More than half of the publishers listed alongside IntechOpen (18 out of 30) are Social Science and Humanities publishers. IntechOpen is an exception to this as a leader in not only Open Access content but Open Access content across all scientific disciplines, including Physical Sciences, Engineering and Technology, Health Sciences, Life Science, and Social Sciences and Humanities.
\\n\\n
Our breakdown of titles published demonstrates this with 47% PET, 31% HS, 18% LS, and 4% SSH books published.
\\n\\n
“Even though ItechOpen has shown the potential of sci-tech books using an OA approach,” other publishers “have shown little interest in OA books.”
\\n\\n
Additionally, each book published by IntechOpen contains original content and research findings.
\\n\\n
We are honored to be among such prestigious publishers and we hope to continue to spearhead that growth in our quest to promote Open Access as a true pioneer in OA book publishing.
Simba Information has released its Open Access Book Publishing 2020 - 2024 report and has again identified IntechOpen as the world’s largest Open Access book publisher by title count.
\n\n
Simba Information is a leading provider for market intelligence and forecasts in the media and publishing industry. The report, published every year, provides an overview and financial outlook for the global professional e-book publishing market.
\n\n
IntechOpen, De Gruyter, and Frontiers are the largest OA book publishers by title count, with IntechOpen coming in at first place with 5,101 OA books published, a good 1,782 titles ahead of the nearest competitor.
\n\n
Since the first Open Access Book Publishing report published in 2016, IntechOpen has held the top stop each year.
\n\n\n\n
More than half of the publishers listed alongside IntechOpen (18 out of 30) are Social Science and Humanities publishers. IntechOpen is an exception to this as a leader in not only Open Access content but Open Access content across all scientific disciplines, including Physical Sciences, Engineering and Technology, Health Sciences, Life Science, and Social Sciences and Humanities.
\n\n
Our breakdown of titles published demonstrates this with 47% PET, 31% HS, 18% LS, and 4% SSH books published.
\n\n
“Even though ItechOpen has shown the potential of sci-tech books using an OA approach,” other publishers “have shown little interest in OA books.”
\n\n
Additionally, each book published by IntechOpen contains original content and research findings.
\n\n
We are honored to be among such prestigious publishers and we hope to continue to spearhead that growth in our quest to promote Open Access as a true pioneer in OA book publishing.
\n\n
\n\n
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1. Introduction
Fuzzy control is a practical alternative for a variety of challenging of challenging control applications because it provides a convenient method for constructing nonlinear controllers via the use of heuristic information. The heuristic information may come from an operator who has acted as a human controller for a process. In the fuzzy control design methodology, a set of rules are written down by the operator on how to control the process, then make these into a fuzzy controller that emulates the decision-making process of the human. In some cases, the heuristic information may come from other novel intelligent applications. In other cases, the heuristic information may come from a control engineer who has performed extensive mathematical modeling, analysis, and development of control algorithms for a particular process. Regardless of where the heuristic control knowledge comes from, fuzzy control provides a user-friendly formalism for representing and implementing the ideas.
Over the past few decades, fuzzy logic theory is widely used: process control, management and decision making, operations research, economies. Dealing with simple ‘yes’ and ‘no’ answers is no longer satisfactory enough; a degree of membership (Zadeh, 1965) became a new way of solving problems. Fuzzy logic derives from the truth that the human common sense reasoning mode is approximate in nature.
In this chapter we provide a control engineering perspective on novel fuzzy controller. We take a pragmatic engineering approach to the design, analysis, performance evaluation, and implement of fuzzy control system. The chapter is basically broken into five parts. In section I, we provide an overview of conventional control system design. In section II the basic theories of variable universe fuzzy control are been introduced. In section III,we cover the novel fuzzy controller based on Yinger algorithm. In section IV, we use some examples to show how to design, simulate, and implement these controllers. Finally, in section V,we explain how to write a computer program to simulate the novel fuzzy control system, using either a high-level language or Matlab.
2. Conventional control system design
2.1. Introduction
A control system is a device, or set of devices to manage, command, direct or regulate the behavior of other devices or system.There are two common classes of control systems, with many variations and combinations: logic or sequential controls, and feedback or linear controls. There is also fuzzy logic, which attempts to combine some of the design simplicity of logic with the utility of linear control. Some devices or systems are inherently not controllable. A basic control system is shown in figure 1. The plant is object to be controlled. Its inputs areu(t), its outputs arey(t), and reference input isr(t).
Figure 1.
Control system
2.2. Mathematical modeling
The mathematical model is a description of a system using mathematical concepts and language. The process of developing a mathematical model is termed mathematical modeling. Mathematical models are used not only in the natural sciences (such as physics, biology, earth science, meteorology) and engineering disciplines (such as computer science, artificial intelligence), but also in the social sciences (such as economics, psychology, sociology and political science),physicists, engineers, statisticians, operations research analysts and economists use mathematical models most extensively. A model may help to explain a system and to study the effects of different components, and to make predictions about behaviour.
Mathematical models can take many forms, including but not limited to dynamical systems, statistical models, differential equations, or game theoretic models. These and other types of models can overlap, with a given model involving a variety of abstract structures. In general, mathematical models may include logical models, as far as logic is taken as a part of mathematics. In many cases, the quality of a scientific field depends on how well the mathematical models developed on the theoretical side agree with results of repeatable experiments. Lack of agreement between theoretical mathematical models and experimental measurements often leads to important advances as better theories are developed.
When a control engineer is given a control problem, often one of the first tasks is the development of a mathematical model of the process to be controlled, in order to gain a clear understanding of the problem. Basically,there are only a few ways to actually generate the model.We can use first principles of physicsto write down a model.Another way is to perform"system identification" via the use of real plant data to produce a model of the system.Sometimes a combined approach is used where we use physics to write down a general different equation that we believe represent the plant behavior,and then we perform experiments on the plant to determine certain model parameters or functions.
Often,more than one mathematical model is produced.A"truth model" is one that is developed to be as accurate as possible so that it can be used in simulation-based evaluations of control systems.It must be understood,however,that there is never a perfect mathematical model for the plant.The mathematical model is an abstraction and hence cannot perfectly represent all possible dynamics of any physical process.This is not to say that we cannot produce models that are "accurate enough" to closely represent the behavior of a physical system.Usually,control engineer to be able to design a controller that will work.Then,they often also need a very accurate model to test the controller in simulationbefore it is tested in an experimental setting.Hence,lower-order "design model" are also often developed that may satisfy certain assumption yet still capture the essential plant behavior.Indeed,it is quite an artto produce good low-order model that satisfy these constraints.We emphasize that the reason we often need simpler models is that the synthesis techniques for controller often require that the model of the plant satisfy certain assumptionsor there methods generally cannot be used.
Linear models such as the one in Equation(1) have been used extensively in the past and the control theory for linear system is quite mature.
x˙=Ax+Buy=Cx+DuE1
In this case u is the m-dimensional input; x is the n-dimensional state; y is the p-dimensional output; and A,B,C and D are matrices of appropriate dimension. Such models are appropriate for use with frequency domain design techniques, theroot-locus method,state-space methods,and so on.Sometimes it is assumed that the parameters of the linear model are constant but unknown,or can be perturbed form their nominal values.
Much of the current focus in control is on the development of controllers using nonlinear models of the plant of the form
x˙=f(x,u)y=g(x,u)E2
Where the variables are defined as for the linear model and f and g are nonlinear functions of their arguments.One form of the nonlinear model that has received significant attention is
x˙=f(x)+g(x)uE3
Since it is possible to exploit the structure of this model to construct nonlinear controllers.Of particular with both of the above nonlinear models is the case where f and g are not completely known and subsequent research focuses on robust control of nonlinear system.
Discrete time versions of the above models are also used,and stochastic effect are often taken into account via the addition of a input or other stochastic effects.Under certain assumptions you can linearize the nonlinear model in Equation(2) to obtain a linear one.In this case we sometimes think of the nonlinear model as the truth model,and the linear model that are generated form it as control design model.
There are certain properties of the plant that the control engineer often seeks to identify early in the design process.For instance,the stability of the plant may be analyzed.The effects of certain nonlinearities are also studied. The engineer may want to determine if the plant is controllable to see, for example, if the control input will be able to properly affect the plant; and observable to see, for example, if the chosen sensors will allow the controller observe the critical plant behavior so that it can be compensated Overall,this analysis of the plant\'s behavior gives the control engineer a fundamental understanding of the plant dynamics.
2.3. Performance objectives and design constrains
Controller design entails constructing a controller to meet the specifications. Often the first issue to address is whether to use open or closed-loop control. Often, need to pay for a sensor for the feedback information and there need to justification for this cost. Moreover, feedback can destabilize the system. Do not develop a feedback controller just because you are used to developing feedback controllers; you may want to consider an open-loop controllers since it may provide adequate performance. Assuming you use feedback control, the closed-loop specifications can involve the following factors: Disturbance rejection properties; Insensitivity to plant parameter variations; Stability; Rise-time.
2.4. Controller design
Conventional control has provided numerous methods for controllers for dynamic system. Some of there are listed below:
Proportional-integral-derivative(PID) control:Over 90% of the controllers in operation today are PID controllers. This approach is often viewed as simple, reliable,and easy to understand. Often, like fuzzy controller, heuristics are used to tune PID controllers.
State-space methods: State feedback,observers,and so on.
Optimal control: Linear quadratic regulator,use of Pontryagin\'s minimum principle or dynamic programming,an so on.
Nonlinear methods: Feedback linearization, Lyapunov redesign, sliding mode control, backstepping, and so on.
Adaptive control; model reference adaptive control,self-tuning regulators, nonlinear adaptive control,and so on.
Basically,there conventional approaches to control system design offer a variety of ways to utilize information from mathematical model on how to do good control. Sometimes they do not take into account certain heuristic information early in the design process, but use heuristics when the controller is implemented to tune it(tuning is invariably needed since the model used for the controller development is not perfectly accurate).Unfortunately, when using some approaches to conventional control, some engineers become somewhat removed from the control problem, and sometimes this leads to the development of unrealistic control laws. Sometimes in conventional control, useful heuristics are ignored because they do not fit into the proper mathematical framework, and this can cause problem.
2.5. Performance evaluation
The next step in the design process is to perform analysis and performance evaluation. Basically, we need performance evaluation to test that we design does in fact meet the closed-loop specifications. This can be particularly important in safety-critical applications such as the control of a washing machine or an electric shaver, it may not be as important in the sense that failures will not imply the loss of life, so some of the rigorous evaluation methods can sometimes be ignored. Basically, there are three general ways to verify that a control system is operating properly:(1) mathematical analysis based on the use of formal models, (2) simulation-based analysis that most often uses formal models, and (3) experimental investigations on the real system.
3. Variable fuzzy control system design
The fuzzy controller block diagram is given in figure 2. The plant outputs are denoted byy(t), its input is denoted byu(t), and the reference input to the fuzzy controller is denoted byr(t).
Figure 2.
Fuzzy controller architecture
3.1. Fuzzy controller
Basically, the difficult task of modeling and simulating complex real-world systems for controller systems development, especially when implementation issues are considered, is well documented. Even if a relatively accurate model of a dynamic system can be developed, it is often too complex to use require restrictive assumptions for the plant. It is for this reason that in practice conventional controllers are often developed via simple models of the plant behavior that satisfy the necessary assumptions, and via the ad hoc tuning of relatively simple linear or nonlinear controllers. Regardless, it is well understood.
Fuzzy control provides a formal methodology for representing, manipulating, and implementing a human’s heuristic knowledge about how to control a system.
The fuzzy controller block diagram is given in Figure 2, where we show a fuzzy controller embedded in a closed-loop control system. The plant outputs are denoted by y(t), its inputs are denoted by u(t), and the reference input to the fuzzy controller is denoted by r(t).
