Sleep is an ancestral and primitive behaviour, an important part of life thought to be essential for restoration of body and mind. As adults, we spend approximately a third of our lives asleep and as we progress through life there are certain shifts in sleep architecture, most notably in sleep quantity. These biological or physiological age-dependent changes in sleep are well documented , and alongside the shifts in sleep architecture there is an increased susceptibility to certain sleep disorders.
Sleep disturbances and sleep deprivation are common in modern society. Most studies show that since the beginning of the century, populations have been subjected to a steady constant decline in the number of hours devoted to sleep. This is due to changes in a variety of environmental and social conditions (e.g. less dependence on daylight for most activities, extended shift work and 24/7 round-the-clock activities) .
Developments in the fields of molecular genetics, behavioural neuroscience, sleep neurobiology, and the cognitive neurosciences have produced converging evidence of a fundamental role for sleep in cognition. Sleep is required for good mental health, and insufficient sleep has negative effects on mood, cognitive performance and motor function . Cognition is a broad term, which encompasses a variety of mental processes including memory, problem solving, language, forward planning and attention, which can all, be differentially affected by inadequate sleep. This can have serious real-life consequences, where many industries including airlines, long-distance truck driving, manufacturing and emergency services have recognised that sleep deprivation has major effects on performance.
Epidemiologists and clinical neuroscientists have also documented significant links between degree of sleep disturbance and severity of impairment on selective cognitive functions in a variety of clinical populations, including persons at risk for various dementing illnesses [4, 5]. Sleep disorder, in fact, may be one of the earliest signs of neurodegenerative disorders, including early Alzheimer’s disease (AD) .
This chapter will briefly examine the relationship between sleep (quantity and quality) and cognition throughout the life course, and will consider the evidence which suggests that sleep deprivation and sleep disorders are associated with poor cognitive function. More specifically, it will examine the effects that sleep deprivation and sleep disorders have on both amnestic (memory function) and non-amnestic (non-memory function) cognitive processes.
2. Sleep quantity and cognition
Numerous studies have shown that short sleep, long sleep and sleep problems are associated with poorer cognitive function [7-9]. Self-reported short sleep, tiredness and fatigue are more strongly associated with subjective measures of cognitive function than with objective measures . Findings from the Whitehall II study show that adverse changes in sleep over time (decrease from 6, 7 or 8 hours, or increase from 7 or 8 hours) are associated with lower scores on a variety of cognitive function tests, but not memory function . Similarly, a Spanish study found that people who sleep for 11 hours or more per night have significantly lower global cognition scores than those who sleep for 7 hours . A unique study has also reported on the effects of a post-lunch nap on subjective alertness and performance following partial sleep loss. A short nap has been found to improve alertness, sleepiness, short-term memory and accuracy, but does not affect reaction times .
Interestingly, there is little research into the effects of subtle changes in circadian phase on cognition, such as those that commonly occur in the general population after daylight saving time or returning to work after later weekend sleep. One study has revealed that performance on memory and verbal fluency tasks is significantly reduced on Monday morning following delayed weekend sleep . Overall, proper alignment between sleep-wakefulness and internal circadian time may be crucial for cognitive performance, and humans may be very sensitive to small shifts in circadian timing.
The first recorded experiments on sleep deprivation began in the late 19th century , and research into the association between sleep and performance began around 50 years ago . There is now clear evidence that deficits in daytime performance due to sleep loss are associated with a significant social, financial and human cost .
There are two types of sleep loss: acute sleep loss consisting of one continuous extended wake episode, and chronic sleep loss consisting of insufficient sleep over multiple days. A substantial amount of research has been conducted to understand the impact of short-term total sleep deprivation (<48h) on various cognitive domains. A recent meta-analysis examined the effect of sleep deprivation on six cognitive categories (simple attention, complex attention, working memory, processing speed, short-term memory and reasoning) for both speed and accuracy. Generally, effect sizes for each cognitive domain fall along a continuum, with tasks of greater complexity being less susceptible to the effects of total sleep deprivation. Simple attention, or vigilance, is most strongly affected by short-term sleep deprivation, emphasising that this deficit is the one for which compensation is least available. This has implications for tests of work fitness, where deficits in sustained attention could act as an early warning for subsequent cognitive failure in more complex situations .
Therefore, sleep debt can be expressed as an additional wakefulness that has a ‘cost’ (i.e. cognitive impairment), which accumulates over time . Homeostatic physiological processes that occur during sleep can replenish this capacity, but how much sleep is required for satisfactory alertness and performance continues to be debated .
3. Sleep quality and cognition
Whereas sleep quantity is concerned with the amount of time we spend asleep, sleep quality is measured by how well we actually sleep during the night. This is usually assessed via self-reported frequency of nocturnal awakenings; difficulty initiating sleep; waking up early; or waking up feeling tired, using validated tools such as the PSQI . Research has suggested that as well as sleep quantity, sleep quality may also play an important role in cognition. One such study in elderly women has found that disturbed sleep is associated with an increased risk of developing a cognitive impairment, but not with accelerated cognitive decline . However, self-reported poor sleep is not independently related to cognitive function in community-dwelling older men, suggesting that there may be an interplay between sleep quantity and quality which accounts for the detrimental effects on cognitive function . The Maastricht Ageing Study (MAAS) aimed to determine whether subjective sleep complaints (i.e. difficulty falling asleep, waking up too early, and restless or disturbed sleep) in middle aged and older adults predict global cognitive decline over a period of 3 years. The study found that subjective sleep complaints are negatively associated with cognitive performance at follow-up, where waking up too early has the strongest association with cognitive decline of the three sleep quality assessment questions . However, the association between sleep complaints and cognitive decline disappears once depression is controlled for, raising the question of whether poor quality of sleep leads directly to poor cognitive function, or whether poor sleep causes an increase in depressive symptoms which then results in cognitive decline . This finding highlights the importance of accounting for the effects of other variables, such as depression, on sleep and cognitive function when interpreting various study results and potentially contradictory conclusions.
4. Sleep and cognition: A life course perspective
The amount of time we spend asleep fluctuates across the lifespan according to changes associated with age, health and life events. Newborn infants need between 10.5 and 18 hours sleep per day, and this gradually reduces to between 9 and 12 hours by the end of the first year of life , before we settle into a pattern of around 7 to 8 hours sleep per night as adults . Studies indicate that as we age, total sleep quantity, sleep efficiency and deep sleep tend to decline, whereas the incidence of waking after sleep onset tends to increase . More specifically in terms of sleep architecture, the time spent in deep, slow wave sleep (SWS) diminishes, along with a decrease in rapid eye movement (REM) sleep, and the time spent in lighter, stage 1 and stage 2 sleep increases. As a consequence, older people often find it takes longer to fall asleep, have more fragmented sleep, and wake up earlier . Furthermore, ageing is also associated with increased daytime sleep via napping and dozing. Gender and socioeconomic dynamics also play an important role during the life course in determining sleep patterns and their potential effect on health . For example, in women, sleep is affected by life events such as pregnancy and the menopause. In the following sections, we consider the possible effects that these changes in sleeping patterns may have on cognitive function.
4.1. Sleep and cognition in childhood and adolescence
It is well established that sleep plays a vital role in brain maturation and in the development of important cognitive functions, such as memory consolidation and learning . With modern advances in technology, many environmental factors and social activities potentially restrict the time spent sleeping once children and adolescents retire to the bedroom. For example, televisions, mobile phones and computers or video games are becoming common bedroom fixtures .
A typical child spends more time asleep than engaged in any other activity during the 24 hour cycle. As a rule of thumb, the optimal amount of sleep for children is more than 12 hours per night for pre-schoolers, about 12 hours per night for primary school children, and about 9 hours per night thereafter . Between the ages of 3 and 5 years, there is a shift in sleep architecture, with a significant reduction in total sleep time and a decrease in the amount of time spent in ‘deep’ sleep, SWS and REM stages . Further, sleep is distributed across the day until around the age of 5 years, when children shift from a polyphasic to a monophasic sleep pattern, usually due to the changes in daytime schedule associated with attending school . It is commonplace for toddlers and pre-schoolers to engage in midday naps but, until recently, relatively little was known about the function and structure of this sleep period in children. Research has now shown that classroom naps consolidate learning in preschool children, and that the memory loss associated with nap-deprivation is not reversible with overnight sleep . When children are allowed to nap during the day, they recall around 10% more learned material on waking than when tested after an equivalent period of being kept awake. Sleep spindle density in particular is strongly implicated in this memory consolidation process in children, highlighting that the nap does not merely protect the memory from wakeful interference, but that consolidation of learned material is a process unique to sleep . This finding has implications for educational strategies, where scheduled classroom naps could enhance interventions designed to help children achieve academic goals and acquire necessary cognitive skills, with particular relevance to children with a learning delay .
