Chemical composition of raw sugarcane bagasse (%w/w, dry basis).
\\n\\n
\\n"}]',published:!0,mainMedia:{caption:"Milestone",originalUrl:"/media/original/124"}},components:[{type:"htmlEditorComponent",content:'
Barely three months into the new year and we are happy to announce a monumental milestone reached - 150 million downloads.
\n\nThis achievement solidifies IntechOpen’s place as a pioneer in Open Access publishing and the home to some of the most relevant scientific research available through Open Access.
\n\nWe are so proud to have worked with so many bright minds throughout the years who have helped us spread knowledge through the power of Open Access and we look forward to continuing to support some of the greatest thinkers of our day.
\n\nThank you for making IntechOpen your place of learning, sharing, and discovery, and here’s to 150 million more!
\n\n\n\n\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"7132",leadTitle:null,fullTitle:"Complications of Pregnancy",title:"Complications of Pregnancy",subtitle:null,reviewType:"peer-reviewed",abstract:"Complications of pregnancy are health issues that are caused by pregnancy itself. These can happen during or after delivery (obstetric labor complications or puerperal disorders). Complications can be classified as mild, severe, immediate, or long-term health problems. Complications of pregnancy can cause maternal morbidity and mortality. The most common causes of maternal mortality are maternal bleeding, maternal sepsis, hypertensive diseases, obstructed labor, and pregnancy with the consequence of abortion, which includes miscarriage, ectopic pregnancy, and medical abortion.Heath problems can develop during pregnancy, which may be directly related to the pregnancy itself or nonobstetric disorders, such as pregnancy complicated by medical diseases. One of the main complications is obstetric abnormalities that increase the risk of morbidity or mortality for the pregnant woman and her fetus. High-risk pregnancy is an indicator of a maternal complication during pregnancy.",isbn:"978-1-83880-489-3",printIsbn:"978-1-83880-488-6",pdfIsbn:"978-1-83881-045-0",doi:"10.5772/intechopen.73930",price:119,priceEur:129,priceUsd:155,slug:"complications-of-pregnancy",numberOfPages:132,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"d2bdac8e99a71feab10bd0b9e1063bb9",bookSignature:"Hassan Abduljabbar",publishedDate:"June 12th 2019",coverURL:"https://cdn.intechopen.com/books/images_new/7132.jpg",numberOfDownloads:8444,numberOfWosCitations:1,numberOfCrossrefCitations:6,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:13,numberOfDimensionsCitationsByBook:1,hasAltmetrics:1,numberOfTotalCitations:20,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"May 14th 2018",dateEndSecondStepPublish:"August 28th 2018",dateEndThirdStepPublish:"October 27th 2018",dateEndFourthStepPublish:"January 15th 2019",dateEndFifthStepPublish:"March 16th 2019",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"68175",title:"Prof.",name:"Hassan",middleName:"S",surname:"Abduljabbar",slug:"hassan-abduljabbar",fullName:"Hassan Abduljabbar",profilePictureURL:"https://mts.intechopen.com/storage/users/68175/images/system/68175.png",biography:"Hassan S. Abduljabbar, MD, FRCSC, American Board Diplomate, is a professor at the College of Medicine, King Abdulaziz\nUniversity, Saudi Arabia. He is also the president of the Saudi Society of Obstetrics and Gynecology and the Federation of Arab\nGynecology Obstetric Societies (FAGOS). He is a referee for\nmany international scientific journals. He is also an examiner for\ngraduate degrees as well as for the Saudi and Arab board exams.\nDr. Abduljabbar has published more than fifty articles and edited three books.",institutionString:"Dr. Erfan & Bagedo General Hospital",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"3",totalChapterViews:"0",totalEditedBooks:"7",institution:{name:"King Abdulaziz University",institutionURL:null,country:{name:"Saudi Arabia"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"189",title:"Obstetrics and Gynecology",slug:"obstetrics-and-gynecology"}],chapters:[{id:"64142",title:"Placental Abnormalities",doi:"10.5772/intechopen.81579",slug:"placental-abnormalities",totalDownloads:1515,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"A detailed discussion of normal placental development and physiology is beyond the scope of this chapter and is discussed in other chapters. Instead, this chapter will focus on an overview of congenital placental abnormalities and the obstetrical complications that can arise. The goal of this chapter is to delineate the real-world implications of placental abnormalities and provide the reader with a basis for understanding the other chapters that will delve into microbiology, genomics, immunohistochemistry, and biochemistry of the placenta. The focus of this chapter will be on the developmental anomalies and this chapter will not discuss acquired anomalies (e.g., chorioamnionitis, amnion nodosum, metastatic tumors, and umbilical cord true knots). As the intention of this chapter is to focus on the etiopathogenesis of abnormal placentation, it is not intended to instruct the medical management of the described conditions, and therefore the discussions of management will be brief. The information provided is intended for general knowledge only and is not intended for use in diagnosing or treating a health problem or disease without consultation with a qualified healthcare provider. This chapter is not a substitute for professional medical advice, or treatment for specific medical conditions.",signatures:"Alexander L. Juusela",downloadPdfUrl:"/chapter/pdf-download/64142",previewPdfUrl:"/chapter/pdf-preview/64142",authors:[{id:"251181",title:"M.D.",name:"Alexander",surname:"Juusela",slug:"alexander-juusela",fullName:"Alexander Juusela"}],corrections:null},{id:"65996",title:"Miscarriage and Maternal Health",doi:"10.5772/intechopen.82117",slug:"miscarriage-and-maternal-health",totalDownloads:1090,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Miscarriage also known as spontaneous abortion is the termination of pregnancy before the age of fetal viability or expulsion of fetus or embryo weighing less than 500g. It occurs naturally without any human intervention and complicates about 15–20% pregnancies globally. The age of fetal viability varies from country to country depending on the level of technological development and fetal salvage rate. The age of fetal viability in Norway is 16 weeks, in Australia its 20 weeks, 24 weeks in the UK, 26 weeks in Spain and Italy while in Nigeria the age of fetal viability is 28 weeks of gestation. Causes of miscarriage include morphologic/genetic/chromosomal abnormalities, immunological and endocrine factors, structural uterine anomalies, cervical incompetence, maternal infections and toxins. It is classified into threatened miscarriage, inevitable miscarriage, incomplete miscarriage, septic miscarriage, missed miscarriage and complete miscarriage. Miscarriage has profound and tremendous psychologic and emotional effects on mothers before or during subsequent gestations. Every effort must be made to show understanding and empathy.",signatures:"John D. Ojule and Rosemary N. Ogu",downloadPdfUrl:"/chapter/pdf-download/65996",previewPdfUrl:"/chapter/pdf-preview/65996",authors:[{id:"213063",title:"Prof.",name:"Rosemary",surname:"Ogu",slug:"rosemary-ogu",fullName:"Rosemary Ogu"},{id:"262641",title:"Dr.",name:"John",surname:"Ojule",slug:"john-ojule",fullName:"John Ojule"}],corrections:null},{id:"65047",title:"Assessment of Fetal Gestational Age in the First Trimester in Normal and Abnormal Pregnancies: Which Sonographic Parameter to Use?",doi:"10.5772/intechopen.82746",slug:"assessment-of-fetal-gestational-age-in-the-first-trimester-in-normal-and-abnormal-pregnancies-which-",totalDownloads:947,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"To compare the correlation of various fetal ultrasound parameters to foot length, crown-rump length, and gestational age by date to determine the best estimate at 10–14 completed weeks’ gestation and to provide ratios of fetal parameters for assessment of fetal abnormalities in the first trimester. 35 routine obstetric scans were performed at 10–14 completed weeks’ gestation for fetal parameters and ratios. The fetal crown-rump length (CRL), biparietal diameter (BPD), head circumference (HC), abdominal circumference (AC), and femur length (FL) showed a linear correlation with the estimated gestational age by date (GA), crown-rump length (CRL), and foot length (FT) (p < 0.001), with the least correlation observed with GA and highest with FT. A combination of BPD, HC, AC, and FL correlated best with FT and then CRL and GA (R2 = 0.881, 0.795, and 0.685, respectively, p < 0.001). With the addition of CRL, R2 was 0.859. The ratio of FL/AC and FL/FT to FT, CRL, GA, BPD, and HC increases in an inverse relationship at 10–14 completed weeks’ gestation. The combination of BPD, HC, AC, and FL provides a better estimation of gestational age than (and hence may replace) CRL or GA at 10–14 weeks’ gestation.",signatures:"Hong Soo Wong",downloadPdfUrl:"/chapter/pdf-download/65047",previewPdfUrl:"/chapter/pdf-preview/65047",authors:[{id:"271674",title:"Dr.",name:"Hong Soo",surname:"Wong",slug:"hong-soo-wong",fullName:"Hong Soo Wong"}],corrections:null},{id:"64950",title:"Undernutrition during Pregnancy",doi:"10.5772/intechopen.82727",slug:"undernutrition-during-pregnancy",totalDownloads:1599,totalCrossrefCites:1,totalDimensionsCites:3,hasAltmetrics:0,abstract:"Experience in being pregnant is exciting but is very challenging. The term “undernutrition,” as used in this chapter, focuses more on inadequate intake of energy and nutrients to meet the desired outcome of a healthy mother and her baby. Evidence shows that women with undernutrition before and during pregnancy have increased risk of metabolic disorders (i.e., gestational diabetes mellitus) and are at increased risk of complications during labor and birth. To date, nutritional therapies promoting healthier pregnancies fall into the following two major categories: (1) management of gestational weight gain and (2) the prevention or treatment of nutrient deficiencies related to pregnancy. A literature search on PubMed, the Cochrane library, Google scholar, and Cumulative Index of Nursing and Allied Health Literature was conducted to identify the relevant nutritional therapies. As a result, this chapter will analyze and discuss gestational weight gain and its effect on the health of women and her baby. The chapter briefly proposes evidence-based nutritional therapy for gestational diabetes as well as gestational common nutrient imbalance, such as vitamin D, folic acid, and omega-3 docosahexaenoic acid deficiency. The recommendations, in this chapter, would be a partial answer for these problems in Asia.",signatures:"Hoang Anh Nguyen",downloadPdfUrl:"/chapter/pdf-download/64950",previewPdfUrl:"/chapter/pdf-preview/64950",authors:[{id:"277012",title:"M.Sc.",name:"Anh Hoang",surname:"Nguyen",slug:"anh-hoang-nguyen",fullName:"Anh Hoang Nguyen"}],corrections:null},{id:"65356",title:"Hydrops Fetalis",doi:"10.5772/intechopen.83443",slug:"hydrops-fetalis",totalDownloads:1202,totalCrossrefCites:0,totalDimensionsCites:2,hasAltmetrics:0,abstract:"The abnormal accumulation of fluid in two or more fetal space and