Etiologic classification of orbital tumors causing secondary glaucoma.
\\n\\n
More than half of the publishers listed alongside IntechOpen (18 out of 30) are Social Science and Humanities publishers. IntechOpen is an exception to this as a leader in not only Open Access content but Open Access content across all scientific disciplines, including Physical Sciences, Engineering and Technology, Health Sciences, Life Science, and Social Sciences and Humanities.
\\n\\nOur breakdown of titles published demonstrates this with 47% PET, 31% HS, 18% LS, and 4% SSH books published.
\\n\\n“Even though ItechOpen has shown the potential of sci-tech books using an OA approach,” other publishers “have shown little interest in OA books.”
\\n\\nAdditionally, each book published by IntechOpen contains original content and research findings.
\\n\\nWe are honored to be among such prestigious publishers and we hope to continue to spearhead that growth in our quest to promote Open Access as a true pioneer in OA book publishing.
\\n\\n\\n\\n
\\n"}]',published:!0,mainMedia:{caption:"IntechOpen Maintains",originalUrl:"/media/original/113"}},components:[{type:"htmlEditorComponent",content:'
Simba Information has released its Open Access Book Publishing 2020 - 2024 report and has again identified IntechOpen as the world’s largest Open Access book publisher by title count.
\n\nSimba Information is a leading provider for market intelligence and forecasts in the media and publishing industry. The report, published every year, provides an overview and financial outlook for the global professional e-book publishing market.
\n\nIntechOpen, De Gruyter, and Frontiers are the largest OA book publishers by title count, with IntechOpen coming in at first place with 5,101 OA books published, a good 1,782 titles ahead of the nearest competitor.
\n\nSince the first Open Access Book Publishing report published in 2016, IntechOpen has held the top stop each year.
\n\n\n\nMore than half of the publishers listed alongside IntechOpen (18 out of 30) are Social Science and Humanities publishers. IntechOpen is an exception to this as a leader in not only Open Access content but Open Access content across all scientific disciplines, including Physical Sciences, Engineering and Technology, Health Sciences, Life Science, and Social Sciences and Humanities.
\n\nOur breakdown of titles published demonstrates this with 47% PET, 31% HS, 18% LS, and 4% SSH books published.
\n\n“Even though ItechOpen has shown the potential of sci-tech books using an OA approach,” other publishers “have shown little interest in OA books.”
\n\nAdditionally, each book published by IntechOpen contains original content and research findings.
\n\nWe are honored to be among such prestigious publishers and we hope to continue to spearhead that growth in our quest to promote Open Access as a true pioneer in OA book publishing.
\n\n\n\n
\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"8357",leadTitle:null,fullTitle:"Organic Polymers",title:"Organic Polymers",subtitle:null,reviewType:"peer-reviewed",abstract:"This book, Organic Polymers, covers aspects that are of immediate concern to a new entrant to the field of polymers. Taken as a whole, these eight chapters aim to help the readers easily assimilate other specialized and exhaustive treatises on the subject. Topics dealing with the chemistry and technology of polymers are presented in a careful and logical manner so as to provide an easy and enjoyable read. Several examples and analogies are included so to make the main concepts easy to follow and tables and figures are included so that the book can serve, to a limited extent, as a hand book dealing with polysaccharides with different parameters. This book is meant for students studying polysaccharides and those working on graft copolymers and other allied polymer industries but without a formal educational background in organic polymers.",isbn:"978-1-78984-618-8",printIsbn:"978-1-78984-573-0",pdfIsbn:"978-1-78985-194-6",doi:"10.5772/intechopen.78486",price:119,priceEur:129,priceUsd:155,slug:"organic-polymers",numberOfPages:146,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"ff2ffd663fed5810f0d78bf8487ade97",bookSignature:"Arpit Sand and Elsayed Zaki",publishedDate:"March 11th 2020",coverURL:"https://cdn.intechopen.com/books/images_new/8357.jpg",numberOfDownloads:10192,numberOfWosCitations:12,numberOfCrossrefCitations:19,numberOfCrossrefCitationsByBook:1,numberOfDimensionsCitations:50,numberOfDimensionsCitationsByBook:1,hasAltmetrics:0,numberOfTotalCitations:81,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"June 13th 2018",dateEndSecondStepPublish:"September 4th 2018",dateEndThirdStepPublish:"November 3rd 2018",dateEndFourthStepPublish:"January 22nd 2019",dateEndFifthStepPublish:"March 23rd 2019",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6,7",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"202274",title:"Associate Prof.",name:"Arpit",middleName:null,surname:"Sand",slug:"arpit-sand",fullName:"Arpit Sand",profilePictureURL:"https://mts.intechopen.com/storage/users/202274/images/system/202274.jpeg",biography:"Dr Arpit Sand is currently an Associate Professor in the Department of Chemistry at Manav Rachna University, India, a\nposition he has held since 2014. He received his B.Sc. in Science\nand his M.Sc. in Chemistry from the University of Allahabad,\nIndia, in 2004 and 2006, respectively. He received his Ph.D.\ndegree in Chemistry from the University of Allahabad in 2010.\nDr Arpit Sand is a reviewer for international journals including\nCarbohydrate Polymers, the International Journal of Biological Macromolecules,\nFibers and Polymers, etc. He is also a life member of the Indian Science Congress\nand the Green Chemistry Network centre, and he has authored more than 20 international research articles and review articles in reputed SCI journals. He has made\na significant contribution to the field of the modification and characterization of\ngraft copolymers. His research interests include polymer synthesis using different\npolymerization techniques.",institutionString:"Department of Chemistry, Manav Rachna University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"Manav Rachna International University",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:{id:"220156",title:"Dr.",name:"ElSayed G.",middleName:null,surname:"Zaki",slug:"elsayed-g.-zaki",fullName:"ElSayed G. Zaki",profilePictureURL:"https://mts.intechopen.com/storage/users/220156/images/system/220156.jpg",biography:"Dr. Elsayed Zaki received his Ph.D. in Physical Chemistry from the Department of Chemistry, Faculty of Science, Mansoura University, Egypt. Currently, he is a visiting researcher at the Department of Chemical and Biomolecular Engineering, Iacocca Hall, Lehigh University, Pennsylvania, USA. He is an Associate Professor of Applied Chemistry in the Petroleum Applications Department, Egyptian Petroleum Research Institute. He is currently an editorial board member for several reputed journals, a member of the Synchrotron-light for Experimental Science and Applications in the Middle East (SESAME), Organization for Women in Science for the Developing World (OWSD), and the International Union of Pure and Applied Chemistry (IUPAC).",institutionString:"Egyptian Petroleum Research Institute",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"Egyptian Petroleum Research Institute",institutionURL:null,country:{name:"Egypt"}}},coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"1415",title:"Polymer Chemistry",slug:"polymer-chemistry"}],chapters:[{id:"68396",title:"Introductory Chapter: Organic Polymer - Graft Copolymers",doi:"10.5772/intechopen.88037",slug:"introductory-chapter-organic-polymer-graft-copolymers",totalDownloads:803,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:null,signatures:"Arpit Sand and Aparna Vyas",downloadPdfUrl:"/chapter/pdf-download/68396",previewPdfUrl:"/chapter/pdf-preview/68396",authors:[{id:"202274",title:"Associate Prof.",name:"Arpit",surname:"Sand",slug:"arpit-sand",fullName:"Arpit Sand"},{id:"302309",title:"Dr.",name:"Aparna",surname:"Vyas",slug:"aparna-vyas",fullName:"Aparna Vyas"}],corrections:null},{id:"67226",title:"Rapid Evaluation of the Properties of Natural Rubber Latex and Its Products Using Near-Infrared Spectroscopy",doi:"10.5772/intechopen.84549",slug:"rapid-evaluation-of-the-properties-of-natural-rubber-latex-and-its-products-using-near-infrared-spec",totalDownloads:1605,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:1,abstract:"The parameters including physico-chemical properties such as dry rubber content (DRC), total solids content (TSC), volatile fatty acid (VFA) number, alkalinity (ammonia content) and potassium hydroxide (KOH) number and physical properties such as viscosity and cross-link density are important to the trading and processing of natural rubber latex and its products. Traditionally these properties of field and concentrated latices and their products including thin and thick films are evaluated with chemicals and time-consuming methods and with the need of technical experts. The near-infrared (NIR) spectroscopy is a nondestructive, rapid, accurate and environment-friendly technique. It needs no chemical. This chapter describes the application of NIR spectroscopy on evaluation of the properties of natural rubber latex and its products.",signatures:"Panmanas Sirisomboon and Chin Hock Lim",downloadPdfUrl:"/chapter/pdf-download/67226",previewPdfUrl:"/chapter/pdf-preview/67226",authors:[{id:"268630",title:"Ph.D.",name:"Panmanas",surname:"Sirisomboon",slug:"panmanas-sirisomboon",fullName:"Panmanas Sirisomboon"},{id:"268634",title:"Mr.",name:"Chin Hock",surname:"Lim",slug:"chin-hock-lim",fullName:"Chin Hock Lim"}],corrections:null},{id:"67172",title:"Electron Donor-Acceptor Organic Polymers by “Click” Type Cycloaddition/Retroelectrocyclization Reaction",doi:"10.5772/intechopen.85775",slug:"electron-donor-acceptor-organic-polymers-by-click-type-cycloaddition-retroelectrocyclization-reactio",totalDownloads:891,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"The “click” type cycloaddition/retroelectrocyclization reaction is an intriguing approach for synthesizing electron donor-acceptor organic polymers. This chapter covers the fundamental reaction mechanism and the basic principles of applying this reaction to the synthesis of organic polymers via postfunctionalization or step-growth polymerization. The electron donor-acceptor moieties can be incorporated into the main-chain and/or side-chain of both conjugated and nonconjugated polymers. These polymers feature attractive properties including intramolecular charge-transfer bands, nonlinear optical properties, redox activities, third-order nonlinear optical properties, and enhanced thermal stability. Because of this, these polymers have found a variety of applications such as colorimetric chemosensors of metal ions, nonlinear optics, and solar cells. This novel “click” chemistry paves a unique path toward the synthesis of next-generation functional materials that cannot be accomplished by the incumbent synthetic methods.",signatures:"Wenyi Huang",downloadPdfUrl:"/chapter/pdf-download/67172",previewPdfUrl:"/chapter/pdf-preview/67172",authors:[{id:"264605",title:"Ph.D.",name:"Wenyi",surname:"Huang",slug:"wenyi-huang",fullName:"Wenyi Huang"}],corrections:null},{id:"65706",title:"Application of Organic Coagulants in Water and Wastewater Treatment",doi:"10.5772/intechopen.84556",slug:"application-of-organic-coagulants-in-water-and-wastewater-treatment",totalDownloads:3633,totalCrossrefCites:13,totalDimensionsCites:38,hasAltmetrics:0,abstract:"Coagulation is an essential mechanism that occurs in most conventional water and wastewater treatment plants. This occurs in a physical purification unit involving transport processes and the addition of coagulants for chemical reactions, charge neutralization, and formation of smaller flocs to agglomerate into larger flocs. This enhances the effective removal of recalcitrant contaminants by downstream processes. However, poor treatment of wastewater might have a high negative impact on biodiversity and the environment in general. This chapter seeks to address the limitation of employing inorganic coagulants by evaluating the efficiency of organic coagulants and exploring the factors and mechanism governing coagulation in a physiochemical treatment process of water and wastewater resources. The effect of pH, coagulant type and dosage to ease the high sludge production and discharge of residual metals into the downstream waters is addressed. The emerging of organic coagulants and technology to mitigate the performance and recovery of mineral coagulants from wastewater treatment residual is been proposed.",signatures:"Emmanuel Kweinor Tetteh and Sudesh Rathilal",downloadPdfUrl:"/chapter/pdf-download/65706",previewPdfUrl:"/chapter/pdf-preview/65706",authors:[{id:"199957",title:"Dr.",name:"Sudesh",surname:"Rathilal",slug:"sudesh-rathilal",fullName:"Sudesh Rathilal"},{id:"262983",title:"Dr.",name:"Emmanuel",surname:"Kweinor Tetteh",slug:"emmanuel-kweinor-tetteh",fullName:"Emmanuel Kweinor Tetteh"}],corrections:null},{id:"65674",title:"Directed Self-Assembly of Block Copolymers Based on the Heterogeneous Nucleation Process",doi:"10.5772/intechopen.84468",slug:"directed-self-assembly-of-block-copolymers-based-on-the-heterogeneous-nucleation-process",totalDownloads:717,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"By introducing the heterogeneous nucleation concept to directed self-assembly of block copolymers, the ordering of dynamical process and defect pattern design in thin films of binary blend, AB diblock/C homopolymer (AB/C), are investigated by the time-dependent Ginzburg-Landau theory and simulated by the cell dynamics simulations. The detailed annealing process of a few isolated defects occurring in AB/C blend under triangular and hexagonal confinements is presented, and it indicates that angle-matched confinement of triangular and hexagonal potential well is favorable conditions for generating defect-free ordered structures. Meanwhile, we gave a model which composed of many double-spot potentials with controllable position and orientation to investigate the relationship between defect spacing and mismatched angle, and we found the relationship is similar to hard crystals. Additionally, as an example, the design of defect pattern of “NXU” for