\r\n\tCell viability is defined as the number of healthy cells in a sample and proliferation of cells is a vital indicator for understanding the mechanisms inaction of certain genes, proteins, and pathways involved in cell survival or death after exposure to toxic agents. The methods used to determine viability are also common for the detection of cell proliferation. A cell viability assay is performed based on the ratio of live and dead cells. This assay is based on an analysis of cell viability in cell culture for evaluating in vitro drug effects in cell-mediated cytotoxicity assays for monitoring cell proliferation. Various methods are involved in performing a cell viability assay, including the dilution method, surface viable count, roll tube technique, nalidixic acid method, fluorogenic dye assay, and the Trypan Blue Cell Viability Assay. The cell viability assays can determine the effect of drug candidates on cells and be used to optimize the cell culture conditions. The parameters that define cell viability can be as diverse as the redox potential of the cell population, the integrity of cell membranes, or the activity of cellular enzymes. \r\n\tCytotoxicity is the degree to which a substance can cause damage to a cell. Cytotoxicity assays measure the ability of cytotoxic compounds to cause cell damage or cell death. Cytotoxicity assays are widely used in fundamental research and drug discovery to screen libraries for toxic compounds. The cell cytotoxicity and proliferation assays are mainly used for drug screening to detect whether the test molecules have effects on cell proliferation or display direct cytotoxic effects. In a cell-based assay, it is important to know how many viable cells are remaining at the end of the experiment. There are a variety of assay methods based on various cell functions such as enzyme activity, cell membrane permeability, cell adherence, ATP production, co-enzyme production, and nucleotide uptake activity. These methods could be classified in to different categories: (I) dye exclusion methods such as trypan blue dye exclusion assay, (II) methods based on metabolic activity, (III) ATP assay, (IV) sulforhodamine B assay, (V) protease viability marker assay, (VI) clonogenic cell survival assay, (VII) DNA synthesis cell proliferation assays and (V) Raman micro-spectroscopy. \r\n\tMedical devices have been widely used in various clinical disciplines and these devices have direct contact with the tissues and cells of the body, they should have good physical and chemical properties as well as good biocompatibility. Biocompatibility testing assesses the compatibility of medical devices with a biological system. It studies the interaction between the device and the various types of living tissues and cells exposed to the device when it comes into contact with patients.
\r\n
\r\n\t \r\n\tThe book will cover original studies, reviews, all aspects of Cell Viability and Cytotoxicity assays, methods, Biocompatibility of studies of biomedical devices, and related topics.
",isbn:"978-1-80356-246-9",printIsbn:"978-1-80356-245-2",pdfIsbn:"978-1-80356-247-6",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!1,isSalesforceBook:!1,hash:"ad664980a1e5007239b6de58fcf0bd9a",bookSignature:"Prof. Sukumaran Anil",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11678.jpg",keywords:"Cytotoxicity, Cytotoxicity Testing, Biocompatibility, ATP Assay, MTT Assay, Cell Viability, DNA Synthesis Cell Proliferation Assays, Raman Micro-Spectroscopy, Trypan Blue Dye Exclusion Assay, Medical Devices, Drugs, Safety Testing",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"February 10th 2022",dateEndSecondStepPublish:"March 10th 2022",dateEndThirdStepPublish:"May 9th 2022",dateEndFourthStepPublish:"July 28th 2022",dateEndFifthStepPublish:"September 26th 2022",remainingDaysToSecondStep:"2 months",secondStepPassed:!0,currentStepOfPublishingProcess:4,editedByType:null,kuFlag:!1,biosketch:"Prof. Anil Sukumaran is currently Senior Consultant and Professor of Periodontics and Implant Dentistry, Hamad Medical Corporation/Qatar University, Doha, Qatar. He received his Ph.D. in 2002 at the University of Hong Kong. In 1995 he was the invited Researcher at the UK Centre for Oral HIV Studies, UMDS Guys Hospital, London. He is the honorary fellow of the International College of Dentists, USA, and Pierre Fauchard Academy, USA.",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"420937",title:"Prof.",name:"Sukumaran",middleName:null,surname:"Anil",slug:"sukumaran-anil",fullName:"Sukumaran Anil",profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"0",institution:null}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"19",title:"Pharmacology, Toxicology and Pharmaceutical Science",slug:"pharmacology-toxicology-and-pharmaceutical-science"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"455410",firstName:"Dajana",lastName:"Jusic",middleName:null,title:"Mrs.",imageUrl:"https://mts.intechopen.com/storage/users/455410/images/20500_n.jpeg",email:"dajana.j@intechopen.com",biography:"As an Author Service Manager my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review, to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact."}},relatedBooks:[{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"72",title:"Ionic Liquids",subtitle:"Theory, Properties, New Approaches",isOpenForSubmission:!1,hash:"d94ffa3cfa10505e3b1d676d46fcd3f5",slug:"ionic-liquids-theory-properties-new-approaches",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/72.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"314",title:"Regenerative Medicine and Tissue Engineering",subtitle:"Cells and Biomaterials",isOpenForSubmission:!1,hash:"bb67e80e480c86bb8315458012d65686",slug:"regenerative-medicine-and-tissue-engineering-cells-and-biomaterials",bookSignature:"Daniel Eberli",coverURL:"https://cdn.intechopen.com/books/images_new/314.jpg",editedByType:"Edited by",editors:[{id:"6495",title:"Dr.",name:"Daniel",surname:"Eberli",slug:"daniel-eberli",fullName:"Daniel Eberli"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"57",title:"Physics and Applications of Graphene",subtitle:"Experiments",isOpenForSubmission:!1,hash:"0e6622a71cf4f02f45bfdd5691e1189a",slug:"physics-and-applications-of-graphene-experiments",bookSignature:"Sergey Mikhailov",coverURL:"https://cdn.intechopen.com/books/images_new/57.jpg",editedByType:"Edited by",editors:[{id:"16042",title:"Dr.",name:"Sergey",surname:"Mikhailov",slug:"sergey-mikhailov",fullName:"Sergey Mikhailov"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1373",title:"Ionic Liquids",subtitle:"Applications and Perspectives",isOpenForSubmission:!1,hash:"5e9ae5ae9167cde4b344e499a792c41c",slug:"ionic-liquids-applications-and-perspectives",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/1373.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2270",title:"Fourier Transform",subtitle:"Materials Analysis",isOpenForSubmission:!1,hash:"5e094b066da527193e878e160b4772af",slug:"fourier-transform-materials-analysis",bookSignature:"Salih Mohammed Salih",coverURL:"https://cdn.intechopen.com/books/images_new/2270.jpg",editedByType:"Edited by",editors:[{id:"111691",title:"Dr.Ing.",name:"Salih",surname:"Salih",slug:"salih-salih",fullName:"Salih Salih"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"872",title:"Organic Pollutants Ten Years After the Stockholm Convention",subtitle:"Environmental and Analytical Update",isOpenForSubmission:!1,hash:"f01dc7077e1d23f3d8f5454985cafa0a",slug:"organic-pollutants-ten-years-after-the-stockholm-convention-environmental-and-analytical-update",bookSignature:"Tomasz Puzyn and Aleksandra Mostrag-Szlichtyng",coverURL:"https://cdn.intechopen.com/books/images_new/872.jpg",editedByType:"Edited by",editors:[{id:"84887",title:"Dr.",name:"Tomasz",surname:"Puzyn",slug:"tomasz-puzyn",fullName:"Tomasz Puzyn"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"40609",title:"Non-Linear Energy Harvesting with Random Noise and Multiple Harmonics",doi:"10.5772/50727",slug:"non-linear-energy-harvesting-with-random-noise-and-multiple-harmonics",body:'
1. Introduction
Harvesting energy from background mechanical vibrations in the environment has been proposed as a possible method to provide power in situations where battery usage is impractical or inconvenient. The most commonly used method for energy harvesting is to generate power from the vibrations of a piezoelectric material [1-3]; other methods include electromagnetic inductive coupling [4-6] and charge pumping across vibrating capacitive plates [7-10]. It has been shown that a piezoelectric cantilever attached to a vibrating structure can be used to power wireless transmission nodes for sensing applications [9]. In order to generate sufficient power, the frequency of the vibration source must match the resonant frequency of the piezoelectric cantilever. If the source vibrates at a fixed, known frequency, the dimensions of the cantilever, and the proof mass can be adjusted to ensure frequency matching. Many naturally occurring vibration sources do not have a fixed frequency spectrum, however, and vibrate over a broad range of frequencies. Lack of coupling of the piezoelectric cantilever to the off-resonance vibrations means that only a small amount of the available power can be harvested.
Recent reports have shown that the resonant frequency of a simply supported beam [11] or a piezoelectric cantilever [12] can be tuned by applying an axial force. Research also show that the resonant frequency of a cantilever can also be manipulated by applying a transverse force on the cantilever [13,14]. (In all these cases, the cantilevers response remained within the linear regime.) In principle, this effect could be developed into an active tuning scheme which matches the cantilever resonance to the maximum vibrational output of the environment at any particular time. Calculations indicate, however, that the power consumed by active tuning completely offsets any improvement obtained in the scavenging efficiency [15]. More promising are passive tuning schemes in which a fixed force modifies the frequency response of the cantilever beam, without requiring additional power input. For example, an attractive magnetic force acting above the cantilever beam reduces the spring constant of the cantilever and lowers the resonance frequency [13,14], while an attractive force acting along the axis of the cantilever applies axial tension, and increases the resonance frequency [12]. While this can be used to tune the resonant frequency, there is no increase in output power, and the cantilever motion can even be dampened by the magnetic force and the resulting power output reduced [12,13].
The use of a magnetic force to introduce non-linear oscillation in cantilever motion has recently been reported [16-18]. A pendulum made with piezoelectric material [16] was used to study the energy output under different strengths of random Gaussian noise. An improvement of between 400% and 600% was observed compared to a standard linear oscillator. A piezomagnetoelastic structure [17] with two external magnets was studied, in which chaotic motion was observed outside the resonance frequency. It was further reported [18] that the softening response of a cantilever due to a magnetic attractor expands the response bandwidth and also increases the off resonant amplitude significantly.
Stochastic motions have been long observed with a pendulum in a repulsive magnetic field [19-20] In a generalization effort, the optimal relationship among the physical parameters for a coupling enhancement was provided in [16] [Cottone et al., 2009] using Duffing oscillator. Improvements for the non-linear system have been attributed to an advantage in the amplification of the vibration response from energy harvesters in the stochastic regime [17-18].
Here, we will first demonstrate how this capability can be used to improve power output from a broadband vibration source, having a 1/f frequency dependence (pink noise) [21]. Note that a 1/f vibration spectrum describes a vibration source in which the power spectral density of the vibration is inversely proportional to frequency. Since many naturally occurring vibration sources display a 1/f dependence, this provides evidence that the magnetic coupling could be used for more efficient energy harvesting in practical settings.
The second part of this chapter provides an in-depth study of the response of a magnetically coupled cantilever at different frequencies [22-23]. It is our observation that amplification of the cantilever output occurs not only under stochastic motion but also due to subharmonic and ultraharmonic resonance in the vicinity of the main resonant frequency. The partial solutions of subharmonic and ultraharmonic are intrinsically embedded in the magnetic coupled equation as derived in forced oscillations of weakly nonlinear systems [24]. For a particular weakly coupled cantilever experimented in this paper, maximum output is maintained at the resonant frequency through combination of ultra-harmonic components. In a singly parametric excited scan of voltage production with non-linear piezoelectric cantilever, four distinct types of efficiency improvements are observed, in which the signal is amplified above the linear cantilever operation: (1) ultraharmonic amplification below resonance; (2) stochastic amplifications in multi-frequency and multi-amplitude oscillations; (3) ultra-sub-harmonic amplification at multiple quarter frequencies; (4) sub-harmonic amplification at one-third frequencies. For data analysis, a 1-D non-linear system coupled with piezoelectric charge production is modeled to illustrate the dynamic functions.
2. Non-linear dynamics in Pink noise background
2.1. Experimental setup and vibration backgroud
Figure 1 shows the set-up for the magnetically coupled piezoelectric cantilever measurements. The cantilever is manufactured using commercially available unimorph piezoelectric discs composed of a 0.9 mm thick PZT layer deposited on a 1 mm thick brass shim (APC International, MFT-50T-1.9A1). The disc is cut into a 13 mm wide by 50 mm long strip, and clamped at one end to produce a 44 mm long cantilever. The PZT layer extends 25 mm along the length of the cantilever, and the remainder is brass only. The proof mass (including the magnet and an additional fixture that holds the magnet) weighs 2.4 gm, while the cantilever itself weighs 0.8 gm. The electrical leads are carefully soldered with thin lead wires (134 AWP, Vishay) to the top side of the PZT and the bottom side of the shim [21].
Figure 1.
The experimental set-up for the magnetically coupled (non-linear) piezoelectric cantilever. The magnetic force is repulsive and bi-directional.
Vibration is generated by a shaker table (Labwork ET-126) driven by an amplified pink noise source (Labwork Pa-13 amplifier). The pink noise is generated numerically, with amplitude and crest factor set to -4dB and 1.41, respectively. The average shaker table acceleration is 7.5 m/s2, independent of the magnetic coupling. A custom Labview data acquisition program measures output voltage from the cantilever beam and the acceleration from the shaker table, once every second. The voltage peak to peak (Vpp) is measured by an oscilloscope (Agilent 54624A), and the dc voltage is detected with a digital multi-meter (YOGOGAWA 7561). A 5mm diameter round rare earth magnet (Radio Shack model 64-1895) is attached to the vibrating tip of the cantilever beam, while a similar opposing magnet is attached directly to the shaker table frame, with repulsive force. The distance between the magnets is adjusted to 5.5 mm, to make the magnetic force comparable to the spring force of the cantilever.
2.2. Experiment results
The voltage generated by the cantilever in response to the pink noise source is measured using three different circuits, (shown in Figures 2(a), 3(a), and 4(a)). In each case, the output from the coupled cantilever is compared with the output from the same cantilever in the uncoupled situation (with the opposing magnet removed). In Figure 2, the piezoelectric cantilever beam is wired directly to an oscilloscope with a 1 M Ohm input impedance and the peak-to-peak output voltage, Vpp is measured. As shown in Figure 2 (b) the cantilever output is seen to fluctuate as a function of time, reflecting the random nature of the vibrations. For much of the time, the output from the coupled and uncoupled cantilevers is similar. However, occasionally, very large voltage spikes are observed in the output from the coupled cantilever, that are not observed for the uncoupled case. The voltage peak to peak spans to 5.7 V (min. 0.7 V and max. 6.4 V) with the coupled setup and only 2.2 V (min. 0.9 V to max. 3 V) volts with the uncoupled cantilever. The overall RMS powers for the uncoupled cantilever are 3.95 µW and 4.85 µW for the coupled case. The ratio of the maximal voltage output from the coupled to the uncoupled is 2.1.
In Figure 3, the voltage generated by the piezoelectric cantilever beam is rectified, using 0.4 V forward biased diodes, and detected across a 22 µF capacitor and a 1 M Ohm resistor in parallel. As shown in Figure 3(b), the amplitude of the voltage output with this measurement circuit is most of the time higher in the coupled case than in the uncoupled case. This is because the RC decay time of the circuit is larger than the time between the large amplitude deflections of the cantilever. The average voltage measured across the capacitor or the voltage integration over time is approximately 50% higher in the coupled case.
Figure 2.
a) The open circuit measurement on Vpp directly from the piezoelectric cantilever, and (b) the higher swing voltage reflects the voltage generated by coupling setup with larger cantilever motions.
Figure 3.
a) The schematic of a rectified circuit with a 1 M Ohm resister, and (b) the fluctuations of the voltage indicate that more power being generated by the magnetic coupled cantilever.
In Figure 4, the rectified voltage is measured directly across the 22 µF capacitor without the 1 M Ohm resistor. As shown in Fig. 4(b), the voltage across the capacitor increases with time, until a maximum charging voltage is achieved. The maximum voltage measured across the capacitor is approximately 50% higher in the coupled case than in the uncoupled case. Note that there is a time delay for the coupled cantilever to achieve a higher voltage than the uncoupled cantilever. This is due to the time passing before the first large amplitude deflection occurs. The random nature of the motion means that this time will vary from run to run, however, on average the coupled cantilever output will be consistently higher than the uncoupled output. Note that in addition to producing more power, the higher voltage output enables circuit operation without a step-up transformer, eliminating the power loss in the transformer.
Figure 4.
a) The schematic of the storage circuit, and (b) DC voltage output measured on the storage capacitor indicating more charge is stored with the magnetic coupling setup.
2.3. Discussion
It is instructive to compare the force exerted on the cantilever in the coupled and uncoupled cases. To do this, an empirical measure of the magnetic force is obtained using the experimental set-up shown in Figure 5.
Figure 5.
The magnetic force component function, Fz, is determined by the electronic scale versus the manual deflection of the cantilever.
The opposing magnet is mounted onto a measurement scale, and the position of the magnetized cantilever is manipulated by pushing up and down at the end of a cantilever beam, simulating flexure movement. The deflection z is measured using a micrometer, while the reading on the scale provides the force between the two magnets. The details of the force measurments were shown in [22]. Only the magnetic force in the z direction, Fz, contributes to the resultant spring force. At z=0, the force is zero in the z direction because the two magnetic forces only repel each other in the longitudinal direction. Fz increases as the angles between the two magnets increase until the overlap between the two magnets is zero. At this point, Fz decreases with increasing distance because the force is inversely proportional to the distance squared.
The spring force, the magnetic force and the resultant force (spring plus magnetic) are plotted in Figure 6,
Figure 6.
The plot shows the magnitude of the magnetic forces exerted on the cantilever beam, the spring forces and the resultant forces.
The resultant force is significantly reduced compared to the bare spring force near z=0. The coupled system has three equilibrium points where the resultant force is zero, compared to the single equilibrium point of the bare spring force. Because the resultant force in the region of the three equilibrium points is relatively small, transitions between the three points occurs relatively easily. Note that the middle equilibrium is unstable, therefore when the piezoelectric cantilever is set up for the coupling experiment, the cantilever is off the equilibrium point toward ground in static state as shown in Figure 1. In Figure 7 the potential energy is plotted for both the uncoupled and coupled systems. The potential energy is calculated by direct integration of the force with respect to the displacement, z. This gives for the uncoupled case, and for the coupled case. For the coupled case, the resultant potential is raised, with two local minima symmetric to z=0. This double well structure allows easy movement of the cantilever beam even when excited by non resonant forces. Once it passes the local high potential, it drifts to the other side of the balance, resulting in an increased total deflection distance. This can be seen by considering the possible motion of the cantilever beam having a kinetic energy, h, which is large enough to surmount the potential barrier at z=0. With the same random acceleration background the coupled cantilever can travel further distance than the uncoupled one. The voltage output, which depends on the movement of the cantilever, therefore, increases. The ratio of the maximum displacement in the coupled and uncoupled systems determined from Figure 7 is 2.4. This is comparable to the ratio of maximum voltage output in the coupled and uncoupled systems, which was seen in Figure 2 (b), at 2.1.
Figure 7.
The direct integration from the measured forces function in Fig. 6 leads to the magnetic potential, spring potential and the resultant spring potential. The responding range in the coupled and the uncoupled cantilever is defined by the same potential height, h.
The magnetic coupling (although a passive force requiring no energy) introduces a symmetric force which acts in the opposite direction to the spring force around z=0. Being comparable in magnitude to the spring force, the magnetic force compensates the spring potential, and introduces a double valley in the potential energy profile. Under the influence of the modified spring potential, the magnetically coupled cantilever responds to a random vibration source (like the pink noise) by moving chaotically between the two minima in the potential energy profile. As compared with the non-chaotic motion of the uncoupled cantilever around the single z=0 potential minimum, this produces larger cantilever deflection and more voltage output from the piezoelectric cantilever. The oscillations around the resonance frequency are unstable and chaotic, but persistent. The modified spring potential is higher, and flatter than the bare spring potential, making the magnetic coupled cantilever easier to excite in the random frequency region. The experiments show that the ratio of the open circuit peak to peak voltage output and the potential well are closely related. Future work includes the design and implementation of modified potential wells and further analysis of the gain due to the modified potential wells.
3. Resonance broadening in broad band spectrum
3.1. Experiment setup
The experiment set up is the same as Figure 1. In all measurements, the shaker table acceleration is set to approximately 4.2 m/s2 at resonant freqeuncy, and the frequency swept from 0 to 30 Hz in 0.5 Hz steps. The opposing magnet fitted at the free end of the cantilever supplies a symmetrical, repulsive force about the balance of the cantilever during vibration. The horizontal separation between the magnets (designated by ) is adjusted to be approximately between 6 to 6.5 mm. This separation is found to provide the best compensation for the spring force, and makes the effective restoring force as small as possible near the equilibrium point.
3.2. Experiment result with open circuit
Figure 8 shows both the output of the piezoelectric cantilever as a function of shaker table vibration frequency for the linear and non-linear case. The voltage generated by the piezoelectric cantilever beam is directed measured by oscilloscope treated as an open circuit. At the resonance frequency (measured to be 9.5 Hz) the output of the cantilever was 53 V, and the peak height, resonance frequency and line width are all approximately the same for the linear and non-linear states (here linear refers to the non-coupled state, while non-linear refers to the magnetically coupled state). On either side of the main resonance, however, there is additional output observed for the non-linear cantilever, which is not observed in the linear state. As can be seen from a comparison of the linear and the non-linear runs, the overall amplitude profile of the non-linear run is much larger in the sense of a broadband distribution, although there are gaps between peaks in the overall pattern of the non-linear output.
Figure 9 shows the output of both the linear and non-liner cantilever measured as a function of time at selected frequency to illustrate the comparison of the linear and non-linear dynamics. The voltage output of the non-linear cantilever evolves with frequency, while being amplified close to the resonance frequency. The spectrum shows a variety of amplified motions and harmonics. For example, at a driving frequency as low as 6.5 Hz (between 6-7.5Hz) (Figure 9(a)) both the linear and non-linear cantilever motions follow the vibrations of the shaker table, producing periodic oscillations. The amplitude of the oscillations for the non-linear cantilever is 5 times larger than those for the linear cantilever, however. At the resonant frequency (Figure 9(b)) both linear and non-linear cantilevers oscillate at the driving frequency with equal amplitudes. At 13 Hz (Figure 9(c)) the linear cantilever motion continues to follow the vibrations of the shaker table, producing low amplitude periodic oscillations. The non-linear cantilever motion is aperiodic and has a magnitude which is on average 3 times larger than that of the linear cantilever. At 16 Hz (Figure 9 (d)) the non-linear cantilever produces a 3 times larger peak to peak amplitude than the linear cantilever, and shows multiple and periodic “half-way” vibrations. At 20Hz (Figure 9 (e)) the non-linear cantilever shows a 5 times larger amplitude at the frequency of 6.7Hz than the linear output at 20 Hz.
Figure 8.
The voltage output (peak to peak) of the piezoelectric cantilever measured as a function of frequency (dash line for linear and solid line for non-linear state).
Note should be taken that there are two unexpected small peaks at 12.5 Hz and 17 Hz for the linear response. The peaks at 12.5 Hz and 17 Hz on the experiment data come from the torsion and standing wave oscillations. It is the result of how the piezoelectric cantilever was facilitated with magnet and its fixture as the proof mass. The cantilever is relatively thin and droops naturally due the weight of proof mass a few millimeters (as shown in Figure 1) to a curve. The L-shape fixture that holds the magnet was bolted with a screw on one side parallel to the brass shim. The magnet is then attached on the other side of the L-shape fixture, perpendicular to the brass shim in such way to make magnetic coupling. During the process, the cantilever was deformed and twisted slightly. As a result, the combined proof mass is slightly located off the center of the cantilever beam resulting in weight imbalance and torsion mode resonance. The fixture also creates an area where the free end is rigid with the fixture, which acts like a semi-fixed end, paving a way for a standing wave vibration when the cantilever is excited. Finite Element Analysis (FEA) simulating the structure and dimensions confirms that the first 3 modes of vibration include bending, torsion and standing wave oscillations.
Figure 9.
The output of the linear (dash line) and non-linear (solid) system in the time domain: (a) 6.5 Hz (b) 9.5Hz at resonance; (c) 13 Hz ; (d) 16Hz ;(e) 20Hz
3.3. Theoretical simulations
The dynamics of the piezoelectric cantilever is modeled by a 1-D driven spring-mass system coupled with the piezoelectric effect under the influence of a magnetic force Fm(z) [17-18]:
mz¨+dz˙+kz+Fm(z)+σV=mA(ω)cos(ωt),E1
\n\t\t\t\t
with mass m=0.0024 kg, damping coefficient d=0.0075 kg/sec, spring constant k=8.55 N/m, and angular frequency ω. Here, z is the vertical deflection of the cantilever, V is the generated voltage, σ=5x10-6 N/V is the coupling coefficient, and A is the acceleration of the shaker table (A=4.2 m/sec2 measured at resonance frequency). The voltage output is related to the deflection of the piezoelectric cantilever through:
V˙+1RlClV+θz˙=0E2
where Rl is the equivalent resistance, Cl is the equivalent capacitance and 1/ (Rl Cl)= 0.01, and θ=1250 is the piezoelectric coupling coefficient in the measured circuit. The transverse magnetic force (in the z direction) is determined from the force between two magnetic dipoles (Kraftmakher, 2007):
Fm(z,η)=−3u0M2a(bz)(4η2−(bz)2)4π((bz)2+η2)72E3
\n\t\t\t\t
where M is the dipole magnetization, u0 is the permeability in air, and η is the horizontal separation between the magnets at z=0. The correction factors a and b are included to compensate for the flexure motion of cantilever and the magnetic force along the cantilever axis [16]. The magnetization M is determined by direct measurement of the axial force between the cantilever and a fixed magnet using a reference scale [22].
The solution to the coupled differential equations (1) and (2) is determined using Maple software to give the voltage output versus time for a given driving frequency, magnetic force function, and separation η. In order to fit our experiment data, the magnetic force Fm(z) was modified by a and b parameters and used for our calculation, where M = 0.011Am2, η = 6.5 mm, a = 1.04 and b = 1.21. As in the experiment, the output is calculated for t = 0 to 10 seconds, and the maximum peak-to-peak output over the last 2 seconds obtained. The result of the frequency domain is showed in Figure 10, which resembles the experimental result as seen in Figure 8.
Both the experiment and simulation figures show broadband vibration for the non-linear configuration between 6-20Hz. The simulation in Figures 11(a)-(e) reproduces many of the features observed in the experiment in Figures 9(a)-(e). The rest of Figures 11-15 reveals more about the complexity of the multiple harmonics in the non-linear systems. The simulations of the time domain with the corresponding frequency selected from experiment are shown in Figures 11(a)-15(a). Figures 11(b)-15(b) illustrate the velocity vs. voltage output of the piezoelectric cantilever in both the linear and non-linear cases. Figures 11(c)-15(c) are the Fourier transform of the coupled cantilever cases in Figures 11(a)-15(a), respectively, showing the compositions of frequency components for the non-linear states. The following section will discuss the multiple harmonic components directly derived from the non-linear dynamics simulations.
Figure 10.
The simulated voltage output (peak to peak) of the piezoelectric cantilever is plotted in the frequency domain (dash line for linear and solid line non-linear).
3.4. Multiple harmonics analysis
At a driving frequency of 6.5 Hz, as seen in Figure 11(a), both the linear and non-linear cantilever motion follow the vibrations of the shaker table, producing periodic oscillations. The amplitude of the oscillations for the coupled cantilever, however, is approximately 5 times larger than those for the linear cantilever, as seen in the experiment in Figure 9(a). The velocity vs. voltage in Figure 11(b) shows that the coupled cantilever has non-linear component in voltage production. Further analysis through Fourier transformation indicates that the non-linear cantilever shows the combination of the excited 6.5 Hz harmonic (dominant and high amplitude) and the 20 Hz ultraharmonic (3 times the excited frequency), as seen in Figure 11(c).
At the resonant frequency of 9.5 Hz (Figure 12(a)) both non-linear and linear cantilevers oscillate at the driving frequency with equal amplitude of voltage output. The responses for both the coupled and uncoupled cantilever at resonant frequency are almost identical in the voltage output. The velocity vs. voltage in Figure 12(b) shows a little non-linearity at 90o and -90o of the vibration cycles. Through Fourier transformation as seen in Figure 12(c), the non-linear cantilever shows some components of vibration at the excited 9.5 Hz harmonic (dominant) and the 29 Hz ultraharmonic (3 times the excited frequency).
Figure 11.
The theoretical analysis of excited frequency at 6.5 Hz. (a) the time domain voltage output, dash line for linear and solid line for non-linear states; (b) the velocity vs. voltage output, dark line for linear and light line for non-linear state; (c) the Fourier transform of the non-linear state from the data of Figure 5(a).
Figure 12.
The theoretical analysis of excited frequency at 9.5 Hz. (a) the time domain voltage output, dash line for linear and solid line for non-linear state; (b) the velocity vs. voltage output, light line for linear and dark line for non-linear state; (c) the Fourier transform of the non-linear state from the data of Figure 12(a).
The response for the non-linear cantilever is chaotic at 13 Hz as seen in Figure 13(a), but with average 3 folds larger magnitude than the linear one. The velocity vs. voltage relation in Figure 13(b) shows chaotic motions for the coupled cantilever. Using Fourier transformation for Figure 13(a) results in Figure 13(c), the coupled cantilever shows the linear response of a small portion of 13 Hz component combined with a large amplitude distribution at lower frequency that are attributed to the chaotic motion. Note that the small peaks at 12.5 Hz and 17 Hz are not observed in the simulation as seen and discussed in the experiment section. This small torsion and standing wave bending resonance are not accounted for by the simplified 1-D model used to simulate the spring mass damping model such as an ideal cantilever.
At 16Hz, the non-linear cantilever is periodic (Figure 14(a)) and is 3 times larger (peak to peak) in magnitude than the uncoupled one, with double prone of low frequency in the upper cycle. Apparently, it is and composed of different frequency and multiple haromonic motion, with large magnitude than the uncoupled motion. The evidence is also shown in the velocity vs. voltage relationship in Figure 14(b), where 3 different cyclic loops are identifiable. Fourier transformation from time data in Figure 14(a) proves that the non-linear cantilever delivers ultra-sub-harmonic vibration at n*(16/4) Hz, where, n=integer in Figure 14(c).
Figure 13.
The theoretical analysis of excited frequency at 13 Hz. (a) the time domain voltage output, dash line for linear and solid line for non-linear states; (b) the velocity vs. voltage output, light line for linear and dark line for non-linear state; (c) the Fourier transform of the non-linear state from the data of Figure 13(a).
Figure 14.
The theoretical analysis of excited frequency at 16 Hz. (a) the time domain voltage output, dash line for linear and solid line for non-linear states; (b) the velocity vs. voltage output, light line for linear and dark line for non-linear state; (c) the Fourier transform of the non-linear state from the data of Figure 14(a).
At 20Hz, the response for the non-linear cantilever is periodic and also 3 folds larger peak to peak magnitude than the linear one as seen in Figure 15 (a). The velocity vs. voltage in Figure 15(b) shows some combination of cyclic motions for the non-linear cantilever. Through Fourier transformation, the coupled cantilever shows subharmonic at 6.7 Hz (dominant), excite frequency/3, and 20 Hz in Figure 15(c).
The combination of the stochastic and various harmonic features have three to five folds greater voltage production than the linear standard narrow band piezoelectric cantilever. Together with the un-damped resonant response enhance the performance well beyond that of a standard energy harvester.
Figure 15.
The theoretical analysis of excited frequency at 20 Hz. (a) the time domain voltage output, dash line for linear and solid line for non-linear states; (b) the velocity vs. voltage output, light line for linear and dark line for non-linear state; (c) the Fourier transform of the non-linear state from the data of Figure 15(a).
3.5. Experience result with storage capacitor
Figure 16 (a) shows the output of the other PZT cantilever with similar specs as a function of shaker table vibration frequency for the case where the opposing magnet is fixed to the shaker table. The voltage generated by the piezoelectric cantilever beam is rectified, and detected across a 22 µF capacitor and 1 M Ohm resistor in parallel, using the circuit shown in Figure 3 (a). The results from two measurement runs in the coupled state are shown, together with the output of the cantilever measured in the uncoupled state. (This is obtained by removing the opposing magnet.) At the resonance frequency, (measured to be approximately 10 Hz) the output of the cantilever exceeds 16 V, and the peak height, resonance frequency and linewidth are all approximately the same for the coupled and un-coupled states. On either side of the main resonance, however, there are additional output observed for the coupled cantilever, which is not observed in the uncoupled state. As can be seen from a comparison of the two coupled runs, the frequency distribution of the peaks are the result of the multiple harmonics, as predicted in the open circuit.
Figure 16.
Voltage output of the piezoelectric cantilever as a function of shaker table frequency for (a) single cantilever (b) double cantilever. Integrated voltage output as a function of frequency for (c) single cantilever and (d) double cantilever.
Also measured was a double cantilever system, (as shown in Fig. 16(b)), in which the second magnet is connected to an opposing cantilever (having resonant frequency of around 60Hz) rather than to a fixed point. As shown in Fig. 16 (b), the results are similar to the single cantilever system, except that the double cantilever system shows a larger overall increase in off-resonance output. The overall improvement in the harvesting efficiency can be illustrated by plotting the integrated voltage output of the cantilever beam as a function of frequency. For both the single (Fig. 16 (c)) and double (Fig. 16 (d)) cantilever systems, the integrated voltage output over the 0-30 Hz bandwidth shows a substantial increase in the coupled versus the uncoupled case. The total improvement is 31%-87%, with some variation between measurement runs.
4. Conclusion
Piezoelectric cantilevers have been widely studied for energy scavenging applications, but suffer from poor output power outside of a narrow frequency range near the cantilever resonance. In this chapter, we have demonstrated how power output can be enhanced by applying a simple passive external force. When a symmetrical and repulsive magnetic force is applied to a piezoelectric cantilever beam to compensate the cantilever spring force, this lowers the spring potential and increases the output when driven by a random pink noise vibrational source. The principle may be applied to other vibration energy harvesting devices such as electromagnetic and capacitive types in random naturally pink noise environments.
In the parametrically excited piezoelectric cantilever experiments, linear and non-linear performances were compared. Overall, four distinct types of efficiency improvements appear in the non-linear configuration, in which the signal is amplified above the linear cantilever response: low frequency ultraharmonic amplification; stochastic amplifications in multi-frequency and multi-amplitude oscillations; ultra-sub-harmonic amplification at multiple quarter frequencies; subharmonic amplification at one-third frequencies. Taken together, the stochastic, sub-harmonic and ultra-harmonic response produces an average of three to five-fold increase in voltage production. For energy harvesting purposes, the combination of the four features together with the un-damped resonant response enhances the performance well beyond that of a standard energy harvester. Furthermore, an analytical model of the bi-stable dynamics produces results consistent with those observed experimentally. The simulation tool could be deployed in the future investigation for non-linear energy harvester design for broadband and beyond natural harmonic applications.
Acknowledgement
The effort was funded by the Department Of Energy DE-FC26-06NT42795 and the U.S. Navy under Contract DAAB07-03-D-B010/TO-0198. Technical program oversight under the Navy contract was provided by Naval Surface Warfare Center, Crane Division.