in some cases is associated with placental edema and polyhydramnios. This can be seen in all trimesters. It is classified as immune and nonimmune fetal hydrops. Immune hydrops fetalis-rhesus alloimmunization and other blood group antibodies cause hemolytic disease of the newborn. Nonimmune hydrops fetalis can be largely divided as fetal, maternal, placental and idiopathic. Pathophysiology, investigations, treatment and counseling are outlined.",signatures:"Renuka Sekar",downloadPdfUrl:"/chapter/pdf-download/65356",previewPdfUrl:"/chapter/pdf-preview/65356",authors:[{id:"270919",title:"Dr.",name:"Renuka",surname:"Sekar",slug:"renuka-sekar",fullName:"Renuka Sekar"}],corrections:null},{id:"66384",title:"Maternal and Fetal Complications Due to Decreased Nitric Oxide Synthesis during Gestation",doi:"10.5772/intechopen.85383",slug:"maternal-and-fetal-complications-due-to-decreased-nitric-oxide-synthesis-during-gestation",totalDownloads:1004,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Nitric oxide (NO) is synthesized from L-arginine by the constitutive NO synthase in vascular endothelial cells and plays an important role in the regulation of blood pressure and coronary vasomotion. Normal pregnancy is associated with major adaptations in maternal cardiovascular function, which help the woman to accommodate the growing fetus. The vascular endothelium is stimulated during pregnancy to release increased amounts of NO, and the abnormality in the L-arginine NO pathway may play a role in the etiology of preeclampsia. The objective of this study is to discuss the importance of nitric oxide during gestation and the maternal and fetal complications associated with decreased NO synthesis during this period. Maternal arterial hypertension due to inhibition of nitric oxide synthesis during pregnancy impairs fetal development, mainly the reduction of the wall/lumen ratio of the cardiac and renal microvasculature as well as the reduction in the number of nephrons. These changes may contribute to the development of hypertension. Despite these findings, more studies are needed to understand the programming of fetal development, and the intrauterine environmental factors. influence this process.",signatures:"Sonia Jurado, Kaelly Saraiva, Cauane Marceliano, Vanessa Souza and Izabela Vieira",downloadPdfUrl:"/chapter/pdf-download/66384",previewPdfUrl:"/chapter/pdf-preview/66384",authors:[{id:"270974",title:"Ph.D.",name:"Sonia",surname:"Jurado",slug:"sonia-jurado",fullName:"Sonia Jurado"},{id:"272785",title:"Dr.",name:"Kaelly",surname:"Saraiva",slug:"kaelly-saraiva",fullName:"Kaelly Saraiva"},{id:"284172",title:"BSc.",name:"Cauane",surname:"Marceliano",slug:"cauane-marceliano",fullName:"Cauane Marceliano"},{id:"284174",title:"BSc.",name:"Vanessa",surname:"Souza",slug:"vanessa-souza",fullName:"Vanessa Souza"},{id:"284176",title:"BSc.",name:"Izabela",surname:"Vieira",slug:"izabela-vieira",fullName:"Izabela Vieira"}],corrections:null},{id:"66744",title:"Alloimmunization and Role of HLA in Pregnancy",doi:"10.5772/intechopen.84211",slug:"alloimmunization-and-role-of-hla-in-pregnancy",totalDownloads:1087,totalCrossrefCites:4,totalDimensionsCites:6,hasAltmetrics:1,abstract:"Alloimmunization also known as isoimmunization, during pregnancy is the production of IgG antibodies by the mother against the paternally inherited antigens (IPA) in the foetus/newborn. The alloimmunization during pregnancy leads to various alloimmune disorders, such as, haemolytic disease of the foetus and newborn (HDFN), neonatal alloimmune neutropenia (NAN) and foetal and neonatal alloimmune thrombocytopenia (FNAIT) due to the production of maternal alloantibodies against the red blood cell antigen, neutrophils and platelets cell antigens, respectively. Recent studies suggest that maternal anti-HLA class I alloantibodies may also be the cause of FNAIT in addition to antibodies against platelet antigens. On the contrary, studies have also suggested that HLA-C, a classical HLA class I molecule, and HLA-G, a nonclassical HLA molecule, play an important role in placentation and modulation of the maternal immune system during pregnancy, respectively, and thereby leading to acceptance of the semi allogeneic fetus. So far most of the studies have discussed alloimmunization in pregnancy relating to Rh antigen. Thus, in this chapter an attempt has been made to discuss alloimmunization in pregnancy caused because of maternal alloantibody against HLA antigen and its role in immune modulation during pregnancy.",signatures:"Meenakshi Singh, Jyoti Rajak, Shalaka Kadam and Sunil B. Rajadhyaksha",downloadPdfUrl:"/chapter/pdf-download/66744",previewPdfUrl:"/chapter/pdf-preview/66744",authors:[{id:"267032",title:"Dr.",name:"Meenakshi",surname:"Singh",slug:"meenakshi-singh",fullName:"Meenakshi Singh"},{id:"268554",title:"Ms.",name:"Jyoti",surname:"Rajak",slug:"jyoti-rajak",fullName:"Jyoti Rajak"},{id:"268555",title:"Ms.",name:"Shalaka",surname:"Kadam",slug:"shalaka-kadam",fullName:"Shalaka Kadam"},{id:"280190",title:"Dr.",name:"Sunil",surname:"Rajadhyaksha",slug:"sunil-rajadhyaksha",fullName:"Sunil Rajadhyaksha"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"10485",title:"Fibroids",subtitle:null,isOpenForSubmission:!1,hash:"64ad14b1aba83e47fb100fa63e21533e",slug:"fibroids",bookSignature:"Hassan Abduljabbar",coverURL:"https://cdn.intechopen.com/books/images_new/10485.jpg",editedByType:"Edited by",editors:[{id:"68175",title:"Prof.",name:"Hassan",surname:"Abduljabbar",slug:"hassan-abduljabbar",fullName:"Hassan Abduljabbar"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7969",title:"Leiomyoma",subtitle:null,isOpenForSubmission:!1,hash:"659a9fef0f90168b2184c86af85d3a42",slug:"leiomyoma",bookSignature:"Hassan Abduljabbar",coverURL:"https://cdn.intechopen.com/books/images_new/7969.jpg",editedByType:"Edited by",editors:[{id:"68175",title:"Prof.",name:"Hassan",surname:"Abduljabbar",slug:"hassan-abduljabbar",fullName:"Hassan Abduljabbar"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"814",title:"Steroids",subtitle:"Basic Science",isOpenForSubmission:!1,hash:"74304f5d822f8f45d4b48a0e00ebd375",slug:"steroids-basic-science",bookSignature:"Hassan Abduljabbar",coverURL:"https://cdn.intechopen.com/books/images_new/814.jpg",editedByType:"Edited by",editors:[{id:"68175",title:"Prof.",name:"Hassan",surname:"Abduljabbar",slug:"hassan-abduljabbar",fullName:"Hassan Abduljabbar"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2013",title:"Steroids",subtitle:"Clinical Aspect",isOpenForSubmission:!1,hash:"31dfd32a77f71bc348d7922af48b8e62",slug:"steroids-clinical-aspect",bookSignature:"Hassan Abduljabbar",coverURL:"https://cdn.intechopen.com/books/images_new/2013.jpg",editedByType:"Edited by",editors:[{id:"68175",title:"Prof.",name:"Hassan",surname:"Abduljabbar",slug:"hassan-abduljabbar",fullName:"Hassan Abduljabbar"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10721",title:"Preeclampsia",subtitle:null,isOpenForSubmission:!1,hash:"eb38592b7a656d02dd6b28c34e43de32",slug:"preeclampsia",bookSignature:"Hassan Abduljabbar",coverURL:"https://cdn.intechopen.com/books/images_new/10721.jpg",editedByType:"Edited by",editors:[{id:"68175",title:"Prof.",name:"Hassan",surname:"Abduljabbar",slug:"hassan-abduljabbar",fullName:"Hassan Abduljabbar"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5937",title:"Obstetrics",subtitle:null,isOpenForSubmission:!1,hash:"092197b1191815505a23e7dd1c9edde6",slug:"obstetrics",bookSignature:"Hassan Salah Abduljabbar",coverURL:"https://cdn.intechopen.com/books/images_new/5937.jpg",editedByType:"Edited by",editors:[{id:"68175",title:"Prof.",name:"Hassan",surname:"Abduljabbar",slug:"hassan-abduljabbar",fullName:"Hassan Abduljabbar"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6191",title:"Selected Topics in Breastfeeding",subtitle:null,isOpenForSubmission:!1,hash:"3334b831761ffa52e78de6fc681e33b3",slug:"selected-topics-in-breastfeeding",bookSignature:"R. Mauricio Barría P.",coverURL:"https://cdn.intechopen.com/books/images_new/6191.jpg",editedByType:"Edited by",editors:[{id:"88861",title:"Dr.",name:"R. Mauricio",surname:"Barría",slug:"r.-mauricio-barria",fullName:"R. Mauricio Barría"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10460",title:"Current Topics in Caesarean Section",subtitle:null,isOpenForSubmission:!1,hash:"e59550fca39fd09ff4addfe39ca822a0",slug:"current-topics-in-caesarean-section",bookSignature:"Panagiotis Tsikouras, Nikolaos Nikolettos, Werner Rath and Georg Friedrich Von Tempelhoff",coverURL:"https://cdn.intechopen.com/books/images_new/10460.jpg",editedByType:"Edited by",editors:[{id:"48837",title:"Prof.",name:"Panagiotis",surname:"Tsikouras",slug:"panagiotis-tsikouras",fullName:"Panagiotis Tsikouras"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8557",title:"Empowering Midwives and Obstetric Nurses",subtitle:null,isOpenForSubmission:!1,hash:"c6d90f0978fbce94e13061740cb1d4bc",slug:"empowering-midwives-and-obstetric-nurses",bookSignature:"Amita Ray",coverURL:"https://cdn.intechopen.com/books/images_new/8557.jpg",editedByType:"Edited by",editors:[{id:"251100",title:"Prof.",name:"Amita",surname:"Ray",slug:"amita-ray",fullName:"Amita Ray"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10929",title:"The Gynecological Papyrus Kahun",subtitle:null,isOpenForSubmission:!1,hash:"b8818312089bdfb0423707a231e104d8",slug:"the-gynecological-papyrus-kahun",bookSignature:"Helena Trindade Lopes and Ronaldo G. 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In 2010, he received a Ph.D. in Egyptology from the University of Basel, Switzerland.\nFrom 2012 to 2017, Dr. Pereira was a post-doctoral fellow at CHAM/FCSH – Universidade Nova de Lisboa.\nIn 2018, he became an Onassis Fellow, hosted by the Department of Mediterranean Studies, University of the Aegean, Greece. \nIn 2019, he became an auxiliary researcher at CHAM/FCSH – Universidade Nova de Lisboa. 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Applying today’s computing and control equipment and techniques is one of the most cost-effective and significant opportunities for larger energy users to reduce their energy costs and improve profits. An Energy Management Information System (EMIS) is an important element of a comprehensive energy management program. It provides relevant information to key individuals and departments that enable them to improve energy performance. Today it is normal for companies, particularly in process sectors, to collect huge amounts of real-time data from automated control systems, including Programmable Logic Controllers (PLCs), Supervisory Control and Data Acquisition (SCADA), etc. The captured data is shared and analysed in an orderly and precise way that identifies problem areas and provides solutions, this mass of data is merely information overload. Advances in information technology (IT), defined here as the use of computers to collect, analyse, control and distribute data, have developed rapidly. It is now common for managers and operators to have access to powerful computers and software. Today there are a number of techniques to analyse the factors that affect efficiency, and models are automatically generated based on “what if” scenarios in order to improve decisions to be taken.
The paper shows a very advanced technology for handling automatically more than 200 digital and analogue (i/p and o/p) parameters via intelligent monitoring and controlling system.
