Optical performance of the RoFSO optical antenna in design condition
\\n\\n
Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\\n\\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\\n"}]',published:!0,mainMedia:{caption:"Highly Cited",originalUrl:"/media/original/117"}},components:[{type:"htmlEditorComponent",content:'IntechOpen is proud to announce that 191 of our authors have made the Clarivate™ Highly Cited Researchers List for 2020, ranking them among the top 1% most-cited.
\n\nThroughout the years, the list has named a total of 261 IntechOpen authors as Highly Cited. Of those researchers, 69 have been featured on the list multiple times.
\n\n\n\nReleased this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\n\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\n'}],latestNews:[{slug:"intechopen-supports-asapbio-s-new-initiative-publish-your-reviews-20220729",title:"IntechOpen Supports ASAPbio’s New Initiative Publish Your Reviews"},{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"}]},book:{item:{type:"book",id:"7701",leadTitle:null,fullTitle:"Assistive and Rehabilitation Engineering",title:"Assistive and Rehabilitation Engineering",subtitle:null,reviewType:"peer-reviewed",abstract:"Rehabilitation enables people with sensorimotor and cognitive disabilities to regain functions and autonomy. However, over the past few years, there has been a reduction in healthcare providers to assist patients. Fortunately, this decline has been accompanied by an increase in technological applications to support health systems. This new paradigm brings promising perspectives but raises questions regarding the therapy assisted by computers. To address these issues, this book intends to clarify the multidisciplinary aspects of medical engineering. The volume covers studies on the technical challenges in and barriers to the development of efficient rehabilitation and assistive technologies. It also provides a comprehensive approach to the recent advances in tele-health as a complementary medium to support the recovery process and to enhance patients' empowerment.",isbn:"978-1-78923-884-6",printIsbn:"978-1-78923-883-9",pdfIsbn:"978-1-78984-526-6",doi:"10.5772/intechopen.77514",price:119,priceEur:129,priceUsd:155,slug:"assistive-and-rehabilitation-engineering",numberOfPages:204,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"4191b744b8af3b17d9a80026dcb0617f",bookSignature:"Yves Rybarczyk",publishedDate:"December 4th 2019",coverURL:"https://cdn.intechopen.com/books/images_new/7701.jpg",numberOfDownloads:9094,numberOfWosCitations:5,numberOfCrossrefCitations:12,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:15,numberOfDimensionsCitationsByBook:0,hasAltmetrics:1,numberOfTotalCitations:32,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"September 4th 2018",dateEndSecondStepPublish:"October 16th 2018",dateEndThirdStepPublish:"December 15th 2018",dateEndFourthStepPublish:"March 5th 2019",dateEndFifthStepPublish:"May 4th 2019",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"72920",title:"Prof.",name:"Yves",middleName:"Philippe",surname:"Rybarczyk",slug:"yves-rybarczyk",fullName:"Yves Rybarczyk",profilePictureURL:"https://mts.intechopen.com/storage/users/72920/images/system/72920.jpeg",biography:"Yves Rybarczyk holds a Ph.D. in robotics from the University of Evry, France. His teaching and research activities focus on artificial intelligence and human-machine interaction. He was an Assistant Professor at the Nova University of Lisbon between 2007 and 2015. Then, he moved to South America where he held the position of Associate Professor and Head of the Intelligent & Interactive Systems Lab at the Universidad de Las Américas, until 2019. Currently, he is a Full Professor and Director of the doctoral program in microdata analysis at the Dalarna University, Sweden. He has participated in several projects on the modeling and development of complex and interactive systems. He is the author of over 100 scientific publications. Prof. Rybarczyk is a member of the steering committee of the International Summer Workshops on Multimodal Interfaces and an associate editor for both journals Frontiers in Computer Science and Frontiers in Psychology.",institutionString:"Dalarna University, Faculty of Data and Information Sciences",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"4",totalChapterViews:"0",totalEditedBooks:"2",institution:{name:"Dalarna University",institutionURL:null,country:{name:"Sweden"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"197",title:"Physical Medicine and Rehabilitation",slug:"physical-medicine-and-rehabilitation"}],chapters:[{id:"67341",title:"Introductory Chapter: Transdisciplinary Considerations on Assistive and Rehabilitation Systems",doi:"10.5772/intechopen.86590",slug:"introductory-chapter-transdisciplinary-considerations-on-assistive-and-rehabilitation-systems",totalDownloads:724,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Yves Rybarczyk",downloadPdfUrl:"/chapter/pdf-download/67341",previewPdfUrl:"/chapter/pdf-preview/67341",authors:[{id:"72920",title:"Prof.",name:"Yves",surname:"Rybarczyk",slug:"yves-rybarczyk",fullName:"Yves Rybarczyk"}],corrections:null},{id:"67536",title:"Toward a Design of a Telerehabilitation Program for the Functional Recovery in Post-Hip Arthroplasty Patients",doi:"10.5772/intechopen.85768",slug:"toward-a-design-of-a-telerehabilitation-program-for-the-functional-recovery-in-post-hip-arthroplasty",totalDownloads:991,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:1,abstract:"Telerehabilitation uses new information and communication technologies as an instrument to ensure a distant rehabilitation service. Patients who underwent hip replacement surgery are an excellent case study for the application of this technology. Post-surgical rehabilitation guidelines for hip arthroplasty are well known, and the correct application has a positive effect on the patients’ prognosis. However, there are no complementary guidelines for physical therapy that could be used at a distance by patients through a computer platform. This chapter presents a systematic review about conventional physical therapy programs for hip arthroplasty. Based on this review, we proposed therapeutic exercises adapted to a low cost web-platform. In order to reach this objective we will present a brief review of the total hip arthroplasty, telemedicine, telerehabilitation and conventional physical therapy approaches.",signatures:"Wilmer Esparza, Arian Ramón Aladro-Gonzalvo, Jonathan Baldeon and Sophia Ortiz",downloadPdfUrl:"/chapter/pdf-download/67536",previewPdfUrl:"/chapter/pdf-preview/67536",authors:[{id:"277707",title:"Ph.D.",name:"Wilmer",surname:"Esparza",slug:"wilmer-esparza",fullName:"Wilmer Esparza"},{id:"296218",title:"MSc.",name:"Arian Ramón",surname:"Aladro-Gonzalvo",slug:"arian-ramon-aladro-gonzalvo",fullName:"Arian Ramón Aladro-Gonzalvo"},{id:"296219",title:"BSc.",name:"Jonathan",surname:"Baldeon",slug:"jonathan-baldeon",fullName:"Jonathan Baldeon"},{id:"296220",title:"BSc.",name:"Sophia",surname:"Ortiz",slug:"sophia-ortiz",fullName:"Sophia Ortiz"}],corrections:null},{id:"66720",title:"A Systematic Review of Usability and Accessibility in Tele-Rehabilitation Systems",doi:"10.5772/intechopen.85869",slug:"a-systematic-review-of-usability-and-accessibility-in-tele-rehabilitation-systems",totalDownloads:1163,totalCrossrefCites:2,totalDimensionsCites:3,hasAltmetrics:1,abstract:"The appropriate development of tele-rehabilitation platforms requires the involvement and iterative assessments of potential users and experts in usability. Usability consists of measuring the degree to which an interactive system can be used by specified final users to achieve quantified objectives with effectiveness, efficiency, and satisfaction in a quantified context of use. Usability studies need to be complemented by an accessibility assessment. Accessibility indicates how easy it is for a person to access any content, regardless of their physical, educational, social, psychological, or cultural conditions. This chapter intends to conduct a systematic review of the literature on usability and accessibility in tele-rehabilitation platforms carried out through the PRISMA method. To do so, we searched in ACM, IEEE Xplore, Google Scholar, and Scopus databases for the most relevant papers of the last decade. The main result of the usability shows that the user experience predominates over the heuristic studies, and the usability questionnaire most used in user experience is the SUS. The main result of the accessibility reveals that the topic is only marginally studied. In addition, it is observed that Web applications do not apply the physical and cognitive accessibility standards defined by the WCAG 2.1.",signatures:"Jorge Luis Pérez Medina, Patricia Acosta-Vargas and Yves Rybarczyk",downloadPdfUrl:"/chapter/pdf-download/66720",previewPdfUrl:"/chapter/pdf-preview/66720",authors:[{id:"255870",title:"Dr.",name:"Yves",surname:"Rybarczyk",slug:"yves-rybarczyk",fullName:"Yves Rybarczyk"},{id:"275889",title:"Dr.",name:"Jorge Luis",surname:"Pérez Medina",slug:"jorge-luis-perez-medina",fullName:"Jorge Luis Pérez Medina"},{id:"275895",title:"MSc.",name:"Patricia",surname:"Acosta-Vargas",slug:"patricia-acosta-vargas",fullName:"Patricia Acosta-Vargas"}],corrections:null},{id:"69866",title:"Dual Loop Theory: Eidetic Feedback Control and Predictive Feedback Control",doi:"10.5772/intechopen.89681",slug:"dual-loop-theory-eidetic-feedback-control-and-predictive-feedback-control",totalDownloads:724,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"We have been studying on human information processing and finding out two types of feedback loop, positive and negative which are used when people understand a sentence. Former one is eidetic feedback control by visual sensory organs with encoding short-term memory (STM). Latter one is predictive feedback control by phonological imagery and schema, which help recall and reconstruction or reformation of concepts concerning with long term memory (LTM). Moreover, those strategies might be related to their behavior or attitudes. We have hypotheses that there are individual differences depending on strategies how two loops are used. Those findings must lead coordinating transformation and learning control for AI doctor or care assistive robots, which are required to interact with various types of people so that they can predict their behavior and attitudes through feedforward control.",signatures:"Keiko Tsujioka",downloadPdfUrl:"/chapter/pdf-download/69866",previewPdfUrl:"/chapter/pdf-preview/69866",authors:[{id:"276365",title:"M.A.",name:"Keiko",surname:"Tsujioka",slug:"keiko-tsujioka",fullName:"Keiko Tsujioka"}],corrections:null},{id:"65497",title:"Technical Contributions to the Quality of Telerehabilitation Platforms: Case Study—ePHoRt Project",doi:"10.5772/intechopen.83686",slug:"technical-contributions-to-the-quality-of-telerehabilitation-platforms-case-study-ephort-project",totalDownloads:977,totalCrossrefCites:4,totalDimensionsCites:4,hasAltmetrics:1,abstract:"This chapter proposes three main technical contributions for the development of a telerehabilitation platform, named ePHoRT, for patients recovering from hip surgery. The first contribution is the application of a diffuse 3D model for the detection of rehabilitation exercises after hip surgery. The model applies fuzzy logic, which allows identifying in real time if a patient is performing a right or wrong movement, assisted by an avatar in 3D. The avatar copies the movements of the patient through a Kinect camera. The second contribution involves the proposal of an iterative method to improve the usability of telerehabilitation platforms along the development life cycle. The proposed method involves the use of an inspection method and includes protocols and instruments. This method has been validated in the ePHoRT project. Finally, the chapter describes accessibility guidelines for educational resources. It proposes accessibility standards for the content of educational resources in video and PDF formats in the telerehabilitation platform according to the Web Content Accessibility Guidelines (WCAG).",signatures:"Patricia Acosta-Vargas, Janio Jadán-Guerrero, Cesar Guevara, Sandra Sanchez-Gordon and Tania Calle-Jimenez",downloadPdfUrl:"/chapter/pdf-download/65497",previewPdfUrl:"/chapter/pdf-preview/65497",authors:[{id:"275895",title:"MSc.",name:"Patricia",surname:"Acosta-Vargas",slug:"patricia-acosta-vargas",fullName:"Patricia Acosta-Vargas"},{id:"273592",title:"Dr.",name:"Sandra",surname:"Sanchez-Gordon",slug:"sandra-sanchez-gordon",fullName:"Sandra Sanchez-Gordon"},{id:"276197",title:"Dr.",name:"Tania",surname:"Calle-Jimenez",slug:"tania-calle-jimenez",fullName:"Tania Calle-Jimenez"},{id:"276198",title:"Dr.",name:"Janio",surname:"Jadán-Guerrero",slug:"janio-jadan-guerrero",fullName:"Janio Jadán-Guerrero"},{id:"276201",title:"Dr.",name:"César",surname:"Guevara",slug:"cesar-guevara",fullName:"César Guevara"}],corrections:null},{id:"66599",title:"MedBike: Virtual Reality for Remote Cardiac Rehabilitation",doi:"10.5772/intechopen.85651",slug:"medbike-virtual-reality-for-remote-cardiac-rehabilitation",totalDownloads:852,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Exercise-based cardiac rehabilitation (exCR) is a key element of a multi-disciplinary cardiac rehabilitation program towards the care of patients with acute or chronic cardiac disease. Many studies have shown that patient’s adherence to these programs is low despite evidence that such programs can improve outcomes and critical cardiac event reduction. New strategies to improve adherence to exCR programs are now being tested using non-hospital solutions that relies on VR gaming technologies. This paper presents such a system called MedBike which allows patients to perform an exCR program at home while being monitored in real-time by a remote clinician. The paper describes the technical aspects of the system, its pros and cons, various gamification strategies, and a recent usability study.",signatures:"Pierre Boulanger, William Mott, Stephanie Schaeffer, Peter W. Wood, Raj Padwal and Paolo Raggi",downloadPdfUrl:"/chapter/pdf-download/66599",previewPdfUrl:"/chapter/pdf-preview/66599",authors:[{id:"273326",title:"Dr.",name:"Pierre",surname:"Boulanger",slug:"pierre-boulanger",fullName:"Pierre Boulanger"},{id:"277755",title:"MSc.",name:"Peter",surname:"Wood",slug:"peter-wood",fullName:"Peter Wood"},{id:"277757",title:"Mr.",name:"Willam",surname:"Mott",slug:"willam-mott",fullName:"Willam Mott"},{id:"277758",title:"Ms.",name:"Stephanie",surname:"Schaeffer",slug:"stephanie-schaeffer",fullName:"Stephanie Schaeffer"},{id:"277760",title:"Dr.",name:"Raj",surname:"Padwal",slug:"raj-padwal",fullName:"Raj Padwal"},{id:"294278",title:"Dr.",name:"Paolo",surname:"Raggi",slug:"paolo-raggi",fullName:"Paolo Raggi"}],corrections:null},{id:"66909",title:"Restoring Independent Living after Disability Using a Wearable Device: A Synergistic Physio-Neuro Approach to Leverage Neuroplasticity",doi:"10.5772/intechopen.86011",slug:"restoring-independent-living-after-disability-using-a-wearable-device-a-synergistic-physio-neuro-app",totalDownloads:883,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The number of people living with various grades of disability is now in excess of 1 billion. A significant portion of this population is dependent on caregivers and unable to access or afford therapy. This emerging healthcare challenge coincides with new knowledge about the self-learning, self-organizing, neuroplastic nature of the brain, offering hope to those trying to regain independence after disability. As conditions such as stroke and dementia begin to affect more and more people in the younger age groups, there is an urgent, global need for a connected rehabilitation solution that leverages the advantages of neuroplasticity to restore cognitive and physical function. This chapter explains a novel approach using a Synergistic Physio-Neuro learning model (SynPhNe learning model), which mimics how babies learn. This learning model has been embedded into a wearable, biofeedback device that can be used to restore function after stroke, injury, the degenerative effects of aging or a childhood learning disability. This chapter enumerates the clinical studies conducted with adult stroke patients in two scenarios—with therapist supervision and with lay person supervision. The results indicate that such a learning model is effective and promises to be an accessible and affordable solution for patients striving for independence.",signatures:"Subhasis Banerji, John Heng, Effie Chew, Christopher Wee Keong Kuah, Ling Zhao, Soh Yan Ming, Daphne Menezes and Ponvignesh Ponnusamy",downloadPdfUrl:"/chapter/pdf-download/66909",previewPdfUrl:"/chapter/pdf-preview/66909",authors:[{id:"125587",title:"Dr.",name:"John",surname:"Heng",slug:"john-heng",fullName:"John Heng"},{id:"276071",title:"Ph.D.",name:"Subhasis",surname:"Banerji",slug:"subhasis-banerji",fullName:"Subhasis Banerji"},{id:"297500",title:"Dr.",name:"Effie",surname:"Chew",slug:"effie-chew",fullName:"Effie Chew"},{id:"297501",title:"M.Sc.",name:"Christopher Wee Keong",surname:"Kuah",slug:"christopher-wee-keong-kuah",fullName:"Christopher Wee Keong Kuah"},{id:"297502",title:"Ms.",name:"Zhao",surname:"Ling",slug:"zhao-ling",fullName:"Zhao Ling"},{id:"297503",title:"Ms.",name:"Yan Ming",surname:"Soh",slug:"yan-ming-soh",fullName:"Yan Ming Soh"},{id:"297504",title:"Dr.",name:"Daphne",surname:"Menezes",slug:"daphne-menezes",fullName:"Daphne Menezes"},{id:"297505",title:"Mr.",name:"Ponvignesh",surname:"Ponnusamy",slug:"ponvignesh-ponnusamy",fullName:"Ponvignesh Ponnusamy"}],corrections:null},{id:"65486",title:"An Embedded Gait Analysis System for CNS Injury Patients",doi:"10.5772/intechopen.83826",slug:"an-embedded-gait-analysis-system-for-cns-injury-patients",totalDownloads:922,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Clinical evaluation of CNS injury patients before and after treatment is an essential step in gait rehabilitation. Medical care of gait disturbance for stroke patients is based on different treatments based on clinical and functional evaluations. Evaluation of gait aims at characterizing the motor performance to provide clinicians with information on the patient’s organizational or performance status and to allow them to consider the most appropriate treatment options. A 3D instrumented gait analysis system allows quantification of several parameters at each instant of walking but does not represent gait in daily life conditions. The absence of devices usable in daily life situation constitutes a lack pointed out by clinical practitioners and is at the origin of this work. In the following are described the design and implementation of a wireless embedded system for the collection of spatiotemporal parameters of pathological gait in everyday life. Algorithms estimate joint angles, step length, and gait events and automatically partition data into gait cycles. Experiments have been carried out to accurately evaluate the joint angles, the precision of sensor synchronization, the precision of gait event detection, and the robustness in the case of pathological walk. Comparisons with references given by the 3D instrumented gait analysis system are detailed.",signatures:"Gilbert Pradel, Tong Li, Didier Pradon and Nicolas Roche",downloadPdfUrl:"/chapter/pdf-download/65486",previewPdfUrl:"/chapter/pdf-preview/65486",authors:[{id:"277504",title:"Associate Prof.",name:"Gilbert",surname:"Pradel",slug:"gilbert-pradel",fullName:"Gilbert Pradel"},{id:"277519",title:"Dr.",name:"Nicolas",surname:"Roche",slug:"nicolas-roche",fullName:"Nicolas Roche"},{id:"289383",title:"Dr.",name:"Tong",surname:"Li",slug:"tong-li",fullName:"Tong Li"},{id:"289384",title:"Dr.",name:"Didier",surname:"Pradon",slug:"didier-pradon",fullName:"Didier Pradon"}],corrections:null},{id:"66191",title:"Improvement of Cooperative Action for Multi-Agent System by Rewards Distribution",doi:"10.5772/intechopen.85109",slug:"improvement-of-cooperative-action-for-multi-agent-system-by-rewards-distribution",totalDownloads:774,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The frequency of natural disasters is increasing everywhere in the world, which is a major impediment to sustainable development. One important issue for the international community is to reduce vulnerability to and damage from disasters. In addition, a large number of injuries occur simultaneously in a large-scale disaster, and the condition of the injured will change over time. Efficient rescue activities are carried out using triage to determine the priority of injury treatment based on the severity of the persons’ conditions. In this chapter, we discuss acquiring cooperative behavior of rescuing the injured and clearing obstacles according to triage of the injured in a multi-agent system. We propose three methods of reward distribution: (1) reward distribution responding to the condition of the injured, (2) reward distribution based on the contribution degree, and (3) reward distribution by the contribution degree responding to the condition of the injured. We investigated the effectiveness of the three proposed methods for a disaster relief problem by an experiment. The results of the experiment showed that agents gained high rewards by rescuing those in most urgent need under the method having the reward distributed according to the contribution degree responding to the condition of the injured.",signatures:"Mengchun Xie",downloadPdfUrl:"/chapter/pdf-download/66191",previewPdfUrl:"/chapter/pdf-preview/66191",authors:[{id:"14248",title:"Prof.",name:"Mengchun",surname:"Xie",slug:"mengchun-xie",fullName:"Mengchun Xie"}],corrections:null},{id:"66160",title:"A Cooperative Game Using the P300 EEG-Based Brain-Computer Interface",doi:"10.5772/intechopen.84621",slug:"a-cooperative-game-using-the-p300-eeg-based-brain-computer-interface",totalDownloads:1094,totalCrossrefCites:6,totalDimensionsCites:8,hasAltmetrics:1,abstract:"In this paper, we present a cooperative game, Brainio Bros 300, using a brain-computer interface (BCI). The game is cooperatively controlled by two people using P300-generating color discrimination. The two users advance through the game together, one as the “player” and the other as the “supporter” providing assistance. We assumed that players would be able-bodied, while supporters would include people with severe disabilities. Through experiments using human subjects, we evaluated the subjects’ impressions of the game and its usefulness. The results of the impression evaluation showed that the subjects generally had good impressions, and there were many opinions that such cooperative games are interesting. We also discuss the possibilities of using the P300 BCI.",signatures:"Kaoru Sumi, Keigo Yabuki, Thomas James Tiam-Lee, Abdelkader Nasreddine Belkacem, Quentin Ferre, Shogo Hirai and Teruto Endo",downloadPdfUrl:"/chapter/pdf-download/66160",previewPdfUrl:"/chapter/pdf-preview/66160",authors:[{id:"281030",title:"Prof.",name:"Kaoru",surname:"Sumi",slug:"kaoru-sumi",fullName:"Kaoru Sumi"},{id:"290439",title:"Mr.",name:"Keigo",surname:"Yabuki",slug:"keigo-yabuki",fullName:"Keigo Yabuki"},{id:"290440",title:"Mr.",name:"Thomas James",surname:"Tiam-Lee",slug:"thomas-james-tiam-lee",fullName:"Thomas James Tiam-Lee"},{id:"290441",title:"Dr.",name:"Abdelkader Nasreddine",surname:"Belkacem",slug:"abdelkader-nasreddine-belkacem",fullName:"Abdelkader Nasreddine Belkacem"},{id:"290442",title:"Mr.",name:"Quentin",surname:"Ferre",slug:"quentin-ferre",fullName:"Quentin Ferre"},{id:"290443",title:"Mr.",name:"Shogo",surname:"Hirai",slug:"shogo-hirai",fullName:"Shogo Hirai"},{id:"290444",title:"Mr.",name:"Teruto",surname:"Endo",slug:"teruto-endo",fullName:"Teruto Endo"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"7796",title:"Human 4.0",subtitle:"From Biology to Cybernetic",isOpenForSubmission:!1,hash:"5ac5c052d3a593d5c4f4df66d005e5af",slug:"human-4-0-from-biology-to-cybernetic",bookSignature:"Yves Rybarczyk",coverURL:"https://cdn.intechopen.com/books/images_new/7796.jpg",editedByType:"Edited by",editors:[{id:"72920",title:"Prof.",name:"Yves",surname:"Rybarczyk",slug:"yves-rybarczyk",fullName:"Yves Rybarczyk"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10192",title:"Background and Management of Muscular Atrophy",subtitle:null,isOpenForSubmission:!1,hash:"eca24028d89912b5efea56e179dff089",slug:"background-and-management-of-muscular-atrophy",bookSignature:"Julianna Cseri",coverURL:"https://cdn.intechopen.com/books/images_new/10192.jpg",editedByType:"Edited by",editors:[{id:"135579",title:"Dr.",name:"Julianna",surname:"Cseri",slug:"julianna-cseri",fullName:"Julianna Cseri"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8335",title:"Effective Prevention and Treatment of Substance Use Disorders for Racial and Ethnic Minorities",subtitle:null,isOpenForSubmission:!1,hash:"ca6c7d5d975b1fa9ce320b1162b0dad6",slug:"effective-prevention-and-treatment-of-substance-use-disorders-for-racial-and-ethnic-minorities",bookSignature:"Erick Guerrero and Tenie Khachikian",coverURL:"https://cdn.intechopen.com/books/images_new/8335.jpg",editedByType:"Edited by",editors:[{id:"294761",title:"Dr.",name:"Erick",surname:"Guerrero",slug:"erick-guerrero",fullName:"Erick Guerrero"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7178",title:"Prosthesis",subtitle:null,isOpenForSubmission:!1,hash:"87ab135eeaa8424520cff806439e32a2",slug:"prosthesis",bookSignature:"Ramana Vinjamuri",coverURL:"https://cdn.intechopen.com/books/images_new/7178.jpg",editedByType:"Edited by",editors:[{id:"196746",title:"Dr.",name:"Ramana",surname:"Vinjamuri",slug:"ramana-vinjamuri",fullName:"Ramana Vinjamuri"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10615",title:"Contemporary Advances in Sports Science",subtitle:null,isOpenForSubmission:!1,hash:"725573ecd45f3f984f173d7d6dba0433",slug:"contemporary-advances-in-sports-science",bookSignature:"Redha Taiar",coverURL:"https://cdn.intechopen.com/books/images_new/10615.jpg",editedByType:"Edited by",editors:[{id:"81693",title:"Prof.",name:"Redha",surname:"Taiar",slug:"redha-taiar",fullName:"Redha Taiar"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9153",title:"Sports, Health and Exercise Medicine",subtitle:null,isOpenForSubmission:!1,hash:"366cfd9d5b01961dff4e4172896b1955",slug:"sports-health-and-exercise-medicine",bookSignature:"Samuel Honório, Marco Batista, João Serrano and Maria-Raquel G. 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The intended purpose of the book will be to extend the circle of users of the Kalman filter by considering it not as a means of theoretical analysis, but rather as a powerful tool for the design of a technical system. The editor accumulated experience of using suboptimal KF in various aerospace applications and would wish to share it with the pool of potential users and like-minded specialists. Instead of the formal programming of the recursive KF equations some simple and robust sub-optimal forms are proposed. For example, developed by the editor, suboptimal (KBF), with bounded grows of memory (FBGM) and its steady-state form- the time-invariant filter with constant coefficients is aimed to be considered. This allows the developer to use the KBF not only for system state estimation but for control as well. Proceeding in this way developer can be guaranteed the filter stability and robustness in many practically uncertain situations when the statistic characteristics of system disturbances and measured errors are not entirely known. A guaranteed approach with using an equivalent white noise is also aimed to be considered. Some representative examples from typical aerospace systems (the editor’s main professional field) are intended to be presented. Summarizing the above, it can be emphasized that when implementing the KF it is always useful to replace the art of programming with the experience of designing conventional robust systems having an idealistic estimate of maximum (best) of achievable performance. This would prevent the system's real-time computer from many possible situations with “empty “computations and even to the divergence of the computational process. It can also show that the filter is not a magic mill and cannot achieve the desired performance if it cannot be achieved in principle, better that it can be “promised” by the KF quadratic criterion minimum, or if some state vector components are not observable and controllable.
