Key parameters of four selected catchment geo-systems (SEDIBUD Key Test Sites) in Eastern Iceland, Swedish Lapland and Finnish Lapland.
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Barely three months into the new year and we are happy to announce a monumental milestone reached - 150 million downloads.
\n\nThis achievement solidifies IntechOpen’s place as a pioneer in Open Access publishing and the home to some of the most relevant scientific research available through Open Access.
\n\nWe are so proud to have worked with so many bright minds throughout the years who have helped us spread knowledge through the power of Open Access and we look forward to continuing to support some of the greatest thinkers of our day.
\n\nThank you for making IntechOpen your place of learning, sharing, and discovery, and here’s to 150 million more!
\n\n\n\n\n'}],latestNews:[{slug:"intechopen-supports-asapbio-s-new-initiative-publish-your-reviews-20220729",title:"IntechOpen Supports ASAPbio’s New Initiative Publish Your Reviews"},{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"}]},book:{item:{type:"book",id:"7478",leadTitle:null,fullTitle:"Photocatalysts - Applications and Attributes",title:"Photocatalysts",subtitle:"Applications and Attributes",reviewType:"peer-reviewed",abstract:"This book enlightens the type, chemical structure, and application of photo-catalysts. It covers the recent developments in photo-catalysts and their applications, particularly in photo-catalytic degradation of different organic pollutants, hydrogen production, etc. It provides a concise but complete coverage and overview of photocatalysts and their recent advances for a broad audience: beginners, graduate students, and specialists in both academic and industrial sectors.",isbn:"978-1-78985-476-3",printIsbn:"978-1-78985-475-6",pdfIsbn:"978-1-83962-058-4",doi:"10.5772/intechopen.75848",price:119,priceEur:129,priceUsd:155,slug:"photocatalysts-applications-and-attributes",numberOfPages:156,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"26559479998a0a8d83546de0a220c87f",bookSignature:"Sher Bahadar Khan and Kalsoom Akhtar",publishedDate:"March 6th 2019",coverURL:"https://cdn.intechopen.com/books/images_new/7478.jpg",numberOfDownloads:14008,numberOfWosCitations:44,numberOfCrossrefCitations:45,numberOfCrossrefCitationsByBook:1,numberOfDimensionsCitations:104,numberOfDimensionsCitationsByBook:3,hasAltmetrics:1,numberOfTotalCitations:193,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"March 12th 2018",dateEndSecondStepPublish:"April 2nd 2018",dateEndThirdStepPublish:"June 1st 2018",dateEndFourthStepPublish:"August 20th 2018",dateEndFifthStepPublish:"October 19th 2018",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6,7",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"245468",title:"Dr.",name:"Sher Bahadar",middleName:null,surname:"Khan",slug:"sher-bahadar-khan",fullName:"Sher Bahadar Khan",profilePictureURL:"https://mts.intechopen.com/storage/users/245468/images/system/245468.jpg",biography:"Prof. Dr. Sher Bahadar Khan received his Ph.D from HEJ, Karachi University, Pakistan. After completion of his Ph.D, he started his post-doctoral career in nanochemistry and nanotechnology and continued to work as a post-doctoral research fellow to February 2010 at Yonsei University, South Korea. In March 2010, he joined the Center for Advanced Materials and Nano-engineering, Department of Chemistry, Najran University as an Assistant Professor and continued his work to 31 August 2011. He joined the Chemistry Department, King Abdulaziz University, Jeddah, Saudi Arabia as an Assistant Professor in September 2011. Currently he is Full Professor in the Chemistry Department, King Abdulaziz University and is doing research in nanochemistry and nanotechnology. He was honoured by receiving the top scientist award of KP Science & Technology in 2018. He was also honoured by the Deanship of Scientific Research awards at King Abdulaziz University for book, patent, and highly ranked scientific publication. He is the author of 320 research articles, twelve books, and six patents with almost 1000 ± 10 impact factor, 6665 citations, and 45 h-index.",institutionString:"King Abdulaziz University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"3",institution:{name:"King Abdulaziz University",institutionURL:null,country:{name:"Saudi Arabia"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:{id:"245469",title:"Dr.",name:"Kalsoom",middleName:null,surname:"Akhtar",slug:"kalsoom-akhtar",fullName:"Kalsoom Akhtar",profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:"Dr. Kalsoom Akhtar received her Ph.D from the Chemistry Department, Ewha Womans University, Seoul, Korea. Dr. K. Akhtar is an Assist. Professor in the Chemistry Department, King Abdulaziz University and is currently doing research in organic and nano-chemistry, which comprises photo-catalyst, organic synthesis, and metal oxide nanomaterials. She is the author of 2 books and 65 research papers.",institutionString:"King Abdulaziz University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"King Abdulaziz University",institutionURL:null,country:{name:"Saudi Arabia"}}},coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"509",title:"Photochemistry",slug:"photochemistry"}],chapters:[{id:"63788",title:"Disinfection Methods",doi:"10.5772/intechopen.80999",slug:"disinfection-methods",totalDownloads:3243,totalCrossrefCites:1,totalDimensionsCites:4,hasAltmetrics:0,abstract:"Water must be made safe to drink, and an important step in ensuring water safety is disinfection. Disinfectants are added to water to kill disease-causing microorganisms. Ground water sources can be disinfected by “The Water Treatment Rule,” which requires public water systems for disinfection. Chlorination, ozone, ultraviolet light, and chloramines are primary methods for disinfection. However, potassium permanganate, photocatalytic disinfection, nanofiltration, and chlorine dioxide can also be used. Organic material is naturally present in water. Certain forms of chlorine can react with these organic materials and result in the formation of harmful by-products; the U.S. Environmental Protection Agency has anticipated maximum levels for these contaminants.",signatures:"Muhammad Saqib Ishaq, Zobia Afsheen, Amjad Khan and Amjad\nKhan",downloadPdfUrl:"/chapter/pdf-download/63788",previewPdfUrl:"/chapter/pdf-preview/63788",authors:[{id:"228353",title:"Dr.",name:"Muhammad Saqib",surname:"Ishaq",slug:"muhammad-saqib-ishaq",fullName:"Muhammad Saqib Ishaq"},{id:"246559",title:"Dr.",name:"Zobia",surname:"Afsheen",slug:"zobia-afsheen",fullName:"Zobia Afsheen"},{id:"246561",title:"Mr.",name:"Amjad",surname:"Khan",slug:"amjad-khan",fullName:"Amjad Khan"},{id:"271289",title:"Dr.",name:"Amjad",surname:"Khan",slug:"amjad-khan",fullName:"Amjad Khan"}],corrections:null},{id:"63016",title:"Selective Photodegradation Using Titanate Nanostructures",doi:"10.5772/intechopen.80311",slug:"selective-photodegradation-using-titanate-nanostructures",totalDownloads:1022,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Adsorption and photocatalytic degradation are considered as the most important ways of treating water from organic compounds. It would be very useful if the adsorption and photocatalytic properties are combined in the same catalyst used in the treatment. Titania is one of the best well-known photocatalysts. However, due to its poor selectivity, it is unfavorable for photocatalytic removal of highly toxic low-level organic pollutants in wastewater in the presence of other less toxic high-level pollutants. Recent trials to introduce selectivity for titania have been achieved via controlling the catalyst morphology or by modifying the catalyst surface. This chapter summarizes the control of selectivity of titanate nanostructures toward adsorption and/or photocatalytic degradation of toxic organic dyes. In the first part, the effect of morphologies of titanites on selective photocatalytic degradation of three food dyes (color yellow sunset, red allura, and red carmoisine) was discussed. In changing the morphology of titanite, each dye is being preferably adsorbed by one morphology and decomposing more rapidly. In the second part, the selective adsorption and/or photocatalytic degradation of methylene blue dye from mixed dye solution using sodium titanate (NaTNT), cobalt-doped titanate nanotubes (co-doped TNT), and the decorated one with gold nanoparticles has been discussed.",signatures:"Ayman Hassan Zaki and Waleed Mohamed Ali. El Rouby",downloadPdfUrl:"/chapter/pdf-download/63016",previewPdfUrl:"/chapter/pdf-preview/63016",authors:[{id:"242465",title:"Dr.",name:"Ayman",surname:"Zaki",slug:"ayman-zaki",fullName:"Ayman Zaki"},{id:"261211",title:"Dr.",name:"Waleed",surname:"El Rouby",slug:"waleed-el-rouby",fullName:"Waleed El Rouby"}],corrections:null},{id:"62303",title:"Modified Titanium Dioxide for Photocatalytic Applications",doi:"10.5772/intechopen.79374",slug:"modified-titanium-dioxide-for-photocatalytic-applications",totalDownloads:4048,totalCrossrefCites:37,totalDimensionsCites:83,hasAltmetrics:1,abstract:"Titanium dioxide (TiO2) has been widely used as a photocatalyst in many environmental and energy applications due to its efficient photoactivity, high stability, low cost, and safety to the environment and humans. However, its large band gap energy, ca. 3.2 eV limits its absorption of solar radiation to the UV light range which accounts for only about 5% of the solar spectrum. Furthermore, the photocatalytic activity of TiO2 is also limited by the rapid recombination of the photogenerated electron-hole pairs. When used in water treatment applications, TiO2 has a poor affinity toward organic pollutants, especially hydrophobic organic pollutants. Several strategies have been employed to reduce its band gap energy, its electron-hole recombination rates as well as enhance its absorption of organic pollutants. In this chapter, we review some of the most recent works that have employed the doping, decoration, and structural modification of TiO2 particles for applications in photocatalysis. Additionally, we discuss the effectiveness of these dopants and/or modifiers in enhancing TiO2 photoactivity as well as some perspective on the future of TiO2 photocatalysis.",signatures:"John Moma and Jeffrey Baloyi",downloadPdfUrl:"/chapter/pdf-download/62303",previewPdfUrl:"/chapter/pdf-preview/62303",authors:[{id:"250026",title:"Dr.",name:"John",surname:"Moma",slug:"john-moma",fullName:"John Moma"},{id:"250963",title:"Mr.",name:"Jeffrey",surname:"Baloyi",slug:"jeffrey-baloyi",fullName:"Jeffrey Baloyi"}],corrections:null},{id:"64228",title:"Modified Metallic Oxides for Efficient Photocatalysis",doi:"10.5772/intechopen.80834",slug:"modified-metallic-oxides-for-efficient-photocatalysis",totalDownloads:1211,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:0,abstract:"The aim of the chapter is to present modified materials like alternatives for conventional photocatalyst such as titanium dioxide. Discussion about silver/graphene nanoparticles-modified zinc oxide for the degradation of pollutants like triclosan or bisphenol A, both considered as endocrine disruptors, which affect the hormonal development of humans, is presented. The best conditions to obtain the highest photodegradation degree are established. In addition, the bismuth oxychloride has gained attention during the last 5 years for photocatalysis. In accordance, the obtained results for phenol photodegradation, using such oxychloride, are also presented. In the chapter, the characterization of photocatalyst is reported along with the proposal for mechanisms of action for the modified ZnO photocatalyst and the bismuth oxychloride.",signatures:"Vladimir A. Escobar Barrios, Dalia Verónica Sánchez Rodríguez,\nNancy Ayerim Cervantes Rincón and Alma Berenice Jasso-Salcedo",downloadPdfUrl:"/chapter/pdf-download/64228",previewPdfUrl:"/chapter/pdf-preview/64228",authors:[{id:"12711",title:"Dr.",name:"Vladimir Alonso",surname:"Escobar Barrios",slug:"vladimir-alonso-escobar-barrios",fullName:"Vladimir Alonso Escobar Barrios"},{id:"252705",title:"MSc.",name:"Nancy",surname:"Cervantes-Rincón",slug:"nancy-cervantes-rincon",fullName:"Nancy Cervantes-Rincón"},{id:"252706",title:"Dr.",name:"Alma",surname:"Jasso-Salcedo",slug:"alma-jasso-salcedo",fullName:"Alma Jasso-Salcedo"},{id:"252707",title:"MSc.",name:"Dalia Verónica",surname:"Sánchez Rodríguez",slug:"dalia-veronica-sanchez-rodriguez",fullName:"Dalia Verónica Sánchez Rodríguez"}],corrections:null},{id:"63562",title:"Lanthanides Effects on TiO2 Photocatalysts",doi:"10.5772/intechopen.80906",slug:"lanthanides-effects-on-tio2-photocatalysts",totalDownloads:1138,totalCrossrefCites:2,totalDimensionsCites:4,hasAltmetrics:0,abstract:"Semiconductors have been evaluated to heterogeneous photocatalysis degradation of recalcitrant contaminants in aqueous media due to the capacity of mineralizing these compounds under UV or visible light irradiation. However, this process has the inherent feature of photogenerated charges recombination and the high bandgap energy of the electronic structure of some semiconductors that can reduce the formation of reactive oxygen species, which are responsible for the compound degradation. In this context, structural modifications in semiconductors have been proposed to enhance the photocatalytic activity, such as doping processes with elements that are capable of generating superficial defects that capture the formed electrons, avoiding the recombination, or increasing the density of –OH groups or water molecules on the surface of the catalyst, which can enhance the formation of hydroxyl radicals. Therefore, this brief review is proposed to show the role of lanthanides in the TiO2 doping and the synthesis method applied, as well as the results discussed in the literature.",signatures:"Gustavo Lopes Colpani, Micheli Zanetti, Rubieli Carla Frezza\nZeferino, Luciano Luiz Silva, Josiane Maria Muneron de Mello,\nHumberto Gracher Riella, Natan Padoin, Márcio Antônio Fiori and\nCíntia Soares",downloadPdfUrl:"/chapter/pdf-download/63562",previewPdfUrl:"/chapter/pdf-preview/63562",authors:[{id:"215607",title:"Dr.",name:"Josiane",surname:"Mello",slug:"josiane-mello",fullName:"Josiane Mello"},{id:"257258",title:"Dr.",name:"Gustavo",surname:"Colpani",slug:"gustavo-colpani",fullName:"Gustavo Colpani"},{id:"257927",title:"MSc.",name:"Micheli",surname:"Zanetti",slug:"micheli-zanetti",fullName:"Micheli