There have been few longitudinal studies of sleep-wake patterns in children [31, 32], and only a small number of studies have investigated sleep behaviours [33, 34]. Therefore, what constitutes normal sleep patterns and normal sleep behaviour during childhood is still debatable. The lack of available data undoubtedly reflects the challenges to studying sleep in children and adolescents, which include reluctance of parents to leave children in the care of unfamiliar adults in laboratory studies, children’s sleep becoming further disrupted in unfamiliar environments, and the potential for increased risk (e.g. fall in school performance, vehicle accidents in young drivers) following sleep restriction studies . However, data from available studies has shown that sleep deprivation has a significant impact on cognitive abilities in children. Children aged between 10 to 14 years who are restricted to only 5 hours sleep show impaired cognitive performance on verbal creativity and the Wisconsin Card Sorting task, in comparison to those allowed to sleep for 11 hours . Similarly, in a further study, children who are allowed to sleep for one hour longer perform significantly better in continuous performance and simple reaction time tests than those who sleep for one hour less, or those who receive no intervention . Longitudinal research has shown that over the course of 3 years, children who experience an increase in sleepiness also show slower improvement in verbal comprehension than children who report lower levels of sleepiness at baseline . The authors highlight the need for interventions to remedy sleep disorders and reduce the deleterious effect on cognition before the transition to puberty .
Circadian rhythms shift developmentally and sleep physiology changes considerably during adolescence (particularly SWS), which may alter the response to sleep restriction . During the weekends, bed times and waking times can change extensively and persistently in children and in adolescents. These shifts are much more likely in adolescence, when the sleep phase rhythm can be seriously disrupted during weekends, and sleep debt is common . Furthermore, the effects of delayed sleep phase in adolescents (characterised by problems with falling asleep and rising at appropriate times) extend into the week, where associations with lower average school grades, and greater incidence of anxiety and depression have been reported . However, the effects of sleep duration on cognition can be different for males and females during the adolescent period. Whilst male adolescents who sleep for 8 hours or more demonstrate higher overall cognitive performance than those sleeping less than 8 hours, there is no association between sleep and cognition for adolescent females . This supports previous findings that cognition is more susceptible to the effects of sleep deprivation in males than in females , and the authors propose that this is also consistent with the evolutionary demands of the female role in child rearing and nurturing .
4.2. Sleep and the elderly
Cognitive ageing is a heterogeneous process, in that not everyone experiences the same rate of decline. Indeed, many neuronal changes associated with cognitive decline begin to appear during middle-age . Biological or physiological age-dependent changes in sleep have been well documented, and include shifts in sleep architecture as well as increased susceptibility to certain sleep disorders . In addition to changes in SWS and REM, electroencephalography (EEG) studies have shown specific changes to delta waves, sleep spindles and K complexes during sleep in the elderly. It has been hypothesized that some of these changes might be early biological markers of the gradual deterioration of the central nervous system with age . Furthermore, chronic ill-health, disability, and pain and discomfort at night may also contribute to poor sleep quality in an ageing population .
Ageing is associated with increased daytime sleep via napping and dozing, due to excessive daytime sleepiness (EDS) or feeling not rested upon awakening [47, 48]. The Medical Research Council Cognitive Function and Ageing Study (CFAS) looked at the association between self-reported sleep measures and cognition in over 2, 000 cognitively unimpaired individuals over the age of 65 years. The authors found that daytime napping at baseline is associated with a lower risk of cognitive decline at 2 and 10 year follow-ups, and that reports of both EDS and obtaining less than 6.5 hours of night-time sleep at baseline are associated with an increased risk of cognitive decline at 10 year follow-up . Sleep structure is also important in aged adults, where the duration of sleep cycles, but not the amount of REM, non-REM or SWS or total sleep time, is positively associated with morning memory performance .
Sleep problems are a common occurrence in those with mild cognitive impairment (MCI)  and dementia . Those with dementia experience highly fragmented sleep, with frequent daytime napping and night-time periods of wakefulness. Furthermore, sleep disorders have been associated with, and are predictive of, cognitive decline , and severity of cognitive impairment in diseases such as dementia and AD [53, 54]. A study has shown that non-demented, Japanese-American men who report EDS at baseline are twice as likely to be diagnosed with incident dementia at 3 year follow-up examination than those without EDS . These findings were replicated in a sample of elderly French men and women , with the cross-cultural validation adding weight to the association between EDS and incident dementia.
Studies have also reported on sleep disturbances in specific types of dementia. In AD, for instance, which is characterized by episodic memory impairment, there are changes in global sleep architecture . Modifications in the stages of sleep, including increased stage 1 sleep and reduced SWS, as well as decreases in sleep spindles, are well documented in dementia and AD [58, 59]. Less time in bed is associated with better cognitive function in AD , whereas EDS is strongly predictive of vascular dementia . Changes in sleep architecture and sleep disturbances are found in a range of other neurodegenerative disorders such as progressive supranuclear palsy, Huntington’s disease (HD), Parkinson’s disease (PD), multiple system atrophy (MSA), dementia with Lewy bodies (DLB) and Creutzfeldt–Jakob disease (CJD) . Only a few studies, however, have investigated the prospective association between sleep architecture and later neurodegenerative disorder. Furthermore, the available results are inconsistent, which may be due to population selection, duration of follow-up, age of participants or type of cognitive impairment .
Pregnant women experience prolonged sleep latency, frequent awakenings, fewer hours of night sleep, and reduced sleep efficiency, which begins in the second trimester of pregnancy and extends through at least the first 2-3 months after delivery [62, 63]. Sleep quality diminishes progressively throughout pregnancy, is most affected immediately after delivery, and then subsequently improves steadily . Whilst many new mothers report feelings of confusion and forgetfulness during the early postpartum period, objective investigations thus far have not provided equivocal results. In some studies, women have significantly lower scores on tasks of immediate memory, complex mental functions (e.g. problem solving) and overall daytime function during the immediate postpartum period, with suggestions that this is influenced by sleep disturbance (e.g. fragmentation, deprivation) [62, 65, 66]. Indeed, although overall cognitive scores may not always differ between new mothers and controls, performance on memory and concentration tasks in postpartum women is significantly predicted by the amount of sleep they had the night before .
Sleep complaints during or after menopause are a common medical problem. Whereas some studies have shown an association between sleepiness, sleep complaints and cognitive performance during and after menopause , other studies have not shown this association . For example, one study showed that both self-reported and objectively-measured disturbed sleep are associated with diminished cognitive function during and after menopause. However, another study has showed that there is a higher association between self-reported poor sleep quality, rather than objectively measured poor sleep quality, and decreased cognitive test performance . Weber et al found that memory complaints in particular are associated with increased sleep disturbance in perimenopausal women . However, it has been suggested that it is age, rather than the menopause
5. Sleep disruption and work
Modern society depends on the continuous operation of a diverse array of crucial services. Thus the 24-hour culture-with shift work, night work, and longer, irregular working hours, and the associated shorter quantity of sleep-is becoming a frequent occurrence throughout the world [71, 72]. Sleep deprivation and consequent disruption of the circadian rhythm is a common situation experienced by individuals in many different professions, such as medical staff. After 8 hours of work, an individual’s performance and ability to concentrate decreases, whilst the risk of fatigue  and cognitive errors increases . Consequently, working at night and working excessive hours that restrict sleep opportunity are implicated in compromised health and safety at work . A combination of factors are involved in this process including age, shift pattern, changes in sleep quality and quantity, sleep disruption and shorter daytime sleep (as compared to the usual night-time sleep), sleepiness and fatigue, and repeated stress induced by desynchronization of the circadian system [76, 77].