",isbn:"978-1-80356-576-7",printIsbn:"978-1-80356-575-0",pdfIsbn:"978-1-80356-577-4",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!1,isSalesforceBook:!1,isNomenclature:!1,hash:"4c3e68adcaeaa44f9fbfe9bb19bdd55b",bookSignature:"Dr. Yuri Kim",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11504.jpg",keywords:"Separation Theorem, Extended Kalman Filter, Covariance Matrix, Riccati Equation, FBGM, Analytical Implementation Forms, Physical Implementation Forms, Steady State Filter, Inertial Navigation System, Global Positioning System, Controllability, Multisensory Navigation",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"March 15th 2022",dateEndSecondStepPublish:"June 2nd 2022",dateEndThirdStepPublish:"August 1st 2022",dateEndFourthStepPublish:"October 20th 2022",dateEndFifthStepPublish:"December 19th 2022",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"3 months",secondStepPassed:!0,areRegistrationsClosed:!0,currentStepOfPublishingProcess:4,editedByType:null,kuFlag:!1,biosketch:"Prof. Y.V. Kim is a Doctor of Technical Science, having a broad and wealthy international scientific, engineering, and teaching experience, obtained in the former USSR, Israel, and Canada. He has many scientific publications and implemented inventions dedicated to Aerospace GN&C.",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"316140",title:"Dr.",name:"Yuri",middleName:null,surname:"Kim",slug:"yuri-kim",fullName:"Yuri Kim",profilePictureURL:"https://mts.intechopen.com/storage/users/316140/images/system/316140.jpg",biography:"Yuri Kim\n24 Buttenut, Gatineau, QC, Canada\nTel : 1-(514)- 466-1033, e-mail: yurikim@hotmail.ca\n\nHIGHLIGHTS OF QUALIFICATIONS:\n\nExperienced scientist, engineer and manager with internationally recognized achievements in area of Aerospace Avionics, (GN&C); Analysis, design (HW&SW), integration, testing and operation for various aerospace platforms and missions. \n\nGained a broad experience in preparation of technical documents for Joint (Industry-Customer) State Commissions for the acceptance (commissioning) of Aerospace Avionics, Navigation and Special application experimental equipment for further serial production, and operational support. Last works have been dedicated to R&D projects developing new Satellite Navigation Control Technology and customer support of Canadian satellites Control system design.\n\n\nACADEMIC DEGREES:\n\n 1991 *Doctor of Technical Science Diploma in Aerospace Vehicles Guidance \n Navigation and Control \n Scientific Council of State Institute of Automatic Systems, Ministry of Aviation\n Industry of USSR, Moscow\n (Recognized by Canadian Professional Counsel of Engineers) \n1982 * Senior Scientific Fellow Diploma in Gyroscopes and Navigation systems \n Capital Certification Commission of Scientists, Ministry of High Education of\n USSR, Moscow.\n (Recognized by Canadian Professional Counsel of Engineers)\n1974 * Candidate of Technical Science Diploma in Aerospace Navigation\n and Control Systems (Accredited as Ph.D by York University, Toronto.)\n Scientific Council of Moscow Aviation Institute, Moscow.\n1970 * Engineer Electromechanic Diploma in Gyro and Navigation systems,\n Faculty of Flight Apparatuses Control Systems, Moscow Aviation Institute, \n Moscow (Accredited as between Masters Degree and Bachelor Degree by\n York University, Toronto).\n1965 * Radio and TV Systems Technician Certificate, Dnepropetrovsk Technical School \n of preparation of technical specialists for Soviet Army, Military Aviation and \n Navy.\n\nMILITARY EDUCATION:\n\n1970 * Engineer in ballistic rocket control system, Military Faculty of MAI, last rank senior engineer-lieutenant (in reserve)\n\n\n\nEMPLOYMENT HISTORY:\nA. GOVERNMENT\n\nAt present - Canadian Space Agency, Space Science and Technology Division, David Florida Laboratory\n\n Senior Aerospace System engineer \n\n° Performing, developing and supporting phases of design, testing, commissioning and \n operation for space vehicle orbit and attitude control systems, in particular: Tecsas, Scope, \n J2Sat, Small satellite, M3Msat, Cassiopea, Neossat, RCM, PCW\n\n° Reviewing and commenting on Attitude Control systems design documentations, related to \n all phases of system development commissioning and operation\n \n° Supporting Aerospace Industry R&D projects funding by CSA (STDP) as Scientific\n Authority, in particular: Microwheel (Dynacon), LOCOOS (NGC), PCW (Bristol)\n\n° Providing expertise on new initiatives for Space Exploration and Utilization regarding \n Attitude and Orbital Control and possible development of Canadian space launcher\n\n° Developing basic mathematical (Simulink/Matlab) simulator for developing the \n requirements and expected performance of AODCS for new space vehicles\n\n° Developing new basic technology (based on Kalman Filter) for satellite attitude\n determination and sensor calibration, developing of FF test-bed equipment and GPS \n navigation in environment of CSA laboratory, developing of methods of ACS sensors\n calibration, measuring and compensation of satellite residual magnetic moment, experimental determination of satellite inertia matrix during ACS integration tests\n\n° Interacting with Space Industry and Universities in the problems, related to development of \n new methods and systems for space vehicle attitude and orbit determination and control\n \n° Sharing with International Aerospace community CSA achievements and experience in\n development of new technologies and methods for space vehicle attitude and orbit \n determination and control through publications, presentations and participation in scientific\n conferences, meetings and symposiums as well as maintaining an awareness about new \n technological advancements\n \n° Providing professional training for students and post. Graduates in the area of Orbital and\n Attitude Dynamic and Control\n\nB. INDUSTRIAL\n\nSept. 1998 – Feb. 1999 – Olympia Engineering Ltd. (Toronto)\n\nResearch and Development Engineer\n\n•\tDevelopment of measuring instrument for measuring remote measuring of micro- deformations of machinery (milling machine) equipment\n•\tResearch and testing of differential GPS survey equipment and antennas in environment of industrial facility for developing a new remote method for the measuring of machinery micro-deformations\n\n\n\n\nFeb.1999 – Jun.2002 – Saskatoon Engineering Division of Calian Company, \n Radarsat-1 Operation Team (CSA, Montreal)\n\nAttitude Control System Analyst\n\n•\tWorking as RADARSAT-1 Attitude Control System Analyst performing day-to-day operation TLM data analysis; reporting, monitoring and solving ACS flight anomaly problems, maintaining ACS software and performance \n•\tAuthor of many reports (see attached list of publications), devoted to solving of Radarsat-1 non-benign Safe Hold Mode problem, Momentum Wheel failure problems and improvement of the performance of attitude determination method with Magnetometer and Sun Sensor (back up, ADM3 mode for the case of potential failure of Horizon Scanner).\n•\tPreparation and implementation of the solution for RADARSAT-1 operation without failed Momentum Wheels, that saved the satellite mission after the wheel failures\n(This work was prolonged after in CSA and awarded by the Canadian Government Award for the invention used by the Government)\n•\tDesign and implementation of new dynamic simulators (based on Simulink\ntoolbox) for Radarsat-1 ACS for operation support\n•\tPreparation for operation of new Canadian satellites Scisat and RADARSAT-2 \n\n\n\nJan. 1994 – Sep. 1997 – Israel Aviation Industry (IAI factories: TASHAN, LAHAV)\n\nAvionics system engineer\n\n•\tResearch and preliminary design of the Special Data Fusion System for a fighter-interceptor\n•\tIntegration of Inertial Navigation System with Global Position System into Upgraded Avionics Suit and installation in aircraft cockpit for A/C – trainer T-38\n\nNov. 1977 – Apr. 1993 – Moscow Research and Design Institute of Electromechanic and Automatic (formerly P/B: M5537, presently “Aviapribor” Corporation)\n\n \nHead of Division (R&D in Pilot-Navigation Systems)\n\n•\tLeadership of the Division, performing planning, financial and methodological duties, related to this position, reporting to the R&D deputy director of the Institute\n•\tResponsibility for Pilot-Navigation System integration, interaction, tests and transferring for serial production and operational support\n•\tInitiation and methodical leadership of innovative research and development projects\n•\tReviewing, commenting and implementation of Technical standards and Navigation norms\nas well as sharing progressive methods and results within Aerospace organizations within former USSR\n \n Head of Department (INS and Flight Management System SW Development)\n\n•\tLeadership and performing of duties of Head of Department \n•\tResponsibility for the prospective research and preliminary design of the Inertial Navigation Systems (INS) and Flight Management Systems (FMS)\n•\tDesign of the INS and FMS algorithms and simulation of expected performance\n•\tDevelopment of INS/FMS flight code\n•\tDevelopment of test procedures and simulators for FMS, and pilot nav.complexis for aircrafts \n•\tResponsibility for system performance analysis in the ground and flight tests\n\n Head of Sector (System Flight Test data analysis) \n\n•\tLeadership of the Sector\n•\tDevelopment of ground and flight test simulation procedures and requirements for test equipment and simulators, for flight test aircraft measuring equipment, installation and recorded data processing\n•\tDesign of Estimation and Identification algorithms for ground and flight data processing\n•\tTest data analysis, preparation of test results analysis reports and conclusions\n\n Senior Scientific Fellow\n\n•\tResearch, development and principal design of the special Suboptimal Kalman Filter for the fusion of data of various navigation sensors for aviation and space platforms\n•\tDevelopment of new Guidance and Navigation methods for aviation and space platforms\n•\tAnalysis of INS and FMS performance in ground and flight tests\n\nC. ACADEMIC \n\n1977–1993 – Moscow Aviation Institute, Moscow Institute of Instrument -\n Making, Aviation Industry Ministry Upgrade Qualification Institute\n(Part Time) Professor, Associate professor, Chairmen of State Diploma Commission,\n Member of Scientific Council\n•\tLecturer of the disciplines: Applied Oscillation, Theory (MIIM), Design of Instruments (MIIM), Integrated Navigation Systems (MUQI)\n•\tChairman of the State Diploma Commission -Gyro Instruments and Systems (MAI)\n•\tLeadership of postgraduates, participation in sessions of Scientific Council (MAI)\n•\tMethodical management of cathedra of Orientation and Navigation in MAI \n\n2009 McGill University, Montreal\n\nPart time lecturer for course (in English): Aircraft Performance, Stability and Control\n\n1970–1977 – Moscow Aviation Institute \n(Full Time) Associate Professor, Senior Researcher, Assistant Lecturer \n•\tLecturer of the courses: Spacecraft orbital mechanics and attitude determination and control, Inertial Navigation Systems, Gyro Instruments and Systems\n•\tResearch and development of suboptimal robust estimation methods for navigation data processing\n•\tResponsibility for the navigation systems laboratory\n•\tDeputy head of cathedra of Orientation and Navigation\n\nFIELDS OF THEORETICAL AND METHODOLOGIC EXPERTISE:\n \n•\tSpace vehicle Orbit and Attitude determination and control\n•\tGyro instruments and systems\n•\tRadio navigation systems\n•\tInertial Navigation systems\n•\tAirplane Navigation and Control\n•\tAnalytical mechanics \n•\tApplied oscillation theory\n•\tAutomatic control theory\n•\tStochastic estimation theory\n\nENGINEERING EXPERIENCE:\n\n•\tFlight and laboratory tests of Aerospace Avionics Equipment\n•\tDistribution of mission requirements between Aerospace vehicle subsystems, definition of functions and ICD \n•\tSpacecraft operation and performance maintenance\n•\tAvionics system (hardware and software) development and testing (autonomously and integration)\n•\tInertial navigation systems\n•\t Development of Avionics for Soviet Military aircrafts: Tu-142, Tu-95MC, An-124, An-70, A-40, Soviet Space shuttle “Buran” (responsibility for preliminary design of radio-navigation automatic landing system), \n•\tIsrael (IAI) upgrade of Avionics system for T-38 (USA Air force trainer) \n•\tOperation and modification in space Canadian Satellite RADARSAT-1 Attitude Control system\n•\tParticipation in commissioning of ACS of Canadian Satellite Scisat\n•\tDevelopment of a generic mathematical simulator for satellite AODCS analysis and simulation of expected performance for a family of Canadian new generation small satellites\n\nSCIENTIFIC EXPERIENCE:\n\n•\tTheoretical and experimental investigation in the fields of S/C Orbital and Attitude Control\n•\tKalman Filter suboptimization and robust guarantee estimation theory development: authorship of new Suboptimal Kalman Filter modification, methods of INS correction and calibration, Geomagnetic Inertial Navigation System\n•\tResearch in areas of ACS and INS sensors development, their performance improvement\n•\tVarious Avionics Systems Mathematical models development and mathematical and semi-natural simulation\n•\tCoordination of research and development projects related to Aerospace equipment performed by Universities and Industries\n•\tScientific reports and articles reviewing and editorship \n•\tMembership in Scientific Counsels and Commissions\n•\tTutorship of under-graduate, graduated and post -graduate students \n\n•\tScientific reports and inventions in the field of GN&C for aircraft and spacecraft methods development \n•\tSeveral articles dedicated to the development of new methods in estimation theory: new suboptimal Kalman Filter with limited growth of the memory, observability and factor of state vector components estimation, guaranteed ellipsoidal estimation and stochastic estimation comparison \n\nLANGUAGES:\n \n•\tEnglish, Russian, Ukrainian, Hebrew, French (beginning level)\n•\tProgramming languages: Matlab/Simulinc/С",institutionString:"Canadian Space Agency",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"2",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"Canadian Space Agency",institutionURL:null,country:{name:"Canada"}}}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"15",title:"Mathematics",slug:"mathematics"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"453623",firstName:"Silvia",lastName:"Sabo",middleName:null,title:"Mrs.",imageUrl:"https://mts.intechopen.com/storage/users/453623/images/20396_n.jpg",email:"silvia@intechopen.com",biography:null}},relatedBooks:[{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and 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Above all, the optical fiber network was the main artery which supported a communications infrastructure, and various technology developments have been performed to take in traffic to increase rapidly [Cochennec 2002][ITU-T 2001][ ITU-T 2011]. On the other hand, wireless communication technology is essential element technology to realize ubiquitous communication environment. And new generation service development by new technology is beginning in the fields of mobile communication and broadcast [Lee 2007]. In addition, the research and development of ultra-high speed photonic network [Ben 2006][Zhang 2005][Kitayama 2005] performing the information transmission from the edge of the network to the edge in an optical domain is pushed forward, but an application of the radio technology to raise the flexibility in photonic network is an important problem, and advancement of optical wireless technology having possibility is expected [Kim 1999][Bouchet 1999]. However, it becomes further ultra-high speed/huge-capacity of the optical wireless and wavelength division multiplexing (WDM) limitation factor of the flexibility corresponding to various transmission methods because the current optical wireless system performs from optical to electrical (O/E) conversion of a transmitting and receiving part respectively. Therefore the realization of the optical wireless method that is not dependent on in ultra-high speed/huge-capacity and the interface (a protocol) of the device is enabled more than before if we can connect optical fiber to optical wireless as optical signal without performing O/E conversion, and it is expected that it can be it with the effective means of flexible photonic network construction. It is anticipated that compact optical antennas with an advanced fine optical tracking system will be used for the ultra-fast free space optical communication system in the next generation. Such laser communication systems will be used not only for the space communications [Kaliski 1999][Borocom 2005][Koyama 2004] but also the terrestrial long-distance photonic network. In this paper, we discuss demand specifications of optical antennas considering phenomena such as the scintillation which occurs by atmospheric turbulence. And then we explain optics design and the design results to satisfy demand specifications. We also mention the fine tracking mechanism using the fine pointing mirror (FPM) and the feedback of the signal’s incident angle detection by the quadrant detector (QD) for the antenna. The influences of fluctuation of laser beam angle-of-arrival (AOA) are reduced effectively. We mention the following research studies of the two optical wireless communication systems such as next generation free-space optical communication (NG-FSO) system and radio on FSO (RoFSO) system.
The various concepts and architectures of Free Space Optical Communication (FSO) systems are illustrated in Figure 1. Figure 1(a) shows a conventional FSO system [Infrared][ Free-Space]. Since it uses as a transmission media the difference wavelength as an optical fiber, it includes optical and electrical conversion between an optical fiber side and the free-space side. Furthermore, it is necessary to prepare a different interface which performs individual modulation and demodulation, coding, etc. for every communications service. Figure 1(b) shows the concept of a NG-FSO system [Takahashi 2008][Matsumoto 2008][Kazaura 2007]. In seamless connection of free-space and fiber systems an optical beam is emitted directly from a single mode fiber (SMF) termination to free-space using a new concept FSO antenna. Loss of the optical signal power caused by space transmission can be compensated using a fiber amplifier using the same wavelength band of 1550 nm as an optical fiber network [Khaleghi 1996][ Luo 1998]. In this method the need to convert the optical signal from electrical to optical formats or vice versa for transmitting or receiving through space is eliminated. Figure 1(c) shows the concept of a Radio on Free Space Optical communication (RoFSO) system for realizing application in radio service combining with Radio on Fiber (RoF) technology [Al-Raweshidy 2002][ Hai 2006]. Main advantage and goal of RoFSO systems is they can be used to quickly and effectively provide heterogeneous wireless service [Komaki 2003][Tsukamoto 2006] for example WiFi (IEEE 802.11),WiMAX (IEEE 802.16), cellular based 3G signals etc, simultaneously.
However, the challenge in NG-FSO system design is making seamless connection of free space propagated beam to the SMF. The optical signal which has been propagated through free-space is reduced by the optical elements like lens etc. in the antenna and focused to the core of SMF. The optical beam transmitted through the free-space is influenced by various weather conditions, such as attenuation by rain, fog, snow etc., and by atmospheric absorption. Furthermore, the beam experiences atmospheric turbulence as it propagates through free-space, as well as vibrations of the device at the installation site and beam distortion occurrence. The consequence of these effects is the fluctuation of the beam AOA which in turn leads to significant variation in the power of the light focused into the SMF. Although AOA is not a problem for conventional FSO system thanks to a large area of the photo detector, it is a problem for NG-FSO because of little margin between the arrival beam and SMF. It is therefore difficult to maintain a stable link performance.