However, load management is the process of scheduling the loads to reduce the electric energy consumption and or the maximum demand. It is basically optimizing the processes/loads to improve the system load factor. Load-management procedures involve changes to equipment and/or consumption patterns on the customer side. There are many methods of load management which can be followed by an industry or a utility, such as load shedding and restoring, load shifting, installing energy-efficient processes and equipment, energy storage devices, co-generation, non-conventional sources of energy, and reactive power control [1]-[3]. Meeting the peak demand is one of the major problems now facing the electric utilities. With the existing generating capacity being unmanageable, authorities are forced to implement load shedding in various sectors during most of the seasons. Load shifting will be a better option for most industries. Load shifting basically means scheduling the load in such a way that loads are diverted from peak period to off-peak periods, thereby shaving the peak and filling the valley of the load curve, so improving the load factor[4]-[6].
To encourage load shifting in industries, and thereby to reduce peak demand automatically, a new technology such as introduced here will be extended.
Also, power quality is of major concern to all types of industries, especially those operating with critical machinery and equipments. Poor quality of power leads to major problems like break-downs, production interruptions, excess energy consumption etc. Modern industries require automation of their operation enabling them to produce quality products and also for mass production. The conventional systems are being replaced by modern Power Electronic systems, bringing a variety of advantages to the users. Classic examples are DC & AC Drives, UPS, soft starters, etc. Power Quality Alarming and Analysis provides a comprehensive view into a facility\'s electrical distribution system. Power Quality can be monitored at the electrical mains or at any critical feeder branch in the distribution system such as described here. Devices in this category typically provide all of the parameters found in basic devices, plus advanced analysis capabilities [7]-[8]. These advanced analysis capabilities include using waveform capture to collect and view waveform shape and magnitude, providing harmonic analysis graphs, collection and storage of events and data, and recording single or multiple cycle waveforms based on triggers such as overvoltage or transients. With the ever-increasing use of sophisticated controls and equipment in industrial, commercial, and governmental facilities, the continuity, reliability, and quality of electrical service has become extremely crucial to many power users. Electrical systems are subject to a wide variety of power quality problems which can interrupt production processes, affect sensitive equipment, and cause downtime, scrap, and capacity losses. Momentary voltage fluctuations can disastrously impact production [7]-[8].
The proposed modified intelligent monitoring and controlling system will introduce monitoring, alarming, controlling, and power quality mitigation based on data collected and analyzed from the system. The original system can afford the following features:
Complete information about the plant (circuit breakers status, source of feeding, and level of the consumed power).
Information about the operating values of the voltage, operating values of the transformers, operating values of the medium voltage, load feeders, operating values of the generators. These values will assist in getting any action to return the plant to its normal operation by minimum costs.
Protective information such as the insulation of cables, temperatures of the generators. These parameters are used as a back up for the main protection.
Information about the quality of the system (harmonics, current, voltages, power factors, flickers, etc.). These values will be very essential in case of future correction.
Recorded information such case voltage spikes, reducing the voltage on the medium or current interruption.
The hardware configuration of the original intelligent monitoring and controlling system is divided into two levels. The first level includes two workstations -1 and -2 with two different software programs are used for data handling and monitoring purpose. The second level includes the PLC for data collected that constituted from 10 digital meters and some smart sensors to cover many points in the system. Some digital meters are fed directly to the workstation-2 using different software for data handling. All other parameters such as breaker status, temperature, controllers, and cable insulators are fed through the PLC. Fig. 1 shows the overall structure of original intelligent monitoring and controlling system achieved at the Eastern Company in Egypt. The intelligent monitoring and controlling system uses the most recent technology of Profibus in data transferring. Workstaton-1 used the Wincc flexible software program for data handling received from the MV, Transformers and Generators. Workstation-2 used the Sicaro Q manger software program for data handling from the loads. Both workstations are linked through Ethernet network. One programmable logic controller S7-300 associated with 10 power meters for monitoring the MV, Transformers and Generators, Insulation relays, Temperature transducers for generators, and Circuit Breakers auxiliary points for all loads have been applied to workstation 1 through Profibus network-1. Workstation-2 associated with 12 power quality meters for monitoring all loads (Compressors, Pumps, Motors, Processes, etc.) via Profibus network-2. All system parameters are communicated using the Profibus technology. The output system is limited by given alarming and recommendation to the operator without doing any automatic actions for the system. The system components used in the system are produced from Siemens and can be described as:
PROFIBUS is the powerful, open and rugged bus system for process and field communication in cell networks with few stations and for data communication. Automation devices such as PLCs, PCs, HMI devices, sensors or actuators can communicate via this bus system. PROFIBUS is part of totally integrated automation, the uniform, integrated product and system range from Siemens for efficient automation of the entire production process for all sectors of industry. PROFIBUS can be used, for example, for the following applications: Factory automation, Process automation and Building automation. Different PROFIBUS versions are available for the various fields of application:
Process or field communication (PROFIBUS DP) (for fast, cyclic data exchange with field devices). PROFIBUS PA (for intrinsic safety applications in process automation)
Data communication (PROFIBUS FMS) (for data communication between programmable controllers and field devices).
Power Quality devices are installed at various measuring points in order to record a series of measurements of the required values for an analysis of the network quality. The devise can be installed on the load. In addition to all relevant measured variables, the meter can also record system disturbances, always when an upward or downward limit value violation has occurred. The recorded values can be called up and evaluated using a PC. Power Quality is available in 3 device versions with the following communication interfaces: RS232, RS485, and PROFlBUS-DP. Furthermore the device version Power Quality with PROFIBUS-DP interface opens up another area of application. Together with programmable control systems (PLCs), it can be used as a “sensor” for electrical measured variables. In the system achieved, the PROFIBUS-DP technology is used.
The Power Quality PAR parameterization software is executable under the Windows 2000/XP operating systems. The software allows you to define the device address, so that each device is uniquely identified and to configure the power quality for the communication protocol to be used (PROFIBUS DP) in order to prepare it for the measurement task. Fig. 2 shows the display of the currently transmitted measured values.
Power Meter is a power meter for panel mounting, with big graphic display and background illumination. The major application area is power monitoring and recording at MV and LV level. The major information types are measured values, alarms and status information. Power monitoring systems with Power Meter, a permanently installed system, enables continuous logging of energy-related data and provides information on operational characteristics of electrical systems. Power Meter helps identify sources of energy consumption and time of peak consumption. This knowledge allows you to allocate and reduce energy costs. Measured values include r.m.s values of voltages (phase-to-phase and/or phase-to-ground), currents, active, reactive and apparent power and energy, frequency, power factor, phase angle per phase, symmetry factor, harmonics of currents and voltages, total harmonic distortion. Ten maters are installed on the system and arranged on the incoming feeders, transformers and also on the generators. PROFIBUS-DP and Power Meter are connected in a master-slave operation mode. The communication parameters are loaded to the master station using the GSD file. The Power Meter supports data transmission rates from 9.6 kbit/s to 12 Mbit/s. The Measured values can be: Voltage, Current, Active power, Reactive power, Apparent power, Power factor, Active power factor, Phase angle, Frequency, Active energy demand, Active energy supply, Active energy total, Active energy total, Reactive energy, inductive, Reactive energy, capacitive, Reactive energy total, Apparent energy, Unbalance voltage, Unbalance current, THD voltage, THD current, Harmonic voltage, and Harmonic current.
SIMATIC S7-300 PLC: S7-300 programmable controller is made up of the following components:
Power supply (PS)
Signal modules (SM)
Function modules (FM)
Communication processor (CP).
Several S7-300s can communicate together and with other SIMATIC S7 PLCs via PROFIBUS bus cables. Fig. 3 shows the components of the PLC. The Runtime application of the WinCC basic software offers all essential functions of a powerful SCADA-System. Using WinCC User Administrator, One can assign and control users access rights for configuration and runtime.
The application functions of the data collection and monitoring are all performed via two workstations, PLC and two different software programmes. The program can include data exchange communication protocol between the communication system and PLC, through digital power meters, breakers’ status (On/Off), power quality monitoring, threshold for alarming. Figs. 4 and 5 show part of the system operation for monitoring feeder-2 and transformer-2 parameters for the system installed at Eastern Company in Egypt. Fig. 6 shows one of the event messages produced from the system. Fig. 7 shows the block diagram that demonstrates the various function components of IMCS. All of these components are programmed as functions of the system. Some of the system functionality can be described as;
Sensors and power meters communicate measurements and status information from the plant to the monitoring modules of the IMCS.
IMCS offers a wide range of options for monitoring the plant. Information can be monitored locally and centrally. Access to the IMCS is protected and the users must login to gain access to functionality. Information received from the plant can be monitored in different forms from data or trends mode. The monitoring includes; Alarms, Trends, Recommendations Status, Configuration utilities, Event messages, etc.
The control of the system is limited while the system is based on monitoring purposes and given recommendation messages for the operator.
The IMCS has the feature of data logging for some selected parameters such as (switching procedure during week; temperature, breaker status, transients, etc.) for further analysis.
The main feature of the IMCS is producing the alarms, recommendation and event reporting functionality. The alarms, recommendation and event reporting are based on customers basis.
Predictive maintenance is an essential part of the IMCS. The system gives all information about the power quality of the plant and cable insulation. This can be achieved through reports and alarms message produced from the system.
The overall structure of the original intelligent monitoring and controlling system.
The display of the currently transmitted measured values of Quality Meter used in the system.
The main components of the PLC.
Part of the monitored data on fedder-2 at Eastern Company.
Part of the monitored data on Transfwer-2 at Eastern Company.
One of the output event messages produced from the system at Eastern Company.
Block diagram of the IMCS components installed at Eastern Company.
The original system is used mainly for monitoring purposes with some recommendation messages produced from it. The paper introduces an extension for the system for producing many digital and analogue output signals from the PLC to control loads based on load management programs and power quality mitigation procedure. The proposed modified system can accept load management schemes load shedding during peak period, cycling on/off load control, and direct load control. The modified IMCS associated with load management and power quality schemes gives the customer the possibility of load reduction or control during the peak periods of the day, moreover, gives more information about the power quality of the system.
The modified IMCS with Load management can include:
Load shedding during peak
Cycling on/off load control,
Direct load control.
The modified IMCS with power quality monitoring can include:
Monitoring overvoltage or transients
Monitoring harmonic graphs for feeders and loads
Monitoring power failure
Monitoring High frequency noise
Monitoring Spikes
Monitoring ground faults and deterioration insulation in cables
The IMCS can also monitor all the breakers status and temperatures of the stand-by generators. The following subsections explain some function components embedded in the modified IMCS
The new generation of the power monitoring device provides accurate knowledge of the systems characteristics with maximum, minimum and average values for voltage, current, power values, frequency, power factor, symmetry and THD. The SENTRON PAC4200 detects the values for active, reactive and apparent energy – both for high and low tariff. It measures ratings and power values via the four quadrants, i.e. power import and export are measured separately. The SENTRON PAC4200 also facilitates the detection of a measuring period’s average values for active and reactive power. These values can be further processed into load curves in a power management system. Typically, 15-minute intervals are used for this purpose. PAC4200 also detects uneven harmonics from the 3rd to the 31st for voltage and current, the distortion current strength (Id), the phase angle and the asymmetry for voltage and current with reference to the amplitude and phase. For further processing of the measured data, the devices can be very easily integrated in superior automation and power management systems in the proposed system the meters are interfaced with SIMATIC PCS 7 powerrate and SIMATIC WinCC powerrate software packages. The Wincc powerrate software packages can handle very complicated schemes for load management.