Zanetti"},{id:"257928",title:"MSc.",name:"Rubieli Carla Frezza",surname:"Zeferino",slug:"rubieli-carla-frezza-zeferino",fullName:"Rubieli Carla Frezza Zeferino"},{id:"257929",title:"Dr.",name:"Luciano Luiz",surname:"Silva",slug:"luciano-luiz-silva",fullName:"Luciano Luiz Silva"},{id:"268440",title:"Dr.",name:"Cíntia",surname:"Soares",slug:"cintia-soares",fullName:"Cíntia Soares"},{id:"268441",title:"Dr.",name:"Natan",surname:"Padoin",slug:"natan-padoin",fullName:"Natan Padoin"},{id:"268442",title:"Dr.",name:"Humberto",surname:"Gracher Riella",slug:"humberto-gracher-riella",fullName:"Humberto Gracher Riella"},{id:"268443",title:"Dr.",name:"Márcio",surname:"Fiori",slug:"marcio-fiori",fullName:"Márcio Fiori"}],corrections:null},{id:"63323",title:"Carbon-/Zeolite-Supported TiO2 for Sorption/Photocatalysis Applications in Water Treatment",doi:"10.5772/intechopen.80803",slug:"carbon-zeolite-supported-tio2-for-sorption-photocatalysis-applications-in-water-treatment",totalDownloads:973,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"The role of various carbon forms, i.e., activated carbon and carbon nanotubes/nanofibers as support for TiO2 in drinking water treatment, is discussed. Also, TiO2 supported onto zeolite that acts bifunctionally as a sorbent/photocatalyst for drinking water treatment is presented. The main contaminants of natural organic matter (NOM), arsenic species, and nitrogen compounds from drinking water sources by the type of groundwater and surface water can be removed/degraded by sorption/photocatalysis using TiO2 supported onto carbon and/or zeolite. TiO2 supported on powdered activated carbon (PAC-TiO2), granular activated carbon (GAC-TiO2), and zeolite (Z-TiO2), namely, supported TiO2, was synthesized through the sol-gel method, and TiO2 and multiwall carbon nanotubes/carbon nanofibers dispersed within epoxy matrix (CNT-TiO2-Epoxy, CNF-TiO2-Epoxy), namely, TiO2 composite, were obtained through the two-roll mill method. Kinetic study results through specific mathematic models allowed to elucidate some mechanistic aspects for sorption and photocatalysis for the application in drinking water. The intercalation of the carbon- and zeolite-supported TiO2 layers into a filtering system allows to develop a self-cleaning filtering system in drinking water.",signatures:"Florica Manea and Corina Orha",downloadPdfUrl:"/chapter/pdf-download/63323",previewPdfUrl:"/chapter/pdf-preview/63323",authors:[{id:"249975",title:"Prof.",name:"Florica",surname:"Manea",slug:"florica-manea",fullName:"Florica Manea"},{id:"251672",title:"Dr.",name:"Corina",surname:"Orha",slug:"corina-orha",fullName:"Corina Orha"}],corrections:null},{id:"63802",title:"Evaluation of the Role of Hydroxyapatite in TiO2/ Hydroxyapatite Photocatalytic Materials",doi:"10.5772/intechopen.81092",slug:"evaluation-of-the-role-of-hydroxyapatite-in-tio2-hydroxyapatite-photocatalytic-materials",totalDownloads:1140,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"The TiO2/hydroxyapatite (HAp) composite has attracted much attention as a photocatalyst for pollution treatment in water or air because this composite can improve the properties of pure TiO2 including a low efficiency, narrow light response range, low adsorption capacity for hydrophobic contaminants, and difficult recovery of TiO2 particles after using in Aquarius environment. To obtain the best composite containing the two components including TiO2 and HAp, the role of HAp in TiO2/hydroxyapatite photocatalytic material should be analyzed and evaluated. This chapter will significantly present a review of the role of HAp in the TiO2/hydroxyapatite composite including the adsorption ability of contaminations and the promoted impacts of HAp component.",signatures:"Linh Nguyen Thi Truc, Seungbum Hong and Kwangsoo No",downloadPdfUrl:"/chapter/pdf-download/63802",previewPdfUrl:"/chapter/pdf-preview/63802",authors:[{id:"240618",title:"Prof.",name:"Seungbum",surname:"Hong",slug:"seungbum-hong",fullName:"Seungbum Hong"},{id:"250784",title:"Dr.",name:"Linh",surname:"Nguyen",slug:"linh-nguyen",fullName:"Linh Nguyen"},{id:"252169",title:"Prof.",name:"Kwangsoo",surname:"No",slug:"kwangsoo-no",fullName:"Kwangsoo No"}],corrections:null},{id:"63673",title:"Photoreduction Processes over TiO2 Photocatalyst",doi:"10.5772/intechopen.80914",slug:"photoreduction-processes-over-tio2-photocatalyst",totalDownloads:1235,totalCrossrefCites:3,totalDimensionsCites:8,hasAltmetrics:0,abstract:"This chapter presents the study of TiO2 photocatalyst for the photoreduction of several reducible chemicals. The photocatalytic reduction of several toxic metal ions, including Ag(I), Cu(II), Cr(VI), Hg(II), and U(VI) in the presence of TiO2, in order to decrease their toxicity, is described. Photodeposition of the noble metals, such as Ag(I), Au(III), Pt(IV), and Pd(II) for doping purposes by photocatalytic reduction over TiO2, is also addressed. Conversion of the greenhouse gas of CO2 into useful hydrocarbons and methanol by photocatalytic reduction using TiO2 photocatalyst is highlighted. Several operating parameters in photoreduction processes that are photocatalyst dose, time of the irradiation, pH of the solution, and the initial concentration of the substrates (the reducible chemicals) are also reviewed.",signatures:"Endang Tri Wahyuni and Nurul Hidayat Aprilita",downloadPdfUrl:"/chapter/pdf-download/63673",previewPdfUrl:"/chapter/pdf-preview/63673",authors:[{id:"225211",title:"Prof.",name:"Endang Tri",surname:"Wahyuni",slug:"endang-tri-wahyuni",fullName:"Endang Tri Wahyuni"},{id:"267675",title:"Dr.",name:"Nurul Hidayat",surname:"Aprilita",slug:"nurul-hidayat-aprilita",fullName:"Nurul Hidayat Aprilita"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"7358",title:"Cerium Oxide",subtitle:"Applications and Attributes",isOpenForSubmission:!1,hash:"7d1cd9a9ecf46270e344d15f94bc66ef",slug:"cerium-oxide-applications-and-attributes",bookSignature:"Sher Bahadar Khan and Kalsoom Akhtar",coverURL:"https://cdn.intechopen.com/books/images_new/7358.jpg",editedByType:"Edited by",editors:[{id:"245468",title:"Dr.",name:"Sher Bahadar",surname:"Khan",slug:"sher-bahadar-khan",fullName:"Sher Bahadar Khan"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8724",title:"Gas Sensors",subtitle:null,isOpenForSubmission:!1,hash:"bc4be4b954b559709aaace45f70adcd0",slug:"gas-sensors",bookSignature:"Sher Bahadar Khan, Abdullah M. 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Research on sedimentary fluxes from source to sink in a variety of different climatic environments is represented by a substantial body of literature. Studies on source-to-sink fluxes generally refer to the development of sediment budgets. A sediment budget is an accounting of the sources and disposition of sediment as it travels from its point of origin to its eventual exit from a defined landscape unit like a drainage basin, e.g. [1]. Accordingly, the development of a sediment budget necessitates the identification of processes of erosion, transport and deposition within a defined area, and their rates and controls [1, 2, 3]. The fundamental concept underpinning source-to-sink sediment flux and sediment budget studies is the basic sediment mass balance equation:
Where inputs (I) equal outputs (O) plus changes in net storage of sediment (ΔS). Source-to-sink studies permit quantification of the transport and storage of sediment in a system. A thorough understanding of the current sediment production and flux regime within a system is fundamental to predict likely effects of changes to the system, whether climatic induced or human-influenced. Source-to-sink sediment flux and sediment budget research therefore enables the prediction of changes to erosion and sedimentation rates, knowledge of where sediment will be deposited, how long it will be stored and how much sediment will be remobilised [1, 3, 4].
Sediments are eroded and mobilised in source areas. Sediment sources are diverse and subject to variation in response to climate change. Global warming leads to the loss of glacial ice, which in turn increases slope instability caused by glacial de-buttressing, and flooding from glacial and moraine-dammed lakes [5, 6]. All these processes redistribute sediments and operate at different rates as a result of change to the system. Glaciers and ice sheets exert strong controls on the supply of sediments. For example, Knight et al. [7] identify the basal ice layer of a section of the Greenland ice sheet as the dominant source of sediment production. There is, however, only limited knowledge of debris fluxes from ice sheets and glaciers and its variability. The main mechanisms of sediment production in source areas can be described in terms of contemporary environmental conditions. However, in order to fully understand sediment supply a longer-term perspective is needed. Over the Quaternary, glacier fluctuations have had profound influences in depositing extensive mantles of sediments. More-widely, periglacial activity has altered the landscape under non-glacial cold climate conditions. The obvious imprint of this legacy is often reflected in contemporary sediment transfer rates where pre-existing deposits are eroded by present-day processes [6, 8].
Sediment transfers move eroded sediments from their source area to an area of temporal storage or long-term deposition in sinks. Rates of sediment transfer are not only conditioned by competence of geomorphic processes but also by the availability of sediment for transport. Accordingly, in assessing sediment transfer we need to quantify the forces, which drive transport processes but equally account for the factors, which control sediment supply [8]. Glacial fluxes are arguably the most significant processes for contemporary sediment flux [9]. Small-scale process studies very often focus on sedimentary fluxes from areas of weathering and erosion to areas of storage within defined landscape units like drainage basins, whereas large-scale sediment systems couple headwaters to oceanic sinks. For example, Gordeev [10], applying models developed by Morehead et al. [11], estimates the increase in sediment load in Arctic rivers in response to a rise in surface temperature of the drainage basins. Based on this model, increases in river discharge lead to an increase in the sediment flux of the six largest Arctic rivers, predicted to range from 30% to 122% by the year 2100.
The identification of storage elements and sinks is critical to the effective study and understanding of source-to-sink sedimentary fluxes [1]. The setting of a particular drainage basin defines the boundary conditions for storage within that landscape unit. Within a defined landscape unit like a drainage basin, the slope and valley infill elements constitute the key storage units and storage volumes are important for addressing time-dependent sediment budget dynamics. Dating of storage in sedimentary source-to-sink flux studies is applied to determine or estimate the ages and chronology of the storage components within the system. An understanding of the nature of primary stores, secondary stores and the potential storage capacities of different types of drainage basins is important along with knowledge of sediment residence times. Of growing importance is the development of innovative field methods, such as geophysical techniques for estimating sediment storage volumes [12, 13, 14]. Within large-scale sediment systems oceanic sinks are most important and provide the opportunity to estimate rates of sediment production and delivery at long-term temporal as well as continental spatial scales [15, 16].
Amplified climate change and ecological sensitivity of polar and cold environments has been highlighted as a key global environmental issue [17]. Projected climate change in cold regions is expected to alter melt season duration and intensity, along with the number of extreme rainfall events, total annual precipitation and the balance between snowfall and rainfall. Similarly, changes to the thermal balance are expected to reduce the extent of permafrost and seasonal ground frost and increase active layer and thaw depths. These effects will undoubtedly change surface environments in cold environments and alter the fluxes of sediments, nutrients and solutes, but the absence of data and analysis to understand the sensitivity of the surface environment are acute in cold climate environments.
The
Achim A. Beylich (
Armelle Decaulne (
John C. Dixon (USA)
Scott F. Lamoureux (
John F. Orwin (Canada)
Jan-Christoph Otto (Austria)
Irina Overeem (USA)
Þorsteinn Sæmundsson (Iceland)
Jeff Warburton (UK)
Zbigniew Zwolinski (Poland)
The central research question of this global group of scientists is to
Initially formed as European Science Foundation (ESF) Network SEDIFLUX (2004-2006) [20, 21], SEDIBUD has further expanded to a global group of researchers with in total 44 field research sites (SEDIBUD Key Test Sites) located in polar and alpine regions in the northern and southern hemisphere, see [22]. Research carried out at each site varies by programme, logistics and available resources, but typically represents interdisciplinary collaborations of geomorphologists, hydrologists, ecologists, permafrost scientists and glaciologists. SEDIBUD has developed a key set of primary surface process monitoring and research data requirements to incorporate results from these diverse projects and allow coordinated quantitative analysis across the programme. SEDIBUD Key Test Sites provide data on annual climate conditions, total discharge and particulate and dissolved fluxes as well as information on other relevant surface processes. A number of selected SEDIBUD Key Test Sites is providing high-resolution data on climate conditions, runoff and sedimentary fluxes, which in addition to the annual data contribute to the SEDIBUD Metadata Database which is currently developed. To support these coordinated efforts, the SEDIFLUX Manual [3] has been produced to establish common methods and data standards [18, 19]. In addition, a framework paper for characterizing fluvial sediment fluxes from source to sink in cold environments has been published by the group [23].
Comparable datasets from different SEDIBUD Key Test Sites are analysed to address key research questions of the SEDIBUD Programme as defined in the SEDIBUD Working Group Objective [24].
Table 1 compiles key parameters of four selected SEDIBUD research field sites (Figures 1 and 2) as examples.