The concept of various FSO systems, (a) conventional, (b) NG-FSO and (c) RoFSO
When laser beam propagates in the atmosphere [Tatarskii 1971][Dayton 1992][ Hufnagel 1974][Friend 1967][Andrew 1998], its phase is fluctuated by the scatter of cloud, fog and rain, also by the change of local refractive index of the atmosphere. The fluctuation is varied depending on medium, and it becomes the largest when its size is similar to the size of light, also the medium constant changes spatially and temporally at random. When refractive index slowly and continuously changes due to atmospheric turbulence, the forward scattering dominates because the scale of fluctuation is larger than the wave length. In this case, it is possible to ignore the fluctuation of plane of polarization, but the fluctuation of phase/angle of arrival and the amplitude and the scintillation should be taken into consideration. On the other hand, when the medium is distributed discretely such as cloud, fog and rain and so on, the refractive index changes drastically. Therefore, the equivalent damping which occurs due to absorbing/scattering of particles and the influence against polarization property by multiple scattering with multiple particles should be considered. Modified von Karman spectrum density function is used not to overflow an integral value in theoretical analyses [Andrew 1995]:
Herein,
Herein,
Therefore, the anticipated value of the received beam profile still remains Gaussian distribution, and the variant is given by the effective beam radius as follows:
And,
are the parameters which represents the influence of fluctuation,
Herein:
On the other hand, regarding the downlink, the following values are substituted into the equation (3).
With the above-mentioned formulas, we will discuss in the next section with the demand of optical specifications of the optical antenna available for NG-FSO system and RoFSO system.
The challenge in all-optical connection of FSO and SMF systems is not only to design an effective beam tracking and optical antenna alignment technique, but also an efficient method for focusing the light into the SMF at the receiver. Active tracking is required to maintain alignment of the received optical signal to the SMF. To achieve stable beam spot position control as well as compensate for beam AOA fluctuation caused by atmospheric turbulence we adopted a small size two axis galvanometer type mirror drive mechanism. This mirror device called fine pointing mirror (FPM) is shown in figure 2. The tracking system constitutes the feedback system which considers the direction of the optic axis of a received optical system which changes the arrival directions of beacon light with an input and inclination of FPM as an output. Figure 3 shows a block diagram of a tracking servo system. Although the actual servo system consists of two horizontal independent axes this figure shows only one axis. The position of the received beam is determined by calculation the position of the beacon spot on the four elements of the QD. This signal serves as an input of an analog proportional–integral–derivative (PID) controller. The transfer characteristic of FPM is carrying out the response of a typical secondary system (azimuth (Az) axis is 100 Hz and elevation (El) axis of resonance frequency is 80 Hz at the weak oscillating system of dumping), and the PID controller by progress and delay compensation is designed so that a control zone may become the largest in consideration of this characteristic and the nonlinearity of a tracking sensor. As a result, the control zone of the closed loop response has attained the performance of about 2 kHz. In the case of a feedback system, disturbance suppression performance is proportional to a closed loop zone. Therefore, this tracking system shows that tracking control more highly efficient a single figure than the conventional tracking system which was an about 100 Hz control zone was realizable. Disturbance is poured in from the integration input of Figure 4, and the result of having measured the tracking response which appears in a mirror drive output about Az axis is shown in Figure 5. A vertical axis is the amount of suppression of disturbance amplitude. The characteristic is the same also about El axis. On the frequency of 100 Hz or less, it turns out that it has the capability that disturbance can be suppressed or less to 1/100.
Photograph of FPM
Block diagram of the fine tracking servo system
Frequency characteristics of closed loop feedback system. (a) Amplitude (b) Phase
Turbulence suppression characteristics of feedback system
In research and development of the NG-FSO system, we developed a compact optical antenna suitable for optical communication between satellite in space and deployment in stratospheric platform [Arimoto 2003][Katsuo 2005]. Because of the limitation in payload and equipment size in such usage, a lightweight optical antenna was required designed using off-axis free-form optics without the obscuration [Takahashi 2006]. In general, a Galileo type optical system, composed of a convex lens and a concave lens, is used to convert input/output diameter of laser beam in an optical antenna. However, when using such kind of refractive optical system it is difficult to suppress reflection of each surface of lenses in a wide wavelength range, so measurement errors as a result of ghost and/or flare can arise. In addition, since this system is accompanied with a chromatic aberration, adjustment of the focal length based on a wavelength is necessary. Therefore, a reflection based optical system which does not have a chromatic aberration is suitable for an optical system that is incorporated into a highly precise optical antenna. Although there are many cases that a Cassegrain type configuration is used for beam expander of reflecting mirror system, it is not suitable for the optics of the antenna of this purpose because of an obscuration in the beam center caused by secondary mirror. We abandoned the constitution on co-axial optical system and devised off-axial reflection optical system instead. In case of optical wireless communication on ground or between ground and space, the fluctuation of arrival beam angle is caused by the atmospheric turbulence. Therefore, if comatic aberration of the optical antenna is large, beam expander causes peculiar aberrations according to an incident angle of laser beam. Because rotational asymmetric aberration (shown in Figure 6(b)) by the decentering of the optical element occurs as well as radial aberration such as the comatic aberration, in the case of an off-axial optical system, all those aberration becomes able to be compensated by using free-form surface for all mirrors. The free-form surface [Takahashi 2011] is curved surface defined in XY polynomial such as equation 13.
In one aspect, free-form surface becomes able to have positive and negative power (Figure 6(a)). Furthermore, the curvature of the tangential direction can be different from azimuth direction.
A free-form surface and Asymmetrical aberrations
The average expansion and fluctuation of light intensity of the laser beam at 1.550 μm wavelength with the atmospheric turbulence are calculated by using the expressions of Section 3 stated above. In this calculation, the transmission beam is Gaussian beam which have beam divergence of diffractive limit, the difference in altitude between the two stations (low altitude stratospheric platform experiment [Katsuo 2005] condition) is 4 km, zenith angle is 60 degree, the transmission distance of the beam is 8 km maximum, and the pointing errors is 0 μradian. When the transmission beam radius is 40 mm, the free space loss is approximately 1 dB. So that if the optical antenna achieves an output transmission of around 100 mW and the receiver sensitivity of -20 dB, we can expect a margin of 40 dB and it is possible to communicate under thin cloud or fog conditions. The relation between the beam radius at the transmitter (W0) and the average beam expansion at receiver point is shown in Figure 7. The mean intensity fluctuation of the received beam under similar conditions is shown in Figure 8. According to these results, the radius of received beam is varied slightly and the expansion rate of the radius of received beam is constant when the radius of transmit beam is more than 60 mm. Moreover, the larger the transmission beam diameter is, the smaller the amount of the decrease of center strength of the received beam, and the free space transmission loss is less than 5 dB for a transmit beam diameter of uplink 70 mm or downlink 50 mm or more. Assuming Cn2 is 1.7×10-14 (H/V model), we calculated the fluctuation of the received light intensity (scintillation index) by varying the transmitted beam radius. The result is shown in figure 9.
The change is small in weak fluctuation case and there is no big received optical power changes for propagation distance of ~4 km with laser beam transmit and receive aperture diameter of 10~100 mm therefore an optical antenna having this range of aperture beam transmission is possible. Because this fluctuation is significantly small and in the region of weak fluctuation and there is not large fluctuation of intensity of the received beam, the optical antenna which has such diameter of aperture transmits the optical beam have the possibility. The calculation result of receive light intensity fluctuation when the transmit beam radius is set at 20 mm and pointing error is 1 μradian are shown in figure 10. On the assumption that the inoperable rate is 10-7, it is necessary to consider the fading margins which are 3.6 dB for the uplink and 5.3 dB for the downlink. From these calculations, it is desirable for the pointing error to be around 1 μradian in consideration of fading when a diffraction limited Gaussian beam is transmitted.
The pointing error of the FPM used for the fine tracking of the NG-FSO system in this research is estimated to be approximately 20 μradian. The angular magnification of the optical antenna is 20, and the tracking accuracy in the system can expect the improvement of the atmosphere fluctuation to become 1.0 μradian in a calculation. Considering the above outlined analytical results, the target specifications of the optical system are as follows:
Optical antenna aperture diameter is 40 mm
Angular magnification is 20
Coupling efficiency with SMF on axis is around -1 dB
Resolution is diffraction limit of field angle ±0.2 degrees (less than wave aberration λ/10)
Rx beam radius versus Tx beam radius
Mean intensity depend on Tx beam radius
Scintillation index depend on Tx beam radius
Probability of fading level
In order to conduct an optical system without obscuration, having less deterioration of wavefront accuracy when the incident beam angle varies, we designed an optimum optical system comprising off-axial free form surface triple mirror which have enlargement/reduction rate of 20 times. Optical layout of triple mirror is shown in figure 7. Fundamental power placement in an optical design is a primary concave mirror plus a secondary convex mirror. With this optical configuration, a primary image is formed whose spherical and coma aberrations are compensated, and by using a collimator mirror which is arranged after the primary image a beam of parallel rays of light is producing. We set the paraxial focal length of the primary mirror and the secondary mirror at f1=230 mm, the collimator mirror at f2=11.8 mm, and the angular magnification of the triple mirror at approximately 20. Moreover, we have decentered aberrations, such as axial comatic aberration and axial astigmatism caused by tilt and decentered of both reflective surfaces, compensated by the three pieces of free-form mirror. A figure of constitution of the prototype of the optical antenna module which had a QD feedback type built-in fine tracking system by a microminiaturized fine pointing mirror (FPM) is shown in figure 11, the photograph is shown in figure 12, and the photograph is shown in figure 13. Based on the design result, the calculations of coupling efficiency when an ideal lens is deployed in the radiation side are shown in figure 14.
Optical layout of an optical antenna with off-axial free form optics.
Appearance of prototype of optical antenna module
Photograph of prototype optical antenna on the gimbal stage
Coupling efficiency depend on internal field of view
The test beds were put on two campuses of the Waseda University campus area situated in Shinjuku Ward, Tokyo city [Kazaura 2007][Kazaura 2006]. Figure 11 shows a map view of where the FSO systems are deployed. Two antennas were set on the rooftop of a 10 floor building (figure 15) and the corresponding antennas on the rooftop of a 9 floor building with a link spanning 1 km between the transceivers on the top of those two buildings. The antenna shown on the right in figure 16 is the antenna under experiment while the antenna on the left is used for scintillation and optical power attenuation measurement. They are both connected to data acquisition system placed in the experiment setup room which records all the data as shown in figure 17. The FSO beam propagation path travels over low rising residential, office or campus buildings, thus transmitted beam will experience higher probability of scintillation from ground heating and heating from these buildings. The experimental antennas use a 980 nm beacon for alignment and 1550 nm wavelength for communication. A charge coupled device (CCD) camera is used for initial alignment purposes which is done manually adjusting thimble screws located at the base of the antenna. Repeated adjustments are made on both sides until the light is centered on both CCD cameras (see TV monitor in figure16). Fine alignment of the antennas is achieved by using a QD which gets a feedback of the maximum received power from the inbuilt data acquisition system. The 1550 nm transmission beam was driven by an erbium doped fiber amplifier (EDFA) capable of outputting 100 mW total power. The experimental antenna can be controlled from a remote location by a serial computer interface to send control information that is used for remote alignment. For the scintillation and optical power attenuation measurement antennas, a serial computer interface provides the beam output power and receives signal strength information and other information.
The basic configuration of our experimental setup for the developed FSO system by all-optical connection of free-space and SMF is show in Figure 18. Because the signal light is fiber coupled at both ends, booster/post EDFA and other measurement and data collection devices can be conveniently placed inside the building. The fibers are run to the respective rooftops and then coupled directly to the antenna as shown in Figure 16. Separation of transmitting light and receiving light is performed by an optical circulator. The test signal (pseudo random bit sequence) from bit error rate tester (BERT) is changed into a light signal by an E/O converter, and after being amplified with a booster EDFA, it is sent to the optical antenna of the rooftop. At the other end after the optical signal received with the optical antenna is removed in amplification by post-EDFA and a light filter removes noise, it is changed into an electric signal by an O/E converter, and becomes a receiving bit sequence in a clock data recovery circuit, and calculation of the bit error is carried out by BERT. The light signal which branched by 3 dB-coupler on the way is used for the monitor of receiving intensity, or other measurement. In a WDM experiment, the wavelength of each signal is made to fit the ITU grid (100 GHz channel spacing), and multi/de-multiplex is performed using a DWDM multi/de-multiplex device. Moreover, a weather monitor device and another optical antenna are installed in the rooftop and weather condition (visibility, precipitation and temperature) and link line condition (scintillation and optical power attenuation) are measured simultaneously.
A map view of the 1km test between Waseda University Nishi-Waseda campus and Okubo campus
Optical antennas on the rooftop of building 14 in Nishi-Waseda
Photograph of experimental hardware setup
Experimental FSO communication system setup
First, in order to evaluate the all-optical connection FSO system characteristic, the result of the 10 Gbps single wavelength light signal transmission experiment [Arimoto 2007] which is not achievable with conventional FSO system is shown in Figure 19. The bit error rate (BER) is measured by accumulated at 1 minute interval is shown in the figure. The data encoded optical signal, is amplified by 100 mW booster EDFA shown in Figure 18. The minimum receiving sensitivity of the optical receiver used in this experiment is -37 dBm. Stable transmission with few errors has been achieved over 12 hours. Figure 20 shows the eye patterns measured continuously for 5 minutes at this time. Although the fluctuation of the amplitude direction becomes large when compared with the eye patterns before transmission, it seems that there are very few increases in a time jitter (horizontal axis), and high-speed transmission is possible. In addition, the error sometimes shown in Figure 19 could be burst error produced by the momentary fall of received light intensity of several milliseconds or less, and this influence can hardly be observed on TCP/IP which is commonly used. An experiment using two optical wavelengths and connection to a Giga-bit Ethernet circuit and a 2.5 Gbps test signal was conducted. Optical and electrical signal conversion were performed by the media converter, and the Ethernet circuit performed huge size file transfer of between PCs connected through a switch, and has calculated the throughput from transfer time. In addition, it is connection by 100 Mbps between the switch and PC. Figure 21 shows the measurement result of the throughput of the file transfer performed for every minute and BER accumulated per minute. The minimum receiving sensitivity is -34 dBm which is almost same as the optical receiving module currently used for the media converter and the optical receiver currently used for BER measurement. Although errors sometime appeared in BER measurement, there is almost no change of a throughput almost similar result as in wired network. Since the great portion of error is short-time burst error, the throughput is hardly affected. Moreover, to the experimental result of BER and Ethernet, change considered to be mutual interference among other light signals cannot be found out at all, but has realized stable WDM transmission to it.
BER measurement result for 10 Gbps transmission over 1 km distance.
From these results, we demonstrated the next-generation FSO system using all-optical connection technology realized 10 Gbps transmission and also possible to apply WDM transmission which were not able to be realized in the conventional FSO system, and showed that the capability near an optical fiber could be offered. However in presence of strong atmospheric turbulence increased burst errors are observed in the system because of the fall in the received signal power. In order to realize stable communication even under strong atmospheric turbulence more improvement in is needed is required in the tracking system performance. Moreover, it is important to clarify the link design technique about the application distance of atmospheric turbulence and a FSO system.
Gbps transmission test eye pattern. (a) Before transmission (b) After 1 km transmission
The next-generation optical wireless communication system offered seamless connection of free space and fiber system. The transceiver incorporates a FPM for high-speed beam tracking and control function, therefore, having the capability to mitigate the effects of atmospheric turbulence on the transmitted optical beam. The FSO system performance was verified and error free transmission over an extended period of time was demonstrated. The system performance expressed in terms of BER performance was also evaluated and showed to be consistently above acceptable levels. Stable performance after increasing the system bandwidth using WDM technology was also attained.
Throughput and BER characteristics in DWDM transmission
Examination of a RoFSO system which expands RoF technology to a free-space using all-optical connection technology is shown. RoF technologies [Al-Raweshidy 2002][Hai 2006] can realize a cost effective universal platforms for future ubiquitous wireless services. Furthermore, RoF networks can be extended to virtual radio free-space network with layer 1 routing realized [Komaki 2003][Tsukamoto 2005]. By using RoF, architecture for radio access zones easily employs micro or pico cellular systems. However, the optical fiber as an infrastructure is needed for a RoF network. We aim at quick and effective provide of heterogeneous wireless services for not only urban area but rural area, that has a little or no infrastructure for broadband services by the system with which developed next-generation FSO and a RoF system were united.
Outline of RoFSO system setup
We developed the RoFSO antenna which is improved the optical antenna, and installed in the same experimental field [Kazaura 2009][ Kim 2009][Tsukamoto 2008]. Moreover, RF interface which represents the RoF system, and optical interface which performs multi/de-multiplex and amplification of the optical signal carrying the various services developed for an experiment as indoor equipment. A new optical antenna of 80 mm of the main aperture aimed at better tracking accuracy by feeding back the influence of the atmospheric fluctuation which signal light receives itself by diverting and using a part of signal light for fine tracking. RF interface unit consists of a RoF module which performs the electro/optical conversion of RF signal corresponding to the planned service (3G cellular, WLAN 11g/a, DBV-T), and its control circuit. Each light signal transmitted is matched with the ITU grid wavelength of a 100 GHz space. The optical interface unit consists of a DWDM multi/de-multiplex device, EDFA (booster/post) and optical circulator for separation of transmit/receive signal. A figure showing the whole system just described is depicted in Figure 22. In this experiment, signal generators and analyzers for evaluating the transmission quality of various services are connected to RF interface unit.
The average expansion and fluctuation of light intensity of the laser beam at 1.550 μm wavelength with the atmospheric turbulence are calculated by using the above expressions (Section 3). The relation between the beam radius at the transmitter and the average beam expansion at receiver point is shown in Figure 23.
Rx beam radius versus Tx beam radius
Scintillation index depend on Tx beam radius
Probability of fading level
According to these results, the radius of received beam is varied slightly and the expansion rate of the radius of received beam is constant when the radius of transmit beam is more than 20 mm. Moreover, the larger the transmission beam diameter is, the smaller the amount of the decrease of center strength of the received beam, and the free space transmission loss is less than 5 dB for a transmit beam diameter of 40 mm or more. We calculated the fluctuation of the received light intensity (scintillation index) by varying the transmitted beam radius. The result is shown in figure 24. The change is small in weak fluctuation case and there is no big received optical power changes for propagation distance of 1~2 km with laser beam transmit and receive aperture diameter of 10~100 mm therefore an optical antenna having this range of aperture beam transmission is possible. Figure 25 shows the cumulative probability distribution when the transmit beam radius is set at 40 mm and pointing error is 5 μradian. We found that the fluctuation of receiving optical intensity is ± 3 dB at 10 % and ± 8 dB at 0.001%. In other words, it is necessary to consider fading margins that are 9.6 dB for the uplink and 9.2 dB for the downlink if inoperable ratio is 10-7.
In addition, the previous NG-FSO system, the beam for fine tracking systems was a beacon light which was different from the signal light. In that case, the propagation path of the beacon light signal and signal beam is not exactly consistent therefore the atmospheric fluctuation behavior is also not similar. Especially, in the case of the data rate is high, such tendency is significantly. Therefore, it was not possible to get enough fine tracking characteristics. That is why in the new system for fine tracking the signal light is used for detection of angle of arrival by utilizing beam splitter.
Based on these calculations, if a diffraction-limited Gaussian beam is transmitted, it is desirable for the pointing error to be less than 5 μradian considering fading. The pointing error of the FPM used for the fine tracking of the RoFSO system is approximately 20 μradian and the angular magnification of the optical antenna is 40. The tracking accuracy of the entire system can be calculated by the division of those two values and it is 0.5 μradian. Thus, it is possible to expect the improvement of the atmosphere fluctuation.
A constitution of the prototype of the optical antenna module [Takahashi 2008] which had a QD feedback type built-in fine tracking system by a micro-miniaturized fine pointing mirror with the part of SMF coupling components is shown in figure 26, the photograph of SMF coupling part and tracking system is shown in figure 27 and the photograph of entire prototype optical system is shown in figure 28. Based on this design, results of the calculation of coupling efficiency and spot diagram when an ideal lens is deployed in the radiation side are shown in figure 29. The on-axis SMF coupling loss is -1.02 dB with less the -5 dB loss for up to full size field angle 25 μradian. Optical performance for on-axis and off-axis of the designed optical system is summarized in table 1. It is observed that it is possible to obtain almost twice image formation efficiency of the diffraction limit of the design requirement for field angle ±0.5 degrees.
Optical layout of the antenna of RoFSO system
Photograph of SMF coupling part and tracking system
Photograph of entire optical antenna of prototype RoFSO system
To evaluate real performance in the trial product; the coupling efficiency that measured in experiment system deploy a coupling lens after an object lens and a collimator, and to be received light to SMF is approximately - 5dB.
RoFSO antenna optical performance (a) Coupling efficiency (b) Spot diagram
Field angle (deg) | 0 | 0.5 | 1.0 |
Spot diameter (μm) | 2.7 | 2.9 | 6.2 |
Wave aberration (λ) | 0.0037 | 0.0094 | 0.0327 |
Coupling efficiency (dB) | -1.02 | - | - |
Optical performance of the RoFSO optical antenna in design condition
We installed the developed RoFSO system at a same place of NG-FSO system in Waseda University and performed experiments [Kazaura 2009] [Kim 2009] [Tsukamoto 2008] [Takahashi 2008]. Photographs showing the devices setup on the rooftop as well as the various measurement devices setup in the laboratory is depicted in Figure 30(a) and 30(b) respectively. Three FSO antennas are placed on the rooftop of one building as shown in Figure 30(a), which include the DWDM RoFSO antenna under investigation and two other conventional antennas used for measuring and quantifying the deployment environment characteristics for example atmospheric turbulence induced scintillation.
As a result, the system’s stability and tracking properties satisfied the design requirements (tracking response is more than 2 kHz, turbulence suppression characteristics of this feedback system are more than suppression ability 20 dB in frequency less than 100 Hz with Cn2 < 1.7×10-14), and we confirmed that the system can transmit WDM with sufficient performance regarding not only error-free transmission of digital signals but also RF signal transmission. Figure 31 shows the intensity fluctuation characteristics of received beam when the fine tracking of antenna is set OFF or ON, and the average of turbulence Cn2 is 2×10-14. If the fine tracking is set OFF, the fluctuation of receiving optical intensity largely and frequently decays because it is not possible to control arrival angle, also because location of beam spot of SMF consistently fluctuates. In addition, the mean of receiving optical intensity is low because it is not possible to control location of light focus accurately. On the other hand, the fine tracking of antenna is set to ON, the entire fluctuation decreases and the mean of receiving optical intensity is improved. Figure 32 shows the receiving optical spectrum when four of wireless service signals are transmitted with 1 km distance and WDM transmission using this RoFSO. It can be found that each service signal is clearly separated and is transmitted without mutual interaction.