abbreviation of Ningxia University is proposed and tested. In this chapter, the feasibility of directed self-assembly of block copolymers based on the heterogeneous nucleation process is systematically confirmed.",signatures:"Rui Lu, Xiaobing Qu, Lu Zhang, Nana Zhu and Tao Yang",downloadPdfUrl:"/chapter/pdf-download/65674",previewPdfUrl:"/chapter/pdf-preview/65674",authors:[{id:"287953",title:"Dr.",name:"Tao",surname:"Yang",slug:"tao-yang",fullName:"Tao Yang"},{id:"316422",title:"Dr.",name:"Rui",surname:"Lu",slug:"rui-lu",fullName:"Rui Lu"},{id:"316423",title:"Dr.",name:"Xiaobing",surname:"Qu",slug:"xiaobing-qu",fullName:"Xiaobing Qu"},{id:"316424",title:"Dr.",name:"Lu",surname:"Zhang",slug:"lu-zhang",fullName:"Lu Zhang"},{id:"316425",title:"Dr.",name:"Nana",surname:"Zhu",slug:"nana-zhu",fullName:"Nana Zhu"}],corrections:null},{id:"69528",title:"New Methods in the Synthesis of (Meth)Acrylates",doi:"10.5772/intechopen.89767",slug:"new-methods-in-the-synthesis-of-meth-acrylates",totalDownloads:648,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Generally, the words “reactive polymers” and “functional polymers” mean the same thing and are used interchangeably in most studies and describe cross-linked (insoluble) bead-structured resins containing chemically reactive functional groups. In this way, reactive polymers are widely used as polymeric reagents or polymer supports in biochemical and chemical applications. Functional (meth)acrylates referred here to supply “functional esters” ruins as a general reactive group precursor. In other sense, the leaving (activating) groups of these monomers may easily react with the alcohols and amines carrying the desired reactive groups and therefore, in general, provide a single reaction step for the synthesis of reactive polymers. In this paper, we suggest new routes for a new (meth)acrylate-based monomers and polymers. Also, the synthesis of a serial new (meth)acrylate esters including amide, dioxolane, benzofuran, and chalcone groups is described.",signatures:"Cengiz Soykan",downloadPdfUrl:"/chapter/pdf-download/69528",previewPdfUrl:"/chapter/pdf-preview/69528",authors:[{id:"295591",title:"Prof.",name:"Cengiz",surname:"Soykan",slug:"cengiz-soykan",fullName:"Cengiz Soykan"}],corrections:null},{id:"69280",title:"Biodegradable Polymers: Opportunities and Challenges",doi:"10.5772/intechopen.88146",slug:"biodegradable-polymers-opportunities-and-challenges",totalDownloads:965,totalCrossrefCites:2,totalDimensionsCites:6,hasAltmetrics:0,abstract:"The overuse of polymer materials from fossil sources has generated a large volume of waste that causes environmental impacts due to the degradation time. The technological advance has stimulated the search for alternatives that can contribute to sustainability. In this context, the use of biodegradable polymers, that use raw materials from renewable sources stand out because they have that ability to form films and come from abundant sources. Also, in the expectation of optimizing the environmental benefits in this process, it is possible to value the agroindustrial residues, using them as raw material in the synthesis of the polymer, the physical, chemical and mechanical properties of these polymers are important to evaluate the possible applications. The proposal of this chapter is to present current research on renewable sources, including agricultural and industrial residues, to obtain biodegradable polymers, highlighting their properties and possibilities of application.",signatures:"Marieli Rosseto, Cesar V.T. Rigueto, Daniela D.C. Krein, Naiana P. Balbé, Lillian A. Massuda and Aline Dettmer",downloadPdfUrl:"/chapter/pdf-download/69280",previewPdfUrl:"/chapter/pdf-preview/69280",authors:[{id:"302139",title:"Prof.",name:"Aline",surname:"Dettmer",slug:"aline-dettmer",fullName:"Aline Dettmer"},{id:"308026",title:"Mr.",name:"Cesar V.T.",surname:"Rigueto",slug:"cesar-v.t.-rigueto",fullName:"Cesar V.T. Rigueto"},{id:"308394",title:"Ms.",name:"Marieli",surname:"Rosseto",slug:"marieli-rosseto",fullName:"Marieli Rosseto"},{id:"308395",title:"Ms.",name:"Daniela D.C.",surname:"Krein",slug:"daniela-d.c.-krein",fullName:"Daniela D.C. Krein"},{id:"308396",title:"Ms.",name:"Naiana P.",surname:"Balbé",slug:"naiana-p.-balbe",fullName:"Naiana P. Balbé"},{id:"308398",title:"Ms.",name:"Lillian A.",surname:"Massuda",slug:"lillian-a.-massuda",fullName:"Lillian A. Massuda"}],corrections:null},{id:"67521",title:"Lignin as Sustainable Antimicrobial Fillers to Develop PET Multifilaments by Melting Process",doi:"10.5772/intechopen.86634",slug:"lignin-as-sustainable-antimicrobial-fillers-to-develop-pet-multifilaments-by-melting-process",totalDownloads:931,totalCrossrefCites:2,totalDimensionsCites:3,hasAltmetrics:0,abstract:"Nowadays, textiles functionalization is developing increasingly, fabrics are not only defined by the intrinsic properties of the fiber but some properties are also brought to provide them added value. Among the desired properties, antibacterial activity is targeted to improve the comfort and durability of textiles but many commercial products use chemical substances which are harmful for the environment (regulation 528/2012). The goal of this study was to use bio-based biocide which can be incorporated in the polyethylene terephthalate (PET) by melt spinning for the development of functional PET. This biocide had to resist to the PET processing temperature up to 264°C which was the maximum temperature of implementation. Two kinds of Kraft lignin and titanium dioxide as reference were added by melting way. The antimicrobial activity was characterized at low concentration (1 and 2 wt.%), to avoid a significant decrease in mechanical strength for the multifilaments and to maintain optimal rheological properties of the polymer for the melt spinning process. Filled PET pellets were obtained by twin screw extrusion step and the multifilaments by melt spinning step. Finally, knitting structures were developed for the evaluation of the antibacterial activity. The mechanical (tensile test) and thermal (DSC and TGA) properties of the filaments were characterized.",signatures:"Juliette Minet, Aurélie Cayla and Christine Campagne",downloadPdfUrl:"/chapter/pdf-download/67521",previewPdfUrl:"/chapter/pdf-preview/67521",authors:[{id:"229606",title:"Dr.",name:"Aurélie",surname:"Cayla",slug:"aurelie-cayla",fullName:"Aurélie Cayla"},{id:"303114",title:"Prof.",name:"Christine",surname:"Campagne",slug:"christine-campagne",fullName:"Christine Campagne"},{id:"303115",title:"Mrs.",name:"Juliette",surname:"Minet",slug:"juliette-minet",fullName:"Juliette Minet"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"7363",title:"Cellulose",subtitle:null,isOpenForSubmission:!1,hash:"ed333d89928591f1a4b2710130fddee3",slug:"cellulose",bookSignature:"Alejandro Rodríguez Pascual and María E. 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\r\n\tMedicinal herbs and culinary spices are very important sources of bioactive compounds for different kinds of industries. They accompany a person's life from birth to grave almost every day, in various forms is, served to our table as a part of the food. Many plants are necessary for technical and bioenergetic purposes, and a large group of plants is used in medicine, pharmacy, cosmetics as well as in folk medicine, and gastronomy. Approximately one thousand types of medicinal plants grow in Europe – about 800 are used in folk medicine, more than 300 in European officinal medicine. Nowadays, people have started to be more interesting in this kind of plant due to the benefits. The style "return back to tradition" is one of the more popular trends. The aim of this book is brought to information about medicinal herbs and spices – botany characteristics, chemical components, and the possibility of use in different kinds of industries.
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Awards: 2011 – Rector's Award for best student; 2015 and 2019, 2020 – Dean's Award for the Best of publication activity. Under her leadership, 29 Bachelors and 55 diplomats successfully defended their work. She is a member of the international network AgroBioNet; Member of EFSA; CASEE; Member of Evaluation Commission for Start-up projects EIT Food Hub; Member of Examining Commissions for State Examinations; member of scientific committees of international conferences \"Meeting of Young Researches from V4 Countries\", University of Rzeszow, Poland. She is a head of graduation commission in secondary school in Nitra (SOŠ Slančíková Nitra). She is a reviewer of the journals – Natural Product Research (IF 1.999), Journal of Food Science (IF 2.478), Acta Scientiarum Polonorum Technologia Alimentaria, Journal of Agricultural Science and Technology, BMC Complementary Medicine and Therapies (IF 2.833), Food Chemistry (IF 6.306), Journal of Food Science and Technology (IF 1.849), SN Applied Sciences, RSC Advances (IF 3.070), PLoS One (2.740), Open Life Sciences (IF 0.690), Journal of Microbiology, Biotechnology and Food Sciences, Journal of Central European Agriculture et al.",institutionString:"Slovak University of Agriculture",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"Slovak University of Agriculture",institutionURL:null,country:{name:"Slovakia"}}}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"5",title:"Agricultural and Biological Sciences",slug:"agricultural-and-biological-sciences"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"478197",firstName:"Veronika",lastName:"Radosavac",middleName:null,title:"Dr.",imageUrl:"//cdnintech.com/web/frontend/www/assets/author.svg",email:"veronika@intechopen.com",biography:null}},relatedBooks:[{type:"book",id:"6418",title:"Hyperspectral Imaging in Agriculture, Food and Environment",subtitle:null,isOpenForSubmission:!1,hash:"9005c36534a5dc065577a011aea13d4d",slug:"hyperspectral-imaging-in-agriculture-food-and-environment",bookSignature:"Alejandro Isabel Luna Maldonado, Humberto Rodríguez Fuentes and Juan Antonio Vidales Contreras",coverURL:"https://cdn.intechopen.com/books/images_new/6418.jpg",editedByType:"Edited by",editors:[{id:"105774",title:"Prof.",name:"Alejandro Isabel",surname:"Luna Maldonado",slug:"alejandro-isabel-luna-maldonado",fullName:"Alejandro Isabel Luna Maldonado"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10359",title:"Landraces",subtitle:"Traditional Variety and Natural Breed",isOpenForSubmission:!1,hash:"0600836fb2c422f7b624363d1e854f68",slug:"landraces-traditional-variety-and-natural-breed",bookSignature:"Amr Elkelish",coverURL:"https://cdn.intechopen.com/books/images_new/10359.jpg",editedByType:"Edited by",editors:[{id:"231337",title:"Dr.",name:"Amr",surname:"Elkelish",slug:"amr-elkelish",fullName:"Amr Elkelish"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. 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Today, because of environmental concerns, shielded solid dielectric cables are used more and more and most new power cables installed are solid dielectric cables. Figure 1 [1] shows the structure of a typical high-voltage shielded dielectric power cable. The conductor core F is the part that delivers power. The conductor shields C and E help smooth the electric field between the conductor and the insulation materials. The dielectric or insulation D is used to insulate high-voltage core F from the ground, i.e. neutral wires B. Encapsulating jacket A prevents water and dust from getting into the cable.
A typical high-voltage extruded solid dielectric cable. A, encapsulating jacket; B, neutral wires; C, ground shield; D, dielectric; E, conductor shield; F, conductor; the conductor shield and ground shield are semiconductive. Usually, they are made by adding carbon black into a polymer and the particle size of the carbon black ranges from 15 to 50 nm. The basic function of this configuration is to confine the electric field within the cable and obtain a symmetrical radial distribution of the electric within the dielectric [
Most failures occurring in the shielded dielectric cables are related to partial discharge. Partial discharges are localized breakdowns in a small portion of the insulations, which can be solid or fluid electrical insulation. When high voltage is applied to high-voltage equipment, defects introduced during the manufacturing process such as contained insulation cracks, contained insulation surfaces, or voids can all lead to partial discharges. In some cases, even without any defects, aging can cause the degradation of the insulator leading to partial discharges. PD makes damage to the equipment, and equipment with PD occurring within will eventually fail after a certain time depending on the strength of the PD if proper treatments are not applied. It’s important to monitor partial discharges in high-voltage systems and if PD is detected, appropriate actions should be taken to prevent sudden failures, which can cause big blackouts.
Figure 2 gives us some basic ideas on how partial discharges occur. The cavity in the insulation normal contains gas which could be ionized when the electrical field exceeds the cutoff strength. When this happens, electromagnetic waves in the radiofrequencies are generated along with light, heat, noise, and possibly gas. With appropriate technologies and by detecting the HF radio signals, the magnitude as well as the location of partial discharges can be identified and used for assessing the health status of the shielded dielectric cable.
A “typical” partial discharge mechanism. The cavity in the insulation normally contains gas, which could be ionized when the electrical field exceeds the cutoff strength.
As discussed above, PD can create high-frequency electromagnetic waves in the radiofrequencies, heat, light, gas, etc. A lot of research has been conducted to study for detecting PD using sensors for heat, light, gas, etc. In this chapter, we focus on radiofrequency high-frequency PD signal detection as it provides a way to detect PD over long distances, which makes it useful in many cases. To effectively detect and analyze PD, first we have to understand the PD pulse. The authors will analyze the PD pulse spectrums, frequency properties, etc. Note that PD occurring in different high-voltage apparatus varies significantly due to the insulation properties and electric stress needed for triggering PD. Since this chapter focuses on PD in shielded dielectric cables, we will focus on the PD pulse properties in shielded dielectric cables.