\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t\t\n\t\t\t\t | \n\t\t|||
Hrafndalur (Iceland) | \n\t\t\t65º28`N, 13º42`W | \n\t\t\t7 | \n\t\t\t6 – 731; 725 | \n\t\t\t3.6 | \n\t\t\t1719 | \n\t\t\tRhyolites | \n\t\t
Austdalur (Iceland) | \n\t\t\t65º16`N, 13º48`W | \n\t\t\t23 | \n\t\t\t0 – 1028; 1028 | \n\t\t\t3.6 | \n\t\t\t1431 | \n\t\t\tBasalt | \n\t\t
Latnjavagge (Sweden) | \n\t\t\t68º20`N, 18º30E | \n\t\t\t9 | \n\t\t\t950 – 1440; 490 | \n\t\t\t-2.0 | \n\t\t\t852 | \n\t\t\tMica-garnet schists | \n\t\t
Kidisjoki (Finland) | \n\t\t\t69º47`N, 27º05`E | \n\t\t\t18 | \n\t\t\t75 – 365; 290 | \n\t\t\t-2.0 | \n\t\t\t415 | \n\t\t\tGneisses and granulites | \n\t\t
Key parameters of four selected catchment geo-systems (SEDIBUD Key Test Sites) in Eastern Iceland, Swedish Lapland and Finnish Lapland.
Location of the four selected SEDIBUD Key Test Sites Hrafndalur (Iceland), Austdalur (Iceland), Latnjavagge (Sweden) and Kidisjoki (Finland)
Views of the four selected SEDIBUD Key Test Sites Hrafndalur (Eastern Iceland), Austdalur (Eastern Iceland), Latnjavagge (Swedish Lapland) and Kidisjoki (Finnish Lapland)
The generation and compilation of directly comparable data sets from the defined SEDIBUD Key Test Sites in the SEDIBUD Metadata Database is the basis for modelling effects of climate change on sedimentary fluxes and yields in cold climate environments by using space-for-time substitution [3, 18-21].
Annual data (as required from defined SEDIBUD Key Test Sites) from the four examples Hrafndalur (Iceland) [25, 26, 27], Austdalur (Iceland) [26, 27], Latnjavagge (Sweden) [25, 26, 28] and Kidisjoki (Finland) [25, 26] are compiled in Table 2. Time series of these mean annual data are published in [25-28].
Mean annual temperature (ºC): | \n\t\t\t3.6 | \n\t\t
Total annual precipitation [mm]: | \n\t\t\t1719 | \n\t\t
Total annual runoff [mm]: | \n\t\t\t1344 | \n\t\t
Annual suspended sediment yield [t km-2]: | \n\t\t\t19 | \n\t\t
Annual solute yield (atmospherically corrected) [t km-2]: | \n\t\t\t29 | \n\t\t
Mean annual temperature (ºC): | \n\t\t\t3.6 | \n\t\t
Total annual precipitation [mm]: | \n\t\t\t1431 | \n\t\t
Total annual runoff [mm]: | \n\t\t\t1130 | \n\t\t
Annual suspended sediment yield [t km-2]: | \n\t\t\t42 | \n\t\t
Annual solute yield (atmospherically corrected) [t km-2]: | \n\t\t\t8 | \n\t\t
Mean annual temperature (ºC): | \n\t\t\t-2.0 | \n\t\t
Total annual precipitation [mm]: | \n\t\t\t852 | \n\t\t
Total annual runoff [mm]: | \n\t\t\t717 | \n\t\t
Annual suspended sediment yield [t km-2]: | \n\t\t\t2.4 | \n\t\t
Annual solute yield (atmospherically corrected) [t km-2]: | \n\t\t\t4.9 | \n\t\t
Mean annual temperature (ºC): | \n\t\t\t-2.0 | \n\t\t
Total annual precipitation [mm]: | \n\t\t\t415 | \n\t\t
Total annual runoff [mm]: | \n\t\t\t324 | \n\t\t
Annual suspended sediment yield [t km-2]: | \n\t\t\t0.3 | \n\t\t
Annual solute yield (atmospherically corrected) [t km-2]: | \n\t\t\t3.1 | \n\t\t
Compiled annual data from four selected SEDIBUD Key Test Sites
On the basis of geomorphic process rates which were calculated for the Hrafndalur, Austdalur, Latnjavagge and Kidisjoki drainage basins after longer-term field studies (several years of process monitoring, mapping and observation) [26], the absolute and the relative importance of present-day denudative surface processes in the entire catchments was estimated by the quantification of the mass transfers caused by the different denudative surface processes. To allow direct comparison of the different denudative processes, all mass transfers are shown as tonnes multiplied by meter per year (t m yr-1), i.e. as the product of the annually transferred mass and the corresponding transport distance, see [26, 29-31].
As based on these quantitative investigations, in all selected study areas in sub-Arctic oceanic eastern Iceland, Arctic oceanic Swedish Lapland and sub-Arctic oceanic Finnish Lapland the intensity of contemporary denudative surface processes and mass transfers caused by these geomorphic processes is altogether rather low.
A direct comparison of the annual mass transfers within the four investigated drainage basins (Figure 3) summarises that there are differences between process intensities and the relative importance of different denudative processes within the study areas in Eastern Iceland, Swedish Lapland and Finnish Lapland.
The major controls of the detected differences are (see Figure 3):
The higher annual precipitation along with the larger number of extreme rainfall events and the higher frequency of snowmelt and rainfall generated peak runoff events in eastern Iceland as compared to Swedish Lapland and Finnish Lapland leads to higher mass transfers (Figure 3). All four study areas are located in oceanic cold regions and projected climate change is expected to alter melt season duration and intensity, along with an increased number of extreme rainfall events, total annual precipitation and the balance between snowfall and rainfall. In addition, changes in the thermal balance are expected to reduce the extent of permafrost and seasonal ground frost and increase active layer depths [17]. Looking at the existing differences between Hrafndalur / Austdalur (eastern Iceland), Latnjavagge (Swedish Lapland) and Kidisjoki (Finnish Lapland) it seems obvious that the projected changes in climate will cause significant changes of mass transfers.
Statistical correlations between topographic relief and annual precipitation and annual mass transfers by slope processes and fluvial transport (fluvial solute transport, fluvial suspended sediment transport, fluvial bedload transport) for the four selected SEDIBUD Key Test Sites Hrafndalur (H), Austdalur (A), Latnjavagge (L) and Kidisjoki (K)
The greater steepness of the Icelandic drainage basins leads to larger mass transfers here as compared to Latnjavagge and especially to Kidisjoki (Figure 3).
The low resistance of the rhyolites in Hrafndalur causes especially high weathering rates and connected mass transfers in this drainage basin (see Figure 3). Due to the lower resistance of the rhyolites as compared to the basalts found in Austdalur Postglacial modification of the glacially formed relief is clearly further advanced in Hrafndalur as compared to Austdalur.
The significant disturbance of the vegetation cover by direct human impacts in Hrafndalur / Austdalur (eastern Iceland) causes higher mass transfers by slope wash here whereas restricted sediment availability is a major reason for lower mass transfers in Latnjavagge (Swedish Lapland) and Kidisjoki (Finnish Lapland).
As a result, hydro-climate and topographic relief, followed by lithology and vegetation cover (with vegetation cover being partly modified by human activity), are the main controls of the mass transfers modifying the investigated sub-Arctic / Arctic landscapes, see also [32]. More studies to the present one, carried out within the SEDIBUD Programme with unified geomorphologic field methods [3, 21, 33, 34] in environments having different climatic, vegetation, human impact, topographic, lithological / geological and/or tectonic features will help to gain improved understanding of the internal differentiation of different global cold climate environments, see e.g. [21, 33, 35, 36]. Furthermore, additional information on the control mechanisms of processes, the role of extreme geomorphic events for longer-term mass transfers and sediment budgets, the general intensity of geomorphic processes and mass transfers, and the relative importance of different processes for slope and valley formation and relief development under different environmental conditions can be collected. Direct comparisons of SEDIBUD Key Test Sites (catchment geo-systems) and the application of the Ergodic principle of space-for-time substitution will improve the possibilities to model relief development as well as possible effects of projected climate change in cold climate environments.
In addition to achieving the energy conversion, wind energy heating system can also get the thermal energy needed by users through the “wind energy-mechanical energy-thermal energy” route [1]. The kinetic energy of the natural wind is captured and converted to mechanical energy by the wind turbine firstly, and then the heater converts the mechanical energy to the desired thermal energy. Compared with the first type of energy conversion, the second form is called the wind energy direct heating system and it saves the power generation equipment (as shown in Figure 1) and reduces the number of energy conversion time. The system will further reduce the initial investment cost and significantly improve the energy utilization coefficient.
Schematic diagram of the “wind energy-mechanical energy-thermal energy” conversion pathway.
The vertical axis wind turbine has attracted more and more attention due to its simple structure, low cost, and no yaw system required. The vertical axis wind turbine is divided into lift-type and drag-type vertical axis wind turbines, between which the lift-type one has a higher wind energy utilization coefficient under the high blade tip speed ratio, and thus the wind turbine has higher power. Lift-type vertical axis wind turbines are usually designed with two-or three-bladed wind turbines, and the three-bladed turbine has a lower shaft torque ripple and better self-starting characteristics compared to the two-bladed turbine [2].
The basic principle of the permanent magnet eddy current heater (Figure 2) is that when the rotor of the eddy current heater starts to rotate, the stator heating element is in the changing magnetic field. Since the stator heating element is generally a solid metal structure, many free loops can be formed inside it. Under the action of changing magnetic field, the magnetic flux of each circuit will change, which will produce an induced current. The impedance value formed in the stator heating body is small, so the circuit current will be large, so as to achieve the effect of heating.
Model of the permanent magnet eddy current heater.
For the study of wind energy heating, the authors in reference [3] set up an outdoor mixing heating experimental platform powered by natural wind and calculated the heating efficiency by the recorded wind speed, rotational speed, and temperature of working fluid. The authors in reference [4] compared the heating effects of the flat blade and the cylindrical blade and found that the heating effect of the flat blade is much better. The authors in reference [5] established a mathematical model to match the torque and the power, which provides a theoretical basis for the design of the stirred wind heating device. The authors in reference [6] optimized the structure of the wind turbine by using the Fluent software according to the relevant theory of wind turbine. The authors in reference [7] used Computational Fluid Dynamics (CFD) method to analyze the thermal efficiency of wind energy heating, and verified the feasibility of using CFD to analyze the mixing heating device.
The basic principle of the liquid stirring heater (Figure 3) is that the wind turbine directly drives the agitator to rotate the liquid at high speed and make the liquid heat.
Model of liquid stirring heater.
The authors in reference [8] studied the relationship between the torque required in the starting stage of the liquid stirring heater and the stirring impeller radius, angular acceleration. The liquid stirring heater is accompanied by a higher torque when starting.
The authors in reference [9] studied the permanent magnet eddy current heater directly driven by the vertical axis resistance differential wind turbine and analyzed the work of the permanent magnet eddy current heater under a certain wind speed. The authors in reference [10] simulated the permanent magnet eddy current heater model using the finite element method, determined the relevant geometric parameters and material properties of the model and obtained the heater power. The authors in reference [11] set up a permanent magnet eddy current heater experiment device, through which the relevant data were obtained. By using the test device, the temperature changes under different rotating speeds, working times, and different import and export water temperatures were measured, and then the corresponding conversion efficiency was obtained. The authors in reference [12] show that the increase of the thermal energy of the permanent magnet eddy current heater is roughly proportional to the square of the rotational speed increase. The authors in reference [13] pointed out that for the instability and intermittent nature of wind energy, connecting the thermal energy storage device after the permanent magnet eddy current heater can ensure the stable output of thermal energy.
In this study, the operation characteristics of the heater directly driven by a vertical axis wind turbine (Figure 4) under different working conditions are studied. The heating efficiencies of the two types of heaters are analyzed, and the matching relationship between the wind turbine and heater is optimized (see Figures 2–4).
Model of vertical axis wind turbine in wind tunnel test.
The wind turbine model is a three-blade vertical axis wind turbine adopting the NACA0018 symmetrical airfoil. The string length (
Geometric model of vertical axis wind turbine.
The parameter name | Value | Unit |
---|---|---|
Blade height/ | 1 | m |
Airfoil | NACA0018 | — |
Chord length/ | 0.25 | m |
Blade number | 3 | — |
Rotor rotating diameter/ | 1.1 | m |
Dimension parameters of the vertical axis wind turbine.
Schematic diagram of the 3D Computational domain.
The aerodynamic characteristics of the vertical axis wind turbine can be expressed as follows:
The following speed relation is satisfied when the wind turbine blades are in each position as Eq. (1):
where,
The force analysis of a certain determined blade is shown in Figure 7. The central point of the vertical axis wind turbine is the
Force analysis of the element on the blade.
The other component can be expressed as Eq. (3):
So, the force on the blade is expressed as Eq. (4):
Based on the above velocity decomposition relationship, the attack angle of blade is as Eq. (5):
The aerodynamic pressure acting on the blade can be expressed as Eq. (6):
The Lilienthal aerodynamic coefficient at this blade element is expressed as Eq. (7):
where
Component forces of normal direction and wing string direction of the blade are given as Eq. (8):
Decompose the above component forces to the flow wind speed direction, the resultant force received by the rotor in that direction is as Eq. (9):
where
The torque formula provided by the force acting on the blade for the rotor rotation axis is expressed as Eq. (10):
Integrating the above formulas, the torque of the whole rotor is expressed as Eq. (11):
Therefore, the power is expressed as Eq. (12):
The wind energy utilization coefficient
Grid division is a very important part in numerical simulation. Good grid division can improve the accuracy of the wind turbine performance prediction. In order to ensure the accuracy of the simulation, this study adopts the 3D structured grid for the wind turbine as shown in Figure 8.