RoFSO system experimental device (a) rooftop setup and (b) devices setup in the laboratory
Optical intensity fluctuation characteristics of received beam with tracking OFF (upper) and tracking ON (lower)
Optical spectrum of four wireless service signals using WDM RoFSO system
In W-CDMA system, the downlink signal transmitted by the base station is designed to fulfill the specifications set in 3GPP standard [3FPP 2002]. The spectral properties of the signal are measured by he adjacent channel leakage ratio (ACLR) which is considered to be a more stringent quality metric parameter, and is defined as the ratio of the amount of leakage power in an adjacent channel to the total transmitted power in the main channel. The 3GPP specifies one main channel and two adjacent channels. The standard requires the ACLR to be better than 45 dB at 5 MHz offset and 50 dB at 10 MHz offset. In our experimental setup, we use a signal generator to generate a test signal (W-CDMA Test Model 1) with a signal power of -20 dBm which is transmitted over the RoFSO link and at the receiver side a digital mobile radio transmission tester is used to measure and record the quality of the W-CDMA signal. Figure 33(a) shows a received W-CDMA signal ACLR spectrum after transmission over the 1 km RoFSO link. It is observed that the signals’ spectral properties shown on Figure 33(a) satisfy the 3GPP specified values of ACLR at the 5 MHz and 10 MHz offsets.
The variation of the measured received optical power and the W-CDMA signal ACLR characteristics is shown in Figure 33(b). Two cases are considered i.e. first case is back-to-back (B-to-B) measurement using the RoF modules, signal generator and analyzer and an optical attenuator for incrementing the attenuation to represent channel losses and in the offsets. The B-to-B actual transmission over the RoFSO system measurements shows almost similar characteristics and the minimum optical received power to satisfy the prescribed 3GPP value at 5 MHz at 10 MHz offsets is about -15 dBm. Using a post EDFA the required received optical power can be even as low as -25 dBm and -20 dBm and still satisfy the 3GPP specification for W-CDMA signal transmission at 5 MHz and 10 MHz offsets respectively.
a) Received W-CDMA signal ACLR spectrum and (b) variations of ACLR and optical received power
In another example the RoFSO system is evaluated by transmitting a WLAN IEEE802.11 based signal. In this experiment, an IEEE802.11g compliant waveform is generated by a vector signal generator at -24 dBm which is applied to the RoF module in the RF interface unit. After transmission through the RoFSO link a spectrum analyzer is utilized to measure and analyze the quality of the received WLAN signal. A pass/fail judgment of the spectrum mask as defined in the IEEE specification 802.11a/b/g is used. As a test signal, IEEE802.11g waveform at 2.4 GHz with 54 Mbps 64QAM is used. Figure 34(a) depicts a WLAN signal with spectrum mask in this case. A constellation graph of the WLAN signal modulation analysis is shown in Figure 34(b).
WLAN (a) spectrum mask and (b) modulation analysis constellation
The recorded RMS of Error Vector Magnitude (EVM) value is within the acceptable tolerance for WLAN signal transition. The result of continuous measurement of the spectral mask test collected over two days is shown in Figure 35. The mask pattern Pass/Fall judgment is measured per second and recorded. This result is accumulated for every 1 minute, and the passed number is plotted in the figure. Moreover, in order to evaluate the variation with respect to the condition of the propagation path, the metrological data such as visibility and rain rate data which is simultaneously collected is plotted.
Mask test pass counts per 1 min. vs. weather condition
The measurement data depicted in the figure represent a fine weather condition before noon on the first day which later turned cloudy. On the second day it rained. The drop in visibility because of rain is significant around 8:00am on the second day. Because of the rain there is an increase in attenuation in the propagation path, so the received optical signal power falls therefore increasing the rate of the spectrum mask test failure. It can be observed in the figure that on the first day, there is an increase of spectrum mask failure rate around noon, this is due to the effect of atmospheric turbulence.
Digital terrestrial television broadcasting, referred to as Integrated Service Digital Broadcasting – Terrestrial (ISDB-T) in Japan, is designed to provide reliable high-quality video, sound and data broadcasting not only for fixed receivers but also for mobile receivers. The system is designed to provide flexibility, expandability and interoperability for multimedia broadcast. The ISDB-T system uses the UHF band at frequencies between 470 MHz and 770 MHz, giving a total bandwidth of 300 MHz. The bandwidth is divided into 50 channels named from 13 to 62. Each channel is further divided into 13 OFDM segments which includes a single segment, (A-Layer or 1seg), for mobile receivers (LDTV, audio and data) and the remainder can be allocated as one 12-segment for high definition television (HDTV) programs [DiBEG]. In this setup, channel 32 is used for ISDB-T signal transmission. A vector signal generator (Anritsu MG3700A) is used to output simple BER data and video waveforms for ISDB-T transmission evaluation. In this example, two signals are set simultaneously with the following waveform patterns (a) ISDBT_16QAM_1_2 (A-Layer: 1seg, 16QAM and B-Layer: 12seg, 64QAM) and (b) ISDBT_2layer_Movie, both at -20 dBm with a 6 MHz frequency offset. The combined signal at -17 dBm is fed into the RoF module. The optical modulation index (OMI) for each channel (at -20 dBm input) is 10%. The signal is subsequently transmitted over the RoFSO link. At the receiving site a digital broadcasting signal analyzer (Anritsu MS8901A) is used to measure the quality of the received ISDB-T signal. A received signal spectrum showing the two transmitted ISDB-T signals is depicted in Figure 36(a). A modulation error ratio (MER) quality metric parameter used to evaluate the modulation signal quality of the digital terrestrial television broadcasting signal directly and quantitatively is measured and analyzed. An example of modulation analysis constellation for the digital terrestrial broadcasting signal made of A-Layer 16QAM and B-Layer 64QAM is shown in Figure 36(b) and 36 (c) respectively which were captured when the recorded average received optical power was -5.92 dBm and -5.88 dBm respectively (i.e. the monitor output measured power adjusted for the respective RF signal). The constellation is very useful for analyzing the condition of the received signal by monitoring the modulation symbol movement. In Figure 36(b) and 36(c) the received signals exhibit little signal distortion (in terms of amplitude or frequency fluctuations) and the signal deterioration is minimal thus confirming the suitability of the RoFSO system for ISDB-T signal transmission conforming to the specified standard [ARIB]. In this example the measurement was made in the evening after 20:00 hrs considered to be weak atmospheric turbulence conditions. The ISDB-T signal transmission using the RoFSO system is also evaluated using a BER quality metric parameter. Figure 37 shows the BER measurement and the mean received optical power characteristics for one-segment (1seg) and 12-segment transmission collected over a 24 hour period on 11 December 2008. Increased bit errors are observed at around midday because of increase in the atmospheric turbulence which affects the received optical power. The variation of the measured mean received optical power can be correlated with the BER in this case. For 1seg transmission (A-Layer) the BER characteristics shows satisfactory performance with most values being below the error correction limit (2×10-4) demonstrating the suitability of the RoFSO system for ISDB-T 1seg transmission. Unfortunately, occasionally the automatic gain control (AGC) is inadequate in the case for 12-segment HDTV (B-Layer) transmission. As an example the ISDB-T transmitted video captured screen shots for 1seg and 12-segment are shown in Figure 38(a) and 38(b) respectively. The 1seg video quality was consistently clear and continuous without any stoppages. However, the 12-segment video is clear and continuous only in the absence of atmospheric turbulence or other effects which contribute to the deterioration of the transmitted RoFSO signal quality.
ISDB-T signal transmission experiment (a) received ISDB-T signal spectrum and modulation analysis constellations for (b) A-Layer 1 Seg (16QAM) and (c) B-Layer (64QAM)
Digital terrestrial television broadcasting BER and received optical power characteristics
ISDB-T captured video screen shots (a) A-Layer 1seg and (b) B-Layer 12-segment
Simultaneous transmission of different kinds of wireless services using a newly developed RoFSO system has been presented. As the result, we have been presented that an all-optical connection FSO system could treat not only digital signal transmission but RF signal on a par with an optical fiber. And it is shown that the new generation optical wireless optical communication technology has a possibility of uniting radio environment and cable environment also with a service level, and the thing expectable as a solution of a heterogeneous network is shown.
We have described the concept and technology for the next-generation optical wireless communication systems. We explained the optics design method and the design results of the optical antennas considering laser propagation phenomena such as the scintillation and arrival beam angle fluctuation which occurs by atmospheric turbulence. We also mentioned the fine tracking mechanism using the FPM for the optical antennas. The FSO system incorporating high speed and highly precise tracking mechanism in which the influence of angle of arrival change is compensated succeed in maintaining free-space to SMF stably. A free-space optical communication system using specially designed compact antenna for easy, cost effective means of constructing a robust and reliable high-speed link for next generation optical wireless communication system was developed and investigated. The actual proof experiment using the developed NG-FSO system shows that this system enabled offer of a link equivalent to the fiber independent of the bit rate or a transmission protocol. Furthermore, we tried to unite this system with a RoF system and also enabled offer of various wireless services further. RoFSO system which expands RoF technology to a free-space using all-optical connection technology also shows the possibility of RF signal transmission through the field experiment. As these results, a next-generation optical wireless communication system using all-optical connection technology shows a possibility of becoming an effective solution of extension of a next-generation optical fiber system and heterogeneous wireless service.
Glaucoma is a complex progressive neurodegenerative eye disease characterized by progressive loss of retinal ganglion cells (RGCs) axons [1]. It is the leading cause of irreversible blindness worldwide. Primary open-angle glaucoma (POAG) is the most prevalent form of glaucoma and is responsible for ~90% of all cases. POAG is a multi-tissue disease that targets, in ascending order, the TM, the optic nerve head, the lateral geniculate nuclei and the visual cortex [1]. As is known to us, TM dysfunction induces impaired aqueous humor (AH) drainage, elevated IOP and alterations of the optic nerve head and the visual field defects in POAG [2, 3, 4, 5].
As the drainage of the AH outflow pathway, TM cells (TMCs) are constantly exposed to different types of stress such as mechanical, oxidative, and phagocytic stress during their lifetime. TMCs have cellular defense mechanisms including the antioxidant system, proteolytic system, and regulation of stress-responsive genes that allow them to cope with daily challenges. Since TMCs are known to be highly differentiated cells characterized by a low renewal rate, injured cells are not readily replaced and damage is not diluted through cell division, leading to the progressive acceleration of TM damage resulting in glaucoma [6, 7].
Although, significant advances in ophthalmologic knowledge and practice have been made, the mechanisms responsible for TM damage are not yet completely understood. Current treatment for POAG revolves around controlling IOP by drug, laser or surgical treatment, rather than preventing, reducing or repairing TM damage. Therefore, up to now, there is no effective treatment able to ensure healing. In this review, we summarize our current knowledge of the pathological mechanisms of glaucomatous TM damage, particularly focusing on linking the genetic factors of POAG (e.g., mutations and variants in POAG risk genes, risk loci, dysregulation of gene expression) to molecular pathways of pathogenesis in TM.
The TM is a highly specialized tissue with a small size (100–150 μg, containing approximately 200,000–300,000 cells) located at the angle formed by the cornea and the iris in anterior chamber (AC) [8]. The TM consists of three regions: the uveal meshwork (UM) which is adjacent to the anterior chamber, corneoscleral meshwork (CM) which is located at the middle layer, and juxtacanalicular tissue (JCT) which is made up of TM cells embedded in the extracellular matrix. The JCT is adjacent to the inner wall of Schlemm’s canal (SC) and is considered to offer the major resistance to the AH outflow (Figure 1). The AH is generated in the ciliary processes from arterial blood. Then AH reaches the anterior chamber from the posterior chamber by passing the pupil and flows out through the TM. After crossing the TM, AH reaches Schlemm’s canal, which drains directly to the aqueous veins. The TM is the main pathway (called the conventional pathway) for modulating AH outflow resistance. Approximately 10% of the remaining AH leaves the anterior chamber through the uveoscleral pathway (unconventional pathway).
The whole eye and the TM tissue were shown in both two-dimensionally and three-dimensionally to explain the AH outflow pathway. Normal IOP is required to maintain the proper physiological function and the structure of the globe of the eye. The IOP state critically depends on the balance between the inflow and outflow of AH. Malfunction of TM induces elevated IOP and alterations of the optic nerve head and the visual field defects. The TM consists of endothelial cells immersed in their fundamental substance. AH flows through the TM in both the intercellular route and the transcellular route.
Previously, AQP1, MGP, CHI3L1, TIMP3 and MYOC were used as typical TM markers. However, their application is hindered due to their limited specificity for distinguishing diverse cell types in a tissue. Larger-scale single-cell sequencing combining the
In POAG, TMCs undergo a series of molecular and morphological alterations which lead to a gradual decrease in their cell number and IOP elevation. The increase of IOP, in turn, results in other pathological alterations that further impair cell homeostasis, leading to a vicious circle [11].
TM fibrosis is a key pathological characteristic of POAG [12, 13]. Fibrosis results in increased ECM deposits both in the TM and in the lamina cribrosa (LC). Both aberrant stiffness of TMCs and abnormal accumulation of ECM components contribute to TM fibrosis, leading to AH outflow resistance and elevated IOP [13]. During the process of POAG, the TM displays several alterations on morphologies and functions, including cell loss, increased heterogeneity of TM cellularity, increased accumulation of ECM, reduced adhesion of TMCs to ECM, formation of cross-linked actin networks, endothelial dysregulation, changes in the cytoskeleton, altered motility, reduced adhesion of TMCs to ECM, subclinical inflammation, progressive senescence and outflow impairment [11, 12, 13, 14, 15]. TM damage might trigger cross-linked proteins formation within aging tissues with malfunctioning proteolytic and ECM remodeling, as well as apoptosis and cell loss [13]. The AH proteome profile also undergoes dramatic changes, reflecting cellular and molecular damage to the TM [14, 16].
Transforming growth factor-β (TGF-β) signaling is widely recognized as a core pathway of fibrosis. TGF-β2 expression is increased in the AH and TM of POAG eyes [12]. Activation of TGF-β2 signaling causes a significant increase in oxidative stress in TMCs [17]. Several studies have demonstrated that TGF-β is involved in TM damage: (1) TGF-β induces mitochondrial ROS generation, (2) ROS are required for TGF-β induced gene expression downstream of Smad3 phosphorylation and nuclear translocation, (3) TGF-β induced transcription of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 4 requires mitochondrial ROS forming a feedback loop leading to increased intracellular ROS, and (4) blocking ROS generation markedly reduces TM profibrotic gene expression induced by TGF-β [18, 19].
Clinical evidence also suggests that POAG patients exhibit features of impaired NO signaling. NO is produced in vascular endothelia by the enzyme endothelial NO synthase (eNOS). The previous studies have confirmed that eNOS is an important protein in IOP regulation through the conventional outflow pathway. In the TMCs, NO has a critical role on the relaxation of TM [20]. The down-regulation of eNOS activity and reduced availability of NO is associated with POAG. In animal model studies, increased eNOS levels in the mouse TM have been associated with a reduction of IOP [21]. Stamer et al. [21] reported that mice overexpressing NOS3 had lower IOP and increased outflow facility than wild type in mice. Conversely, increased IOP and reduced outflow facility were observed in the NOS3 KO mice [22]. Furthermore, exogenous NO donor compounds can reduce IOP and increase outflow facility in several animal models [23]. Recently, Patel et al. [23] show that fluid flow-induced shear stress activates TRPV4TM channels and induces eNOS-mediated NO production. The activity of TRPV4TM channels is impaired in glaucoma that render TM cells are insensitive to fluid flow-induced shear stress. TRPV4 channel activator can lowers IOP and improve outflow facility by increasing eNOS activity and production of NO in TM cells. This indicates an important role for TRPV4-eNOS signaling in IOP regulation. In addition, studies have also demonstrated the association of polymorphisms in the NOS3 gene, which encodes eNOS, with the development of glaucoma [24].
It is well known that several factors, including aging, genetic factors, environmental factors, and metabolites, involved in the onset and development of TM damage in POAG. Moreover, several mechanisms are triggered, leading to TM damage.
Oxidative stress is the exact and the most concerned mechanism leading to DNA, mitochondrial, and ECM damage in the TM and contributing to POAG pathogenesis [25, 26]. Several studies have demonstrated that TMCs are the most sensitive cell types to oxidant damage [25, 26]. The ability of TMCs to fight oxidative damage is critical to their survival and functions. Under normal circumstances, TM is exposed to a constant low level of oxidative stress and the expression of antioxidant enzymes makes TMC relatively resistant to oxidative damage. Excessive accumulation of reactive oxygen species (ROS) or an imbalance between oxidants and antioxidants may lead to oxidative stress in TMCs [27, 28]. The progress of POAG may be accompanied by a decrease in the antioxidant capacity of TMCs. Also, free radicals cause a gradual increase in oxidative damage, cytoskeletal changes and ECM accumulation in TMCs [29]. Oxidative damage to ECM adhesion results in damage to TM integrity, TM cell adhesion, and finally leads to cell loss [30]. As well, oxidative stress could damage the TMCs proliferation and migration function [17].
Inflammation is known to be increased in POAG patients [18, 19, 31]. The study revealed that cellular infiltration of immunocompetent cells (CD3+ and CD45+ cells) exists around the collector channels of the TM pathway in POAG [31]. Increased levels of inflammatory mediators, such as TGF-β1, TNF-α, and interleukins (e.g., IL-1α, IL-1β, IL-6, IL-8, IL-10, IL-20 family) were found in the TMCs and the AH of POAG patients and animal models [31, 32, 33]. These inflammatory mediators can induce changes in the ECM and the TMCs cytoskeleton, and have been shown to be associated with the pathogenesis of POAG [33]. Some factors, such as IL-1α, which is highly expressed in TMCs, can up-regulate the expression of other inflammatory mediators [31, 32, 33]. The up-regulation of inflammatory mediators, e.g., IL-1α, and IL-1β, induced by oxidative stress in TMCs were reported [34]. In addition, both NF-κB and arachidonic acid are inflammatory components that are known to be activated in the TMCs to protect against oxidative stress in POAG eyes [35, 36]. Along with the continued activation of inflammatory responses, TM exhibits decreased cellularity and irreversible damage. Prostaglandin analogues converted from arachidonic acid are currently used for the treatment of POAG. These prostaglandin analogues reduce IOP by increasing the outflow of AH [37, 38]. These results reinforce the association between inflammation and POAG pathogenesis.
Primary vascular dysregulation (PVD) is another potential mechanism of POAG pathogenesis. Most POAG patients have signs of decreased ocular blood flow and ocular ischemia in the eye, indicating that hemodynamic factors are also involved in the POAG process [39, 40, 41]. In POAG eyes, oxygen tension in the tissue often falls temporarily and very mildly. This fall occurs repeatedly over years and leads to a preconditional adaptation, making the TMCs more resistant to coming oxygen fall. When the oxygen fall exceeds a certain critical value, reperfusion damage occurs. If the oxygen drop lasts longer or greater, it can cause tissue infarction. In POAG, reperfusion damage is very mild but recurrent as well [41]. Recurrently mild reperfusion induces chronic oxidative stress and inflammation, which harms a diversity of molecules and reduces cellular survival. IOP fluctuation is more damaging than a stably increased IOP [42]. All POAG patients with elevated IOP or normal IOP suffer from autoregulation disorders [43], for which the main cause is PVD contributing via ischemia, hypoxia and oxidative stress to TM damage. Meanwhile, systemic oxidative stress is also associated with decreased ocular blood flow [44]. In addition, nitric oxide (NO) is an endothelium-derived relaxing factor, which improves ocular blood flow [20]. In patients with glaucoma, decreased NO production has been found in AH of POAG patients compared with controls [45].
Recent studies have revealed the role of chronic ER dysfunction of TM in the POAG process [46]. The ER is a vast membranous network and interacts with the ribosome, Golgi bodies, proteasomes and mitochondria. ER is a central organelle for of synthesis, modification, folding and maturation of proteins. Accumulation of unfolded and misfolded proteins in the ER would trigger activation of the unfolded protein response (UPR) pathways [2, 47]. UPR could be activated by increased protein synthesis, inhibition of protein glycosylation, the presence of mutant or misfolded proteins, imbalance of ER calcium levels, energy deprivation, hypoxia, pathogens or pathogen and toxins. PERK, a type I ER transmembrane kinase, is activated by ER stress. The activation of PERK leads to phosphorylation of the eukaryotic translation initiation factor (eIF2α), resulting in translational repression. On the other hand, under ER stress condition, transcription factor 4 (ATF4) is upregulated that leading to the increase of C/EBP homologous protein (CHOP) [47]. The activation of PERK-ATF4-CHOP persists during chronic ER stress and triggers cell death [2, 47, 48]. Expression of either ATF4 or CHOP promotes aberrant TMCs protein synthesis and ER client protein load, leading to ECM accumulation and TM dysfunction. The damaged ER activates inflammation via NF-κB, mitochondrial damages, and enhanced TM cell apoptosis, which leads to elevated IOP [48].
The normal function of the proteolytic system in TM plays a role in preventing POAG. Misfolded and mutated newly synthesized proteins are rapidly degraded to prevent the toxicity caused by protein accumulation [49]. The major proteolytic system includes the ubiquitin-proteasome system (UPS) and autophagy. PERK, IRE1α and ATF6α that are the three ER stress sensors that can regulate UPS and autophagy during the ER stress [50]. The protein degradation process regulated by UPR has great significance for the maintenance of normal function of TM. In most cases, the degradation of excessive proteins protects TMCs with stress survival from apoptosis [51, 52].
Autophagy is a fundamental process for the degradation or recycling of intracellular components, which promotes cell survival or promotes cell death in an environment-dependent manner [49]. On one hand, basal autophagy under physiological conditions is a cellular self-protection mechanism, protecting cell survival in the absence of energy or nutrients and responding to cytotoxic insults, which is critical to maintain cell homeostasis in synthesis, degradation and recycling of cell compounds [49, 50]. On the other hand, excessive stress-induced autophagy may cause cellular stress in turn and promote apoptosis or autophagic cell death [50, 51, 52, 53]. Autophagy selectively eliminates unwanted, potentially harmful cytosolic material, such as damaged mitochondria or protein aggregates. It is apparent that autophagy is impaired in TM pathologies [50].
Acute stress can initiate autophagosome formations and autophagic degradation [54]. However, the TM pathological processes of POAG are long-term chronic procedures instead of acute changes. When TM cells are chronically exposed to oxidative or other stress, significant functional damage to their lysosome system has been observed. The accumulation of nondegradable ECM resulting from impaired autophagy accelerates cell senescence [55]. These harmful processes contribute to TM structural and functional alterations. Porter et al. [54] revealed the activation of autophagy responding to chronic oxidative stress in TMCs is mTOR-dependent.