Sleepiness in the medical profession is a common occurrence due to the extensive hours worked and disturbed sleep . During a typical shift, physicians perform complex problem solving whilst undertaking a multitude of different tasks. There is extensive research into the effects of sleep deprivation on specific tasks (such as endotracheal intubation and catheterization) , and in many different specialties such as anaesthetics , emergency medicine , surgery or intensive care . A landmark study of medical residents working in an adult intensive care unit shows that residents make more medical errors when they work frequent shifts of at least 24 hours, than when they work shorter shifts . Thus, the effect of sleep deprivation on physicians could have a direct impact on quality of health care.
Subjectively, medical residents report disturbances of sleep, alertness and mood during the night float rotation . Studies have also shown that residents are more likely to have a motor vehicle crash or ‘near miss’ after a night of on-call duty , or after a shift lasting 24 hours or longer . Sleep-deprived residents also have more attention lapses, experience more adverse events and make more diagnostic errors while on duty overnight [86, 87]. From a training perspective, sleep deprivation may affect residents’ skill acquisition and retention.
Aviators and aviation crews are also at a profound risk of sleep deprivation and disturbance given the nature and requirements of their work. Military pilots are required to synthesize vast amounts of information and subsequently make critical decisions. Thus, factors, which may impair cognitive performance, such as fatigue and sleep disruption, must be identified and alleviated wherever possible. A survey of US Army aircrew found that almost 62% of respondents did not feel that they received adequate daytime sleep while on shift . A further study showed that there is a significant positive association between level of effectiveness (as determined by sleep–wake patterns) and neurocognitive functioning before flight operations . In addition, the influence of chronic jet lag on cognitive efficiency in cabin crew has been investigated. Prolonged cortisol elevations (over 8 hours jet lag per week, for more than 3 years) results in a reduced temporal lobe volume within the brain, as well as deficits in spatial learning and memory, which become apparent after just five years of exposure to high cortisol levels .
Alongside studies into the effects of shift work and subsequent sleep disruptions on cognitive function, there has been on-going research into performance enhancers for shift and night workers. Various studies have found that improvements in alertness and performance during night shifts are associated with the use of stimulants such as caffeine  and modafinil [92, 93], and even exposure to bright light . Laboratory and field studies corroborate that scheduled exposure to bright light (for work) and darkness (for sleep) shifts the circadian clock to align completely with a night work/day sleep schedule [95, 96]. As mentioned previously regarding post-lunch naps , short naps may also be useful for improving alertness during night shifts . However, these countermeasures do not address the underlying cause of the problem, which is misalignment between circadian rhythms and the sleep and work schedule.
Few studies have assessed the
6. Sleep and amnestic and non-amnestic cognition
The term ‘cognition’ refers to various higher mental processes, which allow us to think, perceive, remember, imagine and plan ahead in everyday life. These specific processes can be grouped into two broader categories of ‘amnestic’ (memory) and non-amnestic (not involving memory) cognitive function. This is a useful dichotomy when considering age-related cognitive decline and the conversion from normal cognitive ageing to MCI, since MCI is typically diagnosed as amnestic (aMCI) or non-amnestic (naMCI) type . These two types of MCI have different trajectories, with aMCI potentially developing into AD, and naMCI possibly developing into various forms of dementia (e.g. vascular dementia, DLB, frontotemporal dementia) .
Despite the advance in knowledge of MCI subtypes, to date, most studies into the effects of sleep on cognitive function have reported results from tests of ‘global’ cognitive function, such as the Mini-Mental State Exam (MMSE) . Nevertheless, it is possible to distinguish between amnestic and non-amnestic function using the MMSE, as reported recently in a study on sleep characteristics and subsequent cognitive impairment at one-year follow up . In this study, amnestic cognitive impairment is distinguished from non-amnestic impairment by scores on the delayed recall task in the MMSE. That is, if participants cannot recall any of the three items in the memory task, or can only recall one of the items, this is categorised as a failure and thus the participant is attributed with an amnestic cognitive impairment. With regards to sleep quantity, amnestic cognitive impairments at one-year follow up are significantly predicted by long sleep durations (≥ 9 hours) in women, and by short sleep durations (≤ 5 hours) in men. It is possible that women are more resilient to the effects of short sleep due to environmental demands , or that men are more susceptible than women to cognitive impairment following sleep deprivation , although the authors urge that sex differences in these results should in interpreted with caution . That is, males made up a smaller proportion of the sample and so some effects may not be detected due to a lack of statistical power. In addition, there was no association between sleep quantity and non-amnestic function in this sample of community-dwelling older adults.
Gaining knowledge of different predictors of amnestic and non-amnestic cognitive impairment is important, now more than ever, owing to the advances in MCI and dementia research which will eventually allow earlier, and more accurate, diagnoses of cognitive impairments and dementia. Although Potvin et al. (2012) have shown that the MMSE can be used to extract amnestic and non-amnestic cognitive scores; the findings should be interpreted with caution . Relying on the results of one item from a test of global cognition is not a robust method of diagnosing memory impairment, not merely because there are so many more tests, which comprise the non-amnestic score on the MMSE. Further research is now needed to validate and standardise specific tests of amnestic and non-amnestic cognitive function, which will allow more accurate and specific diagnoses of MCI subtypes, thus giving way to earlier detection and diagnoses of dementia and AD, which in turn will improve the level of support provided to patients and their families.
7. Sleep disordered breathing, sleep disorders and cognitive function
The term sleep-disordered breathing (SDB) refers to conditions, which are characterised by intermittent reduction (hypopnoea) or cessation (apnoea) of breathing due to narrowing of the upper airways. These apnoeas and hypopnoeas occur during sleep, causing recurrent arousals from sleep and subsequent EDS. The condition is very common in the elderly, with reports of prevalence rates between 24 and 42% . Each of the two consequences of SDB (sleep fragmentation and hypoxia) is associated with the risk of developing neurocognitive impairments in various domains [5, 104, 105].
7.1. Sleep apnoea
The most common form of sleep apnoea is obstructive sleep apnoea (OSA) or obstructive sleep apnoea syndrome (OSAS). OSAS is associated with frontal lobe and subcortical damage, which in turn is associated with diminished attention span, memory, delayed recall, impaired language and executive functions . Research suggests that the specific brain damage associated with OSAS could therefore increase the risk of developing dementia . Furthermore, a significant positive correlation between the apnoea index (the number of apnoeas occurring per hour) and severity of dementia has also been reported in AD patients . Indeed, SDB may exacerbate cognitive dysfunction in patients with dementia and AD .
The EDS associated with OSAS usually becomes worse as AD progresses. Several studies have suggested a relationship of EDS with the occurrence of dementia [55, 56, 61], but it remains unclear as to whether SDB precedes cognitive impairment or vice versa. It is imperative that the causal associations are established as SDB has a high rate of associated morbidity, and utilisation of established and effective treatments (such as continuous positive airways pressure (CPAP)) might prevent or slow future cognitive decline. For instance, research has shown that treatment of OSA via CPAP improves some aspects of cognitive function in dementia patients as well as in non-demented elderly patients with OSA [109, 110]. However some neurobehavioural deficits, such as impairments in driving performance, may not be reversed by CPAP treatment in patients with severe OSA, and so further research is needed to assess the causes of such impairments .
7.2. Rapid eye movement sleep behaviour disorder (RBD)
RBD is a parasomnia, which is characterized by recurrent dream enactment and loss of normal voluntary muscle atonia during REM sleep, causing excessive motor activity . These movements can cause excessive limb or body jerking leading to complex violent behaviours. RBD is now recognized to be a symptom or prodrome of the group of diseases, which include PD, MSA and DLB . The first study to document this relationship reported that 38% of patients diagnosed with isolated, idiopathic RBD later went on to develop a Parkinsonian disorder after a mean of 12.7 years from RBD onset . Subsequent studies have confirmed similar findings, with typical mean intervals from RBD to PD, DLB, or MSA of around a decade [115-117]. This lengthy preclinical phase has important implications for interventions, which are designed to slow or halt the neurodegenerative process , and could therefore potentially slow the rate of associated cognitive decline.
