Confusion matrix describing the four events that can happen in the binary test performed by the acquisition process.
\r\n\tThere are generally two types of masonry: brick and stone masonry. Brick masonry: a type of masonry that uses bricks. However, masonry is further divided into "clay work," which uses clay to fill various joints with bricks to build walls, and "cement masonry," the cheapest type of masonry. Masonry: this is the art of building with bricks or stone. The ability of masonry to support the load imposed by the structural elements above it is called strength. The application of loads to masonry creates internal stresses and deformations. The brand of mortar and brick, the shape and size of masonry materials, and the thickness and density of mortar joints affect the strength of masonry. The ability of masonry to maintain its position under horizontal load is called stability. This property limits the height of masonry depending on its thickness and the magnitude of wind loads. The thermal conductivity of bricks of different types (silicate, ceramic, facing, refractory) is considered. A comparison of bricks in terms of their thermal conductivity is made; the thermal conductivity coefficients of refractory bricks are presented at different temperatures - from 20 to 1700°C. The thermal conductivity depends mainly on the density and the configuration of the voids. Architecture and construction consist of various elements for building works, and masonry is the main element with which these constructions are realized. Masonry is a piece of fired clay with a rectangular shape and is used to build walls and structures. Nowadays, eco-masonry can be made of different materials that offer a variety of advantages, but all of them offer benefits at the level of the environment and sustainability; some of these utensils are plastic bottles, clay, etc. The book addresses the holistic issue of using modern masonry in construction. This book interprets masonry as an essential theme of contemporary architecture and sustainable construction. It is one of the most valuable materials in the history of mankind.
",isbn:"978-1-83768-126-6",printIsbn:"978-1-83768-125-9",pdfIsbn:"978-1-83768-127-3",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,isNomenclature:!1,hash:"85ef86d046d15e7d4b1988f1ec5dd750",bookSignature:"Prof. Amjad Almusaed and Prof. Asaad Almssad",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/12061.jpg",keywords:"Unreinforced Masonry Buildings, Masonry in Sustainable Building, Energy Saving and Masonry, Eco-Friendly Masonry, Modern Architecture and Masonry, Masonry and Human Behavior, Esthetic and Masonry, History of Advanced Masonry, Structural Masonry, Modeling of Masonry Structures, Modern Masonry Manufacturing, Masonry Walls",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"May 20th 2022",dateEndSecondStepPublish:"July 21st 2022",dateEndThirdStepPublish:"September 19th 2022",dateEndFourthStepPublish:"December 8th 2022",dateEndFifthStepPublish:"February 6th 2023",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"a month",secondStepPassed:!0,areRegistrationsClosed:!1,currentStepOfPublishingProcess:3,editedByType:null,kuFlag:!1,biosketch:"Prof. Amjad Almusaed, affiliated with Jönköping University has carried out a great deal of research and technical survey work and has performed several studies in these areas. 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Fast electronics, complex modulation schemes and correction codes enable transmissions on channels with unfavorable characteristics, coexistence between different services in the same frequency bands and high transmission rates. However, the complexity of such communications systems often prevents analytical characterizations. For example, figures of merit such as the BER are difficult to determine analytically for transmission schemes involving correction codes and communication channels with ISI and fading. In such cases, the system is characterized through Monte Carlo simulations [1, 2]. The Monte Carlo framework involves simulations of the whole system under analysis. For example, when considering a communications system, the whole transmission-reception chain is simulated. A large number of sequences are sent through the simulated system and the message recovered by the simulated receiver is compared to the original transmitted sequence. This comparison allows one to determine the average number of transmission errors and compute the BER.
Monte Carlo simulations can be applied to almost any system although their implementation and computation requirements can be significantly high. In addition to this, precision problems can arise when the quantity to be estimated is significantly low. For example, BER of the order of
In order to overcome the limitation of Monte Carlo and analytical techniques, semi-analytic approaches have been previously implemented [2, 1]. In a semi-analytic framework, the knowledge of the system under analysis is exploited to reduce the computational load and complexity that full Monte Carlo simulations would require. In this way, the strengths of both analytical and Monte Carlo methods are effectively combined. Semi-analytic techniques are a powerful tool for the analysis of complex systems.
The characteristics and relationships among the three aforementioned methods are shown in Figure 1 : semi-analytic approaches represent a good compromise in terms of applicability and complexity, combining the strengths of Monte Carlo and analytical approaches.
Different approaches available for the analysis of complex systems. Semi-analytic approaches represent a compromise in terms of applicability and complexity (computational and implementation) between analytical models and Monte Carlo simulations.
The main goal of this chapter is to provide a general overview of semi-analytic techniques for the simulation of communications systems. Specific emphasis is given to their implementation in MT and two examples from the communications context are analyzed in detail.
Despite their potential, semi-analytic techniques have received limited attention from the communications community. Reference books on simulation of communications systems such as [1], [2] and [3] dedicate only a few pages to this kind of techniques. The focus is usually on the computation of the BER, which represents one of the first applications of semi-analytic techniques in communication system analysis [4, 5]. In this case, the model depicted in Figure 2 is adopted. The communications channel is modeled as a non-linear device, which distorts the signal component alone, with the addition of a noise term that is assumed to be Gaussian. This model is quite general and can be used to represent several communications channels.
Model adopted for the evaluation of the BER using a semi-analytic approach. The communications channel is modeled as a non-linear device, which affects only the signal component, and the addition of a noise term supposed to be Gaussian.
A classical example is the model of a transmission chain where a TWTA is used to amplify the useful signal before transmission. The TWTA is highly non-linear and can lead to signal distortions. Since the signal is injected into the TWTA before transmission, the noise component entering the amplifier is negligible. In this case, the model depicted in Figure 2 is appropriate for describing the transmission chain including a non-linear amplifier.
The TWTA is a memory-less device and can be characterized using
In the semi-analytic framework, the additivity of the noise component is exploited to compute the BER. More specifically, only the signal transmission chain is simulated and for each possible signal symbol, the Eb is computed. Since the noise properties are known, the BER for the
where
where
This simple example clearly illustrates the principles of semi-analytic techniques: the analytical knowledge of the system is exploited to reduce the computation load and complexity that full Monte Carlo simulations would require. In this case, only the transmission of the signal component is simulated.
In the literature, several generalizations of the aforementioned BER computation technique have been proposed. For example, [5] considered the case where the noise term at the input of the non-linear amplifier is not negligible. An equivalent model is proposed where the noise at the input is propagated after the non-linearity. [5] also considered the presence of a bandpass channel. More recently, [6] proposed a methodology for estimating the BER in the presence of ISI. All these examples show the potential and flexibility of the semi-analytic approach.
When considering the previous example it is possible to identify three building blocks that play different roles in the semi-analytic framework:
simulation block
estimation block
analytical model.
The simulation block corresponds to that part of the system that is actually simulated. In the previous example, this block corresponds to the signal generation, the non-linear amplifier and the correlation receiver simulation. These blocks were used to determine the decision variable employed for recovering the transmitted symbol. The analytical model exploits the properties of the system to determine the quantities of interest. In the previous example, the fact that the noise introduced by the communication channel is Gaussian was exploited to determine the BER as a function of the Eb of each transmitted symbol. The estimation block is used as the interface between the simulated and analytical parts of the system. In BER computation case, the simulation part allows one to generate the different decision variables, whereas the analytical model is expressed as a function of energy per bit. The estimation block is used to determine Eb from the simulated decision variables.
The three functional blocks can be connected according to different configurations leading to different types of semi-analytic approaches. In the next section, two of these configurations are briefly discussed. Examples for each type of semi-analytic system are given in Section 2 and Section 3.
When considering the BER example, it is possible to note that the simulation, estimation and analytical blocks are connected in series. The simulation block is used at first to compute the different decision variables. The estimation block determines the Eb associated with each variable and finally the analytical model is used to compute the BER from the EN0.
This type of configuration is defined here as
Basic blocks and main configurations adopted in semi-analytic approaches. An estimation block is used for determining key signal and system parameters and interfacing the simulation and analytic components of the system.
A second type of configuration has been recently considered for the analysis of tracking loops in DSSS and GNSS receivers. The most computationally demanding operation in a DSSS/GNSS receiver is despreading, i.e, the correlation of the incoming samples with local replicas of the code and carrier. This operation is performed by the ID blocks that rely on simple operations that can be analytically modeled. For this reason, semi-analytic models exploiting the knowledge of the ID blocks and simulating only the non-linear parts of the system have been developed [7, 8, 9, 10]. This resulted in efficient analysis tools, which require reduced processing time with the applicability of Monte Carlo simulations.
Different techniques for modeling the output of the ID have been suggested. [7] modeled the correlator outputs evaluated by the ID blocks as linear combinations of independent Gaussian random variables. Correlation among the different correlators was obtained by using, for the generation of different ID outputs, a subset of the same random variables. This technique becomes complex as the number of correlators increases. Another attempt made in [8] assumed that the correlator outputs were independent which, in general, is not a realistic condition. Finally, [9, 10] suggested the use of a technique based on the Cholesky decomposition detailed in [11]. This approach allows one to easily generate an arbitrary number of correlated Gaussian random variables. In this way, [9, 10] were able to simulate advanced tracking loops for new GNSS signals.
Regardless of the type of approach used for modeling the correlator outputs, the aforementioned semi-analytic configuration can be represented as in the bottom part of Figure 3. In this case, an analytical model is used to generate quantities that will be propagated by simulation. In the tracking loop case, an analytical model is used to generate the correlator outputs that are then processed through simulations. The non-linear parts of the system are fully simulated and quantities such as the loop discriminator and filter outputs are computed. Finally, an estimation block is used to interface the simulation and analytical components of the semi-analytic scheme. A new estimate of the signal parameters is obtained and used to generate new correlator outputs. The estimation block is also used to compute performance metrics such as tracking jitter or MTLL [12].