Oxidant stress, inflammation, ischemia, hypoxia ER stress, protein aggregation, metabolic block and other stress events as well as impaired cellular repairability, have been found to be involved in the induction of senescence of TM [56]. Senescent TM tissue presents an alternated morphological and molecular phenotype, including TM becomes more pigmented, the scleral spur becomes more evident, the trabeculae become flatter and gradually merges into each other, and the occurrence of the denudation of trabecular areas [57]. The increase in thickness of the sheaths of the elastic-like fibers is also observed in the cribriform layer of TM during the aging. The molecular alterations in TM during the aging include increased anti-apoptotic gene expression, chronic activation of the DNA-damage response (DDR), increased activity of the β-galactosidase associated with senescence (SA-β-Gal), lipofuscin accumulations in lysosomes, lysosomes accumulations, increased number of defective mitochondria and the activation of unfolded protein response (UPR) in the endoplasmic reticulum (ER). Moreover, a reduced ATP release in response to mechanical stress and a severe dysregulation of calcium homeostasis which can contribute to TM age-related damage were observed in TM senescent cells [58]. Decreased cellularity is another character in aging TM tissue. An approximately 60% of reduction is observed in TM cellularity associated with aging from 0 to 80 years, indicating there are fewer TM cells in aged glaucomatous human eyes compared to young, healthy human tissue [58].
Extracellular vesicles (EVs) allow the exchange of nucleotides, proteins and lipids between cells and mediate intracellular communication, which may play a key role in TM function and the POAG pathogenesis [59]. EVs are important constituents of the AH, which participates in the communication between the non-pigmented ciliary epithelium (NPCE) and the TM [60]. AH carrying EVs is produced by the NPCE and flows into the posterior chamber, which then moves into the anterior chamber and is finally drained through the TM and into the venous system [61]. Intercellular communication can be achieved by EVs membrane proteins that interact with the TMCs through endocytosis, phagocytosis or act as ligands for cell surface receptors on TMCs [62, 63, 64]. Interestingly, when TM is exposed to EVs, its ability to resist oxidative stress is enhanced [65]. EVs-mediated cell-to-cell communications between NPCE and TMCs are involved in the IOP regulation. When TMCs receive the wrong signal carried by EV from NPCE, TMCs will not be able to respond sensitively to maintain IOP homeostasis. Recurrent incorrect response patterns may lead to TM dysfunction and morphologic alterations. The canonical Wnt signaling may involved in the regulation of IOP and in the effects of NPCE-derived EVs on TMCs [65].
A substantial fraction of glaucoma cases is influenced by genetic factors. About 5–10% of POAG is currently attributed to single-gene (e.g., MYOC, CYP1B1, GLIS3, LOXL1, LTBP2, PITX2, EFEMP1 and OPTN) or Mendelian forms of glaucoma [66, 67, 68, 69]. Many of the remaining cases of POAG may due to the combined effects of multiple genes and the interactions of gene-environment. Genome-wide association studies (GWAS) have demonstrated many genomic loci are associated with POAG risk, including CDKN2B-AS1, TMCO1, CAV1, CAV2, SIX1, SIX6, AFAP1, ABCA1, TXNRD2, FOXC1/GMDS, ATXN2, FNDC3B, ABO, PMM2, ATOH7, TMCO1, and GAS7 [69]. Recently, a large multi-ethnic meta-analysis of genome-wide association studies identified 127 POAG risk loci, and of which 44 loci were previously unreported [70]. These genetic risk factors affect the development of POAG through a variety of pathological processes (Figure 2). Here we focus on several genes involved in the maintenance of TM functions and pathological processes of POAG.
Histopathological characters of trabecular meshwork (TM) damage in POAG. Implications for POAG pathogenesis: pathophysiological mechanisms of TM damage driven by oxidative stress and mitochondrial dysfunction, inflammation, vascular dysregulation and hypoxia, compromised autophagy, endoplasmic reticulum (ER) stress, abnormal intercellular communication and aging.
MYOC is the first gene identified to be involved in POAG. MYOC encodes the secreted protein myocilin, which is highly expressed in the TM cells. Mutations in MYOC were found with a high prevalence rate in patients with POAG of various populations. However, studies demonstrate that overexpression or knockout of Myoc in mice does not cause glaucoma, hinting a gain-of-function mechanism may be involved [71, 72]. Accumulating evidences indicate that mutant Myoc is misfolded and accumulates within TM cells, which promote ER stress [73, 74]. The ER stress activates the UPR signal, which protects the TM cells, corrects misfolding, prevents translation of misfolded proteins, prevents translation of misfolded proteins and degrades misfolded proteins. However, excessive and sustained ER stress can trigger apoptosis in the TMCs, which then leads to an increase in resistance to AH outflow and elevated IOP, and, ultimately, glaucoma.
GLI-similar 1-3 (GLIS1-3) constitute a subfamily of Krüppel-like zinc finger proteins that are involved in multiple biological processes by acting either as activators or repressors of gene transcription [75]. GLIS2 plays a critical role in the kidney and GLIS2 dysfunction leads to nephronophthisis, an end-stage, cystic renal disease [75]. GLIS3 plays a critical role in the regulation of multiple biological processes and is a key regulator of pancreatic β cell generation and maturation, insulin gene expression, thyroid hormone biosynthesis, spermatogenesis, and the maintenance of normal kidney functions [75]. GLIS3 genes have been associated with the increased risk of several diseases including glaucoma [75, 76]. GWAS studies have identified several SNP located in GLIS3, e.g., rs2224492 [76], rs736893 [77] and rs6476827 [78], associated with increased risk of POAG or raised IOP.
A previous study showed that GLIS1 significantly promotes the reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) [75]. Recently, Gharahkhani et al. [70] conducted a large multi-ethnic meta-analysis of genome-wide association studies and identified more novel loci for POAG risk, including GLIS1 locus (rs941125). The study by Nair et al. [79] demonstrates that the mice lacking GLIS1 developed enlarged eyes and a long-lasting increase in IOP. The study revealed that low levels of GLIS1 induce the degeneration of the TM, leading to inefficient drainage of the AH in mice. In addition, they showed that GLIS1 regulates the expression of several glaucoma-associated genes, e.g., MYOC, LTBP2, LOXL1, TGFBR3, ADAMTS10, CYP1B1, EFEMP1, MMP2, and several ECM-related genes including collagen I, IV, ADAMTS10, FBN2, LOXL1–4, and VI families, LTBP2, a regulator of TGFβ signaling and ECM deposition. In addition, the researchers also identified rs941125 at GLIS1 gene in humans are linked to risk of POAG. All these results indicate that GLIS1 is a key regulator in TMCs and a risk gene of glaucoma.
FOXC1 belongs to the Forkhead box (FOX) family of transcription factors and it is expressed in the adult eye including the TM. FOXC1 has been identified as a susceptibility locus for POAG and elevated IOP in several GWAS studies [76, 78, 80]. Mutations in the FOXC1 gene can cause Axenfeld-Rieger syndrome (ARS), a developmental disorder affecting structures in the anterior segment of the eye with an increase in IOP [80]. More than half of ARS patients with FOXC1 mutations will develop earlier-onset glaucoma. FOXC1 is expressed in ocular tissues including TM. Several genes that have TM relevant functions including miR-204, OLFM3, CXCL6, MEIS2, LDLRAD2, CLOCK and ITGb1 expressions was affected by FOXC1 in TM cells [81]. FOXC1 has been demonstrated to be a critical regulator for stress response [82]. The TM is the most sensitive tissue of the anterior segment of the eye to oxidative stress. Studies demonstrate that reduced FOXC1 expression increases cell death in cultured TM cells in response to oxidative stress, suggesting FOXC1 have a role in preventing cell death under both normal and oxidative stress conditions [82, 83]. HSPA6, a member of the heat-shock 70 family of proteins, has been identified as a target gene of FOXC1 [83]. HSPA6 protein is induced under severe oxidative stress conditions, has a protective function in TM cells. A decrease in FOXC1 results in the repression of several anti-apoptotic genes, including FOXO1A [82]. FOXO1A is a key protein in cellular stress response and apoptotic pathways, its expression is directly regulated by FOXC1 in TM cells [82]. Studies have shown that the FOXC1 gene also was involved in the regulation of prostaglandin receptor genes [84]. Doucette et al. [84] confirmed that FOXC1 binds to enhancer element of EP3 gene prostaglandin receptor (PTGER3) and activates PTGER3 expression. Other prostaglandin receptor genes EP1 (PTGER1), EP2 (PTGER2), EP4 (PTGER4), and FP (PTGFR) were altered when FOXC1 was knocked down in culture TM cells. This study provides a clue to explain why some glaucomatous patients do not respond to treatment of Prostaglandin analogs. Prostaglandin analogs (e.g., latanoprost, bimatoprost, travoprost, and tafluprost) are the frontline medications used to lower IOP in glaucomatous patients. However, about 30% of patients do not respond to these medications. Furthermore, 50–60% of patients with secondary glaucoma caused by FOXC1-mediated ARS did not respond to these medications. FOXC1 mutation or reduction of expression leads to the dysregulation of the prostaglandin signaling pathway, which probably account for the lacking of response to prostaglandin-based medications [84].
ATXN2 is a ubiquitous RNA-binding protein with a polyglutamine (polyQ) CAG repeat in its coding region. ATXN2 has roles in regulating many cellular processes, including stress granule formation, starvation and stress response, translation, RNA processing, metabolism, mitochondrial function, and calcium signaling [85, 86]. Expansions of polyglutamine repeat of ATXN2 have been implicated in spinocerebellar ataxia 2 (SCA2) and amyotrophic lateral sclerosis (ALS) [83]. In addition to causing SCA2 and increasing the risk of developing ALS, mutations in ATXN2 may play a role in a handful of other diseases, including Parkinson’s disease (PD), spinocerebellar ataxia type I (SCA1), Machado-Joseph Disease (SCA3), tauopathies, POAG, obesity and type I diabetes [85, 86].
In eukaryotic cells, various cellular stresses (e.g., starvation, heat shock, ER stress, oxidative stress) elicit the formation of cytoplasmic stress granules (SGs) as a part of the homeostatic response [87]. SGs contain non-translating mRNAs, translation initiation factors, and RBPs, which protect cells from damaging signals and suppress general translation. SG formation is beneficial for cell survival by preventing the accumulation of misfolded proteins and mutant proteins. Furthermore, upon the environmental stresses, SGs sequester several apoptosis regulatory factors into granules and thereby inhibit stress-induced cell death signaling. Since TM cells are exposed to various stresses simultaneously during their lifetime, the formation of SGs under multiple stress conditions is important for the function maintenance of TM cells.
Mutations of ATXN2 have been linked to impaired formation of stress granule in normotensive glaucoma, primary open-angle glaucoma, SCA2, and ALS [85]. ATXN2, ATXN2L, and their associating proteins have been identified as key components of mammalian SGs. Depletion of ATXN2 suppresses the SGs formation. ATXN2 repeat expansions impair the assembly of stress granule, leading to stress-granule-induced cytotoxicity and neurodegeneration. Studies show that inhibition of SGs assembly could promote apoptosis of cells [88]. Clearing of SGs involves in the autophagy pathway. Polyglutamine expansions in ATXN2 have been associated with autophagic and mitochondrial dysfunction in several neurodegenerative diseases. The study finds that the SCA2 cells expressing expanded ataxin-2 are particularly susceptible to autophagic inhibition when cells were treated with autophagy inhibitor chloroquine [89]. This treatment led to more apoptosis in SCA2 cells compare to controls, hinting that the SCA2 cells are more susceptible for autophagic inhibition [89]. This could be explained that ATXN2 is an inhibitor of mTOR signaling [90]. MTOR has been characterized as a negative regulator of autophagy [91]. This suggests that mutation of ATXN2 may lead to compromised autophagy by reducing inhibition of mTOR signaling.
Besides, GWAS study have identified ATXN2 were associated with risk for POAG [78, 79]. Expression analysis reveals that ATXN2 is expressed in the cornea, trabecular meshwork, ciliary body, retina and optic nerve [92]. It has the strongest expression in RGCs [92] and this result is confirmed by the expression profile from scRNAseq [10]. The expression of ATXN2 in key POAG-relevant ocular tissues supports its potential role in autophagy and stress granule formation in response to ocular hypertension.
EFEMP1 encodes fibulin-3, an extracellular matrix protein that serves to modulate cellular behavior and functions by connecting and integrating multiple partner molecules in the extracellular compartment. It is expressed in the retina and RPE, involved in age-related macular degeneration (AMD) [93, 94]. A GWAS identified copy number variation (CNV) at NPHP1 and EFEMP1 as potential candidates for the association of inherited retinal degenerative diseases [95]. The EFEMP1 gene was located within the GLC1H locus on chromosome 2p (2p15-p16). A report located a genetic locus (GLC1H) for adult-onset POAG maps to the 2p15-p16 region with linkage analysis in an Afro-Caribbean (Jamaican) population [96]. In another study, a region on chr2 (chr2: 46.4 M–65.6 M) was located that contributed to POAG with family-linkage analysis studies in Chinese [97, 98], which is overlapped with the 2p15-p16 region. A study identified a novel missense variant (p.Arg140Trp) in exon 5 of the gene coding for EFEMP1 that cosegregated with POAG in an African-American family [99]. Recently several GWAS studies have demonstrated that EFEMP1 is associated with increased risk for increased IOP for POAG [66, 78, 100]. In addition, mutations in EFEMP1 also were identified in sporadic POAG patients [68]. EFEMP1 is regulated by GLIS1 in TM cells [79]. Altered cell-ECM interaction or abnormal ECM organization was observed in Glis1-KO mice [79]. Furthermore, analysis of single-cell sequencing revealed that EFEMP1 is high expressed in Fibroblast, JCT and BeamB in TM region [10], indicating EFEMP1 plays a critical regulatory role in maintaining the structural integrity and functionality of the TM. As described in the previous section, TGF-β2 is significantly increased in the AH of patients with POAG. Expression analysis showed that EFEMP1 can be downregulated by TGF-β2 in cultured HTM cells [101], indicating the function of EFEMP1 may be impaired in TM in some POAG patients.
LOXL1 is a member of the lysyl oxidase family involving in extracellular matrix formation. This enzyme is required for linking collagen and elastin in connective tissues and catalyzing the polymerization of tropoelastin to form the mature elastin polymer. Previously, it was thought that the LOXL1 gene was associated only with XFG [102]. The allele T for the intronic SNP (rs2165241), and the allele G for both coding SNPs (rs1048661 and rs3825942) are associated with a higher risk of XFS and XFG in the studied population [102]. It seems that low levels of LOXL1 expression could predispose to XFS. No association was seen with POAG in that study. However, several recent GWAS studies in different ethnic populations have demonstrated that LOXL1 was associated with risk for POAG [70, 103, 104, 105].
LOXL1 expression is detected in ocular tissues such as lamina cribrosa, lens epithelium, cornea, ciliary muscle, and trabecular meshwork, all of which are mainly involved in the formation of the extracellular matrix. Profile of expression from scRNAseq revealed LOXL1 is predominantly expressed in TM (BeamB, JCT, and BeamA) [10]. In TM cells, LOXL1 is regulated by GLIS1. When GLIS1 was knocked down by shRNA lentivirus in HTM cells, the expression of LOXL1 was reduced [102]. ChIP-Seq analyses revealed that LOXL1 is directly regulated by GLIS1 protein binding to its promoter [79].
Glaucoma is age-related disease in human. Recent research suggests that epigenetics, especially DNA methylation, plays a critical role in aging. One proposed cause of aging is the disruption of epigenetic-sensitive molecular networks, which lead to decreased tissue function. Several evidences of LOXL1 epigenetic silencing by promoter methylation were reported in cancer and Cutis Laxa, a disorder of connective tissue [106, 107, 108]. Ye et al. reported that the promoter region of the LOXL1 gene was hypermethylated in patients with Pseudoexfoliation Glaucoma (PXFG) compared with controls, leading to a reduced expression of its protein product and downstream impaired elastic fiber homeostasis [107]. Similarly, Greene et al. [109] also discovered that the LOXL1 promoter methylation was increased in patients with PXFG compared to Control. These results indicated that hypermethylation of CpG islands in the LOXL1 gene may function as an essential mechanism in the pathogenesis of PXFG Glaucoma. In addition, the rare variant that probably impacts the function of LOXL1 protein was discovered in sporadic cases of POAG [68]. In our recent report, we found a rare variant (p.Cys448Phe) occurred in the LOXL1 protein lysyl oxidase domain [68]. This site is a conserved residue since the 443–456 sites are highly conserved in this domain, and several copper ion binding sites (His449, His451, and H453) are located in this region. It is worth noting that Cys448 and Cys497 will form a disulfide bond and the alternation of amino acid (from Cys to Phe) may lead to breakage of the S–S bond. These multiple lines of evidence indicate that the loss or decrease of LOXL1 function is related to Glaucoma, and it may also be an important risk factor for POAG.
Different worldwide treatment recommendations and guidelines exist for the management of POAG [110, 111, 112, 113]. IOP is the main modifiable risk factor proven to alter the disease course in these guidelines. IOP lowering can be achieved by medication, laser or surgery (either alone or in combination). Moreover, nutrients in the foods that we consume every day can alter gene expression in cells, thereby exerting a beneficial or harmful physiological effect. Lifestyle, exercise, and nutrients therefore play a key role in eye health and could be used as an adjuvant in POAG therapy [114, 115].
Re-cellularization of the trabecular meshwork (TM) using stem cells is a potential novel treatment for POAG. Recent experimental studies demonstrated the potential effectiveness of regenerative therapies using iPSCs or TM progenitor cells in restoring TM tissue and reducing IOP. however, the potential plasticity and the lack of definitive cell markers for TM cells compound the biological challenge. Morphological and differential gene expression of TM cells located within different regions made it difficult to regenerate [116]. Here, we will not describe the detail of these novel therapies.
Topical IOP-lowering medications have long been the POAG treatment and are widely used. The prostaglandin analogues reduce IOP by increasing the outflow of AH, primarily through the uveoscleral pathway [37]. They have also been shown to remodel ECM within the TM and reduce outflow resistance [38]. Prostaglandins became the first-line medication for POAG because of their IOP-lowering efficacy, once daily application and minimal systemic side-effects. Long-term use of PGA has been reported to decrease the central corneal thickness due to activation of corneal stromal matrix metalloproteinases (MMPs) [117, 118, 119, 120]. The other ophthalmic medication classes used in clinical practice include the beta-adrenergic blocking agents, the alpha-2 adrenergic agonists, and the carbonic anhydrase inhibitors [118, 119]. They can cause multiple ocular and systemic side-effects with poor compliance, which limits their clinical use.
Newer medical treatments are in development, including trabodenoson (a highly selective adenosine-1 receptor agonist), netarsudil (a Rho-kinase inhibitor and norepinephrine transporter inhibitor), latanoprostene bunod (a modified prostaglandin analogue), ONO-9054 (a novel non-selective prostanoid receptor agonist, dual EP3 and FP agonist) and others. Theoretically, most of these medicines are IOP-lowering treatments with new mechanisms of action, better efficacy, tolerability and convenience. The results of clinical trials including phase 3 trials were concluded successively [120, 121, 122, 123, 124, 125, 126, 127, 128, 129, 130].
As novel candidates for POAG, the ATP channel openers have been reported to protect the retinal ganglion cells during ischemic stress and glutamate-induced toxicity suggesting a neuroprotective property for this drug class [131].
Selective laser trabeculoplasty (SLT) is a viable alternative ophthalmic treatment when patients experience ocular or systemic side effects due to medication. SLT is relatively safe and well-tolerated with low complication rates [132]. Recently, the laser in glaucoma and ocular hypertension (LiGHT) study [133] has evaluated treatment-naive patients with POAG or ocular hypertension randomly allocated to receive either initial primary SLT or initial topical medication. The LiGHT study demonstrates that there is no difference in health-related quality of life (HRQL) between primary SLT and initial topical medication at 36 months. It provides good IOP control, at a lower cost and allowed almost 74% of patients to be successfully controlled without drops for at least 3 years after starting treatment. The study demonstrates that SLT is safe and effective as a first-line treatment for POAG and should be offered as an alternative to IOP-lowering topical medication. Other laser trabeculoplasty procedures include Micropulse Diode Laser Trabeculoplasty (MDMT), Titanium Sapphire Laser Trabeculoplasty (TLT) and Pattern Scanning Laser Trabeculoplasty (PSLT) [132, 133]. Some small studies have compared their efficacy against SLT and found their potential advantages. However, larger studies are required to support whether any of them provide extra advantages over existing SLT.
Several different glaucoma IOP-lowering surgeries exist, including penetrating (trabeculectomy, tube surgery, etc.), and non-penetrating surgery (deep sclerectomy, visco-canalostomy, and canaloplasty, etc.). Their use in clinical practice should consider not only the evidence of lowering intraocular pressure and the safety of each operation, but also the individual patient’s status. The decreases of IOP often were observed after cataract surgery [134, 135]. Cataract surgery has been described as the single best glaucoma surgery due to its IOP-lowering effect. Thus, clinicians may serve phacoemulsification as a valid treatment option for newly diagnosed POAG. The incisional operation generally achieves greater IOP lowering compared to medication and is usually performed if IOP lowering is insufficient by medication or laser [135]. But it may be a viable first option in those newly diagnosed POAG patients with a poor compliance or intolerant to medication. The Treatment of Advanced Glaucoma Study (TAGS) is currently investigating whether the surgical intervention could be the first treatment option in newly diagnosed advanced POAG [136].
Antioxidants can be grouped into two categories: enzymatic and nonenzymatic [148, 149, 150]. The enzymatic antioxidants, including superoxide dismutase, catalase, glutathione reductase, glutathione peroxidase and glutathione-S-transferase to scavenge the ROS in the body.
Disorders of glutathione peroxidase (Gpx) and nitric oxide synthase (NOS) are associated with glaucoma. Gpx can regulate ROS, while the NOS can produce nitrogen species (RNS). Lower plasma levels of both glutathione and glutathione peroxidase were found in POAG patients compared to controls [151]. In contrast, a significant increase in glutathione peroxidase activity in the AH and plasma of POAG patients have been reported by others [148, 149]. This divergence might be caused by the fact that antioxidant defense is decreased in patients with glaucoma, which results in an increase in the activity of antioxidant enzymes in an attempt to counteract the damage caused by ROS.
Ingested nitrate is turned into the vasodilator NO which improves ocular blood flow [148, 149, 150]. NO is also produced by the endothelium of the TM. The abnormal function of TMCs is associated with reduced NO bioavailability. The TM experiences physiological shear stress which triggers NO production. These cells may get lost as glaucoma progresses.