Insomnia is a commonly reported sleep disorder in Western European countries. It is estimated that between 10% and 35% of the population of Western Europe have varying degrees of insomnia symptoms . Insomnia has been defined in a variety of different ways in epidemiological research, from the presence of any difficulty initiating or maintaining sleep through to validated diagnostic criteria provided by the Diagnostic and Statistical Manual of Mental Disorders , with prevalence rates varying with each definition .
There is a growing amount of literature showing that insomniacs are at increased risk of cognitive decline (see  for a review). One study has shown that insomniacs have decreased memory ability compared to normal sleepers, where the detrimental performance is not attributable to sleepiness . Furthermore, performance deficits in reaction times and vigilance tests often found in insomniacs may be related to specific SWS deficiencies .
The underlying mechanisms regarding the association between sleep and cognition are still relatively poorly understood. However, specific brain regions involved with certain neurocognitive domains, including executive attention, working memory and higher cognitive functions, are known to be particularly vulnerable to sleep deprivation . Furthermore, it has been suggested  that fragmented daytime sleep (following a night shift) is associated with large reductions in activity in the corticothalamic network, which mediates alertness, attention and higher-order cognitive processes. Performing higher-order cognitive tasks, such as decision-making, at night may be reliant on prefrontal brain areas, which suggests either the recruitment of a focused attentional strategy, cortical compensation for sleep deprivation, or both .
Despite decades of research, the significance and functions of sleep and its various stages, in particular REM sleep, are still not fully understood. A close association with cognitive functions was assumed shortly after the discovery of REM sleep and its relationship to dreaming  and there is now considerable evidence showing that newly learned material and skills are consolidated during REM sleep . Furthermore, studies show a link between brain cholinergic activity, timing and density of REM sleep and cognitive functioning . Thus, deficiencies of REM sleep might correlate with or predict cognitive deficits in the elderly.
Research linking SWS to mental restorative processes has been somewhat limited and less convincing. Only a few studies have attempted to examine the relationship between nocturnal SWS and subsequent daytime performance. In one study of healthy young male subjects, those who had slower reaction times on a daytime vigilance test also had lower amounts of nocturnal SWS than did age-and gender-matched individuals who had relatively faster reaction times . Further to findings of the importance of SWS to daytime performance in younger people, Spiegel et al. report both confirmatory and contradictory results concerning the associations between loss of SWS and cognitive decline in adult life. They speculate that the role or functional significance of SWS may change over the course of the life span, which could account for their inconsistent findings, where SWS plays a restorative role in the cognitive functioning of older adults . It is however possible that these studies are measuring different aspects of SWS and that the observed differences may reflect a lack of resolution in the available measurements.
The formation of long-term memories requires a process of consolidation, which is facilitated by sleep. The formation of declarative (consciously recalled) memories, which are hippocampus-dependent, appears to benefit mainly from SWS . Recently, the focus has also been placed on stage 2 sleep and more precisely on sleep spindles, where research shows that overnight verbal memory retention is highly correlated with an increase in the number of sleep spindles .
Substantial inter-individual differences in vulnerability to the effects of sleep loss have been demonstrated by various studies . These differences are partly due to tolerance of disturbances in circadian and social rhythm, which varies considerably between individuals . There is also substantial individual variability in the magnitude of age-related cognitive decline . Suggested sources for this variability focus on individual differences in the amount of age associated brain dysfunction, such as cortical , white matter pathology , and reductions in neurotransmitter receptor binding .
Sleep deprivation, mental fatigue, depression, or sleep disorders such as narcolepsy may result in an individual experiencing a transient loss of perception of external stimuli. This is known as a microsleep, and may last up to 30 seconds . Microsleeps can occur at any time without warning, and the sufferer is usually unaware of the occurrence. As such, microsleeps are extremely dangerous in situations that require constant attention or vigilance, such as driving or operating heavy machinery . Through a combination of EEG and neuroimaging techniques, research has shown that there are distinct and localised increases in activity in the fronto-parietal cortex which accompany microsleeps . This activity may be part of a mechanism to restore responsiveness during the transient loss of arousal. Positron Emission Tomography (PET) studies have also confirmed that the ‘resting brain’ is surprisingly active. Raichle and Mintun (2006) report that, not only are there specific areas of the brain associated with higher regional cerebral blood flow (rCBF) during rest than during attention-demanding tasks, but that attention-demanding tasks are associated with just a 10% increase in global brain metabolism compared to periods of rest . The Default Mode Network (DMN) is responsible for the default state of ‘resting’ brain activity, which is vital for brain functioning and possibly consciousness . The DMN comprises the posterior and anterior cingulate cortex, and the temporo-parietal cortex , where activity decreases during attention-demanding tasks and increases when no such tasks are preformed (i.e. during rest) . Interestingly, Picchioni et al. (2008) also found a transient increase in activity within the DMN during early stage 1 sleep .
Closely related to the DMN is the process of ‘mind wandering’ (or daydreaming), which is described as the default mode of operation of the brain . It has been argued that rather than being a passive process, mind wandering is vital to healthy cognition, for example by integrating past and present experiences to facilitate future planning and personal goal resolution . There has been speculation regarding the similarity between thought processes involved in mind wandering during wakeful periods and dream mentation during sleep , encouraging a more scientific enquiry into whether daydreaming and dreaming are mediated by the same neural networks. Indeed, meta-analyses of neuroimaging data show overlaps in activation of areas of the DMN during mind wandering, and dreaming during REM sleep .
9. Public health importance
There is no doubt that sleep is an integral part of life, and many studies have suggested that it should not be overlooked by clinicians, especially in older adults. Studies have shown that poor sleep quality can be an early sign of amnestic cognitive decline  and that EDS may be an early marker and potentially reversible risk factor of cognitive decline and onset of dementia .
Cognitive failures associated with total sleep deprivation are of great interest and importance, as their real-world consequences are often catastrophic [149, 150]. Night work is associated with safety risks for both the individual worker as well as society [149, 151]. Deficits in many aspects of cognition such as decision-making, memory processes and importantly in sustained attention are implicated in errors and accidents . Diminished alertness during night shifts has been linked to ability to drive a motor vehicle, which can result in accidents [80, 85, 152]. There is also evidence that air traffic controller (ATC) performance declines and error rates increase on the night-shift, and that ATCs may be falling asleep while on-duty . This, together with the evidence that flying performance decrements occur due to fatigue , poses a real worry. Considerable controversy exists regarding optimal work hours for physicians and surgeons, especially those in training . There is a trade-off between providing a continuity of care; educational opportunities; and traditionally defined professionalism vs. clinicians’ fatigue and health; erroneous decision-making and performance; patient care and safety; and overall cost of health care [152, 155].
The implementation of the European Working Time Directive (EWTD) has dramatically shortened doctors’ working hours in an effort to reduce resident fatigue, with the anticipated result of decreasing fatigue-related medical errors and improving residents’ well-being . Following the implementation of these regulations, increasing attention has been focused on the role of resident physicians’ fatigue and the occurrence of medical errors, percutaneous needle sticks, laceration injuries and post-call motor vehicle crashes . Although certain aspects remain controversial, there seems to be a positive effect on residents’ fatigue levels, quality of life and job satisfaction, which may positively influence patient safety [158, 159]. Despite these changes, long working hours remain a common feature in health care worldwide . An evidence-based approach is needed to minimize the risk that current work hour practices bestow while optimizing education and continuity of care .
Research shows that the effect of sleep deprivation on cognition is an important public health issue. Results of these studies have important implications in many areas of society, from new policies in medical education  to flight psychologists, improving overall sleep patterns and enhancing the war-fighting efforts of aviators in combat . Understanding the fundamental properties and mechanisms through which sleep disruption and sleep disorders are related to cognition, and how sleep regulates alertness and performance in humans, also has therapeutic implications for the development of treatment and prevention strategies, as well as novel wake-promoting therapies .
Studies to date suggest that sufficient quantity and quality of sleep are required for many aspects of amnestic and non-amnestic cognition, most notably executive attention, working memory and higher cognitive functions. The amount of sleep required continues to be debated, but it is generally agreed that people at the extremes of the sleep distribution, i.e. short (<5hr) and long (>9hr) sleepers , are subject to cognitive deficits and accelerated cognitive ageing. Proper alignment between sleep-wakefulness and internal circadian time is crucial for optimal cognitive performance.