The purpose of the control module in the modified IMCS is to provide the control of the necessary parameters for each point in the plant. It provides the functionality required to control the load in case of peak period or in case of exceeding the threshold boundary. It offers control functionality, e.g. load shedding, on/off load control, direct load control, power quality control. It also provides the functionality required to control devices such as pumps, motors, compressors, on/off breakers, interlocking, power quality mitigation. Operation can be configured to be automatic. The modified system offers the facility for adjusting control parameters (e.g., set points, output quantity, tolerances, time delay) in order to achieve the desired condition for each program. Fig. 8 shows the new added function blocks for the modified intelligent monitoring and controlling system. The figure shows three main components; workstation-2 with control scheme, Control output module, new generation of the power quality meters compatible with Wincc powerrate software program. As given in Fig. 9, the proposed modified system uses one additional PLC interfaced with the new power quality meters located on the loads. The data is shared through Profibus network-2. Workstation-2 uses Wincc powerrate software program for programming and controlling purposes. Workstation-2 manipulates different load management programs through collected data received from the PLC. Many controlled output signals are produce from the PLC o/p modules. The proposed modified system avoids many of original system limitations by replacing the power quality meters interfaced directly with workstation-2. The proposed modified IMCS can manipulate the following programs;
Block diagram of the modified IMCS function components.
The overall structure of the proposed modified intelligent monitoring and controlling system.
A company\'s electric bill, in most countries, consists of two major components: demand charge and energy consumption charge. Demand charges are reset monthly and are based on the highest rate at which electricity is consumed during periods that are peak utility service hours. Demand charges are measured in kilowatts and, depending on the utility service provider, the highest consumption rate is measured in 15- or 30-minute intervals during peak hours or contracted value. Demand charges form a significant portion of a company\'s monthly electric bill. Peak load management strategies that lower a facility\'s demand during times when the peak demand is measured can result in significant facility cost savings, especially for commercial, industrial and governmental sectors. Fig. 10 shows the procedure of the load management that can be achieved automatically in the proposed modified IMCS. The scheme of load management can be built and programmed according to previous scenario using energy auditing. In such a case the customer can avoid any penalty from the utility and can save money as well. The procedure of the control can be run through workstation-2 and the readings of the loads received from PLC with power quality meters. The program can be run under Wincc powerrate software program. Firstly, the system will check the required load capacity to be shaved during peak value and then select the minimum diesel power generated that coves the required loads. The system will produce output signal through the PLC output module to the suitable generator/generators. In case of the load reduction the system disconnects the generator/-s sequentially according to the required load and get back the loads to the normal operation on their feeders.
The load management control for avoiding the peak period.
Flow generating equipment like fans, pumps and compressors are often used without speed control. In stead, flow is traditionally controlled by throttling or using a valve or damper. When flow is controlled without regulating the motor speed, it runs continuously full speed. Because HVAC systems rarely required maximum flow, a system operating without speed control wastes significant energy over most of its operating time. Using VFD to control the motor speed can save up to 70% of the energy (Central line of Honeywell). HVAC system consumes a large percentage of the total energy utilized by the organization. The original IMCS can not do that. The extended system can include VFD interfaced with the PLC and can run according to the given parameters and atmospheric boundary conditions in the side control module. The devices such as chillers, motors (pumps and fans) and AHU are controlled using VFD through the proposed modified IMCS.
The demands to the power reliability and the power quality become stricter due to the popular application of variable-frequency and variable-speed drives, robots, automated production lines, accurate digital-control machines, programmable logic controllers, information manage systems in computers and so on. These devices and computer systems are very sensitive to the power-supply ripple and various disturbances. Any power quality problems may result in the reduction of product quality or confusion of management order which means great economic loss. Power Quality can be measured with power quality meters and analyzed with software in the control module. Power Quality events usually are infrequent, making them hard to detect and store without specialized equipment. Over a certain period, there may only be a few Power Quality events. The system is able to collect and analyze events on the basis for identifying the Power Quality problem. Analyzed data is the starting point for improvement. Data identifies potential sources of problems based on the timing of the events. This information can show the cause of the problem. Once the source is identified, improvement begins based on corrective actions. Corrective actions may include: changing motor starting procedures, replacing faulty switches or relays, filtering harmonic producing loads, or changing switching schedules for power factor correcting capacitors, changing control of the power filter. Once the corrections are in place, further monitoring will verify that the corrective action worked. The applied system such as IMCS can line with this specifications for power quality mitigation.
The application of good plant quality and demand control concepts requires an understanding of utility rates, auditing, and metering in addition to a basic knowledge of the process and load being controlled or shed. This process is professionally achieved in Eastern Company with 10MW capacity and 11kV/380V plant before installing the original intelligent monitoring and controlling system. The paper introduced an overview explanation for the original IMCS achieved at the Eastern Company. The paper also proposed modified intelligent monitoring and controlling system that has the feature of high speed data manipulation through the technology of Profibus and new generation of digital meters. The proposed modified system has the function of demand monitoring/load shedding scheme that operated in automatic mode. Also, Power Quality can be measured with power quality meters and analyzed with software in the control module. Data identifies potential sources of problems based on the timing of the events.
The feature of the energy consumption and power quality mitigation are significantly enhancing the power system operation. The proposed system has the features of
Accurate load management during peak periods designed based on the plant requirements,
Real time monitoring of the plant performance,
Intelligent alarming capabilities for early power quality problems
Predictive maintenance planning for cables and standby generators
Energy management
Power system efficiency
Save money by avoiding any penalty from the utility
Keep the voltage tolerance with the allowed limits
Continuous monitoring for the power quality
Load control and management with proper methodology
Keep the consumption with the contracted limit
Recoding information that can assist for any future development for the electrical network
Catching any transient vents happened in the system
Mitigation the plant through continuous monitoring of the power quality
Fault diagnosis and alarming
Identify and fix the causes of power disturbances to avoid recurrences
Improved system efficiency
The authors are going to implement the modified components of the IMCS.
Biomass resources are readily available globally as residual wastes derived from agricultural and industrial sources. Crop residues such as corn straw, wheat straw, and rice straw are classified as important and relatively abundant renewable biomass resources [1, 2]. With regards to the abundance of biomass resources, China still leads as one of the largest agricultural-based economies in the world, producing approximately about 216 million metric tons of corn straw per annum. For the aforementioned, more than half of that reported from China remain unutilized [3]. Lignocellulose arises from corn straw containing non-edible plant material, composed largely of cellulose, hemicellulose, and lignin. These three components comprise covalent cross-linkages between the polysaccharides (cellulose and hemicellulose) and lignin, making biomass a composite material [4]. The sources and compositions of lignocellulose play a very important role in predicting its potential as value added-products. The hemicellulose is present as the matrix that surrounds the cellulose skeleton, while lignin is present as an encrusting material and serves as a protective layer. However, biomass pretreatment is an essential tool for cellulose conversion processes as it changes the structure of cellulosic biomass to make cellulose more available to the enzymes that convert the carbohydrate polymers into fermentable sugars [5]. Other studies have reported that pretreatment of lignocellulosic biomass (LB) aids to overcome recalcitrance through the combination of chemical and structural changes to the lignin and carbohydrates. Some of the different methods of pretreatment include physical; namely, mechanical pretreatment, physicochemical; namely, steam explosion, chemical; namely, alkali and acidic pretreatment, and biological; namely, manure addition or mixed microorganisms [6, 7]. Nonetheless, these traditional methods of pretreatment are cost-intensive, as additional chemicals or energy are required [8]. Also, useful information for policymakers and researchers on lignin biorefinery is presented in this chapter.
LB is a composite, based on intertwined biopolymers on a dry basis, consisting of 35–45% cellulose, 25–30% hemicellulose, and 25–30% lignin [9]. These are classified into four major proportions based on their source, namely, woody biomass, agricultural residues (for example, rice/wheat/barley straws, corn stover, sugarcane bagasse), energy crops (switchgrass,
Components (%) | References | ||
---|---|---|---|
Cellulose | Hemicellulose | Lignin | |
47.0 | 27.0 | 23.0 | [14] |
38.8 | 26.0 | 32.4 | [15] |
45.5 | 27.0 | 21.1 | [16] |
38.4 | 23.2 | 25.0 | [17] |
45.0 | 25.8 | 19.1 | [18] |
39.5 | 25.6 | 30.4 | [19] |
43.6 | 17.2 | 22.0 | [20] |
Chemical composition of raw sugarcane bagasse (%w/w, dry basis).
Cellulose is a linear polymer of β-D-glucopyranose units linked to each other by 1,4-glycosidic bonds. The linear cellulose chain has a very strong tendency to form intra and inter-molecular hydrogen bonds, which promotes the collection of parallel chains into basic microfibrils. Most wood species contain 40–45% cellulose based on oven-dry (OD) wood. Compression wood of softwoods contains less crystalline cellulose than non-compression wood [13]. The chemical structure of cellulose is shown in Figure 1.
Chemical structure of cellulose [
This is the second most abundant structural component of a typical plant cell wall after cellulose [21]. Cellulose microfibrils are thus linked together in a hydrogen bond with hemicellulose forming cellulose microfibrils (fibers). Hemicellulose has a random, amorphous structure and can be easily hydrolyzed by dilute acid or alkaline of various 5 and 6 carbon sugars, including arabion-xylans glucomannans, and galactans. Xylan is a family of polysaccharides most common to hemicellulose [22]. The schematic diagram is shown in Figure 2.
Chemical structure of hemicellulose [
Lignin is the third most abundant structural component in nature of a typical plant cell wall after cellulose and hemicellulose [14]. This amorphous heteropolymer consists of three different phenylpropane units, namely, p-coumaryl, coniferyl and sinapyl alcohol joined by different linkages (presented in Figure 3). Lignin was first discovered in 1813 by a Swiss botanist, A. P de Candolle who described it as fibrous, tasteless and insoluble in water and alcohol, but soluble in a weakly basic solution, thus, making it difficult for biodegradation [15]. It is a class of complex organic polymer forming structural materials for supporting tissues of vascular plants and offers impermeability and resistance to microbial attacks [16]. It strengthens stems and vascular tissue, allowing upward growth and permits water and minerals to be conducted through the xylem under negative pressure without collapse of the tissue. In addition to mechanical support, lignin contributes to protective functions in plants by, for example, increasing resistance to biodegradation and environmental stresses, such as changes in humidity and water balance.
Chemical structure of the main monolignols of lignin.
Application of biorefining to bagasse requires lignocellulose fractionation into cellulose, hemicelluloses and lignin [17]. This step involves pretreatment where a considerable part of hemicelluloses is solubilized. In this regard, the cellulose portion is activated initially towards enzymatic hydrolysis and subsequently, for ethanol/biogas production. The use of pretreatment in the conversion of LB for bioenergy production is to enhance the release of cellulose and disrupt lignin and hemicellulose [13]. The sole aim is to remove lignin and hemicellulose, thereby enhancing the cellulose crystallinity and porosity for easier accessibility of microbes to breakdown lignocellulosic feedstock [18]. Various feedstocks that have been employed in literature as pretreatments methods are presented in Table 2. Lignin is an amorphous and water-insoluble heteropolymer, and as stated earlier, it is composed of phenylpropane units (coniferyl, p-coumaryl and sinapyl alcohol) held together by different linkages as discussed earlier [19]. A simplified diagram of biomass pretreatment techniques showing the major components of lignocellulose is presented in this chapter (Figure 4). The fermentation of LB is difficult due to the high recalcitrant lignin and inadequate accessibility to sites for enzyme activity. Studies have shown that irrespective of its solubilization, the lignin content change is related to the solidification and re-deposition which is due to cooling after severe pre-treatment. Therefore, only re-allocation of lignin takes place, instead of lignin removal during pre-treatment at high temperatures and pressures [21]. Lignin inhibits hydrolysis by forming physical barriers and non-productive adsorption of cellulase enzymes. Thus, lignin restricts the enzymes from reaching the cellulose, thereby reducing the active enzyme sites for cellulose hydrolysis. Brandt et al. [20] observed that 80–90% of lignin was recovered from a solid fraction of hardwood through hydrothermal pre-treatment at 180–220°C. Therefore, as the severity of hydrothermal pre-treatment increases, the lignin content in the pre-treated solids also increases due to the simultaneous de- and re-polymerization reactions of lignin. Some pretreatment methods are summarized in the following sections.