Mesh of vertical axis wind turbine: (a) top view of mesh in rotating domain; (b) mesh around blade; (c) the entire mesh in the computational domain.
For the three-blade wind turbine model studied in this paper, the pressure-velocity coupling method and SIMPLE algorithm are used to solve the transient URANS Equation, and the pressure order, momentum term, and turbulence dissipation term are all solved by the second-order windward space dissipation algorithm, and the judgment criterion of convergence is set to 10−5. The turbulence model used in the simulation is the transition
Comparison of 3D numerical simulation results to experimental data and 2D numerical simulation results.
It is known from experiments that when the working fluid temperature of the bulk heat exchange surface increases by 60°C under different speed conditions, the faster the speed of the permanent magnet eddy current heater, the faster the working fluid temperature of the heat exchanger surface increases. However, if the speed is too fast, it will lead to an increase in heat production absorbed by the bulk metal during the heater operation, the uniform heating of circulating working fluid, and a high energy loss. Overall, the running speed of the heater is relatively suitable at 20 rad/s. The starting torque of the permanent magnet eddy current heater is about 6.89N·m, while after the magnetic eddy current heater is used as the wind turbine load, the wind turbine tip speed is relatively low, which will deviate from the optimal tip speed ratio interval, and thus leads to a low wind energy utilization coefficient during operation.
For the permanent magnet eddy current heater, when the wind speed varies from 13 m/s to 17 m/s, the output parameters of the wind turbine are shown in Table 2.
Wind speed/(m/s) | Rotating speed/(rad/s) | Tip speed ratio | CP | Torque/(N m) | Power of wind turbine/(W) |
---|---|---|---|---|---|
13.0 | 5.76 | 0.24 | 0.027 | 7.01 | 40.39 |
13.5 | 6.80 | 0.27 | 0.033 | 8.09 | 55.09 |
14.0 | 8.37 | 0.33 | 0.044 | 9.61 | 80.54 |
14.5 | 9.94 | 0.38 | 0.045 | 11.33 | 112.78 |
15.0 | 11.51 | 0.42 | 0.067 | 13.23 | 152.45 |
15.5 | 13.08 | 0.46 | 0.080 | 15.24 | 199.60 |
16.0 | 15.70 | 0.59 | 0.127 | 16.70 | 350.34 |
16.5 | 17.79 | 0.60 | 0.128 | 21.54 | 383.52 |
17.0 | 19.89 | 0.64 | 0.150 | 24.89 | 495.21 |
Output parameters of wind turbine at 13–17 m/s wind speeds.
The rotating speed and torque curve of wind turbine under different wind speed conditions are shown in Figures 10 and 11. Clearly, the rotating speed and torque of the wind turbine both increase linearly with the wind speed increased.
Curve of the rotating speed change at 13–17 m/s wind speeds.
Curve of the torque change at 13–17 m/s wind speeds.
According to the experimental data, the relationship between the heat absorption power
The relationship between the power of heat absorption
Therefore, the efficiency of the heater can be expressed as Eq. (16):
where
The system efficiency is the ratio of the heat obtained by the circulating working fluid to the wind energy swept by the wind turbine. It can directly reflect how much energy the heating system captures from the natural wind. The expression is Eq. (17):
According to the above formulas, the heating efficiency and system efficiency of the permanent magnet eddy current heater can be obtained (Table 3) by using the output power of the wind turbine.
Wind speed/(m/s) | Power of wind turbine/(W) | Thermal energy exchange power/(W) | Heating efficiency/(%) | System efficiency/(%) |
---|---|---|---|---|
13.0 | 40.39 | 17.11 | 42.36 | 1.14 |
13.5 | 55.09 | 22.94 | 41.64 | 1.37 |
14.0 | 80.54 | 33.85 | 42.02 | 1.85 |
14.5 | 112.78 | 49.15 | 43.58 | 1.96 |
15.0 | 152.45 | 70.27 | 46.09 | 3.09 |
15.5 | 199.60 | 98.64 | 49.42 | 3.95 |
16.0 | 350.34 | 213.21 | 60.68 | 7.73 |
16.5 | 383.52 | 243.31 | 63.44 | 8.12 |
17.0 | 495.21 | 357.58 | 72.21 | 10.83 |
The heating efficiency and system efficiency of the permanent magnet eddy current heater.
As seen from Figures 12 and 13, with the increase of the test wind speed, the heating efficiency increases at the same time. The heating efficiency and system efficiency are significantly increased when the wind speed is higher than 15.5 m/s. When the wind speed is 17 m/s, the heating efficiency and system efficiency reach the maximum values of 72.21% and 10.83%, respectively. Hence, the permanent magnet eddy current heater has higher efficiency under the condition of higher wind speed and rotating speed.
Curve of the heating efficiency change at 13–17 m/s wind speeds.
Curve of the system efficiency change at 13–17 m/s wind speeds.
According to the experiment results, the temperature rise rate fluctuates in a certain range when the liquid stirring heater rotates at different speeds, but it does not attenuate with the increase of the working fluid temperature. Hence, with the rise of work fluid temperature, the increase of environmental thermal dissipation will not significantly affect the working fluid temperature rise rate. The changes in working fluid temperature at different heater speeds are in linear function, and the effect of heater speed on heating is significant. The strength and stiffness of mixing blade and the plate under high speed are also need to be considered.
The wind turbine can complete the start-up operation at a low wind speed, and the starting torque is much lower than the permanent magnet eddy current heater at the same power level. Therefore, compared with the permanent magnet eddy current heater, the mixing heater can use the wind energy at a lower speed and improve the wind energy utilization. Due to the small drive torque of the stirring heater, the wind turbine speed is increased, the tip speed ratio is close to the optimal tip speed ratio with a higher wind energy utilization coefficient.
When the wind speed varies from 7 m/s to 13 m/s, the output parameters are given in Table 4.
Wind speed/(m/s) | Rotating speed/(rad/s) | Tip speed ratio | CP | Torque/(N m) | Power of wind turbine/(W) |
---|---|---|---|---|---|
7.0 | 13.61 | 1.07 | 0.202 | 3.62 | 49.30 |
8.0 | 18.84 | 1.29 | 0.264 | 5.10 | 96.17 |
9.0 | 21.98 | 1.34 | 0.281 | 6.63 | 145.75 |
10.0 | 26.17 | 1.43 | 0.292 | 7.94 | 207.76 |
11.0 | 29.30 | 1.46 | 0.295 | 9.53 | 279.37 |
12.0 | 32.44 | 1.49 | 0.297 | 11.26 | 365.15 |
13.0 | 35.59 | 1.51 | 0.295 | 12.96 | 461.13 |
Output parameters of wind turbine at 7–13 m/s wind speeds.
The rotating speed and torque curve of the wind turbine in the test wind speed interval are shown in Figures 14 and 15. It can be seen that the rotating speed and torque both change linearly in the test wind speed range. Therefore, when the rotating speed of the heater increases, the mixing resistance is borne by the blade and the flow resistance plate will also increase simultaneously. When the heater power is necessary to be further improved, the design of the mixing blade and the damping plate structure should be optimized to increase the mixing resistance and reduce the maximum rotating speed.
Curve of the rotating speed change at 7–13 m/s wind speeds.
Curve of the torque change at 7–13 m/s wind speeds.
Based on Eqs. (15)–(17), the heating efficiency and system efficiency (Table 5) of the liquid stirring heater can be obtained according to the output power of the wind turbine.
Wind speed/(m/s) | Power of wind turbine/(W) | Thermal energy exchange power/(W) | Heating efficiency/(%) | System efficiency/(%) |
---|---|---|---|---|
7.0 | 49.30 | 8.71 | 16.67 | 3.57 |
8.0 | 96.17 | 27.91 | 29.02 | 7.66 |
9.0 | 145.75 | 49.66 | 34.07 | 9.57 |
10.0 | 207.76 | 78.93 | 37.99 | 11.09 |
11.0 | 279.37 | 115.60 | 41.38 | 12.21 |
12.0 | 365.15 | 163.58 | 40.80 | 13.31 |
13.0 | 461.13 | 222.50 | 48.25 | 14.23 |
The heating efficiency and system efficiency of the liquid stirring heater.
According to Table 5, Figures 16 and 17, the heating efficiency increases with the wind speed increased in the test wind speed range, and the maximum efficiency is 48% when the wind speed is 13 m/s. The corresponding wind energy utilization coefficient is 0.295 with the highest system efficiency. Though the permanent magnet eddy current heater efficiency is high, while the matching characteristics with the wind turbine are poor, leading to low system efficiency. Thus, the good matching of heater and wind turbine will effectively improve the efficiency of the wind energy heating system.
Curve of the heating efficiency change at 7–13 m/s wind speeds.
Curve of the system efficiency change at 7–13 m/s wind speeds.
According to the existing experimental results, the numerical simulation method is applied to study the vertical axis wind turbine under different working conditions, the conclusion are as follows:
The input torque of the liquid stirring heater has a linear relationship with the rotating speed when its geometric structure and working fluid are determined. Therefore, replacing the working quality with high viscosity can effectively reduce the volume of the heating device. On the basis of guaranteeing the quantity of heat, optimizing the type of the stirring blade and flow resistance plate can reduce the working speed of the device, achieve a good match with the wind machine, improve the utilization coefficient of the wind turbine, and improve the heating efficiency of the system. According to the numerical simulation results, the maximum heating efficiency is up to 48.25%.
Compared with the liquid stirring heater in the same power level, the starting torque of the permanent magnet eddy current heater is higher, and due to the poor self-starting characteristics of the vertical axis wind turbine, the permanent magnet eddy current heater driven by the wind turbine can be put into operation at high wind speed, which cannot effectively use the wind energy at low wind speed. The wind energy utilization coefficient of the system can be improved by the cooperative operation with the liquid stirring heater. According to the numerical simulation results, the maximum heating efficiency is up to 72.21%.
The heater directly driven by a vertical axis wind turbine system has a certain referred significance for other permanent magnet eddy current heater and liquid stirring heater with vertical axis wind turbine.