A vast amount of research has been conducted into the effect of sleep on cognition in specific scenarios as highlighted in this review. Shift workers who may have shortened sleep patterns have been implicated in compromised health and safety at work due to cognitive deficits. Furthermore, during pregnancy, postpartum and the menopause, women are vulnerable to sleep disturbances, which can have profound effects on different areas of cognition, most notably memory. Age-dependent changes in sleep have been well documented, and research has been conducted into the association between these changes and effects on normal and pathological cognitive decline. Sleep disorders have also been shown to negatively affect cognitive function across the lifespan.
Further research is required to understand the associations and mechanisms involved in more detail, where the findings could have huge impacts in many areas of medicine, from normal ageing to neurocognitive disorders and public health.
The study is part of the
Bliwise DL. Normal aging. Principles and practice of sleep medicine. Forth ed. Philadelphia: WB Saunders Company; 2005. p. 24-38.
Cappuccio FP, Miller MA, Lockley SW. Sleep, health, and society: the contribution of epidemiology. In: Cappuccio FP, Miller MA, Lockley SW, editors. Sleep, Health, and Society: From Aetiology to Public Health. 1 ed. Oxford: OUP; 2010. p. 1-8.
Durmer JS, Dinges DF. Neurocognitive consequences of sleep deprivation. Semin Neurol 2005;25(01):117-29.
Claassen DO, Josephs KA, Ahlskog JE, Silber MH, Tippmann-Peikert M, Boeve BF. REM sleep behavior disorder preceding other aspects of synucleinopathies by up to half a century. Neurology 2010;75(6):494-9.
Yaffe K, Laffan AM, Harrison SL, Redline S, Spira AP, Ensrud KE, et al. Sleep-disordered breathing, hypoxia, and risk of mild cognitive impairment and dementia in older women. JAMA: The Journal of the American Medical Association 2011;306(6):613-9.
Rauchs GA, Schabus M, Parapatics S, Bertran Fo, Clochon P, Hot P, et al. Is there a link between sleep changes and memory in Alzheimer's disease? Neuroreport 2008;19(11):1159-62.
Kronholm E, Sallinen M, Suutama T, Sulkava R, Era P, Partonen T. Self-reported sleep duration and cognitive functioning in the general population. Journal of Sleep Research 2009;18(4):436-46.
Nebes RD, Buysse DJ, Halligan EM, Houck PR, Monk TH. Self-reported sleep quality predicts poor cognitive performance in healthy older adults. The Journals of Gerontology Series B: Psychological Sciences and Social Sciences 2009;64(2):180-7.
Xu L, Jiang CQ, Lam TH, Liu B, Jin YL, Zhu T, et al. Short or long sleep duration is associated with memory impairment in older Chinese: the Guangzhou Biobank Cohort Study. Sleep 2011;34(5):575-80.
Ferrie JE, Shipley MJ, Akbaraly TN, Marmot MG, Kivimaki M, Singh-Manoux A. Change in sleep duration and cognitive function: findings from the Whitehall II Study. Sleep 2011;34(5):565-73.
Faubel R, Lopez-Garcia E, Guallar-Castillon P, Graciani A, Banegas JR, Rodriguez-Artalego F. Usual sleep duration and cognitive function in older adults in Spain. Journal of Sleep Research 2009;18(4):427-35.
Waterhouse J, Atkinson G, Edwards B, Reilly T. The role of a short post-lunch nap in improving cognitive, motor, and sprint performance in participants with partial sleep deprivation. Journal of Sports Sciences 2007;25(14):1557-66.
Yang CM, Spielman AJ. The effect of a delayed weekend sleep pattern on sleep and morning functioning. Psychology and Health 2001;16(6):715-25.
Patrick GTW, Gilbert JA. Studies from the psychological laboratory of the University of Iowa: On the effects of loss of sleep. Psychological Review 1896;3(5):469-83.
Wilkinson RT. Interaction of lack of sleep with knowledge of results, repeated testing, and individual differences. J Exp Psychol 1961;62:263-71.
Lim J, Dinges DF. A meta-analysis of the impact of short-term sleep deprivation on cognitive variables. Psychological Bulletin 2010;136(3):375-89.
Van Dongen HP, Maislin G, Mullington JM, Dinges DF. The cumulative cost of additional wakefulness: dose-response effects on neurobehavioral functions and sleep physiology from chronic sleep restriction and total sleep deprivation. Sleep 2003 Mar 15;26(2):117-26.
Cohen DA, Wang W, Wyatt JK, Kronauer RE, Dijk DJ, Czeisler CA, et al. Uncovering residual effects of chronic sleep loss on human performance. Science Translational Medicine 2010;2(14):14ra3.
Buysse DJ, Reynolds CF 3rd, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res 1989 May;28(2):193-213.
Tworoger SS, Lee S, Schernhammer ES, Grodstein F. The association of self-reported sleep duration, difficulty sleeping, and snoring with cognitive function in older women. Alzheimer Dis Assoc Disord 2006;20(1):41-8.
Blackwell T, Yaffe K, Ancoli-Israel S, Redline S, Ensrud KE, Stefanick ML, et al. Association of sleep characteristics and cognition in older community-dwelling men: the MrOS sleep study. Sleep 2011 Oct;34(10):1347-56.
Jelicic M, Bosma H, Ponds RWHM, Van Boxtel MPJ, Houx PJ, Jolles J. Subjective sleep problems in later life as predictors of cognitive decline. Report from the Maastricht Ageing Study (MAAS). International Journal of Geriatric Psychiatry 2002;17(1):73-7.
National Sleep Foundation. How Much Sleep Do We Really Need? 2013. 30-6-2013.
Bixler E. Sleep and society: an epidemiological perspective. Sleep Med 2009 Sep;10 Suppl 1:S3-S6.
Hislop J, Arber S. Sleep, Gender, and Aging. In: Calsanti TM, Selvin KL, editors. Age Matters: Re-Aligning Feminist Thinking.New York: Routledge; 2006. p. 225-46.
Spruyt K, Gozal D. Sleep in children: the evolving challenge of catching enough and quality Zzz's. In: Cappuccio FP, Miller MA, Lockley SW, editors. Sleep, Health and Society: From Aetiology to Public Health. 1st ed. Oxford: OUP; 2010. p. 215-38.
Li S, Jin X, Wu S, Jiang F, Yan C, Shen X. The impact of media use on sleep patterns and sleep disorders among school-aged children in China. Sleep 2007 Mar;30(3):361-7.
Ohayon MM, Carskadon MA, Guilleminault C, Vitiello MV. Meta-analysis of quantitative sleep parameters from childhood to old age in healthy individuals: developing normative sleep values across the human lifespan. Sleep 2004 Nov 1;27(7):1255-73.
Weissbluth M. Naps in children: 6 months-7 years. Sleep 1995 Feb;18(2):82-7.
Kurdziel L, Duclos K, Spencer RMC. Sleep spindles in midday naps enhance learning in preschool children. Proc Natl Acad Sci USA2013 Oct 22;110(43):17267-72.
Thorleifsdottir B, Bjornsson JK, Benediktsdottir B, Gislason T, Kristbjarnarson H. Sleep and sleep habits from childhood to young adulthood over a 10-year period. J Psychosom Res 2002 Jul;53(1):529-37.
Iglowstein I, Jenni OG, Molinari L, Largo RH. Sleep duration from infancy to adolescence: reference values and generational trends. Pediatrics 2003 Feb;111(2):302-7.
Iglowstein I, Latal HB, Molinari L, Largo RH, Jenni OG. Sleep behaviour in preterm children from birth to age 10 years: a longitudinal study. Acta Paediatr 2006 Dec;95(12):1691-3.
Jenni OG, Fuhrer HZ, Iglowstein I, Molinari L, Largo RH. A longitudinal study of bed sharing and sleep problems among Swiss children in the first 10 years of life. Pediatrics 2005 Jan;115(1 Suppl):233-40.
Beebe DW. Cognitive, behavioral, and functional consequences of inadequate sleep in children and adolescents. Pediatr Clin North Am 2011 Jun;58(3):649-65.