Pre-treatment methods | Feedstocks | References |
---|---|---|
Hydrothermal | Sugarcane bagasse | [23] |
Ultrasonic | Sugarcane bagasse | [24] |
Ionic liquids | Water hyacinth | [25, 26] |
Hydrothermal | Sugarcane bagasse | [14] |
Alkali | Cattle dung | [27] |
Thermochemical | Water hyacinth | [28] |
Feedstocks and pretreatment methods.
Simplified diagram of biomass pretreatment technique showing the major components of lignocellulose (Accessed at:
During hydrothermolysis, the lignocellulosic changes that occur for bioenergy production were found to be an efficient method to disrupt lignin and hemicellulose and expose cellulose [20]. The authors [20] concluded that it is impossible for this pretreatment method to completely remove all the lignin present in a lignocellulosic feedstock. In the hydrothermolysis of sunflower oil cake for 1, 2, 4 and 6 h intervals at 25–200°C, it was observed that the cellulose solubilization rate was low (5%) while the hemicellulose content decreased from 13 to 6% at 200°C [29]. In the case of wheat straw at 200°C, cellulose crystallinity reduced as the cellulose hydrolysis rate was increased [30]. Lignin repolymerization occurred at 140°C -180°C for wood in 12–192 minutes with a removal of 75% of lignin [31]. Biogas production from sugarcane bagasse by hydrothermolysis was studied [25]. The authors [25] finding was that pretreatment by hydrothermolysis increased the biogas yield by approximately 15%.
The search for a green solvent such as ionic liquids (IL) in the pretreatment of LB for biofuel production has gained increasing recognition for decades. ILs do solubilize complex biomass, thus providing industrial scale-up potential [23]. The unique abilities of ILs to selectively dissolve components of biomass or whole native biomass have been demonstrated [24]. Most ILs have been reported to be viscous in nature, requiring the use of co-solvents to enhance its fluidity and the recovery by a commonly employed aqueous biphasic system, or the use of acetone, sodium hydroxide or water [25]. Commonly used co-solvents are dimethyl sulfoxide (DMSO) and dimethylacetamide (DMAC). The application of ILs to LB in areas such as fractionation, cellulose composites preparation and its derivative and removal of pollutants is a new avenue for the efficient utilization of these solvents [26]. ILs have been found to be the most expensive research-grade solvents under investigation for the dissolution of biomass and provides further challenges with solvent recovery [20].
Lignocellulosic pretreatment with acids at ambient temperatures are carried out to enhance hemicellulose solubilization, thereby, making cellulose accessible for enzyme degradation with a dilute or a strong acid [14]. In this process, solubilized hemicelluloses are exposed by hydrolytic reactions to produce monomers, furfural, and other volatile products under acidic conditions [27]. In this regard, solubilized lignin quickly condenses and precipitates into acidic conditions. Hemicellulose solubilization and lignin precipitation are therefore noticeable during strong acid pretreatment. A disadvantage of this method is the risk of the formation of inhibiting compounds [14]. However, the use of dilute acid pretreatment has gained numerous research interests over the use of concentrated acids [28]. This is due to the fact that concentrated acids are toxic, corrosive, hazardous, and require reactors that need expensive construction materials which are resistant to corrosion.
The delignification of LB could also involve application of biological methods using enzymes or microorganisms. Wood degrading microbes including white, brown, soft rot fungi, and bacteria are used in biological applications [28]. Biodegradation releases the chemical components and opens up the structure of the LB which promotes enzyme action leading to further breakdown. The brown and soft rots have been reported to attack cellulose leading to lignin modifications, whilst the lignin components are degraded by the white rot fungi [28]. The biological pretreatment of wood chips with four different white-rot fungi for a period of 30 days was studied [3]. The glucose yield of the pretreated wood by
Microalgae have the capacity to adapt to changes in the environment, producing biomass that serves as a precursor for a variety of biomolecules; such as proteins, pigments, vitamins, lipids, and carbohydrates, in addition to finding applications in pharmaceutical, cosmetic, food and biofuel industries [32]. In Figure 5, a process flow diagram for micro-algal system in a combined biofuel production system is presented. Microalgae have a promising physiological plasticity in that they have a wide range of pH which allows for a range of species that can convert biomass to high value applications [33]. Pollutants in wastewaters present themselves as nutrients to microalgae, thus providing application of microalgae technology in the wastewater treatment sector. These photosynthetic organisms grow under diverse luminous intensities and electromagnetic radiations to produce biomass of desired compositions. In addition, they sequester CO2 from the environment and contribute to the global CO2 balance, thus addressing the global warming phenomenon induced by emissions from fossil fuel combustion processes. Microalgae cultivation combined with metabolic techniques range from autotrophy and heterotrophy to mixotrophy, allowing the biomass a wide latitude for varied specific growth rate, productivity, and composition, which in turn can be enhanced by the hydrodynamics that are governed by the reactor configurations. Lipid recovery continues to be a significant bottleneck in biodiesel production due to high costs of harvesting the biomass in the first instance and the available lipid extraction techniques [34]. Microalgae growth is induced and sustained by factors such as (i) thermal energy, (ii) inorganic carbon supply, (iii) nutrient availability, (iv) luminous exposure, (v) organic carbon and (vi) water. Under photosynthesis protocol, these factors usually work in combination through different metabolic scenarios, which include autotrophy, heterotrophy and mixotrophy. The response to these factors and the nutritional programs depends on the microalgae species and strains. However, the quality of biomass produced from these photosynthetic metabolic scenarios depends on the hydrodynamic stress of the cultivation system [35].
Process flow for a micro-algal system for combined biofuels production, CO2 biomitigation, and N/P removal from wastewater [
Most microalgae species are mesophilic in nature as they produce biomass in the temperature range of 15–35°C. However, some species are extremophiles, i.e. some strains are psychrophilic (
Inorganic carbon that is accessible to microalgae is mostly CO2 gas. This gas is available in dilute concentrations in the atmosphere at 0.035 mole percent (dry basis) [38]. Microalgae absorb CO2 from the atmosphere to produce sugars by the physiochemical process of photosynthesis. The biological conversion of CO2 results in products of the photosynthetic metabolism such as cells, oxygen biopolymers which are soluble in the culture medium and volatile organic compounds (VOC’s). Zhao and Su [39] described photosynthesis as a two-stage process. The first stage is the light-dependent reaction which captures the energy of light for oxidative phosphorylation in the metabolic cycle that produces the energy-storage molecules, adenosine triphosphate (ATP) and nicotinamide adenine dinucleotide phosphate (NADPH) as shown in Eq. (1).
Eq. (2) shows the second-stage reaction, which is carbon dioxide fixation; and it is not directly light-dependent. This photosynthetic dark-reaction captures and reduces carbon dioxide to carbohydrates and releases molecular oxygen [40].
With a solubility of 0.1449 g CO2/100 mL H2O at 25°C and 101.325 kPa vapor pressure, carbon dioxide gas dissolves in surface water and slowly reacts with water to alter its chemistry as shown in Eqs. (3) and (4).
The release of H+ ion in Eq. (4) causes the reduction in pH of the culture medium. However, the ability to thrive in a wide pH range has given microalgae the privilege to access nutrients from municipal and industrial wastewaters. In the presence of hydroxide ions, carbonate ions are also released as in Eq. (5).
When the dynamic ionization equilibrium is attained, dissolved inorganic carbon (DIC) is available in the form of CO2, HCO3−, CO32−, and H2CO3. However, only CO2 and HCO3− are accessible to microalgae and both species are utilized simultaneously to produce biomass [41]. The CO2 conversion into biomass is increased only under conditions where the CO2 mass loading rate is low. At a high CO2 mass loading rate, the formation of VOCs is the main CO2 biotransformation strategy [33].
Standard microalgae culture media have been developed and produced out of the need to produce desired products and are available in the market for freshwater microalgae growth management. Some of the media are the (i) Blue-Green medium, BG-11 (ii) Bold’s Basal medium, BBM (iii) Bold’s Basal medium modified, BBM-3 N (iv) CHU 13 and (v) Jaworski’s Medium, JM. Both municipal and industrial wastewater have the basic nutrients common to all the artificial media designed for microalgae cultivation; and microalgae access these nutrients as nitrates and reactive phosphates from wastewaters to produce biomass and bio-products [42, 43].
Microalgae have three different metabolic pathways, namely, autotrophy, heterotrophy and mixotrophy. While all algae species are autotrophic, some stains have the ability to exhibit heterotrophy and mixotrophy; and any of the chosen photosynthetic metabolic depends on the microalgae species, and the quality of the biomass desired. Autotrophic metabolism utilizes inorganic carbon in the form of CO2, gas and light energy. This mode of fixing CO2 produces low density microalgal biomass. Heterotrophic metabolism takes advantage of the presence of organic carbon and utilizes it both as a source of carbon and energy. This is the dominant pathway during the night or dark phases. Some microalgae do metabolize mixotrophically. Under mixotophic mode, light energy is not the absolute growth limiting factor as organic carbon sources are also accessed and utilized for microalgal biomass production. Photoinhibition, a phenomenon that describes excessive light intensity thereby arresting photosynthetic metabolism, is overcome under the mixotrophic metabolic mode. Consequently, the growth rate is not interrupted and high density biomass is produced with recorded higher productivities when compared to autotrophic and heterotrophic metabolic scenarios [6].
Organic carbon present in municipal and industrial wastewater are carbohydrates, fats, volatile fatty acids (VFAs), soaps, synthetic detergents, lignin, proteins and their decomposition products; as well as various natural and synthetic organic chemicals. Wastewater treatment and concomitant algal biofuel production has received increasing attention in recent years owing to its diverse environmental and economic benefits [44]. Organic carbon is accessible through monosodium glutamate wastewater, cheese whey permeates, sodium acetate, fruit peel, glucose, fructose, glycerol, etc. via mixotrophic microalgal growth mode. Tan and co-workers [45] reported that productivities of
Biotransformation kinetics in microalgae are driven by two cultivation systems: (i) open cultivation systems, (OCS) and (ii) closed cultivation systems, (CCS). Open cultivation systems employ open ponds, tanks and raceway ponds while the closed cultivations system utilizes closed photobioreactors (PBR), such as bubble column reactors (BCR), airlift reactors (ALR), tubular reactors (TR), plastic bag (single-use) reactors (SUR), stirred tank reactors (STR), and plate reactors (PR). The OCS attracts minimal capital, operating cost, and lesser energy for culture mixing. However, OCS require large land-mass for scale-up operations as they are prone to contamination and adverse weather conditions wherein they suffer evaporation and temperature fluctuations [47]. The CCS on the other hand, are operated at highly controlled conditions and are more efficient in terms of quality. PBRs can be designed and optimized to cultivate a chosen microalgal strain; since they occupy minimal landmass with enhanced luminous exposure to the microalgae cells and encounter little or no contamination. However, PBRs do have bio-fouling issues, cleaning difficulties, benthic microalgal growth, and high build-up of dissolved oxygen (DO) leading to growth obstructions, and high capital cost [48, 49].