Non-enzymatic antioxidants including vitamins, carotenoids, polyphenols and flavonoids were intensively studied in POAG pathology [148]. Intake of vitamin A, C, E, B3 (nicotinamide), showed a beneficial association with glaucoma, improve inner retinal function [152, 153, 154]. Low vitamin D has been identified by some studies as an independent risk factor for glaucoma [155]. Vitamin D probably serves as an anti-inflammatory agent in the oxidative stress-driven pathogenesis of POAG. Coenzyme Q acts as another antioxidant similar to vitamins and was suggested to have the neuroprotective efficacy in glaucoma models [156]. In clinical studies, increased levels of carotenoids in macular pigment can help improve visual performance in glaucoma patients [157]. Astaxanthin features some important biologic properties, mostly represented by the strong antioxidant, anti-inflammatory and antiapoptotic activities. Both astaxanthin and saffron might be efficacious in the prevention and treatment of glaucoma [158, 159].
Polyphenols are plant-derived organic substances. Polyphenols can be divided into different subclasses, according to the number of phenolic rings present in their structure [160]. They comprise 4 families: simple phenolic acids, stilbenes (e.g., resveratrol), coumarins and flavonoids. Flavonoids include anthoxanthins, flavanones, flavanonols, flavans and anthocyanins. Flavonoids are widespread in nature, being found in a vast range of plants, including citrus fruits, grapes, tomatoes, berries and green tea; more than 5000 compounds that exert beneficial effects on health are known. These substances can protect cells or mitochondria from oxidative stress through different mechanisms and could offer therapeutic benefits to POAG patients [160].
Quercetin is a natural flavanol antioxidant and it has been reported to have notable curative effects on the treatment of glaucoma [161]. Baicalein has antioxidant and anti-inflammatory properties and can improve the treatment of glaucoma [162]. Curcumin reduces the inflammatory response by inhibiting the release of TNF-α and C-reactive protein and induces the expression of antioxidant enzymes or cytoprotective proteins [163, 164]. Resveratrol has been shown to increase the survival of retinal ganglion cells following ischemia-reperfusion injury for glaucoma in a study [165]. Meanwhile, resveratrol protects optic nerve head astrocytes from oxidative stress-Induced cell death through inhibiting the activation of caspase-3 activation, the dephosphorylation Ser 422 of Tau and the formation of misfolded protein aggregates [166]. Hesperidin, betalain and trehalose exert protective effects against glaucoma [167, 168, 169]. Polyphenols reduce inflammation through several mechanisms, such as reducing the expression of cytokines like IL-2, IL-6 and TNF-alpha [160]. Salidroside could inhibit TGF-β2-induced ECM expression in TMCs, and lower IOP which was elevated by TGF-β2 overexpression in mouse model [170]. Myricetin, is present in apples, oranges, berries, and vegetables. As a flavonoid, it can reduce oxidative stress and improve ocular blood flow in POAG. In POAG TMC, myricetin can substantially down-regulate the expression of TGFβ1/β2 [171, 172]. Myricetin effectively prevented IOP elevation and decreased IL-1α, IL-1β, IL-6, Il-8 and TNF-α) in the AH and TMCs in glaucoma rat model [172]. The results of these suggest that the intake of antioxidants in the diet could reduce the risk of glaucoma. The evidence is not conclusive; thus, more researches and long-term observations are required to evaluate the role of nutritional supplementation in glaucoma. The systemic status of these antioxidants in the tear, aqueous and vitreous fluid, as well as plasma, is a prospective gap in research.
Omega-3 (ω-3) fatty acids belong to the long-chain polyunsaturated fatty acid (PUFA) family. They have several properties that make them a potential adjuvant therapeutic agent in POAG. The first is that derivatives of ω-3 are the eicosanoids. These include the prostaglandin analogues, which are known for their IOP-lowering effect [38, 173]. Meanwhile, ω-3 exerts a highly protective effect on endothelial cells [174]. Omega-3 PUFA could reduce blood viscosity, probably because they improve the deformability of the red blood cells [175]. The anti-inflammatory properties of Omega-3 have also been demonstrated, which may have therapeutic potential for chronic inflammatory diseases such as glaucoma [176]. A high omega-3:6 ratio is recommended. Wang et al. [177] found that increasing the daily dietary intake of PUFA, including ω-3 fatty acids, was associated with a significant decrease in the probability of POAG. Finally, oral omega-3 supplementation for 3 months has been seen to significantly reduce IOP in normotensive adults [178] and in pseudoexfoliative glaucoma [179].
More and more evidences show that the onset of glaucoma is a result of the interaction of age, external environmental factors and genetic factors. The external environmental factors gradually impair the function of some key genes in the TM cell through a variety of ways, including decreased gene expression by cytokines, or epigenetic modification, which gradually change the phenotype of cells. Similarly, genetic factors (e.g., mutations of gene or polymorphism of POAG-associated genes) also lead to the gradual function impair in TM cells by influencing key regulatory pathways. There are some common signal pathways affected by genetic factors and environmental factors. Thus, the detailed characterization of the molecular profile of pathological and normal TMCs is critical to discover key regulatory molecules and pathways, which is the foundation for discovering the potential therapeutic targets. Simply reducing IOP by drugs, laser or surgery is not sufficient to guarantee a good prognosis in this disease. Therapies that focus on restoring TM cellularity and function could offer therapeutic benefits to POAG patients. The search for bioactive compounds with a protective effect on TM is of particular interest.
This work was supported in part by the projects (cstc2020jxjl130015, cstc2021jcyj-msxmX0767, and cstc2018jcyjAX0460) from the Natural Science Foundation of Chongqing.
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\n\nSljedeća terminologija odnosi se na Odredbe i uvjete, te na sve naše ugovore:
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\n\nAko smatrate da je bilo koja poveznica na našoj stranici sumnjiva iz bilo kojeg razloga, molimo vas da nas kontaktirate. U tom slučaju razmotrit ćemo micanje poveznice s naše stranice, iako nismo obvezni to napraviti.
\n\nBez prethodne privole i izričite pisane dozvole, ne možete stvarati okvire oko naših stranica ili koristiti druge tehnike koje na bilo koji način mogu promijeniti prezentaciju ili izgled naše stranice.
\n\nIntechOpen može ove Odredbe izmijeniti u bilo koje vrijeme i bez prethodne obavijesti. Koristeći ovu stranicu vi se slažete s trenutnim Odredbama i uvjetima koje su na snazi.
\n\nOve Odredbe i uvjeti su sastavljeni u skladu s odredbama prava Ujedinjenog Kraljevstva, a za sve sporove nadležan je sud u Londonu, Ujedinjeno Kraljevstvo.
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Repetto"}]},{id:"41116",doi:"10.5772/51572",title:"Algal Polysaccharides, Novel Applications and Outlook",slug:"algal-polysaccharides-novel-applications-and-outlook",totalDownloads:14079,totalCrossrefCites:71,totalDimensionsCites:187,abstract:null,book:{id:"2323",slug:"carbohydrates-comprehensive-studies-on-glycobiology-and-glycotechnology",title:"Carbohydrates",fullTitle:"Carbohydrates - Comprehensive Studies on Glycobiology and Glycotechnology"},signatures:"Stefan Kraan",authors:[{id:"142720",title:"Dr.",name:"Stefan",middleName:null,surname:"Kraan",slug:"stefan-kraan",fullName:"Stefan Kraan"}]},{id:"40938",doi:"10.5772/48294",title:"Dehydrogenase Activity in the Soil Environment",slug:"dehydrogenase-activity-in-the-soil-environment",totalDownloads:6940,totalCrossrefCites:72,totalDimensionsCites:182,abstract:null,book:{id:"2524",slug:"dehydrogenases",title:"Dehydrogenases",fullTitle:"Dehydrogenases"},signatures:"Agnieszka Wolińska and Zofia 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This chapter aims specifically at the mechanism of solubility of polysaccharides from the molecular level. General understandings of the solubility including definition, testing methods, and the solution behaviors were provided; the relationships between polysaccharide solubility and the structural features in terms of molecular weight, degree of branching, charging properties, chain flexibility, and the special groups were all discussed. With all the information provided, the molecular modification and further applications of polysaccharides in both food and nonfood areas could be promoted.",book:{id:"5935",slug:"solubility-of-polysaccharides",title:"Solubility of Polysaccharides",fullTitle:"Solubility of Polysaccharides"},signatures:"Mark Q. 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Mainly, the versatile techniques of ultra−/high-performance liquid chromatography (UPLC/HPLC) are in use for the analysis of assay and organic impurities/related substances/degradation products of a drug substance or drug product or intermediate or raw material of pharmaceuticals. A suitable analytical method is developed only after evaluating the major and critical separation parameters of chromatography (examples for UPLC/HPLC are selection of diluent, wavelength, detector, stationary phase, column temperature, flow rate, solvent system, elution mode, and injection volume, etc.). The analytical method development is a process of proving the developed analytical method is suitable for its intended use for the quantitative estimation of the targeted analyte present in pharmaceutical drugs. 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RNA‐seq data analyses typically consist of (1) accurate mapping of millions of short sequencing reads to a reference genome, including the identification of splicing events; (2) quantifying expression levels of genes, transcripts, and exons; (3) differential analysis of gene expression among different biological conditions; and (4) biological interpretation of differentially expressed genes. Despite the fact that multiple algorithms pertinent to basic analyses have been developed, there are still a variety of unresolved questions. In this chapter, we review the main tools and algorithms currently available for RNA‐seq data analyses, and our goal is to help RNA‐seq data analysts to make an informed choice of tools in practical RNA‐seq data analysis. In the meantime, RNA‐seq is evolving rapidly, and newer sequencing technologies are briefly introduced, including stranded RNA‐seq, targeted RNA‐seq, and single‐cell RNA‐seq.",book:{id:"5160",slug:"bioinformatics-updated-features-and-applications",title:"Bioinformatics",fullTitle:"Bioinformatics - Updated Features and Applications"},signatures:"Shanrong Zhao, Baohong Zhang, Ying Zhang, William Gordon,\nSarah Du, Theresa Paradis, Michael Vincent and David von Schack",authors:[{id:"176364",title:"Dr.",name:"Shanrong",middleName:null,surname:"Zhao",slug:"shanrong-zhao",fullName:"Shanrong Zhao"}]},{id:"49873",title:"An Introduction to Actinobacteria",slug:"an-introduction-to-actinobacteria",totalDownloads:8178,totalCrossrefCites:33,totalDimensionsCites:108,abstract:"Actinobacteria, which share the characteristics of both bacteria and fungi, are widely distributed in both terrestrial and aquatic ecosystems, mainly in soil, where they play an essential role in recycling refractory biomaterials by decomposing complex mixtures of polymers in dead plants and animals and fungal materials. They are considered as the biotechnologically valuable bacteria that are exploited for its secondary metabolite production. Approximately, 10,000 bioactive metabolites are produced by Actinobacteria, which is 45% of all bioactive microbial metabolites discovered. Especially Streptomyces species produce industrially important microorganisms as they are a rich source of several useful bioactive natural products with potential applications. Though it has various applications, some Actinobacteria have its own negative effect against plants, animals, and humans. On this context, this chapter summarizes the general characteristics of Actinobacteria, its habitat, systematic classification, various biotechnological applications, and negative impact on plants and animals.",book:{id:"5056",slug:"actinobacteria-basics-and-biotechnological-applications",title:"Actinobacteria",fullTitle:"Actinobacteria - Basics and Biotechnological Applications"},signatures:"Ranjani Anandan, Dhanasekaran Dharumadurai and Gopinath\nPonnusamy Manogaran",authors:[{id:"48914",title:"Dr.",name:"Dharumadurai",middleName:null,surname:"Dhanasekaran",slug:"dharumadurai-dhanasekaran",fullName:"Dharumadurai Dhanasekaran"}]},{id:"72074",title:"The Chemistry Behind Plant DNA Isolation Protocols",slug:"the-chemistry-behind-plant-dna-isolation-protocols",totalDownloads:3797,totalCrossrefCites:4,totalDimensionsCites:7,abstract:"Various plant species are biochemically heterogeneous in nature, a single deoxyribose nucleic acid (DNA) isolation protocol may not be suitable. There have been continuous modification and standardization in DNA isolation protocols. Most of the plant DNA isolation protocols used today are modified versions of hexadecyltrimethyl-ammonium bromide (CTAB) extraction procedure. Modification is usually performed in the concentration of chemicals used during the extraction procedure according to the plant species and plant part used. Thus, understanding the role of each chemical (viz. CTAB, NaCl, PVP, ethanol, and isopropanol) used during the DNA extraction procedure will benefit to set or modify protocols for more precisions. A review of the chemicals used in the CTAB method of DNA extraction and their probable functions on the highly evolved yet complex to students and researchers has been summarized.",book:{id:"8912",slug:"biochemical-analysis-tools-methods-for-bio-molecules-studies",title:"Biochemical Analysis Tools",fullTitle:"Biochemical Analysis Tools - Methods for Bio-Molecules Studies"},signatures:"Jina Heikrujam, Rajkumar Kishor and Pranab Behari Mazumder",authors:[{id:"74521",title:"Dr.",name:"Rajkumar",middleName:null,surname:"Kishor",slug:"rajkumar-kishor",fullName:"Rajkumar Kishor"},{id:"309357",title:"Prof.",name:"Pranab Behari",middleName:null,surname:"Mazumder",slug:"pranab-behari-mazumder",fullName:"Pranab Behari Mazumder"},{id:"318351",title:"Ph.D. Student",name:"Jina",middleName:null,surname:"Heikrujam",slug:"jina-heikrujam",fullName:"Jina Heikrujam"}]}],onlineFirstChaptersFilter:{topicId:"6",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"83015",title:"Acute Changes in Lipoprotein-Associated Oxidative Stress",slug:"acute-changes-in-lipoprotein-associated-oxidative-stress",totalDownloads:0,totalDimensionsCites:null,doi:"10.5772/intechopen.106489",abstract:"As inflammatory and oxidative stress are associated with cardiometabolic diseases, detection of abnormal fasting levels of inflammatory and oxidative biomarkers are indicative disease presence and may be too late for any preventive management. Metabolic flexibility refers to the ability of various metabolic processes to compensate for these acute changes and return all metabolites to baseline levels. By monitoring responses of key biomarkers to a standardized physiologic challenge, it is possible to assess the ability of the body to restore homeostasis, that is a measure of metabolic flexibility. Acute changes in lipoprotein-associated biomarkers of oxidative stress have been demonstrated following meal consumption. These include changes in circulating levels of oxidized low-density lipoproteins (LDL), levels of autoantibodies to malondialdehyde-modified LDL, as well as the oxidative susceptibility of isolated plasma LDL. These responses depend on the type and amount of dietary fats in the meal. Management with certain lipid-lowering drugs could also be shown to affect these meal-induced changes. However, plasma levels may be underestimated as we can demonstrate a spike in lipoprotein-associated biomarkers of oxidative stress resulting from the release oxidatively modified epitopes from the arterial wall by an intravenous bolus of heparin.",book:{id:"11671",title:"Importance of Oxidative Stress and Antioxidant System in Health and Disease",coverURL:"https://cdn.intechopen.com/books/images_new/11671.jpg"},signatures:"Ngoc-Anh Le"},{id:"83041",title:"Responses of Endoplasmic Reticulum to Plant Stress",slug:"responses-of-endoplasmic-reticulum-to-plant-stress",totalDownloads:0,totalDimensionsCites:null,doi:"10.5772/intechopen.106590",abstract:"Global climate change has resulted in alterations in the biotic and abiotic conditions of the planet. This has led to changes in the agricultural system resulting from reduced water availability, increased temperature increase in the population and occurrences of pests and diseases. Plants are adversely affected when they experience any stress retarding their growth, development and productivity. Endoplasmic Reticulum (ER) is an organelle that shows a tremendous response when subjected to stress conditions. Therefore, to explore and comprehend plants’ multidimensional interactions when subjected to stress conditions, an insight into the molecular stress signalling in the ER in response to the stress situation is discussed in this chapter.",book:{id:"11674",title:"Updates on Endoplasmic Reticulum",coverURL:"https://cdn.intechopen.com/books/images_new/11674.jpg"},signatures:"Vishwa Jyoti Baruah, Bhaswati Sarmah, Manny Saluja and Elizabeth H. Mahood"},{id:"83046",title:"Gene Expression and Transcriptome Sequencing: Basics, Analysis, Advances",slug:"gene-expression-and-transcriptome-sequencing-basics-analysis-advances",totalDownloads:2,totalDimensionsCites:0,doi:"10.5772/intechopen.105929",abstract:"Gene expression studies are extremely useful for understanding a broad range of biological, physiological, and molecular responses. The techniques for gene expression reflect differential patterns of gene regulation and have evolved with time from detecting one gene to many genes at a time laterally. Gene expression depends on the spatiotemporal expression in a particular tissue at a given time point and needs critical examination and interpretation. Transcriptome sequencing or RNA-seq using next-generation sequencing (short and long reads) is the most widely deployed technology for accurate quantification of gene expression. According to the biological aim of the experiment, replications, platform, and chemistries, propelling improvement has been demonstrated and documented using RNA-seq in plants, humans, animals, and clinical sciences with respect to gene expression of mRNA, small non-coding, long non-coding RNAs, alternative splice variations, isoform variations, gene fusions, single-nucleotide variants. Integrating transcriptome sequencing with other techniques such as chromatin immunoprecipitation, methylation, genome-wide association studies, manifests insights into genetic and epigenetic regulation. Epi-transcriptome including RNA methylation, modification, and alternative polyadenylation events can also be explored through long-read sequencing. In this chapter, we have presented an account of the basics of gene expression methods, transcriptome sequencing, and the various methodologies involved in the downstream analysis.",book:{id:"11349",title:"Gene Expression",coverURL:"https://cdn.intechopen.com/books/images_new/11349.jpg"},signatures:"Yogesh Shukla, Amol Phule, Harshvardhan Zala, Nakul D. Magar, Priya Shah, K. Harish, Tejas C. Bosamia, Kalyani M. Barbadikar, Maganti Sheshu Madhav, Satendra Kumar Mangrauthia, Chirravuri Naga Neeraja and Raman Meenakshi Sundaram"},{id:"83043",title:"Applications of CRISPR/Cas9 for Selective Sequencing and Clinical Diagnostics",slug:"applications-of-crispr-cas9-for-selective-sequencing-and-clinical-diagnostics",totalDownloads:6,totalDimensionsCites:0,doi:"10.5772/intechopen.106548",abstract:"In this chapter, we will discuss the applications of CRISPR/Cas9 in the context of clinical diagnostics. We will provide an overview of existing methods and their use cases in the diagnostic field. Special attention will be given to selective sequencing approaches using third-generation sequencing and PAM-site requirements. As target sequences in an AT-rich environment cannot easily be accessed by the commercially available SpCas9 due to rarity of NGG PAM-sites, new enzymes such as ScCas9 with PAM-site requirements of NNG will be highlighted. Original research on CRISPR/Cas9 systems to determine molecular glioma markers by enriching regions of interest will be discussed in the context of potential future applications in clinical diagnostics.",book:{id:"11804",title:"CRISPR Technology",coverURL:"https://cdn.intechopen.com/books/images_new/11804.jpg"},signatures:"Maximilian Evers, Björn Brändl, Franz-Josef Müller, Sönke Friedrichsen and Stephan Kolkenbrock"},{id:"82914",title:"Glance on the Critical Role of IL-23 Receptor Gene Variations in Inflammation-Induced Carcinogenesis",slug:"glance-on-the-critical-role-of-il-23-receptor-gene-variations-in-inflammation-induced-carcinogenesis",totalDownloads:15,totalDimensionsCites:0,doi:"10.5772/intechopen.105049",abstract:"In this chapter, we will discuss the importance of genetic variations in the IL-23 receptor (IL-23R) gene in driving the process of inflammation-induced carcinogenesis. By applying bladder cancer (BLC) as a model, we will focus on two contradictory genetic mutations within the receptor gene. The first one is enhanced by cancer and induces inflammation-induced carcinogenesis via up-regulating IL-23/IL-17 inflammatory axis. However, the other preventive one deregulates this inflammatory pathway by distorting the protein nature of the receptor, leading to block its binding affinity. During the process of carcinogenesis, cancer genetically inclines the balance towards the protumor, via over-expressing the IL-23R on the surfaces of immune-bearing cells, particularly tumor-associated monocytes (TAMs) and thus increasing the levels of pro-angiogenic cytokines IL-23 and IL-17.",book:{id:"11672",title:"Chemokines Updates",coverURL:"https://cdn.intechopen.com/books/images_new/11672.jpg"},signatures:"Mohammed El-Gedamy"},{id:"82259",title:"p53 Tumor Suppressor: Functional Regulation and Role in Gene Therapy",slug:"p53-tumor-suppressor-functional-regulation-and-role-in-gene-therapy",totalDownloads:7,totalDimensionsCites:0,doi:"10.5772/intechopen.105029",abstract:"p53, a homo-tetrameric protein found in mammalian cells, derives its name from the fact that it settles at around 53KDa position in SDS-PAGE, due to a “kink” in its structure. In its functional state, p53 forms a homo-tetramer and binds to the promoters of a wide array of genes. Binding of p53 downregulates the transcription of target genes. Most of the gene targets of p53 are involved in cell cycle progression, and therefore, any malfunctions associated with p53 have catastrophic consequences for the cell. The gene encoding for p53 known as TP53 is the most well-studied gene in the entire genome because of being the most highly mutated gene in all cancer types. It is due to this widely accepted and documented “cell protective feature” that p53 is generally referred to as “the guardian of the genome.” In this chapter, we will discuss the involvement of p53 in relation to carcinogenesis. We will also cover the major functions of p53 under normal conditions, major mutations of the TP53 gene, and their association with different forms of cancer.",book:{id:"10246",title:"P53 - A Guardian of the Genome and Beyond",coverURL:"https://cdn.intechopen.com/books/images_new/10246.jpg"},signatures:"Zeenat Farooq, Shahnawaz Wani, Vijay Avin BR, Rakesh Kochhar and Mumtaz Anwar"}],onlineFirstChaptersTotal:81},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:11,numberOfPublishedChapters:91,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:108,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:332,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:11,numberOfPublishedChapters:143,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:124,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:23,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:12,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"14",title:"Artificial Intelligence",doi:"10.5772/intechopen.79920",issn:"2633-1403",scope:"Artificial Intelligence (AI) is a rapidly developing multidisciplinary research area that aims to solve increasingly complex problems. 