The three functional blocks described in Section 1.1 are connected in a loop and thus this type of configuration is named
As shown in Figure 3, the sequential approach, at first, requires an initial simulation block to generate the random processes and system functions that cannot be analytically described. Subsequently, the simulated processes are employed by the estimation unit to obtain key parameters required by the analytical model to compute metrics of interest. In the analytical model, the estimated parameters are plugged into mathematical expressions to obtain the desired final metrics. In the sequential architecture, the gain in computational load mainly depends on the simplifications allowed by the analytical model. The use of such a model allows one to simulate only a part of the system and eventually avoid computationally demanding error counting processes.
The computational complexity of Monte Carlo simulations increases significantly when two or more communication systems coexist within the same environment. In this case, it is necessary to account for the interaction of the different systems and determine potential inter-system interference. In addition, computational requirements of Monte Carlo simulations increase dramatically with the number of random elements included in each block of the communication chain. These requirements can be considerably reduced by adopting semi-analytic techniques in which the evaluated metrics are analytically expressed as a function of parameters estimated through simulations. This principle is the core idea behind the sequential semi-analytic approach.
In order to better illustrate the principles of the semi-analytic sequential approach, an inter-system interference scenario is considered in this section. The case of a satellite navigation receiver affected by interference generated by a communications system is considered. The primary system (i.e., the victim system) considered here is a GPS L1 receiver affected by an interference signal caused by third order harmonics of a DVB-T signal. A comprehensive description of the sequential approach applied to an inter-system interference case is provided in the following.
The reception of GNSS signals is challenging due to low signal power, possible severe channel conditions and the presence of RF interference. The presence of RF interference can be particularly troublesome and the performance of a GNSS receiver can vary significantly depending on the type of interference. For this reason, significant research efforts have been devoted to the characterization of the receiver performance in the presence of different types of interference [13, 14]. Furthermore, the impact of interference originated by specific communication technologies, such as UWB transmissions [15], DME signals [16] and DVB-T harmonics [17, 18], has been thoroughly investigated. It is noted that the interference impact strongly depends on the strategy adopted by a GNSS receiver for processing the useful signals. Moreover, different impacts are expected depending on the receiver operating mode. The first task of a GNSS receiver is to determine the presence of a specific GNSS signal. This task is accomplished by the acquisition block that implements a statistical test for the detection of useful signals. After acquisition, the useful GNSS signals are passed to the tracking stage that refines the estimates of different signal parameters. Since acquisition and tracking implement different processing strategies, RF interference will affect these two receiver blocks differently. In the following, the acquisition stage is considered. A semi-analytic approach for the analysis of GNSS tracking loops is discussed in Section 3.
The acquisition of a GNSS signal can be formulated as a classical detection problem [19], where the signal of interest is buried in noise. The outcome of the acquisition process is twofold. First, a decision relative to the signal presence is provided. If the signal is present, a rough estimate of signal parameters (defined in the following) is also obtained. The received useful GNSS signal, which is impaired by AWGN and interference, is processed by the acquisition block yielding a decision variable. If the decision variable is greater than a decision threshold the signal presence is declared. This decision variable is calculated by using the digital samples provided by the receiver front-end. The signal model and the acquisition process are briefly summarized in the following sections.
The signal at the input of a GNSS receiver, in a one-path AWGN channel and in the presence of RF interference, can be modeled as
where
Each useful signal,
where
It is noted that GNSS signals adopt a DSSS modulation. The pseudo-random sequences,
The pseudo-random sequence,
The signal
A GNSS receiver is able to process the
where the index
The received signal in (6) is filtered and down-converted by the receiver front-end. Filtering is of particular importance since it determines which portion of the interfering signal,
where the notation
The noise term,
The interference term in (6),
where
Third order harmonics are the consequence of the malfunctioning of the transmitter electronics. In particular, the presence of these harmonics are due to the non-linearities of an amplifier. The output of an amplifier can be modeled using a polynomial expansion of the amplifier input/output function:
where
The terms of order
The signal
Finally, the interference term in (7) can be modeled as
After signal conditioning, the sequence
Schematic representation of the operations performed by the acquisition block of a GNSS receiver.
where
where
It is noted that, as in any binary test, two hypotheses are possible:
The null hypothesis,
Furthermore,
Depending on the result of the test,
and the four events described in Table 1 can occur.
Signal absence correctly declared | False alarm | |
Missed detection | Signal detection |
Confusion matrix describing the four events that can happen in the binary test performed by the acquisition process.
The off-diagonal events in Table 1 correspond to the different errors that the acquisition block can commit. The following probabilities are usually associated with the events in Table 1 :
and
The probabilities of missed detection and correct signal absence decision are obtained as
The goal of the sequential semi-analytic approach considered in this section is the evaluation of the ROC in the presence of DVB-T interference. The full Monte Carlo approach would consist of simulating the full transmission/reception scheme shown in Figure 5 and generating several realizations of
and
where
and defines the SNR at the correlator outputs.
Schematic representation of the full Monte Carlo simulation system for the ROC evaluation of the acquisition of a GPS L1 signal in the presence of DVB-T third order harmonics.
The correlator output can be considered iid complex Gaussian random variables even in the presence of DVB-T interference. More specifically, the large number of terms in the sum performed in (12) allows one to invoke the central limit theorem and assume
The analytical knowledge of the system can be further exploited to simplify the evaluation of
where
Finally, exploiting the linearity of the correlation process, it is possible to express
which is a linear combination of a useful signal term, derived from
Schematic representation of the semi-analytic approach adopted for the evaluation of the ROC in the presence of DVB-T interference. The three functional elements of the semi-analytic approach are highlighted in different colors.
Using the results derived in [24], [13] and [23], it is possible to show
and
where
The function
The function
The only unknown parameter in the previous equation is the SSC, which needs to be estimated using Monte Carlo simulations. Also, the interfering DVB-T signal is fully simulated. The resulting signal is filtered by the receiver front-end and the sequence
The developed semi-analytic approach is shown in Figure 6 where the simulation, estimation and analytic components are clearly highlighted.
Representation of a normalized PSD realization of the third harmonic of the DVB-T signal and the frequency response of the GPS L1 front-end filter.
A comparison between a full Monte Carlo simulation and a semi-analytic technique, implemented for the evaluation of the acquisition performance of a GPS L1 receiver impaired by third order harmonics of a DVB-T signal, is presented in this section. Initially, the DVB-T interfering signal in time domain is programmed in MT by following the DVB-T standard and the non-linear amplifier model, as illustrated in Figure 5. Note that the simulation of the interfering signal is required for both Monte Carlo and semi-analytic techniques. Subsequently, the estimated PSD of the interfering signal, needed for the estimation of the SSC in the semi-analytic method, is obtained by applying the pwelch function of MT. A realization of the normalized PSD of the interfering signal is depicted in Figure 7. The centre frequency of the interfering signal is set to
Sample results comparing ROC curves obtained using semi-analytic and Monte Carlo simulations are shown in Figure 8. The parameters used for the analysis are reported in Table 2. From Figure 8, it can be observed that the Monte Carlo and semi-analytic approaches provide similar results and the curves obtained using the two methods overlap. However, the semi-analytic approach provides increased precision, particularly when small values need to be estimated, and a significant reduction in terms of computational complexity. Full Monte Carlo simulations require the implementation of the full transmission/reception chain and the evaluation of the ROC with a computational complexity significantly higher than that of the semi-analytic approach described above.
Comparison between ROC curves obtained using semi-analytic and Monte Carlo simulations. The semi-analytic framework considered provides increased precision and requires a lower computational complexity.
Parameter | Value |
CN | |
Coherent integration time, | |
Interference to signal power ratio, | |
Centre frequency difference, | |
Receiver bandwidth, | |
Number of Monte Carlo Simulation runs |
Parameters used for the evaluation of the ROC curves shown in Figure 8.
Additional results relative to the impact of DVB-T interference on GNSS can be found in [25].
As anticipated in Section 1, a second configuration, called
http://www.ngs.noaa.gov/gps-toolbox/SATLSim.htm
http://plan.geomatics.ucalgary.ca/publications.php.
In the following, the closed-loop approach for the simulation of digital tracking loops is considered and the MT code developed in the SATLSim toolbox is briefly analyzed.
A description of the correlator model used for reducing the computational complexity of the system is at first provided. The samples given by (7) at the input of a GNSS receiver are processed by the different functional blocks with different objectives. The acquisition process described in Section 2 is the first stage of a GNSS receiver and has the goal of determining the signal presence and provide a rough estimate of its parameters. These parameters include the code delay
If the signal is successfully acquired then different tracking loops are used to refine the estimate of the signal parameters. A DLL is usually used to provide accurate estimates of the code delay,
As indicated in Section 2, a subcarrier can be used for shaping the spectrum of the transmitted GNSS signal and improving its robustness against multipath. The presence of a subcarrier makes code tracking more complex since the correlation function of the transmitted signal may have multiple peaks. More specifically, fine delay estimation is obtained by maximizing the correlation between input signal and local code: the correlation function is maximized only when the delay of the locally generated code matches the delay of the input signal. The presence of several peaks in the correlation function may cause the DLL to converge to a local maximum causing biases in the delay estimation. For this reason, several solutions have been proposed to avoid lock on secondary correlation peaks [26, 27]. An effective solution is represented by the SLL proposed by [27]. In this case, the subcarrier is seen as a periodic waveform that further modulates the transmitted signal. The delays of code and subcarrier are decoupled and estimated separately. In this way, the ambiguous one-dimensional signal correlation is projected in an unambiguous bi-dimensional function. In the following, the joint simulation of DLL and SLL is considered.
In a GNSS tracking loop, the incoming signal is correlated with several locally generated code and carrier replicas and different correlator outputs are produced. This process is analogous to the correlation operations described in Section 2 and is performed by the ID blocks.
Each correlator output is a function of the input signal and the parameters previously estimated by the tracking loop. The correlator outputs are passed to the non-linear discriminator that produces a first estimate of the tracking error that the loop is trying to minimize. The tracking error is filtered and passed to the NCO that is used for generating new local signal replicas.
Efficient tracking loop simulations can be obtained by substituting the ID blocks with their analytical model. More specifically, a correlator output can be modeled as:
where
From (26), it is possible to reconstruct the correlator outputs given the estimation errors generated by the tracking loops. Thus, the correlation process does not need to be simulated and only the estimation errors are determined using a Monte Carlo approach. Based on this principle, the simulation scheme shown in Figure 9 can be adopted for the fast simulation of digital tracking loops.