The fuzzy controller has four main components: (1) The” rule-base” holds the knowledge, in the form of a set of rules are relevant at the current time and then decides what the input to the plant should be, (3) The fuzzification interface simply modifies the inputs so that they can be interpreted and compared to the rules in the rule-base. And (4) the defuzzification interface converts the conclusions reached by the inference mechanism into the inputs to the plant.
To design the fuzzy controller, the control engineer must gather information on how the artificial decision maker should act in the closed-loop system. Sometimes this information can come from a human decision maker who performs the control task, while at other times the control engineer can come to understand the plant dynamics and write down a set of rules about how to control the system without outside help. These “rules” basically say, “If should be some value.” A whole set of such “If-Then” rules is loaded into the rule-base, and specifications are met.
3.2. Structure of variable adaptive fuzzy controller
LetXi=[−E,E](i=1,2,⋯,n) be the universe of input variablexi(i=1,2,⋯,n), and Y=[−U,U] be the universe of output variabley. μi={Aij}(1≤j≤m) stands for a fuzzy partition on Xi,and Β={Bj}(1≤j≤m) defines a fuzzy partition onY. A group of fuzzy inference rules is formed as follow:Ifx1isA1jandx2isA2jand…andxnisAnjthen y isBj, j=1,2,⋯,m
The fuzzy logic system can be represented as an n-dimension piecewise interpolation function F(x,x2,⋯,xn):
F(x,x2,⋯,xn)=y(x,x2,⋯,xn)=∑j=1m∏i=1nAij(xi)yjE4
Generally speaking, a function α:X→[0,1],x→α(x)can be called a contraction-expansion factor onXi=[−E,E]. The so-called variable universe meansXi andYcan change with changing variablexi and y expressed by:
Xi(xi)=[−α(xi)Ei,α(xi)Ei]E5
Y(y)=[−β(y)U,β(y)U]E6
Figure 3.
Universe compress and expand
4. Novel fuzzy controller based on Yinger algorithm
Novelfuzzy controller is composed of three parts. Firstly, new kind of contraction-expansion factor is established, then local space is optimized, finally novel controller dynamically adjust output by rules.
4.1. Optimal local spaces
Many real-world environments in which learning systems have to operate are time-varying. Several aspects of the learning problem can vary, including the mapping to be learned, and the sampling distribution that governs the input-space location of exemplars that make up the input information. In this section, K-Vector Nearest Neighbors (K-VNN) is proposed to this problem.
Define 1. Lets Ωk is input sets which can be defined to local space as:
Ωk≡{X1,⋯,XK}={Xi|D(Xi,Xm)<h}E7
Where his radius of local space (Ωk), and data-window is changed by adjusting it. D(A,B)isthe distance function which is defined by (8), X1,⋯,XK are messages to input.
Define 2.Lets A=[A1,⋯,An] and B=[B1,⋯,Bn],in the Euclidean space, gets distance and intersection angle:
{d(A,B)=‖A−B‖2θ(A,B)=arccosATB‖A‖2•‖B‖2E8
According to (7), we can get the distance and intersection angle of XiandXd, from input-output specimen choice similar message toΩk.
If intersection angle of Xi and Xd.greater than 90∘, thinking Xi stray from Xd,and define as follows:
From (9), we can see, ifXi ismore similar toXd, e[−d(Xi,Xd)]and sin[φ(Xi,Xd)] are more similar to 1, use this method and get the new input set
Ωk={(X1,Y1),⋯,(XK,YK)|D(X1,Xd)>⋯>D(Xk,Xd)}E10
From this section, some noise can be deleted by this section.
4.2. Contraction-expansion factor
Now the popular contraction-expansion factor is α(x)=1−ce(−kx2) (c∈(01)k≥0), but the algorithm module can not be realized easily by C++ which support some methods by using VC++ accomplish control system. So building up a kind of contraction-expansion factor to nonlinear system is very important.
1. Establish differential equation
Firstly, α(e(t))is strictly monotonously increasing on [0 1] and monotonously decreasing on [-1 0].
Thirdly,Δα(e(t))=kΔe(t), and to the same Δe(t), e(t)is larger andΔα(e(t))is larger too. From those conditions the differential equation can be build as follow:
Δα(e(t))=ke(t)Δe(t)(E−e2(t))E11
get hold of:
α(x)=−14kx4+E2kx2+cE12
and initialized condition:
when e(t)=0thenα(e(t))=D(Xi,Xd),and |e(t)|=Eα(e(t))=1
In order to make out the advantages of the new function, Let r(t)=sint the result of controller (see Fig.11) is formed as follows
Figure 11.
The contrast of control effect
Let r(t)={1.50≤t≤3and6≤t≤90.5etc
the result of control (see Fig.12 and Fig.13) is formed as follow
From Fig.12, we learn that there are some errors between aim curve (blue) and real curve (black) because of α(e(t))=1.System cannot immediately regulate control strategy to make e(t)=0. From Fig.13, we can clearly learn that the real curve (black)almost coincide with aim curve (blue). So we say that the variable fuzzy controller is one of the efficient tools for control system. From Fig.11, we can see the difference between the new function and exponential function (conventional function), and the algorithm module with new contraction-expansion factor is applied successfully in Matlab, whose results show that algorithm module is reasonable, adaptive and feasible. In the other hand, the new function can be realized easily by C++ to optimize the controller of complicated nonlinear control system.
Figure 12.
The simulation curves (α(e(t))=1)
Figure 13.
The simulation curves (T=10)
6. Practical application
Refrigerator is one kind of popular home appliance, and it became more and more important to economize the energy. The controller of conventional refrigerator keep anticipative temperature through PTC-relays and compress, but a lot of energy is waste. In this paper the new controller based on variable universe adaptive fuzzy control theory can resolve this problem. The variable universe fuzzy control theory has become more and more important in process control. The idea of variable universe fuzzy control is first proposed in refs,and several types of variable universe adaptive fuzzy controller are discussed in ref.
The compressor, condenser, evaporator,capillary and other electro-equipments compose the refrigeration system which is a close circulatory system. R-600a as refrigeration material from the low-pressure liquid to gaseity in evaporator to make the icebox inside temperature lowed through absorbing the heat. In other words, the control system of refrigeration makes R-600achanged by electric power. The simplified model of the refrigerator (see Fig.14) show as follow:
Figure 14.
Simplified model of the refrigerator
The popular refrigerator through driving compressor makes the temperature constant, but there are some disadvantages in the control strategy. If there is minuteness temperature warp in system, control system frequent start-up equipments to modulate inside temperature, and a lot of energy will be wasted. In order to solve this problem, we design the new control strategy based on the idea of variable universe fuzzy control.
Figure 15.
Contrast of controller effect
A refrigerator plant is a complex nonlinear systemand may be prone to instability and oscillatory behaviors. The Fig.15 is the contrast of controller effect by Ying learning (red line), exponent function (blue line).In this section, a fuzzy controller is designed and simulated exclusively to control a refrigerator plant with a new-type function of contraction-expansion factor to optimize the controller of temperature is steady.
Using control method to explain medical phenomenon is currently a hot subject of research. The traditional Chinese drug fumigation steaming treat protrusion of protrusion of protrusion of lumbar intervertebral disc with steam generated by boiling medicinal herbs, and this process is a typical non-linear, multivariable, and strong coupling. Experienced nurse and doctor cure patient by their experience. So establish a model of this process can discover more factor of the disease, better treat to protrusion of protrusion of protrusion of lumbar intervertebral disc and reduce of energy consumption.
The traditional Chinese drug fumigation fume or steaming treat diseases with fume in moxibustion or with steam generated by boiling medicinal herbs, and its process is a typical non-linear, multivariable, strong coupling. In addition, its characters are difficult to quantitative analysis. So the period of treatment is only determined by experience of doctors. Therefore, there is theoretical and practical significance in studying of traditional Chinese drug fumigation medical data mining.
The illustration of the traditional Chinese drug fumigation machine is shown in Fig.16. Here, the type of machine is MJD-2003 and it has been used 6 years.
Figure 16.
Drug Fumigation Machine
Doctor treats protrusion of Protrusion of protrusion of lumbar intervertebral disc with steam generated by boiling medicinal herbs at this machine.
Fig.17 is the temperature of steam to body by VUF and YL-VUF. YL-VUF is the blue real line, and VUF is the green dash line. In this picture the aim is 40 Celsius Degrees. The temperature decrease when patient’s posture is changed. After 10.725 minute, YL-VUF makes the temperature to 40 Celsius Degrees. On the other hand, VUF almost cost 22.568 minute. DFNN and YL-VUF have the similar frame, but YL-VUF using new local space to forecast. So YL-VUF can avoid over heat.
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Introduction",level:"1"},{id:"sec_2",title:"2. Conventional control system design",level:"1"},{id:"sec_2_2",title:"2.1. Introduction",level:"2"},{id:"sec_3_2",title:"2.2. Mathematical modeling",level:"2"},{id:"sec_4_2",title:"2.3. Performance objectives and design constrains",level:"2"},{id:"sec_5_2",title:"2.4. Controller design",level:"2"},{id:"sec_6_2",title:"2.5. Performance evaluation",level:"2"},{id:"sec_8",title:"3. Variable fuzzy control system design",level:"1"},{id:"sec_8_2",title:"3.1. Fuzzy controller",level:"2"},{id:"sec_9_2",title:"3.2. Structure of variable adaptive fuzzy controller",level:"2"},{id:"sec_11",title:"4. Novel fuzzy controller based on Yinger algorithm",level:"1"},{id:"sec_11_2",title:"4.1. Optimal local spaces",level:"2"},{id:"sec_12_2",title:"4.2. Contraction-expansion factor",level:"2"},{id:"sec_14",title:"5. Examples",level:"1"},{id:"sec_15",title:"6. 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1. Introduction
The respiratory system is anatomically divided into the following two parts: upper respiratory tract (organs outside the chest: nose, pharynx, and larynx) and lower respiratory tract (organs inside the chest: trachea, bronchi, bronchioles, alveolar ducts, and alveoli). This system that performs three basic functions, i.e., air transmission, air filtration, and gas exchange (respiration), is functionally divided into two zones. These are the conductive zones (from the nose to the bronchioles) that act as a pathway for the delivery of inhaled gases, and the respiratory zone (from the alveolar canal to the alveoli) where gas exchange occurs. The branching pattern of the conducting passages is known as the tracheobronchial tree as it resembles the branching of a tree [1].
The lungs, the main organ of the respiratory system, are divided into two sections depending on the functions of their structural parts. These are the tubes that conduct air (bronchi and bronchioles) and respiratory tissue (alveolar ducts, alveolar sacs, and alveoli). Ventilated by a secondary (lobar) bronchus, each lobe of the lung is divided into smaller pyramidal-shaped segments known as the bronchopulmonary segments and is ventilated by a tertiary (segmental) bronchus [2].
The bronchi of the lower respiratory tract are vital in terms of respiratory aspects because they are responsible for the transmission and filtration of air as well as for key immunological functions.
1.1 Bronchial structure
The bronchial wall is microscopically composed of the following five sections: mucosa, muscle, submucosa, cartilage, and peribronchial connective tissue (adventitia) (Figure 1) [3].
Figure 1.
Light microscopic view of the bronchial wall, rat lung (H-E). Black star: bronchial lumen, black arrow: respiratory epithelium layer, white arrow: lamina propria layer, red arrow: smooth muscle layer, yellow arrow: submucosa layer, white star: distinctive lung tissue (LT) showing the many empty spaces of pulmonary alveoli.