\n',keywords:null,chapterPDFUrl:"https://cdn.intechopen.com/pdfs/40609.pdf",chapterXML:"https://mts.intechopen.com/source/xml/40609.xml",downloadPdfUrl:"/chapter/pdf-download/40609",previewPdfUrl:"/chapter/pdf-preview/40609",totalDownloads:2996,totalViews:181,totalCrossrefCites:0,totalDimensionsCites:0,totalAltmetricsMentions:0,impactScore:0,impactScorePercentile:15,impactScoreQuartile:1,hasAltmetrics:0,dateSubmitted:"December 15th 2011",dateReviewed:"June 18th 2012",datePrePublished:null,datePublished:"October 31st 2012",dateFinished:"October 29th 2012",readingETA:"0",abstract:null,reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/40609",risUrl:"/chapter/ris/40609",book:{id:"2706",slug:"small-scale-energy-harvesting"},signatures:"Ji-Tzuoh Lin, Barclay Lee and Bruce William Alphenaar",authors:[{id:"50069",title:"Dr.",name:"Ji-Tzuoh",middleName:null,surname:"Lin",fullName:"Ji-Tzuoh Lin",slug:"ji-tzuoh-lin",email:"j0lin001@louisville.edu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"University of Louisville",institutionURL:null,country:{name:"United States of America"}}},{id:"160837",title:"Prof.",name:"Bruce",middleName:null,surname:"Alphenaar",fullName:"Bruce Alphenaar",slug:"bruce-alphenaar",email:"bwalph01@louisville.edu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"160838",title:"Mr.",name:"Barclay",middleName:null,surname:"Lee",fullName:"Barclay Lee",slug:"barclay-lee",email:"hatoblue@gmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Non-linear dynamics in Pink noise background ",level:"1"},{id:"sec_2_2",title:"2.1. Experimental setup and vibration backgroud",level:"2"},{id:"sec_3_2",title:"2.2. Experiment results",level:"2"},{id:"sec_4_2",title:"2.3. Discussion",level:"2"},{id:"sec_6",title:"3. Resonance broadening in broad band spectrum",level:"1"},{id:"sec_6_2",title:"3.1. Experiment setup",level:"2"},{id:"sec_7_2",title:"3.2. Experiment result with open circuit",level:"2"},{id:"sec_8_2",title:"3.3. Theoretical simulations",level:"2"},{id:"sec_9_2",title:"3.4. Multiple harmonics analysis",level:"2"},{id:"sec_10_2",title:"3.5. Experience result with storage capacitor",level:"2"},{id:"sec_12",title:"4. Conclusion",level:"1"},{id:"sec_13",title:"Acknowledgement",level:"1"}],chapterReferences:[{id:"B1",body:'ElvinN. G.ElvinA.ChoiD.2003A self-powered damage detection sensor J. Strain Anal. Eng. Des. 38115\n\t\t\t'},{id:"B2",body:'OttmanG. K.HofmannH. F.LesieutreG. A.2003Optimized piezoelectric energy harvesting circuit using step-down converter in discontinuous conduction mode IEEE Trans. Power Electron. 18696\n\t\t\t'},{id:"B3",body:'RoundyS.2004A piezoelectric vibration based generator for wireless electronics, Smart Mater. Struct. 13 1131\n\t\t\t'},{id:"B4",body:'KulahH.NajafiK.2004An electromagnetic micro power generator for low-frequency environmental vibrations, 17th IEEE Int. conf. Micro Electro Mechanical System, 1004 (MEMS ‘04) 237240\n\t\t\t'},{id:"B5",body:'vonBüren. T.TrösterG.Designoptimizationof. a.linearvibration-driven.electromagneticmicro-power.generatorSens.Actuators A 13520072007765775\n\t\t\t'},{id:"B6",body:'BeebyS. P.TorahR. N.TudorM. J.Glynne-JonesP.O’DonnellT.SahaC. R.RoyS.microA.electromagneticgenerator.forvibration.energyharvesting. J.Micromech. Microeng. 172007200712571265\n\t\t\t'},{id:"B7",body:'Hsi-wenLo.Yu-ChongTai.Parylene-basedelectret.powergenerators. J.Micromech. Microeng. 1820082008104006104014\n\t\t\t'},{id:"B8",body:'SterkenT.FioriniP.BaertK.PuersR.BorghsG.Anelectret-base.electrostaticmicro-generator.transducersThe.12thInternational.Conferenceon.SolidState.SensorsActuators.MicrosystemsBoston, June 6-12, 200312911294\n\t\t\t'},{id:"B9",body:'ShadRoundy.PaulKenneth.WrightJanM.Rabaey, Energy scavenging for Wireless Sensor Networks with Special Focus on Vibrations, Kluwer Academic Publishers, 2004'},{id:"B10",body:'ChiuY.TsengV. F. G.capacitiveA.vibrationto.electricityenergy.converterwith.integratedmechanical.switchesJ.Micromech. Microeng. 18 (20081010104004\n\t\t\t'},{id:"B11",body:'EliS.LelandPaulK.WrightResonance.tuningof.piezoelectricvibration.energyscavenging.generatorsusing.compressiveaxial.preloadSmart Mater. Struct.152006200614131420\n\t\t\t'},{id:"B12",body:'DibinZhu.StephenRoberts.MichaelJ.TudorStephenP.BeebyClosed.LoopFrequency.Tuningof. a.Vibration-BasedMicrogenerator.Proceedingsof.PowerM. E. M. S.2008/microE. M.microEMS2008, November 2008\n\t\t\t'},{id:"B13",body:'VinodR.ChallaM. G.PrasadYong.ShiFrankT.FisherA.vibrationenergy.harvestingdevice.withbidirectional.resonancefrequency.tunnablitySmart Mater. Struct.17 12008'},{id:"B14",body:'Ji-Tzuoh Lin, Walter Jones, Bruce Alphenaar, Yang Xu and Deirdre Alphenaar.Passive magnetic coupling for enhanced piezoelectric cantilever response for energy scavenging applications. 17th International Symposium on Applications of Ferroelectrics (ISAF 2008EH017) Feb 2427\n\t\t\t'},{id:"B15",body:'Shad Roundy and Yang Zhang, Toward self-tuning adaptive vibration-based microgenerator, Proceedings of SPIE Volume 5649 Smart Structure, Devices and System II February2005373384\n\t\t\t'},{id:"B16",body:'CottoneF.VoccaH.GammaitonL.Non-linearEnergy.HarvestingPhysical.ReviewLetter,10.2009'},{id:"B17",body:'A. Erturk, J. Hoffmann, D. J. Inman, A piezomagnetoleastic structure for broadband vibration energy harvesting, Applied Physics Letter, 94 254102 2009'},{id:"B18",body:'Samuel C. Staton, Clark C. Mcgehee, Brian P. Mann, Reversible hysteresis for broadband magnetopiezoelastic energy harvesting, Applied Physics Letter, 95, 174103 2009'},{id:"B19",body:'DuchesneB.FischerC. W.GrayC. G.JeffreyK. R.“.Chaos In The Motion of An Inverted Pendulum: An Undergraduate Laboratory Experiment,” Am. J. Phys. 1991'},{id:"B20",body:'SiahmakounA.FrenchV. A.PattersonJ.“.Nonlinear Dynamics of A Sinusoidally Driven Pendulum In a Propulsive Magnetic Field,” Am. J. Phys. 1997\n\t\t\t'},{id:"B21",body:'Ji-Tzuoh Lin and Bruce Alphenaar.Enhancement of Energy Harvested from a Random Vibration Source by Magnetic Coupling of a Piezoelectric Cantilever,” Journal of Intelligent Material Systems and Structures, 20102113\n\t\t\t'},{id:"B22",body:'Ji-Tzuoh Lin, Barclay Lee, and Bruce Alphenaar.Magnetic Coupling of Piezoelectric Cantilever for Enhanced Energy Harvesting Efficiency” Smart Mater. Struct. 2010'},{id:"B23",body:'Ji-Tzuoh Lin, Kevin Walsh and Bruce Alphenaar.Enhanced Stochastic, Subharmonic and Ultraharmonic Energy Harvesting, Journal of Intelligent Material and Structure Systems, ( accepted May 4th on line) 2012'},{id:"B24",body:'A.Prosperetti “Subharmonics and Ultraharmonics in The Forced Oscillations of Weakly Nonlinear Systems.” American Journal of Physics 4461976'},{id:"B25",body:'KraftmakherY.magnetic Field of A Dipole And the Dipole-Dipole Interaction,” Eur. J. Phys. 2007\n\t\t\t'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Ji-Tzuoh Lin",address:null,affiliation:'
'},{corresp:null,contributorFullName:"Bruce William Alphenaar",address:null,affiliation:'
'}],corrections:null},book:{id:"2706",type:"book",title:"Small-Scale Energy Harvesting",subtitle:null,fullTitle:"Small-Scale Energy Harvesting",slug:"small-scale-energy-harvesting",publishedDate:"October 31st 2012",bookSignature:"Mickael Lallart",coverURL:"https://cdn.intechopen.com/books/images_new/2706.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:null,printIsbn:"978-953-51-0826-9",pdfIsbn:"978-953-51-4267-6",reviewType:"peer-reviewed",numberOfWosCitations:163,isAvailableForWebshopOrdering:!0,editors:[{id:"10041",title:"Dr.",name:"Mickaël",middleName:null,surname:"Lallart",slug:"mickael-lallart",fullName:"Mickaël Lallart"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"771"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},chapters:[{id:"40608",type:"chapter",title:"Advances in Photoelectrochemical Fuel Cell Research",slug:"advances-in-photoelectrochemical-fuel-cell-research",totalDownloads:4515,totalCrossrefCites:2,signatures:"Kai Ren and Yong X. Gan",reviewType:"peer-reviewed",authors:[{id:"15216",title:"Dr.",name:"Yong",middleName:"Xue",surname:"Gan",fullName:"Yong Gan",slug:"yong-gan"},{id:"148095",title:"Mr.",name:"Kai",middleName:null,surname:"Ren",fullName:"Kai Ren",slug:"kai-ren"}]},{id:"40611",type:"chapter",title:"Three Dimensional TCAD Simulation of a Thermoelectric Module Suitable for Use in a Thermoelectric Energy Harvesting System",slug:"three-dimensional-tcad-simulation-of-a-thermoelectric-module-suitable-for-use-in-a-thermoelectric-en",totalDownloads:4236,totalCrossrefCites:3,signatures:"Chris Gould and Noel Shammas",reviewType:"peer-reviewed",authors:[{id:"3552",title:"Dr.",name:"Chris",middleName:null,surname:"Gould",fullName:"Chris Gould",slug:"chris-gould"},{id:"134025",title:"Prof.",name:"Noel",middleName:null,surname:"Shammas",fullName:"Noel Shammas",slug:"noel-shammas"}]},{id:"40606",type:"chapter",title:"Thermal Energy Harvesting Using Fluorinated Terpolymers",slug:"thermal-energy-harvesting-using-fluorinated-terpolymers",totalDownloads:3233,totalCrossrefCites:0,signatures:"Hongying Zhu, Sébastien Pruvost, Pierre-Jean Cottinet and Daniel Guyomar",reviewType:"peer-reviewed",authors:[{id:"10042",title:"Prof.",name:"Daniel",middleName:"Jean",surname:"Guyomar",fullName:"Daniel Guyomar",slug:"daniel-guyomar"},{id:"12401",title:"Dr.",name:"Pierre-Jean",middleName:null,surname:"Cottinet",fullName:"Pierre-Jean Cottinet",slug:"pierre-jean-cottinet"},{id:"144210",title:"Dr.",name:"Hongying",middleName:null,surname:"Zhu",fullName:"Hongying Zhu",slug:"hongying-zhu"},{id:"144211",title:"Dr.",name:"Sébastien",middleName:null,surname:"Pruvost",fullName:"Sébastien Pruvost",slug:"sebastien-pruvost"}]},{id:"40610",type:"chapter",title:"High Energy Density Capacitance Microgenerators",slug:"high-energy-density-capacitance-microgenerators",totalDownloads:2109,totalCrossrefCites:0,signatures:"Igor L. Baginsky and Edward G. Kostsov",reviewType:"peer-reviewed",authors:[{id:"28620",title:"Dr.",name:"Igor",middleName:"Leonidovich",surname:"Baginsky",fullName:"Igor Baginsky",slug:"igor-baginsky"},{id:"29271",title:"Prof.",name:"Edward G.",middleName:"Genadievich",surname:"Kostsov",fullName:"Edward G. Kostsov",slug:"edward-g.-kostsov"}]},{id:"40640",type:"chapter",title:"Electrostatic Conversion for Vibration Energy Harvesting",slug:"electrostatic-conversion-for-vibration-energy-harvesting",totalDownloads:4850,totalCrossrefCites:94,signatures:"S. Boisseau, G. Despesse and B. Ahmed Seddik",reviewType:"peer-reviewed",authors:[{id:"139151",title:"Dr.",name:"Ghislain",middleName:null,surname:"Despesse",fullName:"Ghislain Despesse",slug:"ghislain-despesse"},{id:"164277",title:"Dr.",name:"Sebastien",middleName:null,surname:"Boisseau",fullName:"Sebastien Boisseau",slug:"sebastien-boisseau"},{id:"164439",title:"Mr.",name:"Bouhadjar",middleName:null,surname:"Ahmed Seddik",fullName:"Bouhadjar Ahmed Seddik",slug:"bouhadjar-ahmed-seddik"}]},{id:"40613",type:"chapter",title:"Piezoelectric MEMS Power Generators for Vibration Energy Harvesting",slug:"piezoelectric-mems-power-generators-for-vibration-energy-harvesting",totalDownloads:5852,totalCrossrefCites:1,signatures:"Wen Jong Wu and Bor Shiun Lee",reviewType:"peer-reviewed",authors:[{id:"139526",title:"Prof.",name:"Wen-Jong",middleName:null,surname:"Wu",fullName:"Wen-Jong Wu",slug:"wen-jong-wu"}]},{id:"40607",type:"chapter",title:"Wideband Electromagnetic Energy Harvesting from a Rotating Wheel",slug:"wideband-electromagnetic-energy-harvesting-from-a-rotating-wheel",totalDownloads:5618,totalCrossrefCites:4,signatures:"Yu-Jen Wang, Sheng-Chih Shen and Chung-De Chen",reviewType:"peer-reviewed",authors:[{id:"143719",title:"Dr.",name:"Yu-Jen",middleName:null,surname:"Wang",fullName:"Yu-Jen Wang",slug:"yu-jen-wang"},{id:"158998",title:"Prof.",name:"Sheng Chih",middleName:null,surname:"Shen",fullName:"Sheng Chih Shen",slug:"sheng-chih-shen"}]},{id:"40642",type:"chapter",title:"Electrostrictive Polymers for Vibration Energy Harvesting",slug:"electrostrictive-polymers-for-vibration-energy-harvesting",totalDownloads:3357,totalCrossrefCites:1,signatures:"Mickaël Lallart, Pierre-Jean Cottinet, Jean-Fabien Capsal, Laurent Lebrun and Daniel Guyomar",reviewType:"peer-reviewed",authors:[{id:"10041",title:"Dr.",name:"Mickaël",middleName:null,surname:"Lallart",fullName:"Mickaël Lallart",slug:"mickael-lallart"},{id:"10042",title:"Prof.",name:"Daniel",middleName:"Jean",surname:"Guyomar",fullName:"Daniel Guyomar",slug:"daniel-guyomar"},{id:"12401",title:"Dr.",name:"Pierre-Jean",middleName:null,surname:"Cottinet",fullName:"Pierre-Jean Cottinet",slug:"pierre-jean-cottinet"},{id:"12571",title:"Pr.",name:"Laurent",middleName:null,surname:"Lebrun",fullName:"Laurent Lebrun",slug:"laurent-lebrun"},{id:"145265",title:"Dr.",name:"Jean-Fabien",middleName:null,surname:"Capsal",fullName:"Jean-Fabien Capsal",slug:"jean-fabien-capsal"}]},{id:"40615",type:"chapter",title:"Analysis of Energy Harvesting Using Frequency Up-Conversion by Analytic Approximations",slug:"analysis-of-energy-harvesting-using-frequency-up-conversion-by-analytic-approximations",totalDownloads:2474,totalCrossrefCites:2,signatures:"Adam Wickenheiser",reviewType:"peer-reviewed",authors:[{id:"95222",title:"Prof.",name:"Adam",middleName:null,surname:"Wickenheiser",fullName:"Adam Wickenheiser",slug:"adam-wickenheiser"}]},{id:"40612",type:"chapter",title:"Strategies for Wideband Mechanical Energy Harvester",slug:"strategies-for-wideband-mechanical-energy-harvester",totalDownloads:2885,totalCrossrefCites:2,signatures:"B. Ahmed Seddik, G. Despesse, S. Boisseau and E. Defay",reviewType:"peer-reviewed",authors:[{id:"139151",title:"Dr.",name:"Ghislain",middleName:null,surname:"Despesse",fullName:"Ghislain Despesse",slug:"ghislain-despesse"},{id:"164277",title:"Dr.",name:"Sebastien",middleName:null,surname:"Boisseau",fullName:"Sebastien Boisseau",slug:"sebastien-boisseau"},{id:"164439",title:"Mr.",name:"Bouhadjar",middleName:null,surname:"Ahmed Seddik",fullName:"Bouhadjar Ahmed Seddik",slug:"bouhadjar-ahmed-seddik"},{id:"165359",title:"Dr.",name:"Emmanuel",middleName:null,surname:"Defay",fullName:"Emmanuel Defay",slug:"emmanuel-defay"}]},{id:"40614",type:"chapter",title:"Microscale Energy Harvesters with Nonlinearities Due to Internal Impacts",slug:"microscale-energy-harvesters-with-nonlinearities-due-to-internal-impacts",totalDownloads:2569,totalCrossrefCites:0,signatures:"Cuong Phu Le and Einar Halvorsen",reviewType:"peer-reviewed",authors:[{id:"136905",title:"Prof.",name:"Einar",middleName:null,surname:"Halvorsen",fullName:"Einar Halvorsen",slug:"einar-halvorsen"},{id:"165266",title:"MSc.",name:"Cuong Phu",middleName:null,surname:"Le",fullName:"Cuong Phu Le",slug:"cuong-phu-le"}]},{id:"40609",type:"chapter",title:"Non-Linear Energy Harvesting with Random Noise and Multiple Harmonics",slug:"non-linear-energy-harvesting-with-random-noise-and-multiple-harmonics",totalDownloads:2996,totalCrossrefCites:0,signatures:"Ji-Tzuoh Lin, Barclay Lee and Bruce William Alphenaar",reviewType:"peer-reviewed",authors:[{id:"50069",title:"Dr.",name:"Ji-Tzuoh",middleName:null,surname:"Lin",fullName:"Ji-Tzuoh Lin",slug:"ji-tzuoh-lin"},{id:"160837",title:"Prof.",name:"Bruce",middleName:null,surname:"Alphenaar",fullName:"Bruce Alphenaar",slug:"bruce-alphenaar"},{id:"160838",title:"Mr.",name:"Barclay",middleName:null,surname:"Lee",fullName:"Barclay Lee",slug:"barclay-lee"}]},{id:"40643",type:"chapter",title:"Modeling Aspects of Nonlinear Energy Harvesting for Increased Bandwidth",slug:"modeling-aspects-of-nonlinear-energy-harvesting-for-increased-bandwidth",totalDownloads:2876,totalCrossrefCites:1,signatures:"Marcus Neubauer, Jens Twiefel, Henrik Westermann and Jörg Wallaschek",reviewType:"peer-reviewed",authors:[{id:"47918",title:"Dr.",name:"Marcus",middleName:null,surname:"Neubauer",fullName:"Marcus Neubauer",slug:"marcus-neubauer"},{id:"148040",title:"MSc.",name:"Henrik",middleName:null,surname:"Westermann",fullName:"Henrik Westermann",slug:"henrik-westermann"},{id:"165348",title:"Dr.",name:"Jens",middleName:null,surname:"Twiefel",fullName:"Jens Twiefel",slug:"jens-twiefel"},{id:"165349",title:"Prof.",name:"Jörg",middleName:null,surname:"Wallaschek",fullName:"Jörg Wallaschek",slug:"jorg-wallaschek"}]},{id:"40638",type:"chapter",title:"Self-Powered Electronics for Piezoelectric Energy Harvesting Devices",slug:"self-powered-electronics-for-piezoelectric-energy-harvesting-devices",totalDownloads:4498,totalCrossrefCites:6,signatures:"Yuan-Ping Liu and Dejan Vasic",reviewType:"peer-reviewed",authors:[{id:"150107",title:"Dr.",name:"Dejan",middleName:null,surname:"Vasic",fullName:"Dejan Vasic",slug:"dejan-vasic"},{id:"150108",title:"Dr.",name:"Yuan-Ping",middleName:null,surname:"Liu",fullName:"Yuan-Ping Liu",slug:"yuan-ping-liu"}]}]},relatedBooks:[{type:"book",id:"424",title:"Ferroelectrics",subtitle:"Physical Effects",isOpenForSubmission:!1,hash:"d9d8a531dfb92ccd58e2a8b9a426dcd4",slug:"ferroelectrics-physical-effects",bookSignature:"Mickaël Lallart",coverURL:"https://cdn.intechopen.com/books/images_new/424.jpg",editedByType:"Edited by",editors:[{id:"10041",title:"Dr.",name:"Mickaël",surname:"Lallart",slug:"mickael-lallart",fullName:"Mickaël Lallart"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"},chapters:[{id:"16747",title:"Morphotropic Phase Boundary in Ferroelectric Materials",slug:"morphotropic-phase-boundary-in-ferroelectric-materials",signatures:"Abdel-Baset M. A. Ibrahim, Rajan Murgan, Mohd Kamil Abd Rahman and Junaidah Osman",authors:[{id:"14762",title:"Dr.",name:"Mohd Kamil",middleName:null,surname:"Abd Rahman",fullName:"Mohd Kamil Abd Rahman",slug:"mohd-kamil-abd-rahman"},{id:"357554",title:"Dr.",name:"Rajan",middleName:null,surname:"Murgan",fullName:"Rajan Murgan",slug:"rajan-murgan"},{id:"357555",title:"Dr.",name:"Junaidah",middleName:null,surname:"Osman",fullName:"Junaidah Osman",slug:"junaidah-osman"},{id:"471248",title:"Dr.",name:"Abdel-Baset",middleName:"M. A.",surname:"Ibrahim",fullName:"Abdel-Baset Ibrahim",slug:"abdel-baset-ibrahim"}]},{id:"16748",title:"Relaxor-ferroelectric PMN–PT Thick Films",slug:"relaxor-ferroelectric-pmn-pt-thick-films",signatures:"Hana Uršič and Marija Kosec",authors:[{id:"25116",title:"Prof.",name:"Marija",middleName:null,surname:"Kosec",fullName:"Marija Kosec",slug:"marija-kosec"},{id:"32811",title:"Dr.",name:"Hana",middleName:null,surname:"Uršič",fullName:"Hana Uršič",slug:"hana-ursic"}]},{id:"16749",title:"Phase Diagramm, Cristallization Behavior and Ferroelectric Properties of Stoichiometric Glass Ceramics in the BaO-TiO2-B2O3 System",slug:"phase-diagramm-cristallization-behavior-and-ferroelectric-properties-of-stoichiometric-glass-ceramic",signatures:"Rafael Hovhannisyan, Hovakim Alexanyan, Martun Hovhannisyan, Berta Petrosyan and Vardan Harutyunyan",authors:[{id:"29831",title:"Dr.",name:"Rafael",middleName:"Mkhitar",surname:"Hovhannisyan",fullName:"Rafael Hovhannisyan",slug:"rafael-hovhannisyan"},{id:"37702",title:"Mr.",name:"Martun",middleName:null,surname:"Hovhannisyan",fullName:"Martun Hovhannisyan",slug:"martun-hovhannisyan"},{id:"357723",title:"Dr.",name:"Hovakim",middleName:null,surname:"Alexanyan",fullName:"Hovakim Alexanyan",slug:"hovakim-alexanyan"},{id:"357724",title:"Dr.",name:"Berta",middleName:null,surname:"Petrosyan",fullName:"Berta Petrosyan",slug:"berta-petrosyan"},{id:"357725",title:"Dr.",name:"Vardan",middleName:null,surname:"Harutyunyan",fullName:"Vardan Harutyunyan",slug:"vardan-harutyunyan"}]},{id:"16750",title:"Ferroelectric Properties and Polarization Switching Kinetic of Poly (vinylidene fluoride-trifluoroethylene) Copolymer",slug:"ferroelectric-properties-and-polarization-switching-kinetic-of-poly-vinylidene-fluoride-trifluoroeth",signatures:"Duo Mao, Bruce E. Gnade and Manuel A. Quevedo-Lopez",authors:[{id:"27411",title:"Prof.",name:"Manuel",middleName:null,surname:"Quevedo-Lopez",fullName:"Manuel Quevedo-Lopez",slug:"manuel-quevedo-lopez"},{id:"42809",title:"Dr.",name:"Duo",middleName:null,surname:"Mao",fullName:"Duo Mao",slug:"duo-mao"},{id:"357726",title:"Dr.",name:"Bruce E.",middleName:null,surname:"Gnade",fullName:"Bruce E. Gnade",slug:"bruce-e.-gnade"}]},{id:"16751",title:"Charge Transport in Ferroelectric Thin Films",slug:"charge-transport-in-ferroelectric-thin-films",signatures:"Lucian Pintilie",authors:[{id:"21029",title:"Dr.",name:"Lucian",middleName:null,surname:"Pintilie",fullName:"Lucian Pintilie",slug:"lucian-pintilie"}]},{id:"16752",title:"Hydrogen in Ferroelectrics",slug:"hydrogen-in-ferroelectrics",signatures:"Hai-You Huang, Yan-Jing Su and Li-Jie Qiao",authors:[{id:"27367",title:"Dr.",name:null,middleName:null,surname:"Chu",fullName:"Chu",slug:"chu"},{id:"29711",title:"Dr.",name:"Hai-You",middleName:null,surname:"Huang",fullName:"Hai-You Huang",slug:"hai-you-huang"},{id:"363979",title:"Dr.",name:"Yan-Jing",middleName:null,surname:"Su",fullName:"Yan-Jing Su",slug:"yan-jing-su"},{id:"363980",title:"Dr.",name:"Li-Jie",middleName:null,surname:"Qiao",fullName:"Li-Jie Qiao",slug:"li-jie-qiao"}]},{id:"16753",title:"Thermal Conduction Across Ferroelectric Phase Transitions: Results on Selected Systems",slug:"thermal-conduction-across-ferroelectric-phase-transitions-results-on-selected-systems",signatures:"Jacob Philip",authors:[{id:"30551",title:"Prof.",name:"Jacob",middleName:null,surname:"Philip",fullName:"Jacob Philip",slug:"jacob-philip"}]},{id:"16754",title:"The Induced Antiferroelectric Phase - Structural Correlations",slug:"the-induced-antiferroelectric-phase-structural-correlations",signatures:"Marzena Tykarska",authors:[{id:"30717",title:"Dr.",name:null,middleName:null,surname:"Tykarska",fullName:"Tykarska",slug:"tykarska"}]},{id:"19311",title:"Piezoelectric Effect in Rochelle Salt",slug:"piezoelectric-effect-in-rochelle-salt",signatures:"Andriy Andrusyk",authors:[{id:"26871",title:"Dr.",name:"Andriy",middleName:null,surname:"Andrusyk",fullName:"Andriy Andrusyk",slug:"andriy-andrusyk"}]},{id:"16756",title:"Piezoelectricity in Lead-Zirconate-Titanate Ceramics – Extrinsic and Intrinsic Contributions",slug:"piezoelectricity-in-lead-zirconate-titanate-ceramics-extrinsic-and-intrinsic-contributions",signatures:"Johannes Frantti and Yukari Fujioka",authors:[{id:"30737",title:"Dr.",name:"Johannes",middleName:null,surname:"Frantti",fullName:"Johannes Frantti",slug:"johannes-frantti"},{id:"38455",title:"Dr.",name:"Yukari",middleName:null,surname:"Fujioka",fullName:"Yukari Fujioka",slug:"yukari-fujioka"}]},{id:"16757",title:"B-site Multi-element Doping Effect on Electrical Property of Bismuth Titanate Ceramics",slug:"b-site-multi-element-doping-effect-on-electrical-property-of-bismuth-titanate-ceramics",signatures:"Jungang Hou and R. V. Kumar",authors:[{id:"38542",title:"Dr.",name:"R Vasant",middleName:null,surname:"Kumar",fullName:"R Vasant Kumar",slug:"r-vasant-kumar"},{id:"39267",title:"Dr.",name:"J. G.",middleName:null,surname:"Hou",fullName:"J. G. Hou",slug:"j.-g.-hou"}]},{id:"16758",title:"Magnetoelectric Multiferroic Composites",slug:"magnetoelectric-multiferroic-composites",signatures:"M. I. Bichurin, V. M. Petrov and S.Priya",authors:[{id:"25001",title:"Prof.",name:"Mirza",middleName:"Imamovich",surname:"Bichurin",fullName:"Mirza Bichurin",slug:"mirza-bichurin"},{id:"32581",title:"Prof.",name:"Shashank",middleName:null,surname:"Priya",fullName:"Shashank Priya",slug:"shashank-priya"},{id:"36824",title:"Prof.",name:"Vladimir",middleName:null,surname:"Petrov",fullName:"Vladimir Petrov",slug:"vladimir-petrov"}]},{id:"16759",title:"Coupling Between Spins and Phonons Towards Ferroelectricity in Magnetoelectric Systems",slug:"coupling-between-spins-and-phonons-towards-ferroelectricity-in-magnetoelectric-systems",signatures:"J. Agostinho Moreira and A. Almeida",authors:[{id:"25735",title:"Dr.",name:"J",middleName:"Agustinho",surname:"Moreira",fullName:"J Moreira",slug:"j-moreira"}]},{id:"16760",title:"Ferroelectric Field Effect Control of Magnetism in Multiferroic Heterostructures",slug:"ferroelectric-field-effect-control-of-magnetism-in-multiferroic-heterostructures",signatures:"Carlos A. F. Vaz and Charles H. Ahn",authors:[{id:"38784",title:"Dr.",name:"Carlos",middleName:null,surname:"Vaz",fullName:"Carlos Vaz",slug:"carlos-vaz"}]},{id:"16761",title:"Effects of Doping and Oxygen Nonstoichiometry on the Thermodynamic Properties of Some Multiferroic Ceramics",slug:"effects-of-doping-and-oxygen-nonstoichiometry-on-the-thermodynamic-properties-of-some-multiferroic-c",signatures:"Speranta Tanasescu, Alina Botea and Adelina Ianculescu",authors:[{id:"24934",title:"Dr.",name:"Speranta",middleName:null,surname:"Tanasescu",fullName:"Speranta Tanasescu",slug:"speranta-tanasescu"},{id:"130531",title:"Prof.",name:"Adelina",middleName:null,surname:"Ianculescu",fullName:"Adelina Ianculescu",slug:"adelina-ianculescu"},{id:"363981",title:"Dr.",name:"Alina",middleName:null,surname:"Botea1",fullName:"Alina Botea1",slug:"alina-botea1"}]},{id:"16762",title:"Multifunctional Characteristics of B-site Substituted BiFeO3 Films",slug:"multifunctional-characteristics-of-b-site-substituted-bifeo3-films",signatures:"Hiroshi Naganuma",authors:[{id:"28619",title:"Prof.",name:"Hiroshi",middleName:null,surname:"Naganuma",fullName:"Hiroshi Naganuma",slug:"hiroshi-naganuma"}]},{id:"16763",title:"Ferroelectric Liquid Crystals with High Spontaneous Polarization",slug:"ferroelectric-liquid-crystals-with-high-spontaneous-polarization",signatures:"Slavomír Pirkl and Milada Glogarova",authors:[{id:"34659",title:"Prof.",name:"Slavomir",middleName:null,surname:"Pirkl",fullName:"Slavomir Pirkl",slug:"slavomir-pirkl"},{id:"38077",title:"Dr.",name:"Milada",middleName:null,surname:"Glogarova",fullName:"Milada Glogarova",slug:"milada-glogarova"}]},{id:"16764",title:"Ferroelectric Liquid Crystals Composed of Banana-Shaped Thioesters",slug:"ferroelectric-liquid-crystals-composed-of-banana-shaped-thioesters",signatures:"Stanisław Wróbel, Janusz Chruściel, Marta Wierzejska-Adamowicz, Monika Marzec, Danuta M. Ossowska-Chruściel, Christian Legrand and Redouane Douali",authors:[{id:"46525",title:"Prof.",name:"Stanislaw",middleName:null,surname:"Wróbel",fullName:"Stanislaw Wróbel",slug:"stanislaw-wrobel"},{id:"48104",title:"Dr.",name:"Marta",middleName:null,surname:"Wierzejska-Adamowicz",fullName:"Marta Wierzejska-Adamowicz",slug:"marta-wierzejska-adamowicz"},{id:"48105",title:"MSc",name:"Jan",middleName:"Marcin",surname:"Czerwiec",fullName:"Jan Czerwiec",slug:"jan-czerwiec"},{id:"48106",title:"Dr.",name:"Monika",middleName:null,surname:"Marzec",fullName:"Monika Marzec",slug:"monika-marzec"},{id:"48107",title:"Prof.",name:"Janusz",middleName:null,surname:"Chrusciel",fullName:"Janusz Chrusciel",slug:"janusz-chrusciel"},{id:"48108",title:"Dr.",name:"Danuta",middleName:null,surname:"Ossowska-Chrusciel",fullName:"Danuta Ossowska-Chrusciel",slug:"danuta-ossowska-chrusciel"},{id:"48109",title:"Dr.",name:"Redouane",middleName:null,surname:"Douali",fullName:"Redouane Douali",slug:"redouane-douali"},{id:"48110",title:"Prof.",name:"Christian",middleName:null,surname:"Legrand",fullName:"Christian Legrand",slug:"christian-legrand"}]},{id:"16765",title:"Molecular Design of a Chiral Oligomer for Stabilizing a Ferrielectric Phase",slug:"molecular-design-of-a-chiral-oligomer-for-stabilizing-a-ferrielectric-phase",signatures:"Atsushi Yoshizawa and Anna Noji",authors:[{id:"42967",title:"Prof.",name:"Atsushi",middleName:null,surname:"Yoshizawa",fullName:"Atsushi Yoshizawa",slug:"atsushi-yoshizawa"},{id:"87046",title:"Ms.",name:"Anna",middleName:null,surname:"Noji",fullName:"Anna Noji",slug:"anna-noji"}]},{id:"16766",title:"Memory Effects in Mixtures of Liquid Crystals and Anisotropic Nanoparticles",slug:"memory-effects-in-mixtures-of-liquid-crystals-and-anisotropic-nanoparticles",signatures:"Marjan Krašna, Matej Cvetko, Milan Ambrožič and Samo Kralj",authors:[{id:"47441",title:"Dr.",name:"Marjan",middleName:null,surname:"Krašna",fullName:"Marjan Krašna",slug:"marjan-krasna"},{id:"47446",title:"Dr.",name:"Matej",middleName:null,surname:"Cveto",fullName:"Matej Cveto",slug:"matej-cveto"},{id:"47447",title:"Dr.",name:"Milan",middleName:null,surname:"Ambrozic",fullName:"Milan Ambrozic",slug:"milan-ambrozic"},{id:"177727",title:"Dr.",name:"Samo",middleName:null,surname:"Kralj",fullName:"Samo Kralj",slug:"samo-kralj"}]},{id:"16767",title:"Photorefractive Ferroelectric Liquid Crystals",slug:"photorefractive-ferroelectric-liquid-crystals",signatures:"Takeo Sasaki",authors:[{id:"26788",title:"Prof.",name:"Takeo",middleName:null,surname:"Sasaki",fullName:"Takeo Sasaki",slug:"takeo-sasaki"}]},{id:"16768",title:"Linear and Nonlinear Optical Properties of Ferroelectric Thin Films",slug:"linear-and-nonlinear-optical-properties-of-ferroelectric-thin-films",signatures:"Bing Gu and Hui-Tian Wang",authors:[{id:"25451",title:"Prof.",name:"Bing",middleName:null,surname:"Gu",fullName:"Bing Gu",slug:"bing-gu"},{id:"27896",title:"Prof.",name:"Hui-Tian",middleName:null,surname:"wang",fullName:"Hui-Tian wang",slug:"hui-tian-wang"}]},{id:"16769",title:"Localized States in Narrow-Gap Ferroelectric-Semiconductor PbSnTe: Injection Currents, IR and THz Photosensitivity, Magnetic Field Effects",slug:"localized-states-in-narrow-gap-ferroelectric-semiconductor-pbsnte-injection-currents-ir-and-thz-phot",signatures:"Alexander Klimov and Vladimir Shumsky",authors:[{id:"29491",title:"Dr.",name:"Alexander",middleName:null,surname:"Klimov",fullName:"Alexander Klimov",slug:"alexander-klimov"},{id:"29501",title:"Dr.",name:"Vladimir",middleName:null,surname:"Shumsky",fullName:"Vladimir Shumsky",slug:"vladimir-shumsky"}]},{id:"16770",title:"Piezo-optic and Dielectric Behavior of the Ferroelectric Lithium Heptagermanate Crystals",slug:"piezo-optic-and-dielectric-behavior-of-the-ferroelectric-lithium-heptagermanate-crystals",signatures:"A. K. Bain, Prem Chand and K. Veerabhadra Rao",authors:[{id:"25044",title:"Dr.",name:"Ashim",middleName:"Kumar",surname:"Bain",fullName:"Ashim Bain",slug:"ashim-bain"},{id:"31754",title:"Dr.",name:"Prem",middleName:null,surname:"Chand",fullName:"Prem Chand",slug:"prem-chand"},{id:"31755",title:"Dr.",name:"K.Veerabhadra",middleName:null,surname:"Rao",fullName:"K.Veerabhadra Rao",slug:"k.veerabhadra-rao"}]},{id:"16771",title:"Compositional and Optical Gradient in Films of PbZrxTi1-xO3 (PZT) Family",slug:"compositional-and-optical-gradient-in-films-of-pbzrxti1-xo3-pzt-family",signatures:"Ilze Aulika, Alexandr Dejneka, Silvana Mergan, Marco Crepaldi, Lubomir Jastrabik, Qi Zhang, Andreja Benčan, Maria Kosec and Vismants Zauls",authors:[{id:"27354",title:"Dr.",name:"Ilze",middleName:null,surname:"Aulika",fullName:"Ilze Aulika",slug:"ilze-aulika"},{id:"29564",title:"Dr.",name:"Andreja",middleName:null,surname:"Bencan",fullName:"Andreja Bencan",slug:"andreja-bencan"},{id:"37063",title:"Dr.",name:"Alexandr",middleName:null,surname:"Dejneka",fullName:"Alexandr Dejneka",slug:"alexandr-dejneka"},{id:"364296",title:"Dr.",name:"Mergan",middleName:null,surname:"Silvana",fullName:"Mergan Silvana",slug:"mergan-silvana"},{id:"364297",title:"Dr.",name:"Crepaldi",middleName:null,surname:"Marco",fullName:"Crepaldi Marco",slug:"crepaldi-marco"},{id:"364298",title:"Dr.",name:"Jastrabik",middleName:null,surname:"Lubomir",fullName:"Jastrabik Lubomir",slug:"jastrabik-lubomir"},{id:"364299",title:"Dr.",name:"Kosec",middleName:null,surname:"Maria",fullName:"Kosec Maria",slug:"kosec-maria"},{id:"364300",title:"Dr.",name:"Zauls",middleName:null,surname:"Vismants",fullName:"Zauls Vismants",slug:"zauls-vismants"}]},{id:"16772",title:"Photo-induced Effect in Quantum Paraelectric Materials Studied by Transient Birefringence Measurement",slug:"photo-induced-effect-in-quantum-paraelectric-materials-studied-by-transient-birefringence-measuremen",signatures:"Toshiro Kohmoto and Yuka Koyama",authors:[{id:"27366",title:"Prof.",name:"Toshiro",middleName:null,surname:"Kohmoto",fullName:"Toshiro Kohmoto",slug:"toshiro-kohmoto"},{id:"38550",title:"Dr.",name:"Yaka",middleName:null,surname:"Koyama",fullName:"Yaka Koyama",slug:"yaka-koyama"}]},{id:"16773",title:"Photoluminescence in Doped PZT Ferroelectric Ceramic System",slug:"photoluminescence-in-doped-pzt-ferroelectric-ceramic-system",signatures:"M. D. Durruthy-Rodríguez and J. M. Yáñez-Limón",authors:[{id:"44226",title:"Dr.",name:"Maria",middleName:"Dolores",surname:"Durruthy-Rodríguez",fullName:"Maria Durruthy-Rodríguez",slug:"maria-durruthy-rodriguez"},{id:"357727",title:"Dr.",name:"J. M.",middleName:null,surname:"Yáñez-Limón",fullName:"J. M. Yáñez-Limón",slug:"j.-m.-yanez-limon"}]},{id:"16774",title:"Photovoltaic Effect in Ferroelectric LiNbO3 Single Crystal",slug:"photovoltaic-effect-in-ferroelectric-linbo3-single-crystal",signatures:"Zhiqing Lu, Kun Zhao and Xiaoming Li",authors:[{id:"27553",title:"Prof.",name:"Kun",middleName:null,surname:"Zhao",fullName:"Kun Zhao",slug:"kun-zhao"},{id:"34794",title:"Dr.",name:"Zhiqing",middleName:null,surname:"Lu",fullName:"Zhiqing Lu",slug:"zhiqing-lu"},{id:"34798",title:"Mr.",name:"Xiaoming",middleName:null,surname:"Li",fullName:"Xiaoming Li",slug:"xiaoming-li"}]}]}],publishedBooks:[{type:"book",id:"115",title:"Wind Turbines",subtitle:null,isOpenForSubmission:!1,hash:null,slug:"wind-turbines",bookSignature:"Ibrahim Al-Bahadly",coverURL:"https://cdn.intechopen.com/books/images_new/115.jpg",editedByType:"Edited by",editors:[{id:"19588",title:"Dr.",name:"Ibrahim H.",surname:"Al-Bahadly",slug:"ibrahim-h.-al-bahadly",fullName:"Ibrahim H. Al-Bahadly"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"148",title:"Wind Farm",subtitle:"Technical Regulations, Potential Estimation and Siting Assessment",isOpenForSubmission:!1,hash:"f7a3aafd9530aba9911c69ec17d31673",slug:"wind-farm-technical-regulations-potential-estimation-and-siting-assessment",bookSignature:"Gastón O. Suvire",coverURL:"https://cdn.intechopen.com/books/images_new/148.jpg",editedByType:"Edited by",editors:[{id:"12698",title:"Dr.",name:"Gastón Orlando",surname:"Suvire",slug:"gaston-orlando-suvire",fullName:"Gastón Orlando Suvire"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"205",title:"Fundamental and Advanced Topics in Wind Power",subtitle:null,isOpenForSubmission:!1,hash:"b8b5955addb75d98a6bba1c94e3e7a74",slug:"fundamental-and-advanced-topics-in-wind-power",bookSignature:"Rupp Carriveau",coverURL:"https://cdn.intechopen.com/books/images_new/205.jpg",editedByType:"Edited by",editors:[{id:"22234",title:"Dr.",name:"Rupp",surname:"Carriveau",slug:"rupp-carriveau",fullName:"Rupp Carriveau"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"212",title:"Energy Storage in the Emerging Era of Smart Grids",subtitle:null,isOpenForSubmission:!1,hash:"8cd6021285906516c727802d02ce0954",slug:"energy-storage-in-the-emerging-era-of-smart-grids",bookSignature:"Rosario Carbone",coverURL:"https://cdn.intechopen.com/books/images_new/212.jpg",editedByType:"Edited by",editors:[{id:"11592",title:"Prof.",name:"Rosario",surname:"Carbone",slug:"rosario-carbone",fullName:"Rosario Carbone"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"214",title:"Energy Management Systems",subtitle:null,isOpenForSubmission:!1,hash:"a7d93a7487829da3eb86b2e819720536",slug:"energy-management-systems",bookSignature:"P. Giridhar Kini",coverURL:"https://cdn.intechopen.com/books/images_new/214.jpg",editedByType:"Edited by",editors:[{id:"42436",title:"Dr.",name:"Giridhar",surname:"Kini",slug:"giridhar-kini",fullName:"Giridhar Kini"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],publishedBooksByAuthor:[{type:"book",id:"391",title:"Modern Telemetry",subtitle:null,isOpenForSubmission:!1,hash:"75ba8bf1dfa8263596d85270dd3c4691",slug:"modern-telemetry",bookSignature:"Ondrej Krejcar",coverURL:"https://cdn.intechopen.com/books/images_new/391.jpg",editedByType:"Edited by",editors:[{id:"1111",title:"Dr.",name:"Ondrej",surname:"Krejcar",slug:"ondrej-krejcar",fullName:"Ondrej Krejcar"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2706",title:"Small-Scale Energy Harvesting",subtitle:null,isOpenForSubmission:!1,hash:"63bc4c27bdf9ec1e00aa20ff6f1d804f",slug:"small-scale-energy-harvesting",bookSignature:"Mickael Lallart",coverURL:"https://cdn.intechopen.com/books/images_new/2706.jpg",editedByType:"Edited by",editors:[{id:"10041",title:"Dr.",name:"Mickaël",surname:"Lallart",slug:"mickael-lallart",fullName:"Mickaël Lallart"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},onlineFirst:{chapter:{type:"chapter",id:"78427",title:"Pathogenicity Mechanism of Candida albicans",doi:"10.5772/intechopen.99737",slug:"pathogenicity-mechanism-of-em-candida-albicans-em-",body:'
1. Introduction
Candida is a diploid parasite that as often as possible causes mucosal and fundamental contaminations in people [1]. Candida species can colonize a few particular anatomical locales. Greater part of diseases by commensal microorganisms comes from endogenous colonization. Notwithstanding, exogenous pollution, for example, diseases communicated through emergency clinic workers, medical clinic air, and biofilm-debased intrusive gadgets like catheters, can likewise happen [2, 3, 4]. Diseases brought about by Candida can be delegated shallow, cutaneous, mucosal, and fundamental infection. At the point when Candida spp. taint the oral cavity, skin, genitalia, respiratory framework, and the remainder of the gastrointestinal lot, the disease is delegated the shallow sort. Intrusive candidiasis is a disease portrayed with very extreme conditions, for example, candidemia, meningitis (influencing the mind), and endocarditis (influencing the heart) [5]. In hospitalized patients and those with bedraggled safe framework, intrusive contamination is a huge reason for dismalness and mortality along with increased frequency as well as pervasiveness rates.