Because the formation of electron avalanches is within the nanosecond range, the PD event is associated with a very fast current pulse. As of today, there is no direct way to measure the PD current pulse. A lot of theories have been proposed to simulate and study the current pulse and different measuring techniques were developed to measure PD current pulses. The PD is caused by the flow of the electrons and ions. The moving speed of the electrons is much faster than the ions. Some early theoretical simulations [2–5] predicted that the pulse current in the voids of the shielded dielectric cables has a rising time and pulse widths in the nanosecond range followed by a long-duration, low-magnitude pulse. Figure 3 shows one theoretically predicted PD current pulse. With the high-speed oscilloscope available, some PD experiments were conducted by Fujimoto and Boggs (1981) and Boggs and Stone (1982) [4] and the experimental results agree with the theoretical simulation results.
One theoretically predicted PD current pulse [
There is no standard spectrum chart for PD pulses in the power cables because under different situations, the PD pulse can be in different shapes leading to different energy spectrums. Some experimental results [6] show that the partial discharge spectrum has a peak point at about 100 MHz when measuring PD at a distance very close to the PD source. When the partial discharge pulse propagates in the high-voltage cable, its high-frequency components are attenuated by the losses majorly caused by the semiconducting materials and, after a 100-meter trip, the peak frequency of the spectrum can be reduced to 20–30 MHz.
When the electromagnetic PD wave propagates in the cable, its HF components are significantly attenuated by the shielded cables. How far the pulse can travel and be detected by the PD detection devices heavily relies on the attenuation properties of the cable. A lot of research [7–17] has been conducted to study different aspects of the HF attenuation features of the shielded dielectric cables. From Figure 1, the HF attenuation is caused by various components. One measurement result [9] shown in Figure 4 gives HF attenuation losses for different components for different frequencies. From Figure 4, it can be seen that for this measurement, conductor and neutral wire skin effect losses dominate for low frequencies up to 5 MHz. After 5 MHz, grounding shielding losses as well as the dielectric losses start to play a more important role. This can be explained by the fact that at low frequencies, the capacitive current is low thus the current passing through the dielectric, conductor and ground shielding is low leading to relatively low losses. When frequencies are higher, the larger capacitive current flowing through the resistive component of the conductor and ground shielding makes big losses.
Measurement results for one shielded cable [
From the above analysis, it can be seen that the dielectric properties of the shielding are critical to HF losses of the shielding dielectric cables. The dielectric properties of the cable semiconducting shielding can be measured by a HF impedance analyzer. Figure 5 [10 and 17] shows a typical measurement configuration for HF dielectric properties (dielectric constant and conductivity) of the cable shielding. Conducting electrodes with small surface resistivity, often metal paint, are applied to the two surfaces of the shield material. Normally, contact with the electrodes is made along one edge of the sample. There is a voltage drop across the “conducting” electrodes, which can cause errors in the dielectric properties measurement when the current flowing through the sample and the nonperfect electrode resulting in possible measurement errors.
Typical measurement method for HF dielectric properties of the cable shielding and a simplified sample geometry and lumped element representation [
The measured sample impedance is normally interpreted as resulting from the dielectric constant and conductivity of the sample if we assume that the losses and voltage drop in the electrodes are negligible [7 and 10]. The applied electrode has a finite conductivity (normal silver paint) resulting in changes in the measured loss leading to errors in predicting the shield properties. These errors increase with frequency because the current through the electrodes increase significantly with frequency as a result of the large dielectric constant of the shield material. If we assume that voltage is applied along one edge of the upper and lower surface of a rectangular sample, as shown in Figure 5, and define
where
and
From Eq. 2, it can be seen that the power losses
where
The measured ground shield relative dielectric constant and conductivity for a shielded power cable.
From Figure 4, there are losses from different components of the shielded power cable. The losses come from insulation, skin effect, conduct shield, and ground shield. For high frequencies (5–20 MHz), the loss in the ground shield could dominate the shield cable loss [11,12]. This chapter discusses the loss calculations in the ground shield as it dominates losses at high frequency, which is critical for HF PD pulse propagation, detection and analysis. The shielded power cable can have different geometries, configurations, and number of neutral wires. The chapter won’t cover all cable configurations. Two typical shielded cables will be studied.
The conductor and ground shield layers of shielded distribution cables help provide a smooth interface between conductors and insulation. Since the losses caused by the conductor shield are pretty small compared to the losses in other components, these losses are sometimes ignored in analyses. Figure 7 shows a typical jacketed shielded cable geometry and its simplified computation model [11 and 17]. The current flows from the conductor through the insulation (dielectric) passing through the ground semiconducting shield before it reaches the neutral, resulting in big losses in the shield at high frequency. The current passing through the ground shield is determined by the conductor voltage level and dielectric impedance, and can be considered as a “current source.”
A typical jacketed shielded cable geometry and its simplified computation model [
The loss caused by the current in the ground shield, including the component caused by the propagation of the current in a circumferential direction to reach a neutral wire, can be calculated with known cable parameters.
With this simplified model, the ground shield current and voltage distributions of such a system can be derived [11 and 17]:
where
and similarly, the current passing through the resistive component of the conductor shield can be found as
With these two currents known, the losses in the conductor and ground shields can be found by calculating the power dissipation, i.e. the product of
The losses in the ground shield with some typical parameters (neutral wire conductor radius of 4 mm, dielectric thickness of 7 mm, conductor shield thickness of 0.2 mm, and ground shield thickness of 0.5 mm, the relative dielectric constant of 200, and conductivity of 0.1 S/m) can be seen in Figure 8 for a different number of neutral wires. Finite analysis element calculations are also conducted and the results of which are compared with the analytic results. They agree with each other well.
Losses in the ground shield for different numbers of neutral wires [11 and 17]. Finite analysis element calculations are also conducted and the results of which are compared with the analytic results. They agree with each other well.
To give the reader a better idea on the total HF losses in the shielded power cable, one more plot is given in Figure 9 for a cable with six neutral wires [11 and 17]. From Figure 9, it can be seen that for high frequencies (from 5 to 20 MHz), the ground shield loss, including the losses caused by the interaction of the ground shield with the neutral wires, dominates the HF loss for this six neutral-wire cable. The interaction of the neutral wires with the ground shield plays a critical role for the total loss, as can be seen by comparison with the line showing the ground shield loss with and without the effect of the circumferential current.
The total losses in a cable with six neutral wires. The losses from the current flowing through the ground losses contribute significantly to the total loss.
To save costs, sometimes, unjacketed cables are installed. A cable jacket ensures intimate contact between ground shield and neutral wires. For unjacketed cables, this contact is not ensured resulting in the loss caused by the ground shield as a function of the separation between the neutral wires and the ground shield and the distance between points of contact of the neutral wires with the ground shield [13]. This section will address the loss as a function of neutral wire separation from the ground shield, contact interval between the neutral wires, ground shield dielectric properties, frequency, etc. Figure 10 [13] gives a simplified model for the unjacketed cable.
A simplified model for the unjacketed cable. Due to the nature of unjacketed cables, the neutral wires only have contacts with certain points, A, B and C.
Due to the nature of unjacketed cables, the neutral wires only have contacts with certain points, A, B, and C. Similar to a normal jacketed cable, the current flowing through resistive component of the ground shield leads to loss that dominates the loss for high frequencies. The voltage and current distributions as well as the current passing through the resistive component of such a system can be found as [13]
Similarly to a normal jacketed cable, the losses can be found by integrating the product of the resistive current and the resistance. The Maple program is similar to the normal jacketed shield cable and can be found in paper [13], and thus is not given in this chapter. The ground shield losses in the unjacketed cable, which dominates the HF loss, can vary a lot for different shield dielectric constants, conductivity, and thickness of the ground shield. The thickness of the ground shield plays an important role because the displacement current from the conductor to the ground shield flows longitudinally through the resistance of the ground shield before it reaches a neutral wire-ground shield contact. This loss is maximized under the condition that the resistive impedance of this path is comparable to the capacitive impedance of the dielectric, which is significantly affected by the thickness of the ground shield. For a typical ground shield thickness of 1 mm, and conductor radius, 3.62 mm; insulation thickness, 4.83 mm; capacitance between ground shield and neutral wires, 150 pF/m; insulation dielectric constant, 2.2; distance between two neutral wire-ground shield contacts, 3 cm; frequency, 20 MHz, the loss of such a jacketed cable vs. dielectric constant and conductivity is shown in Figure 11 [13]. From Figure 11, it can be seen that the losses can be pretty large due to the long distance needed for the displacement current to flow before it reaches the neutral wires, which means that the HF electromagnetic PD wave can be attenuated significantly in the unjacketed cable.
As stated at the beginning of this section, shield cables have different geometries and configurations. The authors won’t address too many configurations and only two typical shielded cables, i.e. jacketed normal shielded cable and unjacketed shielded cables, are studied in this section. The reader should keep in mind that when designing and analyzing the HF electromagnetic PD wave signals, it’s very important to know the shield dielectric properties and cable actual geometry and configurations to get a rough idea of the cable’s HF attenuation properties. The readers should also know that it’s not easy to do the HF dielectric property measurements and use caution when conducting such measurements. Furthermore, the reader needs to know that the shields in the cables are under pressure whereas the shields under test have no pressure. Some compensation might be necessary to offset the pressure difference.
Losses vs. dielectric constant and conductivity for typical parameters.
The HF electromagnetic PD wave propagates in the shield cable and the wave is attenuated while it travels. How significant the wave is is mainly determined by the HF loss properties of the cable, which has been discussed extensively in Section 2.2. Besides the losses of the cable, the cable splices and termination can also affect the wave propagation and attenuation. Figure 12 shows one typical PD wave propagation. The PD wave propagates in both directions passing through the cable splices before it reaches the cable termination and reflects back if the waves are not attenuated completely. When it travels along the cable, HF components are most attenuated due to the facts discussed in Section 2.2, because the displacement current increased with frequency resulting in higher losses for higher frequencies. This provides the electromagnetic wave pulse a big pulse width as shown in Figure 12. If the pulse is not attenuated completely, it will reach the cable termination and reflect backward toward the PD source as shown in Figure 12. To analyze the effect of the cable losses, the electromagnetic wave pulse can be treated as a Gaussian pulse. If a Gaussian pulse in time domain is applied at the left end of the cable to simulate the PD source signal, it will propagate through the splices before it can reach the termination. For simplicity, splices are thought in parallel with loads having characteristic impedance. Since we apply a Gaussian pulse in time domain, we need to transform it to the frequency domain, multiply it with attenuation factor caused by splices in frequency domain, then transform it back to time domain. The output voltage is attenuated by a factor of Vatt which is
where
where
One typical PD wave propagation pattern. Note that the wave propagates in both directions although only the right section is shown here.
Amplitude as a function of number of splice number. Splices have the following parameters: length, 60 cm; semicon conductivity, 5 s/m; conductor radius, 4 mm; thickness of the insulation, 4 mm; thickness of semicon, 6 mm; dielectric constant of semicon, 300; dielectric constant of insulation, 2.2.
Attenuated Gaussian pulse. The splice has the following parameters: radius of conductor, 1 cm; thickness of insulation, 0.5 cm; thickness of semicon, 0.3 cm; conductivity of semicon, 10 S/m; dielectric constant of semicon, 300; dielectric constant of insulation, 3.3; distance of splice, 40 cm.
The reader should keep in mind that the studied case is a simulation result based on some assumed shield dielectric properties. To assess the losses caused by the splices, some field measurements as well as further computations are necessary. Normally, the splices have smaller losses compared with the long cable.
PD detection has been extensively used for high-voltage apparatus diagnostic and status assessment. This section focuses on electromagnetic PD wave detection as, due to its relatively smaller losses, the HF PD signal can propagate for a long distance and can be detected by the PD sensors located either at the termination or other appropriate locations of the power circuit for the shielded power cables.
Different sensors (optical, acoustic, electrical, etc.) are used for detecting the PD. For detecting the electromagnetic waves propagating in shielded dielectric cables, normally a high-frequency current transformer (HFCT) and ultra high-frequency (UHF) sensor are used [18–21]. The HFCT is normally placed around the shielded cable or sometimes around the ground strip to collect the PD signals. The UHF sensor captures the UFH electromagnetic waves propagating in the shielded cable, which can be attenuated quickly depending on the loss characteristic of the cable. Figure 15 shows some typical configurations for using HFCT in the PD measurements. There are a lot of different other sensors such as coupling capacitor, inductively coupled probes, integrated partial discharge sensor, etc. that are used in PD electromagnetic pulse detections. Among them, the HFCTs are one of the most widely used sensors due to their high bandwidth and ease of use.