Semi-analytic scheme adopted for the simulation of GNSS tracking loops. Each element of the scheme proposed for the analysis of tracking loops has been implemented in a different function of the SATLSim toolbox.
The functional elements in Figure 9 have been grouped to form the simulation block, the analytical model and the estimation part. The analytical model is used to convert the signal parameter errors,
By modifying these functional blocks, it is possible to simulate different tracking loops. In the simulation scheme implemented in the SATLSim toolbox, a new estimate of the tracking parameters (Doppler frequency, carrier phase and code and subcarrier delays) is generated by an NCO model. This model accounts for the integration process performed by a real NCO and different update equations can be used [28]. A commonly used model is the rate-only feedback NCO [28], characterized by the following update equation:
where
The operations required to convert the correlator outputs into a new estimate of the parameter rate,
The structure of the code developed in the SATLSim toolbox is provided in Figure 10. In this case, the code is used to estimate the tracking jitter of the loop as a function of different parameters, such as the Early-minus-Late spacing and the input CN. In particular, the non-linear discriminator may use several correlators to compute the cost function that the loop is trying to minimize. A DLL usually requires at least two correlators, named Early and Late correlators, computed for the delays
where
Structure of the SATLSim toolbox and list of the different MT functions.
The parameters required for initializing the simulation procedure are accessible through the function InitSettings. These parameters include the sampling frequency, the loop bandwidth and the coherent integration time that are used to design the loop filters through the function FilterDesign. In the code provided, standard formulae from [21] are used. However, FilterDesign can be modified in order to adopt a different approach, such as the controlled-root formulation proposed by [28]. During the initialization phase, the true input parameters are also generated. The simulation core consists of three nested loops, on the Early-minus-Late spacing, for different CN values and for the number of simulation runs. The loop on Early-minus-Late spacing can be absent if, for example, only a PLL is considered. For each Early-minus-Late spacing and for a fixed CN, a noise vector containing the noise components of the correlator outputs is generated. The vector length is equal to the number of simulation runs and all the noise components are generated at once for efficiency reasons.
All intermediate results, such as the discriminator and loop filter outputs, are stored in auxiliary vectors and are used at the end of the loop on the simulation runs to evaluate quantities of interest such as the tracking jitter.
In the code provided, theoretical formulae for the computation of the tracking jitter are also implemented and used as a comparison term for the simulation results.
The simulation of a standard PLL requires the generation of the Prompt correlator alone (GenerateSignalCorrelation). The Prompt correlator is the output of the ID block computed with respect to the best delay estimate provided by the loop [21]. For this reason, the noise generation (GenerateNoiseVector) simply consists of simulating a one dimensional complex Gaussian white sequence with independent and identically distributed real and imaginary parts with variance [9]
When simulating a standard PLL alone, perfect code synchronization is assumed and (26) simplifies to
where
In SATLSim, the function UpdateDiscriminator implements a standard Costas discriminator. Different phase discriminators, as indicated in [21], can be easily implemented by changing this function.
In the DE case, i.e. when DLL and SLL are jointly used, the function GenerateNoiseVector, responsible for the generation of the correlator noise, produces a
where
The NCO update (UpdateNCO) is performed on both code and subcarrier loops and the estimated errors,
The DE provides an example of how several tracking loops, operating in parallel, can be easily coupled in order to provide more realistic simulations accounting for the interaction of different tracking algorithms [9].
In this section, sample results obtained using the SATLSim toolbox are shown for the DE case. Results for the analysis of the PLL can be found in [10]. Specific focus is devoted to the analysis of the tracking jitter, which is one of the main metrics used for the analysis of digital tracking loops. The tracking jitter quantifies the amount of noise transferred by the tracking loop to the final parameter estimate [29]. The tracking jitter is the standard deviation of the final parameter estimate normalized by the discriminator gain. The non-linear discriminator is usually a memoryless device characterized by an input/output function relating the parameter estimation error to the discriminator output. The discriminator gain is the slope of this function in the neighborhood of zero (hypothesis of small estimation error).
Tracking jitter results obtained using non-coherent discriminators [21] for both DLL and SLL are shown in Figure 11. The figure is divided into three parts: [a)]
Tracking jitter of the DLL alone
Tracking jitter of the SLL alone
Jitter of the combined delay estimate.
This is due to the fact that the DE jointly uses a DLL, for estimating the code delay, and a SLL, for determining the subcarrier delay. Subcarrier and code delay are then combined to obtain the final estimate of the travel time of the transmitted signal [27]. Thus, three different jitters are evaluated for the different estimates produced by the system. Tracking jitter has been expressed in meters by multiplying the standard deviation of the delay estimates by the speed of light.
Tracking jitter obtained using the SATLSim toolbox. a) Tracking jitter of the DLL alone. b) Tracking jitter of the SLL alone. c) Jitter of the combined delay estimate.
In addition to this, the curves are shown in Figure 11 a) and\n\t\t\t\t\tFigure 11 b). More specifically, three different methodologies have been employed for determining the tracking jitter. The theoretical curve corresponds to approximate formulas obtained by linearizing the input/output function of the non-linear discriminator. These formulas are valid only for small tracking errors or equivalently for high CN. The jitter obtained from the actual error has been obtained by evaluating the variance of the code phase error. It is noted that in a real tracking loop the code phase error is not directly accessible since the true code phase is unknown. Thus, the tracking error can be evaluated by measuring the error at the loop filter output, which is an observable point, and propagating its variance through the loop. The tracking jitter obtained by propagating the variance at this measurable point corresponds to the curve denoted by “Estimated from the loop filter output”. The relationship between the variances of the discriminator output and the true tracking error can easily be evaluated when the loop is working in its linear region. The measured curve was introduced to further validate the theoretical model and test the correctness of the simulation methodology. This latest curve is not available for the combined delay estimate.
The parameters used for the evaluation of the tracking jitter, shown in Figure 11, are provided in Table 3.
Parameter | Value |
Sampling Frequency | |
Integration Time | |
DLL Early-minus-Late spacing | |
SLL Early-minus-Late spacing | |
DLL Loop Order | |
SLL Loop Order | |
DLL Loop Bandwidth | |
SLL Loop Bandwidth | |
Modulation type | BOC(1, 1) |
Parameters used for the evaluation of the tracking jitter shown in Figure 11.
From the results shown in Figure 11, it is observed that the developed semi-analytic technique is able to effectively capture the behavior of the system. For high CN values, a good agreement between theoretical and simulation results is found. However, for CN lower than
In this chapter, the development of fast semi-analytic techniques using MT has been analyzed. In the semi-analytic framework, the knowledge of the system under analysis is exploited to reduce the computational load and complexity that full Monte Carlo simulations would require. In this way, the strengths of both analytical and Monte Carlo methods are effectively combined.
Two examples of semi-analytic techniques have been thoroughly analyzed and used to illustrate the two main configurations developed within the semi-analytic framework. The first example illustrates the sequential configuration where simulations and the analytical model are used sequentially. This type of configuration provides increased precision with respect to full Monte Carlo simulations, particularly when the quantities to be estimated assume small values. In addition to this, a significant reduction in terms of computational complexity is achieved. In the example considered, full Monte Carlo simulations require the implementation of a full transmission/reception chain including the interaction between two different systems, DVB-T and GNSS. This requirement led to a significant computational and development complexity. The considered semi-analytic approach is an effective solution for alleviating those requirements.
The second example considered the closed-loop approach and specific focus was devoted to the SATLSim MT toolbox. This toolbox has been developed for the analysis of digital tracking loops and fully exploits the flexibility of the MT programming language. The code has been organized in functions that can be easily replaced by different MT modules. In this way, different loop components such as discriminators, loop filters and NCO models can be integrated in the SATLSim toolbox. The efficiency of semi-analytic techniques and the reduced development time enabled by the MT language are an effective tool for the analysis of complex communications systems.
Iron deficiency is the most common nutritional deficiency across the world and an important public health problem, particularly in developing countries [1]. Anemia, defined as a low hemoglobin concentration, is a public health problem that affects low-, middle-, and high-income countries, having significant adverse health consequences, as well as adverse impacts not only to the health of citizens, but also to the socio-economic development [2]. The high prevalence of iron deficiency anemia in developing countries most often is attributed to nutritional deficiencies worsened by chronic blood loss due to parasitic infections and malaria. In the industrialized nations, the most common cause of iron deficiency with or without anemia is insufficient dietary iron [3].
Approximately 50% of cases of anemia are considered to be an iron deficiency, but the proportion probably varies among population groups and in different areas, according to the local conditions [2]. Unfortified complementary foods particularly have a low iron content, iron deficiency, also iron deficiency anemia (IDA) are consequently major public health problems in infants and young children, especially in poor populations [4].
Anemia resulting from iron deficiency adversely affects cognitive and motor development, causes fatigue and low productivity [2]. Iron plays a role in various essential physiological functions, such as oxygen transport, gene regulation, DNA synthesis, DNA repair, and brain function [5]. Iron serves important functions in biochemical processes including the development of the central nervous system, and it is essential to neural myelination, neurotransmitter function, neuronal energy metabolism and neurite differentiation [6].
Many studies have shown an association between iron deficiency anemia and poor neurodevelopment in infants that lasts beyond the period of deficiency [6]. This article aims to explain iron metabolism in children, also discuss the role of hematologic and biochemical parameters for screening and diagnosis of iron deficiency anemia (IDA) in children.
Hemoglobin levels at birth are normally quite high and primarily consist of fetal hemoglobin (HbF or α2γ2), which comprises 80–90% of the total hemoglobin synthesized, gradually decreasing to <1% by 10 months of age in normal infants. The switch from hemoglobin F to adult hemoglobin (HbA or α2β2) begins around 12 weeks of gestation, although the production of hemoglobin A occurs in the bone marrow where it remains throughout the life [7].