Randazzo AC, Muehlbach MJ, Schweitzer PK, Walsh JK. Cognitive function following acute sleep restriction in children ages 10-14. Sleep 1998 Dec 15;21(8):861-8.
Sadeh A, Gruber R, Raviv A. The effects of sleep restriction and extension on school-age children: what a difference an hour makes. Child Dev 2003 Mar;74(2):444-55.
Bub KL, Buckhalt JA, El-Sheikh M. Children's sleep and cognitive performance: a cross-domain analysis of change over time. Dev Psychol 2011 Nov;47(6):1504-14.
Campbell IG, Higgins LM, Trinidad JM, Richardson P, Feinberg I. The increase in longitudinally measured sleepiness across adolescence is related to the maturational decline in low-frequency EEG power. Sleep 2007 Dec;30(12):1677-87.
Crowley SJ, Acebo C, Carskadon MA. Sleep, circadian rhythms, and delayed phase in adolescence. Sleep Med 2007 Sep;8(6):602-12.
Saxvig IW, Pallesen S, Wilhelmsen-Langeland A, Molde H, Bjorvatn B. Prevalence and correlates of delayed sleep phase in high school students. Sleep Med 2012 Feb;13(2):193-9.
Ortega FB, Ruiz JR, Castillo R, Chillon P, Labayen I, Martinez-Gomez D, et al. Sleep duration and cognitive performance in adolescence. The AVENA study. Acta Paediatr 2010 Mar;99(3):454-6.
Alhola P, Polo-Kantola P. Sleep deprivation: Impact on cognitive performance. Neuropsychiatr Dis Treat 2007;3(5):553-67.
Salthouse TA. When does age-related cognitive decline begin? Neurobiology of Aging 2009;30(4):507-14.
Prinz PN, Peskind ER, Vitaliano PP, Raskind MA, Eisdorfer C, Zemcuznikov N, et al. Changes in the sleep and waking EEGs of nondemented and demented elderly subjects. Journal of the American Geriatrics Society 1982;30(2):86-93.
Stewart R, Besset A, Bebbington P, Brugha T, Lindesay J, Jenkins R, et al. Insomnia comorbidity and impact and hypnotic use by age group in a national survey population aged 16 to 74 years. Sleep 2006;29(11):1391-7.
Buysse DJ, Reynolds CF, Monk TH, Hoch CC. Quantification of subjective sleep quality in healthy elderly men and women using the Pittsburgh Sleep Quality Index (PSQI). Sleep: Journal of Sleep Research & Sleep Medicine 1991; 14(4):331-8.
Vaz Fragoso CA, Gill TM. Sleep complaints in community-living older persons: a multifactorial geriatric syndrome. Journal of the American Geriatrics Society 2007;55(11):1853-66.
Keage HAD, Banks S, Yang KL, Morgan K, Brayne C, Matthews FE. What sleep characteristics predict cognitive decline in the elderly? Sleep Medicine 2012;13(7):886-92.
Mazzoni G, Gori S, Formicola G, Gneri C, Massetani R, Murri L, et al. Word recall correlates with sleep cycles in elderly subjects. Journal of Sleep Research 1999;8(3):185-8.
van der Linde R, Stephan BC, Matthews FE, Brayne C, Savva GM. Behavioural and psychological symptoms in the older population without dementia-relationship with socio-demographics, health and cognition. BMC Geriatr 2010;10:87.
Bliwise DL. Sleep in normal aging and dementia. Sleep: Journal of Sleep Research & Sleep Medicine 1993;16(1):40-81.
Merlino G, Piani A, Gigli GL, Cancelli I, Rinaldi A, Baroselli A, et al. Daytime sleepiness is associated with dementia and cognitive decline in older Italian adults: a population-based study. Sleep Med 2010 Apr;11(4):372-7.
Bonanni L, Thomas A, Tiraboschi P, Perfetti B, Varanese S, Onofrj M. EEG comparisons in early Alzheimer's disease, dementia with Lewy bodies and Parkinson's disease with dementia patients with a 2-year follow-up. Brain 2008;131(3):690-705.
Foley D, Monjan A, Masaki K, Ross W, Havlik R, White L, et al. Daytime sleepiness is associated with 3-year incident dementia and cognitive decline in older Japanese-American men. J Am Geriatr Soc 2001;49(12):1628-32.
Jaussent I, Bouyer J, Ancelin ML, Berr C, Foubert-Samier A, Ritchie K, et al. Excessive sleepiness is predictive of cognitive decline in the elderly. Sleep 2012;35(9):1201-7.
Petit D, Gagnon JF, Fantini ML, Ferini-Strambi L, Montplaisir J. Sleep and quantitative EEG in neurodegenerative disorders. Journal of Psychosomatic Research 2004;56(5):487-96.
Loewenstein RJ, Weingartner H, Gillin JC, Kaye W, Ebert M, Mendelson WB. Disturbances of sleep and cognitive functioning in patients with dementia. Neurobiology of Aging 1983;3(4):371-7.
Reynolds CF 3rd, Kupfer DJ, Taska LS, Hoch CC, Spiker DG, Sewitch DE, et al. EEG sleep in elderly depressed, demented, and healthy subjects. Biological Psychiatry 1985;20(4):431-42.
Tractenberg RE, Singer CM, Kaye JA. Symptoms of sleep disturbance in persons with Alzheimer's disease and normal elderly. J Sleep Res 2005;14(2):177-85.
Elwood PC, Bayer AJ, Fish M, Pickering J, Mitchell C, Gallacher JEJ. Sleep disturbance and daytime sleepiness predict vascular dementia. Journal of Epidemiology and Community Health 2011;65(9):820-4.
Insana SP, Stacom EE, Montgomery-Downs HE. Actual and perceived sleep: Associations with daytime functioning among postpartum women. Physiology &Behavior 2011;102(2):234-8.
Swain AM, O’Hara MW, Starr KR, Gorman LL. A prospective study of sleep, mood, and cognitive function in postpartum and nonpostpartum women. Obstetrics & Gynecology 1997;90(3):381-6.
Montgomery-Downs HE, Insana SP, Clegg-Kraynok MM, Mancini LM. Normative longitudinal maternal sleep: the first 4 postpartum months. American Journal of Obstetrics and Gynecology 2010;203(5):465-81.
Eidelman AI, Hoffmann NW, Kaitz M. Cognitive deficits in women after childbirth. Obstetrics and Gynecology 1993;81(5):764-7.
Insana SP, Williams KB, Montgomery-Downs HE. Sleep disturbance and neurobehavioral performance among postpartum women. Sleep 2013;36(1):73-81.
Greendale GA, Wight RG, Huang MH, Avis N, Gold EB, Joffe H, et al. Menopause-associated symptoms and cognitive performance: Results from the study of Women's Health Across the Nation. American Journal of Epidemiology 2010;171(11):1214-24.
Kalleinen N, Polo-Kantola PA, Himanen SL, Alhola P, Joutsen A, Urrila AS, et al. Sleep and the menopause-do postmenopausal women experience worse sleep than premenopausal women? Menopause International 2008;14(3):97-104.
Regestein QR, Friebely J, Shifren JL, Scharf MB, Wiita B, Carver J, et al. Self-reported sleep in postmenopausal women. Menopause 2004;11(2):198-207.
Weber MT, Mapstone M, Staskiewicz J, Maki PM. Reconciling subjective memory complaints with objective memory performance in the menopausal transition. Menopause 2012;19(7):735-41.
Bliwise DL. Historical change in the report of daytime fatigue. Sleep 1996;19(6):462-4.
Harma M, Kandolin I. Shiftwork, age and well-being: recent developments and future perspectives. Journal of Human Ergology 2001;30(1-2):287-93.
Dawson D, Reid K. Fatigue, alcohol and performance impairment. Nature 1997;388(6639):235.
Poissonnet CMl, Véron M. Health effects of work schedules in healthcare professions. Journal of Clinical Nursing 2000;9(1):13-23.
Spurgeon A, Harrington JM, Cooper CL. Health and safety problems associated with long working hours: a review of the current position. Occupational and Environmental Medicine 1997;54(6):367-75.
Akerstedt T. Shift work and disturbed sleep/wakefulness. Occupational Medicine 2003;53(2):89-94.