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Robles",coverURL:"https://cdn.intechopen.com/books/images_new/10746.jpg",editedByType:"Edited by",editors:[{id:"219102",title:"Dr.",name:"Elena",middleName:null,surname:"Franco-Robles",slug:"elena-franco-robles",fullName:"Elena Franco-Robles"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9008",title:"Vitamin K",subtitle:"Recent Topics on the Biology and Chemistry",isOpenForSubmission:!1,hash:"8b43add5389ba85743e0a9491e4b9943",slug:"vitamin-k-recent-topics-on-the-biology-and-chemistry",bookSignature:"Hiroyuki Kagechika and Hitoshi Shirakawa",coverURL:"https://cdn.intechopen.com/books/images_new/9008.jpg",editedByType:"Edited by",editors:[{id:"180528",title:"Dr.",name:"Hiroyuki",middleName:null,surname:"Kagechika",slug:"hiroyuki-kagechika",fullName:"Hiroyuki Kagechika"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10745",title:"Nematodes",subtitle:"Recent Advances, Management and New Perspectives",isOpenForSubmission:!1,hash:"975ef07a02e028baac4d50b9f0a733b5",slug:"nematodes-recent-advances-management-and-new-perspectives",bookSignature:"Cristiano and Tiago Edu Kaspary",coverURL:"https://cdn.intechopen.com/books/images_new/10745.jpg",editedByType:"Edited by",editors:[{id:"274523",title:"Dr.",name:"Cristiano",middleName:null,surname:"Bellé",slug:"cristiano-belle",fullName:"Cristiano Bellé"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11021",title:"B-Complex Vitamins",subtitle:"Sources, Intakes and Novel Applications",isOpenForSubmission:!1,hash:"ad50bc292cda8d24f11aef2f5ef88f51",slug:"b-complex-vitamins-sources-intakes-and-novel-applications",bookSignature:"Jean Guy LeBlanc",coverURL:"https://cdn.intechopen.com/books/images_new/11021.jpg",editedByType:"Edited by",editors:[{id:"67023",title:"Dr.",name:"Jean Guy",middleName:null,surname:"LeBlanc",slug:"jean-guy-leblanc",fullName:"Jean Guy LeBlanc"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],booksByTopicTotal:312,seriesByTopicCollection:[],seriesByTopicTotal:0,mostCitedChapters:[{id:"38477",doi:"10.5772/45943",title:"Lipid Peroxidation: Chemical Mechanism, Biological Implications and Analytical Determination",slug:"lipid-peroxidation-chemical-mechanism-biological-implications-and-analytical-determination",totalDownloads:13516,totalCrossrefCites:80,totalDimensionsCites:223,abstract:null,book:{id:"2553",slug:"lipid-peroxidation",title:"Lipid Peroxidation",fullTitle:"Lipid Peroxidation"},signatures:"Marisa Repetto, Jimena Semprine and Alberto Boveris",authors:[{id:"36452",title:"Dr.",name:"Marisa",middleName:"Gabriela",surname:"Repetto",slug:"marisa-repetto",fullName:"Marisa Repetto"}]},{id:"41116",doi:"10.5772/51572",title:"Algal Polysaccharides, Novel Applications and Outlook",slug:"algal-polysaccharides-novel-applications-and-outlook",totalDownloads:14079,totalCrossrefCites:71,totalDimensionsCites:187,abstract:null,book:{id:"2323",slug:"carbohydrates-comprehensive-studies-on-glycobiology-and-glycotechnology",title:"Carbohydrates",fullTitle:"Carbohydrates - Comprehensive Studies on Glycobiology and Glycotechnology"},signatures:"Stefan Kraan",authors:[{id:"142720",title:"Dr.",name:"Stefan",middleName:null,surname:"Kraan",slug:"stefan-kraan",fullName:"Stefan Kraan"}]},{id:"40938",doi:"10.5772/48294",title:"Dehydrogenase Activity in the Soil Environment",slug:"dehydrogenase-activity-in-the-soil-environment",totalDownloads:6940,totalCrossrefCites:72,totalDimensionsCites:182,abstract:null,book:{id:"2524",slug:"dehydrogenases",title:"Dehydrogenases",fullTitle:"Dehydrogenases"},signatures:"Agnieszka Wolińska and Zofia Stępniewska",authors:[{id:"141696",title:"Dr.",name:"Agnieszka",middleName:"Maria",surname:"Wolinska",slug:"agnieszka-wolinska",fullName:"Agnieszka Wolinska"}]},{id:"18396",doi:"10.5772/22331",title:"Salinity Stress and Salt Tolerance",slug:"salinity-stress-and-salt-tolerance",totalDownloads:21995,totalCrossrefCites:56,totalDimensionsCites:161,abstract:null,book:{id:"371",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",title:"Abiotic Stress in Plants",fullTitle:"Abiotic Stress in Plants - Mechanisms and Adaptations"},signatures:"Petronia Carillo, Maria Grazia Annunziata, Giovanni Pontecorvo, Amodio Fuggi and Pasqualina Woodrow",authors:[{id:"47290",title:"Prof.",name:"Giovanni",middleName:null,surname:"Pontecorvo",slug:"giovanni-pontecorvo",fullName:"Giovanni Pontecorvo"},{id:"47803",title:"Dr.",name:"Pasqualina",middleName:null,surname:"Woodrow",slug:"pasqualina-woodrow",fullName:"Pasqualina Woodrow"},{id:"47804",title:"Prof.",name:"Petronia",middleName:null,surname:"Carillo",slug:"petronia-carillo",fullName:"Petronia Carillo"},{id:"47808",title:"Prof.",name:"Amodio",middleName:null,surname:"Fuggi",slug:"amodio-fuggi",fullName:"Amodio Fuggi"},{id:"47809",title:"Dr.",name:"Maria Grazia",middleName:null,surname:"Annunziata",slug:"maria-grazia-annunziata",fullName:"Maria Grazia Annunziata"}]},{id:"57644",doi:"10.5772/intechopen.71570",title:"Polysaccharides: Structure and Solubility",slug:"polysaccharides-structure-and-solubility",totalDownloads:4480,totalCrossrefCites:41,totalDimensionsCites:121,abstract:"Understanding the solubility of polysaccharides is extremely important for their food applications as most functions of polysaccharides including stability, emulsifying property, drug delivery, membrane forming properties, etc., are all achieved in aqueous solution. This chapter aims specifically at the mechanism of solubility of polysaccharides from the molecular level. General understandings of the solubility including definition, testing methods, and the solution behaviors were provided; the relationships between polysaccharide solubility and the structural features in terms of molecular weight, degree of branching, charging properties, chain flexibility, and the special groups were all discussed. With all the information provided, the molecular modification and further applications of polysaccharides in both food and nonfood areas could be promoted.",book:{id:"5935",slug:"solubility-of-polysaccharides",title:"Solubility of Polysaccharides",fullTitle:"Solubility of Polysaccharides"},signatures:"Mark Q. Guo, Xinzhong Hu, Changlu Wang and Lianzhong Ai",authors:[{id:"202384",title:"Dr.",name:"Qingbin",middleName:null,surname:"Guo",slug:"qingbin-guo",fullName:"Qingbin Guo"},{id:"203883",title:"Dr.",name:"Changlu",middleName:null,surname:"Wang",slug:"changlu-wang",fullName:"Changlu Wang"},{id:"203884",title:"Prof.",name:"Xinzhong",middleName:null,surname:"Hu",slug:"xinzhong-hu",fullName:"Xinzhong Hu"}]}],mostDownloadedChaptersLast30Days:[{id:"69775",title:"Principles of Chromatography Method Development",slug:"principles-of-chromatography-method-development",totalDownloads:4293,totalCrossrefCites:5,totalDimensionsCites:11,abstract:"This chapter aims to explain the key parameters of analytical method development using the chromatography techniques which are used for the identification, separation, purification, and quantitative estimation of complex mixtures of organic compounds. Mainly, the versatile techniques of ultra−/high-performance liquid chromatography (UPLC/HPLC) are in use for the analysis of assay and organic impurities/related substances/degradation products of a drug substance or drug product or intermediate or raw material of pharmaceuticals. A suitable analytical method is developed only after evaluating the major and critical separation parameters of chromatography (examples for UPLC/HPLC are selection of diluent, wavelength, detector, stationary phase, column temperature, flow rate, solvent system, elution mode, and injection volume, etc.). The analytical method development is a process of proving the developed analytical method is suitable for its intended use for the quantitative estimation of the targeted analyte present in pharmaceutical drugs. And it mostly plays a vital role in the development and manufacture of pharmaceuticals drugs.",book:{id:"8912",slug:"biochemical-analysis-tools-methods-for-bio-molecules-studies",title:"Biochemical Analysis Tools",fullTitle:"Biochemical Analysis Tools - Methods for Bio-Molecules Studies"},signatures:"Narasimha S. Lakka and Chandrasekar Kuppan",authors:[{id:"304950",title:"Prof.",name:"Chandrasekar",middleName:null,surname:"Kuppan",slug:"chandrasekar-kuppan",fullName:"Chandrasekar Kuppan"},{id:"309984",title:"Mr.",name:"Narasimha S",middleName:null,surname:"Lakka",slug:"narasimha-s-lakka",fullName:"Narasimha S Lakka"}]},{id:"33046",title:"Affinity Chromatography: Principles and Applications",slug:"affinity-chromatography-principles-and-applications",totalDownloads:48679,totalCrossrefCites:8,totalDimensionsCites:21,abstract:null,book:{id:"1490",slug:"affinity-chromatography",title:"Affinity Chromatography",fullTitle:"Affinity Chromatography"},signatures:"Sameh Magdeldin and Annette Moser",authors:[{id:"123648",title:"Dr.",name:"Sameh",middleName:null,surname:"Magdeldin",slug:"sameh-magdeldin",fullName:"Sameh Magdeldin"},{id:"136483",title:"Dr.",name:"Annette",middleName:"C.",surname:"Moser",slug:"annette-moser",fullName:"Annette Moser"}]},{id:"50574",title:"Bioinformatics for RNA‐Seq Data Analysis",slug:"bioinformatics-for-rna-seq-data-analysis",totalDownloads:6047,totalCrossrefCites:6,totalDimensionsCites:7,abstract:"While RNA sequencing (RNA‐seq) has become increasingly popular for transcriptome profiling, the analysis of the massive amount of data generated by large‐scale RNA‐seq still remains a challenge. RNA‐seq data analyses typically consist of (1) accurate mapping of millions of short sequencing reads to a reference genome, including the identification of splicing events; (2) quantifying expression levels of genes, transcripts, and exons; (3) differential analysis of gene expression among different biological conditions; and (4) biological interpretation of differentially expressed genes. Despite the fact that multiple algorithms pertinent to basic analyses have been developed, there are still a variety of unresolved questions. In this chapter, we review the main tools and algorithms currently available for RNA‐seq data analyses, and our goal is to help RNA‐seq data analysts to make an informed choice of tools in practical RNA‐seq data analysis. In the meantime, RNA‐seq is evolving rapidly, and newer sequencing technologies are briefly introduced, including stranded RNA‐seq, targeted RNA‐seq, and single‐cell RNA‐seq.",book:{id:"5160",slug:"bioinformatics-updated-features-and-applications",title:"Bioinformatics",fullTitle:"Bioinformatics - Updated Features and Applications"},signatures:"Shanrong Zhao, Baohong Zhang, Ying Zhang, William Gordon,\nSarah Du, Theresa Paradis, Michael Vincent and David von Schack",authors:[{id:"176364",title:"Dr.",name:"Shanrong",middleName:null,surname:"Zhao",slug:"shanrong-zhao",fullName:"Shanrong Zhao"}]},{id:"49873",title:"An Introduction to Actinobacteria",slug:"an-introduction-to-actinobacteria",totalDownloads:8178,totalCrossrefCites:33,totalDimensionsCites:108,abstract:"Actinobacteria, which share the characteristics of both bacteria and fungi, are widely distributed in both terrestrial and aquatic ecosystems, mainly in soil, where they play an essential role in recycling refractory biomaterials by decomposing complex mixtures of polymers in dead plants and animals and fungal materials. They are considered as the biotechnologically valuable bacteria that are exploited for its secondary metabolite production. Approximately, 10,000 bioactive metabolites are produced by Actinobacteria, which is 45% of all bioactive microbial metabolites discovered. Especially Streptomyces species produce industrially important microorganisms as they are a rich source of several useful bioactive natural products with potential applications. Though it has various applications, some Actinobacteria have its own negative effect against plants, animals, and humans. On this context, this chapter summarizes the general characteristics of Actinobacteria, its habitat, systematic classification, various biotechnological applications, and negative impact on plants and animals.",book:{id:"5056",slug:"actinobacteria-basics-and-biotechnological-applications",title:"Actinobacteria",fullTitle:"Actinobacteria - Basics and Biotechnological Applications"},signatures:"Ranjani Anandan, Dhanasekaran Dharumadurai and Gopinath\nPonnusamy Manogaran",authors:[{id:"48914",title:"Dr.",name:"Dharumadurai",middleName:null,surname:"Dhanasekaran",slug:"dharumadurai-dhanasekaran",fullName:"Dharumadurai Dhanasekaran"}]},{id:"72074",title:"The Chemistry Behind Plant DNA Isolation Protocols",slug:"the-chemistry-behind-plant-dna-isolation-protocols",totalDownloads:3797,totalCrossrefCites:4,totalDimensionsCites:7,abstract:"Various plant species are biochemically heterogeneous in nature, a single deoxyribose nucleic acid (DNA) isolation protocol may not be suitable. There have been continuous modification and standardization in DNA isolation protocols. Most of the plant DNA isolation protocols used today are modified versions of hexadecyltrimethyl-ammonium bromide (CTAB) extraction procedure. Modification is usually performed in the concentration of chemicals used during the extraction procedure according to the plant species and plant part used. Thus, understanding the role of each chemical (viz. CTAB, NaCl, PVP, ethanol, and isopropanol) used during the DNA extraction procedure will benefit to set or modify protocols for more precisions. A review of the chemicals used in the CTAB method of DNA extraction and their probable functions on the highly evolved yet complex to students and researchers has been summarized.",book:{id:"8912",slug:"biochemical-analysis-tools-methods-for-bio-molecules-studies",title:"Biochemical Analysis Tools",fullTitle:"Biochemical Analysis Tools - Methods for Bio-Molecules Studies"},signatures:"Jina Heikrujam, Rajkumar Kishor and Pranab Behari Mazumder",authors:[{id:"74521",title:"Dr.",name:"Rajkumar",middleName:null,surname:"Kishor",slug:"rajkumar-kishor",fullName:"Rajkumar Kishor"},{id:"309357",title:"Prof.",name:"Pranab Behari",middleName:null,surname:"Mazumder",slug:"pranab-behari-mazumder",fullName:"Pranab Behari Mazumder"},{id:"318351",title:"Ph.D. Student",name:"Jina",middleName:null,surname:"Heikrujam",slug:"jina-heikrujam",fullName:"Jina Heikrujam"}]}],onlineFirstChaptersFilter:{topicId:"6",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"83046",title:"Gene Expression and Transcriptome Sequencing: Basics, Analysis, Advances",slug:"gene-expression-and-transcriptome-sequencing-basics-analysis-advances",totalDownloads:2,totalDimensionsCites:0,doi:"10.5772/intechopen.105929",abstract:"Gene expression studies are extremely useful for understanding a broad range of biological, physiological, and molecular responses. The techniques for gene expression reflect differential patterns of gene regulation and have evolved with time from detecting one gene to many genes at a time laterally. Gene expression depends on the spatiotemporal expression in a particular tissue at a given time point and needs critical examination and interpretation. Transcriptome sequencing or RNA-seq using next-generation sequencing (short and long reads) is the most widely deployed technology for accurate quantification of gene expression. According to the biological aim of the experiment, replications, platform, and chemistries, propelling improvement has been demonstrated and documented using RNA-seq in plants, humans, animals, and clinical sciences with respect to gene expression of mRNA, small non-coding, long non-coding RNAs, alternative splice variations, isoform variations, gene fusions, single-nucleotide variants. Integrating transcriptome sequencing with other techniques such as chromatin immunoprecipitation, methylation, genome-wide association studies, manifests insights into genetic and epigenetic