The epithelial and lamina propria layers constitute the bronchial mucosa layer, which has the characteristics of the respiratory mucosa. The initial part of the bronchi exhibits a similar structure to that of the trachea, which is a pathway responsible for the transmission of air taken from the external environment into the lungs. The structure of the bronchial wall changes histologically at the point where it enters the lungs and transforms into intrapulmonary bronchi. In the beginning, the bronchial mucosa comprises a layer of respiratory epithelium with the same cellular composition as the trachea. The height of the cells of this ciliated layer, also known as the pseudostratified columnar epithelium, decreases in proportion to the diameter of the bronchus. The prominent cell types in the epithelium are ciliated cells, goblet cells, basal cells, brush cells, and neuroendocrine cells. The epithelial layer is separated from other mucosal layers by a basement membrane [4].
The basement membrane is prominent in the primary bronchi; however, it rapidly decreases in thickness and disappears as a separate structure in the secondary bronchi. The lamina propria layer is similar to the trachea, but it decreases in proportion to the diameter of the bronchi. The lamina propria layer, which appears as a typical loose connective tissue with abundant elastic and collagen threads, is rich in cellular structures. In addition to the cell types such as plasma cells, mast cells, eosinophils, and fibroblasts, it comprises a large number of lymphocyte cells. The lymphocytes in this layer gather in the form of infiltrates at some places and lymph follicles at some [3].
The muscularis layer, which comprises multiple rows of circular smooth muscle cells, is a continuous layer of smooth muscles in the large bronchi. However, in the small bronchi, it is weakly and loosely organized because it may appear discontinuous due to its spiral route. This layer is responsible for determining the appropriate airway diameter for airflow regulation. In the large bronchi, the loose connective tissue submucosa layer is evident, whereas in the small bronchi, it is only observed as a narrow patch. In addition to the venous plexus and lymph follicles, bronchial glands known as GI. bronchioles are quite common in this layer. These glands, similar to salivary gland tissue, comprise a mixture of serous and mucinous cells and decrease in quantity as the diameter of the bronchi decreases (Figure 2) [3, 5].
Figure 2.
A higher power light microscopic view of the bronchial wall, rat lung (H-E). Black arrow: respiratory epithelium layer, white arrow: lamina propria layer, red arrow: smooth muscle layer.
The cartilage layer is observed as a whole in the trachea, whereas it is irregularly present at the beginning of the bronchi in the form of hyaline cartilage. As the diameter of the bronchus decreases, the fragmented cartilage layer becomes smaller and appears as elastic cartilage. On the other hand, the peribronchial connective tissue (adventitia) layer is dense that limits the bronchi from the alveoli and is rich in nerve and elastic fibers in addition to large blood and lymph vessels [3].
2. Bronchi immunology
The lower respiratory tract is constantly exposed to a wide variety of airborne foreign bodies because it is in direct communication with the external environment for gas exchange [6]. Both the trachea and bronchi function as filters against this exposure due to some of their structural features. The bronchial epithelium has a similar histological structure to the trachea and can capture foreign bodies through the smear of the mucus film secreted by the goblet cells to the kinocilium at the apical ends of the prismatic cells present in its structure. These bodies are captured and removed from the lungs by the movement of the kinocilium toward the larynx [7]. Mechanical filtering of inhaled air is thus ensured due to this primary defense mechanism.
The lower respiratory tract is constantly exposed to allergens, antigens, bacteria, and viruses during gas exchange. This is a very sensitive area for various types of pathogen invasions, such as influenza virus, measles virus, and Mycobacterium tuberculosis [8]. Producing rapid and specific adaptive immune responses against these factors are important for survival [6]. At the initial stage of an adaptive immune response, naive T cells migrate through the endothelial venules of blood vessels to secondary lymphoid tissues, where they are stimulated by antigen-bearing cells. This is critical for the development of appropriate adaptive immunity. This migration therefore leads to the generation of antigen-specific effector and memory T and B cells released from the secondary lymphoid tissue into the bloodstream. In the effector stage of the adaptive immune response, some memory T and B cells migrate from blood vessels to non-lymphoid tissues containing cognate antigens or pathogens [9, 10]. Bronchial lymphoid tissue and lymphatic nodes, two types of secondary lymphoid tissue found in the bronchial mucosa of the lower respiratory tract, are important in this regard [11, 12]. These secondary lymphoid tissues play a key role in the development of bronchopulmonary immune responses. Therefore, the bronchopulmonary adaptive immune system plays an important role in maintaining health as well as in the development of lower respiratory tract diseases [6].
The tracheobronchial tree, which is considered as an immunological organ, [13] is important for the defense mechanism of microorganisms reaching the lungs through inhaled air as well as for hypersensitive reactions that occur through respiration. The lymphoid tissue of the tracheobronchial system contains specialized diffuse, clustered, and solitary lymphatic nodules known as bronchus-associated lymphoid tissue [14, 15]. This secondary lymphoid tissue is a representative of the mucosal immune system in the bronchial wall, which is common in different parts of the body. It forms the immunoglobulins as a result of the immune defense reaction, thus forming a special protective mechanism of the lower respiratory system.
3. Mucosa-associated lymphoid tissue (MALT)
The immune system can recognize a wide range of unknown antigens and elicit an appropriate respond due to the lymphocytes that have a wide variety of antigen receptors [16]. This system has evolved into a system of secondary lymphoid organs such as the spleen, lymph nodes, Peyer’s patches, and other MALT, in line with the defense targets [17]. Highly organized secondary lymphoid organs contain architectural domains that facilitate sequential cellular interactions between antigen-presenting cells and lymphocytes and efficiently promote the activation, selection, and differentiation of B and T cells [16]. Therefore, the immunological response becomes more effective.
MALT can function independently of the systemic immune system and therefore encompasses the mucosal immune system, which is a crucial part of immunopathology [18]. It plays an important role in immunological defense by eliciting immune responses against specific antigens encountered along the surfaces of all mucosal tissues [19]. Although MALT is anatomically divided into regions, these regions are functionally interconnected under the name of the common mucosal immune system. In this way, events such as antigen presentation and B-cell activation in a mucosal region can trigger the secretion of immunoglobulin A (IgA) in the mucosal regions of different organs [18, 20]. Due to MALT, which mainly functions to produce and secrete IgA along the mucosal surfaces in antigen-specific, T helper 2-dependent reactions, T helper 1 and cytotoxic T-cell-mediated reactions can occur. This may then result in immunotolerance [20, 21].
The best-known representatives of MALT, which contains approximately half of the lymphocytes of the immune system, [22] are gut-associated lymphoid tissue (GALT), nasal-associated lymphoid tissue (NALT), and BALT. However, structures such as conjunctival-associated lymphoid tissue (CALT), larynx-associated lymphoid tissue, and duct-associated lymphoid tissue (DALT) are other MALT representatives [20, 21].
MALT is divided into the two following functional parts: inducer sites and effector sites. Inducer sites include secondary lymphoid tissues, where the clonal expansion of B cells and IgA class transition occur in response to antigen-specific T-cell activation [19]. GALT, BALT, NALT, and CALT in mice, dogs [23], and baboons [24] and DALT in cynomolgus macaques [25] constitute these inducing sites. These sites are known as secondary immune tissues where antigen sampling occurs, and immune responses are initiated. Although there are many differences between inducing sites in various organs, they all contain the same functional segments as follows: lymphoid follicles, interfollicular zones, subepithelial dome zones, and follicle-associated epithelium or lymphoepithelium containing microfold (M) cells [19].
Effector sites distributed as diffuse lymphoid tissue throughout the lamina propria layer on all mucosal surfaces [26] are known as the transport sites of IgA along the mucosal epithelium. After activation and IgA class transition, T- and B cells migrate from inducing sites to these sites [19]. CD4+ and CD8+ T cells, IgA-, IgG- and IgM-plasma cells, B cells, antigen-presenting dendritic cells, and macrophages [19] constitute the cellular content of these effector regions where secreted IgA (S-IgA) is secreted along the mucosal epithelium [27]. Mast cells and eosinophils can occasionally be seen in the interfollicular area. Thus, all the cell types required to initiate an immune response are present here.
4. Bronchus-associated lymphoid tissue (BALT)
BALT, an important part of MALT, is classically used to refer to intrapulmonary lymphoid tissue in connection with the pulmonary vessels and adventitia of the bronchi [11, 28]. Macklin [29] named this lymphoid tissue in 1955 as ‘sumps’ or ‘pulmonary tonsils’ in which dust and organisms are retained. Subsequently, Bienenstock et al. [28, 30] identified these formations as subepithelial follicular lymphoid aggregates, primarily composed of lymphocytes, organized in the bronchial mucosa in contact with the surface epithelium, and coined the term BALT to describe them.
Although BALT, a secondary lymphoid tissue that plays an important role in the maintenance and regulation of lung mucosal immune homeostasis [8], was initially claimed to resemble Peyer’s patches in the small intestine [11]; it was later revealed that it was quite different from these formations [31]. Compared to GALT where in the founder Peyer’s patches are located, it is accepted that BALT is not regularly present during fetal life due to embryonic preprogramming; however, it occurs with antigenic stimulation during the postnatal period [32, 33]. In other words, it is claimed that there is a relatively special lymphoid tissue in the development of BALT. However, studies have shown that BALT exhibits great differences between species [34, 35].
BALT, which was first identified in the bronchial wall of rabbits by Bienenstock et al. [28], is frequently detected in these animals and has the highest number of regions [28, 34]. In terms of the presence and distribution of BALT, rats and guinea pigs [34] follow rabbits, whereas germ-free pigs [28, 34], cats, dogs, and Syrian hamsters [34, 36] do not have this lymphoid tissue. BALT is frequently present in poultry, particularly hens [37]. In mice and humans, the situation with BALT is a little more contradictory [19]. Some scientists suggest that BALT is present in germ-free mice when antigenic stimulation is absent [12], whereas others report that it is not [38, 39]. Besides the differing viewpoints on the presence of BALT in mice, it is assumed that it is only observed infrequently after the neonatal period.
Further, it is claimed that BALT is not present in structurally healthy humans [31] because the features similar to BALT in mice are also found in humans [8]. BALT, in particular, is detectable if it is induced in adults; however, it is only observed in 40% healthy children and adolescents. Factors inducing the presence and distribution of BALT in these adults include infection, pathogen exposure, chronic pulmonary inflammation or autoimmune disease, etc. [32, 33, 40]. Moreover, it is suggested that the formation, size, and amount of BALT depend on the type and duration of exposure [41]. Therefore, it is concluded that BALT varies in different species as well as indifferent physiological states of the same species [8].
4.1 Inducible BALT (İBALT)
Most of the secondary lymphoid organs found in mice and humans develop embryonically in the absence of microbial stimulation or environmental antigens [42]. Furthermore, the structure and function of several secondary lymphoid organs, particularly those on the mucosal surfaces, are dramatically altered upon exposure to foreign antigens and commensal organisms [43]. Peyer’s patches of MALT demonstrate a striking increase in size and complexity following the colonization of commensals [44, 45]. Similarly, in rodents, NALT is not completely developed until the postnatal period; however, microbial exposure accelerates this process [46]. On the other hand, the appendix tissue of rabbits has the characteristics of the primary and secondary lymphoid tissues in terms of being functionally dependent on microbial colonization [47]. However, some lymphoid tissues, known as tertiary lymphoid tissues, develop only after environmental exposure to microbes, pathogens, or inflammatory stimulations. Interestingly, although the lungs of mice and humans normally lack organized lymphoid tissue, tertiary lymphoid structures are frequently observed in lung tissue [38, 48].