Iron requirements in late infancy are higher than during any other period in life due to rapid growth. A unique feature of human iron metabolism is the absence of an excretory pathway and regulation of iron absorption is very important for homeostasis [4]. At birth, most of the body iron is found in the blood hemoglobin, but a term, healthy, normal birth weight infant also has some iron stores, appropriate to about 25% of the total body iron [8].
Knowledge of iron metabolism in infants and children has been enhanced due to recent discoveries of protein and peptides regulating iron absorption. Iron is absorbed in the small intestine by divalent metal transporter 1 (DMT1) and is stored by ferritin inside the mucosal cells or taken by ferroportin to the systemic circulation, while being oxidized by hephaestin to be integrated into transferrin. Hepcidin, a small peptide that is synthesized by the liver, can sense iron stores and regulates iron transport by ferroportin inhibition [7].
The majority of iron required by the body is obtained from the reuse of iron released from erythrocyte catabolism. However, sufficient amounts of iron must be supplied by the diet to replace the iron that is lost from the body (through exfoliation of the skin and gastrointestinal cells; and blood loss) and the iron that is needed for growth [9]. At birth, most of the body iron is found in blood hemoglobin, but a term, healthy, normal birth weight infant also has some iron stores, corresponding to about 25% of the total body iron [8].
Healthy, full-term, normal birth weight infants are born with sufficient stores of iron to cover their needs during the first 4–6 months of life [9]. The healthy infant at term is born with iron stores which can be partially mobilized and utilized for growth during early infancy. In addition to these stores, the high levels of hemoglobin at birth will decrease and the iron will be recycled and also used for growth and blood-volume expansion [7].
The huge demand for iron in the late fetal and early postnatal period is for hemoglobin (Hb) synthesis [10]. Some theories are estimating the iron requirements of infants. Total body iron varies with birthweight and has been estimated to be approximately 268 mg for an infant with a birthweight of 3.5 kg and approximately 183 mg for an infant with a birthweight of 2.5 kg [7].
Premature infants are at high risk of iron deficiency (ID) due to inadequate iron storage caused by the factors of preterm birth, early onset of postnatal erythropoiesis, and rapid growth after birth. There is a lack of a gold standard to describe iron status clinically for healthy preterm infants [10].
Iron bioavailability is commonly assumed to be 50% from breast milk and 10% from mixed foods. The stable isotope method can be applied to assess iron absorption in children [4]. Iron homeostasis is mainly controlled through tightly regulated changes in iron absorption in adults. Three “regulators” of iron hemostasis mechanisms have been identified which are referred to as the “erythropoietic regulator”, the “stores regulator”, and the “dietary regulator” [7].
Iron deficiency and overload are protected by the regulation of these compartments which are integrated to control iron absorption. The store’s regulator has a predominant role in maintaining iron homeostasis in response to endogenous iron stores. The dietary regulator may functionally respond to acute changes in iron intake, primarily to prevent iron overload [7].
Iron is absorbed from the diet in primarily the duodenum and jejunum. Iron cannot pass through cellular membrane unassisted. The primary importer of iron across the apical membrane of the intestinal epithelial cell is divalent metal transporter 1 (DMT1, also known as Nramp2, and DCT1). To date, only 1 transmembrane transporter protein, solute carrier family 11, member 2 (Slc11a2, also known as DMT1, is known to have physiological importance in bringing iron into cells. DMT1 is essential for iron absorption, based on a murine study explained that lack the gene encoding DMT1 develop severe IDA. Slc11a2 acts as a proton-dependent iron importer of Fe2+. It can also transport a variety of other divalent metal cations, including Mn2+, Co2+, Cu2+, and Zn2+ [11].
Iron homeostasis is regulated at the level of intestinal absorption. Several proteins must synchronize the transfer of iron across the enterocyte and into the systemic circulation. Iron acquired from the diet, is generally in the ferric (Fe3+) state and must be reduced to the ferrous form (Fe2+) before uptake into the enterocyte, presumably by an apical membrane-associated ferric reductase, possibly duodenal cytochrome
Hepcidin has an important role in the regulation of iron absorption. The hepatic synthesis of this peptide is induced by high serum iron concentrations and circulating hepcidin leads to decreased expression of ferroportin on the basolateral membrane of enterocytes, thereby blocking the dietary iron transport into the blood. On the contrary, hepcidin is downregulated in iron deficiency leading to an increase in intestinal iron absorption. It is not yet known whether hepcidin is involved in the significant developmental changes in iron metabolism that occur during the first year of life [4].
Iron homeostasis is primarily regulated at the level of intestinal absorption in adults; thus, the ontogeny of this homeostatic system has developmental consequences. The study from Lὅnnerdal and Kelleher explained a hypothesis that the increase in iron absorption that occurs during infancy reflects the maturation of the small intestine iron absorption mechanism to facilitate iron transfer into the systemic circulation [7].
Despite the magnitude of the difference in bioavailability of iron from breast milk and infant formula varies among studies, most investigators agree that iron is absorbed better from breast milk. A major part of iron in breast milk is associated with lactoferrin. Human lactoferrin is absorbed across the apical membrane of the intestinal cell via a specific lactoferrin receptor and internalized with its bound iron. Thus, lactoferrin facilitates a unique mechanism for the absorption of iron from breast milk. The molecular reasons for the lack of homeostasis of iron metabolism in young infants are not yet known. Iron absorption is refractory to hepcidin during the neonatal period, despite intact hepcidin signaling during this period. The mechanism for iron absorption and its regulation is different during early life than in adults, so further research is needed in this area [6].
Transferring transports absorbed iron to the liver, where it is taken up into hepatocytes by transferrin receptors and stored sequestered in ferritin until needed. Iron is released from ferritin and mobilized into the hepatic circulation for further distribution to the tissue, during times of high demand. The regulation of this process is just beginning to be explained, and our concept has been aided by the identification of several genes expressed in the liver that when mutated cause hereditary hemochromatosis, resulting in iron overload. These genes contain those for hepcidin, hemochromatosis protein (HFE), transferrin receptor 2 (TfR2), and hemojuvelin [7].
Anemia may be caused by decreased RBC production, increased RBC destruction, or blood loss [12]. In developing countries, iron deficiency (ID) and iron deficiency anemia (IDA) typically result from insufficient dietary intake, loss of blood due to intestinal worm colonization, or both. In high-income countries, certain eating habits (e.g., vegetarian diet) and pathologic conditions (e.g., chronic blood loss or malabsorption) are the most common causes [13].
Inadequate intake together with rapid growth, low birth weight and gastrointestinal loss due to excessive consumption of cow’s milk are the most common causes of IDA in children. Iron crossing through the placenta is the only source of iron during the intrauterine period. In the final period of pregnancy, the total amount of iron in the fetus is 75 mg/kg. If there is no significant cause of blood loss, physiological anemia begins in the postnatal period and iron stores are sufficient to provide erythropoiesis in the first 6 months of life. Stores are exhausted earlier in babies with perinatal blood loss and in low birth weight infants, since they are smaller. Improvement of the iron status and reduction of the risk of iron deficiency can be done by delaying umbilical cord clamping [1].
The iron-fortified formula helps ensure adequate iron supplies for infants. However, toddlers often have diets that contain large amounts of cow milk and minimal amounts of iron-rich foods. The risk of iron deficiency may be increased by the early introduction of whole cow milk (before 1 year of age) and consumption of greater whole cow milk after the first year of life. Cow milk is not only low in iron, it also interferes with iron absorption. Cow milk may cause unknown gastrointestinal bleeding in some infants [14].
Adolescent females may become anemic due to menstrual losses. Some children develop anemia due to Meckel diverticulum, chronic epistaxis, or inflammatory bowel disease, which all cause blood loss. Iron is absorbed from the gastrointestinal tract and transported into the blood bound to transferrin. Excess iron is stored primarily in the liver, bone marrow, and spleen as ferritin [14].
Three main body iron compartments describe iron status inadequacy: iron stores, transport iron, and functional iron. Depletion of each component leads to a different iron deficiency stage. Short-term variations in physiologic iron needs are met by the release of iron stores, the majority of which are available as intracellular ferritin, predominantly in hepatocytes and specialized macrophages [15].
Iron deficiency (ID) can be divided into 4 major categories: 1) iron depletion (a state in which the low level of iron affects nonhematologic pathways (e.g., brain, muscle); where microcytic anemia that is classically seen in iron deficiency anemia (IDA) is not found, 2) iron-restricted erythropoiesis (a condition with some impairment of hematologic function without evidence of anemia or microcytosis), 3) IDA (a clinical picture with reduced hemoglobin levels, in which neurodevelopmental and musculoskeletal functions have been inhibited), 4) Functional iron deficiency (a state in which iron stores are adequate but unavailable for biological use). This typical laboratory findings of each category can be seen in Table 1 [5].
Laboratory finding | Iron depletion | Iron-restricted erythropoiesis | Iron deficiency anemia | Functional iron deficiency |
---|---|---|---|---|
Hemoglobin | Normal | Normal | Reduced | Normal |
MCV | Normal | Normal to reduced | Reduced | Reduced |
Serum iron (SI) | Normal | Reduced | Reduced | Normal |
Serum ferritin | Reduced | Reduced | Reduced | Normal to elevated |
TIBC | Normal | Increased | Increased | Increased |
sTfR | Normal | Increased | Increased | Increased |
CHr or Ret-He | Normal | Decreased | Decreased | Decreased |
Hepcidin | Reduced | Reduced | Reduced | Elevated |
Classification of the iron states and associated laboratory findings.
MCV: mean corpuscular volume; TIBC: total iron-binding capacity; sTfR: soluble transferrin receptor; CHr or Ret-He: reticulocyte hemoglobin content.
Iron deficiency affects a variety of physiological functions [5]. Iron deficiency refers to the reduction of iron stores that precedes overt iron deficiency anemia or persists without progression. Iron deficiency anemia is a more severe condition in which low levels of iron are associated with anemia and the presence of microcytic hypochromic red cells [13].
Serum ferritin represents a small fraction of the body’s ferritin pool, but the concentration of ferritin reflects the amount of iron stores. Once iron stores are depleted, the first stage of iron deficiency (ID) is reached, namely iron depletion, but there are no erythropoietic consequences yet [15].