Candida species pathogenesis is a complex cycle including numerous instruments and pathways. It is likewise a mind boggling and multifactorial system, including highlights of both the host and the microorganism [6]. For contamination to be set up, the pioneering microorganism should avoid, duplicate in the host climate, and make do in the safe arrangement of the host. The living being must likewise have the option to scatter to other body tissues and organs, most particularly in foundational disease [7]. Problem in skin or gastrointestinal boundaries can prompt dispersed or profound organ candidiasis. In more significant circumstances, circulatory system intrusion may some time possible which hence will disperse to various organs of the body.
Candida contaminations in a great many people are asymptomatic. This is because of the capacity of the immunological framework to checkmate the life form as it endeavors to spread in the body. In any case, consumption in resistant systemor changes in microbiota balance, combined with different elements, can work with the spread of Candida which is regularly deadly in 42% of announced cases [8, 9, 10]. C. albicans is answerable for about half of candidiasis and non-albicans Candida species are liable for the rest of the Candida contamination. Disease brought about by several other species of candida are of extraordinary concern. A portion of these non-albicans Candida species are presently viewed as arising artful microbes [11]. Forestalling Candida contaminations for the most part brought about by Candida species is a developing test in human medication. Indeed, even with the accessibility and utilization of antifungal prescription, scattered candidiasis is went with high death rate (around 40–60%), helpless conclusion, and unseemly illness the board. The overall clinical show of the patient likewise adds to the expansion in death rate. Protection from antifungal medications is not, at this point another issue. Indeed, even among people that have not been presented to anti-infection agents, obstruction has been accounted for [12]. Candida is one of the main sources of mucosal contaminations in sound people for now days. It additionally causes initial diseases particularly in immunosuppressive patients, regardless of its status as a commensal microorganism [13]. Truth be told, candidiasis is viewed as the third to fourth most regular infection in medical care offices inside the USA and even all around the world [14].
As anyone might expect, it is the destructiveness and pathogenic qualities and components that have gotten the most consideration from specialists throughout the long term. As of late, much have been found out about the components of Candida pathogenesis. Studies have shown that at the core of the capacity of Candida to multiply, change from non-destructiveness commensal to pioneering pathogenic organism and build up disease in the host lie profoundly interconnected elements made out of transcriptional circuits, morphology-related/harmfulness encoding qualities, metabolic versatility, genome pliancy, phenotypic exchanging, biofilm arrangement, tissue harming extracellular hydrolytic catalysts, and a few different variables that work with destructiveness and pathogenesis in Candida species [15]. Changes in ecological pH, vigorous supplement procurement framework, escape from phagocytosis, avoidance from have insusceptible framework, have microbiome coaggregation, protection from antifungal specialists, and the capacity to productively react to numerous anxieties are other crucial characteristics that upgrade endurance and pathogenesis.
In order to be capable of inducing such a diversity of infections C. albicans can live in several anatomically discrete sites and translates several virulence factors. The phenomenon of phenotypic converting from yeast- to filament-growth is just one, but critical, factor that contributes to the virulence of C. albicans. It offers a basis for activating different receptors leading to diverse immune responses. Other virulence factors of C. albicans contain adhesion factors, thigmotropism and secretion of several hydrolytic enzymes, such as lipase, phospholipase, and proteinase. During the past few years it has become increasingly clear that PRRs are vital for the host response to C. albicans, with various TLRs and LRs having distinctive roles in innate immunity. Each ligand–receptor system activates specific intracellular signaling pathways, which in turn leads to modulation of various components of the host immune response. While a few receptors, like TLR4, dectin 1 and the MR, apply an all the more favorable to fiery job, others employ immunosuppressive impacts (for instance, TLR2, CR3 and FcγR). After disclosure and characterized clarification of the part of TLRs in parasitic acknowledgment, further investigations have explained the job of the C-type lectin receptors with an emphasis basically on dectin-1 and dectin-2. The presence of various relationships among all of the components that guide the establishment of pollutions is an undeniable component in the pathogenesis of Candida species. This chapter is precisely based on the mechanisms of Candida pathogenesis with emphasis on the virulence factors mostly the important receptors and pathogenic determinants.
2. Pathogenicity mechanism of Candida species
2.1 Infection
The pathogenicity of C. albicans is identified with its change between the commensal yeast structure and the obtrusive hyphal shape [16]. Upon have cell connection, thigmotropism (contact detecting) triggers C. albicans filamentation. This allows the creature to infiltrate further into the host tissues through extracellular compound emission [17]. The capacity of Candida to change over from yeast to hyphae stage or hyphae to yeast stage is named dimorphism. Every one of these periods of development is crucial for harmfulness and pathogenicity as it impacts how Candida gets away from the resistant framework. Yeast and fiber (hyphae) structures assume autonomous parts during scattered candidiasis. While the yeast structures engaged with scattering, the hyphal (filamentous) structure is associated with tissue intrusion and pathogenesis [18]. Candida species should have the option to adequately colonize its host and moreover adjust to assortments of unessential requirements like temperature, oxygen, pH, carbon dioxide, and diverse negative organic conditions, for example, carbon source, supplement accessibility, the immunological framework, and other existing together bacterial and contagious cells inside the specialty [19, 20]. Positive reaction to those imperatives has a quick impact in transformation and advancement of Candida harmfulness and pathogenicity. Before receptor-intervened epithelial acknowledgment by Candida species, a few flagging pathways are actuated. Temperature change, supplement starvation, oxidative pressure, osmotic pressure, and pH detecting trigger mitogen-enacted protein kinase, pathways based on CAMP, transduction of Rim-101, along with surprisingly hereditary mechanisms that constantly instigate numerous qualities. Most of the induced characteristics are connected with filamentous turn of events and biofilm plan. While assorted hereditary pathways transduce shifts from yeast to hyphae or hyphae to yeast stage, distinctive ecological signals emphatically and contrarily regulate morphology-related cell surface exchanging [21]. The flagging and variation pathways assume pivotal parts in different physiological and cell measures engaged with the Candida species pathogenicity as demonstrated in Table 1.
Involved in sensing and transmitting stress signals and other environmental signals
Three main MAP kinase pathways are the following:
Mkc1- controls cellular integrity, invasive growth, cell wall biogenesis, and formation of biofilm
Hog1- mediates response to thermal, osmotic, and oxidative stress. Controls cell wall formationand morphogenesis. Under osmotic stress, its activation leads to glycerol accumulation.
Cek1- it mediates mating and hyphae formation and is also involved in adaptation to boththermal and nutrient stresses.
ERG3 and ERG11 play major roles in azole drug resistance; thus, it is the target of fluconazoleantifungals
6
Genome plasticity
Triggers adaptation to fluctuating host environment. Leads to the generation of recombinant progeny with increased fitness. Induces natural mutations that alter the balance between commensalism and pathogenicity.
Triggers polarized filamentous growth Involved in the generation/evolution of new pathotypes or strains Enhances the utilization of several nutrients. Facilitates Candida growth rate, as well as its morphology and behaviors at the host interface
Major pathogenicity inducing pathways/responses in Candida species.
The greater part of the flagging pathways are amazingly fundamental for protecting Candida spp. against immunological assault [40]. They assume different parts in the declaration of morphology related qualities. The co-articulation of morphology-connected proteins brings about synergistic association among quality items fundamental for biofilm foundation and development inside the host [41]. Along these lines, for hindering Candida endurance in have tissues, impedance with Candida species capacity to incorporate quality articulation to changes in morphology could be surely a potential restorative technique [42]. Also, distinguishing flagging segments saved among Candida species is vital for recognizing potential medication targets. During the interaction of pathogenesis, actuated endocytosis happens. It for the most part happens inside 4 h of starting contact to epithelial cell. Candida uses prompted endocytosis to sidestep invulnerable acknowledgment. The acknowledgment of invasins communicated on the contagious cell surface triggers prompted endocytosis. Until this point, only A1s3p and Ssa1p (invasins) are known for C. albicans. In a murine model of oropharyngeal candidiasis revealed by Sun et al., Als3 and Ssa1 freaks displayed diminished grip and intrusion of cells of epithelium [43]. Free of the cellular receptor of epithelium, instigated endocytosis can likewise happen. This is conceivable through the association of the host epithelial cell epidermal development factor receptor with the invasins of candida cell. Post actuated endocytosis, discharged harmfulness factors by pathogens to improve capacity to enter to surface of mucosa. The oral and vaginal mucosa, which are terminally separated and non-proliferative, are made out of delineated layers more averse to work with intrusion of parasites by means of initiated endocytosis. Candida species should use an elective course to attack a tissue less inclined to help disguise in a cycle called dynamic infiltration. Dynamic infiltration interceded through hyphae augmentation (constrained by Ume6 and Eed1) is a contagious actuated cycle that needs reasonable parasitic hyphae [44]. Actual powers, attachment, and hydrolytic chemicals like SAP additionally assume a part. C. albicans uses dynamic entrance as the underlying way to attack the furthest layers of the epithelium in vivo. Be that as it may, prompted endocytosis could likewise be obvious of additional upgraded attack once the fundamental proliferative layers of the epithelium have been gotten to by the growth. Along these lines, both dynamic infiltration and initiated endocytosis are unthinkingly noticeable systems required for disease foundation through mucosal boundaries in vivo. When all is said in done, the pathogenesis of Candida begins with colonization, shallow disease, and profound situated contamination before spread contamination. The overall strides in tissue intrusion by C. albicans incorporate in the following stages.
Adhesion to the cellular epithelium.
Colonization.
Penetration to epithelium/hyphal invasion.
Dissemination of vasculature.
Endothelial colonization/penetration.
Systemic candida infection only occurs by immune system escape than vasculature penetration and invading the blood components. Entry to the bloodstream occurs via two routes:
Natural routes.
Artificial routes.
Above subsequent course is worked with biofilm arrangement as pathogens can get away and invade the blood. For Candida to endure and spread in the blood, various qualities are upregulated: qualities engaged with protein amalgamation, glycolytic cycle, glycolysis, and reaction to oxidative pressure. The presence of Candida in the blood prompts a condition called candidemia. From the blood, the yeast is dispersed to different fundamental organs in the body where it causes foundational contaminations. Dispersed candidiasis is profoundly worked with by extracellular hydrolytic compounds, adhesins, phenotypic exchanging, and cytolytic proteins. Candida in the blood can likewise bring about candiduria by antegrade contamination. Albeit most diseases include biofilm arrangement, a few contaminations can happen without the development of biofilm. Indeed, hyphae development and development are the beginning stages in the pathogenicity of Candida species, with the exception of C. glabrata that does not shape hyphae. It is notable that few qualities straightforwardly or by implication incited by natural irritations trigger hyphae arrangement.
Notwithstanding, questions actually remain with respect to the instruments controlling its union, the receptors, and its carrier. In outline, the exchanging of Candida spp. from commensal to artful microbe is ascribed to destructiveness factors that are specifically communicated under reasonable inclining conditions. The majority of these destructiveness factors are under close guideline. More examinations in their administrative instruments could be fundamental in the mission for new antifungal specialists. Figure 1 is the significant organization of Candida destructiveness and pathogenesis showing the associations between the different pathogenic determinants and harmful variables.
Figure 1.
Simplified diagram illustrating the network of Candida virulence and pathogenicity. (1) planktonic yeast cells attach to surfaces. Favorable conditions facilitate overgrowth; adherence (2): The cells attach to host cells via adhesins; hyphae formation/extension (3): Environmental constrains induce the HSPs, signaling and adaptation pathways which induce morphology-associated genes. The formation of the hyphae marks the beginning of Candida pathogenesis. Epithelial/endothelial adhesion/invasion (4 and 6): This is facilitated by hydrolytic enzymes and it is achieved via two ways: Induced endocytosis and active penetration. Some species such as C. glabrata do not form hyphae; rather, they form biofilms (5) prior to the establishment of infection. Destruction of epithelial and mucosal surfaces by the enzymes and cytolytic proteins gives rise to different types of candidiasis (8). Yeast cells can enter the blood (7) and then disseminate to the vital organs where they establish new biofilms. Infections associated with biofilms are of great clinical significance. Major Candida infections include vulvovaginal, oropharyngeal, and gastrointestinal candidiasis, candidemia, candiduria, and intra-abdominal candidiasis. Key: Dashed lines: Signals and inductions; single-headed thick dark red arrow: Major route of Candida pathogenesis; curved double-arrow connector: Interaction/association between factors; T-shaped thin red line: Inhibitory signal. The pool of virulence encoding genes house both the genes involved in hyphae and biofilm formation and other vital processes crucial for pathogenesis.
2.2 Host response to Candida species
Host insusceptible acknowledgment of Candida happens through a few instruments involving intrinsic and versatile insusceptibility. The versatile insusceptible framework perceives explicit antigenic moieties, prompting the advancement of a focused on safe reaction. Interestingly, inborn insusceptible acknowledgment is vague and wide and is the primary line of host protection against possibly hazardous organisms. These vague reactions are promptly endless supply of an organism in a pre-modified design and assume a fundamental part in controlling contagious weights and forestalling infection. Natural invulnerability includes a progression of dissolvable (supplement) and cell (neutrophil, macrophage) parts that act in show to keep by far most of microbes from setting up an intrusive disease. Further, it has become progressively clear that these reactions capacity to enact versatile insusceptibility just as acting along with other homeostatic cycles to give further security. Natural invulnerable acknowledgment of Candida happens through the acknowledgment of microorganism related atomic examples (PAMPs).
PAMPs are themes or particles that are regular between various sorts of growths. In contrast to antigens, individual PAMPs are not explicit to a solitary Candida animal variety but instead are divided among various species and contagious genera. These microbial PAMPs are perceived by have germline encoded design acknowledgment receptors (PRRs) [45] and give a pre-customized method of parasitic acknowledgment, taking into consideration moment acknowledgment of normal contagious parts. Most of contagious PAMPs are cell divider related and incorporate 𝛽-glucans, 𝑁-and 𝑂-connected mannans, and phospholipomannans [46]. These are perceived by three key PRR families: cost like receptors (TLRs), C-type lectin receptors (CLRs), and nucleotide-restricting area leucine-rich receptors (NLRs) [46, 47, 48, 49, 50, 51, 52]. Dendritic cells, monocytes, macrophages, polymorphonuclear leukocytes (PMNs), Tcells, Bcells, and epithelial cells all transmit PRRs on a surface level, in endosomes or in the cytoplasm of host cells. Sanctioning of these PRRs by PAMPs prompts setting off of intracellular hailing pathways, as MAPK (mitogen-started protein kinase) and NF-𝜅B (nuclear factor kappa-light-chain-enhancer of incited B cells) pathways, and finally to further developed record of countless characteristics drew in with have safe protections, including chemokines, cytokines, provocative center individuals, and antimicrobial peptides. Appropriately, PRRs are fundamental center individuals among intrinsic and adaptable safe responses.
3. Receptor molecules in Candida recognition
While comparing the human genome with murine genome; human genome encodes for ten TLR characteristics (TLR1–10) and murine genome encodes 12 i.e. TLR1 to TLR9 and TLR11 to TLR13. Each TLRs depicted as transmembrane type-1receptors having an enriched lucine extracellularly intermittent region which sees target PAMP and a Toll/interleukin-1 receptor-(TIR-) space containing cytoplasmic region that imparts the institution stimuli, which having closeness to the sort 1 interleukin-1 (IL-1) receptor. TLR family is a developmentally monitored gathering of PRRs that react to an assortment of bacterial, viral, and contagious PAMPs just as some endogenous components delivered when have cells are harmed. The extracellular areas of TLRs perceive an assortment of microbial PAMPs, including lipopolysaccharide (LPS), peptidoglycan, proteins (counting triacylated proteins and flagellin), and changed nucleic acids [53, 54, 55, 56, 57, 58].
3.1 Toll like receptors
3.1.1 TLR recognition of Candida
Key part for TLRs in host protection against fungal infection was initially identified when Drosophila inadequate in Toll receptor were seen to profoundly helpless to A. fumigatus disease [59]. Therefore by far most of the underlying antifungal insusceptibility research focused on how contagious cells were perceived. This provoked the distinctive verification of a couple of PRRs related with affirmation of different cell divider polysaccharides of parasites and C. albicans explicitly, including TLR2 (phospholipomannan), TLR4 (𝑂-associated mannan), and mannose receptor (MR) (𝑁-associated mannan) [46, 48, 60].
At last, these investigations finished in the disclosure of another PRR, dectin-1 (dendritic cell associated C-type lectin-1), who perceives parasitic 𝛽-1,3 glucan [61]. Outstandingly, these parasitic PRRs can work both freely and related to each other. For instance, dectin-1 and TLR2 act additionally to perceive contagious yeasts, with dectin-1 prompting phagocytosis while TLR2 initiates cytokine creation [62, 63, 64]. Dectin-1 likewise synergises with TLR4 flagging [64]. Moreover, TLR1 and TLR6 structure heterodimers with TLR2 [65] however do not seem to assume a significant part in C. albicans acknowledgment in a mouse model of intrusive candidiasis [66]. Obviously depending upon the coreceptor included, coligation of TLR2 may either update TLR2-subordinate responses [67] or change its PAMPs distinction concerning the circumstance with galectin-3 [68].
Even so these are standard receptors utilized by macrophages and neutrophils to see C. albicans, various receptors have moreover been perceived inclusive of dectin-2 [69], mincle (macrophage inducible CTL) [70], Dendritic cell specific intercellular grasp particle 3- getting nonintegrin (DC-SIGN ) [71, 72], and galectin-3 [68]. The piece of these PRRs is correct now not totally settled; regardless, dectin-2 and DC-SIGN are perceived to assume a significant part in the acknowledgment of high mannose structures [73] and galectin-3 in the acknowledgment of 𝛽-1,2 mannosides [68].
Curiously, galectin-3 coimmunoprecipitates accompanied by dectin-1 [74], which recommends that galectin-3 can work with associations among TLR2 and dectin-1 flagging. TLR acknowledgment of other medicinally significant growths have likewise been concentrated yet are less very much described, despite the fact that apparently TLR3 perceives A. fumigatus conidia and TLR4 perceives Cryptococcus neoformans glucuronoxylomannan, with TLR9 perceiving A. fumigatus, C. albicans and C. neoformans [75].
3.1.2 TLR signaling
PAMP acknowledgment of TLRs brings about enactment of flagging cascade intracellularly (Figure 2) through connection of the cytoplasmic TIR spaces with various connector proteins: myeloid separation essential reaction quality (88) (MyD88), MyD88-connector like (MAL), TIR-area containing connector initiating interferon-𝛽 (TRIF), and TRIF-related connector atom (TRAM) [53, 54, 55, 56, 57, 58, 76, 77, 78, 79]. This TLR-adapter interaction ends up in the activation of the IRAK ( IL-I receptor associated kinase) proteins and TRAF6 (TNF receptor associated factor-6). As a result it ends up in activation of the main signaling pathways together with NF-𝜅B, MAPK, and IRF (interferon regulative factor) pathways. MAPK activation contains 3 alleyways: p38, JNK (c-Jun N-terminal kinase), and ERKI/2 (extracellular signal-regulated kinaseI/2). Finally, signaling pathway induction ends up in the activation and nuclear localisation of transcription factors as well as NF-𝜅B, AP-I (activating macromolecule I), and IRF-3 and IRF-7. the result of this activation cascade is to induce organic phenomenon and secretion of varied proteins concerned in immune defense as well as cytokines, chemokines, antimicrobial peptides, and alternative inflammatory mediators, all of that operate to stimulate innate and reconciling responses of immune system. It thought to be noted that the overwhelming majority of studies shaping the TLR-mediated pathways are performed victimization myeloid or humor cells, however elaborated analysis of TLR- mediated pathways in alternative cell varieties, and specifically animal tissue cells, could nonetheless establish novel and strange mechanisms of infectious agent (fungal) recognition and management at membrane surfaces.
Figure 2.
Signal pathway activation by TLRs and CLRs. TLRs and CLRs activate MAPK and NF-𝜅B signal pathways to varying extents, thereby allowing different innate immune responses to be generated. TLRs utilize TIR-domain containing adapter proteins such as MyD88, mal, TRAM, and TRIF. CLRs signal using ITAM domains within their cytoplasmic region (e.g., dectin-1) or associate with an ITAM-containing transducing protein (e.g., dectin-2 with FcR𝛾). Dectin-1 utilizes Src kinases and Syk kinase to activate a complex containing CARD9, MALT1, and Bcl1o to activate the downstream signal pathways. Figure adapted from [47].
3.1.3 Role of TLRs during Candida infection
Although animals missing the TLR signaling adaptor protein MyD88 are vulnerable to fungal infection [46, 80, 81, 82], the exact role of particular TLR receptors in fighting Candida infections is unclear. This is most likely because of contrasts in examination plan, where diverse contagious species, morphotypes, and courses of contamination have been surveyed [52]. Thusly, contemplates utilizing TLR knockout mice have uncovered critical contrasts in the putative jobs of various TLRs in fundamental or mucosal insusceptible reactions against contagious contaminations [83]. For instance, while a few examinations demonstrate that TLR2 and TLR4 impact vulnerability to murine scattered candidiasis [82, 84, 85, 86], not all investigations support this attestation [87, 88]. TLR7 might be needed for parasitic RNA acknowledgment in the autophagosome, which is needed for IFN-𝛽 discharge and is related with delayed C. glabrata contamination [89]. TLR9 perceives C. albicans DNA (unmethylated CpG arrangements) bringing about cytokine creation in dendritic cells [90]; notwithstanding, TLR9 knockout mice do not seem, by all accounts, to be more helpless to C. albicans contamination, notwithstanding delivering diminished degrees of IL-I2 and expanded measures of IL-4 and IL-I0 [82, 90, 91, 92]. Outstandingly, explicit TLRs (TLR2, TLR4, TLR6, and TLR9) seem to hold various jobs relying upon which arm of the inborn invulnerable reaction they draw in with, for instance, advancement of versatile reactions by working with antigen show in dendritic cells [93].
A few examinations have related normal hereditary variations (polymorphisms) in TLR qualities with vulnerability or inclination to foundational candidiasis or constant mucocutaneous candidiasis (CMC). These recollect polymorphisms for TLRI (R80T , N248S , and S602I) [94, 95] and TLR3 (L4I2F) [96, 97]. Polymorphisms in TLR4 (D299G) and TLR2 (D753Q) have moreover been perceived as possible frailty markers for basic candidiasis [98] yet these could not be approved in a greater report [95]. As of now, a large portion of the information accessible recommends a solid part for TLRs in antifungal protection however recognizing explicit jobs for each TLR has been over shadowed by repetitive signs instigated by other PRRs [94].
3.2 C-type lectin receptors
CLRs (C-type lectin receptors) are a diverse restriction protein family defined by the presence of an extracellular carb acknowledgment space (CRD) or a C-type lectin like area (CTLD) [99]. The job of CLRs in antifungal insusceptibility has been the subject of serious investigation as of late and a few key CLRs have now been shown to show basic capacities in Candida acknowledgment, take-up, and executing and furthermore add to the commencement and additionally tweak of the resistant reaction to organisms [46, 100, 101]. By and by, the key CTLs in Candida affirmation appear, apparently, to be dectin-I, dectin-2, and MR. CLRs signal through incitation of ITAM/ITIM (immunoreceptor tyrosine-based actuation/restraint theme) cytoplasmic areas (Figure 3). This can be done by using their own cytoplasmic area, as dectin-I does, or by using coreceptor cytoplasmic spaces, as DAPI2 (DNAX actuation protein of I2 kDa) and FcR (Fc receptor gamma chain) do, as dectin-2 does. The activation of numerous connections to those activated by TLRs, most notably Src family kinases including Src, Lyn, and Fyn, is triggered when CLRs are ligated. If we talk about dectin-I , it prompts initiation of spleen tyrosine kinase (SYK) and the downstream actuation of the CARD9/BclI0/MALTI (caspase enlistment space family/B cell CLL-lymphoma I0/mucosa related lymphoid tissue lymphoma movement quality I) flagging complex. Independent of the CLR pathways and connectors utilized, a definitive outcome is the enactment of comparative flagging pathways as those initiated by TLRs, overwhelmingly NF-𝜅B and MAPK, that are discussed below point.
Figure 3.
Signaling and damage pathways activated by C. albicanshyphae. C. albicanshyphal cells, when in sufficient quantities, are recognized by an unknown PRR mechanism that results in the activation of NF-𝜅B, MAPK, and PI3K pathways. MAPK signaling via p38 and ERK1/2 appears to discriminate between yeast and hyphal cells. Activation of p38 by hyphae leads to activation of the c-Fos transcription factor, which, in conjunction with the p65/p50 NF-𝜅B heterodimers and PI3K/AKT results in upregulation of cytokine and inflammatory mediator expression. Concurrently, activation of ERK1/2 signaling, results in stabilization of the MKP1 phosphatase, which deactivates p38 and JNK, hence acting as part of a negative feedback loop and preventing a potentially deleterious overreaction of theimmune system. Damage induced by hyphae appears to be mediated via JNK activation and prevented via the PI3K/AKT/mTor pathway.