BALT is recognized as an inducible tertiary or ectopic lymphoid tissue, unlike the related secondary lymphoid organs. BALT develops during the postnatal period and at anatomically non-lymphoid sites. In terms of disease states characterized by chronic inflammation, infection, or autoimmunity, BALT formation can be induced, and these areas are then known as iBALT [32, 38]. iBALT is a classic example of tertiary lymphoid tissue because it does not develop on a preprogrammed basis; its creation, size, and number in the lungs depend on the type and duration of antigenic exposure [31, 49]. iBALT regions are best characterized in the lungs of rodents and humans. They are observed in the lungs of mammals and birds as well as in possibly all air-breathing vertebrates [41]. The emerging arguments confirm the role of infectious agents, such as isolated lymphoid follicles in the gut, indicating that iBALT may develop in response to microbial exposure [32]. In contrast, BALT is said to have been discovered in germ-free rats [28] and mice [50] as well.
Unlike the classical BALT structure, iBALT does not always have an overlying lymphoepithelium, is not associated with a continuous airway, and can be located adjacent to small pulmonary arteries in the lung parenchyma [32]. However, as both BALT and iBALT have the same function, both tissue types are called BALT [48].
4.2 Microscopic structure of BALT
Microscopically, BALT is defined as a densely packed cluster of lymphocytes with follicular structures enveloped in a network of reticular stromal cells beneath a specialized airway epithelium devoid of cilium. These structures are claimed to be located along the main bronchial airways embedded in the airway wall with extensive lymphocytic infiltration of the epithelial layer forming a classical dome epithelium (Figures 3 and 4) [11].
Figure 3.
Light microscopic view of the BALT structure, rat lung (H-E). Red star: BALT formation.
Figure 4.
A higher power light microscopic view of the BALT structure, rat lung (H-E). Red star: BALT formation.
Further, it is stated that BALT is present in bronchial tree bifurcations to capture respiratory antigens. In species, BALT develops in response to various stimulations rather than being constitutively present in the lung, whereas iBALT does not always have such a defined structure or precise localization in the lung [51].
As a part of the integrated mucosal system including GALT, NALT, and other secondary lymphoid tissue representatives, BALT is known to contain cell types that are responsible for eliciting an appropriate immune response. BALT is mainly defined as an organized structure comprising T- and B-cell domains, dendritic cells (DCs), stromal cells, and high endothelial venules (HEVs) in the T-cell region [38, 52, 53, 54, 55]. Furthermore, it is stated that most of its cellular component consists of B cells expressing IgMlo IgDhi; however, depending on the nature of the microbe and/or antigen to which the cells respond, IgG-, IgA-, and even IgE-positive plasma cells may also be present [50, 56, 57, 58].
Moreover, in BALT, the most prominent structure is follicular-like lymphocyte accumulation, which is the common microscopic appearance of secondary lymphoid tissues, forming a classical germinal center (active site) [59, 60]. In this structure, surrounded by more mature, small lymphocytes, most of the germinal center comprises antigen-presenting macrophages [58, 61]. Lymphocytes leave the blood and migrate to BALT in the walls of HEVs, which are present at the periphery of the tissue. As there are no afferent lymphatics, these HEVs are thought to be the only entry site where lymphocytes migrate to BALT [59, 60]. In addition, the expression of chemokines in HEVs ensures accurate targeting of lymphocytes to lymphoid tissues [62].
However, in the direction of the bronchial epithelium, a dome-like protrusion similar to Peyer’s patches toward the bronchial lumen is sometimes clearly observed [31]. The B-cell follicle, which is the most noticeable characteristic in classic BALT tissues with dome epithelium, is positioned below the epithelium [11]. CD4+ T cells are abundant in B-cell follicles, especially in reactive follicles with germinal centers [63], and CD8+ T cells are uncommon. Moreover, BALT is covered by a lymphoepithelium, which contains M cells that are similar to the M cells present in the dome epithelium of Peyer’s patches in some species [31]. M cells are thought to transport antigens from the mucosal lumen to DCs that are in close contact with the dome epithelium [48]. Rabbits, the first and important representative of BALT, have fewer ciliated cells, few goblet cells, and many lymphocytes between epithelial and M cells. Although this basic structure appears to be valid for all species, there are some differences in details [31].
Another cell type that makes up the cellular component of BALT is follicular DCs (FDCs). These cells depend on the lymphotoxin signaling pathway to differentiate into conventional lymphoid tissues and BALT [38]. Located at the center of B-cell follicles, these cells present antigen to B cells [64] and provide costimulatory signals that increase B-cell activation and proliferation in germinal centers [65, 66]. FDCs in mice are characterized by their ability to bind to antibodies against CD21/CD35 [38], FDCM1, or FDCM2 [57] and to sequester their immune complexes [67]. In addition, FDCs are responsible for the organization of the follicle and expression of CXCL13, which is responsible for the recruitment of B cells and some T cells in the B-cell area [68]. DCs located at the highest concentration in the T-cell areas of BALT are reportedly capable of preserving the BALT architecture as well as their antigen-presenting ability [48].
BALT is induced to produce IgA+ cells that secrete polymeric IgA, mainly due to its role in immunity. When polymeric IgA is transported into the lumen, it induces the formation of S-IgA, which has considerable immunological importance [8]. Thus, when BALT is identified as part of the integrated mucosal immune system, the term should be restricted to structures tightly associated with an epithelium infiltrated by lymphocytes. In the integrated mucosal immune system, specific antigen uptake and antigen presentation by M cells occur and immune reactions are initiated, including IgA responses [31].
Immunohistological studies in humans show a preferential central localization of B cells mixed with some CD4+ lymphocytes and macrophages. CD4+ lymphocytes are also present in the area around the HEV, at the edge resembling a crown, and in the epithelium. In addition to the few proliferative cells positive for Ki67 observed in the follicles, many cells positive for the human leukocyte antigen-DR isotype, which is associated with various autoimmune conditions, disease susceptibility, and disease resistance, are evenly distributed in the follicle [69]. This basic structural distribution of lymphoid and non-lymphoid cells has also been noted in BALT in pathological conditions such as rheumatoid arthritis [70], hypersensitivity pneumonia [71], or diffuse panbronchiolitis [72]. Therefore, it is reasonable to conclude that BALT plays an important role in many respiratory system-related pathologies.
4.3 Role of BALT in various pathologies
BALT plays an important role in pulmonary immunity such as regulating microbial homeostasis [73], inducing immune tolerance [74], inhibiting inflammation [75], and supporting immune clearance [76]. Therefore, BALT frequently encounters many pathologies associated with infectious disease agents, allergens, environmental antigens, air-borne particles, autoimmune disease agents, and factors causing malignancy. As these pathological conditions have a broad spectrum, it is not possible to discuss all the roles of BALT; therefore, only a few have been addressed.
4.3.1 Role of BALT in resistance to infectious diseases
The respiratory tract is a typical entry site for viruses. This makes it difficult for the immune system to effectively eliminate viruses and virus-infected cells without causing much damage and inflammation, which jeopardizes the lung’s structural and functional integrity. The balance between eliciting an immune response to effectively eliminate viruses and virus-infected cells and to cause less damage and inflammation is maintained by a complex network of innate and adaptive immune mechanisms as well as immunomodulatory and anti-inflammatory mechanisms. Accordingly, BALT could be one of the mechanisms that facilitates viral clearance by eliciting immune responses and decreasing inflammatory responses [48]. BALT reportedly initiates pulmonary immune responses that are faster and more protective than those initiated at systemic sites. It has been proposed that once generated, BALT could play a key role in combating successive rounds of the same infection as well as assisting in establishing local immunity against unrelated viruses or pathogens [51]. For example, it has been suggested that Lta_/_ mice without lymph nodes and Peyer’s patches are more susceptible to the influenza virus and although they elicit immune responses, both B- and T-cell responses are delayed. Based on flow cytometric identification of germinal center B cells in the lung to question where immune responses might be initiated, it was concluded that both B- and T-cell responses are probably produced in the lungs [77]. BALT is suggested to be formed in the lungs of Lta_/_ mice and locally initiates immune responses against influenza because the germinal center is present only in secondary lymphoid tissues. Another study reported that, in addition to germinal centers, plasma cells specific to influenza nucleoprotein were detected in BALT after influenza infection [58]. However, B-cell responses to influenza are accelerated in mice with pre-existing BALT, and morbidity and mortality rates are markedly reduced in response to a variety of viruses, including influenza, severe acute respiratory syndrome coronavirus, and mouse pneumovirus [78].
Mycobacterium tuberculosis (Mtb) infection is one of the serious health threats worldwide and is typically confined to the lungs. Although local immune mechanisms are primarily responsible for keeping Mtb infection under control, once the infection has settled in the lungs, immune mechanisms alone do not appear to be capable of eliminating these bacteria [79]. In humans, Mtb is localized to the granulomas comprising a central nucleus surrounded by macrophages, multinucleated giant cells, and lymphocytes [80]. The lymphocyte clusters surrounding these granulomas are B cells that form structures similar to BALT. These BALT areas associated with granuloma have B-cell follicles, and T-cell areas are present at the outer edge of the follicles [81]. Similar BALT domains, for example, have been discovered in murine models of Mtb infection, where B-cell clusters surrounding the granuloma were observed. Well-defined B-cell domains with FDCs are formed as early as day 42 after pulmonary infection and are protected from infection until at least day 90 [82]. Considering the link between B follicular structures surrounding the granuloma and Mtb uptake, another study showed that B-cell follicles formed around Mtb lesions in mice developed large germinal centers, and the B cells responded to the antigen [83]. Therefore, it is indicated that BALT initiates local pulmonary immune responses against Mtb infection via B cells.
4.3.2 Role of BALT in pulmonary responses to allergens and environmental antigens
Endotoxin, known as lipopolysaccharide (LPS), is a component of the gram-negative bacteria [84, 85] that is commonly present in the environment [86, 87]. The development or exacerbation of asthma [86, 87], bronchitis, and chronic obstructive pulmonary disease [88, 89] is linked to considerable LPS exposure. LPS, a classical T-cell-independent B-cell antigen, and mitogen are thought to bind to TLR4 signaling pathway [84, 85], triggering B-cell activation, proliferation, and differentiation into antibody-secreting cells [90]. TLR4 signaling activates macrophages and DCs, epithelial cells, and even fibroblasts, causing them to produce inflammatory cytokines and chemokines [91, 92]. Experimentally, pulmonary exposure of rats to endotoxin has been found to cause increases in pre-existing BALT and pulmonary plasma cells, ultimately leading to the formation of germinal centers [93]. Sustained dosing of LPS prior to pulmonary inflammation in BALT-deficient mice appeared to result in BALT development in the major airways with an accumulation of B cells, T cells, and macrophages in the lungs, and even in BALT-deficient areas [94]. Thus, environmental exposures to LPS, often with additional antigenic or inflammatory components, cause BALT reactivity and pulmonary physiology alterations [95].
Considering the importance of pulmonary inflammation in asthma, a correlation between BALT development and asthma is likely. However, some believe that the presence of BALT is not always associated with asthma [96], but that the reactivity of BALT in patients with asthma is elevated [97]. Further, there is evidence that specific allergens, such as Aspergillus fumigatus, might cause pulmonary allergies that are similar to asthma. In allergic bronchopulmonary aspergillosis, large BALT regions characterized by diffuse and IgE-stained germinal centers have been found [98]. Thus, it is suggested that BALT can potentially contribute to allergic reactions by producing IgE locally in response to A. fumigatus.
Hypersensitivity pneumonia is defined as an inflammatory disease of the alveoli induced by hypersensitivity to inhaled organic antigens [99]. In contrast to asthma, which affects the airways, this condition affects the alveoli [48]. An occupational exposure often is the cause of hypersensitivity pneumonia; it can occur particularly when farmers are exposed to mold and fungi in barns [100]. Considering that hypersensitivity pneumonia results from chronic pulmonary exposure to the antigen, the emergence of well-developed BALT areas with vast germinal centers and FDC networks is not surprising for researchers [61].