regulation. Epi-transcriptome including RNA methylation, modification, and alternative polyadenylation events can also be explored through long-read sequencing. In this chapter, we have presented an account of the basics of gene expression methods, transcriptome sequencing, and the various methodologies involved in the downstream analysis.",book:{id:"11349",title:"Gene Expression",coverURL:"https://cdn.intechopen.com/books/images_new/11349.jpg"},signatures:"Yogesh Shukla, Amol Phule, Harshvardhan Zala, Nakul D. Magar, Priya Shah, K. Harish, Tejas C. Bosamia, Kalyani M. Barbadikar, Maganti Sheshu Madhav, Satendra Kumar Mangrauthia, Chirravuri Naga Neeraja and Raman Meenakshi Sundaram"},{id:"83043",title:"Applications of CRISPR/Cas9 for Selective Sequencing and Clinical Diagnostics",slug:"applications-of-crispr-cas9-for-selective-sequencing-and-clinical-diagnostics",totalDownloads:5,totalDimensionsCites:0,doi:"10.5772/intechopen.106548",abstract:"In this chapter, we will discuss the applications of CRISPR/Cas9 in the context of clinical diagnostics. We will provide an overview of existing methods and their use cases in the diagnostic field. Special attention will be given to selective sequencing approaches using third-generation sequencing and PAM-site requirements. As target sequences in an AT-rich environment cannot easily be accessed by the commercially available SpCas9 due to rarity of NGG PAM-sites, new enzymes such as ScCas9 with PAM-site requirements of NNG will be highlighted. Original research on CRISPR/Cas9 systems to determine molecular glioma markers by enriching regions of interest will be discussed in the context of potential future applications in clinical diagnostics.",book:{id:"11804",title:"CRISPR Technology",coverURL:"https://cdn.intechopen.com/books/images_new/11804.jpg"},signatures:"Maximilian Evers, Björn Brändl, Franz-Josef Müller, Sönke Friedrichsen and Stephan Kolkenbrock"},{id:"82914",title:"Glance on the Critical Role of IL-23 Receptor Gene Variations in Inflammation-Induced Carcinogenesis",slug:"glance-on-the-critical-role-of-il-23-receptor-gene-variations-in-inflammation-induced-carcinogenesis",totalDownloads:15,totalDimensionsCites:0,doi:"10.5772/intechopen.105049",abstract:"In this chapter, we will discuss the importance of genetic variations in the IL-23 receptor (IL-23R) gene in driving the process of inflammation-induced carcinogenesis. By applying bladder cancer (BLC) as a model, we will focus on two contradictory genetic mutations within the receptor gene. The first one is enhanced by cancer and induces inflammation-induced carcinogenesis via up-regulating IL-23/IL-17 inflammatory axis. However, the other preventive one deregulates this inflammatory pathway by distorting the protein nature of the receptor, leading to block its binding affinity. During the process of carcinogenesis, cancer genetically inclines the balance towards the protumor, via over-expressing the IL-23R on the surfaces of immune-bearing cells, particularly tumor-associated monocytes (TAMs) and thus increasing the levels of pro-angiogenic cytokines IL-23 and IL-17.",book:{id:"11672",title:"Chemokines Updates",coverURL:"https://cdn.intechopen.com/books/images_new/11672.jpg"},signatures:"Mohammed El-Gedamy"},{id:"82259",title:"p53 Tumor Suppressor: Functional Regulation and Role in Gene Therapy",slug:"p53-tumor-suppressor-functional-regulation-and-role-in-gene-therapy",totalDownloads:7,totalDimensionsCites:0,doi:"10.5772/intechopen.105029",abstract:"p53, a homo-tetrameric protein found in mammalian cells, derives its name from the fact that it settles at around 53KDa position in SDS-PAGE, due to a “kink” in its structure. In its functional state, p53 forms a homo-tetramer and binds to the promoters of a wide array of genes. Binding of p53 downregulates the transcription of target genes. Most of the gene targets of p53 are involved in cell cycle progression, and therefore, any malfunctions associated with p53 have catastrophic consequences for the cell. The gene encoding for p53 known as TP53 is the most well-studied gene in the entire genome because of being the most highly mutated gene in all cancer types. It is due to this widely accepted and documented “cell protective feature” that p53 is generally referred to as “the guardian of the genome.” In this chapter, we will discuss the involvement of p53 in relation to carcinogenesis. We will also cover the major functions of p53 under normal conditions, major mutations of the TP53 gene, and their association with different forms of cancer.",book:{id:"10246",title:"P53 - A Guardian of the Genome and Beyond",coverURL:"https://cdn.intechopen.com/books/images_new/10246.jpg"},signatures:"Zeenat Farooq, Shahnawaz Wani, Vijay Avin BR, Rakesh Kochhar and Mumtaz Anwar"},{id:"82875",title:"Lipidomics as a Tool in the Diagnosis and Clinical Therapy",slug:"lipidomics-as-a-tool-in-the-diagnosis-and-clinical-therapy",totalDownloads:9,totalDimensionsCites:0,doi:"10.5772/intechopen.105857",abstract:"The lipids are essential compounds of cells, with biochemical and structural properties. Lipids are classified according to their chain length or saturation levels and biogenesis. Lipidomics is a spectroscopic and spectrometric technique, like Mass Spectrometry and Nuclear Magnetic Resonance, as well as bioinformatics to quantify and characterize the lipid profile. Lipidomics enables the fundamental understanding of lipid biology, the identification of drug targets for therapy, and the discovery of lipid biomarkers of disease cohorts. Therefore, lipidomics allows knowing the diagnosis and clinical follow-up in medical therapy towards any disease. In this way, the lipid profile allows us to monitor the administration of a clinical treatment and assertively diagnose human diseases.",book:{id:"11669",title:"Fatty Acids - Recent Advances",coverURL:"https://cdn.intechopen.com/books/images_new/11669.jpg"},signatures:"María Elizbeth Alvarez Sánchez, Erick Nolasco Ontiveros, Rodrigo Arreola, Adriana Montserrat Espinosa González, Ana María García Bores, Roberto Eduardo López Urrutia, Ignacio Peñalosa Castro, María del Socorro Sánchez Correa and Edgar Antonio Estrella Parra"},{id:"82862",title:"Assessment of Genetic Variability of Three Types of Sorghum Cultivated in Burkina Faso Using Morphoagronomic Quantitative Traits and Brix",slug:"assessment-of-genetic-variability-of-three-types-of-sorghum-cultivated-in-burkina-faso-using-morphoa",totalDownloads:16,totalDimensionsCites:0,doi:"10.5772/intechopen.105984",abstract:"In Burkina Faso, tree types of sorghum are mainly grown. Despite their genetic proximity revealed by molecular markers, the identification of distinctive agro-morphological traits between sweet grain sorghum, sweet sorghum and grain sorghum could contribute to better management of their genetic resources. Thus, 42 genotypes consisting of the three sorghum types were evaluated in a three replicate Fisher incomplete block design using 20 quantitative traits. The results showed a high variability of traits within each sorghum type and a greater closeness between sweet grain sorghum and sweet stalk sorghum. In addition, nine traits clearly discriminated sweet grain sorghum from the other sorghum types. Sweet grain sorghum expressed the highest values of the sowing-heading cycle, leaf sheath length, stem diameter, productive tillers, and panicle width and the lowest values of mean heading-flowering difference, 100-grain weight, and Brix. Moreover, the ‘sorghum type’ factor is less preponderant than the ‘genotype factor’ in expressing the variability of all traits. Therefore, the 42 genotypes are organized into three genetic groups independently of the sorghum- type factor, where the group I contains all sweet grain sorghum genotypes and three sweet stalk sorghum genotypes. These results could be exploited in sorghum breeding programs.",book:{id:"11643",title:"Genetic Diversity - Recent Advances and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/11643.jpg"},signatures:"Nerbéwendé Sawadogo, Mahamadi Hamed Ouédraogo, Lardia Ali Bougma, Norbert Yaméogo, Wendmanegda Hermann Tondé, Josiane Tiendrébéogo, Sévérin Tuina, Gapili Naoura and Mahamadou Sawadogo"}],onlineFirstChaptersTotal:92},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:108,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:330,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:9,numberOfPublishedChapters:141,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:124,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:22,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:11,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. 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Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. 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Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:4,paginationItems:[{id:"14",title:"Cell and Molecular Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",isOpenForSubmission:!0,annualVolume:11410,editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",slug:"rosa-maria-martinez-espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",biography:"Dr. Rosa María Martínez-Espinosa has been a Spanish Full Professor since 2020 (Biochemistry and Molecular Biology) and is currently Vice-President of International Relations and Cooperation development and leader of the research group 'Applied Biochemistry” (University of Alicante, Spain). Other positions she has held at the university include Vice-Dean of Master Programs, Vice-Dean of the Degree in Biology and Vice-Dean for Mobility and Enterprise and Engagement at the Faculty of Science (University of Alicante). She received her Bachelor in Biology in 1998 (University of Alicante) and her PhD in 2003 (Biochemistry, University of Alicante). She undertook post-doctoral research at the University of East Anglia (Norwich, U.K. 2004-2005; 2007-2008).\nHer multidisciplinary research focuses on investigating archaea and their potential applications in biotechnology. She has an H-index of 21. She has authored one patent and has published more than 70 indexed papers and around 60 book chapters.\nShe has contributed to more than 150 national and international meetings during the last 15 years. Her research interests include archaea metabolism, enzymes purification and characterization, gene regulation, carotenoids and bioplastics production, antioxidant\ncompounds, waste water treatments, and brines bioremediation.\nRosa María’s other roles include editorial board member for several journals related\nto biochemistry, reviewer for more than 60 journals (biochemistry, molecular biology, biotechnology, chemistry and microbiology) and president of several organizing committees in international meetings related to the N-cycle or respiratory processes.",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"15",title:"Chemical Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",isOpenForSubmission:!0,annualVolume:11411,editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",slug:"sukru-beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",biography:"Dr. Şükrü Beydemir obtained a BSc in Chemistry in 1995 from Yüzüncü Yıl University, MSc in Biochemistry in 1998, and PhD in Biochemistry in 2002 from Atatürk University, Turkey. 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She gained considerable experience in developing and validating new methodologies whose applications allowed her to determine both the amount of biomarkers (Desmosine and Isodesmosine) in the urine of patients affected by COPD, and the activity of proteolytic enzymes (HNE, Cathepsin G, Pseudomonas aeruginosa elastase) in the sputa of these patients. Simona Viglio was also involved in research dealing with the supplementation of amino acids in patients with brain injury and chronic heart failure. She is presently engaged in the development of 2-DE and LC-MS techniques for the study of proteomics in biological fluids. The aim of this research is the identification of potential biomarkers of lung diseases. 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Serves as a peer reviewer for biomedical journals. Military Reserve Officer serving with the 100 Support Command, 100 Troop Command, 40 Infantry Division, CA National Guard.",institutionString:null,institution:{name:"Loma Linda University",institutionURL:null,country:{name:"United States of America"}}}]},{type:"book",id:"6925",title:"Endoplasmic Reticulum",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6925.jpg",slug:"endoplasmic-reticulum",publishedDate:"April 17th 2019",editedByType:"Edited by",bookSignature:"Angel Català",hash:"a9e90d2dbdbc46128dfe7dac9f87c6b4",volumeInSeries:2,fullTitle:"Endoplasmic Reticulum",editors:[{id:"196544",title:"Prof.",name:"Angel",middleName:null,surname:"Catala",slug:"angel-catala",fullName:"Angel Catala",profilePictureURL:"https://mts.intechopen.com/storage/users/196544/images/system/196544.jpg",biography:"Angel Catalá studied chemistry at Universidad Nacional de La Plata, Argentina, where he received a Ph.D. in Chemistry (Biological Branch) in 1965. From 1964 to 1974, he worked as an Assistant in Biochemistry at the School of Medicine at the same university. From 1974 to 1976, he was a fellow of the National Institutes of Health (NIH) at the University of Connecticut, Health Center, USA. From 1985 to 2004, he served as a Full Professor of Biochemistry at the Universidad Nacional de La Plata. He is a member of the National Research Council (CONICET), Argentina, and the Argentine Society for Biochemistry and Molecular Biology (SAIB). His laboratory has been interested for many years in the lipid peroxidation of biological membranes from various tissues and different species. Dr. Catalá has directed twelve doctoral theses, published more than 100 papers in peer-reviewed journals, several chapters in books, and edited twelve books. He received awards at the 40th International Conference Biochemistry of Lipids 1999 in Dijon, France. He is the winner of the Bimbo Pan-American Nutrition, Food Science and Technology Award 2006 and 2012, South America, Human Nutrition, Professional Category. In 2006, he won the Bernardo Houssay award in pharmacology, in recognition of his meritorious works of research. Dr. Catalá belongs to the editorial board of several journals including Journal of Lipids; International Review of Biophysical Chemistry; Frontiers in Membrane Physiology and Biophysics; World Journal of Experimental Medicine and Biochemistry Research International; World Journal of Biological Chemistry, Diabetes, and the Pancreas; International Journal of Chronic Diseases & Therapy; and International Journal of Nutrition. He is the co-editor of The Open Biology Journal and associate editor for Oxidative Medicine and Cellular Longevity.",institutionString:"Universidad Nacional de La Plata",institution:{name:"National University of La Plata",institutionURL:null,country:{name:"Argentina"}}}]},{type:"book",id:"6924",title:"Adenosine Triphosphate in Health and Disease",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6924.jpg",slug:"adenosine-triphosphate-in-health-and-disease",publishedDate:"April 24th 2019",editedByType:"Edited by",bookSignature:"Gyula Mozsik",hash:"04106c232a3c68fec07ba7cf00d2522d",volumeInSeries:3,fullTitle:"Adenosine Triphosphate in Health and Disease",editors:[{id:"58390",title:"Dr.",name:"Gyula",middleName:null,surname:"Mozsik",slug:"gyula-mozsik",fullName:"Gyula Mozsik",profilePictureURL:"https://mts.intechopen.com/storage/users/58390/images/system/58390.png",biography:"Gyula Mózsik MD, Ph.D., ScD (med), is an emeritus professor of Medicine at the First Department of Medicine, Univesity of Pécs, Hungary. He was head of this department from 1993 to 2003. His specializations are medicine, gastroenterology, clinical pharmacology, clinical nutrition, and dietetics. His research fields are biochemical pharmacological examinations in the human gastrointestinal (GI) mucosa, mechanisms of retinoids, drugs, capsaicin-sensitive afferent nerves, and innovative pharmacological, pharmaceutical, and nutritional (dietary) research in humans. He has published about 360 peer-reviewed papers, 197 book chapters, 692 abstracts, 19 monographs, and has edited 37 books. He has given about 1120 regular and review lectures. He has organized thirty-eight national and international congresses and symposia. He is the founder of the International Conference on Ulcer Research (ICUR); International Union of Pharmacology, Gastrointestinal Section (IUPHAR-GI); Brain-Gut Society symposiums, and gastrointestinal cytoprotective symposiums. He received the Andre Robert Award from IUPHAR-GI in 2014. 