The iron supply provided by the transport iron compartment is mainly for red blood cell (RBC) production because the demand of iron for erythropoiesis is much larger than other tissues. The second stage of ID, namely iron-deficiency erythropoiesis, occurs without showing a notable decrease in hemoglobin concentration, when the supply can no longer be met. Laboratory parameters providing information about the adequacy of iron supply are transferrin saturation (TSAT) and the concentrations of erythrocyte protoporphyrin (EP), and soluble transferrin receptor (sTfR). The percentage of binding sites on all transferrin molecules occupied with iron molecules is represented by TSAT, and is calculated as the ratio of serum iron to transferrin or serum iron to total iron-binding capacity (TIBC) [15].
Impairment of the delivery of iron to erythroid is indicated by iron-restricted erythropoiesis, no matter how replete the stores. In cases of anemia of chronic inflammation, stores may be normal or even increased because of iron sequestration, which is observed in patients with autoimmune disorders, infections, and chronic kidney diseases [13]. Common indicator considerations require biological confounding caused by the inflammation. Inflammation is a highly complex biological process, confounding the interpretation of iron status indicators, especially serum ferritin concentration because it increases in response to inflammation as well as to increased iron stores [15].
In uncomplicated IDA (without inflammation response), there is a reduction in iron stores, transport iron, and functional iron. Transferrin production is upregulated to increase iron transport, as soon as the iron supply to erythropoiesis becomes insufficient. Upregulation of transferrin receptor production happens to facilitate iron delivery to cells increasing sTfR, and zinc protoporphyrin (ZPP) is produced instead of heme resulting in an increase of erythrocyte protoporphyrin (EP). Serum ferritin and Hb concentration are important indicators in uncomplicated IDA [15].
The functional iron deficiency is a state of iron-poor erythropoiesis in which there is an insufficient mobilization of iron from stores in the presence of increased demands, as is observed after treatment with erythropoiesis-stimulating agents [13].
A detailed history (anamnesis) of the patient and physical examination is crucial in the diagnosis of all diseases in medical science. A study has shown that a detailed history can diagnose anemia with a sensitivity of 71% and specificity of 79% [16]. Particularly, prenatal period, times of starting breastmilk and solid foods, bleeding history and nutrition should be considered in detail, also signs other systemic diseases and anemia that may accompany [1].
A hemoglobin (Hb) value 5 percentile below the normal hemoglobin value specified for that age or reduced erythrocyte count in healthy individuals is defined as anemia. Anemia should be defined by paying attention to the lower limit of the normal value for different age groups and gender [1]. Hemoglobin concentration is the key indicator for a functionally important iron deficit, specifically iron deficiency anemia (IDA). The hematocrit does not reveal any additional information other than hemoglobin [15]. Based on the size of RBC, hematologists categorize the anemia as macrocytic, normocytic, or microcytic [12].
Anemia in children has a broad differential diagnosis, but it narrows once the anemia is classified further as microcytic. The most common causes of this in children are iron deficiency and thalassemia minor. Microcytosis also results from lead poisoning, chronic diseases (e.g., inflammation, infection, etc.), sideroblastic anemia, and other rare conditions [14].
Reduction in MCV and MCH (mean corpuscular hemoglobin) in a CBC result is a manifestation of reduced hemoglobin in erythrocytes. The erythrocytes are paler and smaller than normal on the peripheral blood smear, (microcytic and hypochromic). MCV and MCH are parallel to each other; meaning erythrocytes may be microcytic and hypochromic at the same time. An MCH below 27 pg. is considered low. The normal value of MCV ranges between 80 and 99 fL, but in children, normal values differ according to age. Laboratory findings in iron deficiency are shown in Table 2 below [1]. The data from our study (Table 3) shows significant differences in hematologic parameters between the β-thalassemia minor and IDA groups. The higher RBC increase in the IDA group compared to the β-thalassemia minor (BTMi) group was probably related to the administration of iron therapy in children with IDA [17].
Complete blood count: |
RDW >14 RBC: low Hb, Hct: low according to age and gender MCV: low according to age and gender When specifying the lower limit of MCV: 70 + age (for >10 years) (if MCV is <72, generally abnormal) Upper limit of MCV: 84 + age x 0.6 (for >6 months) (if MCV is >98, always abnormal) MCH <27 pg. MCHC <30% Thrombocytosis Rarely: thrombocytopenia, leukopenia |
Peripheral blood smear: |
Hypochromic Microcytosis Anisochromic Anisocytosis Pencil cells Rarely: basophilic stippling, target cells, hyper segmented neutrophils Serum ferritin <12 ng/mL *Serum iron <30 mcg/dL *TIBC >480 mcg/dL Transferrin saturation (SI/TIBC × 100%) <16% Mentzer index (MCV/RBC) <13 |
Iron deficiency laboratory findings.
May change by age, gender, and other factors. Should be evaluated together.
Parameter | BTMi (n: 159) | IDA (n: 64) | ||
---|---|---|---|---|
Range | Mean ± SD | Range | Mean ± SD | |
Hb (g/dL) | 4.49–14 | 8.53 | 5.07–16.3 | 10.96 |
Hct (%) | 13.6–43.8* | 27.57 | 14.7–51.6* | 34.15 |
RBC (×106/μL) | 1.9–6.77* | 3.86 | 2.06–6.05* | 4.46 |
MCV (fL) | 55.0–99.3 | 71.95 | 63.4–90.7 | 76.48 |
MCH (pg) | 16.6–31.7 | 22.34 | 20.0–28.7 | 24.59 |
MCHC | 26.5-34.9 | 30.96 | 27.6–34.9 | 32.20 |
RDW-CV (%) | 8.3–34* | 20.15 | 10.5–30.9* | 14.6 |
Hematological parameters of the group of β-thalassemia minor (BTMi) and iron deficiency anemia.
Significant,
Note: Hb: hemoglobin; RBC: red blood cell; MCV: mean corpuscular volume; MCH: mean corpuscular hemoglobin; MCHC: mean corpuscular hemoglobin concentration; RDW-CV: red cell distribution width-coefficient of variation.
Differential diagnosis of microcytic hypochromic anemia is very important to consider because the interpretation of its’ peripheral blood can be found in iron deficiency anemia and β-thalassemia trait. Iron deficiency and β-thalassemia minor are best differentiated using serum ferritin level, serum iron level, total iron-binding capacity, transferrin saturation, and Hb A2 level, along with a complete blood count (CBC) and examination of peripheral blood film [18]. Carriers of β-thalassemia are usually clinically asymptomatic. However, they have characteristics of the CBCs with mean corpuscular volume (MCV) less than 80 fL and mean corpuscular hemoglobin (MCH) less than 27 p. [19].
Anemia evaluation can be done by an array of tests, but there is no single “best” test to diagnose iron deficiency, with or without anemia. The “gold standard” for identifying iron deficiency is bone marrow biopsy with Prussian blue staining. Since, bone marrow aspiration is an invasive procedure, indirect assays are used for routine use. The laboratory tests that may be used to support and consider the diagnosis of iron deficiency are complete blood count (CBC), peripheral blood smear, reticulocyte, iron profile (SI, TIBC, and transferrin saturation index), sTfR level, and biochemical tests based on iron metabolism (e.g., zinc protoporphyrin-ZPP, serum ferritin concentration) [14]. In CBC, if anemia is present, it should be primarily checked if hemoglobin and hematocrit values are normal for age and gender. In infants younger than 6 months, lower values are observed because of physiological anemia, but hemoglobin levels are not expected to be lower than 9 g/dL in physiological anemia in term infants if there is no other accompanying factor [1].
Iron has a role in various essential physiological functions, such as oxygen transport, gene regulation, DNA synthesis, DNA repair, and brain function. Depletion of and inability to use iron disturbs these pathways and causes multiple morbidities. Iron deficiency anemia (IDA) is a well-known complication, but iron deficiency alone may cause negative impacts on the health risk of pediatric patients.
The high prevalence of iron deficiency anemia in developing countries most often is attributed to nutritional deficiencies worsened by chronic blood loss due to parasitic infections and malaria. The differential diagnosis for anemia in children is broad, but it narrows once the anemia is classified further as microcytic. Iron deficiency and thalassemia minor are the most common causes of microcytic anemia in children.
An array of tests can be used for evaluating anemia, but there is no single “best” test to diagnose iron deficiency, with or without anemia. The “gold standard” for identifying iron deficiency is bone marrow biopsy with Prussian blue staining. The laboratory tests that may be used to support and consider the diagnosis of iron deficiency are complete blood count (CBC), peripheral blood smear, reticulocyte, iron profile (SI, TIBC, and transferrin saturation index), sTfR level, and biochemical tests are based on iron metabolism.
The authors declare no conflict of interest.