4.3.3 Role of BALT in response to particles
The lungs are exposed to a wide range of particles, many of which are naturally inflammatory because they cannot be metabolized and persist in phagocytes or because their components bind to specific receptors that trigger an inflammatory response. Silicosis, for example, is a chronic diffuse parenchymal lung disease caused by prolonged exposure to inhaled crystalline silica particles. Pulmonary silica exposure reportedly results in nodules of mononuclear cell infiltration at the location of silica deposition, leading to pulmonary fibrosis [101]. It has been proposed that pulmonary exposure of rats to silica causes silica-loaded alveolar macrophages to migrate across the epithelium and accumulate in BALT [102]. This is analogous to the kinetic observation of virus-activated DCs in the airways migrating from the epithelium to BALT [40].
4.3.4 Role of BALT in autoimmune diseases
Rheumatoid arthritis (RA) and Sjögren’s syndrome (SS) are autoimmune disorders characterized by the formation of ectopic lymphoid follicles in target tissues. Ectopic lymphoid follicles in the joints are common in patients with RA [103]; whereas ectopic follicles in the salivary and lacrimal glands are common in those with SS [104]. These follicles are hypothesized to contain separate B- and T-cell domains, germinal centers, FDCs, and HEVs, and they contribute toautoimmunity by generating high-affinity autoreactive B cells and sparing autoreactive effector T cells. BALT areas are observed in lung biopsies from a subset of patients with RA and SS who develop lung disease. It has been suggested to range from very small isolated lymphoid follicles to large, highly organized clusters of B-cell follicles [61].
4.3.5 Role of BALT in pulmonary malignancy
BALT formation is frequently linked to lung inflammation and exposure to a variety of inflammatory stimuli. Therefore, it is not surprising that experimental exposure to an inflammatory agent via the pulmonary route results in BALT hyperplasia in rats. However, it is possible that an inflammatory agent, which has been linked to tumorigenesis, could also cause pulmonary adenocarcinoma [105]. Therefore, inflammatory responses in the lung can promote BALT and neoplasia at the same time. Indeed, considering the links between chronic inflammation and cancer development [106], it seems probable that BALT formation precedes tumorigenesis in such cases [48].
Local immune responses to pulmonary pathogens and antigens are clearly associated with BALT formation; thus, it is predicted that BALT development adjacent to pulmonary malignancies would also be beneficial for antitumor immune responses. A study demonstrated tertiary lymphoid tissue neogenesis induced by lymphotoxin: antitumor antibody fusion protein with the accumulations of CD4+ and CD8+ T cells, B cells, and PNAd-expressing HEVs [107]. Thus, it was hypothesized that the immune response necessary for tumor eradication was produced locally in tertiary lymphoid tissues [108]. Therefore, it is concluded that local BALT induction surrounding pulmonary metastases may be beneficial in inducing antitumor immunity and tumor regression [48].
In addition, it is suggested that the development of a lymphoid environment surrounding tumors may trigger antitumor immunity or immunological tolerance due to some unknown factors. Further, some studies indicate that lymphoid-like stromal elements surrounding tumors can impair antitumor immunity and lead to tolerance [109]. Despite the discrepancies and gaps in the literature, the ability of BALT to be spontaneously developed as a clear response to the development of pulmonary tumors or metastasis of other tumors to the lung as well as to boost immunity against lung tumors is an intriguing and research-worthy topic.
5. Conclusions
BALT covers a large area in the lungs, from small irregular lymphocytes and DC clusters to B-cell follicles, germinal centers, FDCs, HEV lymphatics, well-developed dome epithelium, and highly organized lymphoid tissues. It has the potential to help researchers better understand the mechanisms underlying chronic lung diseases, particularly in mammals. The potential contributions of BALT at this point are the collection of antigens from the pulmonary airways, priming B- and T-cell responses, and aiding in the clearance of pulmonary diseases. BALT becomes a functional tissue due to the induction of T cells and the production of deep lymphoid tissue, which functions in priming immune responses in the lung, including IgA-secreting plasma cells. The development of effective vaccines, particularly in the prevention of viral infections, will be aided by lymphoid tissue production.
Acknowledgments
This chapter was edited for English language by Crimson Interactive Inc. (Enago).
\n',keywords:"Bronchus-associated lymphoid tissue, local immune response, histology, inducible bronchus-associated lymphoid tissue, lung diseases",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/77999.pdf",chapterXML:"https://mts.intechopen.com/source/xml/77999.xml",downloadPdfUrl:"/chapter/pdf-download/77999",previewPdfUrl:"/chapter/pdf-preview/77999",totalDownloads:224,totalViews:0,totalCrossrefCites:0,dateSubmitted:"April 1st 2021",dateReviewed:"July 9th 2021",datePrePublished:"September 11th 2021",datePublished:null,dateFinished:"August 10th 2021",readingETA:"0",abstract:"The lower respiratory tract is in direct communication with the external environment for gas exchange to occur. Therefore, it is constantly exposed to allergens, antigens, bacteria, viruses, and a wide variety of airborne foreign bodies. Bronchus-associated lymphoid tissue (BALT), which develops in response to these exposures and is one of the most prominent representatives of mucosa-associated lymphoid tissue (MALT), is important for generating rapid and specific bronchopulmonary adaptive immune responses. Therefore, this chapter focuses on the lymphoid architecture of BALT, which was first discovered in the bronchial wall of rabbits, its inducible form called inducible BALT (iBALT), its immunological response mechanisms, and its roles in certain pathologies including infectious and autoimmune diseases as well as in allergic and malignant conditions. In conclusion, it is hypothesized that BALT plays an important role in maintaining health and in the development of lower respiratory tract diseases; thanks to the pulmonary immune system in which it functions as a functional lymphoid tissue.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/77999",risUrl:"/chapter/ris/77999",signatures:"Tuba Parlak Ak",book:{id:"10665",type:"book",title:"Updates on Veterinary Anatomy and Physiology",subtitle:null,fullTitle:"Updates on Veterinary Anatomy and Physiology",slug:null,publishedDate:null,bookSignature:"Dr. Catrin Rutland and Prof. Samir El-Gendy",coverURL:"https://cdn.intechopen.com/books/images_new/10665.jpg",licenceType:"CC BY 3.0",editedByType:null,isbn:"978-1-83969-530-8",printIsbn:"978-1-83969-529-2",pdfIsbn:"978-1-83969-531-5",isAvailableForWebshopOrdering:!0,editors:[{id:"202192",title:"Dr.",name:"Catrin",middleName:null,surname:"Rutland",slug:"catrin-rutland",fullName:"Catrin Rutland"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:null,sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_1_2",title:"1.1 Bronchial structure",level:"2"},{id:"sec_3",title:"2. Bronchi immunology",level:"1"},{id:"sec_4",title:"3. Mucosa-associated lymphoid tissue (MALT)",level:"1"},{id:"sec_5",title:"4. Bronchus-associated lymphoid tissue (BALT)",level:"1"},{id:"sec_5_2",title:"4.1 Inducible BALT (İBALT)",level:"2"},{id:"sec_6_2",title:"4.2 Microscopic structure of BALT",level:"2"},{id:"sec_7_2",title:"4.3 Role of BALT in various pathologies",level:"2"},{id:"sec_7_3",title:"4.3.1 Role of BALT in resistance to infectious diseases",level:"3"},{id:"sec_8_3",title:"4.3.2 Role of BALT in pulmonary responses to allergens and environmental antigens",level:"3"},{id:"sec_9_3",title:"4.3.3 Role of BALT in response to particles",level:"3"},{id:"sec_10_3",title:"4.3.4 Role of BALT in autoimmune diseases",level:"3"},{id:"sec_11_3",title:"4.3.5 Role of BALT in pulmonary malignancy",level:"3"},{id:"sec_14",title:"5. 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DOI: 10.1126/science.1185837'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Tuba Parlak Ak",address:"tubaparlakak@munzur.edu.tr",affiliation:'
Munzur University, Tunceli, Turkey
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To explore funding opportunities and learn more about how you can finance your IntechOpen publication, go to our Open Access Funding page. IntechOpen offers expert assistance to all of its Authors. We can support you in approaching funding bodies and institutions in relation to publishing fees by providing information about compliance with the Open Access policies of your funder or institution. We can also assist with communicating the benefits of Open Access in order to support and strengthen your funding request and provide personal guidance through your application process. You can contact us at funders@intechopen.com for further details or assistance.
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For Authors who are still unable to obtain funding from their institutions or research funding bodies for individual projects, IntechOpen does offer the possibility of applying for a Waiver to offset some or all processing feed. Details regarding our Waiver Policy can be found here.
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Added Value of Publishing with IntechOpen
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Choosing to publish with IntechOpen ensures the following benefits:
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Indexing and listing across major repositories, see details ...
\\n\\t
Long-term archiving
\\n\\t
Visibility on the world's strongest OA platform
\\n\\t
Live Performance Metrics to track readership and the impact of your chapter
\\n\\t
Dissemination and Promotion
\\n
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Benefits of Publishing with IntechOpen
\\n\\n
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Proven world leader in Open Access book publishing with over 10 years experience
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+5,700 OA books published
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Most competitive prices in the market
\\n\\t
Fully compliant with OA funding requirements
\\n\\t
Optimized processes that assure your research is made available to the scientific community without delay
\\n\\t
Personal support during every step of the publication process
\\n\\t
+184,650 citations in Web of Science databases
\\n\\t
Currently strongest OA platform with over 175 million downloads
As a gold Open Access publisher, an Open Access Publishing Fee is payable on acceptance following peer review of the manuscript. In return, we provide high quality publishing services and exclusive benefits for all contributors. IntechOpen is the trusted publishing partner of over 140,000 international scientists and researchers.
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The Open Access Publishing Fee (OAPF) is payable only after your book chapter, monograph or journal article is accepted for publication.
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OAPF Publishing Options
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1,400 GBP Chapter - Edited Volume
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850 GBP Chapter - Book Series Topic (Annual Volume)
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10,000 GBP Monograph - Long Form
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4,000 GBP Compacts Monograph - Short Form
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850 GBP Journal Article (Across Portfolio)
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During the launching phase journals do not charge an APC, rather they will be funded by IntechOpen.
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*These prices do not include Value-Added Tax (VAT). Residents of European Union countries need to add VAT based on the specific rate in their country of residence. Institutions and companies registered as VAT taxable entities in their own EU member state will not pay VAT as long as provision of the VAT registration number is made during the application process. This is made possible by the EU reverse charge method.
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Services included are:
\n\n
\n\t
An online manuscript tracking system to facilitate your work
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Personal contact and support throughout the publishing process from your dedicated Author Service Manager
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Assurance that your manuscript meets the highest publishing standards
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English language copyediting and proofreading, including the correction of grammatical, spelling, and other common errors
\n\t
XML Typesetting and pagination - web (PDF, HTML) and print files preparation
\n\t
Discoverability - electronic citation and linking via DOI
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Permanent and unrestricted online access to your work
\n
\n\n
What isn't covered by the Open Access Publishing Fee?
\n\n
If your manuscript:
\n\n
\n\t
Exceeds the number of pages defined by the publishing guidelines, an additional fee per page may be required
\n\t
If a manuscript requires Heavy Editing or Language Polishing, this will incur additional fees.
\n
\n\n
Your Author Service Manager will inform you of any items not covered by the OAPF and provide exact information regarding those additional costs before proceeding.