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Currently, she is working as a Data Scientist with an MNC in Delhi, India.",institutionString:"NSHM College of Management and Technology",institution:{name:"Association for Computing Machinery",country:{name:"United States of America"}}},{id:"226240",title:"Dr.",name:"Andri Irfan",middleName:null,surname:"Rifai",slug:"andri-irfan-rifai",fullName:"Andri Irfan Rifai",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/226240/images/7412_n.jpg",biography:"Andri IRFAN is a Senior Lecturer of Civil Engineering and Planning. He completed the PhD at the Universitas Indonesia & Universidade do Minho with Sandwich Program Scholarship from the Directorate General of Higher Education and LPDP scholarship. He has been teaching for more than 19 years and much active to applied his knowledge in the project construction in Indonesia. His research interest ranges from pavement management system to advanced data mining techniques for transportation engineering. He has published more than 50 papers in journals and 2 books.",institutionString:null,institution:{name:"Universitas Internasional Batam",country:{name:"Indonesia"}}},{id:"314576",title:"Dr.",name:"Ibai",middleName:null,surname:"Laña",slug:"ibai-lana",fullName:"Ibai Laña",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/314576/images/system/314576.jpg",biography:"Dr. Ibai Laña works at TECNALIA as a data analyst. He received his Ph.D. in Artificial Intelligence from the University of the Basque Country (UPV/EHU), Spain, in 2018. He is currently a senior researcher at TECNALIA. His research interests fall within the intersection of intelligent transportation systems, machine learning, traffic data analysis, and data science. He has dealt with urban traffic forecasting problems, applying machine learning models and evolutionary algorithms. He has experience in origin-destination matrix estimation or point of interest and trajectory detection. Working with large volumes of data has given him a good command of big data processing tools and NoSQL databases. He has also been a visiting scholar at the Knowledge Engineering and Discovery Research Institute, Auckland University of Technology.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"314575",title:"Dr.",name:"Jesus",middleName:null,surname:"L. Lobo",slug:"jesus-l.-lobo",fullName:"Jesus L. Lobo",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/314575/images/system/314575.png",biography:"Dr. Jesús López is currently based in Bilbao (Spain) working at TECNALIA as Artificial Intelligence Research Scientist. In most cases, a project idea or a new research line needs to be investigated to see if it is good enough to take into production or to focus on it. That is exactly what he does, diving into Machine Learning algorithms and technologies to help TECNALIA to decide whether something is great in theory or will actually impact on the product or processes of its projects. So, he is expert at framing experiments, developing hypotheses, and proving whether they’re true or not, in order to investigate fundamental problems with a longer time horizon. He is also able to design and develop PoCs and system prototypes in simulation. He has participated in several national and internacional R&D projects.\n\nAs another relevant part of his everyday research work, he usually publishes his findings in reputed scientific refereed journals and international conferences, occasionally acting as reviewer and Programme Commitee member. Concretely, since 2018 he has published 9 JCR (8 Q1) journal papers, 9 conference papers (e.g. ECML PKDD 2021), and he has co-edited a book. He is also active in popular science writing data science stories for reputed blogs (KDNuggets, TowardsDataScience, Naukas). Besides, he has recently embarked on mentoring programmes as mentor, and has also worked as data science trainer.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"103779",title:"Prof.",name:"Yalcin",middleName:null,surname:"Isler",slug:"yalcin-isler",fullName:"Yalcin Isler",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRyQ8QAK/Profile_Picture_1628834958734",biography:"Yalcin Isler (1971 - Burdur / Turkey) received the B.Sc. degree in the Department of Electrical and Electronics Engineering from Anadolu University, Eskisehir, Turkey, in 1993, the M.Sc. degree from the Department of Electronics and Communication Engineering, Suleyman Demirel University, Isparta, Turkey, in 1996, the Ph.D. degree from the Department of Electrical and Electronics Engineering, Dokuz Eylul University, Izmir, Turkey, in 2009, and the Competence of Associate Professorship from the Turkish Interuniversity Council in 2019.\n\nHe was Lecturer at Burdur Vocational School in Suleyman Demirel University (1993-2000, Burdur / Turkey), Software Engineer (2000-2002, Izmir / Turkey), Research Assistant in Bulent Ecevit University (2002-2003, Zonguldak / Turkey), Research Assistant in Dokuz Eylul University (2003-2010, Izmir / Turkey), Assistant Professor at the Department of Electrical and Electronics Engineering in Bulent Ecevit University (2010-2012, Zonguldak / Turkey), Assistant Professor at the Department of Biomedical Engineering in Izmir Katip Celebi University (2012-2019, Izmir / Turkey). He is an Associate Professor at the Department of Biomedical Engineering at Izmir Katip Celebi University, Izmir / Turkey, since 2019. In addition to academics, he has also founded Islerya Medical and Information Technologies Company, Izmir / Turkey, since 2017.\n\nHis main research interests cover biomedical signal processing, pattern recognition, medical device design, programming, and embedded systems. He has many scientific papers and participated in several projects in these study fields. He was an IEEE Student Member (2009-2011) and IEEE Member (2011-2014) and has been IEEE Senior Member since 2014.",institutionString:null,institution:{name:"Izmir Kâtip Çelebi University",country:{name:"Turkey"}}},{id:"339677",title:"Dr.",name:"Mrinmoy",middleName:null,surname:"Roy",slug:"mrinmoy-roy",fullName:"Mrinmoy Roy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/339677/images/16768_n.jpg",biography:"An accomplished Sales & Marketing professional with 12 years of cross-functional experience in well-known organisations such as CIPLA, LUPIN, GLENMARK, ASTRAZENECA across different segment of Sales & Marketing, International Business, Institutional Business, Product Management, Strategic Marketing of HIV, Oncology, Derma, Respiratory, Anti-Diabetic, Nutraceutical & Stomatological Product Portfolio and Generic as well as Chronic Critical Care Portfolio. A First Class MBA in International Business & Strategic Marketing, B.Pharm, D.Pharm, Google Certified Digital Marketing Professional. Qualified PhD Candidate in Operations and Management with special focus on Artificial Intelligence and Machine Learning adoption, analysis and use in Healthcare, Hospital & Pharma Domain. Seasoned with diverse therapy area of Pharmaceutical Sales & Marketing ranging from generating revenue through generating prescriptions, launching new products, and making them big brands with continuous strategy execution at the Physician and Patients level. Moved from Sales to Marketing and Business Development for 3.5 years in South East Asian Market operating from Manila, Philippines. Came back to India and handled and developed Brands such as Gluconorm, Lupisulin, Supracal, Absolut Woman, Hemozink, Fabiflu (For COVID 19), and many more. In my previous assignment I used to develop and execute strategies on Sales & Marketing, Commercialization & Business Development for Institution and Corporate Hospital Business portfolio of Oncology Therapy Area for AstraZeneca Pharma India Ltd. Being a Research Scholar and Student of ‘Operations Research & Management: Artificial Intelligence’ I published several pioneer research papers and book chapters on the same in Internationally reputed journals and Books indexed in Scopus, Springer and Ei Compendex, Google Scholar etc. Currently, I am launching PGDM Pharmaceutical Management Program in IIHMR Bangalore and spearheading the course curriculum and structure of the same. I am interested in Collaboration for Healthcare Innovation, Pharma AI Innovation, Future trend in Marketing and Management with incubation on Healthcare, Healthcare IT startups, AI-ML Modelling and Healthcare Algorithm based training module development. I am also an affiliated member of the Institute of Management Consultant of India, looking forward to Healthcare, Healthcare IT and Innovation, Pharma and Hospital Management Consulting works.",institutionString:null,institution:{name:"Lovely Professional University",country:{name:"India"}}},{id:"310576",title:"Prof.",name:"Erick Giovani",middleName:null,surname:"Sperandio Nascimento",slug:"erick-giovani-sperandio-nascimento",fullName:"Erick Giovani Sperandio Nascimento",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0033Y00002pDKxDQAW/ProfilePicture%202022-06-20%2019%3A57%3A24.788",biography:"Prof. Erick Sperandio is the Lead Researcher and professor of Artificial Intelligence (AI) at SENAI CIMATEC, Bahia, Brazil, also working with Computational Modeling (CM) and HPC. He holds a PhD in Environmental Engineering in the area of Atmospheric Computational Modeling, a Master in Informatics in the field of Computational Intelligence and Graduated in Computer Science from UFES. He currently coordinates, leads and participates in R&D projects in the areas of AI, computational modeling and supercomputing applied to different areas such as Oil and Gas, Health, Advanced Manufacturing, Renewable Energies and Atmospheric Sciences, advising undergraduate, master's and doctoral students. He is the Lead Researcher at SENAI CIMATEC's Reference Center on Artificial Intelligence. In addition, he is a Certified Instructor and University Ambassador of the NVIDIA Deep Learning Institute (DLI) in the areas of Deep Learning, Computer Vision, Natural Language Processing and Recommender Systems, and Principal Investigator of the NVIDIA/CIMATEC AI Joint Lab, the first in Latin America within the NVIDIA AI Technology Center (NVAITC) worldwide program. He also works as a researcher at the Supercomputing Center for Industrial Innovation (CS2i) and at the SENAI Institute of Innovation for Automation (ISI Automação), both from SENAI CIMATEC. He is a member and vice-coordinator of the Basic Board of Scientific-Technological Advice and Evaluation, in the area of Innovation, of the Foundation for Research Support of the State of Bahia (FAPESB). He serves as Technology Transfer Coordinator and one of the Principal Investigators at the National Applied Research Center in Artificial Intelligence (CPA-IA) of SENAI CIMATEC, focusing on Industry, being one of the six CPA-IA in Brazil approved by MCTI / FAPESP / CGI.br. He also participates as one of the representatives of Brazil in the BRICS Innovation Collaboration Working Group on HPC, ICT and AI. He is the coordinator of the Work Group of the Axis 5 - Workforce and Training - of the Brazilian Strategy for Artificial Intelligence (EBIA), and member of the MCTI/EMBRAPII AI Innovation Network Training Committee. He is the coordinator, by SENAI CIMATEC, of the Artificial Intelligence Reference Network of the State of Bahia (REDE BAH.IA). He leads the working group of experts representing Brazil in the Global Partnership on Artificial Intelligence (GPAI), on the theme \"AI and the Pandemic Response\".",institutionString:"Manufacturing and Technology Integrated Campus – SENAI CIMATEC",institution:null},{id:"1063",title:"Prof.",name:"Constantin",middleName:null,surname:"Volosencu",slug:"constantin-volosencu",fullName:"Constantin Volosencu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/1063/images/system/1063.png",biography:"Prof. Dr. Constantin Voloşencu graduated as an engineer from\nPolitehnica University of Timișoara, Romania, where he also\nobtained a doctorate degree. He is currently a full professor in\nthe Department of Automation and Applied Informatics at the\nsame university. Dr. Voloşencu is the author of ten books, seven\nbook chapters, and more than 160 papers published in journals\nand conference proceedings. He has also edited twelve books and\nhas twenty-seven patents to his name. He is a manager of research grants, editor in\nchief and member of international journal editorial boards, a former plenary speaker, a member of scientific committees, and chair at international conferences. His\nresearch is in the fields of control systems, control of electric drives, fuzzy control\nsystems, neural network applications, fault detection and diagnosis, sensor network\napplications, monitoring of distributed parameter systems, and power ultrasound\napplications. He has developed automation equipment for machine tools, spooling\nmachines, high-power ultrasound processes, and more.",institutionString:'"Politechnica" University Timişoara',institution:null},{id:"221364",title:"Dr.",name:"Eneko",middleName:null,surname:"Osaba",slug:"eneko-osaba",fullName:"Eneko Osaba",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/221364/images/system/221364.jpg",biography:"Dr. Eneko Osaba works at TECNALIA as a senior researcher. He obtained his Ph.D. in Artificial Intelligence in 2015. He has participated in more than twenty-five local and European research projects, and in the publication of more than 130 papers. He has performed several stays at universities in the United Kingdom, Italy, and Malta. Dr. Osaba has served as a program committee member in more than forty international conferences and participated in organizing activities in more than ten international conferences. He is a member of the editorial board of the International Journal of Artificial Intelligence, Data in Brief, and Journal of Advanced Transportation. He is also a guest editor for the Journal of Computational Science, Neurocomputing, Swarm, and Evolutionary Computation and IEEE ITS Magazine.