3.2.1 Dectin-I
Dectin-I, (also called CLEC7a) is that the main CLR known as taking part in a serious role in fungous recognition by the host system [102] and may be a sort II transmembrane macromolecule that belongs to a subgroup of CLRs referred to as natural killer (NK) receptor-like CLRs. The target ligands of dectin-I are 𝛽-I,3 glucan polymers, that comprise a serious part (∼60%) of fungous cell walls. The intracellular region of dectin-I contains a changed ITAM motif containing one amino acid residue rather than the standard 2 (hence the terms hem-ITAM or hemi- ITAM). Activation of the dectin-I results in phosphorylation of this domain and phosphorylation of SYK and activation of the BclI0- CARD9-MALTI complicated as mentioned on top of. This results in activation of each the canonical and noncanonical NF-𝜅B pathways [103] further as nuclear issue of activated T cells (NFAT) pathway [104]. Dectin-I can even induce signaling via Raf-I in an exceedingly SYK -dependent fashion [103] and is related to phospholipase C and A2 activation [50]. one in all the most important functions of dectin-I binding seems to be the induction of bodily process [105]. However, a singular feature of dectin-I is its ability to be activated or suppressed by its target matter. to completely activate dectin-I, cells got to be exposed to insoluble 𝛽-glucan particles. Notably, exposure of dectin-I to soluble 𝛽-glucan seems to dam activation. This appears to ensue to the apparent form type a vegetative cell conjunction,“whereby phosphatases that usually suppress ITAM motifs are accumulated. This exclusion later permits the phosphorylation of the intracellular hem-ITAM motif [106], thereby sanctioning bodily process. Dectin-I has additionally been shown to synergise with each TLR2 and TLR4, leading to the induction of tumor necrosis factor (TNF), IL-I0, transforming growth factor (TGF) and dendritic cell maturation [107, 108, 109]. In view of the fact that the 𝛽 - I,3 glucan polymers that are the main components of the fungal cell wall, and a strong activation of the immune system, dectin-I plays an important role in inducing antifungal activity of the host. This may also explain why some of the mold surface structure of “the mask” -I.3 glucan from the immune system. For example, Histoplasma capsulatum, masks are 𝛽-I,3 glucan, with a low - 𝛼-I,3 glucan [110] and it seems likely that the C. albicans hyphae of 𝛽-I,3 glucan has been covered over by layers of 𝑁 - 𝑂 - linked mannoproteins in order to prevent the discovery of the dectin-I. However, the yeast is in the form of C. albicans, while 𝑁 - 𝑂 - linked mannoproteins present in the underlying 𝛽 -glucan layer is exposed in the developing gut, which dectin-I in order to be recognized. Thus, it could be concluded that the most important role of dectin-I in the control of the yeast form of candidiasis (thrush). In addition, 𝛽 - glucan, which has been in the hyphal cell wall of C. albicans, it seems to be structurally different from the yeast 𝛽 - glucan [111] and, therefore, may not be immune to or understood by the dectin-I.
Although some studies have shown that the expression of dectin-I in the epithelial cells of the gastro- intestinal tract [112], and lung [113, 114], in oral epithelial cells express dectin-1 [115, 116]. What’s interesting is that dectin-I expression appears to be reduced in the presence of live C. albicans cells [116], and it is not affected by the dectin-I ligands [115, 117]. This suggests that dectin-I is likely to play only a minor role in the detection of C. albicans epithelial cells. Studies carried out with the help of dectin-I knockout mice have provided mixed data sets for the C. albicans systemic infection models, to demonstrate these differences, [118] and increased mortality [119] depending on the study, the C. albicans strain used. On the one hand, it is the work for the dectin-I is supported by the consideration that CARD9 knockout mice are susceptible to the most important infection [120] and in patients with head-and-CARD9 immunity and are particularly vulnerable to both the lining and the main foundation candidiasis [121]. In addition, another study, it has been the study of the normal function of the genetic polymorphism in CARD9 (SI2N), to CADR9, especially candidiasis, it is recommended that the method of fixing of the 𝛽 - glucan may be excessive for the first invulnerability of C. albicans [122]. However, recent studies have shown the potential role of dectin-I in the maintenance of tissue health. Dectin-I−/− the mice showed greater severity of the disease, at least one more commonly, however, this weight can be reduced by the removal of fungal and bacterial flora in [123]. Histologically, extensive infestations of fungi have been recorded from the underlying tissue, which was not seen in wild-type mice. Clinical trial data have shown that a subgroup of patients with ulcerative colitis, especially in aggressive disease, and shows a common single-nucleotide polymorphisms (rs2078I78 in dectin-I, possibly indicating a requirement for functional dectin-I receptors, and to maintain, mucosal health, in a commensal state [123]. However, the role of dectin-I in the intramucosal infections, it is far from clear, as recent studies in mice have demonstrated that dectin-I does not play an important role in the control of gastro-intestinal colonization by C. albicans [124]. In particular, it is well known that, in humans, mutations in the stop codon (Tyr238X in dectin-I is associated with an increased risk of developing mucocutaneous fungal infections, with an increased colonization of the oral cavity and the gastrointestinal (gi) tract and vulvovaginal candidiasis (thrush) infection (RVVC) [125, 126]. In another case, we obtained that the dectin-I polymorphism (I223S) was associated with oropharyngeal candidiasis (OPC) the susceptibility of West Africa, a group of HIV-positive patients [127]. That is why, even though the great one, the precise role of dectin-I in the susceptibility to candida infection is still unclear and requires further investigation.
3.2.2 Dectin-2
Dectin-2 (otherwise called CLEC6a) is a sort II transmembrane protein however is enacted contrastingly to dectin-I. Dectin-2 comes up short on an intracellular flagging area [128] and requirements to dimerise with FcR𝛾, which has an intracellular flagging space, to send a sign [69]. In myeloid cells and fiery monocytes, dectin-2 perceives high mannose structures that are normal to numerous parasites and ties to hyphae with higher proclivity than to yeast [129, 130]. This may clarify why dectin-2 inadequate mice are helpless to C. albicans contamination be that as it may, strangely, not C. neoformans [130, 131]. Dectin-2 may moreover recognize 𝛼-mannosyl linkages [132]. Dectin-2 may activate a number of cytokines and chemokines via NF-B, MAPK, SYK, CARD9-BclI0-MaltI, and PKC, as well as initiate the NLRP3 (NOD-like receptor family, pyrin region containing 3) inflammasome and a respiratory burst [69, 133]. Furthermore, dectin-2 may have a role in protecting against C. glabrata illnesses, since dectin-2/lacking mice were more susceptible to C. glabrata infections, indicating a poor transmittable choice in kidneys [134].
3.2.3 Dectin-3
Dectin-3 (additionally called CLECsf8, MCL, or CLEC4d) was as of late distinguished and seems to shape heterodimers with dectin-2 to perceive 𝛼-mannans on the outside of C. albicans hyphae, prompting NF-𝜅B enactment [135]. Strikingly, dectin-3−/− mice were exceptionally helpless to C. albicans disease. Contrasted and their particular homodimers, dectin-2/3 heterodimers bound 𝛼-mannans all the more viably, prompting strong incendiary reactions. This recommends that distinctive CLRs may shape an assortment of hetero and homodimers that may give diverse affectability and variety to have cells to identify different contagious contaminations.
3.2.4 DC-SIGN
DC-SIGN (otherwise called CD209) is another sort II transmembrane receptor that is communicated dominatingly on dendritic cells and macrophages. Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin) also known as CD209 (Cluster of Differentiation 209) is a protein which in humans is encoded by the CD209 gene. DC-SIGN is a C-type lectin receptor present on the surface of both macrophages and dendritic cells Nonetheless, the part of DC-SIGN in antifungal invulnerability is muddled [101], in spite of the fact that DC-SIGN seems to perceive high (𝑁-connected) mannose containing glycoproteins and actuate IL-6 creation [71, 136]. Albeit the part of DC-SIGN in the endocytosis and take-up of microbes to advance antigen show is all around recorded [136, 137], its job in phagocytosis is sketchy [71, 136].
3.3 Mannose receptor
The MR (or called CD206) is a prototypical kind I transmembrane protein that is transcendently communicated on macrophage and dendritic cells. MR receptor ties a few starch particles, including extended 𝑁-connected mannans, N-acetylglucosamine, glucose, and fucose [138]. Thus, MR can perceive numerous contagious, bacterial, and viral pathogens. MR needs regular intracellular flagging spaces despite the fact that ligation actually prompts an assortment of cell reactions, including signal pathway acceptance, phagocytosis, advancement of antigen show to T cells, and cytokine discharge [63, 136, 137, 138, 139, 140]. For instance, the MR is enlisted to the phagosome after C. albicans ingestion and actuates intracellular flagging and cytokine creation [141]. MR may likewise be needed for the enlistment of defensive ThI7 reactions in C. albicans contamination [140] however may repress cytokine creation because of different organisms, for instance, Pneumocystis carinii [142]. Remarkably, MR inadequacy does not seem to present helplessness to C. albicans foundational disease [143] as it does to C. neoformans [144], albeit minor changes in parasitic weights can be noticed [143]. In oral epithelial cells, MR impeding does not modify the discharge of IL-6, IL-8, and GM-CSF upon incitement with Candida cell divider parts [117]. As of now, there is no conclusive part for MR in mucosal antifungal host safeguards.
3.4 Nod-like receptors (NLRs) and inflammasomes
NLRs are a group of intracellular PRRs portrayed by leucine rich rehashes and a nucleotide-restricting area that identify PAMPs present in the cell cytoplasm. Like TLRs and CTLs, NLRs perceive microbial items yet they additionally perceive have determined threat signals or alarmins [145]. There are now 23 human NLRs and 34 mouse NLRs identified [146]. Inflammasomes are huge multimeric protein structures framed by NLRs and two distinct proteins, ASC (apoptosis-related spot like protein containing a CARD) and procaspase-I (procysteine-subordinate aspartate-coordinated protease I). The inflammasome’s main function is to convert procaspase-I to dynamic caspase-I, which causes young cells that are friendly to IL-I and supportive of IL- I8 to produce IL-I and IL-I8 [147]. Despite the fact that C. albicans is not recognized by NLRCI (NLR family CARD space containing protein I) or NLRC2 [148], it is known to activate inflammasomes fusing NLRP3 (NACHT , LRR, and PYD spaces containing protein 3) [149] and NLRC4 [150], resulting in the production of IL-I.
Surprisingly, NLRP3 is strongly expressed in nonkeratinizing epithelia, such as the oral cavity and throat [151], suggesting a possible role for NLRP3 in parasitic recognition in oral epithelial cells, which is supported by studies showing increased IL- I and IL- I8 levels in response to C. albicans stimulation [115, 152, 153, 154, 155]. Mice missing NLRP3 appear to be susceptible to candidiasis [156], but mice lacking IL-I receptor type I (IL- IRI), IL-I8, or caspase-I exhibit distinct contagious contamination helplessness profiles [157]. Strikingly, IL-I𝛽 (and IL-I𝛼) lacking mice show expanded mortality during scattered candidiasis [158]. Late reports have likewise recognized a significant part for NLRP3 along with TLR2 and dectin-I in forestalling dispersal of C. albicans in a murine model of oral contamination [159]. Steady with a part for NLRP3 inmucosal security [160], deficient NLRP3 actuation expands C. albicans colonization in the gut and fuels Crohn’s illness [161], and a length polymorphism in intron 4 of the quality (CIASI) that codes for NLRP3 inclines patients to RVVC [162]. Nevertheless, the full degree of the practical jobs for NLRs and inflammasomes in antifungal host safeguards is as yet not completely comprehended.
4. Protein involves in pathogenesis
4.1 Mincle
Mincle (also known as CLEC4e or CLECsf9) is a type II transmembrane protein that transmits its signal after dimerizing with the FcR connector protein [128]. Macrophages, monocytes, neutrophils, myeloid dendritic cells, and certain B cell subsets all communicate mincle, while plasmacytoid dendritic cells, T cells, and NK cells do not [133]. Mincle binds -mannans-containing starch structures [143, 163] and detects C. albicans [70, 164, 165], Malassezia spp. [163], and Fonsecaea pedrosoi, the chromoblastomycosis causative pathogen [166]. As with dectin-2, mincle is not believed to be needed for phagocytosis [70] yet adds to the acceptance of cytokines and chemokines by means of NF-𝜅B, MAPK, SYK, CARD9-BclI0-MatIt, and PKC𝛿 [133, 163]. In spite of the fact that mincle-incited reactions have all the earmarks of being MyD88 autonomous, mincle may synergise with TLRs to instigate fiery cytokines and the respiratory burst [167].
4.2 Soluble proteins in Candida recognition
The supplement course assumes a significant part in have protection against parasitic microorganisms and is quickly enacted in light of host attack by Candida [168, 169, 170]. Candida actuates each of the three known pathways (old style, elective, and mannose-restricting lectin (MBL)) with nobody clear pathway overwhelming the reaction [171]. Given that the Candida cell surface is covered with a bounty of manno proteins, it is not astonishing that Candida microorganisms are viable at actuating the MBL pathway, which seems significant for opsonisation, phagocytosis, and other supplement capacities [172, 173]. The connection between enacted C3b and the supplement receptor CR3 is generally needed for the uptake of Candida cells by phagocytes [174]. C. albicans cell divider proteins (e.g., GpmI, PraI, and Gpd2) can possibly tie supplement segments, for example, Factor H, FHL-I, C4BP and plasminogen from human plasma that meddle with phagocytic opsonisation and take-up [168, 170, 175, 176, 177, 178, 179, 180]. For example, restricting of Pra1 to factor H and FHL-1 most likely includes an avoidance methodology including the hindrance of C3 cleavage into opsonic and anaphylatoxic parts, in this manner forestalling acknowledgment and take-up by phagocytes [181]. C5 is likewise significant in Candida diseases since mice that need practical C5 quality duplicates are vulnerable to obtrusive foundational contaminations [182, 183, 184, 185]. C5 insufficiency is related with expanded creation of proinflammatory cytokines (TNF𝛼 and IL-6) and fast parasitic replication in organs that can prompt cardiovascular disappointment [186, 187]. Sanctioning of C5 prompts the improvement of C5b, which consequently triggers the plan of the film attack complex (MAC). Despite the fact that affidavit of MAC on the outside of C. albicans does not bring about fungicidal movement, presumably because of the thickness of the parasitic cell divider, it might work with the incitement of phagocytes and ensuing arrival of terminal supplement segments from these phones. Curiously, as no impact on irritation is recognized in C3 insufficient mice, this may recommend a generally C3-free preparing of C5 in foundational C. albicans disease [188]. After phagocytosis, the oxidative burst is set off which prompts contagious executing, a cycle that can be hindered with monoclonal antibodies to forestall C3b-CR3 associations. C3b-CR3 contact also appears to be crucial for lymphocyte hyphal formation and cytokine production [189]. MBL has also been linked to the inhibition of Candida development [190] and the enhancement of TNF release from Candida-infected monocytes [191]. C3a, an anaphylatoxin released by C3 during supplement enactment, may have direct antifungal activity independent of its chemotactic effect [192]. These findings suggest that complement activation is critical in the host’s defense against C. albicans infections. The reader is directed to the following reviews [168, 170] for further in-depth information on the involvement of complement in Candida infections.
5. Cellular responses to Candida
5.1 Neutrophils
Neutrophils are a key effector cell in intrinsic insusceptibility, and they play a dual role in antifungal responses. First, they phagocytose and destroy contaminated Candida cells (below), and then, via cross communication with epithelial cells, they indirectly assist in mucosal protection (tended to above). TLRs and CTLs help neutrophils phagocytose nonopsonized Candida, while CR3 and the Fc receptor (FcR) help them phagocytose opsonized Candida [193]. Once phagocytosed, Candida is killed both inside and outside the cell through oxidative and nitrosative mechanisms, but fungicidal movement varies across Candida species [194, 195]. Preformed cytoplasmic granules interweave with the phagosome intracellularly, although unlike macrophages, no substantial pH changes occur [196]. Antimicrobial proteins found in neutrophil granules include defensins, lactoferrin, lysozyme, myeloperoxidase, and elastase [197], all of which can be transported into the extracellular environment. Candida’s phagocytic execution requires oxidative processes. During the oxidative burst, neutrophils create reactive oxygen species (ROS), which needs the NADPH oxidase catalyst complex to assemble in the cytoplasmic and phagosomal film [198]. First, the superoxide extremist is formed, which is subsequently dismutated to hydrogen peroxide, an oxidative and harmful particle [199].
Then, myeloperoxidase uses hydrogen peroxide to create hypochlorous acid, which is moreover an exceptionally oxidative particle that responds with natural amines to frame chloramines that have further antimicrobial stuffs [193, 200]. Candida’s phagocytic execution is further aided by reactive nitrogen species (RNS) [193]. When neutrophils are activated, they produce nitric oxide (NO) from arginine and oxygen via an enzyme called inducible nitric oxide synthase (iNOS). NO is extremely sensitive, and it is converted to peroxynitrite, which is then reduced to nitrogen dioxide and a hydroxyl radical. Because iNOS is restricted to the intracellular compartment, RNS production is restricted to the intracellular compartment [199]. The creation of neutrophil extracellular catches (NETs) [201, 202], which are formed during a unique sequence of neutrophil cell death known as NETosis, is another more recently found way of Candida executing. Similar to serine proteases, antimicrobial peptides (e.g., calprotectin), and other microbicidal chemicals, the neutrophil “explodes,” unleashing a snare of chromatin fibrils coated with the neutrophil’s material. Candida spp. are well-versed in surviving the oxidative, nitrosative, osmotic, and restorative nerves encountered during interactions with neutrophils. Because of the weights, many cycles, features, and proteins are altered within the organism. These include upregulation of transporters (e.g., oligopeptide, ammonium, and iron), use of alternative carbon and nitrogen sources and metabolic cycles (e.g., glycolysis, glyoxylate, unsaturated fat, and amino destructive), and detoxification of neutrophil oxidative/nitrosative butchering instruments. (e.g., catalase, superoxide dismutases, and nitric oxide dioxygenase). In any event, these nuances are beyond the scope of this examination, and the reader is directed to a later examination that focuses on the Candida reaction to neutrophils [193, 203].
5.2 Macrophages
Macrophages can function as phagocytic cells as well as antigen-presenting cells capable of activating T lymphocytes. Upon activation, macrophages divide into two phenotypically and functionally distinct subsets, M1 and M2, based on the cytokine milieu in which they are initiated [204, 205, 206]. The M1 total is derived from receptiveness to the T colleague (Th)1 cytokine IFN, whereas the M2 total is derived from receptiveness to Th2 cytokines, IL-4 and IL- 13. M1 macrophages are microbic and proinflammatory, whereas M2 macrophages are involved in wound healing and extracellular network upgradation. Macrophages, like neutrophils, see and phagocytoze nonopsonised Candida via TLRs and CTLs, and opsonised Candida via CR3 and FcR [193, 207]. Nonetheless, macrophage phagosome formation differs from neutrophil phagosome development in that macrophage phagosomes follow the endocytic development route and grow into phagolysosomes with a distinctive acidic pH that promotes compound activity, such as cathepsin D [208]. M1 macrophages use both oxidative and nitrosative executing components (as seen above for neutrophils), but they also use the RNS, NO, to directly kill phagocytosed Candida via the translocation of iNOS. TNF and the chemokines CXCL9 and CXCL10 are also released by M1 macrophages [209]. These chemokines act as ligands for the CXCR3 receptor, which is found on Th1 cells and NK cells, attracting resistant cells to contamination sites.
M2 macrophages, then again, advance contagious ingenuity inside the macrophage, giving an instrument to invulnerable avoidance. M2 macrophages additionally express more significant levels of MR (CD206) bringing about expanded phagocytosis of Candida [210]. Correspondingly, the arginase-1 (Arg1) quality is additionally expanded in articulation, which rivals iNOS for a similar substrate (arginine), consequently diminishing NO levels [211]. This is additionally exacerbated by decreased degrees of TNF𝛼 creation in M2 macrophages. In light of this, macrophages anticipate playing an important role in Candida protection, but this is contingent on the Candida strain assisting the macrophage [212]. Candida spp., like neutrophils, are believed to rely on relative adaptations to survive in macrophages. C. albicans and C. glabrata have been shown to alter metabolic requirements by using alternative carbon sources, upregulating impetuses for gluconeogenesis, glyoxylate cycle, and -oxidation of unsaturated lipids, and downregulating protein synthesis and glycolysis [193, 207]. This combines the formation of catalase and superoxide dismutases for extracellular ROS detoxification [213] and the outflow of flavohemoglobin impetuses for intracellular RNS butchering [214]. Concerning C. albicans, intracellular dealing additionally seems unusual and the growth may repress both lysosomal fermentation and NO delivery [215]. For additional subtleties the peruser is guided to ongoing surveys that emphasis on the Candida reaction to macrophages [207].
Besides these receptors molecules, actively participated proteins and cellular mechanism system there is a lot of others factors in these mechanisms are linked like adhesins and invasins, biofilm formation, contact sensing and thigmotropism, secreted hydrolases, pH-sensing and its regulation, environment and metabolic adaptation, small HSPs, metal acquisition. So, for a complete understanding these factors also play significant role in pathogenicity mechanism of C. albicans.
6. Conclusion
This chapter has discussed the pathogenicity mechanism along with host and cellular responses in Candida species. Host reactions to Candida are profoundly assorted because of the assortment of contagious PAMPs and antigens perceived by various safe cells at different disease destinations. Many inquiries have been conducted on this important topic, particularly with C. albicans, and thus we have obtained a much improved understanding of the appropriate structures of the PAMPs & PRRs. Still, further analysis is needed in order to attain insight into the complex communication between PAMPs and the corresponding receptors. Definitely, co-stimulation via multiple PAMP–PRR interactions may increase together the sensitivity as well as the specificity of the immune recognition process.
\n',keywords:"Pathogenicity, C. albicans, TLR, receptor, lectin",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/78427.pdf",chapterXML:"https://mts.intechopen.com/source/xml/78427.xml",downloadPdfUrl:"/chapter/pdf-download/78427",previewPdfUrl:"/chapter/pdf-preview/78427",totalDownloads:235,totalViews:0,totalCrossrefCites:0,dateSubmitted:"November 17th 2020",dateReviewed:"July 30th 2021",datePrePublished:"September 5th 2021",datePublished:"November 17th 2021",dateFinished:"September 5th 2021",readingETA:"0",abstract:"In normal human microbiome, the polymorphic fungus Candida albicans is a crucial member. C. albicans resides mostly in individual as harmless commensal life. In specific situations, however, C. albicans can cause diseases that cause contaminations of the skin to life-threatening fundamental contaminations. Pathogenesis of Candida species is contributed by multiple factors. Some of the major contributors are enlisted here. These include host pathogen interaction, receptors molecule like TLR recognition, TLR signaling, C type lectin receptors, Dectin 1,2 and 3, mannose receptor, mincle, DC sign, Nod-Like Receptors (NLRs) and inflammasomes, soluble molecules in candida recognition, cellular responses to candida such as neutrophils, macrophages. This chapter enlightens all the components of candida pathogenicity by the assessment of Candida species pathogenic determinants. All together these will explain the current knowledge about how these determinant factors and receptors modulate virulence as well as consequent infection. Better understanding of candida pathogenicity mechanism can be the resultant of better treatment guidelines along with development of novel antifungal agents. Overall, in this review we present an update in the current understanding of the insight of pathogenicity mechanisms in this important human pathogen.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/78427",risUrl:"/chapter/ris/78427",signatures:"Snigdha Pattnaik, Laxmidhar Maharana and Manoj Sethi",book:{id:"9614",type:"book",title:"Advances in Candida albicans",subtitle:null,fullTitle:"Advances in Candida albicans",slug:"advances-in-candida-albicans",publishedDate:"November 17th 2021",bookSignature:"Xinhui Wang",coverURL:"https://cdn.intechopen.com/books/images_new/9614.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:"978-1-83969-182-9",printIsbn:"978-1-83969-181-2",pdfIsbn:"978-1-83969-183-6",isAvailableForWebshopOrdering:!0,editors:[{id:"296531",title:"Dr.",name:"Xinhui",middleName:null,surname:"Wang",slug:"xinhui-wang",fullName:"Xinhui Wang"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"340179",title:"Prof.",name:"Snigdha",middleName:null,surname:"Pattnaik",fullName:"Snigdha Pattnaik",slug:"snigdha-pattnaik",email:"snigdhapattnaik@soa.ac.in",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"344962",title:"Prof.",name:"Laxmidhar",middleName:null,surname:"Maharana",fullName:"Laxmidhar Maharana",slug:"laxmidhar-maharana",email:"laxmidharmaharana@soa.ac.in",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"344963",title:"Mr.",name:"Manoj Kumar",middleName:null,surname:"Sethi",fullName:"Manoj Kumar Sethi",slug:"manoj-kumar-sethi",email:"manojkmr976@gmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Pathogenicity mechanism of Candida species",level:"1"},{id:"sec_2_2",title:"2.1 Infection",level:"2"},{id:"sec_3_2",title:"2.2 Host response to Candida species",level:"2"},{id:"sec_5",title:"3. Receptor molecules in Candida recognition",level:"1"},{id:"sec_5_2",title:"3.1 Toll like receptors",level:"2"},{id:"sec_5_3",title:"3.1.1 TLR recognition of Candida",level:"3"},{id:"sec_6_3",title:"3.1.2 TLR signaling",level:"3"},{id:"sec_7_3",title:"3.1.3 Role of TLRs during Candida infection",level:"3"},{id:"sec_9_2",title:"3.2 C-type lectin receptors",level:"2"},{id:"sec_9_3",title:"3.2.1 Dectin-I",level:"3"},{id:"sec_10_3",title:"3.2.2 Dectin-2",level:"3"},{id:"sec_11_3",title:"3.2.3 Dectin-3",level:"3"},{id:"sec_12_3",title:"3.2.4 DC-SIGN",level:"3"},{id:"sec_14_2",title:"3.3 Mannose receptor",level:"2"},{id:"sec_15_2",title:"3.4 Nod-like receptors (NLRs) and inflammasomes",level:"2"},{id:"sec_17",title:"4. Protein involves in pathogenesis",level:"1"},{id:"sec_17_2",title:"4.1 Mincle",level:"2"},{id:"sec_18_2",title:"4.2 Soluble proteins in Candida recognition",level:"2"},{id:"sec_20",title:"5. Cellular responses to Candida",level:"1"},{id:"sec_20_2",title:"5.1 Neutrophils",level:"2"},{id:"sec_21_2",title:"5.2 Macrophages",level:"2"},{id:"sec_23",title:"6. Conclusion",level:"1"}],chapterReferences:[{id:"B1",body:'Vincent JL, Rello J, Marshall J, Silva E, Anzueto A, Martin CD et al (2009) EPIC II Group of Investigators. International study of the prevalence and outcomes of infection in intensive care units. JAMA 302:2323-2329'},{id:"B2",body:'Ingham CJ, Boonstra S, Levels S, de Lange M, Meis JF, Schneeberger PM (2012) Rapid susceptibility testing and microcolony analysis of Candida spp. cultured and imaged on porous aluminium oxide. PLoS ONE 7:e33818'},{id:"B3",body:'Correia A, Sampaio P, Vilanova M, Pais C (2015) Candida albicans: clinical relevance, pathogenesis, and host immunity. In: Sing SK (ed) Human emerging and re-emerging infections: viral and parasitic infections, vol 1. John Wiley and Sons, New Jersey, pp 926-952'},{id:"B4",body:'Limon JJ, Skalski JH, Underhill DM (2017) Commensal fungi in health and disease. Cell Host Microbes 22:156-165'},{id:"B5",body:'De Rosa FG, Garazzino S, Pasero DC, Peri GD (2009) Invasive candidiasis and candidemia: new guidelines. Minerva Anaestesiologica 75:453-458'},{id:"B6",body:'Negri M, Faria M, Guilhermetti E, Alves A, Paula C, Svidzinski T (2010) Hemolytic activity and production of germ tubes related to pathogenic potential of clinical isolates of Candida albicans. J Basic Appl Pharm. 