior Member of the IEEE, and a recipient of the Biscay Talent prize for his academic career.",institutionString:"Tecnalia Research & Innovation",institution:null},{id:"278948",title:"Dr.",name:"Carlos Pedro",middleName:null,surname:"Gonçalves",slug:"carlos-pedro-goncalves",fullName:"Carlos Pedro Gonçalves",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRcmyQAC/Profile_Picture_1564224512145",biography:'Carlos Pedro Gonçalves (PhD) is an Associate Professor at Lusophone University of Humanities and Technologies and a researcher on Complexity Sciences, Quantum Technologies, Artificial Intelligence, Strategic Studies, Studies in Intelligence and Security, FinTech and Financial Risk Modeling. He is also a progammer with programming experience in:\n\nA) Quantum Computing using Qiskit Python module and IBM Quantum Experience Platform, with software developed on the simulation of Quantum Artificial Neural Networks and Quantum Cybersecurity;\n\nB) Artificial Intelligence and Machine learning programming in Python;\n\nC) Artificial Intelligence, Multiagent Systems Modeling and System Dynamics Modeling in Netlogo, with models developed in the areas of Chaos Theory, Econophysics, Artificial Intelligence, Classical and Quantum Complex Systems Science, with the Econophysics models having been cited worldwide and incorporated in PhD programs by different Universities.\n\nReceived an Arctic Code Vault Contributor status by GitHub, due to having developed open source software preserved in the \\"Arctic Code Vault\\" for future generations (https://archiveprogram.github.com/arctic-vault/), with the Strategy Analyzer A.I. module for decision making support (based on his PhD thesis, used in his Classes on Decision Making and in Strategic Intelligence Consulting Activities) and QNeural Python Quantum Neural Network simulator also preserved in the \\"Arctic Code Vault\\", for access to these software modules see: https://github.com/cpgoncalves. He is also a peer reviewer with outsanding review status from Elsevier journals, including Physica A, Neurocomputing and Engineering Applications of Artificial Intelligence. Science CV available at: https://www.cienciavitae.pt//pt/8E1C-A8B3-78C5 and ORCID: https://orcid.org/0000-0002-0298-3974',institutionString:"University of Lisbon",institution:{name:"Universidade Lusófona",country:{name:"Portugal"}}},{id:"241400",title:"Prof.",name:"Mohammed",middleName:null,surname:"Bsiss",slug:"mohammed-bsiss",fullName:"Mohammed Bsiss",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/241400/images/8062_n.jpg",biography:null,institutionString:null,institution:null},{id:"276128",title:"Dr.",name:"Hira",middleName:null,surname:"Fatima",slug:"hira-fatima",fullName:"Hira Fatima",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/276128/images/14420_n.jpg",biography:"Dr. Hira Fatima\nAssistant Professor\nDepartment of Mathematics\nInstitute of Applied Science\nMangalayatan University, Aligarh\nMobile: no : 8532041179\nhirafatima2014@gmal.com\n\nDr. Hira Fatima has received his Ph.D. degree in pure Mathematics from Aligarh Muslim University, Aligarh India. Currently working as an Assistant Professor in the Department of Mathematics, Institute of Applied Science, Mangalayatan University, Aligarh. She taught so many courses of Mathematics of UG and PG level. Her research Area of Expertise is Functional Analysis & Sequence Spaces. She has been working on Ideal Convergence of double sequence. She has published 17 research papers in National and International Journals including Cogent Mathematics, Filomat, Journal of Intelligent and Fuzzy Systems, Advances in Difference Equations, Journal of Mathematical Analysis, Journal of Mathematical & Computer Science etc. She has also reviewed few research papers for the and international journals. She is a member of Indian Mathematical Society.",institutionString:null,institution:null},{id:"414880",title:"Dr.",name:"Maryam",middleName:null,surname:"Vatankhah",slug:"maryam-vatankhah",fullName:"Maryam Vatankhah",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Borough of Manhattan Community College",country:{name:"United States of America"}}},{id:"414879",title:"Prof.",name:"Mohammad-Reza",middleName:null,surname:"Akbarzadeh-Totonchi",slug:"mohammad-reza-akbarzadeh-totonchi",fullName:"Mohammad-Reza Akbarzadeh-Totonchi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Ferdowsi University of Mashhad",country:{name:"Iran"}}},{id:"414878",title:"Prof.",name:"Reza",middleName:null,surname:"Fazel-Rezai",slug:"reza-fazel-rezai",fullName:"Reza Fazel-Rezai",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"American Public University System",country:{name:"United States of America"}}},{id:"302698",title:"Dr.",name:"Yao",middleName:null,surname:"Shan",slug:"yao-shan",fullName:"Yao Shan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Dalian University of Technology",country:{name:"China"}}},{id:"125911",title:"Prof.",name:"Jia-Ching",middleName:null,surname:"Wang",slug:"jia-ching-wang",fullName:"Jia-Ching Wang",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"National Central University",country:{name:"Taiwan"}}},{id:"357085",title:"Mr.",name:"P. Mohan",middleName:null,surname:"Anand",slug:"p.-mohan-anand",fullName:"P. Mohan Anand",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Indian Institute of Technology Kanpur",country:{name:"India"}}},{id:"356696",title:"Ph.D. Student",name:"P.V.",middleName:null,surname:"Sai Charan",slug:"p.v.-sai-charan",fullName:"P.V. Sai Charan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Indian Institute of Technology Kanpur",country:{name:"India"}}},{id:"357086",title:"Prof.",name:"Sandeep K.",middleName:null,surname:"Shukla",slug:"sandeep-k.