\n\n
Open Access Funding
\n\n
To explore funding opportunities and learn more about how you can finance your IntechOpen publication, go to our Open Access Funding page. IntechOpen offers expert assistance to all of its Authors. We can support you in approaching funding bodies and institutions in relation to publishing fees by providing information about compliance with the Open Access policies of your funder or institution. We can also assist with communicating the benefits of Open Access in order to support and strengthen your funding request and provide personal guidance through your application process. You can contact us at funders@intechopen.com for further details or assistance.
\n\n
For Authors who are still unable to obtain funding from their institutions or research funding bodies for individual projects, IntechOpen does offer the possibility of applying for a Waiver to offset some or all processing feed. Details regarding our Waiver Policy can be found here.
\n\n
Added Value of Publishing with IntechOpen
\n\n
Choosing to publish with IntechOpen ensures the following benefits:
\n\n
\n\t
Indexing and listing across major repositories, see details ...
\n\t
Long-term archiving
\n\t
Visibility on the world's strongest OA platform
\n\t
Live Performance Metrics to track readership and the impact of your chapter
\n\t
Dissemination and Promotion
\n
\n\n
Benefits of Publishing with IntechOpen
\n\n
\n\t
Proven world leader in Open Access book publishing with over 10 years experience
\n\t
+5,700 OA books published
\n\t
Most competitive prices in the market
\n\t
Fully compliant with OA funding requirements
\n\t
Optimized processes that assure your research is made available to the scientific community without delay
\n\t
Personal support during every step of the publication process
\n\t
+184,650 citations in Web of Science databases
\n\t
Currently strongest OA platform with over 175 million downloads
\n
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On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. 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After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. 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Flawed sample preparations can undermine the quality of results and lead to false conclusions. Thus, the aim of this chapter is to equip researchers, post graduate students and technicians with essential knowledge required to prepare samples for scanning electron microscopy (SEM) investigations in the life sciences.",book:{id:"5075",slug:"modern-electron-microscopy-in-physical-and-life-sciences",title:"Modern Electron Microscopy in Physical and Life Sciences",fullTitle:"Modern Electron Microscopy in Physical and Life Sciences"},signatures:"Mogana Das Murtey and Patchamuthu Ramasamy",authors:[{id:"176330",title:"Dr.",name:"Mogana",middleName:"Das",surname:"Murtey",slug:"mogana-murtey",fullName:"Mogana Murtey"},{id:"181159",title:"Mr.",name:"Patchamuthu",middleName:null,surname:"Ramasamy",slug:"patchamuthu-ramasamy",fullName:"Patchamuthu Ramasamy"}]},{id:"26791",doi:"10.5772/28067",title:"Optical Vortices in a Fiber: Mode Division Multiplexing and Multimode Self-Imaging",slug:"optical-vortices-in-a-fiber-mode-division-multiplexing-and-multimode-self-reproducing",totalDownloads:4549,totalCrossrefCites:30,totalDimensionsCites:49,abstract:null,book:{id:"2018",slug:"recent-progress-in-optical-fiber-research",title:"Recent Progress in Optical Fiber Research",fullTitle:"Recent Progress in Optical Fiber Research"},signatures:"S.N. Khonina, N.L. Kazanskiy and V.A. Soifer",authors:[{id:"72613",title:"Prof.",name:"Svetlana",middleName:null,surname:"Khonina",slug:"svetlana-khonina",fullName:"Svetlana Khonina"}]},{id:"30963",doi:"10.5772/34176",title:"Microstructural and Mineralogical Characterization of Clay Stabilized Using Calcium-Based Stabilizers",slug:"microstructural-and-mineralogical-characterization-of-clay-stabilized-using-calcium-based-stabilizer",totalDownloads:6801,totalCrossrefCites:29,totalDimensionsCites:48,abstract:null,book:{id:"1505",slug:"scanning-electron-microscopy",title:"Scanning Electron Microscopy",fullTitle:"Scanning Electron Microscopy"},signatures:"Pranshoo Solanki and Musharraf Zaman",authors:[{id:"20942",title:"Prof.",name:"Pranshoo",middleName:null,surname:"Solanki",slug:"pranshoo-solanki",fullName:"Pranshoo Solanki"},{id:"20945",title:"Prof.",name:"Musharraf",middleName:null,surname:"Zaman",slug:"musharraf-zaman",fullName:"Musharraf Zaman"}]},{id:"49655",doi:"10.5772/61830",title:"Electrical Discharge in Water Treatment Technology for Micropollutant Decomposition",slug:"electrical-discharge-in-water-treatment-technology-for-micropollutant-decomposition",totalDownloads:5019,totalCrossrefCites:32,totalDimensionsCites:44,abstract:"Hazardous micropollutants are increasingly detected worldwide in wastewater treatment plant effluent. As this indicates, their removal is insufficient by means of conventional modern water treatment techniques. In the search for a cost-effective solution, advanced oxidation processes have recently gained more attention since they are the most effective available techniques to decompose biorecalcitrant organics. As a main drawback, however, their energy costs are high up to now, preventing their implementation on large scale. For the specific case of water treatment by means of electrical discharge, further optimization is a complex task due to the wide variety in reactor design and materials, discharge types, and operational parameters. In this chapter, an extended overview is given on plasma reactor types, based on their design and materials. Influence of design and materials on energy efficiency is investigated, as well as the influence of operational parameters. The collected data can be used for the optimization of existing reactor types and for development of novel reactors.",book:{id:"5093",slug:"plasma-science-and-technology-progress-in-physical-states-and-chemical-reactions",title:"Plasma Science and Technology",fullTitle:"Plasma Science and Technology - Progress in Physical States and Chemical Reactions"},signatures:"Patrick Vanraes, Anton Y. 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The possible interferences of atomic or molecular species are used to specify organic, inorganic or biological materials which allows critical applications in defense (landmines, explosive, forensic (trace of explosive or organic materials), public health (toxic substances pharmaceutical products), or environment (organic wastes). Laser induced plasma for organic material potentially provide fast sensor systems for explosive trace and pathogen biological agent detection and analysis. The laser ablation process starts with electronic energy absorption (~fs) and ends at particle recondensation (~ms). Then, the ablation process can be governed by thermal, non-thermal processes or a combination of both. There are several types of models, i.e., thermal, mechanical, photophysical, photochemical and defect models, which describe the ablation process by one dominant mechanism only. Plasma ignition process includes bond breaking and plasma shielding during the laser pulse. Bond breaking mechanisms influence the quantity and form of energy (kinetic, ionization and excitation) that atoms and ions can acquire. Plasma expansion depends on the initial mass and energy in the plume. The process is governed by initial plasma properties (electron density, temperature, velocity) after the laser pulse and the expansion medium. During first microsecond after the laser pulse, plume expansion is adiabatic afterwards line radiation becomes the dominant mechanism of energy loss.",book:{id:"5093",slug:"plasma-science-and-technology-progress-in-physical-states-and-chemical-reactions",title:"Plasma Science and Technology",fullTitle:"Plasma Science and Technology - Progress in Physical States and Chemical Reactions"},signatures:"Kashif Chaudhary, Syed Zuhaib Haider Rizvi and Jalil Ali",authors:[{id:"176684",title:"Dr.",name:"Kashif Tufail",middleName:null,surname:"Chaudhary",slug:"kashif-tufail-chaudhary",fullName:"Kashif Tufail Chaudhary"},{id:"176867",title:"Dr.",name:"Syed Zuhaib",middleName:null,surname:"Haider Rizivi",slug:"syed-zuhaib-haider-rizivi",fullName:"Syed Zuhaib Haider Rizivi"},{id:"176868",title:"Prof.",name:"Jalil",middleName:null,surname:"Ali",slug:"jalil-ali",fullName:"Jalil Ali"}]},{id:"52164",title:"An Overview on Quantum Cascade Lasers: Origins and Development",slug:"an-overview-on-quantum-cascade-lasers-origins-and-development",totalDownloads:3255,totalCrossrefCites:2,totalDimensionsCites:11,abstract:"This chapter presents an introductory review on quantum cascade lasers (QCLs). An overview is prefaced, including a brief description of their beginnings and operating basics. Materials used, as well as growth methods, are also described. The possibility of developing GaN-based QCLs is also shown. Summarizing, the applications of these structures cover a broad range, including spectroscopy, free-space communication, as well as applications to near-space radar and chemical/biological detection. Furthermore, a number of state-of-the-art applications are described in different fields, and finally a brief assessment of the possibilities of volume production and the overall state of the art in QCLs research are elaborated.",book:{id:"5389",slug:"quantum-cascade-lasers",title:"Quantum Cascade Lasers",fullTitle:"Quantum Cascade Lasers"},signatures:"Raúl Pecharromán-Gallego",authors:[{id:"188866",title:"Dr.",name:"Raúl",middleName:null,surname:"Pecharromán-Gallego",slug:"raul-pecharroman-gallego",fullName:"Raúl Pecharromán-Gallego"}]},{id:"49526",title:"Focused Ion Beams (FIB) — Novel Methodologies and Recent Applications for Multidisciplinary Sciences",slug:"focused-ion-beams-fib-novel-methodologies-and-recent-applications-for-multidisciplinary-sciences",totalDownloads:4325,totalCrossrefCites:5,totalDimensionsCites:11,abstract:"Considered as the newest field of electron microscopy, focused ion beam (FIB) technologies are used in many fields of science for site-specific analysis, imaging, milling, deposition, micromachining, and manipulation. Dual-beam platforms, combining a high-resolution scanning electron microscope (HR-SEM) and an FIB column, additionally equipped with precursor-based gas injection systems (GIS), micromanipulators, and chemical analysis tools (such as energy-dispersive spectra (EDS) or wavelength-dispersive spectra (WDS)), serve as multifunctional tools for direct lithography in terms of nano-machining and nano-prototyping, while advanced specimen preparation for transmission electron microscopy (TEM) can practically be carried out with ultrahigh precision. Especially, when hard materials and material systems with hard substrates are concerned, FIB is the only technique for site-specific micro- and nanostructuring. Moreover, FIB sectioning and sampling techniques are frequently used for revealing the structural and morphological distribution of material systems with three-dimensional (3D) network at micro-/nanoscale.This book chapter includes many examples on conventional and novel processes of FIB technologies, ranging from analysis of semiconductors to electron tomography-based imaging of hard materials such as nanoporous ceramics and composites. In addition, recent studies concerning the active use of dual-beam platforms are mentioned",book:{id:"5075",slug:"modern-electron-microscopy-in-physical-and-life-sciences",title:"Modern Electron Microscopy in Physical and Life Sciences",fullTitle:"Modern Electron Microscopy in Physical and Life Sciences"},signatures:"Meltem Sezen",authors:[{id:"176338",title:"Associate Prof.",name:"Meltem",middleName:null,surname:"Sezen",slug:"meltem-sezen",fullName:"Meltem Sezen"}]},{id:"50866",title:"Effects of Different Laser Pulse Regimes (Nanosecond, Picosecond and Femtosecond) on the Ablation of Materials for Production of Nanoparticles in Liquid Solution",slug:"effects-of-different-laser-pulse-regimes-nanosecond-picosecond-and-femtosecond-on-the-ablation-of-ma",totalDownloads:6112,totalCrossrefCites:11,totalDimensionsCites:36,abstract:"Ultra-short laser pulse interaction with materials has received much attention from researchers in micro- and nanomachining, especially for the generation of nanoparticles in liquid environments, because of the straightforward method and direct application for organic solvents. In addition, the colloidal nanoparticles produced by laser ablation have very high purity—they are free from surfactants and reaction products or by-products. In this chapter, nanosecond, picosecond and femtosecond laser pulse durations are compared in laser material processing. Due to the unique properties of the short and ultra-short laser pulse durations in material processing, they are more apparent in the production of precision material processing and generation of nanoparticles in liquid environments.",book:{id:"5236",slug:"high-energy-and-short-pulse-lasers",title:"High Energy and Short Pulse Lasers",fullTitle:"High Energy and Short Pulse Lasers"},signatures:"Abubaker Hassan Hamad",authors:[{id:"183494",title:"Dr.",name:"Abubaker",middleName:"Hassan",surname:"Hamad",slug:"abubaker-hamad",fullName:"Abubaker Hamad"}]},{id:"49537",title:"Electron