For processing the measured PD signals, different theories and algorithms have been proposed for optimizing PD testing results [18–21]. For partial discharge measurements, as stated in the above sections, the PD signals cannot be detected directly due to its nature as the PD is inside the insulation. The electromagnetic wave pulse signals we capture are indirect measurements of the PD and analysis needs to be done to extract useful information such as PD locations, PD magnitude, etc. Some PD detection technologies require an excitation voltage to produce a partial discharge signal pulse to find the PD location. For locating the PD location, two sensors are placed at two different locations along the cable and if the attenuation along the cable is the same, then when the two sensors reads the same level of PD, the PD source is in the middle of the two sensors assuming that the cable splices contribute little or few losses for the PD pulse propagation. Theoretically, the technology should work but an excitation voltage could damage the cable and the cable needs to be taken out of service. More and more PD detection systems have been developed for online real-time measurements as they don’t require dangerous excitation voltages and can be used to assess the HV apparatus under more realistic conditions. However, the highly noisy environment caused by the high voltage and high current of the power cable makes extracting useful PD information difficult. To improve the signal-to-noise ratio for optimized measurement results, different technologies, such as noise filtering, digital signal processing optimization, signal amplifying, etc., are used.
HFCT used in PD detection.
Some PD detection systems detect PD at the hot spots identified by the utility companies and can’t be used to monitor the system continuously due to the complicated data processing and communication. Due to the fact that the PD signals are normally HF signals which can attenuate quickly if a normal coaxial cable is used for connecting the PD detection sensor and the PD signal analyzer and also for safety concerns, sometimes, optical coupling [22] is used for long-distance data transmitting between the sensor and the PD data analyzer. After the field signals are received by data processors, which can be a wide-band oscilloscope or a spectrum analyzer, the PD data are processed for waveform, phase, span, etc. [28]. For better results, field signals can also be filtered and amplified and processed with specialized processing computers for trend analysis and alarm generation, etc.
With the advancement of modern wireless communication and digital signal processing technologies, real-time continuously online PD detection becomes more realistic [23-28]. Different wireless technologies have been used for transmitting measured processed data back to the controlling center. The processed output from the oscilloscope or other digital instruments can be fed into data transmitters using Ethernet, wireless LTE modem, Wifi, Zigbee network, etc. Ethernet is reliable and easy to use but sometimes it can be unavailable. Wireless LTE is flexible but can be expensive due to its common monthly data fee. Wifi is also a good option if it’s available. Zigbee is a low-cost and low-maintenance method compared with cellular data service as it does not have a monthly fee. The Zigbee node is small and, if set correctly, it can run for a long time without maintenance. Figure 16 shows one customized Zigbee node [29]. However, its data rate is relatively low compared with Ethernet and Wifi. To monitor the PD in real time, the captured PD signals can be processed with a wideband local oscilloscope or other devices such as a spectrum analyzer and the output can be fed into one of the data transmitting routers. The PD measurements will lead to a lot of raw data and normally they can’t be sent directly to the remote controlling center due to its high data volume. After processing, the data can be sent back to the controlling and data concentrator for appropriate actions such as cable maintenance, alarm generation, etc.
One Zigbee node.
Because the shielded power cables are widely used in modern HV power systems and the fact that the partial discharge is a powerful tool for assessing the HV power system status, HF PD electromagnetic wave propagation, detection, and analysis have been extensively studied. In this chapter, the authors look into the details of the shield power cable structure, their HF attenuation properties, PD electromagnetic wave propagation, and address the detection and analysis of the HF electromagnetic wave in the shielded power cable.
>restart;
>Rc:=4e-3:# Rc is the conductor radius.
>epsilon:=2.2:#Epsilon is the dielectric constant of the insulation.
>epsilon0:=8.85e-12:
>mu1:=1*4*Pi*1e-7:
>Rs:=11.7e-3: #Rs is the ground shield radius (m).
>Rd:=11.2E-3:#Rd is the insulation radius (m).
>V0:=1:
>N:=4:# N is the number of neutral wires.
>omega:=2*Pi*f:
>epsilon0:=8.85e-12:
>l:=1:# let the length of the cable be 1 m;
>T:=0.5e-3:# T is the thickness of the ground shield.
>T2:=0.2-3:# T2 is the thickness of the conductor shield.
>d:=evalf(2*Pi*Rs/N):# d is the length between two neutral wires.
>C:=2*Pi*epsilon*epsilon0*l/(ln(Rs/Rc)):# Capacitance of the insulation per meter.
>C1:=2*Pi*epsilon*epsilon0/(ln(Rd/Rc)):
>L1:=mu1*ln(Rs/Rc)/(2*Pi):
>Zc:=evalf(sqrt(L1/C1)):#Characteristic impedance.
>K1:=1/((sigma3+omega*epsilon0*epsilon3*I)*l*T):
>K2:=-2*I/omega/C/1*Pi*Rs+T2/(sigma4+omega*epsilon4*epsilon0*I)/1:
>I1:=
-V0*(exp(1/K2^(1/2)*K1^(1/2)*x)-exp(-K1^(1/2)*(-d+x)/K2^(1/2)))/K1^(1/
2)/K2^(1/2)/(1+exp(1/K2^(1/2)*K1^(1/2)*d)):#
Current distribution along the ground shield.
>V1:=-V0*(exp(1/K2^(1/2)*K1^(1/2)*x)+exp(-K1^(1/2)*(-d+x)/K2^(1/2)))/K2^(
1/2)/(1+exp(1/K2^(1/2)*K1^(1/2)*d)):#
90
Voltage distribution along the ground shield.
>I2:=(-V1)/K2:# Current flowing through the conductor shield.
>dZr4:=T2/(sigma4*l*dx):# dZr4 is the elemental resistive impedance of the
conductor shield.
>dZc4:=1/(I*omega*(epsilon0*epsilon4*l*dx/T2)):# dZc4 is the elemental capacitive
impedance of the conductor shield.
>Ratio2:=simplify(dZc4/(dZc4+dZr4)):# To get the current flowing through the
resistive component of the conductor shield, we calculate Ratio2.
>Irtotal2:=I2*Ratio2:# Irtotal2 is the current flowing through resistive component
of the conductor shield.
>dZr3:=(1*dx)/(sigma3*l*T):# Same as above.
>dZc3:=1/(I*omega*(epsilon0*epsilon3*l*T/dx)):# Same as above.
>Ratio1:=simplify(dZc3/(dZc3+dZr3)):# Same as above.
>Irtotal:=I1*Ratio1:# Irtotal1 is the current flowing through resistive component
of the ground shield.
>Ii:=Im(Irtotal):
>Ir:=Re(Irtotal):
>Ii2:=Im(Irtotal2):
>Ir2:=Re(Irtotal2):
>Pd4:=int(((Ir2)^2+(Ii2)^2)*(T2/(sigma4)),x=0..d/2):# Conductor shield power
dissipation
>Pd3:=int(((Ir)^2+(Ii)^2)*(1/(sigma3*T)),x=0..d/2):# Ground shield power dissipation
>Pin:=(V0)^2/Zc:# Input power.
>dB3:=10*log10(1-(Pd3*2*N/Pin)):# Ground shield attenuation.
>dB4:=10*log10(1-(Pd4*2*N/Pin)):# Conductor shield attenuation.
With the advent of constantly evolving and advancing ophthalmic imaging techniques as well as surgical modalities in the field of ophthalmic diseases, diagnostic accuracy, and treatment outcomes of ocular as well as orbital tumors have improved remarkably over the past few years. Raised intraocular pressure (IOP) is known to be one of the presenting features or associated finding for numerous ocular as well as orbital tumors. Ocular and orbital tumors can cause secondary glaucoma due to various mechanisms. They often pose a diagnostic challenge as well as a therapeutic dilemma owing to the complex pathophysiology involved. A thorough clinical evaluation, appropriate index of suspicion and optimum use of ancillary testing can lead to a proper diagnosis and management in such scenario.
Intraocular tumors that can lead to secondary glaucoma are malignancies like iris melanoma, iris metastasis, iris lymphoma, ciliochoroidal melanoma, retinoblastoma as well as benign pathologies like iris melanocytoma, benign ciliary body medulloepithelioma, diffuse choroidal hemangioma. [1] Indicators for a possible underlying intraocular tumor are, markedly elevated and often asymmetric level of IOP, acquired iris heterochromia, glaucoma non-responsive to optimum treatment or accompanying distinctive ocular features. [1, 2] The mechanism by which these tumors can cause secondary glaucoma varies with tumor type, size, and extent of the main tumor as well as seeding, tumor location, growth pattern, ongoing treatment along with secondary features related to the tumor. [3] Iris and predominantly ciliary body tumors located in anterior segment can cause glaucoma by direct infiltration of anterior chamber angle or because of iris neovascularization; while large tumors originating in retina or choroid are likely to cause glaucoma following iris neovascularization because of long standing or total retinal detachment or secondary angle closure. [1, 2]
Orbital tumors which can be congenital, traumatic, inflammatory, vascular, or neoplastic in origin may cause secondary glaucoma due to mass effect or anatomical and vascular changes leading to raised IOP [4] Orbital tumors causing raised orbital pressure may directly increase the IOP by increasing hydrostatic pressure around the globe or indirectly by raising the episcleral venous pressure.
Management of secondary glaucoma due to ocular and orbital tumors depends on both tumor characteristics and glaucoma related factors. Treatment of primary tumor may lead to IOP control in some cases while for others, management options include medical management, laser trabeculoplasty, transscleral cyclophotocoagulation, anti-VEGF injections, minimally invasive glaucoma surgery (MIGS), filtering or shunting surgery or enucleation. Glaucoma surgery like filtering or shunting procedure can be performed with due caution in proven benign or completely regressed tumors post-treatment. Such surgeries in an eye with suspected but unproven benign/malignant ocular tumor must be avoided to prevent unintended iatrogenic tumor dispersion or seeding especially in cases with iridociliary tumors or retinoblastoma.
Direct mechanism-
Solid tumor invasion- related outflow obstruction
Infiltrative tumor -related outflow obstruction
Trabecular meshwork seeding
Indirect mechanism-
Angle closure from neovascularization
Angle closure (compressive and rotational)
Ghost cell- Hemolytic
Elevated episcleral venous pressure
Anterior uveal tumors known to cause secondary glaucoma are iris/ciliary body melanocytoma, iris melanoma (nodular or diffuse), ciliary body melanoma (nodular or ring melanoma), iris lymphoma and iris metastasis. Direct invasion of the anterior chamber angle by infiltration followed by neovascularization and trabecular meshwork tumor seeding are the common etiologies of raised IOP in iris tumors; while pigment dispersion followed by direct angle invasion are the common etiologies for same in pigmented ciliary body tumors. [1, 2, 5, 6]
(A) Slit lamp image of iris melanocytoma; (B) Gonioscopy image of iris melanocytoma with extension of pigmentation up to the angle, (C) ultrasound biomicroscopy (UBM) image of iris melanocytoma appearing as irregular hyperreflective lesion on iris surface; (D) large iris melanocytoma leading to raised IOP due to angle closure glaucoma (compressive angle closure) {image credit for
Suspected melanocytoma can be observed cautiously. They are very rarely known to show malignant transformation. [9] Clear corneal approach fine needle aspiration biopsy, minimally invasive Finger Iridectomy technique (FIT), iridectomy or iridogoniocyclectomy can be utilized to obtain histopathological diagnosis in atypical iris nevi and suspected melanocytoma. [7, 10] Secondary glaucoma demonstrating melanocytoma eyes can be treated medically, by transscleral photocoagulation, by sector iridectomy or with glaucoma filtration surgery. [7, 8, 11, 12] However, a diagnostic confirmation of the lesion by prior biopsy and histopathology is mandated before planning a filtering surgery. Local surgical resection can be used to treat the secondary glaucoma caused by necrotic iris melanocytoma. [8, 13] Enucleation is reserved for painful blind eyes or eyes with absolute glaucoma.
(A) Slit lamp image of iris melanoma showing correctopia, ectropion uveae and extension up to the angle, (B) slit lamp image of diffuse iris melanoma presenting with angle closure, (C) slit lamp image of ciliary body melanoma with iris infiltration presenting as secondary glaucoma with hyphema. (D) Gonioscopy image of blood vessel (black arrowhead) at the anterior chamber angle in a case of diffuse iris melanoma with angle closure depicted in
Management of iris and iridociliary melanoma depends upon tumor size, location or extent, tumor seeding and presence of tumor related glaucoma. [15, 20] Local resection (iridectomy, iridocyclectomy), plaque brachytherapy, proton beam radiotherapy and enucleation are available treatment options for both nodular as well as diffuse iris melanoma. [6, 15, 20, 21] Secondary glaucoma in association with iris melanoma can be managed with medications, transscleral photocoagulation or laser trabeculoplasty. [22] Antivascular endothelial growth factor (anti-VEGF) injections can be tried in neovascular glaucoma. [23] Cases with refractory glaucoma resulting in blind painful eyes may warrant enucleation. [24] Filtering, shunting surgery or MIGS should be avoided in eyes with untreated tumor to prevent tumor spread outside of the globe. Diffuse iris melanoma or trabecular meshwork melanoma if misdiagnosed or missed prior to performing above named procedures can warrant enucleation for further tumor control. [3, 19]
(A) Slit lamp image of iris and ciliary body metastasis from lung adenocarcinoma showing correctopia, ectropion uveae, neovascularization of iris presenting with raised IOP (B) Ultrasound biomicroscopy image of iris metastasis with blunting of anterior chamber angle and thickened ciliary body (C) Slit lamp image of large choroidal melanoma presenting with intratumoral hemorrhage and raised IOP. (D) Ultrasound B scan of lesion in (C) showing low to moderately reflective choroidal melanoma with surrounding detached retina {image credit for
Other disorders like: Multiple myeloma, a malignant proliferation of plasma cells characterized by monoclonal production od immunoglobulins; Juvenile Xanthogranuloma, a benign histiocytic skin disorder can also affect anterior segment and lead to raised IOP. [2]
Contrary to traditional thinking, a recent study of analysis of glaucoma drainage device surgery for control of IOP in treated (totally regressed) uveal melanoma (both anterior as well as posterior) did not find a greater risk of local or extraocular recurrence after a median follow up of 2 years. [42] However, further analysis with larger sample size and longer follow up duration is warranted, and caution needs to be exercised while deciding regarding treatment options for control of IOP in such cases.