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He is currently appointed as the Voigt Chair in Data Science in the Department of Industrial Engineering, with a joint appointment as Professor in the Computer Science Division, Stellenbosch University. Prior to his appointment at Stellenbosch University, he has been at the University of Pretoria, Department of Computer Science (1998-2018), where he was appointed as South Africa Research Chair in Artifical Intelligence (2007-2018), the head of the Department of Computer Science (2008-2017), and Director of the Institute for Big Data and Data Science (2017-2018). 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He is a full professor of signal processing and pattern recognition and is head of the Signals and Communications Department at ULPGC, teaching from 2001 on subjects on signal processing and learning theory. His research lines are biometrics, biomedical signals and images, data mining, classification system, signal and image processing, machine learning, and environmental intelligence. He has researched in 52 international and Spanish research projects, some of them as head researcher. He is co-author of 4 books, co-editor of 27 proceedings books, guest editor for 8 JCR-ISI international journals, and up to 24 book chapters. He has over 450 papers published in international journals and conferences (81 of them indexed on JCR – ISI - Web of Science). He has published seven patents in the Spanish Patent and Trademark Office. He has been a supervisor on 8 Ph.D. theses (11 more are under supervision), and 130 master theses. He is the founder of The IEEE IWOBI conference series and the president of its Steering Committee, as well as the founder of both the InnoEducaTIC and APPIS conference series. He is an evaluator of project proposals for the European Union (H2020), Medical Research Council (MRC, UK), Spanish Government (ANECA, Spain), Research National Agency (ANR, France), DAAD (Germany), Argentinian Government, and the Colombian Institutions. He has been a reviewer in different indexed international journals (<70) and conferences (<250) since 2001. He has been a member of the IASTED Technical Committee on Image Processing from 2007 and a member of the IASTED Technical Committee on Artificial Intelligence and Expert Systems from 2011. \n\nHe has held the general chair position for the following: ACM-APPIS (2020, 2021), IEEE-IWOBI (2019, 2020 and 2020), A PPIS (2018, 2019), IEEE-IWOBI (2014, 2015, 2017, 2018), InnoEducaTIC (2014, 2017), IEEE-INES (2013), NoLISP (2011), JRBP (2012), and IEEE-ICCST (2005)\n\nHe is an associate editor of the Computational Intelligence and Neuroscience Journal (Hindawi – Q2 JCR-ISI). He was vice dean from 2004 to 2010 in the Higher Technical School of Telecommunication Engineers at ULPGC and the vice dean of Graduate and Postgraduate Studies from March 2013 to November 2017. He won the “Catedra Telefonica” Awards in Modality of Knowledge Transfer, 2017, 2018, and 2019 editions, and awards in Modality of COVID Research in 2020.\n\nPublic References:\nResearcher ID http://www.researcherid.com/rid/N-5967-2014\nORCID https://orcid.org/0000-0002-4621-2768 \nScopus Author ID https://www.scopus.com/authid/detail.uri?authorId=6602376272\nScholar Google https://scholar.google.es/citations?user=G1ks9nIAAAAJ&hl=en \nResearchGate https://www.researchgate.net/profile/Carlos_Travieso",institutionString:null,institution:{name:"University of Las Palmas de Gran Canaria",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"23",title:"Computational Neuroscience",coverUrl:"https://cdn.intechopen.com/series_topics/covers/23.jpg",isOpenForSubmission:!0,editor:{id:"14004",title:"Dr.",name:"Magnus",middleName:null,surname:"Johnsson",slug:"magnus-johnsson",fullName:"Magnus Johnsson",profilePictureURL:"https://mts.intechopen.com/storage/users/14004/images/system/14004.png",biography:"Dr Magnus Johnsson is a cross-disciplinary scientist, lecturer, scientific editor and AI/machine learning consultant from Sweden. \n\nHe is currently at Malmö University in Sweden, but also held positions at Lund University in Sweden and at Moscow Engineering Physics Institute. \nHe holds editorial positions at several international scientific journals and has served as a scientific editor for books and special journal issues. \nHis research interests are wide and include, but are not limited to, autonomous systems, computer modeling, artificial neural networks, artificial intelligence, cognitive neuroscience, cognitive robotics, cognitive architectures, cognitive aids and the philosophy of mind. \n\nDr. Johnsson has experience from working in the industry and he has a keen interest in the application of neural networks and artificial intelligence to fields like industry, finance, and medicine. \n\nWeb page: www.magnusjohnsson.se",institutionString:null,institution:{name:"Malmö University",institutionURL:null,country:{name:"Sweden"}}},editorTwo:null,editorThree:null},{id:"24",title:"Computer Vision",coverUrl:"https://cdn.intechopen.com/series_topics/covers/24.jpg",isOpenForSubmission:!0,editor:{id:"294154",title:"Prof.",name:"George",middleName:null,surname:"Papakostas",slug:"george-papakostas",fullName:"George Papakostas",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002hYaGbQAK/Profile_Picture_1624519712088",biography:"George A. 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He has (co)authored more than 150 publications in indexed journals, international conferences and book chapters, 1 book (in Greek), 3 edited books, and 5 journal special issues. His publications have more than 2100 citations with h-index 27 (GoogleScholar). His research interests include computer/machine vision, machine learning, pattern recognition, computational intelligence. \nDr. Papakostas served as a reviewer in numerous journals, as a program\ncommittee member in international conferences and he is a member of the IAENG, MIR Labs, EUCogIII, INSTICC and the Technical Chamber of Greece (TEE).",institutionString:null,institution:{name:"International Hellenic University",institutionURL:null,country:{name:"Greece"}}},editorTwo:null,editorThree:null},{id:"25",title:"Evolutionary Computation",coverUrl:"https://cdn.intechopen.com/series_topics/covers/25.jpg",isOpenForSubmission:!0,editor:{id:"136112",title:"Dr.",name:"Sebastian",middleName:null,surname:"Ventura Soto",slug:"sebastian-ventura-soto",fullName:"Sebastian Ventura Soto",profilePictureURL:"https://mts.intechopen.com/storage/users/136112/images/system/136112.png",biography:"Sebastian Ventura is a Spanish researcher, a full professor with the Department of Computer Science and Numerical Analysis, University of Córdoba. 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Ribeiro-Barros",profilePictureURL:"https://mts.intechopen.com/storage/users/171036/images/system/171036.jpg",institutionString:"University of Lisbon",institution:{name:"University of Lisbon",institutionURL:null,country:{name:"Portugal"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Sustainable Economy and Fair Society",value:91,count:1}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:1}],authors:{paginationCount:250,paginationItems:[{id:"274452",title:"Dr.",name:"Yousif",middleName:"Mohamed",surname:"Abdallah",slug:"yousif-abdallah",fullName:"Yousif Abdallah",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/274452/images/8324_n.jpg",biography:"I certainly enjoyed my experience in Radiotherapy and Nuclear Medicine, particularly it has been in different institutions and hospitals with different Medical Cultures and allocated resources. Radiotherapy and Nuclear Medicine Technology has always been my aspiration and my life. As years passed I accumulated a tremendous amount of skills and knowledge in Radiotherapy and Nuclear Medicine, Conventional Radiology, Radiation Protection, Bioinformatics Technology, PACS, Image processing, clinically and lecturing that will enable me to provide a valuable service to the community as a Researcher and Consultant in this field. My method of translating this into day to day in clinical practice is non-exhaustible and my habit of exchanging knowledge and expertise with others in those fields is the code and secret of success.",institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"313277",title:"Dr.",name:"Bartłomiej",middleName:null,surname:"Płaczek",slug:"bartlomiej-placzek",fullName:"Bartłomiej Płaczek",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/313277/images/system/313277.jpg",biography:"Bartłomiej Płaczek, MSc (2002), Ph.D. (2005), Habilitation (2016), is a professor at the University of Silesia, Institute of Computer Science, Poland, and an expert from the National Centre for Research and Development. His research interests include sensor networks, smart sensors, intelligent systems, and image processing with applications in healthcare and medicine. He is the author or co-author of more than seventy papers in peer-reviewed journals and conferences as well as the co-author of several books. He serves as a reviewer for many scientific journals, international conferences, and research foundations. Since 2010, Dr. Placzek has been a reviewer of grants and projects (including EU projects) in the field of information technologies.",institutionString:"University of Silesia",institution:{name:"University of Silesia",country:{name:"Poland"}}},{id:"35000",title:"Prof.",name:"Ulrich H.P",middleName:"H.P.",surname:"Fischer",slug:"ulrich-h.p-fischer",fullName:"Ulrich H.P Fischer",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/35000/images/3052_n.jpg",biography:"Academic and Professional Background\nUlrich H. P. has Diploma and PhD degrees in Physics from the Free University Berlin, Germany. He has been working on research positions in the Heinrich-Hertz-Institute in Germany. Several international research projects has been performed with European partners from France, Netherlands, Norway and the UK. He is currently Professor of Communications Systems at the Harz University of Applied Sciences, Germany.\n\nPublications and Publishing\nHe has edited one book, a special interest book about ‘Optoelectronic Packaging’ (VDE, Berlin, Germany), and has published over 100 papers and is owner of several international patents for WDM over POF key elements.\n\nKey Research and Consulting Interests\nUlrich’s research activity has always been related to Spectroscopy and Optical Communications Technology. Specific current interests include the validation of complex instruments, and the application of VR technology to the development and testing of measurement systems. He has been reviewer for several publications of the Optical Society of America\\'s including Photonics Technology Letters and Applied Optics.\n\nPersonal Interests\nThese include motor cycling in a very relaxed manner and performing martial arts.",institutionString:null,institution:{name:"Charité",country:{name:"Germany"}}},{id:"341622",title:"Ph.D.",name:"Eduardo",middleName:null,surname:"Rojas Alvarez",slug:"eduardo-rojas-alvarez",fullName:"Eduardo Rojas Alvarez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/341622/images/15892_n.jpg",biography:null,institutionString:null,institution:{name:"University of Cuenca",country:{name:"Ecuador"}}},{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/215610/images/system/215610.jpeg",biography:"Muhammad Sarfraz is a professor in the Department of Information Science, Kuwait University. His research interests include computer graphics, computer vision, image processing, machine learning, pattern recognition, soft computing, data science, intelligent systems, information technology, and information systems. Prof. Sarfraz has been a keynote/invited speaker on various platforms around the globe. He has advised various students for their MSc and Ph.D. theses. He has published more than 400 publications as books, journal articles, and conference papers. He is a member of various professional societies and a chair and member of the International Advisory Committees and Organizing Committees of various international conferences. Prof. Sarfraz is also an editor-in-chief and editor of various international journals.",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"32650",title:"Prof.",name:"Lukas",middleName:"Willem",surname:"Snyman",slug:"lukas-snyman",fullName:"Lukas Snyman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/32650/images/4136_n.jpg",biography:"Lukas Willem Snyman received his basic education at primary and high schools in South Africa, Eastern Cape. He enrolled at today's Nelson Metropolitan University and graduated from this university with a BSc in Physics and Mathematics, B.Sc Honors in Physics, MSc in Semiconductor Physics, and a Ph.D. in Semiconductor Physics in 1987. After his studies, he chose an academic career and devoted his energy to the teaching of physics to first, second, and third-year students. After positions as a lecturer at the University of Port Elizabeth, he accepted a position as Associate Professor at the University of Pretoria, South Africa.\r\n\r\nIn 1992, he motivates the concept of 'television and computer-based education” as means to reach large student numbers with only the best of teaching expertise and publishes an article on the concept in the SA Journal of Higher Education of 1993 (and later in 2003). The University of Pretoria subsequently approved a series of test projects on the concept with outreach to Mamelodi and Eerste Rust in 1993. In 1994, the University established a 'Unit for Telematic Education ' as a support section for multiple faculties at the University of Pretoria. In subsequent years, the concept of 'telematic education” subsequently becomes well established in academic circles in South Africa, grew in popularity, and is adopted by many universities and colleges throughout South Africa as a medium of enhancing education and training, as a method to reaching out to far out communities, and as a means to enhance study from the home environment.\r\n\r\nProfessor Snyman in subsequent years pursued research in semiconductor physics, semiconductor devices, microelectronics, and optoelectronics.\r\n\r\nIn 2000 he joined the TUT as a full professor. Here served for a period as head of the Department of Electronic Engineering. Here he makes contributions to solar energy development, microwave and optoelectronic device development, silicon photonics, as well as contributions to new mobile telecommunication systems and network planning in SA.\r\n\r\nCurrently, he teaches electronics and telecommunications at the TUT to audiences ranging from first-year students to Ph.D. level.\r\n\r\nFor his research in the field of 'Silicon Photonics” since 1990, he has published (as author and co-author) about thirty internationally reviewed articles in scientific journals, contributed to more than forty international conferences, about 25 South African provisional patents (as inventor and co-inventor), 8 PCT international patent applications until now. Of these, two USA patents applications, two European Patents, two Korean patents, and ten SA patents have been granted. A further 4 USA patents, 5 European patents, 3 Korean patents, 3 Chinese patents, and 3 Japanese patents are currently under consideration.\r\n\r\nRecently he has also published an extensive scholarly chapter in an internet open access book on 'Integrating Microphotonic Systems and MOEMS into standard Silicon CMOS Integrated circuitry”.\r\n\r\nFurthermore, Professor Snyman recently steered a new initiative at the TUT by introducing a 'Laboratory for Innovative Electronic Systems ' at the Department of Electrical Engineering. The model of this laboratory or center is to primarily combine outputs as achieved by high-level research with lower-level system development and entrepreneurship in a technical university environment. Students are allocated to projects at different levels with PhDs and Master students allocated to the generation of new knowledge and new technologies, while students at the diploma and Baccalaureus level are allocated to electronic systems development with a direct and a near application for application in industry or the commercial and public sectors in South Africa.\r\n\r\nProfessor Snyman received the WIRSAM Award of 1983 and the WIRSAM Award in 1985 in South Africa for best research papers by a young scientist at two international conferences on electron microscopy in South Africa. He subsequently received the SA Microelectronics Award for the best dissertation emanating from studies executed at a South African university in the field of Physics and Microelectronics in South Africa in 1987. In October of 2011, Professor Snyman received the prestigious Institutional Award for 'Innovator of the Year” for 2010 at the Tshwane University of Technology, South Africa. This award was based on the number of patents recognized and granted by local and international institutions as well as for his contributions concerning innovation at the TUT.",institutionString:null,institution:{name:"University of South Africa",country:{name:"South Africa"}}},{id:"317279",title:"Mr.",name:"Ali",middleName:"Usama",surname:"Syed",slug:"ali-syed",fullName:"Ali Syed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/317279/images/16024_n.png",biography:"A creative, talented, and innovative young professional who is dedicated, well organized, and capable research fellow with two years of experience in graduate-level research, published in engineering journals and book, with related expertise in Bio-robotics, equally passionate about the aesthetics of the mechanical and electronic system, obtained expertise in the use of MS Office, MATLAB, SolidWorks, LabVIEW, Proteus, Fusion 360, having a grasp on python, C++ and assembly language, possess proven ability in acquiring research grants, previous appointments with social and educational societies with experience in administration, current affiliations with IEEE and Web of Science, a confident presenter at conferences and teacher in classrooms, able to explain complex information to audiences of all levels.",institutionString:null,institution:{name:"Air University",country:{name:"Pakistan"}}},{id:"75526",title:"Ph.D.",name:"Zihni Onur",middleName:null,surname:"Uygun",slug:"zihni-onur-uygun",fullName:"Zihni Onur Uygun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/75526/images/12_n.jpg",biography:"My undergraduate education and my Master of Science educations at Ege University and at Çanakkale Onsekiz Mart University have given me a firm foundation in Biochemistry, Analytical Chemistry, Biosensors, Bioelectronics, Physical Chemistry and Medicine. After obtaining my degree as a MSc in analytical chemistry, I started working as a research assistant in Ege University Medical Faculty in 2014. In parallel, I enrolled to the MSc program at the Department of Medical Biochemistry at Ege University to gain deeper knowledge on medical and biochemical sciences as well as clinical chemistry in 2014. In my PhD I deeply researched on biosensors and bioelectronics and finished in 2020. Now I have eleven SCI-Expanded Index published papers, 6 international book chapters, referee assignments for different SCIE journals, one international patent pending, several international awards, projects and bursaries. In parallel to my research assistant position at Ege University Medical Faculty, Department of Medical Biochemistry, in April 2016, I also founded a Start-Up Company (Denosens Biotechnology LTD) by the support of The Scientific and Technological Research Council of Turkey. Currently, I am also working as a CEO in Denosens Biotechnology. The main purposes of the company, which carries out R&D as a research center, are to develop new generation biosensors and sensors for both point-of-care diagnostics; such as glucose, lactate, cholesterol and cancer biomarker detections. My specific experimental and instrumental skills are Biochemistry, Biosensor, Analytical Chemistry, Electrochemistry, Mobile phone based point-of-care diagnostic device, POCTs and Patient interface designs, HPLC, Tandem Mass Spectrometry, Spectrophotometry, ELISA.",institutionString:null,institution:{name:"Ege University",country:{name:"Turkey"}}},{id:"267434",title:"Dr.",name:"Rohit",middleName:null,surname:"Raja",slug:"rohit-raja",fullName:"Rohit Raja",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/267434/images/system/267434.jpg",biography:"Dr. Rohit Raja received Ph.D. in Computer Science and Engineering from Dr. CVRAMAN University in 2016. His main research interest includes Face recognition and Identification, Digital Image Processing, Signal Processing, and Networking. Presently he is working as Associate Professor in IT Department, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur (CG), India. He has authored several Journal and Conference Papers. He has good Academics & Research experience in various areas of CSE and IT. He has filed and successfully published 27 Patents. He has received many time invitations to be a Guest at IEEE Conferences. He has published 100 research papers in various International/National Journals (including IEEE, Springer, etc.) and Proceedings of the reputed International/ National Conferences (including Springer and IEEE). He has been nominated to the board of editors/reviewers of many peer-reviewed and refereed Journals (including IEEE, Springer).",institutionString:"Guru Ghasidas Vishwavidyalaya",institution:{name:"Guru Ghasidas Vishwavidyalaya",country:{name:"India"}}},{id:"246502",title:"Dr.",name:"Jaya T.",middleName:"T",surname:"Varkey",slug:"jaya-t.-varkey",fullName:"Jaya T. Varkey",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246502/images/11160_n.jpg",biography:"Jaya T. Varkey, PhD, graduated with a degree in Chemistry from Cochin University of Science and Technology, Kerala, India. She obtained a PhD in Chemistry from the School of Chemical Sciences, Mahatma Gandhi University, Kerala, India, and completed a post-doctoral fellowship at the University of Minnesota, USA. She is a research guide at Mahatma Gandhi University and Associate Professor in Chemistry, St. Teresa’s College, Kochi, Kerala, India.\nDr. Varkey received a National Young Scientist award from the Indian Science Congress (1995), a UGC Research award (2016–2018), an Indian National Science Academy (INSA) Visiting Scientist award (2018–2019), and a Best Innovative Faculty award from the All India Association for Christian Higher Education (AIACHE) (2019). She Hashas received the Sr. Mary Cecil prize for best research paper three times. She was also awarded a start-up to develop a tea bag water filter. \nDr. Varkey has published two international books and twenty-seven international journal publications. She is an editorial board member for five international journals.",institutionString:"St. Teresa’s College",institution:null},{id:"250668",title:"Dr.",name:"Ali",middleName:null,surname:"Nabipour Chakoli",slug:"ali-nabipour-chakoli",fullName:"Ali Nabipour Chakoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/250668/images/system/250668.jpg",biography:"Academic Qualification:\r\n•\tPhD in Materials Physics and Chemistry, From: Sep. 2006, to: Sep. 2010, School of Materials Science and Engineering, Harbin Institute of Technology, Thesis: Structure and Shape Memory Effect of Functionalized MWCNTs/poly (L-lactide-co-ε-caprolactone) Nanocomposites. Supervisor: Prof. Wei Cai,\r\n•\tM.Sc in Applied Physics, From: 1996, to: 1998, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Determination of Boron in Micro alloy Steels with solid state nuclear track detectors by neutron induced auto radiography, Supervisors: Dr. M. Hosseini Ashrafi and Dr. A. Hosseini.\r\n•\tB.Sc. in Applied Physics, From: 1991, to: 1996, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Design of shielding for Am-Be neutron sources for In Vivo neutron activation analysis, Supervisor: Dr. M. Hosseini Ashrafi.