The microalgae culture mixing regimes may vary from one PBR to another, and since the purpose of mixing is to ensure adequate exposure of all the microalgae cells to the growth index, variables such as thermal energy, nutrients adequate illumination, gas exchange, and the quality of microalgal biomass churned from each PBR varies in terms of cell density and biomass composition [50].
PBRs using microalgae to treat wastewater and to produce biomolecules are based on five basic criteria: (i) full control of the reaction conditions, (ii) increased efficient use of light energy, (iii) an adequate mixing system, (iv) reduced hydrodynamic stress on the cells and (v) flexible scale-up operations [51].
Biomass productivity depends largely on the quantity and quality of light available to microalgae cells during exponential growth, especially in the autotrophic metabolic mode. Lighting has a great influence on the synthesis of co-products in microalgal biomass as the cells increase pigmentation. Large quantities of solar radiation storage are enhanced as biomass, which can be transformed into solid, liquid, or gaseous fuels [52]. On the other hand, the exposition of microalgae cells to excessive illumination can cause photoinhibition, a phenomenon which describes termination of photocatalytic activity in the presence of illumination. Both photoperiod and light intensity influence microalgal growth, pigment production, biomass, and lipid productivities. High biomass and lipid productivities have been reported for stepwise strategic light-intensity increases during mixotrophic cultivation of microalgae. Cheirsilp and Torpee [53] reported the influence of light intensity on the growth and lipid accumulation of marine
Generation of bioenergy from biomass is achieved in various ways and may be classified into three main categories, namely, physio-chemical, bio-chemical, and thermo-chemical processes [54]. The following are common techniques utilized in the conversion of biomass into biofuels, i.e. mechanical extraction, transesterification, pyrolysis, anaerobic digestion, fermentation, gasification, liquefaction, and fuel cell systems as shown in Figure 6. This subsection gives an overview of the conversion process, the factors affecting each process and the main products derived.
Biomass conversion techniques.
Prior to the application of a specific technique of biofuel generation from biomass, various pre-treatment or pre-processing steps may be carried out to aid effective conversion. Two main pre-treatment methods broadly classified under physio-thermal and chemical methods are usually applied based on the lignocellulosic substrates as discussed in the latter sections on lignocellulosic and the related conversion techniques. Processes such as drying, sizing, crushing, powdering, pelletizing, torrefaction and heating are common physio-thermal methods for pre-treatment of lignocellulosic and algae biomass.
This involves the mechanical extraction of oil from lignocellulosic and algae biomass, where the oil produced is further esterified to produce biodiesel. Biodiesel is usually blended with conventional diesel to be used as fuel for motor vehicles. The oil extracted from the biomass is highly viscous with polyunsaturated characteristics; therefore, transesterification processes which utilize either acids, bases, or enzymes as catalysts, convert the oil into fatty acid methyl esters (FAME) or fatty acid alkyl esters with glycerol as by-product. The esters produced from the transesterification process have lower viscosities and are comparable to conventional fuels [51].
The biochemical conversion process utilizes the metabolic activity of microorganism for conversion of biomass into biofuel and by-products. Biomass conversion is environmentally friendly when compared to thermochemical methods where the residence time for the conversion process to be achieved is longer when compared to thermochemical conversion means. The main biochemical conversion methods are discussed below.
Anaerobic digestion (AD) is the microbial degradation of organic matter in the absence of oxygen to produce mainly biogas (biomethane and carbon dioxide). The conversion of organic matter into biogas is presented in Figure 7. It is a series of biochemical reactions where microorganisms anaerobically convert organic materials into products to be finally converted into biogas [2].
Anaerobic digestion degradation process.
Microorganisms break down high molecular mass compounds such as polysaccharides, proteins, fats, cellulose, and hemicellulose into smaller molecular mass compounds which are later converted into biogas. The efficiency of AD processes is dependent on the components of the substrate and the activity of microorganisms. AD is a biochemical conversion process that is robust with proven reliable applications. AD has been widely applied in the treatment of organic waste streams, and its development for production of biogas goes far back as the 16th century [55]. The general equation to produce methane from organic matter is given as in Eq. (6).
The four main stages involved in the AD of lignocellulosic biomass are hydrolysis, acetogenesis, acidogenesis and methanogenesis. Theses stages occur successively as the product from a preceding stage is utilized in the next stage. Hydrolysis is the first stage in the AD process, and it involves the breakdown of high molecular mass compounds into smaller ones. This stage is followed by acidogenesis, which is the conversion of the smaller molecular compounds into identifiable lower molecular compounds. The acetogenesis stage converts the volatile fatty acids (VFAs) from acidogenesis into acetate, CO2 and H2, where after these intermediate compounds are converted into methane and CO2 with other by-products in trace amounts in methanogenesis stage, with the aid of methanogens. The stages of the AD process are affected by various parameters and the biomass chosen.
The conversion of biomass to simple sugars with subsequent transformation into alcohol and CO2 with the aid of microorganisms, mainly, yeasts is known as fermentation. This process has been applied for centuries to produce ethanol from sugar crops. It has been used for conversion of lignocellulosic material and algae to ethanol. The by-product from this process after the distillation process are the non-fermentable products which are further directed for use as animal-feed, or as raw feed for the thermochemical conversion. Ethanol produced from the process can be used as fuel for motor vehicles, or as compliment for existing conventional fuels. It has been used as an additive for petrol to improve the octane rating and vehicle emissions reduction in countries such as Australia, Brazil, Sweden, and United States [20]. Anaerobic or dark fermentation of pre-treated lignocellulosic biomass is used in the production of biohydrogen, where the process is like the acidogenic stage in AD. The microorganisms used in this process are mainly hydrogen producing microbes such as
MFCs employ the activity of micro-organisms to convert pre-treated biomass into bioelectricity that can be fed into an existing electricity grid. The process involves the oxidation of the substrates (cellulosic biomass) at the anode chamber of the cell by microorganisms, (electrode-reducing organisms) to electrons which are transferred to the cathode chamber through a conductive material. In the cathode region, the electrode-oxidizing organisms utilize the electrons for reduction of various compounds to other forms (such as CO2 to acetate, nitrate to N2 and O2 to H2O). It is an electrochemical reaction that utilizes microorganisms for catalysis; therefore, it is referred to as a bioelectrochemical process. The anode in an MFC is usually carbon based such as carbon cloth, felt, fiber, rod, and paper, while the cathode is either of the latter coated with platinum [57, 58]. Figure 8 shows a schematic of the working principles of a microbial fuel cell. The catalyst used may differ based on the application of the fuel cell.
Schematic of a microbial fuel cell.
Thermochemical conversion techniques involve the use of heat or chemicals for the conversion of biomass into fuel and heat (as in the case of combustion and gasification). The thermochemical means is sometimes preferred since it requires limited time, little or no pre-treatment, and generation of variable end-products as compared to biochemical means. The overview of the main thermochemical conversion techniques is summarized in the following section.
An irreversible chemical reaction impacted by heat in the absence of oxygen is known as pyrolysis. This method generally converts lignocellulosic biomass into solid, liquid, and gaseous fractions which are further processed into another product spectrum [59]. Pyrolysis is commonly adopted, since its end-product ranges from gaseous to solid fuels in varying percentages, when compared to other thermochemical biomass conversion methods. Pyrolysis can be a precursor to some other conversion processes such as gasification and combustion, as well as a succeeding step to some pre-treatment methods, such as torrefaction and degradative solvent extraction (DSE) [60]. Pyrolysis is a temperature, heating rate and time dependent process, and varying these conditions with addition of selected catalysts give a specified, desired end-product. Based on the specific conditions, pyrolysis is classified into slow, intermediate, and fast mode; and from which different percentages of solid, liquid, and gaseous product are derived. The classification of pyrolysis base on temperature and residence time is shown in Table 3, and it ranges from the low temperatures (~ 300°C) to high temperatures (approximately 900°C).
Mode of pyrolysis | Heating rate | Temperature | Residence time | Product percent by weight (% wt) | ||
---|---|---|---|---|---|---|
Solid | Liquid | Gas | ||||
Slow | 250–400°C | Long hours to days | ||||
Carbonization | Low | ~400°C* | 35 | 30 | 35 | |
Torrefaction Intermediate | ~280°C | 10–60 mins | 80 | 3 | 20 | |
Medium | 300–500°C | 5–30 s | 25 | 50 | 25 | |
Fast | High | ~500°C | < 2 s | 12 | 75 | 13 |
Slow pyrolysis involves lower heating rates between 0.1 and 2°C, and the products are mainly solids. Carbonization is a form of slow pyrolysis which is the old technique used in the production of charcoal (biochar) and the vapor produced during the process is usually not condensed, but rather used for heating. Torrefaction mainly aims at improving the energy density and biomass fuel properties, such as reduced weight and volume, which renders the fuel easy to transport and be crushed when needed. The intermediate pyrolysis process produces less solid and liquid with low viscosities. Fast pyrolysis is one of the biomass conversion technologies currently gaining prominence because of its ability to generate more liquid fuel (bio-oil) which could be easily upgraded to diverse valuable products, and transported [19, 61].
Gasification is the conversion of biomass or carbonaceous feedstock into gaseous components at temperatures higher than 650°C. The gaseous component of the gasification process may vary depending on the operating temperature. At a lower temperatures below 1200°C, gas constituents may vary from CO, CO2, CH4 and H2, which are collectively known as producer gas while at a higher temperatures, the constituents are CO and H2, which are collectively known as synthesis gas or syngas [62]. Coal gasification is a well-known process in the generation of electricity which can also be used for biomass conversion into gas. The four steps involved in the gasification process are drying or heating, pyrolysis, gas–solid reaction, and gas phase reaction. These steps occur successively and may take a fraction of a minute depending on the reactor (gasifier) design [52]. Drying/heating is mainly adopted to remove the moisture content of biomass, thereby converting the biomass into dry mass. This is done to attain the required temperature for gasification and the desired products. This process is followed by pyrolysis. The gas–solid reaction step involves the reaction of the gas and solid (char) produced from the pyrolysis phase. The char which is carbon reacts with carbon dioxide, hydrogen, oxygen, and water (vapor) to form gaseous compounds as shown in the conversion Eqs. (7)–(10).
Thus, the gas phase reaction is shown in Eqs. (11)–(12).
This is the conversion of biomass into liquid or solubilized products at moderate temperatures (105–400°C) and pressure (2–20 MPa) with the aid of solvents. Solvents such as water, ethanol, phenol, tetralin, sulfuric acid, phosphoric acid, nitric acid, and other ionic solvents have been utilized. When water is used as the solvent in the liquefaction process, it is known as hydrothermal liquefaction [63]. For optimal efficiency of the process, the main parameter is the choice of solvent as the process requires the solvent to be in the liquid phase during the reaction. Solvents such as creosote have been utilized to achieve a bio-oil yield of 74 wt% as compared to water of 35 wt% yield or acetone of 10 to 60 wt% yield, for lignocellulosic biomass. This process has been mainly used for the processing of lignocellulosic biomass, algae, and other biomass feedstocks. Unlike other thermochemical conversion processes, this process does not need much residence time for intermediate drying/heating of the biomass as it could be used to process biomass with 15 to 80% moisture content.