(A) Montage fundus image of choroidal metastasis from breast carcinoma presenting with multifocal lesions, retinal detachment and raised IOP. (B) Posterior pole fundus image of the same patient (A) showing radiation retinopathy after stereotactic radiotherapy (45Gy) (C) Fundus picture showing circumscribed choroidal hemangioma.
(A) Group E retinoblastoma presenting with total retinal detachment, iris neovascularization and neovascular glaucoma (clinical risk factors) (B) iris neovascularization (black arrowhead) (C) post chemotherapy tumor necrosis induced vitreous hemorrhage and secondary glaucoma in an eye with retinoblastoma (D) secondary glaucoma and sterile orbital inflammation in a case of retinoblastoma on systemic chemotherapy.
In instances where patient seeks attention with glaucoma as the presenting feature, a detailed work up involving slit lamp examination, dilated fundus examination, gonioscopy of anterior chamber angle, high frequency ultrasound microscopy (UBM) and ultrasound B scan of posterior segment will provide essential clues about diagnosis of possible intraocular tumor. Initial management with IOP lowering medications should be the first line treatment with simultaneous investigation for underlying cause. [2] When the tumor presents with atypical features or causes diagnostic uncertainty, a diagnostic biopsy is warranted in managing such case of secondary glaucoma. [55] Systemic work up with the help of positron emission tomography (PET) CT scan can come in handy while evaluating a case of possible secondary ocular metastasis by highlighting an existing primary malignancy elsewhere.
The orbit is a pyramidal structure limited by bony walls except from anteriorly where it is limited by soft tissue i.e., orbital septum and eyelids. Thus, any instances of increased orbital volume may lead to increased hydrostatic pressure in the orbit. This increased orbital pressure can have a direct effect of IOP by raised hydrostatic pressure around the eye or indirect effect by compression of episcleral and orbital veins raising venous pressure. The episcleral venous system mainly empties into the anterior ciliary and superior ophthalmic veins and eventually draining into cavernous sinus. Thus, any disease process that might affect this drainage pathway due to structural, occlusive, compressive, or destructive pathophysiology can alter and raise IOP causing secondary glaucoma. [4] Focal mass effect due to tumors or swollen extraocular muscles may directly compress the eye globe leading to raised IOP while, vascular changes affecting venous pressure due to compression of episcleral veins or altered arterio-venous flow may also increase IOP indirectly.
Table 1 summarizes the broad etiological classes of orbital tumors leading to rise in IOP and secondary glaucoma. Open angle glaucoma is more common in the listed diseases however, angle closure along with acute angle closure glaucoma has also been reported in variety of pathologies.
Sr. No | Etiology | Example |
---|---|---|
1 | Inflammatory | Non-specific Orbital Inflammatory Disease (NSOID) Thyroid eye disease Orbital granulomatous disease Orbital Foreign Body granuloma Juvenile Xanthogranuloma (orbital histiocytosis) |
2 | Vascular | Carotid-cavernous fistula (Direct or Indirect) Arterio-venous malformations Orbital varix Cavernous hemangioma Orbital lymphangioma |
3 | Neoplastic | Orbital osteoma Lymphoproliferative disorders Optic nerve glioma Optic nerve meningioma Neurofibromatosis Lacrimal gland tumors Primary orbital melanoma |
4 | Secondary | Orbital metastasis (from breast, lung carcinoma) Orbital chloroma (Acute myeloid leukemia) Multiple myeloma Invasive (secondary) ocular melanoma Extra-scleral (orbital) extension of retinoblastoma Invasive (secondary) squamous cell carcinoma |
5 | Miscellaneous | Orbital amyloidosis Mucopolysaccharidoses Phakomatosis (Neurocutaneous syndromes) Collagen tissue disorders (Lupus erythematosus, Wegener granulomatosis) |
Etiologic classification of orbital tumors causing secondary glaucoma.
IOP evaluation should be routinely performed when evaluating a case of suspected orbital tumor or pathology. Gonioscopic examination can provide essential information regarding the status of the anterior chamber angle as well as show evidence of blood in Schlemm’s canal as the distinguishing feature of elevated venous pressure. The treatment of primary orbital pathology along with medical management of raised IOP is indicated for control of orbital tumor related secondary glaucoma.
In sum, glaucoma can be associated with various ocular as well as orbital tumors. It may constitute one of the many manifesting clinical features or be the sole presenting feature of these pathologies. Appropriate diagnosis and timely management of these tumors can help eye and vision salvage; however, a misdiagnosis or delayed diagnosis due to initial presentation as secondary glaucoma can lead to catastrophic sequel necessitating enucleation and can pose a greater risk to life. A thorough clinical evaluation, use of ancillary testing and stepwise management can help achieve optimum visual outcome and overall survival in cases with ocular or orbital tumors.
The author acknowledges contributions from Dr. Paul T Finger MD, FACS, Director- The New York Eye Cancer Center, New York, USA and Dr. Santosh G Honavar MD, FACS, Director- Ocular Oncology Services, Centre For Sight Hospital, Hyderabad, India for select clinical images used in this chapter.
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These reactions occur through a regular radical chain causing growth of polymer by three steps, namely, initiation, propagation, and termination. To understand ionizing radiation-induced polymerization, the water radiolysis must be taken into consideration. This chapter explores the mechanism of water molecules radiolysis paying especial attention to the basic regularities of solvent radicals’ interaction with the polymer molecules for forming the crosslinked polymer. Water radiolysis is the main engine of the polymerization processes, especially the “free-radical polymerization.” The mechanisms of the free-radical polymerization and crosslinking will be discussed in detail later. Since different polymers respond differently to radiation, it is useful to quantify the response, namely in terms of crosslinking and chain scission. A parameter called the G-value is frequently used for this purpose. It represents the chemical yield of crosslinks, scissions and double bonds, etc. For the crosslinked polymer, the crosslinking density increases with increasing the radiation dose, this is reflected by the swelling degree of the polymer while being immersed in a compatible solvent. If crosslinking predominates, the crosslinking density increases and the extent of swelling decreases. If chain scission predominates, the opposite occurs. 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The natural resources are limited, and due to the natural disasters like sudden and severe abiotic stress factors, excessive floods, etc., the production capacities are changed per year. In contrast, the yield potential should be significantly increased to cope with this problem. Despite rich genetic diversity, manipulation of the cultivars through alternative techniques such as mutation breeding becomes important. Radiation is proven as an effective method as a unique method to increase the genetic variability of the species. Gamma radiation is the most preferred physical mutagen by plant breeders. Several mutant varieties have been successfully introduced into commercial production by this method. Combinational use of in vitro tissue culture and mutation breeding methods makes a significant contribution to improve new crops. Large populations and the target mutations can be easily screened and identified by new methods. Marker assisted selection and advanced techniques such as microarray, next generation sequencing methods to detect a specific mutant in a large population will help to the plant breeders to use ionizing radiation efficiently in breeding programs.",book:{id:"5451",slug:"new-insights-on-gamma-rays",title:"New Insights on Gamma Rays",fullTitle:"New Insights on Gamma Rays"},signatures:"Özge Çelik and Çimen Atak",authors:[{id:"147362",title:"Dr.",name:"Özge",middleName:null,surname:"Çelik",slug:"ozge-celik",fullName:"Özge Çelik"},{id:"147364",title:"Prof.",name:"Çimen",middleName:null,surname:"Atak",slug:"cimen-atak",fullName:"Çimen Atak"}]},{id:"32846",doi:"10.5772/36950",title:"Current Importance and Potential Use of Low Doses of Gamma Radiation in Forest Species",slug:"current-importance-and-potential-use-of-low-doses-of-gamma-radiation-in-forest-species",totalDownloads:5277,totalCrossrefCites:2,totalDimensionsCites:13,abstract:null,book:{id:"1590",slug:"gamma-radiation",title:"Gamma Radiation",fullTitle:"Gamma Radiation"},signatures:"L. 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In this chapter, the following aspects of radiation treatment process are considered: sources of contamination and major contaminants of water and wastewater; primary processes in aqueous systems initiated by ionizing radiation; principal ways of contaminant conversion as consequences of primary processes (complete mineralization of organic compounds, partial decomposition of organic molecules resulted in detoxification, decolorization, disinfection of polluted water, and improvement in biological degradation of contaminant, polymerization of monomers’ contaminants, oxidation-reduction processes, and coagulation of colloids); sources of ionizing radiation; and main equipment applied in radiation technologies of aqueous system purification.",book:{id:"6149",slug:"ionizing-radiation-effects-and-applications",title:"Ionizing Radiation Effects and Applications",fullTitle:"Ionizing Radiation Effects and Applications"},signatures:"Igor E. Makarov and Alexander V. Ponomarev",authors:[{id:"213652",title:"Dr.",name:"Igor",middleName:null,surname:"Makarov",slug:"igor-makarov",fullName:"Igor Makarov"},{id:"213657",title:"Dr.",name:"Alexander",middleName:null,surname:"Ponomarev",slug:"alexander-ponomarev",fullName:"Alexander Ponomarev"}]}],mostDownloadedChaptersLast30Days:[{id:"32842",title:"Sterilization by Gamma Irradiation",slug:"sterilization-by-gamma-irradiation",totalDownloads:74766,totalCrossrefCites:37,totalDimensionsCites:85,abstract:null,book:{id:"1590",slug:"gamma-radiation",title:"Gamma Radiation",fullTitle:"Gamma Radiation"},signatures:"Kátia Aparecida da Silva Aquino",authors:[{id:"102109",title:"Dr.",name:"Katia",middleName:"Aparecida Da S.",surname:"Aquino",slug:"katia-aquino",fullName:"Katia Aquino"}]},{id:"32837",title:"Environmental Gamma-Ray Observation in Deep Sea",slug:"environmental-gamma-ray-observation-in-deep-sea-",totalDownloads:2917,totalCrossrefCites:4,totalDimensionsCites:6,abstract:null,book:{id:"1590",slug:"gamma-radiation",title:"Gamma Radiation",fullTitle:"Gamma Radiation"},signatures:"Hidenori Kumagai, Ryoichi Iwase, Masataka Kinoshita, Hideaki Machiyama, Mutsuo Hattori and Masaharu Okano",authors:[{id:"108174",title:"Dr.",name:"Hidenori",middleName:null,surname:"Kumagai",slug:"hidenori-kumagai",fullName:"Hidenori Kumagai"},{id:"108237",title:"Dr.",name:"Masa",middleName:null,surname:"Kinoshita",slug:"masa-kinoshita",fullName:"Masa Kinoshita"},{id:"137650",title:"Dr.",name:"Ryoichi",middleName:null,surname:"Iwase",slug:"ryoichi-iwase",fullName:"Ryoichi Iwase"},{id:"137656",title:"Dr.",name:"Hideaki",middleName:null,surname:"Machiyama",slug:"hideaki-machiyama",fullName:"Hideaki Machiyama"},{id:"146918",title:"Dr.",name:"Mutsuo",middleName:null,surname:"Hattori",slug:"mutsuo-hattori",fullName:"Mutsuo Hattori"},{id:"146919",title:"Dr.",name:"Masaharu",middleName:null,surname:"Okano",slug:"masaharu-okano",fullName:"Masaharu Okano"}]},{id:"58998",title:"Ionizing Radiation-Induced Polymerization",slug:"ionizing-radiation-induced-polymerization",totalDownloads:1784,totalCrossrefCites:8,totalDimensionsCites:17,abstract:"Ionizing radiation can induce some kinds of reactions, other than polymerization, such as dimerization, oligomerization, curing, and grafting. These reactions occur through a regular radical chain causing growth of polymer by three steps, namely, initiation, propagation, and termination. To understand ionizing radiation-induced polymerization, the water radiolysis must be taken into consideration. This chapter explores the mechanism of water molecules radiolysis paying especial attention to the basic regularities of solvent radicals’ interaction with the polymer molecules for forming the crosslinked polymer. Water radiolysis is the main engine of the polymerization processes, especially the “free-radical polymerization.” The mechanisms of the free-radical polymerization and crosslinking will be discussed in detail later. Since different polymers respond differently to radiation, it is useful to quantify the response, namely in terms of crosslinking and chain scission. A parameter called the G-value is frequently used for this purpose. It represents the chemical yield of crosslinks, scissions and double bonds, etc. For the crosslinked polymer, the crosslinking density increases with increasing the radiation dose, this is reflected by the swelling degree of the polymer while being immersed in a compatible solvent. If crosslinking predominates, the crosslinking density increases and the extent of swelling decreases. If chain scission predominates, the opposite occurs. A further detailed discussion of these aspects is presented throughout this chapter.",book:{id:"6149",slug:"ionizing-radiation-effects-and-applications",title:"Ionizing Radiation Effects and Applications",fullTitle:"Ionizing Radiation Effects and Applications"},signatures:"Mohamed Mohamady Ghobashy",authors:[{id:"212371",title:"Dr.",name:"Mohamed",middleName:null,surname:"Mohamady Ghobashy",slug:"mohamed-mohamady-ghobashy",fullName:"Mohamed Mohamady Ghobashy"}]},{id:"53780",title:"Gamma-Ray Spectrometry and the Investigation of Environmental and Food Samples",slug:"gamma-ray-spectrometry-and-the-investigation-of-environmental-and-food-samples",totalDownloads:2501,totalCrossrefCites:1,totalDimensionsCites:1,abstract:"Gamma radiation consists of high‐energy photons and penetrates matter. This is an advantage for the detection of gamma rays, as gamma spectrometry does not need the elimination of the matrix. The disadvantage is the need of shielding to protect against this radiation. Gamma rays are everywhere: in the atmosphere; gamma nuclides are produced by radiation of the sun; in the Earth, the primordial radioactive nuclides thorium and uranium are sources for gamma and other radiation. The technical enrichment and use of radioisotopes led to the unscrupulously use of radioactive material and to the Cold War, with over 900 bomb tests from 1945 to 1990, combined with global fallout over the northern hemisphere. The friendly use of radiation in medicine and for the production of energy at nuclear power plants (NPPs) has caused further expositions with ionising radiation. This chapter describes in a practical manner the instrumentation for the detection of gamma radiation and some results of the use of these techniques in environmental and food investigations.",book:{id:"5451",slug:"new-insights-on-gamma-rays",title:"New Insights on Gamma Rays",fullTitle:"New Insights on Gamma Rays"},signatures:"Markus R. Zehringer",authors:[{id:"311750",title:"Dr.",name:"Markus R.",middleName:null,surname:"Zehringer",slug:"markus-r.