31:89-93'},{id:"B7",body:'Silva S, Negri M, Henriques M, Oliveira R, Williams DW, Azeredo J (2011) Adherence and biofilm formation of non- Candida albicans Candida species. Trends Microbio 19:241-247'},{id:"B8",body:'Wisplinghoff H, Seifert H, Tallent SM, Bischoff T, Wenzel RP, Edmond MB (2003a) Nosocomial bloodstream infections in pediatric patients in United States hospitals: epidemiology, clinical features and susceptibilities. Pediatr Infect Dis J 22:686-691'},{id:"B9",body:'Bongomin F, Gago S, Oladele R, Denning D (2017) Global and multi-national prevalence of fungal diseases-estimate precision. J Fungi 3:57'},{id:"B10",body:'Dadar M, Tiwari R, Karthik K, Chakraborty S, Shahali Y, Dhama K (2018) Candida albicans-biology, molecular characterization, pathogenicity, and advances in diagnosis and control-an update. Microb Pathog 117:128-138'},{id:"B11",body:'Caceres DH, Forsberg K, Welsh RM, Sexton DJ, Lockhart SR, Jackson BR et al (2019) Candida auris: a review of recommendations for detection and control in health care settings. J Fungi 5:111'},{id:"B12",body:'Aslam B,Wang W, Arshad MI, Khurshid M,Muzammil S, Rasool MH et al (2018) Antibiotic resistance: a rundown of a global crisis. Infect Drug Resist 11:1645-1658'},{id:"B13",body:'Kornitzer D (2019) Regulation of Candida albicans hyphal morphogenesis by endogenous signals. J Fungi 5:21'},{id:"B14",body:'Wisplinghoff H, Elobers J, Geurtz L, Stefanik D, Major Y, Edmond MB et al (2014) Nosocomial bloodstream infections due to Candida spp. in the USA: species distribution, clinical features and antifungal susceptibilities. Int J Antimicrob Agents 43:78-81'},{id:"B15",body:'Perez JC, Johnson AD (2013) Regulatory circuits that enable proliferation of the fungus Candida albicans in a mammalian host. PLoS Pathogen 9(12):e1003780'},{id:"B16",body:'Jacobsen ID, Hube B (2017) Candida albicans morphology: still in focus. Expert Rev Anti Infect Ther 15:327-330'},{id:"B17",body:'AokiW, Kitahara N,Miura N, Morisaka H, Yamamoto Y, Kuroda K et al (2011) Comprehensive characterization of secreted aspartic proteases encoded by a virulence gene family in Candida albicans. J BioChem 150:431-438'},{id:"B18",body:'Seman BG, Moore JL, Scherer AK, Blair BA, Manandhar S, Jones JM et al (2018) Yeast and filaments have specialized, independent activities in a zebrafish model of Candida albicans infection. Infect Immun 86:e00415–e00418'},{id:"B19",body:'Desai JV, Cheng S, Ying T, NguyenMH, Clancy CJ, Lanni F et al (2015) Coordination of Candida albicans invasion and infection functions by phosphoglycerol phosphatase Rhr2. Pathogens 4: 573-589'},{id:"B20",body:'Kadosh D (2017) Morphogenesis in C. albicans. In: Prasad R (ed) Candida albicans: Cell Mol Biol. Springer, Cham'},{id:"B21",body:'Han TL, Cannon RD, Villas-Boas SG (2011) The metabolic basis of Candida albicans morphogenesis and quorum sensing. Fungal Genet Biol 48:747-763'},{id:"B22",body:'Monge RA, Román E, Nombela C, Pla J (2006) The MAP kinase signal transduction network in Candida albicans. Microbiology 152:905-912'},{id:"B23",body:'Gong Y, Li T, Yu C, Sun S (2017) Candida albicans heat shock proteins and Hsps-associated signaling pathways as potential antifungal targets. Front Cell Infect Microbiol 7:520'},{id:"B24",body:'Smith DA, Nicholls S,Morgan BA, Brown AJP, Quinn JA (2004) Conserved stress-activated protein kinase regulates a core stress response in the human pathogen Candida albicans.Mol Biol Cell 15:4179-4190'},{id:"B25",body:'Hogan D, Sundrom P (2009) The Ras/Camp/PKA signaling pathways and virulence in Candida albicans. Future Microbiol 4: 1263-1270'},{id:"B26",body:'Lin C-J, Wu C-Y, Yu S-J, Chen Y-L (2018) Protein kinase A governs growth and virulence in Candida tropicalis. Virulence 9(1):331-347'},{id:"B27",body:'Inglis DO, Sherlock G (2013) Ras signaling gets fine-tuned: regulation of multiple pathogenic traits of Candida albicans. Eukaryot Cell 12:1316-1325'},{id:"B28",body:'Lin CJ, Chen YL (2018) Conserved and divergent functions of the cAMP/PKA signaling pathway in Candida albicans and Candida tropicalis. J Fungi 4:68'},{id:"B29",body:'DavisDA (2009) Howhuman pathogenic fungi sense and adapt to pH: the link to virulence. Curr Opin Microbiol 12:365-370'},{id:"B30",body:'Brown A, Haynes K, Gow N, Quinn J (2012) Stress responses in Candida, 2nd edn. ASM Press, Washington, D.C., pp 225-242'},{id:"B31",body:'Zhou Y, LiaoM, Zhu C, Hu Y, Tong T, Peng X et al (2018) ERG3 and ERG11 genes are critical for the pathogenesis of Candida albicans during the oral mucosal infection. Int J Oral Sci 10:9'},{id:"B32",body:'de Oliveira SGC, Vasconcelos CC, Lopes AJO, de Sousa Cartagenes MDS, Filho AKDB, do Nascimento FRF et al (2018) Candida infections and therapeutic strategies: mechanisms of action for traditional and alternative agents. Front Microbiol 9:1351'},{id:"B33",body:'Dantas SA, Lee KK, Raziunaite I, Schaefer K, Wagener J, Yadav B et al (2016) Cell biology of Candida albicans-host interactions. Curr Opin Microbiol 34:111-118'},{id:"B34",body:'Schonherr FA, Sparber F, Kirchner FR, Guiducci E, Trautweinweidner K, Gladiator A et al (2017) The interspecies diversity of C. albicans triggers qualitatively and temporally distinct host responses that determine the balance between commensalism and pathogenicity. Mucosal Immunol 10:1335-1350'},{id:"B35",body:'Braunsdorf C, LeibundGut-Landmann S (2018) Modulation of the fungal-host interaction by the intra-species diversity of C. albicans. Pathogens 7:11'},{id:"B36",body:'Reedy JL, Filler SG, Heitman J (2010) Elucidating the Candida albicans calcineurin signaling cascade controlling stress response and virulence. Fungal Genet Biol 47:107'},{id:"B37",body:'Liu S, Liu W (2015) Components of the canclium-calcinerium signaling pathways in fungal cells and their potential as antifungal targets. Eukaryot Cell 14:4'},{id:"B38",body:'Yu Q, Jia C, Dong Y, Zhang B, Xiao C, Chen Y et al (2015) Candida albicans autophagy, no longer a bystander: its role in tolerance to ER stress-related antifungal drugs. Fungal Genet Biol 81:238-249'},{id:"B39",body:'Shang-Jie Y, Ya-Lin C, Ying-Lie C (2015) Calcineurin signaling: lessons from Candida species. FEMS Microbiol 15:4'},{id:"B40",body:'Wang L, Lin X (2012) Morphogenesis in fungal pathogenesis: shape, size and surface. PLoS Pathog 8:e1003027'},{id:"B41",body:'Kim S, Nguyen QB,WolyniakMJ, Frechette G, Lehman CR, Fox BK et al (2018) Release of transcriptional repression through the HCR promoter region confers uniform expression of HWP1 on surfaces of Candida albicans germ tubes. PLoS ONE 13: e0192260'},{id:"B42",body:'Sharma J, Rosiana S, Razzaq I, Shapiro RS (2019) Linking cellular morphogenesis with antifungal treatment and susceptibility in Candida pathogens. J Fungi 5:17'},{id:"B43",body:'Sun JN, Solis NV, Phan QT, Bajwa JS, Kashlera H, Thompson A et al (2010) Host cell invasion and virulence mediated by Candida albicans Ssai. PLos Pathog 6:e1001181'},{id:"B44",body:'Wächtler B,Wilson D, Haedicke K, Dalle F, Hube B (2011) From attachment to damage: defined genes of Candida albicans mediate adhesion, invasion and damage during interaction with oral epithelial cells. PLoS One 6:e17046'},{id:"B45",body:'C. A. Janeway Jr. and R. Medzhitov, “Innate immune recognition,” Annual Review of Immunology, vol. 20, pp. 197-216, 2002'},{id:"B46",body:'M. G. Netea, G. D. Brown, B. J. Kullberg, and N. A. R. Gow, “An integrated model of the recognition of Candida albicans by the innate immune system,“Nature ReviewsMicrobiology, vol. 6, no. 1, pp. 67-78, 2008'},{id:"B47",body:'J. R. Naglik and D. Moyes, “Epithelial cell innate response to Candida albicans.,” Advances in dental research, vol. 23, no. 1, pp. 50-55, 2011'},{id:"B48",body:'A. Roeder, C. J. Kirschning, R. A. Rupec, M. Schaller,G.Weindl, and H. C. Korting, “Toll-like receptors as key mediators in innate antifungal immunity,” Medical Mycology, vol. 42, no. 6, pp. 485-498, 2004'},{id:"B49",body:'G. Weindl, J. Wagener, and M. Schaller, “Epithelial cells and innate antifungal defense,” Journal of Dental Research, vol. 89, no. 7, pp. 666-675, 2010'},{id:"B50",body:'A. Plato, J. A. Willment, and G. D. Brown, “C-Type lectinlike receptors of the dectin-1 cluster: Ligands and signalling pathways,” International Reviews of Immunology, vol. 32, no. 2, pp. 134-156, 2013'},{id:"B51",body:'D. J. Philpott, M. T. Sorbara, S. J. Robertson, K. Croitoru, and S. E. Girardin, “NOD proteins: regulators of inflammation in health and disease,” Nature Reviews Immunology, vol. 14, pp. 9-23, 2014'},{id:"B52",body:'C. Bourgeois and K. Kuchler, “Fungal pathogens—a sweet and sour treat for toll-like receptors,” Frontiers in Cellular and Infection Microbiology, vol. 2, article 142, 2012'},{id:"B53",body:'S. Akira, “Mammalian Toll-like receptors,” Current Opinion in Immunology, vol. 15, no. 1, pp. 5-11, 2003'},{id:"B54",body:'K. Takeda, T. Kaisho, and S. Akira, “Toll-like receptors,” Annual Review of Immunology, vol. 21, pp. 335-376, 2003'},{id:"B55",body:'S. Akira and K. Takeda, “Toll-like receptor signalling,” Nature Reviews Immunology, vol. 4, no. 7, pp. 499-511, 2004'},{id:"B56",body:'K. Takeda and S. Akira, “TLR signaling pathways,” Seminars in Immunology, vol. 16, no. 1, pp. 3-9, 2004'},{id:"B57",body:'T. Kawai and S. Akira, “Pathogen recognition with Toll-like receptors,” Current Opinion in Immunology, vol. 17, no. 4, pp. 338-344, 2005'},{id:"B58",body:'T. Kawai and S. Akira, “TLR signaling,” Seminars in Immunology, vol. 19, no. 1, pp. 24-32, 2007'},{id:"B59",body:'B. Lemaitre, E. Nicolas, L. Michaut, J. Reichhart, and J. A. Hoffmann, “The dorsoventral regulatory gene cassette spatzle/Toll/Cactus controls the potent antifungal response in Drosophila adults,” Cell, vol. 86, no. 6, pp. 973-983, 1996'},{id:"B60",body:'T. Jouault, S. Ibata-Ombetta, O. Takeuchi et al., “Candida albicans phospholipomannan is sensed through toll-like receptors,” Journal of Infectious Diseases, vol. 188, no. 1, pp. 165-172, 2003'},{id:"B61",body:'G. D. Brown, P. R. Taylor, D.M. Reid et al., “Dectin-1 is a major 𝛽-glucan receptor on macrophages,” Journal of Experimental Medicine, vol. 196, no. 3, pp. 407-412, 2002'},{id:"B62",body:'K. M. Dennehy, J. A. Willment, D. L. Williams, and G. D. Brown, “Reciprocal regulation of IL-23 and IL-12 following coactivation of dectin-1 and TLR signaling pathways,” European Journal of Immunology, vol. 39, no. 5, pp. 1379-1386, 2009'},{id:"B63",body:'M. G. Netea, N. A. R. Gow, C. A. Munro et al., “Immune sensing of Candida albicans requires cooperative recognition of mannans and glucans by lectin and Toll-like receptors,” Journal of Clinical Investigation, vol. 116, no. 6, pp. 1642-1650, 2006'},{id:"B64",body:'G. Ferwerda, F. Meyer-Wentrup, B. Kullberg, M. G. Netea, and G. J. Adema, “Dectin-1 synergizes with TLR2 and TLR4 for cytokine production in human primary monocytes and macrophages,” Cellular Microbiology, vol. 10, no. 10, pp. 2058– 2066, 2008'},{id:"B65",body:'A.Ozinsky, D.M.Underhill, J.D. Fontenot et al., “The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors,” Proceedings of the National Academy of Sciences of the United States of America, vol. 97, no. 25, pp. 13766-13771, 2000'},{id:"B66",body:'M. G. Netea, F. Van De Veerdonk, I. Verschueren, J.W. M. Van DerMeer, andB. J. Kullberg, “RoleofTLR1 andTLR6 in thehost defense against disseminated candidiasis,” FEMS Immunology and Medical Microbiology, vol. 52, no. 1, pp. 118-123, 2008'},{id:"B67",body:'S. P. Smeekens, F. L. van de Veerdonk, J. W. M. van der Meer, B. J. Kullberg, L. A. B. Joosten, andM. G.Netea, “The Candida Th17 response is dependent on mannanand 𝛽-glucan-induced prostaglandin E2,” International Immunology, vol. 22, no. 11, pp. 889-895, 2010'},{id:"B68",body:'T. Jouault, M. El Abed-El Behi, M. Mart’ınez-Esparza et al., “Specific recognition of Candida albicans by macrophages requires galectin-3 to discriminate Saccharomyces cerevisiae and needs association with TLR2 for signaling,” Journal of Immunology, vol. 177, no. 7, pp. 4679-4687, 2006'},{id:"B69",body:'K. Sato, X. Yang, T. Yudate et al., “Dectin-2 is a pattern recognition receptor for fungi that couples with the Fc receptor 𝛾 chain to induce innate immune responses,” The Journal of Biological Chemistry, vol. 281, no. 50, pp. 38854-38866, 2006'},{id:"B70",body:'C. A. Wells, J. A. Salvage-Jones, X. Li et al., “The macrophageinducible C-type lectin, mincle, is an essential component of the innate immune response to Candida albicans,” Journal of Immunology, vol. 180, no. 11, pp. 7404-7413, 2008'},{id:"B71",body:'A. Cambi, K. Gijzen, I. J. M. de Vries et al., “The C-type lectin DC-SIGN (CD209) is an antigen-uptake receptor for Candida albicans on dendritic cells,” European Journal of Immunology, vol. 33, no. 2, pp. 532-538, 2003'},{id:"B72",body:'P.R.Taylor,G.D. Brown, J.Herre,D. L.Williams, J. A.Willment, and S.Gordon, “TheRole of SIGNR1 and the 𝛽-GlucanReceptor (Dectin-1) in the Nonopsonic Recognition of Yeast by Specific Macrophages,” Journal of Immunology, vol. 172, no. 2, pp. 1157-1162, 2004'},{id:"B73",body:'M. G. Netea and B. J. Kullberg, “Epithelial sensing of fungal invasion,” Cell Host andMicrobe, vol. 8, no. 3, pp. 219-220, 2010'},{id:"B74",body:'A. Esteban, M.W. Popp, V. K. Vyas, K. Strijbis,H. L. Ploegh, and G. R. Fink, “Fungal recognition is mediated by the association of dectin-1 and galectin-3 in macrophages,” Proceedings of the National Academy of Sciences of the United States of America, vol. 108, no. 34, pp. 14270-14275, 2011'},{id:"B75",body:'L. Romani, “Immunity to fungal infections,” Nature Reviews Immunology, vol. 11, no. 4, pp. 275-288, 2011'},{id:"B76",body:'L. B. Ivashkiv, “A signal-switch hypothesis for cross-regulation of cytokine and TLR signalling pathways,” Nature Reviews Immunology, vol. 8, no. 10, pp. 816-822, 2008'},{id:"B77",body:'S. V. Tsoni and G. D. Brown, “𝛽-Glucans and dectin-1,” Annals of the New York Academy of Sciences, vol. 1143, pp. 45-60, 2008'},{id:"B78",body:'E. F. Kenny and L. A. J. O’Neill, “Signalling adaptors used by Toll-like receptors: an update,” Cytokine, vol. 43, no. 3, pp. 342-349, 2008'},{id:"B79",body:'L. A. J. O’Neill, “The interleukin-1 receptor/Toll-like receptor superfamily: 10 Years of progress,” Immunological Reviews, vol. 226, no. 1, pp. 10-18, 2008'},{id:"B80",body:'E. Villam’on, D. Gozalbo, P. Roig et al., “Myeloid differentiation factor 88 (MyD88) is required formurine resistance to Candida albicans and is critically involved in Candida-induced production of cytokines,” European Cytokine Network, vol. 15, no. 3, pp. 263-271, 2004'},{id:"B81",body:'C. Bourgeois,O.Majer, I. E. Frohner, L. Tierney, and K. Kuchler, “Fungal attacks on mammalian hosts: pathogen elimination requires sensing and tasting,” Current Opinion in Microbiology, vol. 13, no. 4, pp. 401-408, 2010'},{id:"B82",body:'S. Bellocchio, C. Montagnoli, S. Bozza et al., “The contribution of the Toll-like/IL-1 receptor superfamily to innate and adaptive immunity to fungal pathogens in vivo,” The Journal of Immunology, vol. 172, no. 5, pp. 3059-3069, 2004'},{id:"B83",body:'M. L. Gil andD. Gozalbo, “Role of toll-like receptors insystemic Candida albicans infections,” Frontiers in Bioscience, vol. 14, no. 2, pp. 570-582, 2009'},{id:"B84",body:'M. G. Netea, C. A. A. van der Graaf, A. G. Vonk, I.Verschueren, J. W. M. Van der Meet, and B. J. Kullberg, “The role of tolllike receptor (TLR) 2 and TLR4 in the host defense against disseminated candidiasis,” Journal of Infectious Diseases, vol. 185, no. 10, pp. 1483-1489, 2002'},{id:"B85",body:'M.G.Netea, R. Sutmuller, C.Hermann et al., “Toll-like receptor 2 suppresses immunity against Candida albicans through induction of IL-10 and regulatory T cells,” Journal of Immunology, vol.172, no. 6, pp. 3712-3718, 2004'},{id:"B86",body:'M. G. Netea, N. A. R. Gow, L. A. B. Joosten, I. Verschueren, J. W. M. Van Der Meer, and B. J. Kullberg, “Variable recognition of Candida albicans strains by TLR4 and lectin recognition receptors,” Medical Mycology, vol. 48, no. 7, pp. 897-903, 2010'},{id:"B87",body:'E. Villam’on, D. Gozalbo, P. Roig et al., “Toll-like receptor 2 is dispensable for acquired host immune resistance to Candida albicans in a murine model of disseminated candidiasis,” Microbes and Infection, vol. 6, no. 6, pp. 542-548, 2004'},{id:"B88",body:'C. Murciano, E. Villamon, D. Gozalbo, P. Roig, J. E. O’Connor, and M. L. Gil, “Toll-like receptor 4 defective mice carrying point or null mutations do not show increased susceptibility to Candida albicans in a model of hematogenously disseminated infection,” Medical Mycology, vol. 44, no. 2, pp. 149-157, 2006'},{id:"B89",body:'C. Bourgeois, O. Majer, I. E. Frohner et al., “Conventional dendritic cells mount a type I IFN response against Candida spp. requiring novel phagosomal TLR7-mediated IFN-𝛽 signaling,” Journal of Immunology, vol. 186, no. 5, pp. 3104-3112, 2011'},{id:"B90",body:'A. Miyazato, K. Nakamura, N. Yamamoto et al., “Toll-like receptor 9-dependent activation of myeloid dendritic cells by deoxynucleic acids from Candida albicans,” Infection and Immunity, vol. 77, no. 7, pp. 3056-3064, 2009'},{id:"B91",body:'F. L. van de Veerdonk, M. G. Netea, T. J. Jansen et al., “Redundant role of TLR9 for anti-Candida host defense,” Immunobiology, vol. 213, no. 8, pp. 613-620, 2008'},{id:"B92",body:'C. Biondo, G. Signorino, A. Costa et al., “Recognition of yeast nucleic acids triggers a host-protective type I interferon response,” European Journal of Immunology, vol. 41, no. 7, pp. 1969-1979, 2011'},{id:"B93",body:'J. Magarian Blander and R. Medzhitov, “Toll-dependent selection of microbial antigens for presentation by dendritic cells,” Nature, vol. 440, no. 7085, pp. 808-812, 2006'},{id:"B94",body:'T. S. Plantinga, M.D. Johnson,W. K. Scott et al., “Human genetic susceptibility to Candida infections,” MedicalMycology, vol. 50, no. 8, pp. 785-794, 2012'},{id:"B95",body:'T. S. Plantinga,M.D. Johnson,W.K. Scott et al., “Toll-like receptor 1 polymorphisms increase susceptibility to candidemia,” Journal of Infectious Diseases, vol. 205, no. 6, pp. 934-943, 2012'},{id:"B96",body:'A. Nahum, H. Dadi, A. Bates, and C. M. Roifman, “The L412F variant of Toll-like receptor 3 (TLR3) is associated with cutaneous candidiasis, increased susceptibility to cytomegalovirus, and autoimmunity,” Journal of Allergy and Clinical Immunology, vol. 127, no. 2, pp. 528-531, 2011'},{id:"B97",body:'A. Nahum, H. Dadi, A. Bates, and C. M. Roifman, “The biological significance of TLR3 variant, L412F, in conferring susceptibility to cutaneous candidiasis, CMV and autoimmunity,” Autoimmunity Reviews, vol. 11, no. 5, pp. 341-347, 2012'},{id:"B98",body:'C. A. A. Van der Graaf, M. G. Netea, S. A. Morr’e et al., “Tolllike receptor 4 Asp299Gly/Thr399Ile polymorphisms are a risk factor for Candida bloodstream infection,” European Cytokine Network, vol. 17, no. 1, pp. 29-34, 2006'},{id:"B99",body:'A. N. Zelensky and J. E. Gready, “The C-type lectin-like domain superfamily,” FEBS Journal, vol. 272, no. 24, pp. 6179-6217, 2005'},{id:"B100",body:'S. E. Hardison and G. D. Brown, “C-type lectin receptors orchestrate antifungal immunity,” Nature Immunology, vol. 13, no. 9, pp. 817-822, 2012'},{id:"B101",body:'J. A. Willment and G. D. Brown, “C-type lectin receptors in antifungal immunity,” Trends in Microbiology, vol. 16, no. 1, pp. 27-32, 2008'},{id:"B102",body:'G. D. Brown, “Dectin-1 : a signalling non-TLR patternrecognition receptor,” Nature Reviews Immunology, vol. 6, no. 1, pp. 33-43, 2006'},{id:"B103",body:'S. I.Gringhuis, J. denDunnen,M. Litjens et al., “Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-𝜅B activation through Raf-1 and Syk,” Nature Immunology, vol. 10, no. 2, pp. 203-213, 2009'},{id:"B104",body:'D. M. Reid, N. A. Gow, and G. D. Brown, “Pattern recognition: recent insights fromDectin-1,” Current Opinion in Immunology, vol. 21, no. 1, pp. 30-37, 2009'},{id:"B105",body:'J. Herre, J. A. Willment, S. Gordon, and G. D. Brown, “The role of dectin-1 in antifungal immunity,” Critical Reviews in Immunology, vol. 24, no. 3, pp. 193-203, 2004'},{id:"B106",body:'H. S. Goodridge, C. N. Reyes, C. A. Becker et al., “Activation of the innate immune receptor Dectin-1 upon formation of a ‘Phagocytic synapse’,” Nature, vol. 472, no. 7344, pp. 471-475, 2011'},{id:"B107",body:'G. D. Brown, J. Herre, D. L. Williams, J. A. Willment, A. S. J. Marshall, and S. Gordon, “Dectin-1 mediates the biological effects of 𝛽-glucans,” Journal of ExperimentalMedicine, vol. 197, no. 9, pp. 1119-1124, 2003'},{id:"B108",body:'S. Dillon, S. Agrawal, K. Banerjee et al., “Yeast zymosan, a stimulus for TLR2 and dectin-1, induces regulatory antigenpresenting cells and immunological tolerance,” Journal of Clinical Investigation, vol. 116, no. 4, pp. 916-928, 2006'},{id:"B109",body:'B. N. Gantner, R. M. Simmons, S. J. Canavera, S. Akira, and D. M. Underhill, “Collaborative induction of inflammatory responses by dectin-1 and toll-like receptor 2,” Journal of Experimental Medicine, vol. 197, no. 9, pp. 1107-1117, 2003'},{id:"B110",body:'C. A. Rappleye, L. G. Eissenberg, and W. E. Goldman, “Histoplasma capsulatum𝛼-(1,3)-glucan blocks innateimmune recognition by the 𝛽-glucan receptor,” Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 4, pp. 1366-1370, 2007'},{id:"B111",body:'D. W. Lowman, R. R. Greene, D. W. Bearden et al., “Novel structural features in Candida albicans hyphal glucan provide a basis for differential innate immune recognition of hyphae versus yeast,” The Journal of Biological Chemistry, vol. 289, pp. 3432-3443, 2014'},{id:"B112",body:'P. J. Rice, E. L. Adams, T. Ozment-Skelton et al., “Oral delivery and gastrointestinal absorption of soluble glucans stimulate increased resistance to infectious challenge,” Journal of Pharmacology and ExperimentalTherapeutics, vol. 314, no. 3, pp. 1079-1086, 2005'},{id:"B113",body:'S. E. Evans, P. Y. Hahn, F. McCann, T. J. Kottom, Z. V. Pavlovi’c, and A. H. Limper, “Pneumocystis cell wall 𝛽-glucans stimulate alveolar epithelial cell chemokine generation through nuclear factor-𝜅𝛽-dependent mechanisms,” The American Journal of Respiratory Cell and Molecular Biology, vol. 32, no. 6, pp. 490-497, 2005'},{id:"B114",body:'H. Lee, J. Yuk, D. Shin, and E. Jo, “Dectin-1 is inducible and plays an essential role for mycobacteria-induced innate immune responses in airway epithelial cells,” Journal of Clinical Immunology, vol. 29, no. 6, pp. 795-805, 2009'},{id:"B115",body:'D. L.Moyes, M. Runglall, C.Murciano et al., “A biphasic innate immune MAPK response discriminates between the yeast and hyphal forms of Candida albicans in epithelial cells,” Cell Host and Microbe, vol. 8, no. 3, pp. 225-235, 2010'},{id:"B116",body:'D. L. Moyes, C. Shen, C. Murciano et al., “Protection against epithelial damage during Candida albicans infection is mediated by PI3K/Akt and mammalian target of rapamycin signaling,” Journal of InfectiousDiseases, vol. 209, no. 11,pp. 1816-1826, 2014'},{id:"B117",body:'J. Wagener, G. Weindl, P. W. J. de Groot et al., “Glycosylation of Candida albicans cell wall proteins is critical for induction of innateimmune responses and apoptosis of epithelial cells,” PLoS ONE, vol. 7, no. 11,Article ID e50518, 2012'},{id:"B118",body:'S. Saijo, N. Fujikado, T. Furuta et al., “Dectin-1 is required for host defense against Pneumocystis carinii but not against Candida albicans,” Nature Immunology, vol. 8, no. 1, pp. 39-46, 2007'},{id:"B119",body:'P. R. Taylor, S. V. Tsoni, J. A. Willment et al., “Dectin-1 is required for 𝛽-glucan recognition and control of fungal infection,” Nature Immunology, vol. 8, no. 1, pp. 31-38, 2007'},{id:"B120",body:'O.Gross, A.Gewies, K. Finger et al., “Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity,” Nature, vol. 442, no. 7103, pp. 651-656, 2006'},{id:"B121",body:'A. Puel, S. Cypowyj, J. Bustamante et al., “Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity,” Science, vol. 332, no. 6025, pp. 65-68, 2011'},{id:"B122",body:'D. C. Rosentul, T. S. Plantinga, M. Oosting et al., “Genetic variation in the dectin-1/CARD9 recognition pathway and susceptibility to candidemia,” Journal of Infectious Diseases, vol. 204, no. 7, pp. 1138-1145, 2011'},{id:"B123",body:'I. D. Iliev, V. A. Funari, K. D. Taylor et al., “Interactions between commensal fungi and the C-type lectin receptor dectin-1 influence colitis,” Science, vol. 336, no. 6086, pp. 1314-1317, 2012'},{id:"B124",body:'S. Vautier, R. A. Drummond, P. Redelinghuys, G. I. Murray, D. M. MacCallum, and G. D. Brown, “Dectin-1 is not required for controlling Candida albicans colonization of the gastrointestinal tract,” Infection and Immunity, vol. 80,no. 12, pp. 4216-4222, 2012'},{id:"B125",body:'B. Ferwerda, G. Ferwerda, T. S. Plantinga et al., “Human dectin-1 deficiency and mucocutaneous fungal infections,” The New England Journal ofMedicine, vol. 361, no. 18, pp. 1760-1767, 2009'},{id:"B126",body:'T. S. Plantinga, W. J. F. M. Van Der Velden, B. Ferwerda et al., “Early stop polymorphism in human DECTIN-1 is associated with increased candida colonization in hematopoietic stem cell transplant recipients,” Clinical Infectious Diseases, vol. 49, no. 5, pp. 724-732, 2009'},{id:"B127",body:'T. S. Plantinga, O. J. M. Hamza, J. A. Willment et al., “Genetic variation of innate immune genes in HIV-infected African patients with or without oropharyngeal candidiasis,” Journal of Acquired ImmuneDeficiency Syndromes, vol. 55,no. 1, pp. 87-94, 2010'},{id:"B128",body:'L.M. Grahamand G. D. Brown, “TheDectin-2 family of C-type lectins in immunity and homeostasis,” Cytokine, vol. 48, no. 1-2, pp. 148-155, 2009'},{id:"B129",body:'E. P. McGreal, M. Rosas, G. D. Brown et al., “The carbohydrate recognition domain of Dectin-2 is a C-type lectin with specificity for high mannose,” Glycobiology, vol. 16, no. 5, pp. 422-430, 2006'},{id:"B130",body:'S. Saijo, S. Ikeda, K. Yamabe et al., “Dectin-2 recognition of 𝛼-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans,” Immunity, vol. 32, no. 5, pp. 681-691, 2010'},{id:"B131",body:'M. J. Robinson, F. Osorio, M. Rosas et al., “Dectin-2 is a Syk coupled pattern recognition receptor crucial forTh17 responses to fungal infection,” Journal of Experimental Medicine, vol. 206, no. 9, pp. 2037-2051, 2009'},{id:"B132",body:'N. Hirata, K. Ishibashi, W. Sato et al., “Beta-mannosyl linkages inhibit CAWS arteritis by negatively regulating dectin-2-dependent signaling in spleen and dendritic cells,” Immunopharmacology and Immunotoxicology, vol. 35, pp. 594-604, 2013'},{id:"B133",body:'B. Kerscher, J. A. Willment, and G. D. Brown, “The Dectin-2 family of C-type lectin-like receptors: an update,” International Immunology, vol. 25, no. 5, pp. 271-277, 2013'},{id:"B134",body:'D. C. Ifrim, J. M. Bain,D. M. Reid et al., “The role of Dectin-2 for host defense against systemic infection with Candida glabrata,” Infection and Immunity, vol. 82, no. 3, pp. 1064-1073, 2014'},{id:"B135",body:'L. Zhu, X. Zhao, C. Jiang et al., “C-type lectin receptors dectin-3 and dectin-2 form a heterodimeric pattern-recognition receptor for host defense against fungal infection,” Immunity, vol. 39, no. 2, pp. 324-334, 2013'},{id:"B136",body:'A. Cambi, M. G. Netea, H. M. Mora-Montes et al., “Dendritic cell interaction with Candida albicans critically depends on Nlinked Mannan,” The Journal of Biological Chemistry, vol. 283, no. 29, pp. 20590-20599, 2008'},{id:"B137",body:'J. S. Lam, H. Huang, and S. M. Levitz, “Effect of differential N-linked and O-linked mannosylation on recognition of fungal antigens by dendritic cells,” PLoS ONE, vol. 2, no. 10, Article ID e1009, 2007'},{id:"B138",body:'P. R. Taylor, S. Gordon, and L. Martinez-Pomares, “The mannose receptor: linking homeostasis and immunity through sugar recognition,” Trends in Immunology, vol. 26, no. 2, pp. 104-110, 2005'},{id:"B139",body:'U. Gazi,M. Rosas, S. Singh et al., “Fungal recognition enhances mannose receptor shedding through dectin-1 engagement,” Journal of Biological Chemistry, vol. 286, no. 10, pp. 7822-7829, 2011'},{id:"B140",body:'F. L. van de Veerdonk, R. J. Marijnissen, B. J. Kullberg et al., “The macrophage mannose receptor induces IL-17 in response to Candida albicans,” Cell Host and Microbe, vol. 5, no. 4, pp. 329-340, 2009'},{id:"B141",body:'S. E.M. Heinsbroek, P. R. Taylor, F. O.Martinez, L. Martinez- Pomares, G. D. Brown, and S. Gordon, “Stage-specific sampling by pattern recognition receptors during Candida albicans phagocytosis,” PLoS Pathogens, vol. 4, no. 11, Article ID e1000218, 2008'},{id:"B142",body:'J. Zhang, S. D. Tachado, N. Patel et al., “Negative regulatory role of mannose receptors on human alveolar macrophage proinflammatory cytokine release in vitro,” Journal of Leukocyte Biology, vol. 78, no. 3, pp. 665-674, 2005'},{id:"B143",body:'S. J. Lee,N. Zheng,M. Clavijo, andM.C.Nussenzweig, “Normal host defense during systemic candidiasis in mannose receptordeficient mice,” Infection and Immunity, vol. 71, no. 1, pp. 437-445, 2003'},{id:"B144",body:'J. M. Dan, R. M. Kelly, C. K. Lee, and S. M. Levitz, “Role of the mannose receptor in a murine model of Cryptococcus neoformans infection,” Infection and Immunity, vol. 76, no. 6, pp. 2362-2367, 2008'},{id:"B145",body:'F. Martinon, A. Mayor, and J. Tschopp, “The inflammasomes: guardians of the body,” Annual Review of Immunology, vol. 27, pp. 229-265, 2009'},{id:"B146",body:'H. Kumar, T. Kawai, and S. Akira, “Pathogen recognition by the innate immune system,” International Reviews of Immunology, vol. 30, no. 1, pp. 16-34, 2011'},{id:"B147",body:'C. Bryant and K. A. Fitzgerald, “Molecular mechanisms involved in inflammasome activation,” Trends in Cell Biology, vol. 19, no. 9, pp. 455-464, 2009'},{id:"B148",body:'C. A. A. Van Der Graaf, M. G. Netea, B. Franke, S. E. Girardin, J.W. M. VanDerMeer, and B. J. Kullberg, “Nucleotide oligomerization domain 2 (Nod2) is not involved in the pattern recognition ofCandida albicans,” Clinical andVaccine Immunology, vol. 13, no. 3, pp. 423-425, 2006'},{id:"B149",body:'S. Joly, N. Ma, J. J. Sadler, D. R. Soll, S. L. Cassel, and F. S. Sutterwala, “Cutting edge: Candida albicans hyphae formation triggers activation of the Nlrp3 inflammasome,” Journal of Immunology, vol. 183, no. 6, pp. 3578-3581, 2009'},{id:"B150",body:'J. Tomalka, S. Ganesan, E. Azodi et al., “A novel role for the NLRC4 inflammasome in mucosal defenses against the fungal pathogen Candida albicans,” PLoS Pathogens, vol. 7, no. 12, Article ID e1002379, 2011'},{id:"B151",body:'J. A. Kummer, R. Broekhuizen,H. Everett et al., “Inflammasome componentsNALP 1 and 3 showdistinct but separate expression profiles in human tissues suggesting a site-specific role in the inflammatory response,” Journal of Histochemistry and Cytochemistry, vol. 55, no. 5, pp. 443-452, 2007'},{id:"B152",body:'Y.Mostefaoui, I.Claveau, andM. Rouabhia, “In vitro analyses of tissue structure and interleukin-1𝛽 expression and production by human oral mucosa in response to Candida albicans infections,” Cytokine, vol. 25, no. 4, pp. 162-171, 2004'},{id:"B153",body:'M. Rouabhia, G. Ross, N. Pag’e, and J. Chakir, “Interleukin-18 and gamma interferon production by oral epithelial cells in response to exposure to Candida albicans or lipopolysaccharide stimulation,” Infection and Immunity, vol. 70, no. 12, pp. 7073-7080, 2002'},{id:"B154",body:'G.Weindl, J. R. Naglik, S. Kaesler et al., “Human epithelial cells establish direct antifungal defense through TLR4-mediated signaling,” The Journal of Clinical Investigation, vol. 117, no. 12, pp. 3664-3672, 2007'},{id:"B155",body:'F. Tardif, J. Goulet, A. Zakrazewski, P. Chauvin, and M. Rouabhia, “Involvement of interleukin-18 in the inflammatory response against oropharyngeal candidiasis,” Medical Science Monitor, vol. 10, no. 8, pp. BR239–BR249, 2004'},{id:"B156",body:'O. Gross, H. Poeck, M. Bscheider et al., “Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence,” Nature, vol. 459, no. 7245, pp. 433-436, 2009'},{id:"B157",body:'F. L. van de Veerdonk, B. J. Kullberg, J. W. van der Meer, N. A. Gow, and M. G. Netea, “Host-microbe interactions: innate pattern recognition of fungal pathogens,” Current Opinion in Microbiology, vol. 11, no. 4, pp. 305-312, 2008'},{id:"B158",body:'A. G. Vonk,M.G.Netea, J.H.VanKrieken, Y. Iwakura, J.W. M. VanDerMeer, and B. J.Kullberg, “Endogenous interleukin (IL)-1𝛼 and IL-1𝛽 are crucial for host defense against disseminated candidiasis,” The Journal of Infectious Diseases, vol. 193, no. 10, pp. 1419-1426, 2006'},{id:"B159",body:'A. G. Hise, J. Tomalka, S. Ganesan et al., “An essential role for the NLRP3 inflammasome in host defense against the human fungal pathogen Candida albicans,” Cell Host and Microbe, vol. 5, no. 5, pp. 487-497, 2009'},{id:"B160",body:'M. H. Zaki,K.L.Boyd, P. Vogel,M. B. Kastan,M.Lamkanfi, and T. Kanneganti, “The NLRP3 Inflammasome Protects against Loss of Epithelial Integrity and Mortality during Experimental Colitis,” Immunity, vol. 32, no. 3, pp. 379-391, 2010'},{id:"B161",body:'L. M. Rehaume, T. Jouault, andM. Chamaillard, “Lessons from the inflammasome: a molecular sentry linking Candida and Crohn’s disease,” Trends in Immunology, vol. 31, no. 5, pp. 171-175, 2010'},{id:"B162",body:'A. Lev-Sagie, D. Prus, I. M. Linhares, Y. Lavy, W. J. Ledger, and S. S. Witkin, “Polymorphism in a gene coding for the inflammasome component NALP3 and recurrent vulvovaginal candidiasis in women with vulvar vestibulitis syndrome,” The American Journal of Obstetrics and Gynecology, vol. 200, no. 3, pp. 303.e1-303.e6, 2009'},{id:"B163",body:'S. Yamasaki, M. Matsumoto, O. Takeuchi et al., “C-type lectin Mincle is an activating receptor for pathogenic fungus, Malassezia,” Proceedings of the National Academy of Sciences of the United States of America, vol. 106, no. 6, pp. 1897-1902, 2009'},{id:"B164",body:'A. Bugarcic, K. Hitchens, A. G. Beckhouse, C. A. Wells, R. B. Ashman, and H. Blanchard, “Human and mouse macrophageinducible C-type lectin (Mincle) bind Candida albicans,” Glycobiology, vol. 18, no. 9, pp. 679-685, 2008'},{id:"B165",body:'D. Vijayan, K. J. Radford, A. G. Beckhouse, R. B. Ashman, and C. A.Wells, “Mincle polarizes humanmonocyte and neutrophil responses to Candida albicans,” Immunology and Cell Biology, vol. 90, no. 9, pp. 889-895, 2012'},{id:"B166",body:'M. Da Gl’oria Sousa, D. M. Reid, E. Schweighoffer et al., “Restoration of pattern recognition receptor costimulation to treat chromoblastomycosis, a chronic fungal infection of the skin,” Cell Host and Microbe, vol. 9, no. 5, pp. 436-443, 2011'},{id:"B167",body:'W. Lee, J. Kang, J. Yan et al., “Neutrophils promote mycobacterial trehalose dimycolate-induced lung inflammation via the mincle pathway,” PLoS Pathogens, vol. 8, no. 4, Article ID e1002614, 2012'},{id:"B168",body:'P. F. Zipfel, “Complement and immune defense: From innate immunity to human diseases,” Immunology