Bonnefond A, Harma M, Hakola T, Sallinen M, Kandolin I, Virkkala J. Interaction of age with shift-related sleep-wakefulness, sleepiness, performance, and social life. Experimental Aging Research 2006;32(2):185-208.
Asaiag PE, Perotta B, Martins MdA, Tempski Pc. Quality of life, daytime sleepiness, and burnout in medical residents. Revista Brasileira de Educacao Médica 2010;34(3):422-9.
Storer JS, Floyd HH, Gill WL, Giusti CW, Ginsberg H. Effects of sleep deprivation on cognitive ability and skills of pediatrics residents. Academic Medicine 1989;64(1):29-32.
Murray D, Dodds C. The effect of sleep disruption on performance of anaesthetists-A pilot study. Anaesthesia 2003;58(6):520-5.
Machi MS, Staum M, Callaway CW, Moore C, Jeong K, Suyama J, et al. The relationship between shift work, sleep, and cognition in career emergency physicians. Academic Emergency Medicine 2012;19(1):85-91.
Veasey S, Rosen R, Barzansky B, Rosen I, Owens J. Sleep loss and fatigue in residency training. JAMA: The Journal of the American Medical Association 2002;288(9):1116-24.
Landrigan CP, Rothschild JM, Cronin JW, Kaushal R, Burdick E, Katz JT, et al. Effect of reducing interns' work hours on serious medical errors in intensive care units. New England Journal of Medicine 2004;351(18):1838-48.
Cavallo A, Ris MD, Succop P. The night float paradigm to decrease sleep deprivation: good solution or a new problem? Ergonomics 2003;46(7):653-63.
Geer RT, Jobes DR, Tew JD, Stepsis LH. Incidence of automobile accidents involving anesthesia residents after on-call duty cycles.Anesthesiology1997;87(3):A938.
Lockley SW, Landrigan CP, Barger LK, Czeisler CA. When policy meets physiology: the challenge of reducing resident work hours. Clinical Orthopaedics and Related Research 2006;449:116-27.
Barger LK, Ayas NT, Cade BE, Cronin JW, Rosner B, Speizer FE, et al. Impact of extended-duration shifts on medical errors, adverse events, and attentional failures. PLoS Medicine 2006;3(12):e487.
Caldwell JL, Gilreath SR. Work and sleep hours of US Army aviation personnel working reverse cycle. Military Medicine 2001;166(2):159-66.
Rabinowitz YG, Breitbach JE, Warner CH. Managing aviator fatigue in a deployed environment: the relationship between fatigue and neurocognitive functioning. Military Medicine 2009;174(4):358-62.
Cho K. Chronic'jet lag'produces temporal lobe atrophy and spatial cognitive deficits. Nature Neuroscience 2001;4(6):567-8.
Schweitzer PK, Randazzo AC, Stone K, Erman M, Walsh JK. Laboratory and field studies of naps and caffeine as practical countermeasures for sleep-wake problems associated with night work. Sleep 2006;29(1):39-50.
Walsh JK, Randazzo AC, Stone KL, Schweitzer PK. Modafinil improves alertness, vigilance, and executive function during simulated night shifts. Sleep 2004 May 1;27(3):434-9.
Czeisler CA, Walsh JK, Roth T, Hughes RJ, Wright KP, Kingsbury L, et al. Modafinil for excessive sleepiness associated with shift-work sleep disorder. New England Journal of Medicine 2005;353(5):476-86.
Campbell SS, Dijk DJ, Boulos Z, Eastman CI, Lewy AJ, Terman M. Light treatment for sleep disorders: consensus report. III. Alerting and activating effects. J Biol Rhythms 1995 Jun;10(2):129-32.
Boivin DB, James FO. Circadian adaptation to night-shift work by judicious light and darkness exposure. J Biol Rhythms 2002 Dec;17(6):556-67.
Dawson D, Encel N, Lushington K. Improving adaptation to simulated night shift: timed exposure to bright light versus daytime melatonin administration. Sleep 1995 Jan;18(1):11-21.
Virtanen M, Singh-Manoux A, Ferrie JE, Gimeno D, Marmot MG, Elovainio M, et al. Long working hours and cognitive function The Whitehall II Study. American Journal of Epidemiology 2009;169(5):596-605.
Rouch I, Wild P, Ansiau D, Marquie JC. Shiftwork experience, age and cognitive performance. Ergonomics 2005;48(10):1282-93.
Petersen RC. Mild cognitive impairment as a diagnostic entity. J Intern Med 2004 Sep;256(3):183-94.
Sachdev PS, Lipnicki DM, Crawford J, Reppermund S, Kochan NA, Trollor JN, et al. Risk profiles of subtypes of mild cognitive impairment: the sydney memory and ageing study. J Am Geriatr Soc 2012 Jan;60(1):24-33.
Folstein MF, Folstein SE, McHugh PR. "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975 Nov;12(3):189-98.
Potvin O, Lorrain D, Forget H, Dubé M, Grenier S, Préville M, et al. Sleep quality and 1-year incident cognitive impairment in community-dwelling older adults. Sleep 2012;35(4):491-9.
Ancoli-Israel S, Ayalon L. Diagnosis and treatment of sleep disorders in older adults. Am J Geriatr Psychiatry 2006 Feb;14(2):95-103.
Ancoli-Israel S, Kripke DF, Klauber MR, Mason WJ, Fell R, Kaplan O. Sleep-disordered breathing in community-dwelling elderly. Sleep 1991;14(6): 486-95.
Ancoli-Israel S, Klauber MR, Butters N, Parker L. Dementia in institutionalized elderly: relation to sleep apnea. Journal of the American Geriatrics Society 1991Mar; 39(3): 258-63.
Macey PM, Henderson LA, Macey KE, Alger JR, Frysinger RC, Woo MA, et al. Brain morphology associated with obstructive sleep apnea. American Journal of Respiratory and Critical Care Medicine 2002;166(10):1382-7.
Kim SJ, Lee JH, Lee DY, Jhoo JH, Woo JI. Neurocognitive dysfunction associated with sleep quality and sleep apnea in patients with mild cognitive impairment. American Journal of Geriatric Psych 2011;19(4):374-81.
Hoch CC, Reynolds CF 3rd, Kupfer DJ, Houck PR, Berman SR, Stack JA. Sleep-disordered breathing in normal and pathologic aging. The Journal of Clinical Psychiatry 1986;47(10):499-503.
Ancoli-Israel S, Palmer BW, Cooke JR, Corey-Bloom J, Fiorentino L, Natarajan L, et al. Cognitive effects of treating obstructive sleep apnea in Alzheimer's disease: a randomized controlled study. J Am Geriatr Soc 2008 Nov;56(11):2076-81.
Weaver TE, Chasens ER. Continuous positive airway pressure treatment for sleep apnea in older adults. Sleep Med Rev 2007 Apr;11(2):99-111.
Vakulin A, Baulk SD, Catcheside PG, Antic NA, van den Heuvel CJ, Dorrian J, McEvoy RD. Driving simulator performance remains impaired in patients with severe OSA after CPAP treatment. J Clin Sleep Med;7(3):246-53.
Boeve BF, Silber MH, Saper CB, Ferman TJ, Dickson DW, Parisi JE, et al. Pathophysiology of REM sleep behaviour disorder and relevance to neurodegenerative disease. Brain 2007;130(11):2770-88.
Claassen DO, Josephs KA, Ahlskog JE, Silber MH, Tippmann-Peikert M, Boeve BF. REM sleep behavior disorder preceding other aspects of synucleinopathies by up to half a century. Neurology 2010;75(6):494-9.
Schenck CH, Bundlie SR, Mahowald MW. Delayed emergence of a parkinsonian disorder in 38% of 29 older men initially diagnosed with idiopathic rapid eye movement sleep behavior disorder. Neurology 1996;46(2):388-93.
Boeve BF, Silber MH, Parisi JE, Dickson DW, Ferman TJ, Benarroch EE, et al. Synucleinopathy pathology and REM sleep behavior disorder plus dementia or parkinsonism. Neurology 2003;61(1):40-5.
Postuma RB, Gagnon JF, Vendette M, Fantini ML, Massicotte-Marquez J, Montplaisir J. Quantifying the risk of neurodegenerative disease in idiopathic REM sleep behavior disorder. Neurology 2009;72(15):1296-300.