-zehringer",fullName:"Markus R. Zehringer"}]},{id:"54118",title:"Gamma Rays from Space",slug:"gamma-rays-from-space",totalDownloads:2052,totalCrossrefCites:1,totalDimensionsCites:1,abstract:"An overview of gamma rays from space is presented. We highlight the most powerful astrophysical explosions, known as gamma-ray bursts. The main features observed in detectors onboard satellites are indicated. In addition, we also highlight a chronological description of the efforts made to observe their high energy counterpart at ground level. Some candidates of the GeV counterpart of gamma-ray bursts, observed by Tupi telescopes, are also presented.",book:{id:"5451",slug:"new-insights-on-gamma-rays",title:"New Insights on Gamma Rays",fullTitle:"New Insights on Gamma Rays"},signatures:"Carlos Navia and Marcel Nogueira de Oliveira",authors:[{id:"189908",title:"Dr.",name:"Carlos",middleName:null,surname:"Navia",slug:"carlos-navia",fullName:"Carlos Navia"},{id:"243084",title:"MSc.",name:"Marcel",middleName:null,surname:"De Oliveira",slug:"marcel-de-oliveira",fullName:"Marcel De Oliveira"}]}],onlineFirstChaptersFilter:{topicId:"227",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:0,limit:8,total:null},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:89,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:32,numberOfPublishedChapters:318,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:106,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:5,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:15,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"14",title:"Artificial Intelligence",doi:"10.5772/intechopen.79920",issn:"2633-1403",scope:"Artificial Intelligence (AI) is a rapidly developing multidisciplinary research area that aims to solve increasingly complex problems. In today's highly integrated world, AI promises to become a robust and powerful means for obtaining solutions to previously unsolvable problems. This Series is intended for researchers and students alike interested in this fascinating field and its many applications.",coverUrl:"https://cdn.intechopen.com/series/covers/14.jpg",latestPublicationDate:"June 11th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:9,editor:{id:"218714",title:"Prof.",name:"Andries",middleName:null,surname:"Engelbrecht",slug:"andries-engelbrecht",fullName:"Andries Engelbrecht",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRNR8QAO/Profile_Picture_1622640468300",biography:"Andries Engelbrecht received the Masters and PhD degrees in Computer Science from the University of Stellenbosch, South Africa, in 1994 and 1999 respectively. He is currently appointed as the Voigt Chair in Data Science in the Department of Industrial Engineering, with a joint appointment as Professor in the Computer Science Division, Stellenbosch University. Prior to his appointment at Stellenbosch University, he has been at the University of Pretoria, Department of Computer Science (1998-2018), where he was appointed as South Africa Research Chair in Artifical Intelligence (2007-2018), the head of the Department of Computer Science (2008-2017), and Director of the Institute for Big Data and Data Science (2017-2018). In addition to a number of research articles, he has written two books, Computational Intelligence: An Introduction and Fundamentals of Computational Swarm Intelligence.",institutionString:null,institution:{name:"Stellenbosch University",institutionURL:null,country:{name:"South Africa"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:6,paginationItems:[{id:"22",title:"Applied Intelligence",coverUrl:"https://cdn.intechopen.com/series_topics/covers/22.jpg",isOpenForSubmission:!0,editor:{id:"27170",title:"Prof.",name:"Carlos",middleName:"M.",surname:"Travieso-Gonzalez",slug:"carlos-travieso-gonzalez",fullName:"Carlos Travieso-Gonzalez",profilePictureURL:"https://mts.intechopen.com/storage/users/27170/images/system/27170.jpeg",biography:"Carlos M. Travieso-González received his MSc degree in Telecommunication Engineering at Polytechnic University of Catalonia (UPC), Spain in 1997, and his Ph.D. degree in 2002 at the University of Las Palmas de Gran Canaria (ULPGC-Spain). He is a full professor of signal processing and pattern recognition and is head of the Signals and Communications Department at ULPGC, teaching from 2001 on subjects on signal processing and learning theory. His research lines are biometrics, biomedical signals and images, data mining, classification system, signal and image processing, machine learning, and environmental intelligence. He has researched in 52 international and Spanish research projects, some of them as head researcher. He is co-author of 4 books, co-editor of 27 proceedings books, guest editor for 8 JCR-ISI international journals, and up to 24 book chapters. He has over 450 papers published in international journals and conferences (81 of them indexed on JCR – ISI - Web of Science). He has published seven patents in the Spanish Patent and Trademark Office. He has been a supervisor on 8 Ph.D. theses (11 more are under supervision), and 130 master theses. He is the founder of The IEEE IWOBI conference series and the president of its Steering Committee, as well as the founder of both the InnoEducaTIC and APPIS conference series. He is an evaluator of project proposals for the European Union (H2020), Medical Research Council (MRC, UK), Spanish Government (ANECA, Spain), Research National Agency (ANR, France), DAAD (Germany), Argentinian Government, and the Colombian Institutions. He has been a reviewer in different indexed international journals (<70) and conferences (<250) since 2001. He has been a member of the IASTED Technical Committee on Image Processing from 2007 and a member of the IASTED Technical Committee on Artificial Intelligence and Expert Systems from 2011. \n\nHe has held the general chair position for the following: ACM-APPIS (2020, 2021), IEEE-IWOBI (2019, 2020 and 2020), A PPIS (2018, 2019), IEEE-IWOBI (2014, 2015, 2017, 2018), InnoEducaTIC (2014, 2017), IEEE-INES (2013), NoLISP (2011), JRBP (2012), and IEEE-ICCST (2005)\n\nHe is an associate editor of the Computational Intelligence and Neuroscience Journal (Hindawi – Q2 JCR-ISI). He was vice dean from 2004 to 2010 in the Higher Technical School of Telecommunication Engineers at ULPGC and the vice dean of Graduate and Postgraduate Studies from March 2013 to November 2017. He won the “Catedra Telefonica” Awards in Modality of Knowledge Transfer, 2017, 2018, and 2019 editions, and awards in Modality of COVID Research in 2020.\n\nPublic References:\nResearcher ID http://www.researcherid.com/rid/N-5967-2014\nORCID https://orcid.org/0000-0002-4621-2768 \nScopus Author ID https://www.scopus.com/authid/detail.uri?authorId=6602376272\nScholar Google https://scholar.google.es/citations?user=G1ks9nIAAAAJ&hl=en \nResearchGate https://www.researchgate.net/profile/Carlos_Travieso",institutionString:null,institution:{name:"University of Las Palmas de Gran Canaria",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"23",title:"Computational Neuroscience",coverUrl:"https://cdn.intechopen.com/series_topics/covers/23.jpg",isOpenForSubmission:!0,editor:{id:"14004",title:"Dr.",name:"Magnus",middleName:null,surname:"Johnsson",slug:"magnus-johnsson",fullName:"Magnus Johnsson",profilePictureURL:"https://mts.intechopen.com/storage/users/14004/images/system/14004.png",biography:"Dr Magnus Johnsson is a cross-disciplinary scientist, lecturer, scientific editor and AI/machine learning consultant from Sweden. \n\nHe is currently at Malmö University in Sweden, but also held positions at Lund University in Sweden and at Moscow Engineering Physics Institute. \nHe holds editorial positions at several international scientific journals and has served as a scientific editor for books and special journal issues. \nHis research interests are wide and include, but are not limited to, autonomous systems, computer modeling, artificial neural networks, artificial intelligence, cognitive neuroscience, cognitive robotics, cognitive architectures, cognitive aids and the philosophy of mind. \n\nDr. Johnsson has experience from working in the industry and he has a keen interest in the application of neural networks and artificial intelligence to fields like industry, finance, and medicine. \n\nWeb page: www.magnusjohnsson.se",institutionString:null,institution:{name:"Malmö University",institutionURL:null,country:{name:"Sweden"}}},editorTwo:null,editorThree:null},{id:"24",title:"Computer Vision",coverUrl:"https://cdn.intechopen.com/series_topics/covers/24.jpg",isOpenForSubmission:!0,editor:{id:"294154",title:"Prof.",name:"George",middleName:null,surname:"Papakostas",slug:"george-papakostas",fullName:"George Papakostas",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002hYaGbQAK/Profile_Picture_1624519712088",biography:"George A. Papakostas has received a diploma in Electrical and Computer Engineering in 1999 and the M.Sc. and Ph.D. degrees in Electrical and Computer Engineering in 2002 and 2007, respectively, from the Democritus University of Thrace (DUTH), Greece. Dr. Papakostas serves as a Tenured Full Professor at the Department of Computer Science, International Hellenic University, Greece. Dr. Papakostas has 10 years of experience in large-scale systems design as a senior software engineer and technical manager, and 20 years of research experience in the field of Artificial Intelligence. Currently, he is the Head of the “Visual Computing” division of HUman-MAchines INteraction Laboratory (HUMAIN-Lab) and the Director of the MPhil program “Advanced Technologies in Informatics and Computers” hosted by the Department of Computer Science, International Hellenic University. He has (co)authored more than 150 publications in indexed journals, international conferences and book chapters, 1 book (in Greek), 3 edited books, and 5 journal special issues. His publications have more than 2100 citations with h-index 27 (GoogleScholar). His research interests include computer/machine vision, machine learning, pattern recognition, computational intelligence. \nDr. Papakostas served as a reviewer in numerous journals, as a program\ncommittee member in international conferences and he is a member of the IAENG, MIR Labs, EUCogIII, INSTICC and the Technical Chamber of Greece (TEE).",institutionString:null,institution:{name:"International Hellenic University",institutionURL:null,country:{name:"Greece"}}},editorTwo:null,editorThree:null},{id:"25",title:"Evolutionary Computation",coverUrl:"https://cdn.intechopen.com/series_topics/covers/25.jpg",isOpenForSubmission:!0,editor:{id:"136112",title:"Dr.",name:"Sebastian",middleName:null,surname:"Ventura Soto",slug:"sebastian-ventura-soto",fullName:"Sebastian Ventura Soto",profilePictureURL:"https://mts.intechopen.com/storage/users/136112/images/system/136112.png",biography:"Sebastian Ventura is a Spanish researcher, a full professor with the Department of Computer Science and Numerical Analysis, University of Córdoba. Dr Ventura also holds the positions of Affiliated Professor at Virginia Commonwealth University (Richmond, USA) and Distinguished Adjunct Professor at King Abdulaziz University (Jeddah, Saudi Arabia). Additionally, he is deputy director of the Andalusian Research Institute in Data Science and Computational Intelligence (DaSCI) and heads the Knowledge Discovery and Intelligent Systems Research Laboratory. He has published more than ten books and over 300 articles in journals and scientific conferences. Currently, his work has received over 18,000 citations according to Google Scholar, including more than 2200 citations in 2020. In the last five years, he has published more than 60 papers in international journals indexed in the JCR (around 70% of them belonging to first quartile journals) and he has edited some Springer books “Supervised Descriptive Pattern Mining” (2018), “Multiple Instance Learning - Foundations and Algorithms” (2016), and “Pattern Mining with Evolutionary Algorithms” (2016). He has also been involved in more than 20 research projects supported by the Spanish and Andalusian governments and the European Union. He currently belongs to the editorial board of PeerJ Computer Science, Information Fusion and Engineering Applications of Artificial Intelligence journals, being also associate editor of Applied Computational Intelligence and Soft Computing and IEEE Transactions on Cybernetics. Finally, he is editor-in-chief of Progress in Artificial Intelligence. He is a Senior Member of the IEEE Computer, the IEEE