Letters, vol. 126, no. 1-2, pp. 1-7, 2009'},{id:"B169",body:'P. F. Zipfel and C. Skerka, “Complement, Candida, and cytokines: the role of C5a in host response to fungi,” European Journal of Immunology, vol. 42, no. 4, pp. 822-825, 2012'},{id:"B170",body:'S. Luo, C. Skerka, O. Kurzai, and P. F. Zipfel, “Complement and innate immune evasion strategies of the human pathogenic fungus Candida albicans,“Molecular Immunology, vol. 56, no. 3, pp. 161-169, 2013'},{id:"B171",body:'C. Speth, G. Rambach, R. W¨urzner, and C. Lass-Fl¨orl, “Complement and fungal pathogens: an update,” Mycoses, vol. 51, no. 6, pp. 477-496, 2008'},{id:"B172",body:'N. Brouwer, K. M. Dolman, M. van Houdt, M. Sta, D. Roos, and T. W. Kuijpers, “Mannose-binding lectin (MBL) facilitates opsonophagocytosis of yeasts but not of bacteria despite MBL binding,” Journal of Immunology, vol. 180, no. 6, pp. 4124-4132, 2008'},{id:"B173",body:'O. Neth, D. L. Jack, A. W. Dodds, H. Holzel, N. J. Klein, and M. W. Turner, “Mannose-binding lectin binds to a range of clinically relevant microorganisms and promotes complement deposition,” Infection and Immunity, vol. 68, no. 2, pp. 688-693, 2000'},{id:"B174",body:'C. B. Forsyth and H. L. Mathews, “Lymphocytes utilize CD11b/CD18 for adhesion to Candida albicans,” Cellular Immunology, vol. 170, no. 1, pp. 91-100, 1996'},{id:"B175",body:'T. Meri, A. Hartmann, D. Lenk et al., “The yeast Candida albicans binds complement regulators factor H and FHL-1,” Infection and Immunity, vol. 70, no. 9, pp. 5185-5192, 2002'},{id:"B176",body:'T. Meri, A.M. Blom, A. Hartmann, D. Lenk, S. Meri, and P. F. Zipfel, “The hyphal and yeast forms of Candida albicans bind the complement regulator C4b-binding protein,” Infection and Immunity, vol. 72, no. 11, pp. 6633-6641, 2004'},{id:"B177",body:'V. Agarwal, T. M. Asmat, S. Luo, I. Jensch, P. F. Zipfel, and S. Hammerschmidt, “Complement regulator factor H mediates a two-step uptake of Streptococcus pneumoniae by human cells,” The Journal of Biological Chemistry, vol. 285, no. 30, pp. 23486-23495, 2010'},{id:"B178",body:'S. Poltermann, A. Kunert, M. Von Der Heide, R. Eck, A. Hartmann, and P. F. Zipfel, “Gpm1p is a factor H-, FHL-1-, and plasminogen-binding surface protein of Candida albicans,” Journal of Biological Chemistry, vol. 282, no. 52, pp. 37537-37544, 2007'},{id:"B179",body:'S. Luo, S. Poltermann, A. Kunert, S. Rupp, and P. F. Zipfel, “Immune evasion of the human pathogenic yeast Candida albicans: Pra1 is a Factor H, FHL-1 and plasminogen binding surface protein,“Molecular Immunology, vol. 47,no. 2-3, pp. 541-550, 2009'},{id:"B180",body:'S.Luo,A.M.Blom, S. Ruppet al., “ThepH-regulatedantigen1of Candida albicans binds the human complement inhibitor C4bbinding protein and mediates fungal complement evasion,” Journal of Biological Chemistry, vol. 286, no. 10, pp. 8021-8029, 2011'},{id:"B181",body:'S. Luo, A. Hartmann, H. Dahse, C. Skerka, and P. F. Zipfel, “Secreted pH-regulated antigen 1 of Candida albicans blocks activation and conversion of complement C3,” Journal of Immunology, vol. 185, no. 4, pp. 2164-2173, 2010'},{id:"B182",body:'R. B. Ashman, J. M. Papadimitriou, A. Fulurija et al., “Role of complement C5 and T lymphocytes in pathogenesis of disseminated and mucosal candidiasis in susceptible DBA/2 mice,” Microbial Pathogenesis, vol. 34, no. 2, pp. 103-113, 2003'},{id:"B183",body:'R. B. Ashman, E. M. Bolitho, and J.M. Papadimitriou, “Patterns of resistance to Candida albicans in inbred mouse strains,” Immunology and Cell Biology, vol. 71, no. 3, pp. 221-225, 1993'},{id:"B184",body:'R. B. Ashman, “Genetic determination of susceptibility and resistance in the pathogenesis of Candida albicans infection,” FEMS Immunology and Medical Microbiology, vol. 19, no. 3, pp. 183-189, 1997'},{id:"B185",body:'I. Radovanovic, A. Mullick, and P. Gros, “Genetic control of susceptibility to infection with Candida albicans in mice,” PLoS ONE, vol. 6, no. 4,Article ID e18957, 2011'},{id:"B186",body:'A. Mullick, M. Elias, S. Picard et al., “Dysregulated inflammatory response to Candida albicans in a C5-deficient mouse strain,” Infection and Immunity, vol. 72, no. 10, pp. 5868-5876, 2004'},{id:"B187",body:'A. Mullick, Z. Leon, G. Min-Oo et al., “Cardiac failure in C5- deficient A/J mice after Candida albicans infection,” Infection and Immunity, vol. 74, no. 8, pp. 4439-4451, 2006'},{id:"B188",body:'S.V. Tsoni, A.M. Kerrigan,M. J.Marakalala et al., “Complement C3 plays an essential role in the control of opportunistic fungal infections,” Infection and Immunity, vol. 77, no. 9, pp. 3679-3685, 2009'},{id:"B189",body:'C. B. Forsyth and H. L. Mathews, “Lymphocyte adhesion to Candida albicans,” Infection and Immunity, vol. 70, no. 2, pp. 517-527, 2002'},{id:"B190",body:'W. K. Ip and Y. L. Lau, “Role of mannose-binding lectin in the innate defense against Candida albicans: enhancement of complement activation, but lack of opsonic function, in phagocytosis by human dendritic cells,” Journal of Infectious Diseases, vol. 190, no. 3, pp. 632-640, 2004'},{id:"B191",body:'M. C. Ghezzi, G. Raponi, S. Angeletti, and C.Mancini, “Serummediated enhancement of TNF-𝛼 release by human monocytes stimulated with the yeast form of Candida albicans,” Journal of Infectious Diseases, vol. 178, no. 6, pp. 1743-1749, 1998'},{id:"B192",body:'A. Sonesson, L. Ringstad, E. Andersson Nordahl, M.Malmsten, M. M¨orgelin, and A. Schmidtchen, “Antifungal activity of C3a and C3a-derived peptides against Candida,” Biochimica et Biophysica Acta—Biomembranes, vol. 1768, no. 2, pp. 346-353, 2007'},{id:"B193",body:'P. Miram’on, L. Kasper, and B. Hube, “Thriving within the host: candida spp. interactions with phagocytic cells,” Medical Microbiology and Immunology, vol. 202, no. 3, pp. 183-195, 2013'},{id:"B194",body:'E. Svobodov’a, P. Staib, J. Losse, F. Hennicke, D. Barz, and M. J’ozsi, “Differential interaction of the two related fungal species Candida albicans and Candida dubliniensis with human neutrophils,” Journal of Immunology, vol. 189, no. 5, pp. 2502-2511, 2012'},{id:"B195",body:'J. R. Linden, M. A. MacCani, S. S. Laforce-Nesbitt, and J. M Bliss, “High efficiency opsonin-independent phagocytosis of Candida parapsilosis by human neutrophils,” MedicalMycology, vol. 48, no. 2, pp. 355-364, 2010'},{id:"B196",body:'W. L. Lee, R. E. Harrison, and S. Grinstein, “Phagocytosis by neutrophils,” Microbes and Infection, vol. 5, no. 14, pp. 1299-1306, 2003'},{id:"B197",body:'B. Amulic, C. Cazalet, G. L. Hayes, K. D. Metzler, and A. Zychlinsky, “Neutrophil function: From mechanisms to disease,” Annual Review of Immunology, vol. 30, pp. 459-489, 2012'},{id:"B198",body:'B. H. Segal, M. J. Grimm, A. N. H. Khan, W. Han, and T. S. Blackwell, “Regulation of innateimmunity byNADPHoxidase,” FreeRadical Biology andMedicine, vol. 53,no. 1, pp. 72-80, 2012'},{id:"B199",body:'F. C. Fang, “Antimicrobial reactive oxygen and nitrogen species: concepts and controversies,” Nature Reviews Microbiology, vol. 2, no. 10, pp. 820-832, 2004'},{id:"B200",body:'C. C. Winterbourn, M. B. Hampton, J. H. Livesey, and A. J. Kettle, “Modeling the reactions of superoxide and myeloperoxidase in the neutrophil phagosome: implications for microbial killing,” Journal of Biological Chemistry, vol. 281, no. 52, pp. 39860-39869, 2006'},{id:"B201",body:'C. F. Urban, U. Reichard, V. Brinkmann, and A. Zychlinsky, “Neutrophil extracellular traps capture and kill Candida albicans and hyphal forms,” Cellular Microbiology, vol. 8, no. 4, pp. 668-676, 2006'},{id:"B202",body:'C. F. Urban, D. Ermert, M. Schmid et al., “Neutrophil extracellular traps contain calprotectin, a cytosolic protein complex involved in host defense against Candida albicans,” PLoS Pathogens, vol. 5, no. 10, Article IDe1000639, 2009'},{id:"B203",body:'K. Seider, A. Heyken, A. L¨uttich, P. Miram’on, and B. Hube, “Interaction of pathogenic yeasts with phagocytes: survival, persistence and escape,” Current Opinion in Microbiology, vol. 13, no. 4, pp. 392-400, 2010'},{id:"B204",body:'P. Perumal, S. Mekala, C. Nombela, W. L. Chaffin, and C. Gil, “Proteomic analysis of cytoplasmic and surface proteins from yeast cells, hyphae, and biofilms of Candida albicans,” Proteomics, vol. 9, no. 8, pp. 2230-2252, 2009'},{id:"B205",body:'F. O. Martinez, L. Helming, and S. Gordon, “Alternative activation of macrophages: an immunologic functional perspective,” Annual Review of Immunology, vol. 27, pp. 451-483, 2009'},{id:"B206",body:'S. Gordon and F. O. Martinez, “Alternative activation of macrophages: mechanism and functions,” Immunity, vol. 32,no. 5, pp. 593-604, 2010'},{id:"B207",body:'C. Jim’enez-L’opez and M. C. Lorenz, “Fungal immune evasion in a model host-pathogen interaction: Candida albicans versus macrophages,” PLoS Pathogens, vol. 9, Article IDe1003741, 2013'},{id:"B208",body:'O. V. Vieira, R. J. Botelho, and S. Grinstein, “Phagosome maturation: aging gracefully,” Biochemical Journal, vol. 366, no. 3, pp. 689-704, 2002'},{id:"B209",body:'D. M. Mosser and J. P. Edwards, “Exploring the full spectrum of macrophage activation,” Nature Reviews Immunology, vol. 8, no. 12, pp. 958-969, 2008'},{id:"B210",body:'M. Stein, S. Keshav, N. Harris, and S. Gordon, “Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation,” Journal of ExperimentalMedicine, vol. 176, no. 1, pp. 287-292, 1992'},{id:"B211",body:'M.Hesse,M.Modolell, A. C. La Flamme et al., “Differential regulation of nitric oxide synthase-2 and arginase-1 by type 1/type 2 cytokines in vivo: granulomatous pathology is shaped by the pattern of L-arginine metabolism,” Journal of Immunology, vol.167, no. 11, pp. 6533-6544, 2001'},{id:"B212",body:'A. Tavanti, D. Campa, A. Bertozzi et al., “Candida albicans isolates with different genomic backgrounds display a differential response to macrophage infection,” Microbes and Infection, vol. 8, no. 3, pp. 791-800, 2006'},{id:"B213",body:'I. E. Frohner, C. Bourgeois, K. Yatsyk,O.Majer, andK. Kuchler, “Candida albicans cell surface superoxide dismutases degrade host-derived reactive oxygen species to escape innate immune surveillance,“MolecularMicrobiology, vol. 71,no. 1, pp. 240-252, 2009'},{id:"B214",body:'B. D. Ullmann, H. Myers, W. Chiranand et al., “Inducible defense mechanism against nitric oxide in Candida albicans,” Eukaryotic Cell, vol. 3, no. 3, pp. 715-723, 2004'},{id:"B215",body:'E. Fern’andez-Arenas, V. Cabez’on, C. Bermejo et al., “Integrated proteomics and genomics strategies bring new insight into Candida albicans response upon macrophage interaction,” Molecular and Cellular Proteomics, vol. 6, no. 3, pp. 460-478, 2007'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Snigdha Pattnaik",address:"snigdhapattnaik@soa.ac.in",affiliation:'
'}],corrections:null},book:{id:"9614",type:"book",title:"Advances in Candida albicans",subtitle:null,fullTitle:"Advances in Candida albicans",slug:"advances-in-candida-albicans",publishedDate:"November 17th 2021",bookSignature:"Xinhui Wang",coverURL:"https://cdn.intechopen.com/books/images_new/9614.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:"978-1-83969-182-9",printIsbn:"978-1-83969-181-2",pdfIsbn:"978-1-83969-183-6",isAvailableForWebshopOrdering:!0,editors:[{id:"296531",title:"Dr.",name:"Xinhui",middleName:null,surname:"Wang",slug:"xinhui-wang",fullName:"Xinhui Wang"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}}},profile:{item:{id:"165100",title:"Dr.",name:"Frédéric",middleName:null,surname:"Berger",email:"frederic.berger@irstea.fr",fullName:"Frédéric Berger",slug:"frederic-berger",position:null,biography:null,institutionString:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",totalCites:0,totalChapterViews:"0",outsideEditionCount:0,totalAuthoredChapters:"4",totalEditedBooks:"0",personalWebsiteURL:null,twitterURL:null,linkedinURL:null,institution:null},booksEdited:[],chaptersAuthored:[{id:"45192",title:"Monitoring Climatic Change Impacts on Protection Forests in Aosta Valley (Italy) and in Drôme (France) Using Medium and High Resolution Remote Sensing and Mateloscopes Plots",slug:"monitoring-climatic-change-impacts-on-protection-forests-in-aosta-valley-italy-and-in-dr-me-france-u",abstract:null,signatures:"Laurent Borgniet, David Toe, Frédéric Berger, Marta Galvagno,\nCinzia Panigada, Roberto Colombo, Umberto Morra di Cella,\nSimone Gottardelli, Ivan Rollet, Mario Negro, Flavio Vertui and\nCédric Fermont",authors:[{id:"165100",title:"Dr.",name:"Frédéric",surname:"Berger",fullName:"Frédéric Berger",slug:"frederic-berger",email:"frederic.berger@irstea.fr"}],book:{id:"3403",title:"Management Strategies to Adapt Alpine Space Forests to Climate Change Risks",slug:"management-strategies-to-adapt-alpine-space-forests-to-climate-change-risks",productType:{id:"1",title:"Edited Volume"}}},{id:"45245",title:"Eco-Engineering and Protection Forests Against Rockfalls and Snow Avalanches",slug:"eco-engineering-and-protection-forests-against-rockfalls-and-snow-avalanches",abstract:null,signatures:"Frédéric Berger, Luuk Dorren, Karl Kleemayr, Bernhard Maier, Spela\nPlaninsek, Christophe Bigot, Franck Bourrier, Oliver Jancke, David\nToe and Gillian Cerbu",authors:[{id:"165100",title:"Dr.",name:"Frédéric",surname:"Berger",fullName:"Frédéric Berger",slug:"frederic-berger",email:"frederic.berger@irstea.fr"}],book:{id:"3403",title:"Management Strategies to Adapt Alpine Space Forests to Climate Change Risks",slug:"management-strategies-to-adapt-alpine-space-forests-to-climate-change-risks",productType:{id:"1",title:"Edited Volume"}}},{id:"45370",title:"Description of Case Study Areas for Deriving Management Strategies to Adapt Alpine Space Forests to Climate Change Risks",slug:"description-of-case-study-areas-for-deriving-management-strategies-to-adapt-alpine-space-forests-to-",abstract:null,signatures:"Robert Jandl, Frédéric Berger, Andrej Breznikar, Giacomo Gerosa,\nHolger Veit, Gillian Cerbu and Marc Hanewinkel",authors:[{id:"165100",title:"Dr.",name:"Frédéric",surname:"Berger",fullName:"Frédéric Berger",slug:"frederic-berger",email:"frederic.berger@irstea.fr"},{id:"43539",title:"Dr.",name:"Giacomo",surname:"Gerosa",fullName:"Giacomo Gerosa",slug:"giacomo-gerosa",email:"giacomo.gerosa@unicatt.it"},{id:"129604",title:"Dr.",name:"Robert",surname:"Jandl",fullName:"Robert Jandl",slug:"robert-jandl",email:"robert.jandl@bfw.gv.at"},{id:"164924",title:"Prof.",name:"Marc",surname:"Hanewinkel",fullName:"Marc Hanewinkel",slug:"marc-hanewinkel",email:"marc.hanewinkel@wsl.ch"},{id:"164935",title:"Dr.",name:"Andrej",surname:"Breznikar",fullName:"Andrej Breznikar",slug:"andrej-breznikar",email:"andrej.breznikar@zgs.gov.si"},{id:"165320",title:"M.Sc.",name:"Gillian",surname:"Cerbu",fullName:"Gillian Cerbu",slug:"gillian-cerbu",email:"gillian.cerbu@gmail.com"},{id:"165403",title:"M.Sc.",name:"Holger",surname:"Veit",fullName:"Holger Veit",slug:"holger-veit",email:"holger.veit@forst.bwl.de"}],book:{id:"3403",title:"Management Strategies to Adapt Alpine Space Forests to Climate Change Risks",slug:"management-strategies-to-adapt-alpine-space-forests-to-climate-change-risks",productType:{id:"1",title:"Edited Volume"}}},{id:"45371",title:"Management Strategies to Adapt Alpine Space Forests to Climate Change Risks – An Introduction to the Manfred Project",slug:"management-strategies-to-adapt-alpine-space-forests-to-climate-change-risks-an-introduction-to-the-m",abstract:null,signatures:"Robert Jandl, Gillian Cerbu, Marc Hanewinkel, Fred Berger,\nGiacomo Gerosa and Silvio Schüler",authors:[{id:"165100",title:"Dr.",name:"Frédéric",surname:"Berger",fullName:"Frédéric Berger",slug:"frederic-berger",email:"frederic.berger@irstea.fr"},{id:"43539",title:"Dr.",name:"Giacomo",surname:"Gerosa",fullName:"Giacomo Gerosa",slug:"giacomo-gerosa",email:"giacomo.gerosa@unicatt.it"},{id:"129604",title:"Dr.",name:"Robert",surname:"Jandl",fullName:"Robert Jandl",slug:"robert-jandl",email:"robert.jandl@bfw.gv.at"},{id:"164924",title:"Prof.",name:"Marc",surname:"Hanewinkel",fullName:"Marc Hanewinkel",slug:"marc-hanewinkel",email:"marc.hanewinkel@wsl.ch"},{id:"157359",title:"Dr.",name:"Gillian",surname:"Cerbu",fullName:"Gillian Cerbu",slug:"gillian-cerbu",email:"Gillian.Cerbu@Forst.bwl.de"},{id:"160243",title:"Dr.",name:"Silvio",surname:"Schueler",fullName:"Silvio Schueler",slug:"silvio-schueler",email:"silvio.schueler@bfw.gv.at"}],book:{id:"3403",title:"Management Strategies to Adapt Alpine Space Forests to Climate Change Risks",slug:"management-strategies-to-adapt-alpine-space-forests-to-climate-change-risks",productType:{id:"1",title:"Edited Volume"}}}],collaborators:[{id:"43539",title:"Dr.",name:"Giacomo",surname:"Gerosa",slug:"giacomo-gerosa",fullName:"Giacomo Gerosa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/43539/images/115_n.jpg",biography:"Dr. Giacomo A. Gerosa, MD in Environmental Sciences (1997), PhD in Agricultural Ecology (2002); is ecologist and ecophysiologist with main research interests on the characterization of the exchange processes between atmosphere and biosphere, and on the effects of air pollutants on agricultural and forest ecosystems, with special regards to ozone. He is a researcher at the Department of Mathematics and Physics of the Catholic University of the Scared Heart of Brescia, Italy and professor of Ecology, Chemistry, Biology and Micrometeorology at the Faculty of Mathematics, Physics and Natural sciences of the same University. Formerly he was a professor of Ecotoxycology, Pollutants Control in Agricultural Environment, and Use and Recycle of Biomasses in Agriculture. He is a Scientific Director of CRINES (Center of Research on Air Pollution and Ecosystems) at Curno (Bergamo); Chair of the Laboratory of Ecophysiology and Environmental Physics of the Department of Mathematics and Physics at the Catholic University of SC of Brescia and President of Ecometrics Ltd., a Spin-Off company of the Catholic University of SC of Brescia. He is currently involved in many national and European research projects as a scientific reference for the Catholic University. He is the author of more than 60 papers in international peer reviewed journals and books, and referee for about 10 journals.",institutionString:null,institution:{name:"Catholic University of the Sacred Heart",institutionURL:null,country:{name:"Italy"}}},{id:"45009",title:"Dr.",name:"Angelo",surname:"Finco",slug:"angelo-finco",fullName:"Angelo Finco",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Catholic University of the Sacred Heart",institutionURL:null,country:{name:"Italy"}}},{id:"159989",title:"Dr.",name:"Luca",surname:"Cetara",slug:"luca-cetara",fullName:"Luca Cetara",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/159989/images/4819_n.jpg",biography:"I am an Economist holding a PhD in Ecology. I have been working as a researcher and consultant in the fields of sustainability, climate change and environmental policies and economics. As a lecturer I have been teaching classes and coordinating thematic courses for more than 7-years in international higher education institutions on environmental economics, green economy and business studies. I holds a remarkable experience in working on drafting studies and leading negotiations with international organisations – including the UN, national Ministries and subnational governments, in multicultural environments. I have been participating in international and regional supranational agreements and groups as government-appointed expert and conducted research and international cooperation projects, particularly in the field of climate change, finance for nature conservation, global policies for sustainable development. I authored research papers and book chapters in my fields of study and professional activity, and for dissemination purposes.",institutionString:null,institution:null},{id:"161216",title:"Dr.",name:"Bruna",surname:"Comini",slug:"bruna-comini",fullName:"Bruna Comini",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"161773",title:"Dr.",name:"Stefano",surname:"Oliveri",slug:"stefano-oliveri",fullName:"Stefano Oliveri",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"165202",title:"Prof.",name:"Niklaus",surname:"Zimmermann",slug:"niklaus-zimmermann",fullName:"Niklaus Zimmermann",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/165202/images/4420_n.jpg",biography:"...",institutionString:null,institution:{name:"Swiss Federal Institute for Forest, Snow and Landscape Research",institutionURL:null,country:{name:"Switzerland"}}},{id:"165404",title:"Dr.",name:"Marco",surname:"Pregnolato",slug:"marco-pregnolato",fullName:"Marco Pregnolato",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"165433",title:"MSc.",name:"Federico",surname:"Mannoni",slug:"federico-mannoni",fullName:"Federico Mannoni",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"165438",title:"Dr.",name:"Elena",surname:"Gagliazzi",slug:"elena-gagliazzi",fullName:"Elena Gagliazzi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"165931",title:"Mr.",name:"Giampaolo",surname:"Cocca",slug:"giampaolo-cocca",fullName:"Giampaolo Cocca",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null}]},generic:{page:{slug:"oai-pmh",title:"OAI-PMH",intro:'
As a company committed to the wider dissemination of knowledge, IntechOpen supports the OAI Metadata Harvesting Protocol (OAI-PMH Version 2.0).
',metaTitle:"OAI-PMH",metaDescription:"As a firm believer in the wider dissemination of knowledge, IntechOpen supports the OAI Metadata Harvesting Protocol (OAI-PMH Version 2.0).",metaKeywords:null,canonicalURL:"/page/oai-pmh",contentRaw:'[{"type":"htmlEditorComponent","content":"
The OAI-PMH (Open Archives Initiative Protocol for Metadata Harvesting) is used to govern the collection of metadata descriptions and enables other archives to access our database. The Protocol has been developed by the Open Archives Initiative, based on ensuring interoperability standards in order to ease and promote broader and more efficient dissemination of information within the scientific community.
\\n\\n
We have adopted the Protocol to increase the number of readers of our publications. All our Works are more widely accessible, with resulting benefits for scholars, researchers, students, libraries, universities and other academic institutions. Through this method of exposing metadata, IntechOpen enables citation indexes, scientific search engines, scholarly databases, and scientific literature collections to gather metadata from our repository and make our publications available to a broader academic audience.
\\n\\n
As a Registered Data Provider, metadata for published Books and Chapters are available via our interface at the base URL: http://mts.intechopen.com/oai/index.php
The OAI-PMH (Open Archives Initiative Protocol for Metadata Harvesting) is used to govern the collection of metadata descriptions and enables other archives to access our database. The Protocol has been developed by the Open Archives Initiative, based on ensuring interoperability standards in order to ease and promote broader and more efficient dissemination of information within the scientific community.
\n\n
We have adopted the Protocol to increase the number of readers of our publications. All our Works are more widely accessible, with resulting benefits for scholars, researchers, students, libraries, universities and other academic institutions. Through this method of exposing metadata, IntechOpen enables citation indexes, scientific search engines, scholarly databases, and scientific literature collections to gather metadata from our repository and make our publications available to a broader academic audience.
\n\n
As a Registered Data Provider, metadata for published Books and Chapters are available via our interface at the base URL: http://mts.intechopen.com/oai/index.php
A search engine for online catalogues of publications from all over the world.
\n'}]},successStories:{items:[]},authorsAndEditors:{filterParams:{},profiles:[{id:"396",title:"Dr.",name:"Vedran",middleName:null,surname:"Kordic",slug:"vedran-kordic",fullName:"Vedran Kordic",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/396/images/7281_n.png",biography:"After obtaining his Master's degree in Mechanical Engineering he continued his education at the Vienna University of Technology where he obtained his PhD degree in 2004. He worked as a researcher at the Automation and Control Institute, Faculty of Electrical Engineering, Vienna University of Technology until 2008. His studies in robotics lead him not only to a PhD degree but also inspired him to co-found and build the International Journal of Advanced Robotic Systems - world's first Open Access journal in the field of robotics.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"441",title:"Ph.D.",name:"Jaekyu",middleName:null,surname:"Park",slug:"jaekyu-park",fullName:"Jaekyu Park",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/441/images/1881_n.jpg",biography:null,institutionString:null,institution:{name:"LG Corporation (South Korea)",country:{name:"Korea, South"}}},{id:"465",title:"Dr",name:"Christian",middleName:null,surname:"Martens",slug:"christian-martens",fullName:"Christian Martens",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"479",title:"Dr.",name:"Valentina",middleName:null,surname:"Colla",slug:"valentina-colla",fullName:"Valentina Colla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/479/images/358_n.jpg",biography:null,institutionString:null,institution:{name:"Sant'Anna School of Advanced Studies",country:{name:"Italy"}}},{id:"494",title:"PhD",name:"Loris",middleName:null,surname:"Nanni",slug:"loris-nanni",fullName:"Loris Nanni",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/494/images/system/494.jpg",biography:"Loris Nanni received his Master Degree cum laude on June-2002 from the University of Bologna, and the April 26th 2006 he received his Ph.D. in Computer Engineering at DEIS, University of Bologna. On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. His research interests include pattern recognition, bioinformatics, and biometric systems (fingerprint classification and recognition, signature verification, face recognition).",institutionString:null,institution:null},{id:"496",title:"Dr.",name:"Carlos",middleName:null,surname:"Leon",slug:"carlos-leon",fullName:"Carlos Leon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Seville",country:{name:"Spain"}}},{id:"512",title:"Dr.",name:"Dayang",middleName:null,surname:"Jawawi",slug:"dayang-jawawi",fullName:"Dayang Jawawi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Technology Malaysia",country:{name:"Malaysia"}}},{id:"528",title:"Dr.",name:"Kresimir",middleName:null,surname:"Delac",slug:"kresimir-delac",fullName:"Kresimir Delac",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/528/images/system/528.jpg",biography:"K. Delac received his B.Sc.E.E. degree in 2003 and is currentlypursuing a Ph.D. degree at the University of Zagreb, Faculty of Electrical Engineering andComputing. His current research interests are digital image analysis, pattern recognition andbiometrics.",institutionString:null,institution:{name:"University of Zagreb",country:{name:"Croatia"}}},{id:"557",title:"Dr.",name:"Andon",middleName:"Venelinov",surname:"Topalov",slug:"andon-topalov",fullName:"Andon Topalov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/557/images/1927_n.jpg",biography:"Dr. Andon V. Topalov received the MSc degree in Control Engineering from the Faculty of Information Systems, Technologies, and Automation at Moscow State University of Civil Engineering (MGGU) in 1979. He then received his PhD degree in Control Engineering from the Department of Automation and Remote Control at Moscow State Mining University (MGSU), Moscow, in 1984. From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. And he has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. His current research interests are in the fields of intelligent control and robotics.",institutionString:null,institution:{name:"Technical University of Sofia",country:{name:"Bulgaria"}}},{id:"585",title:"Prof.",name:"Munir",middleName:null,surname:"Merdan",slug:"munir-merdan",fullName:"Munir Merdan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/585/images/system/585.jpg",biography:"Munir Merdan received the M.Sc. degree in mechanical engineering from the Technical University of Sarajevo, Bosnia and Herzegovina, in 2001, and the Ph.D. degree in electrical engineering from the Vienna University of Technology, Vienna, Austria, in 2009.Since 2005, he has been at the Automation and Control Institute, Vienna University of Technology, where he is currently a Senior Researcher. His research interests include the application of agent technology for achieving agile control in the manufacturing environment.",institutionString:null,institution:null},{id:"605",title:"Prof",name:"Dil",middleName:null,surname:"Hussain",slug:"dil-hussain",fullName:"Dil Hussain",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/605/images/system/605.jpg",biography:"Dr. Dil Muhammad Akbar Hussain is a professor of Electronics Engineering & Computer Science at the Department of Energy Technology, Aalborg University Denmark. Professor Akbar has a Master degree in Digital Electronics from Govt. College University, Lahore Pakistan and a P-hD degree in Control Engineering from the School of Engineering and Applied Sciences, University of Sussex United Kingdom. Aalborg University has Two Satellite Campuses, one in Copenhagen (Aalborg University Copenhagen) and the other in Esbjerg (Aalborg University Esbjerg).\n· He is a member of prestigious IEEE (Institute of Electrical and Electronics Engineers), and IAENG (International Association of Engineers) organizations. \n· He is the chief Editor of the Journal of Software Engineering.\n· He is the member of the Editorial Board of International Journal of Computer Science and Software Technology (IJCSST) and International Journal of Computer Engineering and Information Technology. \n· He is also the Editor of Communication in Computer and Information Science CCIS-20 by Springer.\n· Reviewer For Many Conferences\nHe is the lead person in making collaboration agreements between Aalborg University and many universities of Pakistan, for which the MOU’s (Memorandum of Understanding) have been signed.\nProfessor Akbar is working in Academia since 1990, he started his career as a Lab demonstrator/TA at the University of Sussex. After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. He has contributed in stochastic estimation of control area especially, in the Multiple Target Tracking and Interactive Multiple Model (IMM) research, Ball & Beam Control Problem, Robotics, Levitation Control. He has contributed in developing Algorithms for Fingerprint Matching, Computer Vision and Face Recognition. He has been supervising Pattern Recognition, Formal Languages and Distributed Processing projects for several years. He has reviewed many books on Management, Computer Science. Currently, he is an active and permanent reviewer for many international conferences and symposia and the program committee member for many international conferences.\nIn teaching he has taught the core computer science subjects like, Digital Design, Real Time Embedded System Programming, Operating Systems, Software Engineering, Data Structures, Databases, Compiler Construction. In the Engineering side, Digital Signal Processing, Computer Architecture, Electronics Devices, Digital Filtering and Engineering Management.\nApart from his Academic Interest and activities he loves sport especially, Cricket, Football, Snooker and Squash. He plays cricket for Esbjerg city in the second division team as an opener wicket keeper batsman. He is a very good player of squash but has not played squash since his arrival in Denmark.",institutionString:null,institution:null},{id:"611",title:"Prof.",name:"T",middleName:null,surname:"Nagarajan",slug:"t-nagarajan",fullName:"T Nagarajan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universiti Teknologi Petronas",country:{name:"Malaysia"}}}],filtersByRegion:[{group:"region",caption:"North America",value:1,count:6601},{group:"region",caption:"Middle and South America",value:2,count:5906},{group:"region",caption:"Africa",value:3,count:2400},{group:"region",caption:"Asia",value:4,count:12541},{group:"region",caption:"Australia and Oceania",value:5,count:1008},{group:"region",caption:"Europe",value:6,count:17561}],offset:12,limit:12,total:132763},chapterEmbeded:{data:{}},editorApplication:{success:null,errors:{}},ofsBooks:{filterParams:{"amp;sort":"dateEndThirdStepPublish",hasNoEditors:"1"},books:[{type:"book",id:"11254",title:"Optical Coherence Tomography",subtitle:null,isOpenForSubmission:!0,hash:"a958c09ceaab1fc44c1dd0a817f48c92",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11254.