Combustion is the complete oxidation of carbon containing materials to CO2 and H2O in the presence of air (oxygen). For a complete combustion process, the four stages involved are heating or drying, pyrolysis, volatiles combustion (known as flaming) and char combustion (smoldering). These stages are similar to the stages in gasification and the only difference is that combustion requires excess air [64]. Combustion depends on the operating temperature, feedstock type, the particle size of the feedstock, the design of the reactor and atmospheric conditions. Other by-products of this process are nitrogen oxides, sulfur, ash, and particulate matter which are environmentally unfriendly [63].
The conversion of LB into value-added products is vital to meet the global demand for lignocellulosic products. The concept of biorefining arose since the potential of lignocellulosic and microalgae-based products were substituted for fossil fuel derived products, which accounted for increased usage of non-renewable fuels. The reduction in the demand on fossils, creation of opportunities in the job market and the provision of sustainable forms of energy has highlighted the role of biorefineries in tackling climate change. This chapter presented the insights into the various components of lignocellulose and microalgae, the pretreatment techniques adopted in the past decades for delignification and conversion into useful products, and the applications coupled with future prospects for valorization of biomass.
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Integrity - We are consistent and dependable, always striving for precision and accuracy in the true spirit of science.
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\n\nIntechOpen is a dynamic, vibrant company, where exceptional people are achieving great things. We offer a creative, dedicated, committed, and passionate environment but never lose sight of the fact that science and discovery is exciting and rewarding. We constantly strive to ensure that members of our community can work, travel, meet world-renowned researchers and grow their own career and develop their own experiences.
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Clonal complex 398 (CC398), a predominant clonal lineage of livestock-associated-MRSA in domestic animals and retail meat, is capable of infecting humans. In order to monitor and prevent MRSA contamination, it is critical to understand its source and transmission dynamics. In this review, we describe MRSA in food-producing animals (pig, cattle, chicken), horses, pet animals (dogs, cats), and food products (pork, beef, chicken, milk, and fish).",book:{id:"5471",slug:"frontiers-in-i-staphylococcus-aureus-i-",title:"Frontiers in Staphylococcus aureus",fullTitle:"Frontiers in Staphylococcus aureus"},signatures:"Jungwhan Chon, Kidon Sung and Saeed Khan",authors:[{id:"189634",title:"Dr.",name:"Kidon",middleName:null,surname:"Sung",slug:"kidon-sung",fullName:"Kidon Sung"},{id:"190400",title:"Dr.",name:"Jungwhan",middleName:null,surname:"Chon",slug:"jungwhan-chon",fullName:"Jungwhan Chon"},{id:"190401",title:"Dr.",name:"Saeed",middleName:null,surname:"Khan",slug:"saeed-khan",fullName:"Saeed Khan"}]}],mostDownloadedChaptersLast30Days:[{id:"69731",title:"Isolation and Purification of Sulfate-Reducing Bacteria",slug:"isolation-and-purification-of-sulfate-reducing-bacteria",totalDownloads:1526,totalCrossrefCites:1,totalDimensionsCites:6,abstract:"Sulfate-reducing bacteria (SRB) are a widespread group of microorganisms that are often isolated from the anoxygenic environments (lake depths, soil, or swamps), and they are also present in the human and animal intestines. This group is often detected in patients with inflammatory bowel disease, including ulcerative colitis. That is why new rapid methods for their isolation, purification, and identification are important and necessary. In this chapter, the methods of mesophilic SRB isolation from various environments are described. Particular attention is paid to the purification of mesophilic SRB since they can be in close interaction with other microorganisms (Clostridium, Bacteroides, Pseudomonas, etc.), which are their frequent satellites. Moreover, the main methods of mesophilic SRB identification based on their morphological, physiological, biochemical, and genetical characteristics are presented.",book:{id:"8997",slug:"microorganisms",title:"Microorganisms",fullTitle:"Microorganisms"},signatures:"Ivan Kushkevych",authors:[{id:"252191",title:"Associate Prof.",name:"Ivan",middleName:null,surname:"Kushkevych",slug:"ivan-kushkevych",fullName:"Ivan Kushkevych"}]},{id:"65773",title:"Life Cycle of Trypanosoma cruzi in the Invertebrate and the Vertebrate Hosts",slug:"life-cycle-of-em-trypanosoma-cruzi-em-in-the-invertebrate-and-the-vertebrate-hosts",totalDownloads:1450,totalCrossrefCites:4,totalDimensionsCites:7,abstract:"Trypanosoma cruzi (T. cruzi) is a protozoan parasite that causes Chagas disease, a zoonotic disease that can be transmitted to humans by blood-sucking triatomine bugs. T. cruzi is a single-celled eukaryote with a complex life cycle alternating between reduviid bug invertebrate vectors and vertebrate hosts. This article will look at the developmental stages of T. cruzi in the invertebrate vector and the vertebrate hosts, the different surface membrane proteins involved in different life cycle stages of T. cruzi, roles of different amino acids in the life cycle, carbon and energy sources and gene expression in the life cycle of T. cruzi. The author will also look at extracellular vesicles (EV) and its role in the dissemination and survival of T. cruzi in mammalian host.",book:{id:"8806",slug:"biology-of-em-trypanosoma-cruzi-em-",title:"Biology of Trypanosoma cruzi",fullTitle:"Biology of Trypanosoma cruzi"},signatures:"Kenechukwu C. Onyekwelu",authors:[{id:"245368",title:"Dr.",name:"Kenechukwu C.",middleName:null,surname:"Onyekwelu",slug:"kenechukwu-c.-onyekwelu",fullName:"Kenechukwu C. Onyekwelu"}]},{id:"54154",title:"Staphylococcus aureus: Overview of Bacteriology, Clinical Diseases, Epidemiology, Antibiotic Resistance and Therapeutic Approach",slug:"staphylococcus-aureus-overview-of-bacteriology-clinical-diseases-epidemiology-antibiotic-resistance-",totalDownloads:7155,totalCrossrefCites:14,totalDimensionsCites:25,abstract:"Staphylococcus aureus is an important human pathogen that causes wide range of infectious conditions both in nosocomial and community settings. The Gram-positive pathogen is armed with battery of virulence factors that facilitate to establish infections in the hosts. The organism is well known for its ability to acquire resistance to various antibiotic classes. The emergence and spread of methicillin-resistant S. aureus (MRSA) strains which are often multi-drug resistant in hospitals and subsequently in community resulted in significant mortality and morbidity. The epidemiology of MRSA has been evolving since its initial outbreak which necessitates a comprehensive medical approach to tackle this pathogen. Vancomycin has been the drug of choice for years but its utility was challenged by the emergence of resistance. In the last 10 years or so, newer anti-MRSA antibiotics were approved for clinical use. However, being notorious for developing antibiotic resistance, there is a continuous need for exploring novel anti-MRSA agents from various sources including plants and evaluation of non-antibiotic approaches.",book:{id:"5471",slug:"frontiers-in-i-staphylococcus-aureus-i-",title:"Frontiers in Staphylococcus aureus",fullTitle:"Frontiers in Staphylococcus aureus"},signatures:"Arumugam Gnanamani, Periasamy Hariharan and Maneesh Paul-\nSatyaseela",authors:[{id:"192829",title:"Dr.",name:"Arumugam",middleName:null,surname:"Gnanamani",slug:"arumugam-gnanamani",fullName:"Arumugam Gnanamani"},{id:"204388",title:"Dr.",name:"Periasamy",middleName:null,surname:"Hariharan",slug:"periasamy-hariharan",fullName:"Periasamy Hariharan"},{id:"204389",title:"Dr.",name:"Maneesh",middleName:null,surname:"Paul-Satyaseela",slug:"maneesh-paul-satyaseela",fullName:"Maneesh Paul-Satyaseela"}]},{id:"55437",title:"Biological Control of Parasites",slug:"biological-control-of-parasites-2017-07",totalDownloads:4281,totalCrossrefCites:7,totalDimensionsCites:7,abstract:"Parasites (ectoparasites or endoparasites) are a major cause of diseases in man, his livestock and crops, leading to poor yield and great economic loss. To overcome some of the major limitations of chemical control methods such as rising resistance, environmental and health risks, and the adverse effect on non‐target organisms, biological control (biocontrol) is now at the forefront of parasite (pests) control. Biocontrol is now a core component of the integrated pest management. Biocontrol is defined as “the study and uses of parasites, predators and pathogens for the regulation of host (pest) densities”. Considerable successes have been achieved in the implementation of biocontrol strategies in the past. This chapter presents a review of the history of biocontrol, its advantages and disadvantages; the different types of biological control agents (BCAs) including predators, parasites (parasitoids) and pathogens (fungi, bacteria, viruses and virus‐like particles, protozoa and nematodes); the effect of biocontrol on native biodiversity; a few case studies of the successful implementation of biocontrol methods and the challenges encountered with the implementation of biocontrol and future perspectives.",book:{id:"5527",slug:"natural-remedies-in-the-fight-against-parasites",title:"Natural Remedies in the Fight Against Parasites",fullTitle:"Natural Remedies in the Fight Against Parasites"},signatures:"Tebit Emmanuel Kwenti",authors:[{id:"191763",title:"Dr.",name:"Tebit Emmanuel",middleName:null,surname:"Kwenti",slug:"tebit-emmanuel-kwenti",fullName:"Tebit Emmanuel Kwenti"}]},{id:"70336",title:"Plastics Polymers Degradation by Fungi",slug:"plastics-polymers-degradation-by-fungi",totalDownloads:1416,totalCrossrefCites:3,totalDimensionsCites:6,abstract:"The studies on plastic degradation are very important for the development of biodegradable plastics, and for reduction of pollution, since plastic waste can remain in the environment for decades or centuries. We have showed the degradation of oxo-biodegradable plastic bags and green polyethylene by Pleurotus ostreatus. This fungus can also produce mushrooms using these plastics. The plastic degradation was possibly by three reasons: (a) presence of pro-oxidant ions or plant polymer, (b) low specificity of the lignocellulolytic enzymes, and (c) the presence of endomycotic nitrogen-fixing microorganisms. In this chapter, the plastic bags’ degradation by abiotic and microbial process using the exposure to sunlight and the use of a white-rot fungus will described. The physical, chemical, and biological alterations of plastic were analyzed after each process of degradation. The degradation of plastic bags was more effective when the abiotic and biotic degradations were combined.",book:{id:"8997",slug:"microorganisms",title:"Microorganisms",fullTitle:"Microorganisms"},signatures:"José Maria Rodrigues da Luz, Marliane de Cássia Soares da Silva, Leonardo Ferreira dos Santos and Maria Catarina Megumi Kasuya",authors:[{id:"217699",title:"Dr.",name:"Jose Maria",middleName:null,surname:"Da Luz",slug:"jose-maria-da-luz",fullName:"Jose Maria Da Luz"}]}],onlineFirstChaptersFilter:{topicId:"151",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:89,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:32,numberOfPublishedChapters:318,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:106,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:5,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:15,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. This Biochemistry Series will address the current research on biomolecules and the emerging trends with great promise.",coverUrl:"https://cdn.intechopen.com/series/covers/11.jpg",latestPublicationDate:"June 29th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:32,editor:{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",slug:"miroslav-blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:4,paginationItems:[{id:"14",title:"Cell and Molecular Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",isOpenForSubmission:!0,editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",slug:"rosa-maria-martinez-espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",biography:"Dr. Rosa María Martínez-Espinosa has been a Spanish Full Professor since 2020 (Biochemistry and Molecular Biology) and is currently Vice-President of International Relations and Cooperation development and leader of the research group 'Applied Biochemistry” (University of Alicante, Spain). Other positions she has held at the university include Vice-Dean of Master Programs, Vice-Dean of the Degree in Biology and Vice-Dean for Mobility and Enterprise and Engagement at the Faculty of Science (University of Alicante). She received her Bachelor in Biology in 1998 (University of Alicante) and her PhD in 2003 (Biochemistry, University of Alicante). She undertook post-doctoral research at the University of East Anglia (Norwich, U.K. 2004-2005; 2007-2008).