-shukla",fullName:"Sandeep K. Shukla",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Indian Institute of Technology Kanpur",country:{name:"India"}}},{id:"356823",title:"MSc.",name:"Seonghee",middleName:null,surname:"Min",slug:"seonghee-min",fullName:"Seonghee Min",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Daegu University",country:{name:"Korea, South"}}},{id:"353307",title:"Prof.",name:"Yoosoo",middleName:null,surname:"Oh",slug:"yoosoo-oh",fullName:"Yoosoo Oh",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:"Yoosoo Oh received his Bachelor's degree in the Department of Electronics and Engineering from Kyungpook National University in 2002. He obtained his Master’s degree in the Department of Information and Communications from Gwangju Institute of Science and Technology (GIST) in 2003. In 2010, he received his Ph.D. degree in the School of Information and Mechatronics from GIST. In the meantime, he was an executed team leader at Culture Technology Institute, GIST, 2010-2012. In 2011, he worked at Lancaster University, the UK as a visiting scholar. In September 2012, he joined Daegu University, where he is currently an associate professor in the School of ICT Conver, Daegu University. Also, he served as the Board of Directors of KSIIS since 2019, and HCI Korea since 2016. From 2017~2019, he worked as a center director of the Mixed Reality Convergence Research Center at Daegu University. From 2015-2017, He worked as a director in the Enterprise Supporting Office of LINC Project Group, Daegu University. His research interests include Activity Fusion & Reasoning, Machine Learning, Context-aware Middleware, Human-Computer Interaction, etc.",institutionString:null,institution:{name:"Daegu Gyeongbuk Institute of Science and Technology",country:{name:"Korea, South"}}},{id:"262719",title:"Dr.",name:"Esma",middleName:null,surname:"Ergüner Özkoç",slug:"esma-erguner-ozkoc",fullName:"Esma Ergüner Özkoç",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Başkent University",country:{name:"Turkey"}}},{id:"346530",title:"Dr.",name:"Ibrahim",middleName:null,surname:"Kaya",slug:"ibrahim-kaya",fullName:"Ibrahim Kaya",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Izmir Kâtip Çelebi University",country:{name:"Turkey"}}},{id:"419199",title:"Dr.",name:"Qun",middleName:null,surname:"Yang",slug:"qun-yang",fullName:"Qun Yang",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Auckland",country:{name:"New Zealand"}}},{id:"351158",title:"Prof.",name:"David W.",middleName:null,surname:"Anderson",slug:"david-w.-anderson",fullName:"David W. Anderson",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Calgary",country:{name:"Canada"}}}]}},subseries:{item:{id:"86",type:"subseries",title:"Business and Management",keywords:"Demographic shifts, Innovation, Technology, Next-gen leaders, Worldwide environmental issues and clean technology, Uncertainty and political risks, Radical adjacency, Emergence of new business ecosystem type, Emergence of different leader and leader values types, Universal connector, Elastic enterprise, Business platform, Supply chain complexity",scope:"
\r\n\tThe Business and Management series topic focuses on the most pressing issues confronting organizations today and in the future. Businesses are trying to figure out how to lead in a time of global uncertainty. In emerging markets, issues such as ill-defined or unstable policies, as well as corrupt practices, can be hugely problematic. Changes in governments can result in new policy, regulations, and interest rates, all of which can be detrimental to foreign businesses and investments. A growing trend towards economic nationalism also makes the current global political landscape potentially hostile towards international businesses.
\r\n
\r\n\tThe demographic shifts are creating interesting challenges. People are living longer, resulting to an aging demographic. We have a large population of older workers and retirees who are living longer lives, combined with a declining birthrate in most parts of the world. Businesses of all types are looking at how technology is affecting their operations. Several questions arise, such as: How is technology changing what we do? How is it transforming us internally, how is it influencing our clients and our business strategy? It is about leveraging technology to improve efficiency, connect with customers more effectively, and drive innovation. The majority of innovative companies are technology-driven businesses. Realizing digital transformation is today’s top issue and will remain so for the next five years. Improving organizational agility, expanding portfolios of products and services, creating, and maintaining a culture of innovation, and developing next -generation leaders were also identified as top challenges in terms of both current and future issues.
\r\n
\r\n\tThe most sustained profitable growth occurs when a company expands its core business into an adjacent space. This has significant implications for management because innovation in business ecosystems differs from traditional, vertically integrated firms. Every organization in the ecosystem must be aware of the bigger picture. Innovation in ecosystems necessitates collaborative action to invent and appraise, efficient, cross-organizational knowledge flows, modular architectures, and good stewardship of legacy systems. It is built on multiple, interconnected platforms. Environmental factors have already had a significant impact in the West and will continue to have an impact globally. Businesses must take into account the environmental impact of their daily operations. The advantage of this market is that it is expected to grow more rapidly than the overall economy. Another significant challenge is preparing the next generation of leaders to elevate this to the number one priority within the next five years. There can be no culture of innovation unless there is diverse leadership or development of the next generation of leaders; and these diverse, next-generation leaders are the ones who will truly understand the digital strategies that will drive digital transformation.
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