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"275829",title:"Dr.",name:"Esther",middleName:null,surname:"Villar-Rodriguez",slug:"esther-villar-rodriguez",fullName:"Esther Villar-Rodriguez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/275829/images/system/275829.jpg",biography:"Dr. Esther Villar obtained a Ph.D. in Information and Communication Technologies from the University of Alcalá, Spain, in 2015. She obtained a degree in Computer Science from the University of Deusto, Spain, in 2010, and an MSc in Computer Languages and Systems from the National University of Distance Education, Spain, in 2012. Her areas of interest and knowledge include natural language processing (NLP), detection of impersonation in social networks, semantic web, and machine learning. Dr. Esther Villar made several contributions at conferences and publishing in various journals in those fields. Currently, she is working within the OPTIMA (Optimization Modeling & Analytics) business of TECNALIA’s ICT Division as a data scientist in projects related to the prediction and optimization of management and industrial processes (resource planning, energy efficiency, etc).",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"49813",title:"Dr.",name:"Javier",middleName:null,surname:"Del Ser",slug:"javier-del-ser",fullName:"Javier Del Ser",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49813/images/system/49813.png",biography:"Prof. Dr. Javier Del Ser received his first PhD in Telecommunication Engineering (Cum Laude) from the University of Navarra, Spain, in 2006, and a second PhD in Computational Intelligence (Summa Cum Laude) from the University of Alcala, Spain, in 2013. He is currently a principal researcher in data analytics and optimisation at TECNALIA (Spain), a visiting fellow at the Basque Center for Applied Mathematics (BCAM) and a part-time lecturer at the University of the Basque Country (UPV/EHU). His research interests gravitate on the use of descriptive, prescriptive and predictive algorithms for data mining and optimization in a diverse range of application fields such as Energy, Transport, Telecommunications, Health and Industry, among others. In these fields he has published more than 240 articles, co-supervised 8 Ph.D. theses, edited 6 books, coauthored 7 patents and participated/led more than 40 research projects. He is a Senior Member of the IEEE, and a recipient of the Biscay Talent prize for his academic career.",institutionString:"Tecnalia Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"278948",title:"Dr.",name:"Carlos Pedro",middleName:null,surname:"Gonçalves",slug:"carlos-pedro-goncalves",fullName:"Carlos Pedro Gonçalves",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRcmyQAC/Profile_Picture_1564224512145",biography:'Carlos Pedro Gonçalves (PhD) is an Associate Professor at Lusophone University of Humanities and Technologies and a researcher on Complexity Sciences, Quantum Technologies, Artificial Intelligence, Strategic Studies, Studies in Intelligence and Security, FinTech and Financial Risk Modeling. He is also a progammer with programming experience in:\n\nA) Quantum Computing using Qiskit Python module and IBM Quantum Experience Platform, with software developed on the simulation of Quantum Artificial Neural Networks and Quantum Cybersecurity;\n\nB) Artificial Intelligence and Machine learning programming in Python;\n\nC) Artificial Intelligence, Multiagent Systems Modeling and System Dynamics Modeling in Netlogo, with models developed in the areas of Chaos Theory, Econophysics, Artificial Intelligence, Classical and Quantum Complex Systems Science, with the Econophysics models having been cited worldwide and incorporated in PhD programs by different Universities.\n\nReceived an Arctic Code Vault Contributor status by GitHub, due to having developed open source software preserved in the \\"Arctic Code Vault\\" for future generations (https://archiveprogram.github.com/arctic-vault/), with the Strategy Analyzer A.I. module for decision making support (based on his PhD thesis, used in his Classes on Decision Making and in Strategic Intelligence Consulting Activities) and QNeural Python Quantum Neural Network simulator also preserved in the \\"Arctic Code Vault\\", for access to these software modules see: https://github.com/cpgoncalves. He is also a peer reviewer with outsanding review status from Elsevier journals, including Physica A, Neurocomputing and Engineering Applications of Artificial Intelligence. Science CV available at: https://www.cienciavitae.pt//pt/8E1C-A8B3-78C5 and ORCID: https://orcid.org/0000-0002-0298-3974',institutionString:"University of Lisbon",institution:{name:"Universidade Lusófona",country:{name:"Portugal"}}},{id:"241400",title:"Prof.",name:"Mohammed",middleName:null,surname:"Bsiss",slug:"mohammed-bsiss",fullName:"Mohammed Bsiss",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/241400/images/8062_n.jpg",biography:null,institutionString:null,institution:null},{id:"276128",title:"Dr.",name:"Hira",middleName:null,surname:"Fatima",slug:"hira-fatima",fullName:"Hira Fatima",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/276128/images/14420_n.jpg",biography:"Dr. Hira Fatima\nAssistant Professor\nDepartment of Mathematics\nInstitute of Applied Science\nMangalayatan University, Aligarh\nMobile: no : 8532041179\nhirafatima2014@gmal.com\n\nDr. Hira Fatima has received his Ph.D. degree in pure Mathematics from Aligarh Muslim University, Aligarh India. Currently working as an Assistant Professor in the Department of Mathematics, Institute of Applied Science, Mangalayatan University, Aligarh. She taught so many courses of Mathematics of UG and PG level. Her research Area of Expertise is Functional Analysis & Sequence Spaces. She has been working on Ideal Convergence of double sequence. She has published 17 research papers in National and International Journals including Cogent Mathematics, Filomat, Journal of Intelligent and Fuzzy Systems, Advances in Difference Equations, Journal of Mathematical Analysis, Journal of Mathematical & Computer Science etc. She has also reviewed few research papers for the and international journals. She is a member of Indian Mathematical Society.",institutionString:null,institution:null},{id:"414880",title:"Dr.",name:"Maryam",middleName:null,surname:"Vatankhah",slug:"maryam-vatankhah",fullName:"Maryam Vatankhah",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Borough of Manhattan Community College",country:{name:"United States of America"}}},{id:"414879",title:"Prof.",name:"Mohammad-Reza",middleName:null,surname:"Akbarzadeh-Totonchi",slug:"mohammad-reza-akbarzadeh-totonchi",fullName:"Mohammad-Reza Akbarzadeh-Totonchi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Ferdowsi University of Mashhad",country:{name:"Iran"}}},{id:"414878",title:"Prof.",name:"Reza",middleName:null,surname:"Fazel-Rezai",slug:"reza-fazel-rezai",fullName:"Reza Fazel-Rezai",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"American Public University System",country:{name:"United States of America"}}},{id:"426586",title:"Dr.",name:"Oladunni A.",middleName:null,surname:"Daramola",slug:"oladunni-a.-daramola",fullName:"Oladunni A. Daramola",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Federal University of Technology",country:{name:"Nigeria"}}},{id:"357014",title:"Prof.",name:"Leon",middleName:null,surname:"Bobrowski",slug:"leon-bobrowski",fullName:"Leon Bobrowski",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Bialystok University of Technology",country:{name:"Poland"}}},{id:"302698",title:"Dr.",name:"Yao",middleName:null,surname:"Shan",slug:"yao-shan",fullName:"Yao Shan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Dalian University of Technology",country:{name:"China"}}},{id:"354126",title:"Dr.",name:"Setiawan",middleName:null,surname:"Hadi",slug:"setiawan-hadi",fullName:"Setiawan Hadi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Padjadjaran University",country:{name:"Indonesia"}}},{id:"125911",title:"Prof.",name:"Jia-Ching",middleName:null,surname:"Wang",slug:"jia-ching-wang",fullName:"Jia-Ching Wang",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"National Central University",country:{name:"Taiwan"}}},{id:"332603",title:"Prof.",name:"Kumar S.",middleName:null,surname:"Ray",slug:"kumar-s.-ray",fullName:"Kumar S. Ray",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Indian Statistical Institute",country:{name:"India"}}},{id:"415409",title:"Prof.",name:"Maghsoud",middleName:null,surname:"Amiri",slug:"maghsoud-amiri",fullName:"Maghsoud Amiri",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Allameh Tabataba'i University",country:{name:"Iran"}}},{id:"357085",title:"Mr.",name:"P. Mohan",middleName:null,surname:"Anand",slug:"p.-mohan-anand",fullName:"P. Mohan Anand",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Indian Institute of Technology Kanpur",country:{name:"India"}}},{id:"356696",title:"Ph.D. Student",name:"P.V.",middleName:null,surname:"Sai Charan",slug:"p.v.-sai-charan",fullName:"P.V. Sai Charan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Indian Institute of Technology Kanpur",country:{name:"India"}}},{id:"357086",title:"Prof.",name:"Sandeep K.",middleName:null,surname:"Shukla",slug:"sandeep-k.-shukla",fullName:"Sandeep K. Shukla",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Indian Institute of Technology Kanpur",country:{name:"India"}}}]}},subseries:{item:{id:"14",type:"subseries",title:"Cell and Molecular Biology",keywords:"Omics (Transcriptomics; Proteomics; Metabolomics), Molecular Biology, Cell Biology, Signal Transduction and Regulation, Cell Growth and Differentiation, Apoptosis, Necroptosis, Ferroptosis, Autophagy, Cell Cycle, Macromolecules and Complexes, Gene Expression",scope:"The Cell and Molecular Biology topic within the IntechOpen Biochemistry Series aims to rapidly publish contributions on all aspects of cell and molecular biology, including aspects related to biochemical and genetic research (not only in humans but all living beings). We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics include, but are not limited to: Advanced techniques of cellular and molecular biology (Molecular methodologies, imaging techniques, and bioinformatics); Biological activities at the molecular level; Biological processes of cell functions, cell division, senescence, maintenance, and cell death; Biomolecules interactions; Cancer; Cell biology; Chemical biology; Computational biology; Cytochemistry; Developmental biology; Disease mechanisms and therapeutics; DNA, and RNA metabolism; Gene functions, genetics, and genomics; Genetics; Immunology; Medical microbiology; Molecular biology; Molecular genetics; Molecular processes of cell and organelle dynamics; Neuroscience; Protein biosynthesis, degradation, and functions; Regulation of molecular interactions in a cell; Signalling networks and system biology; Structural biology; Virology and microbiology.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11410,editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",slug:"rosa-maria-martinez-espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",biography:"Dr. Rosa María Martínez-Espinosa has been a Spanish Full Professor since 2020 (Biochemistry and Molecular Biology) and is currently Vice-President of International Relations and Cooperation development and leader of the research group 'Applied Biochemistry” (University of Alicante, Spain). Other positions she has held at the university include Vice-Dean of Master Programs, Vice-Dean of the Degree in Biology and Vice-Dean for Mobility and Enterprise and Engagement at the Faculty of Science (University of Alicante). She received her Bachelor in Biology in 1998 (University of Alicante) and her PhD in 2003 (Biochemistry, University of Alicante). She undertook post-doctoral research at the University of East Anglia (Norwich, U.K. 2004-2005; 2007-2008).\nHer multidisciplinary research focuses on investigating archaea and their potential applications in biotechnology. She has an H-index of 21. She has authored one patent and has published more than 70 indexed papers and around 60 book chapters.\nShe has contributed to more than 150 national and international meetings during the last 15 years. Her research interests include archaea metabolism, enzymes purification and characterization, gene regulation, carotenoids and bioplastics production, antioxidant\ncompounds, waste water treatments, and brines bioremediation.\nRosa María’s other roles include editorial board member for several journals related\nto biochemistry, reviewer for more than 60 journals (biochemistry, molecular biology, biotechnology, chemistry and microbiology) and president of several organizing committees in international meetings related to the N-cycle or respiratory processes.",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null,series:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983"},editorialBoard:[{id:"79367",title:"Dr.",name:"Ana Isabel",middleName:null,surname:"Flores",slug:"ana-isabel-flores",fullName:"Ana Isabel Flores",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRpIOQA0/Profile_Picture_1632418099564",institutionString:null,institution:{name:"Hospital Universitario 12 De Octubre",institutionURL:null,country:{name:"Spain"}}},{id:"328234",title:"Ph.D.",name:"Christian",middleName:null,surname:"Palavecino",slug:"christian-palavecino",fullName:"Christian Palavecino",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000030DhEhQAK/Profile_Picture_1628835318625",institutionString:null,institution:{name:"Central University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"186585",title:"Dr.",name:"Francisco Javier",middleName:null,surname:"Martin-Romero",slug:"francisco-javier-martin-romero",fullName:"Francisco Javier Martin-Romero",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSB3HQAW/Profile_Picture_1631258137641",institutionString:null,institution:{name:"University of Extremadura",institutionURL:null,country:{name:"Spain"}}}]},onlineFirstChapters:{paginationCount:17,paginationItems:[{id:"82751",title:"Mitochondria-Endoplasmic Reticulum Interaction in Central Neurons",doi:"10.5772/intechopen.105738",signatures:"Liliya Kushnireva and Eduard Korkotian",slug:"mitochondria-endoplasmic-reticulum-interaction-in-central-neurons",totalDownloads:6,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Updates on Endoplasmic Reticulum",coverURL:"https://cdn.intechopen.com/books/images_new/11674.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"82716",title:"Advanced glycation end product induced endothelial dysfunction through ER stress: Unravelling the role of Paraoxonase 2",doi:"10.5772/intechopen.106018",signatures:"Ramya Ravi and Bharathidevi Subramaniam Rajesh",slug:"advanced-glycation-end-product-induced-endothelial-dysfunction-through-er-stress-unravelling-the-rol",totalDownloads:15,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Updates on Endoplasmic Reticulum",coverURL:"https://cdn.intechopen.com/books/images_new/11674.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"82195",title:"Endoplasmic Reticulum: A Hub in Lipid Homeostasis",doi:"10.5772/intechopen.105450",signatures:"Raúl Ventura and María Isabel Hernández-Alvarez",slug:"endoplasmic-reticulum-a-hub-in-lipid-homeostasis",totalDownloads:17,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Updates on Endoplasmic Reticulum",coverURL:"https://cdn.intechopen.com/books/images_new/11674.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"82103",title:"The Role of Endoplasmic Reticulum Stress and Its Regulation in the Progression of Neurological and Infectious Diseases",doi:"10.5772/intechopen.105543",signatures:"Mary Dover, Michael Kishek, Miranda Eddins, Naneeta Desar, Ketema Paul and Milan Fiala",slug:"the-role-of-endoplasmic-reticulum-stress-and-its-regulation-in-the-progression-of-neurological-and-i",totalDownloads:15,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Updates on Endoplasmic Reticulum",coverURL:"https://cdn.intechopen.com/books/images_new/11674.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"80954",title:"Ion Channels and Neurodegenerative Disease Aging Related",doi:"10.5772/intechopen.103074",signatures:"Marika Cordaro, Salvatore Cuzzocrea and Rosanna Di Paola",slug:"ion-channels-and-neurodegenerative-disease-aging-related",totalDownloads:12,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Ion Channels - From Basic Properties to Medical Treatment",coverURL:"https://cdn.intechopen.com/books/images_new/10838.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"81647",title:"Diabetes and Epigenetics",doi:"10.5772/intechopen.104653",signatures:"Rasha A. 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