Postuma RB, Gagnon JF, Vendette M, Montplaisir JY. Idiopathic REM sleep behavior disorder in the transition to degenerative disease. Mov Disord 2009;24(15):2225-32.
Ohayon MM, Partinen M. Insomnia and global sleep dissatisfaction in Finland. Journal of Sleep Research 2002;11(4):339-46.
Diagnostic and statistical manual of mental disorders (4th Ed., text rev.). 4th ed. 2001.
Ohayon MM. Epidemiology of insomnia: what we know and what we still need to learn. Sleep Medicine Reviews 2002;6(2):97-111.
Fortier-Brochu E, Beaulieu-Bonneau S, Ivers H, Morin CM. Insomnia and daytime cognitive performance: a meta-analysis. Sleep Med Rev 2012 Feb;16(1):83-94.
Bonnet MH, Arand DL. 24-Hour metabolic rate in insomniacs and matched normal sleepers. Sleep 1995;18(7):581-8.
Crenshaw MC, Edinger JD. Slow-wave sleep and waking cognitive performance among older adults with and without insomnia complaints. Physiology &Behavior 1999;66(3):485-92.
Naughton PA, Aggarwal R, Wang TT, Van Herzeele I, Keeling AN, Darzi AW, et al. Skills training after night shift work enables acquisition of endovascular technical skills on a virtual reality simulator. Journal of Vascular Surgery 2011;53(3):858-66.
Leff DR, Orihuela-Espina F, Athanasiou T, Karimyan V, Elwell C, Wong J, et al. Circadian Cortical Compensation: A Longitudinal Study of Brain Function During Technical and Cognitive Skills in Acutely Sleep-Deprived Surgical Residents. Annals of Surgery 2010;252(6):1082-90.
Dement W, Kleitman N. Cyclic variations in EEG during sleep and their relation to eye movements, body motility, and dreaming. Electroencephalography and Clinical Neurophysiology 1957;9(4):673-90.
Karni A, Tanne D, Rubenstein BS, Askenasy JJ, Sagi D. Dependence on REM sleep of overnight improvement of a perceptual skill. Science 1994;265(5172):679-82.
Spiegel R, Herzog A, Koberle S. Polygraphic sleep criteria as predictors of successful aging: an exploratory longitudinal study. Biological Psychiatry 1999;45(4):435-42.
Jurado JL, Luna-Villegas G, Buela-Casal G. Normal human subjects with slow reaction times and larger time estimations after waking have diminished delta sleep. Electroencephalography and Clinical Neurophysiology 1989;73(2):124-8.
Spiegel R, Koberle S, Allen SR. Significance of slow wave sleep: considerations from a clinical viewpoint. Sleep 1986;9(1):66-79.
Born J, Rasch Br, Gais S. Sleep to remember. The Neuroscientist 2006;12(5):410-24.
Clemens Z, Fabo D, Halasz P. Overnight verbal memory retention correlates with the number of sleep spindles. Neuroscience 2005;132(2):529-35.
Van Dongen HP, Baynard MD, Maislin G, Dinges DF. Systematic interindividual differences in neurobehavioral impairment from sleep loss: evidence of trait-like differential vulnerability. Sleep 2004 May 1;27(3):423-33.
Mak SK, Spurgeon P. The effects of acute sleep deprivation on performance of medical residents in a regional hospital: prospective study. Hong Kong Medical Journal 2004;10(1):14-21.
Ardila A. Normal aging increases cognitive heterogeneity: Analysis of dispersion in WAIS-III scores across age. Archives of Clinical Neuropsychology 2007;22(8):1003-11.
Raz N, Gunning-Dixon FM, Head D, Dupuis JH, Acker JD. Neuroanatomical correlates of cognitive aging: evidence from structural magnetic resonance imaging. Neuropsychology 1998;12(1).
Gunning-Dixon FM, Raz N. The cognitive correlates of white matter abnormalities in normal aging: a quantitative review. Neuropsychology 2000;14(2):224-32.
Backman L, Ginovart N, Dixon RA, Wahlin TBR, Wahlin A, Halldin C, et al. Age-related cognitive deficits mediated by changes in the striatal dopamine system. American Journal of Psychiatry 2000;157(4):635-7.
The International Classification of Sleep Disorders, Fourth Edition (DSM-IV). American Academy of Sleep Medicine; European Sleep Research Society; Japanese Society of Sleep Research; Latin American Sleep Society; 1994.
Horne JA, Reyner LA. Sleep related vehicle accidents. BMJ 1995 Mar 4;310(6979):565-7.
Poudel GR, Innes CR, Bones PJ, Watts R, Jones RD. Losing the struggle to stay awake: Divergent thalamic and cortical activity during microsleeps. Hum Brain Mapp 2012 Sep 24;35(1):257-69.
Raichle ME, Mintun MA. Brain work and brain imaging. Annu Rev Neurosci 2006;29:449-76.
Guldenmund P, Vanhaudenhuyse A, Boly M, Laureys S, Soddu A. A default mode of brain function in altered states of consciousness. Arch Ital Biol 2012 Jun;150(2-3):107-21.
Mason MF, Norton MI, Van Horn JD, Wegner DM, Grafton ST, Macrae CN. Wandering minds: the default network and stimulus-independent thought. Science 2007 Jan 19;315(5810):393-5.
Raichle ME, MacLeod AM, Snyder AZ, Powers WJ, Gusnard DA, Shulman GL. A default mode of brain function. Proc Natl Acad Sci U S A 2001 Jan 16;98(2):676-82.
Picchioni D, Fukunaga M, Carr WS, Braun AR, Balkin TJ, Duyn JH, et al. fMRI differences between early and late stage-1 sleep. Neurosci Lett 2008 Aug 15;441(1):81-5.
Baird B, Smallwood J, Schooler JW. Back to the future: autobiographical planning and the functionality of mind-wandering. Conscious Cogn 2011 Dec;20(4):1604-11.
Fox KC, Nijeboer S, Solomonova E, Domhoff GW, Christoff K. Dreaming as mind wandering: evidence from functional neuroimaging and first-person content reports. Front Hum Neurosci 2013;7:412.
Dinges DF. An overview of sleepiness and accidents. Journal of Sleep Research 1995;4(s2):4-14.
Mitler MM, Carskadon MA, Czeisler CA, Dement WC, Dinges DF, Graeber RC. Catastrophes, sleep, and public policy: consensus report. Sleep 1988;11(1).
Ãkerstedt T, Czeisler CA, Dinges DF, Horne JA. Accidents and sleepiness: a consensus statement from the International Conference on Work Hours, Sleep and Accidents, Stockholm, 8-10 September 1994. J Sleep Res 1994;3.
Arendt J, Skene DJ. Melatonin as a chronobiotic. Sleep Med Rev 2005 Feb;9(1):25-39.
Luna TD. Air traffic controller shiftwork: what are the implications for aviation safety? A review. Aviation, Space, and Environmental Medicine 1997;68(1).
Morris TL, Miller JC. Electrooculographic and performance indices of fatigue during simulated flight. Biological Psychology 1996;42(3):343-60.
Hyman NH. Attending work hour restrictions: is it time? Archives of Surgery 2009;144(1).
Pickersgill T. The European Working Time Directive for doctors in training: we will need more doctors and better organisation to comply with the law. BMJ: British Medical Journal 2001;323(7324).
Ayas NT, Barger LK, Cade BE, Hashimoto DM, Rosner B, Cronin JW, et al. Extended work duration and the risk of self-reported percutaneous injuries in interns. JAMA: The Journal of the American Medical Association 2006 Sep 6;296(9):1055-62.
Fletcher KE, Underwood III W, Davis SQ, Mangrulkar RS, McMahon LF Jr, Saint S. Effects of work hour reduction on residents’ lives. JAMA: The Journal of the American Medical Association 2005;294(9):1088-100.
Pape HC, Pfeifer R. Restricted duty hours for surgeons and impact on residents quality of life, education, and patient care: a literature review. Patient Saf Surg 2009;3(1).
Reddy R, Guntupalli K, Alapat P, Surani S, Casturi L, Subramanian S. Sleepiness in medical ICU residents. Chest Journal 2009;135(1):81-5.