Computational Intelligence, and the IEEE Systems, Man, and Cybernetics Societies, and the Association of Computing Machinery (ACM). Finally, his main research interests include data science, computational intelligence, and their applications.",institutionString:null,institution:{name:"University of Córdoba",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"26",title:"Machine Learning and Data Mining",coverUrl:"https://cdn.intechopen.com/series_topics/covers/26.jpg",isOpenForSubmission:!0,editor:{id:"24555",title:"Dr.",name:"Marco Antonio",middleName:null,surname:"Aceves Fernandez",slug:"marco-antonio-aceves-fernandez",fullName:"Marco Antonio Aceves Fernandez",profilePictureURL:"https://mts.intechopen.com/storage/users/24555/images/system/24555.jpg",biography:"Dr. Marco Antonio Aceves Fernandez obtained his B.Sc. (Eng.) in Telematics from the Universidad de Colima, Mexico. He obtained both his M.Sc. and Ph.D. from the University of Liverpool, England, in the field of Intelligent Systems. He is a full professor at the Universidad Autonoma de Queretaro, Mexico, and a member of the National System of Researchers (SNI) since 2009. Dr. Aceves Fernandez has published more than 80 research papers as well as a number of book chapters and congress papers. He has contributed in more than 20 funded research projects, both academic and industrial, in the area of artificial intelligence, ranging from environmental, biomedical, automotive, aviation, consumer, and robotics to other applications. He is also a honorary president at the National Association of Embedded Systems (AMESE), a senior member of the IEEE, and a board member of many institutions. His research interests include intelligent and embedded systems.",institutionString:"Universidad Autonoma de Queretaro",institution:{name:"Autonomous University of Queretaro",institutionURL:null,country:{name:"Mexico"}}},editorTwo:null,editorThree:null},{id:"27",title:"Multi-Agent Systems",coverUrl:"https://cdn.intechopen.com/series_topics/covers/27.jpg",isOpenForSubmission:!0,editor:{id:"148497",title:"Dr.",name:"Mehmet",middleName:"Emin",surname:"Aydin",slug:"mehmet-aydin",fullName:"Mehmet Aydin",profilePictureURL:"https://mts.intechopen.com/storage/users/148497/images/system/148497.jpg",biography:"Dr. Mehmet Emin Aydin is a Senior Lecturer with the Department of Computer Science and Creative Technology, the University of the West of England, Bristol, UK. His research interests include swarm intelligence, parallel and distributed metaheuristics, machine learning, intelligent agents and multi-agent systems, resource planning, scheduling and optimization, combinatorial optimization. Dr. Aydin is currently a Fellow of Higher Education Academy, UK, a member of EPSRC College, a senior member of IEEE and a senior member of ACM. In addition to being a member of advisory committees of many international conferences, he is an Editorial Board Member of various peer-reviewed international journals. 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Singh",profilePictureURL:"https://mts.intechopen.com/storage/users/329385/images/system/329385.png",institutionString:"Punjab Technical University",institution:{name:"Punjab Technical University",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"8018",title:"Extracellular Matrix",subtitle:"Developments and Therapeutics",coverURL:"https://cdn.intechopen.com/books/images_new/8018.jpg",slug:"extracellular-matrix-developments-and-therapeutics",publishedDate:"October 27th 2021",editedByType:"Edited by",bookSignature:"Rama Sashank Madhurapantula, Joseph Orgel P.R.O. and Zvi Loewy",hash:"c85e82851e80b40282ff9be99ddf2046",volumeInSeries:23,fullTitle:"Extracellular Matrix - Developments and Therapeutics",editors:[{id:"212416",title:"Dr.",name:"Rama Sashank",middleName:null,surname:"Madhurapantula",slug:"rama-sashank-madhurapantula",fullName:"Rama Sashank Madhurapantula",profilePictureURL:"https://mts.intechopen.com/storage/users/212416/images/system/212416.jpg",institutionString:"Illinois Institute of Technology",institution:{name:"Illinois Institute of Technology",institutionURL:null,country:{name:"United States of America"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9759",title:"Vitamin E in Health and Disease",subtitle:"Interactions, Diseases and Health Aspects",coverURL:"https://cdn.intechopen.com/books/images_new/9759.jpg",slug:"vitamin-e-in-health-and-disease-interactions-diseases-and-health-aspects",publishedDate:"October 6th 2021",editedByType:"Edited by",bookSignature:"Pınar Erkekoglu and Júlia Scherer Santos",hash:"6c3ddcc13626110de289b57f2516ac8f",volumeInSeries:22,fullTitle:"Vitamin E in Health and Disease - Interactions, Diseases and Health Aspects",editors:[{id:"109978",title:"Prof.",name:"Pınar",middleName:null,surname:"Erkekoğlu",slug:"pinar-erkekoglu",fullName:"Pınar Erkekoğlu",profilePictureURL:"https://mts.intechopen.com/storage/users/109978/images/system/109978.jpg",institutionString:"Hacettepe University",institution:{name:"Hacettepe University",institutionURL:null,country:{name:"Turkey"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Proteomics",value:18,count:4},{group:"subseries",caption:"Metabolism",value:17,count:6},{group:"subseries",caption:"Cell and Molecular Biology",value:14,count:9},{group:"subseries",caption:"Chemical Biology",value:15,count:13}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:8},{group:"publicationYear",caption:"2021",value:2021,count:7},{group:"publicationYear",caption:"2020",value:2020,count:12},{group:"publicationYear",caption:"2019",value:2019,count:3},{group:"publicationYear",caption:"2018",value:2018,count:2}],authors:{paginationCount:229,paginationItems:[{id:"318170",title:"Dr.",name:"Aneesa",middleName:null,surname:"Moolla",slug:"aneesa-moolla",fullName:"Aneesa Moolla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/318170/images/system/318170.png",biography:"Dr. Aneesa Moolla has extensive experience in the diverse fields of health care having previously worked in dental private practice, at the Red Cross Flying Doctors association, and in healthcare corporate settings. She is now a lecturer at the University of Witwatersrand, South Africa, and a principal researcher at the Health Economics and Epidemiology Research Office (HE2RO), South Africa. Dr. Moolla holds a Ph.D. in Psychology with her research being focused on mental health and resilience. In her professional work capacity, her research has further expanded into the fields of early childhood development, mental health, the HIV and TB care cascades, as well as COVID. She is also a UNESCO-trained International Bioethics Facilitator.",institutionString:"University of the Witwatersrand",institution:{name:"University of the Witwatersrand",country:{name:"South Africa"}}},{id:"419588",title:"Ph.D.",name:"Sergio",middleName:"Alexandre",surname:"Gehrke",slug:"sergio-gehrke",fullName:"Sergio Gehrke",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038WgMKQA0/Profile_Picture_2022-06-02T11:44:20.jpg",biography:"Dr. Sergio Alexandre Gehrke is a doctorate holder in two fields. The first is a Ph.D. in Cellular and Molecular Biology from the Pontificia Catholic University, Porto Alegre, Brazil, in 2010 and the other is an International Ph.D. in Bioengineering from the Universidad Miguel Hernandez, Elche/Alicante, Spain, obtained in 2020. In 2018, he completed a postdoctoral fellowship in Materials Engineering in the NUCLEMAT of the Pontificia Catholic University, Porto Alegre, Brazil. He is currently the Director of the Postgraduate Program in Implantology of the Bioface/UCAM/PgO (Montevideo, Uruguay), Director of the Cathedra of Biotechnology of the Catholic University of Murcia (Murcia, Spain), an Extraordinary Full Professor of the Catholic University of Murcia (Murcia, Spain) as well as the Director of the private center of research Biotecnos – Technology and Science (Montevideo, Uruguay). Applied biomaterials, cellular and molecular biology, and dental implants are among his research interests. He has published several original papers in renowned journals. In addition, he is also a Collaborating Professor in several Postgraduate programs at different universities all over the world.",institutionString:null,institution:{name:"Universidad Católica San Antonio de Murcia",country:{name:"Spain"}}},{id:"342152",title:"Dr.",name:"Santo",middleName:null,surname:"Grace Umesh",slug:"santo-grace-umesh",fullName:"Santo Grace Umesh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/342152/images/16311_n.jpg",biography:null,institutionString:null,institution:{name:"SRM Dental College",country:{name:"India"}}},{id:"333647",title:"Dr.",name:"Shreya",middleName:null,surname:"Kishore",slug:"shreya-kishore",fullName:"Shreya Kishore",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/333647/images/14701_n.jpg",biography:"Dr. Shreya Kishore completed her Bachelor in Dental Surgery in Chettinad Dental College and Research Institute, Chennai, and her Master of Dental Surgery (Orthodontics) in Saveetha Dental College, Chennai. She is also Invisalign certified. She’s working as a Senior Lecturer in the Department of Orthodontics, SRM Dental College since November 2019. She is actively involved in teaching orthodontics to the undergraduates and the postgraduates. Her clinical research topics include new orthodontic brackets, fixed appliances and TADs. She’s published 4 articles in well renowned indexed journals and has a published patency of her own. Her private practice is currently limited to orthodontics and works as a consultant in various clinics.",institutionString:null,institution:{name:"SRM Dental College",country:{name:"India"}}},{id:"323731",title:"Prof.",name:"Deepak M.",middleName:"Macchindra",surname:"Vikhe",slug:"deepak-m.-vikhe",fullName:"Deepak M. Vikhe",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/323731/images/13613_n.jpg",biography:"Dr Deepak M.Vikhe .\n\n\t\n\tDr Deepak M.Vikhe , completed his Masters & PhD in Prosthodontics from Rural Dental College, Loni securing third rank in the Pravara Institute of Medical Sciences Deemed University. He was awarded Dr.G.C.DAS Memorial Award for Research on Implants at 39th IPS conference Dubai (U A E).He has two patents under his name. He has received Dr.Saraswati medal award for best research for implant study in 2017.He has received Fully funded scholarship to Spain ,university of Santiago de Compostela. He has completed fellowship in Implantlogy from Noble Biocare. \nHe has attended various conferences and CDE programmes and has national publications to his credit. His field of interest is in Implant supported prosthesis. Presently he is working as a associate professor in the Dept of Prosthodontics, Rural Dental College, Loni and maintains a successful private practice specialising in Implantology at Rahata.\n\nEmail: drdeepak_mvikhe@yahoo.com..................",institutionString:null,institution:{name:"Pravara Institute of Medical Sciences",country:{name:"India"}}},{id:"204110",title:"Dr.",name:"Ahmed A.",middleName:null,surname:"Madfa",slug:"ahmed-a.-madfa",fullName:"Ahmed A. Madfa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204110/images/system/204110.jpg",biography:"Dr. Madfa is currently Associate Professor of Endodontics at Thamar University and a visiting lecturer at Sana'a University and University of Sciences and Technology. He has more than 6 years of experience in teaching. His research interests include root canal morphology, functionally graded concept, dental biomaterials, epidemiology and dental education, biomimetic restoration, finite element analysis and endodontic regeneration. Dr. Madfa has numerous international publications, full articles, two patents, a book and a book chapter. Furthermore, he won 14 international scientific awards. Furthermore, he is involved in many academic activities ranging from editorial board member, reviewer for many international journals and postgraduate students' supervisor. Besides, I deliver many courses and training workshops at various scientific events. Dr. Madfa also regularly attends international conferences and holds administrative positions (Deputy Dean of the Faculty for Students’ & Academic Affairs and Deputy Head of Research Unit).",institutionString:"Thamar University",institution:null},{id:"210472",title:"Dr.",name:"Nermin",middleName:"Mohammed Ahmed",surname:"Yussif",slug:"nermin-yussif",fullName:"Nermin Yussif",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/210472/images/system/210472.jpg",biography:"Dr. Nermin Mohammed Ahmed Yussif is working at the Faculty of dentistry, University for October university for modern sciences and arts (MSA). Her areas of expertise include: periodontology, dental laserology, oral implantology, periodontal plastic surgeries, oral mesotherapy, nutrition, dental pharmacology. She is an editor and reviewer in numerous international journals.",institutionString:"MSA University",institution:null},{id:"204606",title:"Dr.",name:"Serdar",middleName:null,surname:"Gözler",slug:"serdar-gozler",fullName:"Serdar Gözler",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204606/images/system/204606.jpeg",biography:"Dr. Serdar Gözler has completed his undergraduate studies at the Marmara University Faculty of Dentistry in 1978, followed by an assistantship in the Prosthesis Department of Dicle University Faculty of Dentistry. Starting his PhD work on non-resilient overdentures with Assoc. Prof. Hüsnü Yavuzyılmaz, he continued his studies with Prof. Dr. Gürbüz Öztürk of Istanbul University Faculty of Dentistry Department of Prosthodontics, this time on Gnatology. He attended training programs on occlusion, neurology, neurophysiology, EMG, radiology and biostatistics. In 1982, he presented his PhD thesis \\Gerber and Lauritzen Occlusion Analysis Techniques: Diagnosis Values,\\ at Istanbul University School of Dentistry, Department of Prosthodontics. As he was also working with Prof. Senih Çalıkkocaoğlu on The Physiology of Chewing at the same time, Gözler has written a chapter in Çalıkkocaoğlu\\'s book \\Complete Prostheses\\ entitled \\The Place of Neuromuscular Mechanism in Prosthetic Dentistry.