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11436",title:"Beauty",subtitle:null,isOpenForSubmission:!0,hash:"0e15ba86bab1a64f950318f3ab2584ed",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11436.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11438",title:"Fake News in the Era of Pandemics",subtitle:null,isOpenForSubmission:!0,hash:"bc9e4cab86c76f35cd70b39086d9b69e",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11438.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11472",title:"21st Century Slavery",subtitle:null,isOpenForSubmission:!0,hash:"b341f3fc3411ced881e43ce007a892b8",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11472.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11473",title:"Social Inequality",subtitle:null,isOpenForSubmission:!0,hash:"20307129f7fb39aa443d5449acb6a784",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11473.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11546",title:"Smart and Sustainable Transportation",subtitle:null,isOpenForSubmission:!0,hash:"e8ea27a1ff85cde00efcb6f6968c20f8",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11546.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11554",title:"Information Systems Management",subtitle:null,isOpenForSubmission:!0,hash:"3134452ff2fdec020663f241c7a9a748",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11554.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11588",title:"Autism",subtitle:null,isOpenForSubmission:!0,hash:"0c5043c6174db167599cb3f762e8bba8",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11588.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11605",title:"Bamboo",subtitle:null,isOpenForSubmission:!0,hash:"378d957561b27c86b750a9c7841a5d18",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11605.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11612",title:"Landraces",subtitle:null,isOpenForSubmission:!0,hash:"06316c41a6f6317ad2bee244dc98c6a4",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11612.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11616",title:"Foraging",subtitle:null,isOpenForSubmission:!0,hash:"955b60bb658c8d1a09dd4efc9bf6674b",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11616.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11632",title:"Updated Research on Bacteriophages",subtitle:null,isOpenForSubmission:!0,hash:"d34dfa0d5d10511184f97ddaeef9936b",slug:null,bookSignature:"",coverURL:"https://cdn.intechopen.com/books/images_new/11632.jpg",editedByType:null,editors:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],filtersByTopic:[{group:"topic",caption:"Agricultural and Biological Sciences",value:5,count:41},{group:"topic",caption:"Biochemistry, Genetics and Molecular Biology",value:6,count:12},{group:"topic",caption:"Business, Management and Economics",value:7,count:7},{group:"topic",caption:"Chemistry",value:8,count:17},{group:"topic",caption:"Computer and Information Science",value:9,count:16},{group:"topic",caption:"Earth and Planetary Sciences",value:10,count:17},{group:"topic",caption:"Engineering",value:11,count:32},{group:"topic",caption:"Environmental Sciences",value:12,count:7},{group:"topic",caption:"Immunology and Microbiology",value:13,count:11},{group:"topic",caption:"Materials Science",value:14,count:11},{group:"topic",caption:"Mathematics",value:15,count:6},{group:"topic",caption:"Medicine",value:16,count:106},{group:"topic",caption:"Nanotechnology and Nanomaterials",value:17,count:2},{group:"topic",caption:"Neuroscience",value:18,count:7},{group:"topic",caption:"Pharmacology, Toxicology and Pharmaceutical Science",value:19,count:11},{group:"topic",caption:"Physics",value:20,count:2},{group:"topic",caption:"Psychology",value:21,count:8},{group:"topic",caption:"Robotics",value:22,count:2},{group:"topic",caption:"Social Sciences",value:23,count:32},{group:"topic",caption:"Technology",value:24,count:1},{group:"topic",caption:"Veterinary Medicine and Science",value:25,count:2}],offset:12,limit:12,total:350},popularBooks:{featuredBooks:[{type:"book",id:"9974",title:"E-Learning and Digital Education in the Twenty-First Century",subtitle:null,isOpenForSubmission:!1,hash:"88b58d66e975df20425fc1dfd22d53aa",slug:"e-learning-and-digital-education-in-the-twenty-first-century",bookSignature:"M. Mahruf C. Shohel",coverURL:"https://cdn.intechopen.com/books/images_new/9974.jpg",editors:[{id:"94099",title:"Dr.",name:"M. Mahruf C.",middleName:null,surname:"Shohel",slug:"m.-mahruf-c.-shohel",fullName:"M. Mahruf C. Shohel"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11001",title:"Density Functional Theory",subtitle:"Recent Advances, New Perspectives and Applications",isOpenForSubmission:!1,hash:"82d53383af78ab41eb982086c02fb2bb",slug:"density-functional-theory-recent-advances-new-perspectives-and-applications",bookSignature:"Daniel Glossman-Mitnik",coverURL:"https://cdn.intechopen.com/books/images_new/11001.jpg",editors:[{id:"198499",title:"Dr.",name:"Daniel",middleName:null,surname:"Glossman-Mitnik",slug:"daniel-glossman-mitnik",fullName:"Daniel Glossman-Mitnik"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10251",title:"Plankton Communities",subtitle:null,isOpenForSubmission:!1,hash:"e11e441ca2d2d5f631b1b4704505cfb6",slug:"plankton-communities",bookSignature:"Leonel Pereira and Ana Marta Gonçalves",coverURL:"https://cdn.intechopen.com/books/images_new/10251.jpg",editors:[{id:"279788",title:"Dr.",name:"Leonel",middleName:null,surname:"Pereira",slug:"leonel-pereira",fullName:"Leonel Pereira"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10830",title:"Animal Feed Science and Nutrition",subtitle:"Production, Health and Environment",isOpenForSubmission:!1,hash:"79944fc8fbbaa329aed6fde388154832",slug:"animal-feed-science-and-nutrition-production-health-and-environment",bookSignature:"Amlan Kumar Patra",coverURL:"https://cdn.intechopen.com/books/images_new/10830.jpg",editors:[{id:"310962",title:"Dr.",name:"Amlan",middleName:"Kumar",surname:"Patra",slug:"amlan-patra",fullName:"Amlan Patra"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10356",title:"Natural Medicinal Plants",subtitle:null,isOpenForSubmission:!1,hash:"943e56ccaaf19ff696d25aa638ae37d6",slug:"natural-medicinal-plants",bookSignature:"Hany A. El-Shemy",coverURL:"https://cdn.intechopen.com/books/images_new/10356.jpg",editors:[{id:"54719",title:"Prof.",name:"Hany",middleName:null,surname:"El-Shemy",slug:"hany-el-shemy",fullName:"Hany El-Shemy"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11752",title:"Natural Drugs from Plants",subtitle:null,isOpenForSubmission:!1,hash:"a0a83c0822608ef7592bf16a5ed0ada4",slug:"natural-drugs-from-plants",bookSignature:"Hany A. El-Shemy",coverURL:"https://cdn.intechopen.com/books/images_new/11752.jpg",editors:[{id:"54719",title:"Prof.",name:"Hany",middleName:null,surname:"El-Shemy",slug:"hany-el-shemy",fullName:"Hany El-Shemy"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10853",title:"Recent Advances in Polynomials",subtitle:null,isOpenForSubmission:!1,hash:"9e8671bae09ccaa8b8e276c639a737fc",slug:"recent-advances-in-polynomials",bookSignature:"Kamal Shah",coverURL:"https://cdn.intechopen.com/books/images_new/10853.jpg",editors:[{id:"231748",title:"Dr.",name:"Kamal",middleName:null,surname:"Shah",slug:"kamal-shah",fullName:"Kamal Shah"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10676",title:"Recent Applications in Graph Theory",subtitle:null,isOpenForSubmission:!1,hash:"900c60742d224080732bd16bd25ccba8",slug:"recent-applications-in-graph-theory",bookSignature:"Harun Pirim",coverURL:"https://cdn.intechopen.com/books/images_new/10676.jpg",editors:[{id:"146092",title:"Dr.",name:"Harun",middleName:null,surname:"Pirim",slug:"harun-pirim",fullName:"Harun Pirim"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10903",title:"Genetically Modified Plants and Beyond",subtitle:null,isOpenForSubmission:!1,hash:"4d7ed4faab99c92cd4d676dc86501df9",slug:"genetically-modified-plants-and-beyond",bookSignature:"Idah Sithole Niang",coverURL:"https://cdn.intechopen.com/books/images_new/10903.jpg",editors:[{id:"90172",title:"Prof.",name:"Idah",middleName:null,surname:"Sithole-Niang",slug:"idah-sithole-niang",fullName:"Idah Sithole-Niang"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10904",title:"Fusarium",subtitle:"An Overview of the Genus",isOpenForSubmission:!1,hash:"49d9063e43f94bd1517d65fbc58b93c3",slug:"fusarium-an-overview-of-the-genus",bookSignature:"Seyed Mahyar Mirmajlessi",coverURL:"https://cdn.intechopen.com/books/images_new/10904.jpg",editors:[{id:"100573",title:"Dr.",name:"Seyed Mahyar",middleName:null,surname:"Mirmajlessi",slug:"seyed-mahyar-mirmajlessi",fullName:"Seyed Mahyar Mirmajlessi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10871",title:"Computed-Tomography (CT) Scan",subtitle:null,isOpenForSubmission:!1,hash:"966d8cf74fa27eea1b9cbc9a6ee94993",slug:"computed-tomography-ct-scan",bookSignature:"Reda R. Gharieb",coverURL:"https://cdn.intechopen.com/books/images_new/10871.jpg",editors:[{id:"225387",title:"Prof.",name:"Reda R.",middleName:"R.",surname:"Gharieb",slug:"reda-r.-gharieb",fullName:"Reda R. Gharieb"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11196",title:"New Updates in E-Learning",subtitle:null,isOpenForSubmission:!1,hash:"6afaadf68e2a0a4b370ac5ceb5ca89c6",slug:"new-updates-in-e-learning",bookSignature:"Eduard Babulak",coverURL:"https://cdn.intechopen.com/books/images_new/11196.jpg",editors:[{id:"10086",title:"Prof.",name:"Eduard",middleName:null,surname:"Babulak",slug:"eduard-babulak",fullName:"Eduard Babulak"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],offset:12,limit:12,total:4387},hotBookTopics:{hotBooks:[],offset:0,limit:12,total:null},publish:{},publishingProposal:{success:null,errors:{}},books:{featuredBooks:[{type:"book",id:"9974",title:"E-Learning and Digital Education in the Twenty-First Century",subtitle:null,isOpenForSubmission:!1,hash:"88b58d66e975df20425fc1dfd22d53aa",slug:"e-learning-and-digital-education-in-the-twenty-first-century",bookSignature:"M. Mahruf C. Shohel",coverURL:"https://cdn.intechopen.com/books/images_new/9974.jpg",publishedDate:"May 18th 2022",numberOfDownloads:3340,editors:[{id:"94099",title:"Dr.",name:"M. Mahruf C.",middleName:null,surname:"Shohel",slug:"m.-mahruf-c.-shohel",fullName:"M. Mahruf C. Shohel"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11001",title:"Density Functional Theory",subtitle:"Recent Advances, New Perspectives and Applications",isOpenForSubmission:!1,hash:"82d53383af78ab41eb982086c02fb2bb",slug:"density-functional-theory-recent-advances-new-perspectives-and-applications",bookSignature:"Daniel Glossman-Mitnik",coverURL:"https://cdn.intechopen.com/books/images_new/11001.jpg",publishedDate:"May 18th 2022",numberOfDownloads:1845,editors:[{id:"198499",title:"Dr.",name:"Daniel",middleName:null,surname:"Glossman-Mitnik",slug:"daniel-glossman-mitnik",fullName:"Daniel Glossman-Mitnik"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10251",title:"Plankton Communities",subtitle:null,isOpenForSubmission:!1,hash:"e11e441ca2d2d5f631b1b4704505cfb6",slug:"plankton-communities",bookSignature:"Leonel Pereira and Ana Marta Gonçalves",coverURL:"https://cdn.intechopen.com/books/images_new/10251.jpg",publishedDate:"May 18th 2022",numberOfDownloads:1096,editors:[{id:"279788",title:"Dr.",name:"Leonel",middleName:null,surname:"Pereira",slug:"leonel-pereira",fullName:"Leonel Pereira"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10830",title:"Animal Feed Science and Nutrition",subtitle:"Production, Health and Environment",isOpenForSubmission:!1,hash:"79944fc8fbbaa329aed6fde388154832",slug:"animal-feed-science-and-nutrition-production-health-and-environment",bookSignature:"Amlan Kumar Patra",coverURL:"https://cdn.intechopen.com/books/images_new/10830.jpg",publishedDate:"May 18th 2022",numberOfDownloads:995,editors:[{id:"310962",title:"Dr.",name:"Amlan",middleName:"Kumar",surname:"Patra",slug:"amlan-patra",fullName:"Amlan Patra"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10356",title:"Natural Medicinal Plants",subtitle:null,isOpenForSubmission:!1,hash:"943e56ccaaf19ff696d25aa638ae37d6",slug:"natural-medicinal-plants",bookSignature:"Hany A. El-Shemy",coverURL:"https://cdn.intechopen.com/books/images_new/10356.jpg",publishedDate:"May 11th 2022",numberOfDownloads:3791,editors:[{id:"54719",title:"Prof.",name:"Hany",middleName:null,surname:"El-Shemy",slug:"hany-el-shemy",fullName:"Hany El-Shemy"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11752",title:"Natural Drugs from Plants",subtitle:null,isOpenForSubmission:!1,hash:"a0a83c0822608ef7592bf16a5ed0ada4",slug:"natural-drugs-from-plants",bookSignature:"Hany A. El-Shemy",coverURL:"https://cdn.intechopen.com/books/images_new/11752.jpg",publishedDate:"May 11th 2022",numberOfDownloads:2982,editors:[{id:"54719",title:"Prof.",name:"Hany",middleName:null,surname:"El-Shemy",slug:"hany-el-shemy",fullName:"Hany El-Shemy"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10853",title:"Recent Advances in Polynomials",subtitle:null,isOpenForSubmission:!1,hash:"9e8671bae09ccaa8b8e276c639a737fc",slug:"recent-advances-in-polynomials",bookSignature:"Kamal Shah",coverURL:"https://cdn.intechopen.com/books/images_new/10853.jpg",publishedDate:"May 18th 2022",numberOfDownloads:559,editors:[{id:"231748",title:"Dr.",name:"Kamal",middleName:null,surname:"Shah",slug:"kamal-shah",fullName:"Kamal Shah"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10676",title:"Recent Applications in Graph Theory",subtitle:null,isOpenForSubmission:!1,hash:"900c60742d224080732bd16bd25ccba8",slug:"recent-applications-in-graph-theory",bookSignature:"Harun Pirim",coverURL:"https://cdn.intechopen.com/books/images_new/10676.jpg",publishedDate:"May 18th 2022",numberOfDownloads:546,editors:[{id:"146092",title:"Dr.",name:"Harun",middleName:null,surname:"Pirim",slug:"harun-pirim",fullName:"Harun Pirim"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10903",title:"Genetically Modified Plants and Beyond",subtitle:null,isOpenForSubmission:!1,hash:"4d7ed4faab99c92cd4d676dc86501df9",slug:"genetically-modified-plants-and-beyond",bookSignature:"Idah Sithole Niang",coverURL:"https://cdn.intechopen.com/books/images_new/10903.jpg",publishedDate:"May 18th 2022",numberOfDownloads:539,editors:[{id:"90172",title:"Prof.",name:"Idah",middleName:null,surname:"Sithole-Niang",slug:"idah-sithole-niang",fullName:"Idah Sithole-Niang"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10904",title:"Fusarium",subtitle:"An Overview of the Genus",isOpenForSubmission:!1,hash:"49d9063e43f94bd1517d65fbc58b93c3",slug:"fusarium-an-overview-of-the-genus",bookSignature:"Seyed Mahyar Mirmajlessi",coverURL:"https://cdn.intechopen.com/books/images_new/10904.jpg",publishedDate:"May 18th 2022",numberOfDownloads:535,editors:[{id:"100573",title:"Dr.",name:"Seyed Mahyar",middleName:null,surname:"Mirmajlessi",slug:"seyed-mahyar-mirmajlessi",fullName:"Seyed Mahyar Mirmajlessi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],latestBooks:[{type:"book",id:"10251",title:"Plankton Communities",subtitle:null,isOpenForSubmission:!1,hash:"e11e441ca2d2d5f631b1b4704505cfb6",slug:"plankton-communities",bookSignature:"Leonel Pereira and Ana Marta Gonçalves",coverURL:"https://cdn.intechopen.com/books/images_new/10251.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"279788",title:"Dr.",name:"Leonel",middleName:null,surname:"Pereira",slug:"leonel-pereira",fullName:"Leonel Pereira"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10830",title:"Animal Feed Science and Nutrition",subtitle:"Production, Health and Environment",isOpenForSubmission:!1,hash:"79944fc8fbbaa329aed6fde388154832",slug:"animal-feed-science-and-nutrition-production-health-and-environment",bookSignature:"Amlan Kumar Patra",coverURL:"https://cdn.intechopen.com/books/images_new/10830.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"310962",title:"Dr.",name:"Amlan",middleName:"Kumar",surname:"Patra",slug:"amlan-patra",fullName:"Amlan Patra"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10853",title:"Recent Advances in Polynomials",subtitle:null,isOpenForSubmission:!1,hash:"9e8671bae09ccaa8b8e276c639a737fc",slug:"recent-advances-in-polynomials",bookSignature:"Kamal Shah",coverURL:"https://cdn.intechopen.com/books/images_new/10853.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"231748",title:"Dr.",name:"Kamal",middleName:null,surname:"Shah",slug:"kamal-shah",fullName:"Kamal Shah"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10871",title:"Computed-Tomography (CT) Scan",subtitle:null,isOpenForSubmission:!1,hash:"966d8cf74fa27eea1b9cbc9a6ee94993",slug:"computed-tomography-ct-scan",bookSignature:"Reda R. Gharieb",coverURL:"https://cdn.intechopen.com/books/images_new/10871.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"225387",title:"Prof.",name:"Reda R.",middleName:"R.",surname:"Gharieb",slug:"reda-r.-gharieb",fullName:"Reda R. Gharieb"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10903",title:"Genetically Modified Plants and Beyond",subtitle:null,isOpenForSubmission:!1,hash:"4d7ed4faab99c92cd4d676dc86501df9",slug:"genetically-modified-plants-and-beyond",bookSignature:"Idah Sithole Niang",coverURL:"https://cdn.intechopen.com/books/images_new/10903.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"90172",title:"Prof.",name:"Idah",middleName:null,surname:"Sithole-Niang",slug:"idah-sithole-niang",fullName:"Idah Sithole-Niang"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10904",title:"Fusarium",subtitle:"An Overview of the Genus",isOpenForSubmission:!1,hash:"49d9063e43f94bd1517d65fbc58b93c3",slug:"fusarium-an-overview-of-the-genus",bookSignature:"Seyed Mahyar Mirmajlessi",coverURL:"https://cdn.intechopen.com/books/images_new/10904.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"100573",title:"Dr.",name:"Seyed Mahyar",middleName:null,surname:"Mirmajlessi",slug:"seyed-mahyar-mirmajlessi",fullName:"Seyed Mahyar Mirmajlessi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10654",title:"Brain-Computer Interface",subtitle:null,isOpenForSubmission:!1,hash:"a5308884068cc53ed31c6baba756857f",slug:"brain-computer-interface",bookSignature:"Vahid Asadpour",coverURL:"https://cdn.intechopen.com/books/images_new/10654.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"165328",title:"Dr.",name:"Vahid",middleName:null,surname:"Asadpour",slug:"vahid-asadpour",fullName:"Vahid Asadpour"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10676",title:"Recent Applications in Graph Theory",subtitle:null,isOpenForSubmission:!1,hash:"900c60742d224080732bd16bd25ccba8",slug:"recent-applications-in-graph-theory",bookSignature:"Harun Pirim",coverURL:"https://cdn.intechopen.com/books/images_new/10676.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"146092",title:"Dr.",name:"Harun",middleName:null,surname:"Pirim",slug:"harun-pirim",fullName:"Harun Pirim"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11196",title:"New Updates in E-Learning",subtitle:null,isOpenForSubmission:!1,hash:"6afaadf68e2a0a4b370ac5ceb5ca89c6",slug:"new-updates-in-e-learning",bookSignature:"Eduard Babulak",coverURL:"https://cdn.intechopen.com/books/images_new/11196.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"10086",title:"Prof.",name:"Eduard",middleName:null,surname:"Babulak",slug:"eduard-babulak",fullName:"Eduard Babulak"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9974",title:"E-Learning and Digital Education in the Twenty-First Century",subtitle:null,isOpenForSubmission:!1,hash:"88b58d66e975df20425fc1dfd22d53aa",slug:"e-learning-and-digital-education-in-the-twenty-first-century",bookSignature:"M. Mahruf C. Shohel",coverURL:"https://cdn.intechopen.com/books/images_new/9974.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"94099",title:"Dr.",name:"M. Mahruf C.",middleName:null,surname:"Shohel",slug:"m.-mahruf-c.-shohel",fullName:"M. Mahruf C. Shohel"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},subject:{topic:{id:"377",title:"Seed Technology",slug:"agricultural-and-biological-sciences-plant-biology-seed-technology",parent:{id:"41",title:"Plant Biology",slug:"agricultural-and-biological-sciences-plant-biology"},numberOfBooks:1,numberOfSeries:0,numberOfAuthorsAndEditors:24,numberOfWosCitations:33,numberOfCrossrefCitations:0,numberOfDimensionsCitations:0,videoUrl:null,fallbackUrl:null,description:null},booksByTopicFilter:{topicId:"377",sort:"-publishedDate",limit:12,offset:0},booksByTopicCollection:[{type:"book",id:"868",title:"Oilseeds",subtitle:null,isOpenForSubmission:!1,hash:"645016fb107c6d746ea750aad7493617",slug:"oilseeds",bookSignature:"Uduak G. Akpan",coverURL:"https://cdn.intechopen.com/books/images_new/868.jpg",editedByType:"Edited by",editors:[{id:"82191",title:"Dr.",name:"Uduak G.",middleName:null,surname:"Akpan",slug:"uduak-g.-akpan",fullName:"Uduak G. Akpan"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],booksByTopicTotal:1,seriesByTopicCollection:[],seriesByTopicTotal:0,mostCitedChapters:[{id:"37644",doi:"10.5772/32721",title:"Prospects for Transgenic and Molecular Breeding for Cold Tolerance in Canola (Brassica napus L.)",slug:"prospects-for-transgenic-and-molecular-breeding-for-cold-tolerance-in-canola-brassica-napus-l-",totalDownloads:2890,totalCrossrefCites:0,totalDimensionsCites:0,abstract:null,book:{id:"868",slug:"oilseeds",title:"Oilseeds",fullTitle:"Oilseeds"},signatures:"Anthony O. Ananga, Ernst Cebert, Joel W. Ochieng, Suresh Kumar, Devaiah Kambiranda, Hemanth Vasanthaiah, Violetka Tsolova, Zachary Senwo, Koffi Konan and Felicia N. Anike",authors:[{id:"65633",title:"Dr.",name:"Hemanth",middleName:"Kn",surname:"Vasanthaiah",slug:"hemanth-vasanthaiah",fullName:"Hemanth Vasanthaiah"},{id:"74792",title:"Dr.",name:"Joel W.",middleName:null,surname:"Ochieng",slug:"joel-w.-ochieng",fullName:"Joel W. Ochieng"},{id:"92458",title:"Dr.",name:"Ernst",middleName:null,surname:"Cebert",slug:"ernst-cebert",fullName:"Ernst Cebert"},{id:"126149",title:"Dr.",name:"Anthony",middleName:null,surname:"Ananga",slug:"anthony-ananga",fullName:"Anthony Ananga"},{id:"136830",title:"Dr.",name:"Devaiah",middleName:null,surname:"Kambiranda",slug:"devaiah-kambiranda",fullName:"Devaiah Kambiranda"},{id:"137410",title:"Dr.",name:"Suresh",middleName:null,surname:"Kumar",slug:"suresh-kumar",fullName:"Suresh Kumar"},{id:"137412",title:"Dr.",name:"Violetka",middleName:null,surname:"Tsolova",slug:"violetka-tsolova",fullName:"Violetka Tsolova"},{id:"137413",title:"Dr.",name:"Zachary",middleName:null,surname:"Senwo",slug:"zachary-senwo",fullName:"Zachary Senwo"},{id:"137414",title:"Dr.",name:"Koffi",middleName:null,surname:"Konan",slug:"koffi-konan",fullName:"Koffi Konan"},{id:"137415",title:"Dr.",name:"Felicia",middleName:null,surname:"Anike",slug:"felicia-anike",fullName:"Felicia Anike"}]},{id:"37645",doi:"10.5772/30699",title:"Oil Presses",slug:"oil-presses",totalDownloads:4379,totalCrossrefCites:0,totalDimensionsCites:0,abstract:null,book:{id:"868",slug:"oilseeds",title:"Oilseeds",fullTitle:"Oilseeds"},signatures:"Anna Leticia M. Turtelli Pighinelli and Rossano Gambetta",authors:[{id:"83832",title:"Prof.",name:"Anna Leticia",middleName:"Montenegro Turtelli",surname:"Pighinelli",slug:"anna-leticia-pighinelli",fullName:"Anna Leticia Pighinelli"},{id:"99563",title:"Dr.",name:"Rossano",middleName:null,surname:"Gambetta",slug:"rossano-gambetta",fullName:"Rossano Gambetta"}]},{id:"37646",doi:"10.5772/30625",title:"Effect of Seed-Placed Ammonium Sulfate and Monoammonium Phosphate on Germination, Emergence and Early Plant Biomass Production of Brassicae Oilseed Crops",slug:"effect-of-seed-placed-ammonium-sulfate-and-monoammonium-phosphate-on-germination-emergence-and-early",totalDownloads:3434,totalCrossrefCites:0,totalDimensionsCites:0,abstract:null,book:{id:"868",slug:"oilseeds",title:"Oilseeds",fullTitle:"Oilseeds"},signatures:"P. Qian, R. Urton, J. J. Schoenau, T. King, C. Fatteicher and C. Grant",authors:[{id:"83382",title:"Dr.",name:"Peiyuan",middleName:null,surname:"Qian",slug:"peiyuan-qian",fullName:"Peiyuan Qian"}]},{id:"37647",doi:"10.5772/31637",title:"Nitrogen Efficiency in Oilseed Rape and Its Physiological Mechanism",slug:"nitrogen-efficiency-in-oilseed-rape-and-its-physiological-mechanism",totalDownloads:1786,totalCrossrefCites:0,totalDimensionsCites:0,abstract:null,book:{id:"868",slug:"oilseeds",title:"Oilseeds",fullTitle:"Oilseeds"},signatures:"Zhen-hua Zhang, Hai-xing Song and Chunyun Guan",authors:[{id:"88068",title:"Prof.",name:"Hai-Xing",middleName:null,surname:"Song",slug:"hai-xing-song",fullName:"Hai-Xing Song"},{id:"111533",title:"Dr.",name:"Zhen-Hua",middleName:null,surname:"Zhang",slug:"zhen-hua-zhang",fullName:"Zhen-Hua Zhang"}]},{id:"37648",doi:"10.5772/32941",title:"Sesame Seed",slug:"sesame-seed",totalDownloads:21195,totalCrossrefCites:0,totalDimensionsCites:0,abstract:null,book:{id:"868",slug:"oilseeds",title:"Oilseeds",fullTitle:"Oilseeds"},signatures:"T. Y. Tunde-Akintunde, M. O. Oke and B. O. Akintunde",authors:[{id:"88229",title:"Dr.",name:"Toyosi",middleName:null,surname:"Tunde-Akintunde",slug:"toyosi-tunde-akintunde",fullName:"Toyosi Tunde-Akintunde"},{id:"93291",title:"Mr.",name:"Babatunde",middleName:null,surname:"Akintunde",slug:"babatunde-akintunde",fullName:"Babatunde Akintunde"},{id:"93429",title:"Dr.",name:"Moruf",middleName:"Olanrewaju",surname:"Oke",slug:"moruf-oke",fullName:"Moruf Oke"}]}],mostDownloadedChaptersLast30Days:[{id:"37648",title:"Sesame Seed",slug:"sesame-seed",totalDownloads:21202,totalCrossrefCites:0,totalDimensionsCites:0,abstract:null,book:{id:"868",slug:"oilseeds",title:"Oilseeds",fullTitle:"Oilseeds"},signatures:"T. Y. Tunde-Akintunde, M. O. Oke and B. O. Akintunde",authors:[{id:"88229",title:"Dr.",name:"Toyosi",middleName:null,surname:"Tunde-Akintunde",slug:"toyosi-tunde-akintunde",fullName:"Toyosi Tunde-Akintunde"},{id:"93291",title:"Mr.",name:"Babatunde",middleName:null,surname:"Akintunde",slug:"babatunde-akintunde",fullName:"Babatunde Akintunde"},{id:"93429",title:"Dr.",name:"Moruf",middleName:"Olanrewaju",surname:"Oke",slug:"moruf-oke",fullName:"Moruf Oke"}]},{id:"37650",title:"Oilseed Pests",slug:"oilseed-pests",totalDownloads:6645,totalCrossrefCites:0,totalDimensionsCites:0,abstract:null,book:{id:"868",slug:"oilseeds",title:"Oilseeds",fullTitle:"Oilseeds"},signatures:"Masumeh Ziaee",authors:[{id:"93923",title:"Dr.",name:"Masumeh",middleName:null,surname:"Ziaee",slug:"masumeh-ziaee",fullName:"Masumeh Ziaee"}]},{id:"37646",title:"Effect of Seed-Placed Ammonium Sulfate and Monoammonium Phosphate on Germination, Emergence and Early Plant Biomass Production of Brassicae Oilseed Crops",slug:"effect-of-seed-placed-ammonium-sulfate-and-monoammonium-phosphate-on-germination-emergence-and-early",totalDownloads:3440,totalCrossrefCites:0,totalDimensionsCites:0,abstract:null,book:{id:"868",slug:"oilseeds",title:"Oilseeds",fullTitle:"Oilseeds"},signatures:"P. Qian, R. Urton, J. J. Schoenau, T. King, C. Fatteicher and C. Grant",authors:[{id:"83382",title:"Dr.",name:"Peiyuan",middleName:null,surname:"Qian",slug:"peiyuan-qian",fullName:"Peiyuan Qian"}]},{id:"37644",title:"Prospects for Transgenic and Molecular Breeding for Cold Tolerance in Canola (Brassica napus L.)",slug:"prospects-for-transgenic-and-molecular-breeding-for-cold-tolerance-in-canola-brassica-napus-l-",totalDownloads:2891,totalCrossrefCites:0,totalDimensionsCites:0,abstract:null,book:{id:"868",slug:"oilseeds",title:"Oilseeds",fullTitle:"Oilseeds"},signatures:"Anthony O. Ananga, Ernst Cebert, Joel W. Ochieng, Suresh Kumar, Devaiah Kambiranda, Hemanth Vasanthaiah, Violetka Tsolova, Zachary Senwo, Koffi Konan and Felicia N. Anike",authors:[{id:"65633",title:"Dr.",name:"Hemanth",middleName:"Kn",surname:"Vasanthaiah",slug:"hemanth-vasanthaiah",fullName:"Hemanth Vasanthaiah"},{id:"74792",title:"Dr.",name:"Joel W.",middleName:null,surname:"Ochieng",slug:"joel-w.-ochieng",fullName:"Joel W. Ochieng"},{id:"92458",title:"Dr.",name:"Ernst",middleName:null,surname:"Cebert",slug:"ernst-cebert",fullName:"Ernst Cebert"},{id:"126149",title:"Dr.",name:"Anthony",middleName:null,surname:"Ananga",slug:"anthony-ananga",fullName:"Anthony Ananga"},{id:"136830",title:"Dr.",name:"Devaiah",middleName:null,surname:"Kambiranda",slug:"devaiah-kambiranda",fullName:"Devaiah Kambiranda"},{id:"137410",title:"Dr.",name:"Suresh",middleName:null,surname:"Kumar",slug:"suresh-kumar",fullName:"Suresh Kumar"},{id:"137412",title:"Dr.",name:"Violetka",middleName:null,surname:"Tsolova",slug:"violetka-tsolova",fullName:"Violetka Tsolova"},{id:"137413",title:"Dr.",name:"Zachary",middleName:null,surname:"Senwo",slug:"zachary-senwo",fullName:"Zachary Senwo"},{id:"137414",title:"Dr.",name:"Koffi",middleName:null,surname:"Konan",slug:"koffi-konan",fullName:"Koffi Konan"},{id:"137415",title:"Dr.",name:"Felicia",middleName:null,surname:"Anike",slug:"felicia-anike",fullName:"Felicia Anike"}]},{id:"37649",title:"Adaptability and Sustainable Management of High-Erucic Brassicaceae in Mediterranean Environment",slug:"adaptability-and-sustainable-management-of-high-erucic-brassicaceae-in-mediterranean-environment",totalDownloads:2370,totalCrossrefCites:0,totalDimensionsCites:0,abstract:null,book:{id:"868",slug:"oilseeds",title:"Oilseeds",fullTitle:"Oilseeds"},signatures:"Federica Zanetti, Giuliano Mosca, Enrico Rampin and Teofilo Vamerali",authors:[{id:"92609",title:"Dr.",name:"Federica",middleName:null,surname:"Zanetti",slug:"federica-zanetti",fullName:"Federica Zanetti"},{id:"98349",title:"Prof.",name:"Giuliano",middleName:null,surname:"Mosca",slug:"giuliano-mosca",fullName:"Giuliano Mosca"},{id:"98350",title:"Dr.",name:"Enrico",middleName:null,surname:"Rampin",slug:"enrico-rampin",fullName:"Enrico Rampin"},{id:"98351",title:"Prof.",name:"Teofilo",middleName:null,surname:"Vamerali",slug:"teofilo-vamerali",fullName:"Teofilo Vamerali"}]}],onlineFirstChaptersFilter:{topicId:"377",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:98,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:287,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:10,numberOfPublishedChapters:103,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:10,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"24",title:"Sustainable Development",doi:"10.5772/intechopen.100361",issn:null,scope:"
\r\n\tTransforming our World: the 2030 Agenda for Sustainable Development endorsed by United Nations and 193 Member States, came into effect on Jan 1, 2016, to guide decision making and actions to the year 2030 and beyond. Central to this Agenda are 17 Goals, 169 associated targets and over 230 indicators that are reviewed annually. The vision envisaged in the implementation of the SDGs is centered on the five Ps: People, Planet, Prosperity, Peace and Partnership. This call for renewed focused efforts ensure we have a safe and healthy planet for current and future generations.
\r\n
\r\n\t
\r\n
\r\n\tThis Series focuses on covering research and applied research involving the five Ps through the following topics:
\r\n
\r\n\t
\r\n
\r\n\t1. Sustainable Economy and Fair Society that relates to SDG 1 on No Poverty, SDG 2 on Zero Hunger, SDG 8 on Decent Work and Economic Growth, SDG 10 on Reduced Inequalities, SDG 12 on Responsible Consumption and Production, and SDG 17 Partnership for the Goals
\r\n
\r\n\t
\r\n
\r\n\t2. Health and Wellbeing focusing on SDG 3 on Good Health and Wellbeing and SDG 6 on Clean Water and Sanitation
\r\n
\r\n\t
\r\n
\r\n\t3. Inclusivity and Social Equality involving SDG 4 on Quality Education, SDG 5 on Gender Equality, and SDG 16 on Peace, Justice and Strong Institutions
\r\n
\r\n\t
\r\n
\r\n\t4. Climate Change and Environmental Sustainability comprising SDG 13 on Climate Action, SDG 14 on Life Below Water, and SDG 15 on Life on Land
\r\n
\r\n\t
\r\n
\r\n\t5. Urban Planning and Environmental Management embracing SDG 7 on Affordable Clean Energy, SDG 9 on Industry, Innovation and Infrastructure, and SDG 11 on Sustainable Cities and Communities.
\r\n
\r\n\t
\r\n
\r\n\tThe series also seeks to support the use of cross cutting SDGs, as many of the goals listed above, targets and indicators are all interconnected to impact our lives and the decisions we make on a daily basis, making them impossible to tie to a single topic.