\nHer multidisciplinary research focuses on investigating archaea and their potential applications in biotechnology. She has an H-index of 21. She has authored one patent and has published more than 70 indexed papers and around 60 book chapters.\nShe has contributed to more than 150 national and international meetings during the last 15 years. Her research interests include archaea metabolism, enzymes purification and characterization, gene regulation, carotenoids and bioplastics production, antioxidant\ncompounds, waste water treatments, and brines bioremediation.\nRosa María’s other roles include editorial board member for several journals related\nto biochemistry, reviewer for more than 60 journals (biochemistry, molecular biology, biotechnology, chemistry and microbiology) and president of several organizing committees in international meetings related to the N-cycle or respiratory processes.",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"15",title:"Chemical Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",isOpenForSubmission:!0,editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",slug:"sukru-beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",biography:"Dr. Şükrü Beydemir obtained a BSc in Chemistry in 1995 from Yüzüncü Yıl University, MSc in Biochemistry in 1998, and PhD in Biochemistry in 2002 from Atatürk University, Turkey. He performed post-doctoral studies at Max-Planck Institute, Germany, and University of Florence, Italy in addition to making several scientific visits abroad. He currently works as a Full Professor of Biochemistry in the Faculty of Pharmacy, Anadolu University, Turkey. Dr. Beydemir has published over a hundred scientific papers spanning protein biochemistry, enzymology and medicinal chemistry, reviews, book chapters and presented several conferences to scientists worldwide. He has received numerous publication awards from various international scientific councils. He serves in the Editorial Board of several international journals. Dr. Beydemir is also Rector of Bilecik Şeyh Edebali University, Turkey.",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",slug:"deniz-ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",biography:"Dr. Deniz Ekinci obtained a BSc in Chemistry in 2004, MSc in Biochemistry in 2006, and PhD in Biochemistry in 2009 from Atatürk University, Turkey. He studied at Stetson University, USA, in 2007-2008 and at the Max Planck Institute of Molecular Cell Biology and Genetics, Germany, in 2009-2010. Dr. Ekinci currently works as a Full Professor of Biochemistry in the Faculty of Agriculture and is the Head of the Enzyme and Microbial Biotechnology Division, Ondokuz Mayıs University, Turkey. He is a member of the Turkish Biochemical Society, American Chemical Society, and German Genetics society. Dr. Ekinci published around ninety scientific papers, reviews and book chapters, and presented several conferences to scientists. He has received numerous publication awards from several scientific councils. Dr. Ekinci serves as the Editor in Chief of four international books and is involved in the Editorial Board of several international journals.",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null},{id:"17",title:"Metabolism",coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",isOpenForSubmission:!0,editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",slug:"yannis-karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",biography:"Yannis Karamanos, born in Greece in 1953, completed his pre-graduate studies at the Université Pierre et Marie Curie, Paris, then his Masters and Doctoral degree at the Université de Lille (1983). He was associate professor at the University of Limoges (1987) before becoming full professor of biochemistry at the Université d’Artois (1996). He worked on the structure-function relationships of glycoconjugates and his main project was the investigations on the biological roles of the de-N-glycosylation enzymes (Endo-N-acetyl-β-D-glucosaminidase and peptide-N4-(N-acetyl-β-glucosaminyl) asparagine amidase). From 2002 he contributes to the understanding of the Blood-brain barrier functioning using proteomics approaches. He has published more than 70 papers. His teaching areas are energy metabolism and regulation, integration and organ specialization and metabolic adaptation.",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null},{id:"18",title:"Proteomics",coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",isOpenForSubmission:!0,editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",slug:"paolo-iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",biography:"Paolo Iadarola graduated with a degree in Chemistry from the University of Pavia (Italy) in July 1972. He then worked as an Assistant Professor at the Faculty of Science of the same University until 1984. In 1985, Prof. Iadarola became Associate Professor at the Department of Biology and Biotechnologies of the University of Pavia and retired in October 2017. Since then, he has been working as an Adjunct Professor in the same Department at the University of Pavia. His research activity during the first years was primarily focused on the purification and structural characterization of enzymes from animal and plant sources. During this period, Prof. Iadarola familiarized himself with the conventional techniques used in column chromatography, spectrophotometry, manual Edman degradation, and electrophoresis). Since 1995, he has been working on: i) the determination in biological fluids (serum, urine, bronchoalveolar lavage, sputum) of proteolytic activities involved in the degradation processes of connective tissue matrix, and ii) on the identification of biological markers of lung diseases. In this context, he has developed and validated new methodologies (e.g., Capillary Electrophoresis coupled to Laser-Induced Fluorescence, CE-LIF) whose application enabled him to determine both the amounts of biochemical markers (Desmosines) in urine/serum of patients affected by Chronic Obstructive Pulmonary Disease (COPD) and the activity of proteolytic enzymes (Human Neutrophil Elastase, Cathepsin G, Pseudomonas aeruginosa elastase) in sputa of these patients. More recently, Prof. Iadarola was involved in developing techniques such as two-dimensional electrophoresis coupled to liquid chromatography/mass spectrometry (2DE-LC/MS) for the proteomic analysis of biological fluids aimed at the identification of potential biomarkers of different lung diseases. He is the author of about 150 publications (According to Scopus: H-Index: 23; Total citations: 1568- According to WOS: H-Index: 20; Total Citations: 1296) of peer-reviewed international journals. He is a Consultant Reviewer for several journals, including the Journal of Chromatography A, Journal of Chromatography B, Plos ONE, Proteomes, International Journal of Molecular Science, Biotech, Electrophoresis, and others. He is also Associate Editor of Biotech.",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",slug:"simona-viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",biography:"Simona Viglio is an Associate Professor of Biochemistry at the Department of Molecular Medicine at the University of Pavia. She has been working since 1995 on the determination of proteolytic enzymes involved in the degradation process of connective tissue matrix and on the identification of biological markers of lung diseases. She gained considerable experience in developing and validating new methodologies whose applications allowed her to determine both the amount of biomarkers (Desmosine and Isodesmosine) in the urine of patients affected by COPD, and the activity of proteolytic enzymes (HNE, Cathepsin G, Pseudomonas aeruginosa elastase) in the sputa of these patients. Simona Viglio was also involved in research dealing with the supplementation of amino acids in patients with brain injury and chronic heart failure. She is presently engaged in the development of 2-DE and LC-MS techniques for the study of proteomics in biological fluids. The aim of this research is the identification of potential biomarkers of lung diseases. 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In recent years, the application of chemistry to biological molecules has gained significant interest in medicinal and pharmacological studies. This topic will be devoted to understanding the interplay between biomolecules and chemical compounds, their structure and function, and their potential applications in related fields. Being a part of the biochemistry discipline, the ideas and concepts that have emerged from Chemical Biology have affected other related areas. This topic will closely deal with all emerging trends in this discipline.",annualVolume:11411,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null,editorialBoard:[{id:"219081",title:"Dr.",name:"Abdulsamed",middleName:null,surname:"Kükürt",fullName:"Abdulsamed Kükürt",profilePictureURL:"https://mts.intechopen.com/storage/users/219081/images/system/219081.png",institutionString:null,institution:{name:"Kafkas University",institutionURL:null,country:{name:"Turkey"}}},{id:"241413",title:"Dr.",name:"Azhar",middleName:null,surname:"Rasul",fullName:"Azhar Rasul",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRT1oQAG/Profile_Picture_1635251978933",institutionString:null,institution:{name:"Government College University, Faisalabad",institutionURL:null,country:{name:"Pakistan"}}},{id:"178316",title:"Ph.D.",name:"Sergey",middleName:null,surname:"Sedykh",fullName:"Sergey Sedykh",profilePictureURL:"https://mts.intechopen.com/storage/users/178316/images/system/178316.jfif",institutionString:null,institution:{name:"Novosibirsk State University",institutionURL:null,country:{name:"Russia"}}}]},{id:"17",title:"Metabolism",keywords:"Biomolecules Metabolism, Energy Metabolism, Metabolic Pathways, Key Metabolic Enzymes, Metabolic Adaptation",scope:"Metabolism is frequently defined in biochemistry textbooks as the overall process that allows living systems to acquire and use the free energy they need for their vital functions or the chemical processes that occur within a living organism to maintain life. Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. Thus all studies on metabolism will be considered for publication.",annualVolume:11413,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"243049",title:"Dr.",name:"Anca",middleName:null,surname:"Pantea Stoian",fullName:"Anca Pantea Stoian",profilePictureURL:"https://mts.intechopen.com/storage/users/243049/images/system/243049.jpg",institutionString:null,institution:{name:"Carol Davila University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"203824",title:"Dr.",name:"Attilio",middleName:null,surname:"Rigotti",fullName:"Attilio Rigotti",profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institutionString:null,institution:{name:"Pontifical Catholic University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"300470",title:"Dr.",name:"Yanfei (Jacob)",middleName:null,surname:"Qi",fullName:"Yanfei (Jacob) Qi",profilePictureURL:"https://mts.intechopen.com/storage/users/300470/images/system/300470.jpg",institutionString:null,institution:{name:"Centenary Institute of Cancer Medicine and Cell Biology",institutionURL:null,country:{name:"Australia"}}}]},{id:"18",title:"Proteomics",keywords:"Mono- and Two-Dimensional Gel Electrophoresis (1-and 2-DE), Liquid Chromatography (LC), Mass Spectrometry/Tandem Mass Spectrometry (MS; MS/MS), Proteins",scope:"With the recognition that the human genome cannot provide answers to the etiology of a disorder, changes in the proteins expressed by a genome became a focus in research. Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. The Proteomics topic aims to attract contributions on all aspects of MS-based proteomics that, by pushing the boundaries of MS capabilities, may address biological problems that have not been resolved yet.",annualVolume:11414,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null,editorialBoard:[{id:"72288",title:"Dr.",name:"Arli Aditya",middleName:null,surname:"Parikesit",fullName:"Arli Aditya Parikesit",profilePictureURL:"https://mts.intechopen.com/storage/users/72288/images/system/72288.jpg",institutionString:null,institution:{name:"Indonesia International Institute for Life Sciences",institutionURL:null,country:{name:"Indonesia"}}},{id:"40928",title:"Dr.",name:"Cesar",middleName:null,surname:"Lopez-Camarillo",fullName:"Cesar Lopez-Camarillo",profilePictureURL:"https://mts.intechopen.com/storage/users/40928/images/3884_n.png",institutionString:null,institution:{name:"Universidad Autónoma de la Ciudad de México",institutionURL:null,country:{name:"Mexico"}}},{id:"81926",title:"Dr.",name:"Shymaa",middleName:null,surname:"Enany",fullName:"Shymaa Enany",profilePictureURL:"https://mts.intechopen.com/storage/users/81926/images/system/81926.png",institutionString:"Suez Canal University",institution:{name:"Suez Canal University",institutionURL:null,country:{name:"Egypt"}}}]}]}},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"chapter.detail",path:"/chapters/40210",hash:"",query:{},params:{id:"40210"},fullPath:"/chapters/40210",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()