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Almeida, Julianeli Tolentino de Lima, Luciano Augusto de Araújo Ribeiro, Lucindo José Quintans Júnior and José Maria Barbosa Filho",authors:[{id:"68388",title:"Dr.",name:"Xirley",middleName:null,surname:"Nunes",slug:"xirley-nunes",fullName:"Xirley Nunes"},{id:"70159",title:"Dr.",name:"Lucindo",middleName:null,surname:"Quintans-Júnior",slug:"lucindo-quintans-junior",fullName:"Lucindo Quintans-Júnior"},{id:"72113",title:"Prof.",name:"Jackson",middleName:"Roberto Guedes Da Silva",surname:"Almeida",slug:"jackson-almeida",fullName:"Jackson Almeida"},{id:"72114",title:"Dr.",name:"Julianeli",middleName:"Tolentino",surname:"Lima",slug:"julianeli-lima",fullName:"Julianeli Lima"},{id:"73341",title:"Prof.",name:"José Maria",middleName:null,surname:"Barbosa-Filho",slug:"jose-maria-barbosa-filho",fullName:"José Maria Barbosa-Filho"},{id:"76185",title:"Dr.",name:"Luciano",middleName:null,surname:"Ribeiro",slug:"luciano-ribeiro",fullName:"Luciano Ribeiro"},{id:"76187",title:"MSc.",name:"Fabrício",middleName:null,surname:"Silva",slug:"fabricio-silva",fullName:"Fabrício Silva"}]},{id:"32903",doi:"10.5772/30459",title:"Potato Peel as a Source of Important Phytochemical Antioxidant Nutraceuticals and Their Role in Human Health - A Review",slug:"potato-peel-as-a-source-of-important-phytochemical-antioxidant-nutraceuticals-and-their-role-in-huma",totalDownloads:8553,totalCrossrefCites:12,totalDimensionsCites:28,abstract:null,book:{id:"1958",slug:"phytochemicals-as-nutraceuticals-global-approaches-to-their-role-in-nutrition-and-health",title:"Phytochemicals as Nutraceuticals",fullTitle:"Phytochemicals as Nutraceuticals - Global Approaches to Their Role in Nutrition and Health"},signatures:"A. Al-Weshahy and V.A. Rao",authors:[{id:"82663",title:"Dr.",name:"Venketeshwer",middleName:null,surname:"Rao",slug:"venketeshwer-rao",fullName:"Venketeshwer Rao"},{id:"150485",title:"Dr.",name:"Amir",middleName:null,surname:"Al-Weshahy",slug:"amir-al-weshahy",fullName:"Amir Al-Weshahy"}]},{id:"69956",doi:"10.5772/intechopen.88829",title:"Biostimulants and Their Role in Improving Plant Growth under Abiotic Stresses",slug:"biostimulants-and-their-role-in-improving-plant-growth-under-abiotic-stresses",totalDownloads:2666,totalCrossrefCites:9,totalDimensionsCites:25,abstract:"Biostimulants are products that reduce the need for fertilizers and increase plant growth, resistance to water and abiotic stresses. In small concentrations, these substances are efficient, favoring the good performance of the plant’s vital processes, and allowing high yields and good quality products. In addition, biostimulants applied to plants enhance nutrition efficiency, abiotic stress tolerance and/or plant quality traits, regardless of its nutrient contents. Several researches have been developed in order to evaluate the biostimulants in improving plant development subjected to stresses, saline environment, and development of seedlings, among others. Furthermore, various raw materials have been used in biostimulant compositions, such as humic acids, hormones, algae extracts, and plant growth-promoting bacteria. In this sense, this chapter aims to approach the use of biostimulants in plant growth according to the raw material used in their compositions as well as their effects on plants subjected to abiotic stresses.",book:{id:"8954",slug:"biostimulants-in-plant-science",title:"Biostimulants in Plant Science",fullTitle:"Biostimulants in Plant Science"},signatures:"Ana Carolina Feitosa de Vasconcelos and Lúcia Helena Garófalo Chaves",authors:null},{id:"32894",doi:"10.5772/27308",title:"Antimicrobial and Antioxidant Activities of Some Plant Extracts",slug:"antimicrobial-and-antioxidant-activities-of-some-plant-extracts",totalDownloads:7084,totalCrossrefCites:7,totalDimensionsCites:20,abstract:null,book:{id:"1958",slug:"phytochemicals-as-nutraceuticals-global-approaches-to-their-role-in-nutrition-and-health",title:"Phytochemicals as Nutraceuticals",fullTitle:"Phytochemicals as Nutraceuticals - Global Approaches to Their Role in Nutrition and Health"},signatures:"Elita Scio, Renata F. Mendes, Erick V.S. Motta, Paula M.Q. Bellozi, Danielle M.O. Aragão, Josiane Mello, Rodrigo L. Fabri, Jussara R. Moreira, Isabel V.L. de Assis and Maria Lúcia M. Bouzada",authors:[{id:"69660",title:"Dr.",name:"Elita",middleName:null,surname:"Scio",slug:"elita-scio",fullName:"Elita Scio"},{id:"76248",title:"MSc.",name:"Rodrigo",middleName:null,surname:"Fabri",slug:"rodrigo-fabri",fullName:"Rodrigo Fabri"},{id:"76251",title:"MSc.",name:"Danielle",middleName:null,surname:"Aragão",slug:"danielle-aragao",fullName:"Danielle Aragão"},{id:"76253",title:"Ms.",name:"Renata",middleName:null,surname:"Mendes",slug:"renata-mendes",fullName:"Renata Mendes"},{id:"76256",title:"Mr.",name:"Erick",middleName:null,surname:"Motta",slug:"erick-motta",fullName:"Erick Motta"},{id:"76259",title:"Ms.",name:"Isabel",middleName:null,surname:"Assis",slug:"isabel-assis",fullName:"Isabel Assis"},{id:"76261",title:"Ms.",name:"Jussara",middleName:null,surname:"Moreira",slug:"jussara-moreira",fullName:"Jussara Moreira"},{id:"76262",title:"MSc.",name:"Maria Lucia",middleName:null,surname:"Bouzada",slug:"maria-lucia-bouzada",fullName:"Maria Lucia Bouzada"},{id:"76264",title:"Ms.",name:"Paula",middleName:null,surname:"Bellozi",slug:"paula-bellozi",fullName:"Paula Bellozi"},{id:"76266",title:"MSc.",name:"Josiane",middleName:null,surname:"Mello",slug:"josiane-mello",fullName:"Josiane Mello"}]}],mostDownloadedChaptersLast30Days:[{id:"69956",title:"Biostimulants and Their Role in Improving Plant Growth under Abiotic Stresses",slug:"biostimulants-and-their-role-in-improving-plant-growth-under-abiotic-stresses",totalDownloads:2664,totalCrossrefCites:9,totalDimensionsCites:25,abstract:"Biostimulants are products that reduce the need for fertilizers and increase plant growth, resistance to water and abiotic stresses. In small concentrations, these substances are efficient, favoring the good performance of the plant’s vital processes, and allowing high yields and good quality products. In addition, biostimulants applied to plants enhance nutrition efficiency, abiotic stress tolerance and/or plant quality traits, regardless of its nutrient contents. Several researches have been developed in order to evaluate the biostimulants in improving plant development subjected to stresses, saline environment, and development of seedlings, among others. Furthermore, various raw materials have been used in biostimulant compositions, such as humic acids, hormones, algae extracts, and plant growth-promoting bacteria. In this sense, this chapter aims to approach the use of biostimulants in plant growth according to the raw material used in their compositions as well as their effects on plants subjected to abiotic stresses.",book:{id:"8954",slug:"biostimulants-in-plant-science",title:"Biostimulants in Plant Science",fullTitle:"Biostimulants in Plant Science"},signatures:"Ana Carolina Feitosa de Vasconcelos and Lúcia Helena Garófalo Chaves",authors:null},{id:"69577",title:"Role of Fungi in Agriculture",slug:"role-of-fungi-in-agriculture",totalDownloads:1648,totalCrossrefCites:6,totalDimensionsCites:7,abstract:"Fungi are a group of eukaryotic organisms and source of food, organic acids, alcohol, antibiotics, growth-promoting substances, enzymes, and amino acids. They include microorganisms like molds, yeasts, and mushrooms. They live on dead or living plants or animals’ tissue. Fungi are very different from other living organisms; they are the primary decomposers of substances in the ecological system. Fungi are tremendous decomposer of organic waste material and most readily attack cellulose, lignins, gums, and other organic complex substances. Fungi can act also under a wide range of soil reaction from acidic to alkaline soil reactions. Fungi conjointly play a basic role in different physiological processes as well as mineral and water uptake, chemical change, stomatal movement, and biosynthesis of compounds termed biostimulants, auxins, lignan, and ethylene to enhance the flexibility of plants to ascertain and cope environmental stresses like drought, salinity, heat, cold, and significant metals.",book:{id:"8954",slug:"biostimulants-in-plant-science",title:"Biostimulants in Plant Science",fullTitle:"Biostimulants in Plant Science"},signatures:"Muthuraman Yuvaraj and Murugaragavan Ramasamy",authors:[{id:"280193",title:"Dr.",name:"Muthuraman",middleName:null,surname:"Yuvaraj",slug:"muthuraman-yuvaraj",fullName:"Muthuraman Yuvaraj"},{id:"289410",title:"Dr.",name:"Murugaragavan",middleName:null,surname:"Ramasamy",slug:"murugaragavan-ramasamy",fullName:"Murugaragavan Ramasamy"}]},{id:"62653",title:"Phytochemical Composition: Antioxidant Potential and Biological Activities of Corn",slug:"phytochemical-composition-antioxidant-potential-and-biological-activities-of-corn",totalDownloads:2214,totalCrossrefCites:1,totalDimensionsCites:4,abstract:"Corn seeds are used as a nutritional source for humans, and the stem and leaves are utilized as fodder for cattle throughout the world. Corn silk and corn cob are usually discarded as waste. This chapter highlights the nutritional as well as medicinal importance of various parts of corn plant. All parts of corn plant are good source of a variety of bioactive phytochemical compounds which possess antioxidant potential. The principal phytochemicals present in corn seed and corn silk include polyphenols, phenolic acids, flavonoids, anthocyanins, glycosides, carotenoids, and polysaccharides of biological importance, reducing compounds and some water-soluble vitamins. The presence of these phytochemicals makes corn a medicinal plant which shows various biological activities particularly the antioxidant, antimicrobial, antidiabetic, anti-obesity, antiproliferative, hepatoprotective, cardioprotective, and renal-protective activities. On the account of its high antioxidant potential, all parts of corn plant can be used for the management of oxidative stress and the treatment of various diseases.",book:{id:"7206",slug:"corn-production-and-human-health-in-changing-climate",title:"Corn",fullTitle:"Corn - Production and Human Health in Changing Climate"},signatures:"Haq Nawaz, Saima Muzaffar, Momna Aslam and Shakeel Ahmad",authors:[{id:"230900",title:"Mr.",name:"Haq",middleName:null,surname:"Nawaz",slug:"haq-nawaz",fullName:"Haq Nawaz"},{id:"244066",title:"Prof.",name:"Saima",middleName:null,surname:"Muzaffar",slug:"saima-muzaffar",fullName:"Saima Muzaffar"},{id:"263041",title:"Ms.",name:"Momna",middleName:null,surname:"Aslam",slug:"momna-aslam",fullName:"Momna Aslam"},{id:"263042",title:"Dr.",name:"Shakeel",middleName:null,surname:"Ahmad",slug:"shakeel-ahmad",fullName:"Shakeel Ahmad"}]},{id:"70950",title:"Role of Biofertilizers in Plant Growth and Soil Health",slug:"role-of-biofertilizers-in-plant-growth-and-soil-health",totalDownloads:1436,totalCrossrefCites:4,totalDimensionsCites:11,abstract:"Biofertilizers nowadays have been realised for shifting fortunes in agriculture. It has been proven successful technology in many developed countries while in developing countries exploitation of bioinoculants is hampered by several factors. Scientific knowledge on bioinoculants and its usage will pave way for its effective usage. At the same time overlooking the significance of ensuring and maintaining a high quality standard of