\r\n\r\nResearch Experiences:\r\n1.\tNanomaterials, Carbon Nanotubes, Graphene: Synthesis, Functionalization and Characterization,\r\n2.\tMWCNTs/Polymer Composites: Fabrication and Characterization, \r\n3.\tShape Memory Polymers, Biodegradable Polymers, ORC, Collagen,\r\n4.\tMaterials Analysis and Characterizations: TEM, SEM, XPS, FT-IR, Raman, DSC, DMA, TGA, XRD, GPC, Fluoroscopy, \r\n5.\tInteraction of Radiation with Mater, Nuclear Safety and Security, NDT(RT),\r\n6.\tRadiation Detectors, Calibration (SSDL),\r\n7.\tCompleted IAEA e-learning Courses:\r\nNuclear Security (15 Modules),\r\nNuclear Safety:\r\nTSA 2: Regulatory Protection in Occupational Exposure,\r\nTips & Tricks: Radiation Protection in Radiography,\r\nSafety and Quality in Radiotherapy,\r\nCourse on Sealed Radioactive Sources,\r\nCourse on Fundamentals of Environmental Remediation,\r\nCourse on Planning for Environmental Remediation,\r\nKnowledge Management Orientation Course,\r\nFood Irradiation - Technology, Applications and Good Practices,\r\nEmployment:\r\nFrom 2010 to now: Academic staff, Nuclear Science and Technology Research Institute, Kargar Shomali, Tehran, Iran, P.O. Box: 14395-836.\r\nFrom 1997 to 2006: Expert of Materials Analysis and Characterization. Research Center of Agriculture and Medicine. Rajaeeshahr, Karaj, Iran, P. O. Box: 31585-498.",institutionString:"Atomic Energy Organization of Iran",institution:{name:"Atomic Energy Organization of Iran",country:{name:"Iran"}}},{id:"248279",title:"Dr.",name:"Monika",middleName:"Elzbieta",surname:"Machoy",slug:"monika-machoy",fullName:"Monika Machoy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248279/images/system/248279.jpeg",biography:"Monika Elżbieta Machoy, MD, graduated with distinction from the Faculty of Medicine and Dentistry at the Pomeranian Medical University in 2009, defended her PhD thesis with summa cum laude in 2016 and is currently employed as a researcher at the Department of Orthodontics of the Pomeranian Medical University. She expanded her professional knowledge during a one-year scholarship program at the Ernst Moritz Arndt University in Greifswald, Germany and during a three-year internship at the Technical University in Dresden, Germany. She has been a speaker at numerous orthodontic conferences, among others, American Association of Orthodontics, European Orthodontic Symposium and numerous conferences of the Polish Orthodontic Society. She conducts research focusing on the effect of orthodontic treatment on dental and periodontal tissues and the causes of pain in orthodontic patients.",institutionString:"Pomeranian Medical University",institution:{name:"Pomeranian Medical University",country:{name:"Poland"}}},{id:"252743",title:"Prof.",name:"Aswini",middleName:"Kumar",surname:"Kar",slug:"aswini-kar",fullName:"Aswini Kar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252743/images/10381_n.jpg",biography:"uploaded in cv",institutionString:null,institution:{name:"KIIT University",country:{name:"India"}}},{id:"204256",title:"Dr.",name:"Anil",middleName:"Kumar",surname:"Kumar Sahu",slug:"anil-kumar-sahu",fullName:"Anil Kumar Sahu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204256/images/14201_n.jpg",biography:"I have nearly 11 years of research and teaching experience. I have done my master degree from University Institute of Pharmacy, Pt. Ravi Shankar Shukla University, Raipur, Chhattisgarh India. I have published 16 review and research articles in international and national journals and published 4 chapters in IntechOpen, the world’s leading publisher of Open access books. I have presented many papers at national and international conferences. I have received research award from Indian Drug Manufacturers Association in year 2015. My research interest extends from novel lymphatic drug delivery systems, oral delivery system for herbal bioactive to formulation optimization.",institutionString:null,institution:{name:"Chhattisgarh Swami Vivekanand Technical University",country:{name:"India"}}},{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",biography:"An assistant professor at Department of Biomedical Computer Systems, at Institute of Computer Science, Silesian University in Katowice. Scientific interests: computer analysis and processing of images, biomedical images, databases and programming languages. He is an author and co-author of scientific publications covering analysis and processing of biomedical images and development of database systems.",institutionString:"University of Silesia",institution:{name:"University of Silesia",country:{name:"Poland"}}},{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",biography:"Dr. Hadi Mohammadi is a biomedical engineer with hands-on experience in the design and development of many engineering structures and medical devices through various projects that he has been involved in over the past twenty years. Dr. Mohammadi received his BSc. and MSc. degrees in Mechanical Engineering from Sharif University of Technology, Tehran, Iran, and his PhD. degree in Biomedical Engineering (biomaterials) from the University of Western Ontario. He was a postdoctoral trainee for almost four years at University of Calgary and Harvard Medical School. He is an industry innovator having created the technology to produce lifelike synthetic platforms that can be used for the simulation of almost all cardiovascular reconstructive surgeries. He’s been heavily involved in the design and development of cardiovascular devices and technology for the past 10 years. He is currently an Assistant Professor with the University of British Colombia, Canada.",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",country:{name:"Canada"}}},{id:"254463",title:"Prof.",name:"Haisheng",middleName:null,surname:"Yang",slug:"haisheng-yang",fullName:"Haisheng Yang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/254463/images/system/254463.jpeg",biography:"Haisheng Yang, Ph.D., Professor and Director of the Department of Biomedical Engineering, College of Life Science and Bioengineering, Beijing University of Technology. He received his Ph.D. degree in Mechanics/Biomechanics from Harbin Institute of Technology (jointly with University of California, Berkeley). Afterwards, he worked as a Postdoctoral Research Associate in the Purdue Musculoskeletal Biology and Mechanics Lab at the Department of Basic Medical Sciences, Purdue University, USA. He also conducted research in the Research Centre of Shriners Hospitals for Children-Canada at McGill University, Canada. Dr. Yang has over 10 years research experience in orthopaedic biomechanics and mechanobiology of bone adaptation and regeneration. He earned an award from Beijing Overseas Talents Aggregation program in 2017 and serves as Beijing Distinguished Professor.",institutionString:null,institution:{name:"Beijing University of Technology",country:{name:"China"}}},{id:"89721",title:"Dr.",name:"Mehmet",middleName:"Cuneyt",surname:"Ozmen",slug:"mehmet-ozmen",fullName:"Mehmet Ozmen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/89721/images/7289_n.jpg",biography:null,institutionString:null,institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"265335",title:"Mr.",name:"Stefan",middleName:"Radnev",surname:"Stefanov",slug:"stefan-stefanov",fullName:"Stefan Stefanov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/265335/images/7562_n.jpg",biography:null,institutionString:null,institution:{name:"Medical University Plovdiv",country:{name:"Bulgaria"}}},{id:"242893",title:"Ph.D. Student",name:"Joaquim",middleName:null,surname:"De Moura",slug:"joaquim-de-moura",fullName:"Joaquim De Moura",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/242893/images/7133_n.jpg",biography:"Joaquim de Moura received his degree in Computer Engineering in 2014 from the University of A Coruña (Spain). In 2016, he received his M.Sc degree in Computer Engineering from the same university. He is currently pursuing his Ph.D degree in Computer Science in a collaborative project between ophthalmology centers in Galicia and the University of A Coruña. His research interests include computer vision, machine learning algorithms and analysis and medical imaging processing of various kinds.",institutionString:null,institution:{name:"University of A Coruña",country:{name:"Spain"}}},{id:"294334",title:"B.Sc.",name:"Marc",middleName:null,surname:"Bruggeman",slug:"marc-bruggeman",fullName:"Marc Bruggeman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/294334/images/8242_n.jpg",biography:"Chemical engineer graduate, with a passion for material science and specific interest in polymers - their near infinite applications intrigue me. \n\nI plan to continue my scientific career in the field of polymeric biomaterials as I am fascinated by intelligent, bioactive and biomimetic materials for use in both consumer and medical applications.",institutionString:null,institution:null},{id:"255757",title:"Dr.",name:"Igor",middleName:"Victorovich",surname:"Lakhno",slug:"igor-lakhno",fullName:"Igor Lakhno",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255757/images/system/255757.jpg",biography:"Igor Victorovich Lakhno was born in 1971 in Kharkiv (Ukraine). \nMD – 1994, Kharkiv National Medical Univesity.\nOb&Gyn; – 1997, master courses in Kharkiv Medical Academy of Postgraduate Education.\nPh.D. – 1999, Kharkiv National Medical Univesity.\nDSC – 2019, PL Shupik National Academy of Postgraduate Education \nProfessor – 2021, Department of Obstetrics and Gynecology of VN Karazin Kharkiv National University\nHead of Department – 2021, Department of Perinatology, Obstetrics and gynecology of Kharkiv Medical Academy of Postgraduate Education\nIgor Lakhno has been graduated from international training courses on reproductive medicine and family planning held at Debrecen University (Hungary) in 1997. Since 1998 Lakhno Igor has worked as an associate professor in the department of obstetrics and gynecology of VN Karazin National University and an associate professor of the perinatology, obstetrics, and gynecology department of Kharkiv Medical Academy of Postgraduate Education. Since June 2019 he’s been a professor in the department of obstetrics and gynecology of VN Karazin National University and a professor of the perinatology, obstetrics, and gynecology department. He’s affiliated with Kharkiv Medical Academy of Postgraduate Education as a Head of Department from November 2021. Igor Lakhno has participated in several international projects on fetal non-invasive electrocardiography (with Dr. J. A. Behar (Technion), Prof. D. Hoyer (Jena University), and José Alejandro Díaz Méndez (National Institute of Astrophysics, Optics, and Electronics, Mexico). He’s an author of about 200 printed works and there are 31 of them in Scopus or Web of Science databases. Igor Lakhno is a member of the Editorial Board of Reproductive Health of Woman, Emergency Medicine, and Technology Transfer Innovative Solutions in Medicine (Estonia). He is a medical Editor of “Z turbotoyu pro zhinku”. Igor Lakhno is a reviewer of the Journal of Obstetrics and Gynaecology (Taylor and Francis), British Journal of Obstetrics and Gynecology (Wiley), Informatics in Medicine Unlocked (Elsevier), The Journal of Obstetrics and Gynecology Research (Wiley), Endocrine, Metabolic & Immune Disorders-Drug Targets (Bentham Open), The Open Biomedical Engineering Journal (Bentham Open), etc. He’s defended a dissertation for a DSc degree “Pre-eclampsia: prediction, prevention, and treatment”. Three years ago Igor Lakhno has participated in a training course on innovative technologies in medical education at Lublin Medical University (Poland). Lakhno Igor has participated as a speaker in several international conferences and congresses (International Conference on Biological Oscillations April 10th-14th 2016, Lancaster, UK, The 9th conference of the European Study Group on Cardiovascular Oscillations). His main scientific interests: are obstetrics, women’s health, fetal medicine, and cardiovascular medicine. \nIgor Lakhno is a consultant at Kharkiv municipal perinatal center. He’s graduated from training courses on endoscopy in gynecology. He has 28 years of practical experience in the field.",institutionString:null,institution:null},{id:"244950",title:"Dr.",name:"Salvatore",middleName:null,surname:"Di Lauro",slug:"salvatore-di-lauro",fullName:"Salvatore Di Lauro",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0030O00002bSF1HQAW/ProfilePicture%202021-12-20%2014%3A54%3A14.482",biography:"Name:\n\tSALVATORE DI LAURO\nAddress:\n\tHospital Clínico Universitario Valladolid\nAvda Ramón y Cajal 3\n47005, Valladolid\nSpain\nPhone number: \nFax\nE-mail:\n\t+34 983420000 ext 292\n+34 983420084\nsadilauro@live.it\nDate and place of Birth:\nID Number\nMedical Licence \nLanguages\t09-05-1985. Villaricca (Italy)\n\nY1281863H\n474707061\nItalian (native language)\nSpanish (read, written, spoken)\nEnglish (read, written, spoken)\nPortuguese (read, spoken)\nFrench (read)\n\t\t\nCurrent position (title and company)\tDate (Year)\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. Private practise.\t2017-today\n\n2019-today\n\t\n\t\nEducation (High school, university and postgraduate training > 3 months)\tDate (Year)\nDegree in Medicine and Surgery. University of Neaples 'Federico II”\nResident in Opthalmology. Hospital Clinico Universitario Valladolid\nMaster in Vitreo-Retina. IOBA. University of Valladolid\nFellow of the European Board of Ophthalmology. Paris\nMaster in Research in Ophthalmology. University of Valladolid\t2003-2009\n2012-2016\n2016-2017\n2016\n2012-2013\n\t\nEmployments (company and positions)\tDate (Year)\nResident in Ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl.\nFellow in Vitreo-Retina. IOBA. University of Valladolid\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. \n\t2012-2016\n2016-2017\n2017-today\n\n2019-Today\n\n\n\t\nClinical Research Experience (tasks and role)\tDate (Year)\nAssociated investigator\n\n' FIS PI20/00740: DESARROLLO DE UNA CALCULADORA DE RIESGO DE\nAPARICION DE RETINOPATIA DIABETICA BASADA EN TECNICAS DE IMAGEN MULTIMODAL EN PACIENTES DIABETICOS TIPO 1. Grant by: Ministerio de Ciencia e Innovacion \n\n' (BIO/VA23/14) Estudio clínico multicéntrico y prospectivo para validar dos\nbiomarcadores ubicados en los genes p53 y MDM2 en la predicción de los resultados funcionales de la cirugía del desprendimiento de retina regmatógeno. Grant by: Gerencia Regional de Salud de la Junta de Castilla y León.\n' Estudio multicéntrico, aleatorizado, con enmascaramiento doble, en 2 grupos\nparalelos y de 52 semanas de duración para comparar la eficacia, seguridad e inmunogenicidad de SOK583A1 respecto a Eylea® en pacientes con degeneración macular neovascular asociada a la edad' (CSOK583A12301; N.EUDRA: 2019-004838-41; FASE III). Grant by Hexal AG\n\n' Estudio de fase III, aleatorizado, doble ciego, con grupos paralelos, multicéntrico para comparar la eficacia y la seguridad de QL1205 frente a Lucentis® en pacientes con degeneración macular neovascular asociada a la edad. (EUDRACT: 2018-004486-13). Grant by Qilu Pharmaceutical Co\n\n' Estudio NEUTON: Ensayo clinico en fase IV para evaluar la eficacia de aflibercept en pacientes Naive con Edema MacUlar secundario a Oclusion de Vena CenTral de la Retina (OVCR) en regimen de tratamientO iNdividualizado Treat and Extend (TAE)”, (2014-000975-21). Grant by Fundacion Retinaplus\n\n' Evaluación de la seguridad y bioactividad de anillos de tensión capsular en conejo. Proyecto Procusens. Grant by AJL, S.A.\n\n'Estudio epidemiológico, prospectivo, multicéntrico y abierto\\npara valorar la frecuencia de la conjuntivitis adenovírica diagnosticada mediante el test AdenoPlus®\\nTest en pacientes enfermos de conjuntivitis aguda”\\n. National, multicenter study. Grant by: NICOX.\n\nEuropean multicentric trial: 'Evaluation of clinical outcomes following the use of Systane Hydration in patients with dry eye”. Study Phase 4. Grant by: Alcon Labs'\n\nVLPs Injection and Activation in a Rabbit Model of Uveal Melanoma. Grant by Aura Bioscience\n\nUpdating and characterization of a rabbit model of uveal melanoma. Grant by Aura Bioscience\n\nEnsayo clínico en fase IV para evaluar las variantes genéticas de la vía del VEGF como biomarcadores de eficacia del tratamiento con aflibercept en pacientes con degeneración macular asociada a la edad (DMAE) neovascular. Estudio BIOIMAGE. IMO-AFLI-2013-01\n\nEstudio In-Eye:Ensayo clínico en fase IV, abierto, aleatorizado, de 2 brazos,\nmulticçentrico y de 12 meses de duración, para evaluar la eficacia y seguridad de un régimen de PRN flexible individualizado de 'esperar y extender' versus un régimen PRN según criterios de estabilización mediante evaluaciones mensuales de inyecciones intravítreas de ranibizumab 0,5 mg en pacientes naive con neovascularización coriodea secunaria a la degeneración macular relacionada con la edad. CP: CRFB002AES03T\n\nTREND: Estudio Fase IIIb multicéntrico, randomizado, de 12 meses de\nseguimiento con evaluador de la agudeza visual enmascarado, para evaluar la eficacia y la seguridad de ranibizumab 0.5mg en un régimen de tratar y extender comparado con un régimen mensual, en pacientes con degeneración macular neovascular asociada a la edad. CP: CRFB002A2411 Código Eudra CT:\n2013-002626-23\n\n\n\nPublications\t\n\n2021\n\n\n\n\n2015\n\n\n\n\n2021\n\n\n\n\n\n2021\n\n\n\n\n2015\n\n\n\n\n2015\n\n\n2014\n\n\n\n\n2015-16\n\n\n\n2015\n\n\n2014\n\n\n2014\n\n\n\n\n2014\n\n\n\n\n\n\n\n2014\n\nJose Carlos Pastor; Jimena Rojas; Salvador Pastor-Idoate; Salvatore Di Lauro; Lucia Gonzalez-Buendia; Santiago Delgado-Tirado. Proliferative vitreoretinopathy: A new concept of disease pathogenesis and practical\nconsequences. Progress in Retinal and Eye Research. 51, pp. 125 - 155. 03/2016. DOI: 10.1016/j.preteyeres.2015.07.005\n\n\nLabrador-Velandia S; Alonso-Alonso ML; Di Lauro S; García-Gutierrez MT; Srivastava GK; Pastor JC; Fernandez-Bueno I. Mesenchymal stem cells provide paracrine neuroprotective resources that delay degeneration of co-cultured organotypic neuroretinal cultures.Experimental Eye Research. 185, 17/05/2019. DOI: 10.1016/j.exer.2019.05.011\n\nSalvatore Di Lauro; Maria Teresa Garcia Gutierrez; Ivan Fernandez Bueno. Quantification of pigment epithelium-derived factor (PEDF) in an ex vivo coculture of retinal pigment epithelium cells and neuroretina.\nJournal of Allbiosolution. 2019. ISSN 2605-3535\n\nSonia Labrador Velandia; Salvatore Di Lauro; Alonso-Alonso ML; Tabera Bartolomé S; Srivastava GK; Pastor JC; Fernandez-Bueno I. Biocompatibility of intravitreal injection of human mesenchymal stem cells in immunocompetent rabbits. Graefe's archive for clinical and experimental ophthalmology. 256 - 1, pp. 125 - 134. 01/2018. DOI: 10.1007/s00417-017-3842-3\n\n\nSalvatore Di Lauro, David Rodriguez-Crespo, Manuel J Gayoso, Maria T Garcia-Gutierrez, J Carlos Pastor, Girish K Srivastava, Ivan Fernandez-Bueno. A novel coculture model of porcine central neuroretina explants and retinal pigment epithelium cells. Molecular Vision. 2016 - 22, pp. 243 - 253. 01/2016.\n\nSalvatore Di Lauro. Classifications for Proliferative Vitreoretinopathy ({PVR}): An Analysis of Their Use in Publications over the Last 15 Years. Journal of Ophthalmology. 2016, pp. 1 - 6. 01/2016. DOI: 10.1155/2016/7807596\n\nSalvatore Di Lauro; Rosa Maria Coco; Rosa Maria Sanabria; Enrique Rodriguez de la Rua; Jose Carlos Pastor. Loss of Visual Acuity after Successful Surgery for Macula-On Rhegmatogenous Retinal Detachment in a Prospective Multicentre Study. Journal of Ophthalmology. 2015:821864, 2015. DOI: 10.1155/2015/821864\n\nIvan Fernandez-Bueno; Salvatore Di Lauro; Ivan Alvarez; Jose Carlos Lopez; Maria Teresa Garcia-Gutierrez; Itziar Fernandez; Eva Larra; Jose Carlos Pastor. Safety and Biocompatibility of a New High-Density Polyethylene-Based\nSpherical Integrated Porous Orbital Implant: An Experimental Study in Rabbits. Journal of Ophthalmology. 2015:904096, 2015. DOI: 10.1155/2015/904096\n\nPastor JC; Pastor-Idoate S; Rodríguez-Hernandez I; Rojas J; Fernandez I; Gonzalez-Buendia L; Di Lauro S; Gonzalez-Sarmiento R. Genetics of PVR and RD. Ophthalmologica. 232 - Suppl 1, pp. 28 - 29. 2014\n\nRodriguez-Crespo D; Di Lauro S; Singh AK; Garcia-Gutierrez MT; Garrosa M; Pastor JC; Fernandez-Bueno I; Srivastava GK. Triple-layered mixed co-culture model of RPE cells with neuroretina for evaluating the neuroprotective effects of adipose-MSCs. Cell Tissue Res. 358 - 3, pp. 705 - 716. 2014.\nDOI: 10.1007/s00441-014-1987-5\n\nCarlo De Werra; Salvatore Condurro; Salvatore Tramontano; Mario Perone; Ivana Donzelli; Salvatore Di Lauro; Massimo Di Giuseppe; Rosa Di Micco; Annalisa Pascariello; Antonio Pastore; Giorgio Diamantis; Giuseppe Galloro. Hydatid disease of the liver: thirty years of surgical experience.Chirurgia italiana. 59 - 5, pp. 611 - 636.\n(Italia): 2007. ISSN 0009-4773\n\nChapters in books\n\t\n' Salvador Pastor Idoate; Salvatore Di Lauro; Jose Carlos Pastor Jimeno. PVR: Pathogenesis, Histopathology and Classification. Proliferative Vitreoretinopathy with Small Gauge Vitrectomy. Springer, 2018. ISBN 978-3-319-78445-8\nDOI: 10.1007/978-3-319-78446-5_2. \n\n' Salvatore Di Lauro; Maria Isabel Lopez Galvez. Quistes vítreos en una mujer joven. Problemas diagnósticos en patología retinocoroidea. Sociedad Española de Retina-Vitreo. 2018.\n\n' Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor Jimeno. iOCT in PVR management. OCT Applications in Opthalmology. pp. 1 - 8. INTECH, 2018. DOI: 10.5772/intechopen.78774.\n\n' Rosa Coco Martin; Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor. amponadores, manipuladores y tinciones en la cirugía del traumatismo ocular.Trauma Ocular. Ponencia de la SEO 2018..\n\n' LOPEZ GALVEZ; DI LAURO; CRESPO. OCT angiografia y complicaciones retinianas de la diabetes. PONENCIA SEO 2021, CAPITULO 20. (España): 2021.\n\n' Múltiples desprendimientos neurosensoriales bilaterales en paciente joven. Enfermedades Degenerativas De Retina Y Coroides. SERV 04/2016. \n' González-Buendía L; Di Lauro S; Pastor-Idoate S; Pastor Jimeno JC. Vitreorretinopatía proliferante (VRP) e inflamación: LA INFLAMACIÓN in «INMUNOMODULADORES Y ANTIINFLAMATORIOS: MÁS ALLÁ DE LOS CORTICOIDES. RELACION DE PONENCIAS DE LA SOCIEDAD ESPAÑOLA DE OFTALMOLOGIA. 10/2014.",institutionString:null,institution:null},{id:"243698",title:"Dr.",name:"Xiaogang",middleName:null,surname:"Wang",slug:"xiaogang-wang",fullName:"Xiaogang Wang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243698/images/system/243698.png",biography:"Dr. Xiaogang Wang, a faculty member of Shanxi Eye Hospital specializing in the treatment of cataract and retinal disease and a tutor for postgraduate students of Shanxi Medical University, worked in the COOL Lab as an international visiting scholar under the supervision of Dr. David Huang and Yali Jia from October 2012 through November 2013. Dr. Wang earned an MD from Shanxi Medical University and a Ph.D. from Shanghai Jiao Tong University. Dr. Wang was awarded two research project grants focused on multimodal optical coherence tomography imaging and deep learning in cataract and retinal disease, from the National Natural Science Foundation of China. He has published around 30 peer-reviewed journal papers and four book chapters and co-edited one book.",institutionString:null,institution:null},{id:"7227",title:"Dr.",name:"Hiroaki",middleName:null,surname:"Matsui",slug:"hiroaki-matsui",fullName:"Hiroaki Matsui",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Tokyo",country:{name:"Japan"}}},{id:"312999",title:"Dr.",name:"Bernard O.",middleName:null,surname:"Asimeng",slug:"bernard-o.-asimeng",fullName:"Bernard O. 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This will ensure that we discover ways to live in our world that allows us and other beings to flourish. We can no longer rely on medicalized approaches to health that wait for people to become ill before attempting to treat them. We need to live in harmony with nature and rediscover the beauty and balance in our everyday lives and surroundings, which contribute to our well-being and that of all other creatures on the planet. This topic will provide insights and knowledge into how to achieve this change in health care that is based on ecologically sustainable practices.
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