Diffraction",slug:"electron-diffraction",totalDownloads:10155,totalCrossrefCites:11,totalDimensionsCites:33,abstract:"Electron microscopes are usually supplied with equipment for obtaining diffraction patterns and micrographs from the same area of a specimen and the best results are attained if the complete use is to be made of these combined facilities. Electron diffraction patterns are used to obtain quantitative data including phase identification, orientation relationship and crystal defects in materials, etc. At first, a general introduction including a geometrical and quantitative approach to electron diffraction from a crystalline specimen, the reciprocal lattice and electron diffraction in the electron microscope are presented. The scattering process by an individual atom as well as a crystal, the Bragg law, Laue conditions and structure factor are also discussed. Types of diffraction patterns such as ring pattern, spot pattern and Kikuchi pattern, and general and unique indexing diffraction patterns are explained. The procedure for indexing simple, complicated and imperfect patterns as well as Kikuchi lines and a combination of Kikuchi lines and spots is outlined. The known and unknown materials are identified by indexing patterns. Practical comparisons between various methods of analysing diffraction patterns are also described. The basic diffraction patterns and the fine structure in the patterns including specimen tilting experiments, orientation relationship determination, phase identification, twinning, second phases, crystallographic information, dislocation, preferred orientation and texture, extra spots and streaks are described in detail. Finally, electron diffraction patterns of new materials are investigated.",book:{id:"5075",slug:"modern-electron-microscopy-in-physical-and-life-sciences",title:"Modern Electron Microscopy in Physical and Life Sciences",fullTitle:"Modern Electron Microscopy in Physical and Life Sciences"},signatures:"Mohsen Asadi Asadabad and Mohammad Jafari Eskandari",authors:[{id:"176352",title:"Dr.",name:"Mohsen",middleName:null,surname:"Asadi Asadabad",slug:"mohsen-asadi-asadabad",fullName:"Mohsen Asadi Asadabad"},{id:"177600",title:"Dr.",name:"Mohammad",middleName:null,surname:"Jafari Eskandari",slug:"mohammad-jafari-eskandari",fullName:"Mohammad Jafari Eskandari"}]}],onlineFirstChaptersFilter:{topicId:"20",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"82973",title:"Compact Incoherent Multidimensional Imaging Systems Using Static Diffractive Coded Apertures",slug:"compact-incoherent-multidimensional-imaging-systems-using-static-diffractive-coded-apertures",totalDownloads:1,totalDimensionsCites:0,doi:"10.5772/intechopen.105864",abstract:"Incoherent holographic imaging technologies, in general, involve multiple optical components for beam splitting—combining and shaping—and in most cases, require an active optical device such as a spatial light modulator (SLM) for generating multiple phase-shifted holograms in time. The above requirements made the realization of holography-based products expensive, heavy, large, and slow. To successfully transfer the holography capabilities discussed in research articles to products, it is necessary to find methods to simplify holography architectures. In this book chapter, two important incoherent holography techniques, namely interference-based Fresnel incoherent correlation holography (FINCH) and interferenceless coded aperture correlation holography (I-COACH), have been successfully simplified in space and time using advanced manufacturing methods and nonlinear reconstruction, respectively. Both techniques have been realized in compact optical architectures using a single static diffractive optical element manufactured using lithography technologies. Randomly multiplexed diffractive lenses were manufactured using electron beam lithography for FINCH. A quasi-random lens and a mask containing a quasi-random array of pinholes were manufactured using electron beam lithography and photolithography, respectively, for I-COACH. In both cases, the compactification has been achieved without sacrificing the performances. The design, fabrication, and experiments of FINCH and I-COACH with static diffractive optical elements are presented in details.",book:{id:"11860",title:"Holography - Recent Advances and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/11860.jpg"},signatures:"Vijayakumar Anand, Soon Hock Ng, Tomas Katkus, Daniel Smith, Vinoth Balasubramani, Denver P. Linklater, Pierre J. Magistretti, Christian Depeursinge, Elena P. Ivanova and Saulius Juodkazis"},{id:"82958",title:"Electromagnetic Relations between Materials and Fields for Microwave Chemistry",slug:"electromagnetic-relations-between-materials-and-fields-for-microwave-chemistry",totalDownloads:2,totalDimensionsCites:0,doi:"10.5772/intechopen.106257",abstract:"We consider the application of microwave energy to a material. The effects of the electromagnetic field on the material and of the material on the electromagnetic field will be described, focusing on the dielectric relaxation phenomenon of the liquid. The dielectric permittivity of mixtures is discussed by extending Debye relaxation to explain how the material behaves with respect to an electric field. We will also consider the energy that the electric field imparts to the material, both thermally and nonthermally. We will develop this relation and describe what form it should take if there is a nonthermal effect in the chemical reaction field under microwave irradiation.",book:{id:"11494",title:"Electric Field in Advancing Science and Technology",coverURL:"https://cdn.intechopen.com/books/images_new/11494.jpg"},signatures:"Sugiyama Jun-ichi, Sugiyama Hayato, Sato Chika and Morizumi Maki"},{id:"82961",title:"Mixed Reality Applications in Business Contexts",slug:"mixed-reality-applications-in-business-contexts",totalDownloads:3,totalDimensionsCites:0,doi:"10.5772/intechopen.106582",abstract:"Mixed reality is becoming increasingly relevant in business. In the corporate environment, such as logistics or maintenance, the use of data glasses allows extensive possibilities for process optimization and quality assurance. In the area of construction, virtual models either as augmentation of reality or mapped in virtual reality offer new approaches to experience ability. The goal of this paper is to show the manifold possibilities of mixed reality in the enterprise environment. For this purpose, selected application scenarios with corresponding realization stages will be shown and analyzed regarding their added value.",book:{id:"11860",title:"Holography - Recent Advances and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/11860.jpg"},signatures:"Anett Mehler-Bicher, Lothar Steiger and Dirk Weitzel"},{id:"82951",title:"Decoupling Techniques for Coupled PDE Models in Fluid Dynamics",slug:"decoupling-techniques-for-coupled-pde-models-in-fluid-dynamics",totalDownloads:2,totalDimensionsCites:0,doi:"10.5772/intechopen.105997",abstract:"We review decoupling techniques for coupled PDE models in fluid dynamics. In particular, we are interested in the coupled models for fluid flow interacting with porous media flow and the fluid structure interaction (FSI) models. For coupled models for fluid flow interacting with porous media flow, we present decoupled preconditioning techniques, two-level and multilevel methods, Newton-type linearization-based two-level and multilevel algorithms, and partitioned time-stepping methods. The main theory and some numerical experiments are given to illustrate the effectiveness and efficiency of these methods. For the FSI models, partitioned time-stepping algorithms and a multirate time-stepping algorithm are carefully studied and analyzed. Numerical experiments are presented to highlight the advantages of these methods.",book:{id:"11862",title:"The Essence of Large-Eddy Simulations",coverURL:"https://cdn.intechopen.com/books/images_new/11862.jpg"},signatures:"Mingchao Cai, Mo Mu and Lian Zhang"},{id:"82787",title:"Spinor Fields",slug:"spinor-fields",totalDownloads:4,totalDimensionsCites:0,doi:"10.5772/intechopen.105569",abstract:"A spinor representation of the generalized energy-momentum density 4-vector is proposed, and examples of such representations for various particles and fields are given. This representation corresponds to the classical representation of the particle’s own rotation, which is described by the diagonal matrix of the moment of inertia. The concept of self-angular rotation of a particle is defined as a spatial characteristic of the field, at each point of which there is a local vortex rotation with an angular velocity Ω – a spinor field. The matrix representation of the vortex rotation Ω (spinor) and the values of the components of such a representation are derived from the matrix representation of the Lorentz transformation. The traditional concept of spin-orbit interaction, as the interaction of the magnetic moment of a particle with the magnetic field of orbital motion, is presented as the interaction of a charged particle with a spinor field. Solutions to the problems of particle motion in an external spinor field in the case of a hydrogen-like atom and planetary motion, splitting of the electron energy levels of an atom in an external magnetic field, deflection of a photon by the gravitational field, and representations in metric spaces are presented.",book:{id:"11496",title:"Quantum Field Theory",coverURL:"https://cdn.intechopen.com/books/images_new/11496.jpg"},signatures:"Vahram Mekhitarian"},{id:"82739",title:"Experimental Breeder Reactor II",slug:"experimental-breeder-reactor-ii",totalDownloads:11,totalDimensionsCites:0,doi:"10.5772/intechopen.105800",abstract:"The Experimental Breeder Reactor II (EBR-II) operated from 1964 to 1994. EBR-II was a sodium-cooled fast reactor operating at 69 MWth producing 19 MWe. Rather than using a loop approach for the coolant, EBR-II used a pool arrangement where the reactor core, primary coolant piping, and primary reactor coolant pumps were contained within the pool of sodium. Also contained within the pool was a heat exchanger where primary coolant, which is radioactive, transferred heat to secondary, nonradioactive, sodium. The nuclear power plant included a sodium boiler building where heat from the secondary sodium generated superheated steam, which was delivered to a turbine/generator for electricity production. EBR-II fuel was metallic uranium alloyed with various metals providing significant performance and safety enhancements over oxide fuel. The most significant EBR-II experiments occurred in April 1986. Relying on inherent physical properties of the reactor, two experiments were performed subjecting the reactor to loss of primary coolant flow without reactor SCRAM and loss of the secondary system heat removal without reactor SCRAM. In both experiments, the reactor experienced no damage. This chapter provides a description of the most important design features of EBR-II along with a summary of the landmark reactor safety experiments.",book:{id:"10982",title:"Nuclear Reactors - Spacecraft Propulsion, Research Reactors, and Reactor Analysis Topics",coverURL:"https://cdn.intechopen.com/books/images_new/10982.jpg"},signatures:"Chad L. 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The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"24",title:"Sustainable Development",doi:"10.5772/intechopen.100361",issn:"2753-6580",scope:"
\r\n\tTransforming our World: the 2030 Agenda for Sustainable Development endorsed by United Nations and 193 Member States, came into effect on Jan 1, 2016, to guide decision making and actions to the year 2030 and beyond. Central to this Agenda are 17 Goals, 169 associated targets and over 230 indicators that are reviewed annually. The vision envisaged in the implementation of the SDGs is centered on the five Ps: People, Planet, Prosperity, Peace and Partnership. This call for renewed focused efforts ensure we have a safe and healthy planet for current and future generations.
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\r\n\tThis Series focuses on covering research and applied research involving the five Ps through the following topics:
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\r\n\t1. Sustainable Economy and Fair Society that relates to SDG 1 on No Poverty, SDG 2 on Zero Hunger, SDG 8 on Decent Work and Economic Growth, SDG 10 on Reduced Inequalities, SDG 12 on Responsible Consumption and Production, and SDG 17 Partnership for the Goals
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\r\n\t2. Health and Wellbeing focusing on SDG 3 on Good Health and Wellbeing and SDG 6 on Clean Water and Sanitation
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\r\n\t3. Inclusivity and Social Equality involving SDG 4 on Quality Education, SDG 5 on Gender Equality, and SDG 16 on Peace, Justice and Strong Institutions
\r\n
\r\n\t
\r\n
\r\n\t4. Climate Change and Environmental Sustainability comprising SDG 13 on Climate Action, SDG 14 on Life Below Water, and SDG 15 on Life on Land
\r\n
\r\n\t
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\r\n\t5. Urban Planning and Environmental Management embracing SDG 7 on Affordable Clean Energy, SDG 9 on Industry, Innovation and Infrastructure, and SDG 11 on Sustainable Cities and Communities.