the product will have negative impact. Hence a proper knowledge of bioinoculants and its functioning will pave way to tape the resources in a better way. Thus the chapter provide overview knowledge about different bacterial, fungal and algal biofertilizers, its associations with plants and transformations of nutrients in soil. Adopting a rational approach to the use and management of microbial fertilizers in sustainable agriculture thrive vast potential for the future.",book:{id:"8004",slug:"nitrogen-fixation",title:"Nitrogen Fixation",fullTitle:"Nitrogen Fixation"},signatures:"Murugaragavan Ramasamy, T. Geetha and M. Yuvaraj",authors:[{id:"289410",title:"Dr.",name:"Murugaragavan",middleName:null,surname:"Ramasamy",slug:"murugaragavan-ramasamy",fullName:"Murugaragavan Ramasamy"}]},{id:"67454",title:"Nitrogen Fertilization I: Impact on Crop, Soil, and Environment",slug:"nitrogen-fertilization-i-impact-on-crop-soil-and-environment",totalDownloads:1620,totalCrossrefCites:7,totalDimensionsCites:17,abstract:"Nitrogen (N) is a major limiting nutrient to sustain crop yields and quality. As a result, N fertilizer is usually applied in large quantity to increase crop production throughout the world. Application of N fertilizers has increased crop yields and resulted in achievement of self-sufficiency in food production in many developing countries. Excessive application of N fertilizers beyond crops’ demand, however, has resulted in undesirable consequences of degradation in soil, water, and air quality. These include soil acidification, N leaching in groundwater, and emissions of nitrous oxide (N2O), a potent greenhouse gas that contributes to global warming. Long-term application of ammonia-based N fertilizers, such as urea, has increased soil acidity which rendered to soil infertility where crops fail to respond with further application of N fertilizers. Another problem is the groundwater contamination of nitrate-N (NO3-N) which can be a health hazard to human and livestock if its concentration goes above 10 mg L−1 in drinking water. The third problem is emissions of N2O gas which is 300 times more powerful than carbon dioxide in terms of global warming potential. This chapter examines the effect of N fertilization on soil and environmental quality and crop yields.",book:{id:"8004",slug:"nitrogen-fixation",title:"Nitrogen Fixation",fullTitle:"Nitrogen Fixation"},signatures:"Upendra M. Sainju, Rajan Ghimire and Gautam P. Pradhan",authors:[{id:"214367",title:"Dr.",name:"Upendra",middleName:null,surname:"Sainju",slug:"upendra-sainju",fullName:"Upendra Sainju"},{id:"266570",title:"Prof.",name:"Rajan",middleName:null,surname:"Ghimire",slug:"rajan-ghimire",fullName:"Rajan Ghimire"},{id:"266571",title:"Prof.",name:"Gautam",middleName:null,surname:"Pradhan",slug:"gautam-pradhan",fullName:"Gautam Pradhan"}]}],onlineFirstChaptersFilter:{topicId:"349",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:11,numberOfPublishedChapters:91,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:108,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:333,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:11,numberOfPublishedChapters:144,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:126,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:23,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:13,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. 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His research interests and specialties include financial econometrics, financial economics, international economics and finance, housing markets, financial markets, among others.",institutionString:null,institution:{name:"University of Southampton",institutionURL:null,country:{name:"United Kingdom"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:3,paginationItems:[{id:"86",title:"Business and Management",coverUrl:"https://cdn.intechopen.com/series_topics/covers/86.jpg",isOpenForSubmission:!0,editor:{id:"128342",title:"Prof.",name:"Vito",middleName:null,surname:"Bobek",slug:"vito-bobek",fullName:"Vito Bobek",profilePictureURL:"https://mts.intechopen.com/storage/users/128342/images/system/128342.jpg",biography:"Dr. Vito Bobek works as an international management professor at the University of Applied Sciences FH Joanneum, Graz, Austria. He has published more than 400 works in his academic career and visited twenty-two universities worldwide as a visiting professor. 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At the Ministry of Justice of Slovenia, she is a member of examination boards for court expert candidates and judicial appraisers in the following areas: economy/finance, valuation of companies, banking, and forensic investigation of economic operations/accounting. At the leading business newspaper Finance in Slovenia (Swedish ownership), she is the editor and head of the area for business, finance, tax-related articles, and educational programs.",institutionString:null,institution:{name:"University of Primorska",institutionURL:null,country:{name:"Slovenia"}}},editorThree:null},{id:"87",title:"Economics",coverUrl:"https://cdn.intechopen.com/series_topics/covers/87.jpg",isOpenForSubmission:!0,editor:{id:"327730",title:"Prof.",name:"Jaime",middleName:null,surname:"Ortiz",slug:"jaime-ortiz",fullName:"Jaime Ortiz",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00002zaOKZQA2/Profile_Picture_1642145584421",biography:"Dr. Jaime Ortiz holds degrees from Chile, the Netherlands, and the United States. He has held tenured faculty, distinguished professorship, and executive leadership appointments in several universities around the world. Dr. Ortiz has previously worked for international organizations and non-government entities in economic and business matters, and he has university-wide globalization engagement in more than thirty-six countries. He has advised, among others, the United Nations Development Program, Inter-American Development Bank, Organization of American States, Pre-investment Organization of Latin America and the Caribbean, Technical Cooperation of the Suisse Government, and the World Bank. Dr. Ortiz is the author, co-author, or editor of books, book chapters, textbooks, research monographs and technical reports, and refereed journal articles. He is listed in Who’s Who in the World, Who’s Who in America, Who’s Who in Finance and Business, Who’s Who in Business Higher Education, Who’s Who in American Education, and Who’s Who Directory of Economists. Dr. Ortiz has been a Fulbright Scholar and an MSI Leadership Fellow with the W.K. Kellogg Foundation. 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My method of translating this into day to day in clinical practice is non-exhaustible and my habit of exchanging knowledge and expertise with others in those fields is the code and secret of success.",institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"313277",title:"Dr.",name:"Bartłomiej",middleName:null,surname:"Płaczek",slug:"bartlomiej-placzek",fullName:"Bartłomiej Płaczek",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/313277/images/system/313277.jpg",biography:"Bartłomiej Płaczek, MSc (2002), Ph.D. (2005), Habilitation (2016), is a professor at the University of Silesia, Institute of Computer Science, Poland, and an expert from the National Centre for Research and Development. His research interests include sensor networks, smart sensors, intelligent systems, and image processing with applications in healthcare and medicine. He is the author or co-author of more than seventy papers in peer-reviewed journals and conferences as well as the co-author of several books. He serves as a reviewer for many scientific journals, international conferences, and research foundations. Since 2010, Dr. Placzek has been a reviewer of grants and projects (including EU projects) in the field of information technologies.",institutionString:"University of Silesia",institution:{name:"University of Silesia",country:{name:"Poland"}}},{id:"35000",title:"Prof.",name:"Ulrich H.P",middleName:"H.P.",surname:"Fischer",slug:"ulrich-h.p-fischer",fullName:"Ulrich H.P Fischer",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/35000/images/3052_n.jpg",biography:"Academic and Professional Background\nUlrich H. P. has Diploma and PhD degrees in Physics from the Free University Berlin, Germany. He has been working on research positions in the Heinrich-Hertz-Institute in Germany. Several international research projects has been performed with European partners from France, Netherlands, Norway and the UK. He is currently Professor of Communications Systems at the Harz University of Applied Sciences, Germany.\n\nPublications and Publishing\nHe has edited one book, a special interest book about ‘Optoelectronic Packaging’ (VDE, Berlin, Germany), and has published over 100 papers and is owner of several international patents for WDM over POF key elements.\n\nKey Research and Consulting Interests\nUlrich’s research activity has always been related to Spectroscopy and Optical Communications Technology. Specific current interests include the validation of complex instruments, and the application of VR technology to the development and testing of measurement systems. He has been reviewer for several publications of the Optical Society of America\\'s including Photonics Technology Letters and Applied Optics.\n\nPersonal Interests\nThese include motor cycling in a very relaxed manner and performing martial arts.",institutionString:null,institution:{name:"Charité",country:{name:"Germany"}}},{id:"341622",title:"Ph.D.",name:"Eduardo",middleName:null,surname:"Rojas Alvarez",slug:"eduardo-rojas-alvarez",fullName:"Eduardo Rojas Alvarez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/341622/images/15892_n.jpg",biography:null,institutionString:null,institution:{name:"University of Cuenca",country:{name:"Ecuador"}}},{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/215610/images/system/215610.jpeg",biography:"Muhammad Sarfraz is a professor in the Department of Information Science, Kuwait University. His research interests include computer graphics, computer vision, image processing, machine learning, pattern recognition, soft computing, data science, intelligent systems, information technology, and information systems. Prof. Sarfraz has been a keynote/invited speaker on various platforms around the globe. He has advised various students for their MSc and Ph.D. theses. He has published more than 400 publications as books, journal articles, and conference papers. He is a member of various professional societies and a chair and member of the International Advisory Committees and Organizing Committees of various international conferences. Prof. Sarfraz is also an editor-in-chief and editor of various international journals.",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"32650",title:"Prof.",name:"Lukas",middleName:"Willem",surname:"Snyman",slug:"lukas-snyman",fullName:"Lukas Snyman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/32650/images/4136_n.jpg",biography:"Lukas Willem Snyman received his basic education at primary and high schools in South Africa, Eastern Cape. He enrolled at today's Nelson Metropolitan University and graduated from this university with a BSc in Physics and Mathematics, B.Sc Honors in Physics, MSc in Semiconductor Physics, and a Ph.D. in Semiconductor Physics in 1987. After his studies, he chose an academic career and devoted his energy to the teaching of physics to first, second, and third-year students. After positions as a lecturer at the University of Port Elizabeth, he accepted a position as Associate Professor at the University of Pretoria, South Africa.