\\ The book was published five times since by the Istanbul University Publications. Having presented in various conferences about occlusion analysis until 1998, Dr. Gözler has also decided to use the T-Scan II occlusion analysis method. Having been personally trained by Dr. Robert Kerstein on this method, Dr. Gözler has been lecturing on the T-Scan Occlusion Analysis Method in conferences both in Turkey and abroad. Dr. Gözler has various articles and presentations on Digital Occlusion Analysis methods. He is now Head of the TMD Clinic at Prosthodontic Department of Faculty of Dentistry , Istanbul Aydın University , Turkey.",institutionString:"Istanbul Aydin University",institution:{name:"Istanbul Aydın University",country:{name:"Turkey"}}},{id:"240870",title:"Ph.D.",name:"Alaa Eddin Omar",middleName:null,surname:"Al Ostwani",slug:"alaa-eddin-omar-al-ostwani",fullName:"Alaa Eddin Omar Al Ostwani",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/240870/images/system/240870.jpeg",biography:"Dr. Al Ostwani Alaa Eddin Omar received his Master in dentistry from Damascus University in 2010, and his Ph.D. in Pediatric Dentistry from Damascus University in 2014. Dr. Al Ostwani is an assistant professor and faculty member at IUST University since 2014. \nDuring his academic experience, he has received several awards including the scientific research award from the Union of Arab Universities, the Syrian gold medal and the international gold medal for invention and creativity. Dr. Al Ostwani is a Member of the International Association of Dental Traumatology and the Syrian Society for Research and Preventive Dentistry since 2017. He is also a Member of the Reviewer Board of International Journal of Dental Medicine (IJDM), and the Indian Journal of Conservative and Endodontics since 2016.",institutionString:"International University for Science and Technology.",institution:{name:"Islamic University of Science and Technology",country:{name:"India"}}},{id:"42847",title:"Dr.",name:"Belma",middleName:null,surname:"Işik Aslan",slug:"belma-isik-aslan",fullName:"Belma Işik Aslan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/42847/images/system/42847.jpg",biography:"Dr. Belma IşIk Aslan was born in 1976 in Ankara-TURKEY. After graduating from TED Ankara College in 1994, she attended to Gazi University, Faculty of Dentistry in Ankara. She completed her PhD in orthodontic education at Gazi University between 1999-2005. Dr. Işık Aslan stayed at the Providence Hospital Craniofacial Institude and Reconstructive Surgery in Michigan, USA for three months as an observer. She worked as a specialist doctor at Gazi University, Dentistry Faculty, Department of Orthodontics between 2005-2014. She was appointed as associate professor in January, 2014 and as professor in 2021. Dr. Işık Aslan still works as an instructor at the same faculty. She has published a total of 35 articles, 10 book chapters, 39 conference proceedings both internationally and nationally. Also she was the academic editor of the international book 'Current Advances in Orthodontics'. She is a member of the Turkish Orthodontic Society and Turkish Cleft Lip and Palate Society. She is married and has 2 children. Her knowledge of English is at an advanced level.",institutionString:"Gazi University Dentistry Faculty Department of Orthodontics",institution:null},{id:"178412",title:"Associate Prof.",name:"Guhan",middleName:null,surname:"Dergin",slug:"guhan-dergin",fullName:"Guhan Dergin",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178412/images/6954_n.jpg",biography:"Assoc. Prof. Dr. Gühan Dergin was born in 1973 in Izmit. He graduated from Marmara University Faculty of Dentistry in 1999. He completed his specialty of OMFS surgery in Marmara University Faculty of Dentistry and obtained his PhD degree in 2006. In 2005, he was invited as a visiting doctor in the Oral and Maxillofacial Surgery Department of the University of North Carolina, USA, where he went on a scholarship. Dr. Dergin still continues his academic career as an associate professor in Marmara University Faculty of Dentistry. He has many articles in international and national scientific journals and chapters in books.",institutionString:null,institution:{name:"Marmara University",country:{name:"Turkey"}}},{id:"178414",title:"Prof.",name:"Yusuf",middleName:null,surname:"Emes",slug:"yusuf-emes",fullName:"Yusuf Emes",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178414/images/6953_n.jpg",biography:"Born in Istanbul in 1974, Dr. Emes graduated from Istanbul University Faculty of Dentistry in 1997 and completed his PhD degree in Istanbul University faculty of Dentistry Department of Oral and Maxillofacial Surgery in 2005. He has papers published in international and national scientific journals, including research articles on implantology, oroantral fistulas, odontogenic cysts, and temporomandibular disorders. Dr. Emes is currently working as a full-time academic staff in Istanbul University faculty of Dentistry Department of Oral and Maxillofacial Surgery.",institutionString:null,institution:{name:"Istanbul University",country:{name:"Turkey"}}},{id:"192229",title:"Ph.D.",name:"Ana Luiza",middleName:null,surname:"De Carvalho Felippini",slug:"ana-luiza-de-carvalho-felippini",fullName:"Ana Luiza De Carvalho Felippini",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/192229/images/system/192229.jpg",biography:null,institutionString:"University of São Paulo",institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"256851",title:"Prof.",name:"Ayşe",middleName:null,surname:"Gülşen",slug:"ayse-gulsen",fullName:"Ayşe Gülşen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/256851/images/9696_n.jpg",biography:"Dr. Ayşe Gülşen graduated in 1990 from Faculty of Dentistry, University of Ankara and did a postgraduate program at University of Gazi. \nShe worked as an observer and research assistant in Craniofacial Surgery Departments in New York, Providence Hospital in Michigan and Chang Gung Memorial Hospital in Taiwan. \nShe works as Craniofacial Orthodontist in Department of Aesthetic, Plastic and Reconstructive Surgery, Faculty of Medicine, University of Gazi, Ankara Turkey since 2004.",institutionString:"Univeristy of Gazi",institution:null},{id:"255366",title:"Prof.",name:"Tosun",middleName:null,surname:"Tosun",slug:"tosun-tosun",fullName:"Tosun Tosun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255366/images/7347_n.jpg",biography:"Graduated at the Faculty of Dentistry, University of Istanbul, Turkey in 1989;\nVisitor Assistant at the University of Padua, Italy and Branemark Osseointegration Center of Treviso, Italy between 1993-94;\nPhD thesis on oral implantology in University of Istanbul and was awarded the academic title “Dr.med.dent.”, 1997;\nHe was awarded the academic title “Doç.Dr.” (Associated Professor) in 2003;\nProficiency in Botulinum Toxin Applications, Reading-UK in 2009;\nMastership, RWTH Certificate in Laser Therapy in Dentistry, AALZ-Aachen University, Germany 2009-11;\nMaster of Science (MSc) in Laser Dentistry, University of Genoa, Italy 2013-14.\n\nDr.Tosun worked as Research Assistant in the Department of Oral Implantology, Faculty of Dentistry, University of Istanbul between 1990-2002. \nHe worked part-time as Consultant surgeon in Harvard Medical International Hospitals and John Hopkins Medicine, Istanbul between years 2007-09.\u2028He was contract Professor in the Department of Surgical and Diagnostic Sciences (DI.S.C.), Medical School, University of Genova, Italy between years 2011-16. \nSince 2015 he is visiting Professor at Medical School, University of Plovdiv, Bulgaria. \nCurrently he is Associated Prof.Dr. at the Dental School, Oral Surgery Dept., Istanbul Aydin University and since 2003 he works in his own private clinic in Istanbul, Turkey.\u2028\nDr.Tosun is reviewer in journal ‘Laser in Medical Sciences’, reviewer in journal ‘Folia Medica\\', a Fellow of the International Team for Implantology, Clinical Lecturer of DGZI German Association of Oral Implantology, Expert Lecturer of Laser&Health Academy, Country Representative of World Federation for Laser Dentistry, member of European Federation of Periodontology, member of Academy of Laser Dentistry. Dr.Tosun presents papers in international and national congresses and has scientific publications in international and national journals. He speaks english, spanish, italian and french.",institutionString:null,institution:{name:"Istanbul Aydın University",country:{name:"Turkey"}}},{id:"171887",title:"Prof.",name:"Zühre",middleName:null,surname:"Akarslan",slug:"zuhre-akarslan",fullName:"Zühre Akarslan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/171887/images/system/171887.jpg",biography:"Zühre Akarslan was born in 1977 in Cyprus. She graduated from Gazi University Faculty of Dentistry, Ankara, Turkey in 2000. \r\nLater she received her Ph.D. degree from the Oral Diagnosis and Radiology Department; which was recently renamed as Oral and Dentomaxillofacial Radiology, from the same university. \r\nShe is working as a full-time Associate Professor and is a lecturer and an academic researcher. \r\nHer expertise areas are dental caries, cancer, dental fear and anxiety, gag reflex in dentistry, oral medicine, and dentomaxillofacial radiology.",institutionString:"Gazi University",institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"256417",title:"Associate Prof.",name:"Sanaz",middleName:null,surname:"Sadry",slug:"sanaz-sadry",fullName:"Sanaz Sadry",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/256417/images/8106_n.jpg",biography:null,institutionString:null,institution:null},{id:"272237",title:"Dr.",name:"Pinar",middleName:"Kiymet",surname:"Karataban",slug:"pinar-karataban",fullName:"Pinar Karataban",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/272237/images/8911_n.png",biography:"Assist.Prof.Dr.Pınar Kıymet Karataban, DDS PhD \n\nDr.Pınar Kıymet Karataban was born in Istanbul in 1975. After her graduation from Marmara University Faculty of Dentistry in 1998 she started her PhD in Paediatric Dentistry focused on children with special needs; mainly children with Cerebral Palsy. She finished her pHD thesis entitled \\'Investigation of occlusion via cast analysis and evaluation of dental caries prevalance, periodontal status and muscle dysfunctions in children with cerebral palsy” in 2008. She got her Assist. Proffessor degree in Istanbul Aydın University Paediatric Dentistry Department in 2015-2018. ın 2019 she started her new career in Bahcesehir University, Istanbul as Head of Department of Pediatric Dentistry. In 2020 she was accepted to BAU International University, Batumi as Professor of Pediatric Dentistry. She’s a lecturer in the same university meanwhile working part-time in private practice in Ege Dental Studio (https://www.egedisklinigi.com/) a multidisciplinary dental clinic in Istanbul. Her main interests are paleodontology, ancient and contemporary dentistry, oral microbiology, cerebral palsy and special care dentistry. She has national and international publications, scientific reports and is a member of IAPO (International Association for Paleodontology), IADH (International Association of Disability and Oral Health) and EAPD (European Association of Pediatric Dentistry).",institutionString:null,institution:null},{id:"202198",title:"Dr.",name:"Buket",middleName:null,surname:"Aybar",slug:"buket-aybar",fullName:"Buket Aybar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202198/images/6955_n.jpg",biography:"Buket Aybar, DDS, PhD, was born in 1971. She graduated from Istanbul University, Faculty of Dentistry, in 1992 and completed her PhD degree on Oral and Maxillofacial Surgery in Istanbul University in 1997.\nDr. Aybar is currently a full-time professor in Istanbul University, Faculty of Dentistry Department of Oral and Maxillofacial Surgery. She has teaching responsibilities in graduate and postgraduate programs. Her clinical practice includes mainly dentoalveolar surgery.\nHer topics of interest are biomaterials science and cell culture studies. She has many articles in international and national scientific journals and chapters in books; she also has participated in several scientific projects supported by Istanbul University Research fund.",institutionString:null,institution:null},{id:"260116",title:"Dr.",name:"Mehmet",middleName:null,surname:"Yaltirik",slug:"mehmet-yaltirik",fullName:"Mehmet Yaltirik",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/260116/images/7413_n.jpg",biography:"Birth Date 25.09.1965\r\nBirth Place Adana- Turkey\r\nSex Male\r\nMarrial Status Bachelor\r\nDriving License Acquired\r\nMother Tongue Turkish\r\n\r\nAddress:\r\nWork:University of Istanbul,Faculty of Dentistry, Department of Oral Surgery and Oral Medicine 34093 Capa,Istanbul- TURKIYE",institutionString:null,institution:null},{id:"172009",title:"Dr.",name:"Fatma Deniz",middleName:null,surname:"Uzuner",slug:"fatma-deniz-uzuner",fullName:"Fatma Deniz Uzuner",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/172009/images/7122_n.jpg",biography:"Dr. Deniz Uzuner was born in 1969 in Kocaeli-TURKEY. After graduating from TED Ankara College in 1986, she attended the Hacettepe University, Faculty of Dentistry in Ankara. \nIn 1993 she attended the Gazi University, Faculty of Dentistry, Department of Orthodontics for her PhD education. After finishing the PhD education, she worked as orthodontist in Ankara Dental Hospital under the Turkish Government, Ministry of Health and in a special Orthodontic Clinic till 2011. Between 2011 and 2016, Dr. Deniz Uzuner worked as a specialist in the Department of Orthodontics, Faculty of Dentistry, Gazi University in Ankara/Turkey. In 2016, she was appointed associate professor. Dr. Deniz Uzuner has authored 23 Journal Papers, 3 Book Chapters and has had 39 oral/poster presentations. She is a member of the Turkish Orthodontic Society. 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