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\r\n\tThe series also seeks to support the use of cross cutting SDGs, as many of the goals listed above, targets and indicators are all interconnected to impact our lives and the decisions we make on a daily basis, making them impossible to tie to a single topic.
",coverUrl:"https://cdn.intechopen.com/series/covers/24.jpg",latestPublicationDate:"August 2nd, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:1,editor:{id:"262440",title:"Prof.",name:"Usha",middleName:null,surname:"Iyer-Raniga",slug:"usha-iyer-raniga",fullName:"Usha Iyer-Raniga",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRYSXQA4/Profile_Picture_2022-02-28T13:55:36.jpeg",biography:"Usha Iyer-Raniga is a professor in the School of Property and Construction Management at RMIT University. Usha co-leads the One Planet Network’s Sustainable Buildings and Construction Programme (SBC), a United Nations 10 Year Framework of Programmes on Sustainable Consumption and Production (UN 10FYP SCP) aligned with Sustainable Development Goal 12. The work also directly impacts SDG 11 on Sustainable Cities and Communities. She completed her undergraduate degree as an architect before obtaining her Masters degree from Canada and her Doctorate in Australia. Usha has been a keynote speaker as well as an invited speaker at national and international conferences, seminars and workshops. Her teaching experience includes teaching in Asian countries. She has advised Austrade, APEC, national, state and local governments. She serves as a reviewer and a member of the scientific committee for national and international refereed journals and refereed conferences. She is on the editorial board for refereed journals and has worked on Special Issues. Usha has served and continues to serve on the Boards of several not-for-profit organisations and she has also served as panel judge for a number of awards including the Premiers Sustainability Award in Victoria and the International Green Gown Awards. Usha has published over 100 publications, including research and consulting reports. Her publications cover a wide range of scientific and technical research publications that include edited books, book chapters, refereed journals, refereed conference papers and reports for local, state and federal government clients. She has also produced podcasts for various organisations and participated in media interviews. She has received state, national and international funding worth over USD $25 million. Usha has been awarded the Quarterly Franklin Membership by London Journals Press (UK). Her biography has been included in the Marquis Who's Who in the World® 2018, 2016 (33rd Edition), along with approximately 55,000 of the most accomplished men and women from around the world, including luminaries as U.N. Secretary-General Ban Ki-moon. In 2017, Usha was awarded the Marquis Who’s Who Lifetime Achiever Award.",institutionString:null,institution:{name:"RMIT University",institutionURL:null,country:{name:"Australia"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:5,paginationItems:[{id:"91",title:"Sustainable Economy and Fair Society",coverUrl:"https://cdn.intechopen.com/series_topics/covers/91.jpg",isOpenForSubmission:!0,annualVolume:11975,editor:{id:"181603",title:"Dr.",name:"Antonella",middleName:null,surname:"Petrillo",slug:"antonella-petrillo",fullName:"Antonella Petrillo",profilePictureURL:"https://mts.intechopen.com/storage/users/181603/images/system/181603.jpg",biography:"Antonella Petrillo, Ph.D., is a professor in the Department of Engineering, University of Naples “Parthenope,” Italy. She received her Ph.D. in Mechanical Engineering from the University of Cassino and Southern Lazio, Italy. Her research interests include multi-criteria decision analysis, industrial plants, logistics, manufacturing, and safety. She serves as an associate editor for the International Journal of the Analytic Hierarchy Process and is an editorial board member for several other journals. 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She is regularly invited as a keynote speaker at conferences. She is a guest editor for several special issues and a member of the editorial board of several scientific journals. She has published more than 200 articles and is currently working on book projects in the field of OFDL. Ossiannilsson is a visiting professor at several international universities and was recently appointed Professor and Research Fellow at Victoria University of Wellington, NZ. Ossiannilsson has been awarded the following fellowships: EDEN Fellows, EDEN Council of Fellows, and Open Education Europe. She is a ICDE OER Ambassador, Open Education Europe Ambassador, GIZ Ambassador for Quality in Digital Learning, and part of the Globe-Community of Digital Learning and Champion of SPARC Europe. On a national level, she is a quality developer at the Swedish Institute for Standards (SIS) and for ISO. She is a member of the Digital Skills and Jobs Coalition Sweden and Vice President of the Swedish Association for Distance Education. She is currently working on a government initiative on quality in distance education at the National Council for Higher Education. She holds a Ph.D. from the University of Oulu, Finland.",institutionString:"Swedish Association for Distance Education, Sweden",institution:null},editorTwo:null,editorThree:null},{id:"94",title:"Climate Change and Environmental Sustainability",coverUrl:"https://cdn.intechopen.com/series_topics/covers/94.jpg",isOpenForSubmission:!0,annualVolume:11978,editor:{id:"61855",title:"Dr.",name:"Yixin",middleName:null,surname:"Zhang",slug:"yixin-zhang",fullName:"Yixin Zhang",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYWJgQAO/Profile_Picture_2022-06-09T11:36:35.jpg",biography:"Professor Yixin Zhang is an aquatic ecologist with over 30 years of research and teaching experience in three continents (Asia, Europe, and North America) in Stream Ecology, Riparian Ecology, Urban Ecology, and Ecosystem Restoration and Aquatic Conservation, Human-Nature Interactions and Sustainability, Urbanization Impact on Aquatic Ecosystems. He got his Ph.D. in Animal Ecology at Umeå University in Sweden in 1998. He conducted postdoc research in stream ecology at the University of California at Santa Barbara in the USA. After that, he was a postdoc research fellow at the University of British Columbia in Canada to do research on large-scale stream experimental manipulation and watershed ecological survey in temperate rainforests of BC. He was a faculty member at the University of Hong Kong to run ecological research projects on aquatic insects, fishes, and newts in Tropical Asian streams. He also conducted research in streams, rivers, and caves in Texas, USA, to study the ecology of macroinvertebrates, big-claw river shrimp, fish, turtles, and bats. Current research interests include trophic flows across ecosystems; watershed impacts of land-use change on biodiversity and ecosystem functioning; ecological civilization and water resource management; urban ecology and urban/rural sustainable development.",institutionString:null,institution:{name:"Soochow University",institutionURL:null,country:{name:"China"}}},editorTwo:null,editorThree:null},{id:"95",title:"Urban Planning and Environmental Management",coverUrl:"https://cdn.intechopen.com/series_topics/covers/95.jpg",isOpenForSubmission:!0,annualVolume:11979,editor:{id:"181079",title:"Dr.",name:"Christoph",middleName:null,surname:"Lüthi",slug:"christoph-luthi",fullName:"Christoph Lüthi",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRHSqQAO/Profile_Picture_2022-04-12T15:51:33.png",biography:"Dr. Christoph Lüthi is an urban infrastructure planner with over 25 years of experience in planning and design of urban infrastructure in middle and low-income countries. 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Since 2015 he heads the research department Sanitation, Water and Solid Waste for Development (Sandec) at the Swiss Federal Institute of Aquatic Research and Technology (Eawag).",institutionString:"Swiss Federal Institute of Aquatic Science and Technology, Switzerland",institution:{name:"Swiss Federal Institute of Aquatic Science and Technology",institutionURL:null,country:{name:"Switzerland"}}},editorTwo:{id:"290571",title:"Dr.",name:"Rui Alexandre",middleName:null,surname:"Castanho",slug:"rui-alexandre-castanho",fullName:"Rui Alexandre Castanho",profilePictureURL:"https://mts.intechopen.com/storage/users/290571/images/system/290571.jpg",biography:"Rui Alexandre Castanho has a master\\'s degree in Planning, Audit, and Control in Urban Green Spaces and an international Ph.D. in Sustainable Planning in Borderlands. Currently, he is a professor at WSB University, Poland, and a visiting professor at the University of Johannesburg, South Africa. Dr. Castanho is a post-doc researcher on the GREAT Project, University of Azores, Ponta Delgada, Portugal. He collaborates with the Environmental Resources Analysis Research Group (ARAM), University of Extremadura (UEx), Spain; VALORIZA - Research Center for the Enhancement of Endogenous Resources, Polytechnic Institute of Portalegre (IPP), Portugal; Centre for Tourism Research, Development and Innovation (CITUR), Madeira, Portugal; and AQUAGEO Research Group, University of Campinas (UNICAMP), Brazil.",institutionString:"University of Johannesburg, South Africa and WSB University, Poland",institution:{name:"University of Johannesburg",institutionURL:null,country:{name:"South Africa"}}},editorThree:null}]},overviewPageOFChapters:{paginationCount:9,paginationItems:[{id:"82936",title:"Soil Degradation Processes Linked to Long-Term Forest-Type Damage",doi:"10.5772/intechopen.106390",signatures:"Pavel Samec, Aleš Kučera and Gabriela Tomášová",slug:"soil-degradation-processes-linked-to-long-term-forest-type-damage",totalDownloads:2,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Forest Degradation Under Global Change",coverURL:"https://cdn.intechopen.com/books/images_new/11457.jpg",subseries:{id:"94",title:"Climate Change and Environmental Sustainability"}}},{id:"82777",title:"Sustainability and Social Investment: Community Microhydropower Systems in the Dominican Republic",doi:"10.5772/intechopen.105995",signatures:"Michela Izzo, Alberto Sánchez and Rafael Fonseca",slug:"sustainability-and-social-investment-community-microhydropower-systems-in-the-dominican-republic",totalDownloads:4,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Globalization and Sustainability - Recent Advances, New Perspectives and Emerging Issues",coverURL:"https://cdn.intechopen.com/books/images_new/11476.jpg",subseries:{id:"91",title:"Sustainable Economy and Fair Society"}}},{id:"82387",title:"Kept Promises? The Evolution of the EU Financial Contribution to Climate Change",doi:"10.5772/intechopen.105541",signatures:"Cecilia Camporeale, Roberto Del Ciello and Mario Jorizzo",slug:"kept-promises-the-evolution-of-the-eu-financial-contribution-to-climate-change",totalDownloads:11,totalCrossrefCites:0,totalDimensionsCites:0,authors:[{name:"Mario",surname:"Jorizzo"},{name:"Cecilia",surname:"Camporeale"},{name:"ROBERTO",surname:"DEL CIELLO"}],book:{title:"Globalization and Sustainability - Recent Advances, New Perspectives and Emerging Issues",coverURL:"https://cdn.intechopen.com/books/images_new/11476.jpg",subseries:{id:"91",title:"Sustainable Economy and Fair Society"}}},{id:"82524",title:"Italy’s Small Exporting Companies: Globalization and Sustainability Issues",doi:"10.5772/intechopen.105542",signatures:"Roberta Pace and Francesca Mandanici",slug:"italy-s-small-exporting-companies-globalization-and-sustainability-issues",totalDownloads:13,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Globalization and Sustainability - Recent Advances, New Perspectives and Emerging Issues",coverURL:"https://cdn.intechopen.com/books/images_new/11476.jpg",subseries:{id:"91",title:"Sustainable Economy and Fair Society"}}}]},overviewPagePublishedBooks:{paginationCount:1,paginationItems:[{type:"book",id:"10897",title:"Food Systems Resilience",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/10897.jpg",slug:"food-systems-resilience",publishedDate:"July 13th 2022",editedByType:"Edited by",bookSignature:"Ana I. 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