",coverUrl:"https://cdn.intechopen.com/series/covers/24.jpg",latestPublicationDate:"May 19th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:0,editor:{id:"262440",title:"Prof.",name:"Usha",middleName:null,surname:"Iyer-Raniga",slug:"usha-iyer-raniga",fullName:"Usha Iyer-Raniga",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRYSXQA4/Profile_Picture_2022-02-28T13:55:36.jpeg",biography:"Usha Iyer-Raniga is a professor in the School of Property and Construction Management at RMIT University. Usha co-leads the One Planet Network’s Sustainable Buildings and Construction Programme (SBC), a United Nations 10 Year Framework of Programmes on Sustainable Consumption and Production (UN 10FYP SCP) aligned with Sustainable Development Goal 12. The work also directly impacts SDG 11 on Sustainable Cities and Communities. She completed her undergraduate degree as an architect before obtaining her Masters degree from Canada and her Doctorate in Australia. Usha has been a keynote speaker as well as an invited speaker at national and international conferences, seminars and workshops. Her teaching experience includes teaching in Asian countries. She has advised Austrade, APEC, national, state and local governments. She serves as a reviewer and a member of the scientific committee for national and international refereed journals and refereed conferences. She is on the editorial board for refereed journals and has worked on Special Issues. Usha has served and continues to serve on the Boards of several not-for-profit organisations and she has also served as panel judge for a number of awards including the Premiers Sustainability Award in Victoria and the International Green Gown Awards. Usha has published over 100 publications, including research and consulting reports. Her publications cover a wide range of scientific and technical research publications that include edited books, book chapters, refereed journals, refereed conference papers and reports for local, state and federal government clients. She has also produced podcasts for various organisations and participated in media interviews. She has received state, national and international funding worth over USD $25 million. Usha has been awarded the Quarterly Franklin Membership by London Journals Press (UK). Her biography has been included in the Marquis Who's Who in the World® 2018, 2016 (33rd Edition), along with approximately 55,000 of the most accomplished men and women from around the world, including luminaries as U.N. Secretary-General Ban Ki-moon. In 2017, Usha was awarded the Marquis Who’s Who Lifetime Achiever Award.",institutionString:null,institution:{name:"RMIT University",institutionURL:null,country:{name:"Australia"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:5,paginationItems:[{id:"91",title:"Sustainable Economy and Fair Society",coverUrl:"https://cdn.intechopen.com/series_topics/covers/91.jpg",isOpenForSubmission:!0,editor:{id:"181603",title:"Dr.",name:"Antonella",middleName:null,surname:"Petrillo",slug:"antonella-petrillo",fullName:"Antonella Petrillo",profilePictureURL:"https://mts.intechopen.com/storage/users/181603/images/system/181603.jpg",biography:"Antonella Petrillo is a Professor at the Department of Engineering of the University of Naples “Parthenope”, Italy. She received her Ph.D. in Mechanical Engineering from the University of Cassino. Her research interests include multi-criteria decision analysis, industrial plant, logistics, manufacturing and safety. She serves as an Associate Editor for the International Journal of the Analytic Hierarchy Process. She is a member of AHP Academy and a member of several editorial boards. She has over 160 Scientific Publications in International Journals and Conferences and she is the author of 5 books on Innovation and Decision Making in Industrial Applications and Engineering.",institutionString:null,institution:{name:"Parthenope University of Naples",institutionURL:null,country:{name:"Italy"}}},editorTwo:null,editorThree:null},{id:"92",title:"Health and Wellbeing",coverUrl:"https://cdn.intechopen.com/series_topics/covers/92.jpg",isOpenForSubmission:!0,editor:{id:"348225",title:"Prof.",name:"Ann",middleName:null,surname:"Hemingway",slug:"ann-hemingway",fullName:"Ann Hemingway",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035LZFoQAO/Profile_Picture_2022-04-11T14:55:40.jpg",biography:"Professor Hemingway is a public health researcher, Bournemouth University, undertaking international and UK research focused on reducing inequalities in health outcomes for marginalised and excluded populations and more recently focused on equine assisted interventions.",institutionString:null,institution:{name:"Bournemouth University",institutionURL:null,country:{name:"United Kingdom"}}},editorTwo:null,editorThree:null},{id:"93",title:"Inclusivity and Social Equity",coverUrl:"https://cdn.intechopen.com/series_topics/covers/93.jpg",isOpenForSubmission:!0,editor:{id:"210060",title:"Prof. Dr.",name:"Ebba",middleName:null,surname:"Ossiannilsson",slug:"ebba-ossiannilsson",fullName:"Ebba Ossiannilsson",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6LkBQAU/Profile_Picture_2022-02-28T13:31:48.png",biography:'Professor Dr. Ebba Ossiannilsson is an independent researcher, expert, consultant, quality auditor and influencer in the fields of open, flexible online and distance learning (OFDL) and the "new normal". Her focus is on quality, innovation, leadership, and personalised learning. She works primarily at the strategic and policy levels, both nationally and internationally, and with key international organisations. She is committed to promoting and improving OFDL in the context of SDG4 and the future of education. Ossiannilsson has more than 20 years of experience in her current field, but more than 40 years in the education sector. She works as a reviewer and expert for the European Commission and collaborates with the Joint Research Centre for Quality in Open Education. Ossiannilsson also collaborates with ITCILO and ICoBC (International Council on Badges and Credentials). She is a member of the ICDE Board of Directors and has previously served on the boards of EDEN and EUCEN. Ossiannilsson is a quality expert and reviewer for ICDE, EDEN and the EADTU. She chairs the ICDE OER Advocacy Committee and is a member of the ICDE Quality Network. She is regularly invited as a keynote speaker at conferences. She is a guest editor for several special issues and a member of the editorial board of several scientific journals. She has published more than 200 articles and is currently working on book projects in the field of OFDL. Ossiannilsson is a visiting professor at several international universities and was recently appointed Professor and Research Fellow at Victoria University of Wellington, NZ. Ossiannilsson has been awarded the following fellowships: EDEN Fellows, EDEN Council of Fellows, and Open Education Europe. She is a ICDE OER Ambassador, Open Education Europe Ambassador, GIZ Ambassador for Quality in Digital Learning, and part of the Globe-Community of Digital Learning and Champion of SPARC Europe. On a national level, she is a quality developer at the Swedish Institute for Standards (SIS) and for ISO. She is a member of the Digital Skills and Jobs Coalition Sweden and Vice President of the Swedish Association for Distance Education. She is currently working on a government initiative on quality in distance education at the National Council for Higher Education. She holds a Ph.D. from the University of Oulu, Finland.',institutionString:"Swedish Association for Distance Education, Sweden",institution:null},editorTwo:null,editorThree:null},{id:"94",title:"Climate Change and Environmental Sustainability",coverUrl:"https://cdn.intechopen.com/series_topics/covers/94.jpg",isOpenForSubmission:!1,editor:null,editorTwo:null,editorThree:null},{id:"95",title:"Urban Planning and Environmental Management",coverUrl:"https://cdn.intechopen.com/series_topics/covers/95.jpg",isOpenForSubmission:!0,editor:{id:"181079",title:"Dr.",name:"Christoph",middleName:null,surname:"Lüthi",slug:"christoph-luthi",fullName:"Christoph Lüthi",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRHSqQAO/Profile_Picture_2022-04-12T15:51:33.png",biography:"Dr. Christoph Lüthi is an urban infrastructure planner with over 25 years of experience in planning and design of urban infrastructure in middle and low-income countries. He holds a Master’s Degree in Urban Development Planning from the University College of London (UCL), and a Ph.D. in Urban Planning & Engineering from TU Berlin. He has conducted applied research on urban planning and infrastructure issues in over 20 countries in Africa and Asia. In 2005 he joined Eawag-Sandec as Leader of the Strategic Environmental Sanitation Planning Group. Since 2015 he heads the research department Sanitation, Water and Solid Waste for Development (Sandec) at the Swiss Federal Institute of Aquatic Research and Technology (Eawag).",institutionString:"Swiss Federal Institute of Aquatic Science and Technology, Switzerland",institution:null},editorTwo:{id:"290571",title:"Dr.",name:"Rui Alexandre",middleName:null,surname:"Castanho",slug:"rui-alexandre-castanho",fullName:"Rui Alexandre Castanho",profilePictureURL:"https://mts.intechopen.com/storage/users/290571/images/system/290571.jpg",biography:"Rui Alexandre Castanho has a master\\'s degree in Planning, Audit, and Control in Urban Green Spaces and an international Ph.D. in Sustainable Planning in Borderlands. Currently, he is a professor at WSB University, Poland, and a visiting professor at the University of Johannesburg, South Africa. Dr. Castanho is a post-doc researcher on the GREAT Project, University of Azores, Ponta Delgada, Portugal. He collaborates with the Environmental Resources Analysis Research Group (ARAM), University of Extremadura (UEx), Spain; VALORIZA - Research Center for the Enhancement of Endogenous Resources, Polytechnic Institute of Portalegre (IPP), Portugal; Centre for Tourism Research, Development and Innovation (CITUR), Madeira, Portugal; and AQUAGEO Research Group, University of Campinas (UNICAMP), Brazil.",institutionString:"University of Johannesburg, South Africa and WSB University, Poland",institution:{name:"University of Johannesburg",institutionURL:null,country:{name:"South Africa"}}},editorThree:null}]},overviewPageOFChapters:{paginationCount:10,paginationItems:[{id:"81297",title:"Legumes Cropping and Nitrogen Fixation under Mediterranean Climate",doi:"10.5772/intechopen.104473",signatures:"Fernando Teixeira",slug:"legumes-cropping-and-nitrogen-fixation-under-mediterranean-climate",totalDownloads:2,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Food Systems Resilience",coverURL:"https://cdn.intechopen.com/books/images_new/10897.jpg",subseries:{id:"91",title:"Sustainable Economy and Fair Society"}}},{id:"81493",title:"Rust Disease Classification Using Deep Learning Based Algorithm: The Case of Wheat",doi:"10.5772/intechopen.104426",signatures:"Shivani Sood, Harjeet Singh and Suruchi Jindal",slug:"rust-disease-classification-using-deep-learning-based-algorithm-the-case-of-wheat",totalDownloads:39,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Food Systems Resilience",coverURL:"https://cdn.intechopen.com/books/images_new/10897.jpg",subseries:{id:"91",title:"Sustainable Economy and Fair Society"}}},{id:"81428",title:"Observatory of Sustainable Development in Postgraduate Study Programs in Baja California",doi:"10.5772/intechopen.104641",signatures:"Rodolfo Martinez-Gutierrez, Maria Marcela Solis-Quinteros, Maria Esther Ibarra-Estrada and Angel Ernesto Jimenez-Bernardino",slug:"observatory-of-sustainable-development-in-postgraduate-study-programs-in-baja-california",totalDownloads:9,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Globalization and Sustainability - Recent Advances, New Perspectives and Emerging Issues",coverURL:"https://cdn.intechopen.com/books/images_new/11476.jpg",subseries:{id:"91",title:"Sustainable Economy and Fair Society"}}},{id:"81235",title:"Global Food System Transformation for Resilience",doi:"10.5772/intechopen.102749",signatures:"Jasper Okoro Godwin Elechi, Ikechukwu U. Nwiyi and Cornelius Smah Adamu",slug:"global-food-system-transformation-for-resilience",totalDownloads:37,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Food Systems Resilience",coverURL:"https://cdn.intechopen.com/books/images_new/10897.jpg",subseries:{id:"91",title:"Sustainable Economy and Fair Society"}}}]},overviewPagePublishedBooks:{paginationCount:0,paginationItems:[]},openForSubmissionBooks:{paginationCount:1,paginationItems:[{id:"11601",title:"Econometrics - Recent Advances and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/11601.jpg",hash:"bc8ab49e2cf436c217a49ca8c12a22eb",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"May 13th 2022",isOpenForSubmission:!0,editors:[{id:"452331",title:"Dr.",name:"Brian",surname:"Sloboda",slug:"brian-sloboda",fullName:"Brian Sloboda"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},onlineFirstChapters:{paginationCount:1,paginationItems:[{id:"81831",title:"Deep Network Model and Regression Analysis using OLS Method for Predicting Lung Vital Capacity",doi:"10.5772/intechopen.104737",signatures:"Harun Sümbül",slug:"deep-network-model-and-regression-analysis-using-ols-method-for-predicting-lung-vital-capacity",totalDownloads:2,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Decision Science - Recent Advances and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/11604.jpg",subseries:{id:"86",title:"Business and Management"}}}]},subseriesFiltersForOFChapters:[{caption:"Business and Management",value:86,count:1,group:"subseries"}],publishedBooks:{paginationCount:1,paginationItems:[{type:"book",id:"11392",title:"Leadership in a Changing World",subtitle:"A Multidimensional Perspective",coverURL:"https://cdn.intechopen.com/books/images_new/11392.jpg",slug:"leadership-in-a-changing-world-a-multidimensional-perspective",publishedDate:"May 11th 2022",editedByType:"Edited by",bookSignature:"Muhammad Mohiuddin, Bilal Khalid, Md. Samim Al Azad and Slimane Ed-dafali",hash:"86a6d33cf601587e591064ce92effc02",volumeInSeries:1,fullTitle:"Leadership in a Changing World - A Multidimensional Perspective",editors:[{id:"418514",title:"Dr.",name:"Muhammad",middleName:null,surname:"Mohiuddin",slug:"muhammad-mohiuddin",fullName:"Muhammad Mohiuddin",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038UqSfQAK/Profile_Picture_2022-05-13T10:39:03.jpg",institutionString:null,institution:{name:"Université Laval",institutionURL:null,country:{name:"Canada"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Business and Management",value:86,count:1}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:1}],authors:{paginationCount:25,paginationItems:[{id:"429683",title:"Dr.",name:"Bilal",middleName:null,surname:"Khalid",slug:"bilal-khalid",fullName:"Bilal Khalid",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/429683/images/system/429683.png",biography:"Dr. Bilal Khalid received a Ph.D. in Industrial Business Administration from KMITL Business School, Bangkok, in 2021, and a master’s in International Business Management from Stamford International University, Bangkok, in 2017. Dr. Khalid\\'s research interests include leadership and negotiations, digital transformations, gamification, eLearning, blockchain, Big Data, and management of information technology. Dr. Bilal Khalid also serves as an academic editor at Education Research International and a reviewer for international journals.",institutionString:"KMITL Business School",institution:{name:"King Mongkut's Institute of Technology Ladkrabang",country:{name:"Thailand"}}},{id:"418514",title:"Dr.",name:"Muhammad",middleName:null,surname:"Mohiuddin",slug:"muhammad-mohiuddin",fullName:"Muhammad Mohiuddin",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038UqSfQAK/Profile_Picture_2022-05-13T10:39:03.jpg",biography:"Dr. Muhammad Mohiuddin is an Associate Professor of International Business at Laval University, Canada. He has taught at Thompson Rivers University, Canada; University of Paris-Est, France; Osnabruck University of Applied Science, Germany; and Shanghai Institute of Technology and Tianjin University of Technology, China. He has published research in Research Policy, Applied Economics, Review of Economic Philosophy, Strategic Change, International Journal of Logistics, Sustainability, Journal of Environmental Management, Journal of Global Information Management, Journal of Cleaner Production, M@N@GEMENT, and more. He is a member of CEDIMES Institut (France), Academy of International Business (AIB), Strategic Management Society (SMS), Academy of Management (AOM), Administrative Science Association of Canada (ASAC), and Canadian council of small business and entrepreneurship (CCSBE). He is currently the director of the Research Group on Contemporary Asia (GERAC) at Laval University. He is also co-managing editor of Transnational Corporations Review and a guest editor for Electronic Commerce Research and Journal of Internet Technology.",institutionString:null,institution:{name:"Université Laval",country:{name:"Canada"}}},{id:"189147",title:"Dr.",name:"Hailan",middleName:null,surname:"Salamun",slug:"hailan-salamun",fullName:"Hailan Salamun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/189147/images/19274_n.jpeg",biography:"Hailan Salamun, (Dr.) was born in Selangor, Malaysia and graduated from Tunku Ampuan Jamaah Religious High School at Shah Alam. Obtained a degree from the International Islamic University (UIA), Gombak in the field of Islamic Revealed Knowledge and Heritage. Next, I furthered my studies to the professional level to obtain a Diploma in Education at UIA. After serving for several years in school, I furthered my studies to the Master of Dakwah and Leadership at Universiti Kebangsaan Malaysia (UKM), Bangi. I graduated with a Doctor of Philosophy in Principalship Leadership from the University of Malaya (UM) in 2010. I am currently a senior lecturer in the Department of Nationalism and Civilization, Center for Basic and Continuing Education, Universiti Malaysia Terengganu. Prior to that, I had served in several educational institutions such as schools, the Institute of Teacher Education (IPG), and also the University of Malaya. I am also actively involved in paper presentation, writing and publishing. My research interests are focused on leadership, education, society and Islamic civilization. This area of research requires a detailed understanding of Islamic studies and research studies in leadership. Another research interest that I have explored recently is the politics of the Malay community and also the leadership of the mosque.",institutionString:null,institution:{name:"Universiti Malaysia Terengganu",country:{name:"Malaysia"}}},{id:"442081",title:"Dr.",name:"Audrey",middleName:null,surname:"Addy",slug:"audrey-addy",fullName:"Audrey Addy",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Kwame Nkrumah University of Science and Technology",country:{name:"Ghana"}}},{id:"437993",title:"Mr.",name:"Job",middleName:null,surname:"Jackson",slug:"job-jackson",fullName:"Job Jackson",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Management College of Southern Africa",country:{name:"South Africa"}}},{id:"428495",title:"Prof.",name:"Asyraf",middleName:null,surname:"Ab Rahman",slug:"asyraf-ab-rahman",fullName:"Asyraf Ab Rahman",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universiti Malaysia Terengganu",country:{name:"Malaysia"}}},{id:"429650",title:"Dr.",name:"Jacqueline",middleName:null,surname:"Kareem",slug:"jacqueline-kareem",fullName:"Jacqueline Kareem",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Christ University",country:{name:"India"}}},{id:"421041",title:"Dr.",name:"Sunil",middleName:null,surname:"Kumar Ramdas",slug:"sunil-kumar-ramdas",fullName:"Sunil Kumar Ramdas",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Jain University",country:{name:"India"}}},{id:"421833",title:"Mr.",name:"Eugene",middleName:null,surname:"Owusu-Acheampong",slug:"eugene-owusu-acheampong",fullName:"Eugene Owusu-Acheampong",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Ghana",country:{name:"Ghana"}}},{id:"239876",title:"Ph.D.",name:"Luciana",middleName:null,surname:"Mourão",slug:"luciana-mourao",fullName:"Luciana Mourão",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universidade Salgado de Oliveira",country:{name:"Brazil"}}},{id:"421735",title:"Dr.",name:"elizabeth",middleName:null,surname:"addy",slug:"elizabeth-addy",fullName:"elizabeth addy",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"442083",title:"Dr.",name:"James",middleName:null,surname:"Addy",slug:"james-addy",fullName:"James Addy",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"437991",title:"Prof.",name:"Muhammad",middleName:null,surname:"Hoque",slug:"muhammad-hoque",fullName:"Muhammad Hoque",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"421006",title:"Dr.",name:"Anna",middleName:null,surname:"Uster",slug:"anna-uster",fullName:"Anna Uster",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"470243",title:"Dr.",name:"Md Samim",middleName:null,surname:"Al Azad",slug:"md-samim-al-azad",fullName:"Md Samim Al Azad",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"470244",title:"Dr.",name:"Slimane",middleName:null,surname:"Ed-dafali",slug:"slimane-ed-dafali",fullName:"Slimane Ed-dafali",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"421011",title:"Dr.",name:"Afatakpa",middleName:null,surname:"Fortune",slug:"afatakpa-fortune",fullName:"Afatakpa Fortune",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"446057",title:"Mr.",name:"Okedare",middleName:null,surname:"David Olubukunmi",slug:"okedare-david-olubukunmi",fullName:"Okedare David Olubukunmi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"421778",title:"Dr.",name:"Fatimah",middleName:"Saeed",surname:"AlAhmari",slug:"fatimah-alahmari",fullName:"Fatimah AlAhmari",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"421024",title:"Prof.",name:"Harold Andrew",middleName:null,surname:"Patrick",slug:"harold-andrew-patrick",fullName:"Harold Andrew Patrick",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"421065",title:"Ms.",name:"Euzália",middleName:null,surname:"do Rosário Botelho Tomé",slug:"euzalia-do-rosario-botelho-tome",fullName:"Euzália do Rosário Botelho Tomé",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"421053",title:"Associate Prof.",name:"Ken",middleName:null,surname:"Kalala Ndalamba",slug:"ken-kalala-ndalamba",fullName:"Ken Kalala Ndalamba",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"421826",title:"Dr.",name:"Inusah",middleName:null,surname:"Salifu",slug:"inusah-salifu",fullName:"Inusah Salifu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"420823",title:"Prof.",name:"Gardênia da Silva",middleName:null,surname:"Abbad",slug:"gardenia-da-silva-abbad",fullName:"Gardênia da Silva Abbad",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"437613",title:"MSc.",name:"Juliana",middleName:null,surname:"Legentil",slug:"juliana-legentil",fullName:"Juliana Legentil",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null}]}},subseries:{item:{id:"20",type:"subseries",title:"Animal Nutrition",keywords:"Sustainable Animal Diets, Carbon Footprint, Meta Analyses",scope:"An essential part of animal production is nutrition. Animals need to receive a properly balanced diet. One of the new challenges we are now faced with is sustainable animal diets (STAND) that involve the 3 P’s (People, Planet, and Profitability). We must develop animal feed that does not compete with human food, use antibiotics, and explore new growth promoters options, such as plant extracts or compounds that promote feed efficiency (e.g., monensin, oils, enzymes, probiotics). These new feed options must also be environmentally friendly, reducing the Carbon footprint, CH4, N, and P emissions to the environment, with an adequate formulation of nutrients.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/20.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11416,editor:{id:"175967",title:"Dr.",name:"Manuel",middleName:null,surname:"Gonzalez Ronquillo",slug:"manuel-gonzalez-ronquillo",fullName:"Manuel Gonzalez Ronquillo",profilePictureURL:"https://mts.intechopen.com/storage/users/175967/images/system/175967.png",biography:"Dr. Manuel González Ronquillo obtained his doctorate degree from the University of Zaragoza, Spain, in 2001. He is a research professor at the Faculty of Veterinary Medicine and Animal Husbandry, Autonomous University of the State of Mexico. He is also a level-2 researcher. He received a Fulbright-Garcia Robles fellowship for a postdoctoral stay at the US Dairy Forage Research Center, Madison, Wisconsin, USA in 2008–2009. He received grants from Alianza del Pacifico for a stay at the University of Magallanes, Chile, in 2014, and from Consejo Nacional de Ciencia y Tecnología (CONACyT) to work in the Food and Agriculture Organization’s Animal Production and Health Division (AGA), Rome, Italy, in 2014–2015. He has collaborated with researchers from different countries and published ninety-eight journal articles. He teaches various degree courses in zootechnics, sheep production, and agricultural sciences and natural resources.\n\nDr. Ronquillo’s research focuses on the evaluation of sustainable animal diets (StAnD), using native resources of the region, decreasing carbon footprint, and applying meta-analysis and mathematical models for a better understanding of animal production.",institutionString:null,institution:{name:"Universidad Autónoma del Estado de México",institutionURL:null,country:{name:"Mexico"}}},editorTwo:null,editorThree:null,series:{id:"13",title:"Veterinary Medicine and Science",doi:"10.5772/intechopen.73681",issn:"2632-0517"},editorialBoard:[{id:"175762",title:"Dr.",name:"Alfredo J.",middleName:null,surname:"Escribano",slug:"alfredo-j.-escribano",fullName:"Alfredo J. Escribano",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRGnzQAG/Profile_Picture_1633076636544",institutionString:"Consultant and Independent Researcher in Industry Sector, Spain",institution:null},{id:"310962",title:"Dr.",name:"Amlan",middleName:"Kumar",surname:"Patra",slug:"amlan-patra",fullName:"Amlan Patra",profilePictureURL:"https://mts.intechopen.com/storage/users/310962/images/system/310962.jpg",institutionString:null,institution:{name:"West Bengal University of Animal and Fishery Sciences",institutionURL:null,country:{name:"India"}}},{id:"216995",title:"Prof.",name:"Figen",middleName:null,surname:"Kırkpınar",slug:"figen-kirkpinar",fullName:"Figen Kırkpınar",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRMzxQAG/Profile_Picture_1625722918145",institutionString:null,institution:{name:"Ege University",institutionURL:null,country:{name:"Turkey"}}}]},onlineFirstChapters:{paginationCount:25,paginationItems:[{id:"81796",title:"Apoptosis-Related Diseases and Peroxisomes",doi:"10.5772/intechopen.105052",signatures:"Meimei Wang, Yakun Liu, Ni Chen, Juan Wang and Ye Zhao",slug:"apoptosis-related-diseases-and-peroxisomes",totalDownloads:3,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"The Metabolic Role of Peroxisome in Health and Disease",coverURL:"https://cdn.intechopen.com/books/images_new/10837.jpg",subseries:{id:"11",title:"Cell Physiology"}}},{id:"81723",title:"Peroxisomal Modulation as Therapeutic Alternative for Tackling Multiple Cancers",doi:"10.5772/intechopen.104873",signatures:"Shazia Usmani, Shadma Wahab, Abdul Hafeez, Shabana Khatoon and Syed Misbahul Hasan",slug:"peroxisomal-modulation-as-therapeutic-alternative-for-tackling-multiple-cancers",totalDownloads:3,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"The Metabolic Role of Peroxisome in Health and Disease",coverURL:"https://cdn.intechopen.com/books/images_new/10837.jpg",subseries:{id:"11",title:"Cell Physiology"}}},{id:"81638",title:"Aging and Neuropsychiatric Disease: A General Overview of Prevalence and Trends",doi:"10.5772/intechopen.103102",signatures:"Jelena Milić",slug:"aging-and-neuropsychiatric-disease-a-general-overview-of-prevalence-and-trends",totalDownloads:14,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Senescence",coverURL:"https://cdn.intechopen.com/books/images_new/10935.jpg",subseries:{id:"11",title:"Cell Physiology"}}},{id:"81298",title:"Roles of Extracellular Vesicles in Cancer Metastasis",doi:"10.5772/intechopen.103798",signatures:"Eman Helmy Thabet",slug:"roles-of-extracellular-vesicles-in-cancer-metastasis",totalDownloads:20,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Extracellular Vesicles - Role in Diseases, Pathogenesis and Therapy",coverURL:"https://cdn.intechopen.com/books/images_new/10796.jpg",subseries:{id:"11",title:"Cell Physiology"}}},{id:"81290",title:"Musculoskeletal Abnormalities Caused by Cystic Fibrosis",doi:"10.5772/intechopen.104591",signatures:"Mark Lambrechts",slug:"musculoskeletal-abnormalities-caused-by-cystic-fibrosis",totalDownloads:13,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Advances in Skeletal Muscle Health and Disease",coverURL:"https://cdn.intechopen.com/books/images_new/11675.jpg",subseries:{id:"11",title:"Cell Physiology"}}},{id:"81226",title:"Computational Methods for the Study of Peroxisomes in Health and Disease",doi:"10.5772/intechopen.103178",signatures:"Naomi van Wijk and Michal Linial",slug:"computational-methods-for-the-study-of-peroxisomes-in-health-and-disease",totalDownloads:18,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"The Metabolic Role of Peroxisome in Health and Disease",coverURL:"https://cdn.intechopen.com/books/images_new/10837.jpg",subseries:{id:"11",title:"Cell Physiology"}}},{id:"80871",title:"Tumor-Derived Exosome and Immune Modulation",doi:"10.5772/intechopen.103718",signatures:"Deepak S. Chauhan, Priyanka Mudaliar, Soumya Basu, Jyotirmoi Aich and Manash K. Paul",slug:"tumor-derived-exosome-and-immune-modulation",totalDownloads:36,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Extracellular Vesicles - Role in Diseases, Pathogenesis and Therapy",coverURL:"https://cdn.intechopen.com/books/images_new/10796.jpg",subseries:{id:"11",title:"Cell Physiology"}}},{id:"80326",title:"Anti-Senescence Therapy",doi:"10.5772/intechopen.101585",signatures:"Raghad Alshadidi",slug:"anti-senescence-therapy",totalDownloads:91,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Senescence",coverURL:"https://cdn.intechopen.com/books/images_new/10935.jpg",subseries:{id:"11",title:"Cell Physiology"}}},{id:"79834",title:"Morphology and Formation Mechanisms of Cellular Vesicles Harvested from Blood",doi:"10.5772/intechopen.101639",signatures:"Veronika Kralj-Iglič, Gabriella Pocsfalvi and Aleš Iglič",slug:"morphology-and-formation-mechanisms-of-cellular-vesicles-harvested-from-blood",totalDownloads:50,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Extracellular Vesicles - Role in Diseases, Pathogenesis and Therapy",coverURL:"https://cdn.intechopen.com/books/images_new/10796.jpg",subseries:{id:"11",title:"Cell Physiology"}}},{id:"80195",title:"Diversity of Extracellular Vesicles (EV) in Plasma of Cancer Patients",doi:"10.5772/intechopen.101760",signatures:"Theresa L. Whiteside and Soldano Ferrone",slug:"diversity-of-extracellular-vesicles-ev-in-plasma-of-cancer-patients",totalDownloads:72,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Extracellular Vesicles - Role in Diseases, Pathogenesis and Therapy",coverURL:"https://cdn.intechopen.com/books/images_new/10796.jpg",subseries:{id:"11",title:"Cell Physiology"}}},{id:"79955",title:"The Role of Extracellular Vesicles in Immunomodulation and Pathogenesis of Leishmania and Other Protozoan Infections",doi:"10.5772/intechopen.101682",signatures:"Zeynep Islek, Batuhan Turhan Bozkurt, Mehmet Hikmet Ucisik and Fikrettin Sahin",slug:"the-role-of-extracellular-vesicles-in-immunomodulation-and-pathogenesis-of-em-leishmania-em-and-othe",totalDownloads:103,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Extracellular Vesicles - Role in Diseases, Pathogenesis and Therapy",coverURL:"https://cdn.intechopen.com/books/images_new/10796.jpg",subseries:{id:"11",title:"Cell Physiology"}}},{id:"80126",title:"Extracellular Vesicles as Biomarkers and Therapeutic Targets in Cancers",doi:"10.5772/intechopen.101783",signatures:"Prince Amoah Barnie, Justice Afrifa, Eric Ofori Gyamerah and Benjamin Amoani",slug:"extracellular-vesicles-as-biomarkers-and-therapeutic-targets-in-cancers",totalDownloads:86,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Extracellular Vesicles - Role in Diseases, Pathogenesis and Therapy",coverURL:"https://cdn.intechopen.com/books/images_new/10796.jpg",subseries:{id:"11",title:"Cell Physiology"}}},{id:"80108",title:"Exosomes and HIV-1 Association in AIDS-Defining Patients",doi:"10.5772/intechopen.101919",signatures:"Sushanta Kumar Barik, Sanghamitra Pati, Keshar Kunja Mohanty, Sashi Bhusan Mohapatra, Srikanta Jena and Srikanth Prasad Tripathy",slug:"exosomes-and-hiv-1-association-in-aids-defining-patients",totalDownloads:76,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Extracellular Vesicles - Role in Diseases, Pathogenesis and Therapy",coverURL:"https://cdn.intechopen.com/books/images_new/10796.jpg",subseries:{id:"11",title:"Cell Physiology"}}},{id:"79850",title:"Retracted: The Role of Extracellular Vesicles in the Progression of Tumors towards Metastasis",doi:"10.5772/intechopen.101635",signatures:"Bhaskar Basu and Subhajit Karmakar",slug:"retracted-the-role-of-extracellular-vesicles-in-the-progression-of-tumors-towards-metastasis",totalDownloads:154,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Extracellular Vesicles - Role in Diseases, Pathogenesis and Therapy",coverURL:"https://cdn.intechopen.com/books/images_new/10796.jpg",subseries:{id:"11",title:"Cell Physiology"}}},{id:"79828",title:"Cellular Senescence in Bone",doi:"10.5772/intechopen.101803",signatures:"Danielle Wang and Haitao Wang",slug:"cellular-senescence-in-bone",totalDownloads:88,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Senescence",coverURL:"https://cdn.intechopen.com/books/images_new/10935.jpg",subseries:{id:"11",title:"Cell Physiology"}}},{id:"79775",title:"Extracellular Vesicles as Intercellular Communication Vehicles in Regenerative Medicine",doi:"10.5772/intechopen.101530",signatures:"Gaspar Bogdan Severus, Ionescu Ruxandra Florentina, Enache Robert Mihai, Dobrică Elena Codruța, Crețoiu Sanda Maria, Crețoiu Dragoș and Voinea Silviu Cristian",slug:"extracellular-vesicles-as-intercellular-communication-vehicles-in-regenerative-medicine",totalDownloads:94,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Extracellular Vesicles - Role in Diseases, Pathogenesis and Therapy",coverURL:"https://cdn.intechopen.com/books/images_new/10796.jpg",subseries:{id:"11",title:"Cell Physiology"}}}]},publishedBooks:{paginationCount:2,paginationItems:[{type:"book",id:"9883",title:"Biosensors",subtitle:"Current and Novel Strategies for Biosensing",coverURL:"https://cdn.intechopen.com/books/images_new/9883.jpg",slug:"biosensors-current-and-novel-strategies-for-biosensing",publishedDate:"May 5th 2021",editedByType:"Edited by",bookSignature:"Luis Jesús Villarreal-Gómez and Ana Leticia Iglesias",hash:"028f3e5dbf9c32590183ac4b4f0a2825",volumeInSeries:11,fullTitle:"Biosensors - Current and Novel Strategies for Biosensing",editors:[{id:"126286",title:"Dr.",name:"Luis",middleName:"Jesús",surname:"Villarreal-Gómez",slug:"luis-villarreal-gomez",fullName:"Luis Villarreal-Gómez",profilePictureURL:"https://mts.intechopen.com/storage/users/126286/images/system/126286.jpg",institutionString:null,institution:{name:"Autonomous University of Baja California",institutionURL:null,country:{name:"Mexico"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"6843",title:"Biomechanics",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6843.jpg",slug:"biomechanics",publishedDate:"January 30th 2019",editedByType:"Edited by",bookSignature:"Hadi Mohammadi",hash:"85132976010be1d7f3dbd88662b785e5",volumeInSeries:4,fullTitle:"Biomechanics",editors:[{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",institutionURL:null,country:{name:"Canada"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},testimonialsList:[{id:"27",text:"The opportunity to work with a prestigious publisher allows for the possibility to collaborate with more research groups interested in animal nutrition, leading to the development of new feeding strategies and food valuation while being more sustainable with the environment, allowing more readers to learn about the subject.",author:{id:"175967",name:"Manuel",surname:"Gonzalez Ronquillo",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/175967/images/system/175967.png",slug:"manuel-gonzalez-ronquillo",institution:{id:"6221",name:"Universidad Autónoma del Estado de México",country:{id:null,name:"Mexico"}}}},{id:"18",text:"It was great publishing with IntechOpen, the process was straightforward and I had support all along.",author:{id:"71579",name:"Berend",surname:"Olivier",institutionString:"Utrecht University",profilePictureURL:"https://mts.intechopen.com/storage/users/71579/images/system/71579.png",slug:"berend-olivier",institution:{id:"253",name:"Utrecht University",country:{id:null,name:"Netherlands"}}}},{id:"8",text:"I work with IntechOpen for a number of reasons: their professionalism, their mission in support of Open Access publishing, and the quality of their peer-reviewed publications, but also because they believe in equality.",author:{id:"202192",name:"Catrin",surname:"Rutland",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",slug:"catrin-rutland",institution:{id:"134",name:"University of Nottingham",country:{id:null,name:"United Kingdom"}}}}]},submityourwork:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:98,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:287,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:10,numberOfPublishedChapters:103,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:10,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],subseriesList:[{id:"4",title:"Fungal Infectious Diseases",scope:"Fungi are ubiquitous and there are almost no non-pathogenic fungi. Fungal infectious illness prevalence and prognosis are determined by the exposure between fungi and host, host immunological state, fungal virulence, and early and accurate diagnosis and treatment. \r\nPatients with both congenital and acquired immunodeficiency are more likely to be infected with opportunistic mycosis. Fungal infectious disease outbreaks are common during the post- disaster rebuilding era, which is characterised by high population density, migration, and poor health and medical conditions.\r\nSystemic or local fungal infection is mainly associated with the fungi directly inhaled or inoculated in the environment during the disaster. The most common fungal infection pathways are human to human (anthropophilic), animal to human (zoophilic), and environment to human (soilophile). Diseases are common as a result of widespread exposure to pathogenic fungus dispersed into the environment. \r\nFungi that are both common and emerging are intertwined. In Southeast Asia, for example, Talaromyces marneffei is an important pathogenic thermally dimorphic fungus that causes systemic mycosis. Widespread fungal infections with complicated and variable clinical manifestations, such as Candida auris infection resistant to several antifungal medicines, Covid-19 associated with Trichoderma, and terbinafine resistant dermatophytosis in India, are among the most serious disorders. \r\nInappropriate local or systemic use of glucocorticoids, as well as their immunosuppressive effects, may lead to changes in fungal infection spectrum and clinical characteristics. Hematogenous candidiasis is a worrisome issue that affects people all over the world, particularly ICU patients. CARD9 deficiency and fungal infection have been major issues in recent years. Invasive aspergillosis is associated with a significant death rate. Special attention should be given to endemic fungal infections, identification of important clinical fungal infections advanced in yeasts, filamentous fungal infections, skin mycobiome and fungal genomes, and immunity to fungal infections.\r\nIn addition, endemic fungal diseases or uncommon fungal infections caused by Mucor irregularis, dermatophytosis, Malassezia, cryptococcosis, chromoblastomycosis, coccidiosis, blastomycosis, histoplasmosis, sporotrichosis, and other fungi, should be monitored. \r\nThis topic includes the research progress on the etiology and pathogenesis of fungal infections, new methods of isolation and identification, rapid detection, drug sensitivity testing, new antifungal drugs, schemes and case series reports. It will provide significant opportunities and support for scientists, clinical doctors, mycologists, antifungal drug researchers, public health practitioners, and epidemiologists from all over the world to share new research, ideas and solutions to promote the development and progress of medical mycology.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/4.jpg",keywords:"Emerging Fungal Pathogens, Invasive Infections, Epidemiology, Cell Membrane, Fungal Virulence, Diagnosis, Treatment"},{id:"5",title:"Parasitic Infectious Diseases",scope:"Parasitic diseases have evolved alongside their human hosts. In many cases, these diseases have adapted so well that they have developed efficient resilience methods in the human host and can live in the host for years. Others, particularly some blood parasites, can cause very acute diseases and are responsible for millions of deaths yearly. Many parasitic diseases are classified as neglected tropical diseases because they have received minimal funding over recent years and, in many cases, are under-reported despite the critical role they play in morbidity and mortality among human and animal hosts. The current topic, Parasitic Infectious Diseases, in the Infectious Diseases Series aims to publish studies on the systematics, epidemiology, molecular biology, genomics, pathogenesis, genetics, and clinical significance of parasitic diseases from blood borne to intestinal parasites as well as zoonotic parasites. We hope to cover all aspects of parasitic diseases to provide current and relevant research data on these very important diseases. In the current atmosphere of the Coronavirus pandemic, communities around the world, particularly those in different underdeveloped areas, are faced with the growing challenges of the high burden of parasitic diseases. At the same time, they are faced with the Covid-19 pandemic leading to what some authors have called potential syndemics that might worsen the outcome of such infections. Therefore, it is important to conduct studies that examine parasitic infections in the context of the coronavirus pandemic for the benefit of all communities to help foster more informed decisions for the betterment of human and animal health.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/5.jpg",keywords:"Blood Borne Parasites, Intestinal Parasites, Protozoa, Helminths, Arthropods, Water Born Parasites, Epidemiology, Molecular Biology, Systematics, Genomics, Proteomics, Ecology"},{id:"6",title:"Viral Infectious Diseases",scope:"The Viral Infectious Diseases Book Series aims to provide a comprehensive overview of recent research trends and discoveries in various viral infectious diseases emerging around the globe. The emergence of any viral disease is hard to anticipate, which often contributes to death. A viral disease can be defined as an infectious disease that has recently appeared within a population or exists in nature with the rapid expansion of incident or geographic range. This series will focus on various crucial factors related to emerging viral infectious diseases, including epidemiology, pathogenesis, host immune response, clinical manifestations, diagnosis, treatment, and clinical recommendations for managing viral infectious diseases, highlighting the recent issues with future directions for effective therapeutic strategies.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/6.jpg",keywords:"Novel Viruses, Virus Transmission, Virus Evolution, Molecular Virology, Control and Prevention, Virus-host Interaction"}],annualVolumeBook:{},thematicCollection:[],selectedSeries:null,selectedSubseries:null},seriesLanding:{item:null},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"chapter.detail",path:"/chapters/40609",hash:"",query:{},params:{id:"40609"},fullPath:"/chapters/40609",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()