\r\n\r\nIn 1992, he motivates the concept of 'television and computer-based education” as means to reach large student numbers with only the best of teaching expertise and publishes an article on the concept in the SA Journal of Higher Education of 1993 (and later in 2003). The University of Pretoria subsequently approved a series of test projects on the concept with outreach to Mamelodi and Eerste Rust in 1993. In 1994, the University established a 'Unit for Telematic Education ' as a support section for multiple faculties at the University of Pretoria. In subsequent years, the concept of 'telematic education” subsequently becomes well established in academic circles in South Africa, grew in popularity, and is adopted by many universities and colleges throughout South Africa as a medium of enhancing education and training, as a method to reaching out to far out communities, and as a means to enhance study from the home environment.\r\n\r\nProfessor Snyman in subsequent years pursued research in semiconductor physics, semiconductor devices, microelectronics, and optoelectronics.\r\n\r\nIn 2000 he joined the TUT as a full professor. Here served for a period as head of the Department of Electronic Engineering. Here he makes contributions to solar energy development, microwave and optoelectronic device development, silicon photonics, as well as contributions to new mobile telecommunication systems and network planning in SA.\r\n\r\nCurrently, he teaches electronics and telecommunications at the TUT to audiences ranging from first-year students to Ph.D. level.\r\n\r\nFor his research in the field of 'Silicon Photonics” since 1990, he has published (as author and co-author) about thirty internationally reviewed articles in scientific journals, contributed to more than forty international conferences, about 25 South African provisional patents (as inventor and co-inventor), 8 PCT international patent applications until now. Of these, two USA patents applications, two European Patents, two Korean patents, and ten SA patents have been granted. A further 4 USA patents, 5 European patents, 3 Korean patents, 3 Chinese patents, and 3 Japanese patents are currently under consideration.\r\n\r\nRecently he has also published an extensive scholarly chapter in an internet open access book on 'Integrating Microphotonic Systems and MOEMS into standard Silicon CMOS Integrated circuitry”.\r\n\r\nFurthermore, Professor Snyman recently steered a new initiative at the TUT by introducing a 'Laboratory for Innovative Electronic Systems ' at the Department of Electrical Engineering. The model of this laboratory or center is to primarily combine outputs as achieved by high-level research with lower-level system development and entrepreneurship in a technical university environment. Students are allocated to projects at different levels with PhDs and Master students allocated to the generation of new knowledge and new technologies, while students at the diploma and Baccalaureus level are allocated to electronic systems development with a direct and a near application for application in industry or the commercial and public sectors in South Africa.\r\n\r\nProfessor Snyman received the WIRSAM Award of 1983 and the WIRSAM Award in 1985 in South Africa for best research papers by a young scientist at two international conferences on electron microscopy in South Africa. He subsequently received the SA Microelectronics Award for the best dissertation emanating from studies executed at a South African university in the field of Physics and Microelectronics in South Africa in 1987. In October of 2011, Professor Snyman received the prestigious Institutional Award for 'Innovator of the Year” for 2010 at the Tshwane University of Technology, South Africa. This award was based on the number of patents recognized and granted by local and international institutions as well as for his contributions concerning innovation at the TUT.",institutionString:null,institution:{name:"University of South Africa",country:{name:"South Africa"}}},{id:"317279",title:"Mr.",name:"Ali",middleName:"Usama",surname:"Syed",slug:"ali-syed",fullName:"Ali Syed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/317279/images/16024_n.png",biography:"A creative, talented, and innovative young professional who is dedicated, well organized, and capable research fellow with two years of experience in graduate-level research, published in engineering journals and book, with related expertise in Bio-robotics, equally passionate about the aesthetics of the mechanical and electronic system, obtained expertise in the use of MS Office, MATLAB, SolidWorks, LabVIEW, Proteus, Fusion 360, having a grasp on python, C++ and assembly language, possess proven ability in acquiring research grants, previous appointments with social and educational societies with experience in administration, current affiliations with IEEE and Web of Science, a confident presenter at conferences and teacher in classrooms, able to explain complex information to audiences of all levels.",institutionString:null,institution:{name:"Air University",country:{name:"Pakistan"}}},{id:"75526",title:"Ph.D.",name:"Zihni Onur",middleName:null,surname:"Uygun",slug:"zihni-onur-uygun",fullName:"Zihni Onur Uygun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/75526/images/12_n.jpg",biography:"My undergraduate education and my Master of Science educations at Ege University and at Çanakkale Onsekiz Mart University have given me a firm foundation in Biochemistry, Analytical Chemistry, Biosensors, Bioelectronics, Physical Chemistry and Medicine. After obtaining my degree as a MSc in analytical chemistry, I started working as a research assistant in Ege University Medical Faculty in 2014. In parallel, I enrolled to the MSc program at the Department of Medical Biochemistry at Ege University to gain deeper knowledge on medical and biochemical sciences as well as clinical chemistry in 2014. In my PhD I deeply researched on biosensors and bioelectronics and finished in 2020. Now I have eleven SCI-Expanded Index published papers, 6 international book chapters, referee assignments for different SCIE journals, one international patent pending, several international awards, projects and bursaries. In parallel to my research assistant position at Ege University Medical Faculty, Department of Medical Biochemistry, in April 2016, I also founded a Start-Up Company (Denosens Biotechnology LTD) by the support of The Scientific and Technological Research Council of Turkey. Currently, I am also working as a CEO in Denosens Biotechnology. The main purposes of the company, which carries out R&D as a research center, are to develop new generation biosensors and sensors for both point-of-care diagnostics; such as glucose, lactate, cholesterol and cancer biomarker detections. My specific experimental and instrumental skills are Biochemistry, Biosensor, Analytical Chemistry, Electrochemistry, Mobile phone based point-of-care diagnostic device, POCTs and Patient interface designs, HPLC, Tandem Mass Spectrometry, Spectrophotometry, ELISA.",institutionString:null,institution:{name:"Ege University",country:{name:"Turkey"}}},{id:"267434",title:"Dr.",name:"Rohit",middleName:null,surname:"Raja",slug:"rohit-raja",fullName:"Rohit Raja",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/267434/images/system/267434.jpg",biography:"Dr. Rohit Raja received Ph.D. in Computer Science and Engineering from Dr. CVRAMAN University in 2016. His main research interest includes Face recognition and Identification, Digital Image Processing, Signal Processing, and Networking. Presently he is working as Associate Professor in IT Department, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur (CG), India. He has authored several Journal and Conference Papers. He has good Academics & Research experience in various areas of CSE and IT. He has filed and successfully published 27 Patents. He has received many time invitations to be a Guest at IEEE Conferences. He has published 100 research papers in various International/National Journals (including IEEE, Springer, etc.) and Proceedings of the reputed International/ National Conferences (including Springer and IEEE). He has been nominated to the board of editors/reviewers of many peer-reviewed and refereed Journals (including IEEE, Springer).",institutionString:"Guru Ghasidas Vishwavidyalaya",institution:{name:"Guru Ghasidas Vishwavidyalaya",country:{name:"India"}}},{id:"246502",title:"Dr.",name:"Jaya T.",middleName:"T",surname:"Varkey",slug:"jaya-t.-varkey",fullName:"Jaya T. Varkey",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246502/images/11160_n.jpg",biography:"Jaya T. Varkey, PhD, graduated with a degree in Chemistry from Cochin University of Science and Technology, Kerala, India. She obtained a PhD in Chemistry from the School of Chemical Sciences, Mahatma Gandhi University, Kerala, India, and completed a post-doctoral fellowship at the University of Minnesota, USA. She is a research guide at Mahatma Gandhi University and Associate Professor in Chemistry, St. Teresa’s College, Kochi, Kerala, India.\nDr. Varkey received a National Young Scientist award from the Indian Science Congress (1995), a UGC Research award (2016–2018), an Indian National Science Academy (INSA) Visiting Scientist award (2018–2019), and a Best Innovative Faculty award from the All India Association for Christian Higher Education (AIACHE) (2019). She Hashas received the Sr. Mary Cecil prize for best research paper three times. She was also awarded a start-up to develop a tea bag water filter. \nDr. Varkey has published two international books and twenty-seven international journal publications. She is an editorial board member for five international journals.",institutionString:"St. Teresa’s College",institution:null},{id:"250668",title:"Dr.",name:"Ali",middleName:null,surname:"Nabipour Chakoli",slug:"ali-nabipour-chakoli",fullName:"Ali Nabipour Chakoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/250668/images/system/250668.jpg",biography:"Academic Qualification:\r\n•\tPhD in Materials Physics and Chemistry, From: Sep. 2006, to: Sep. 2010, School of Materials Science and Engineering, Harbin Institute of Technology, Thesis: Structure and Shape Memory Effect of Functionalized MWCNTs/poly (L-lactide-co-ε-caprolactone) Nanocomposites. Supervisor: Prof. Wei Cai,\r\n•\tM.Sc in Applied Physics, From: 1996, to: 1998, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Determination of Boron in Micro alloy Steels with solid state nuclear track detectors by neutron induced auto radiography, Supervisors: Dr. M. Hosseini Ashrafi and Dr. A. Hosseini.\r\n•\tB.Sc. in Applied Physics, From: 1991, to: 1996, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Design of shielding for Am-Be neutron sources for In Vivo neutron activation analysis, Supervisor: Dr. M. Hosseini Ashrafi.\r\n\r\nResearch Experiences:\r\n1.\tNanomaterials, Carbon Nanotubes, Graphene: Synthesis, Functionalization and Characterization,\r\n2.\tMWCNTs/Polymer Composites: Fabrication and Characterization, \r\n3.\tShape Memory Polymers, Biodegradable Polymers, ORC, Collagen,\r\n4.\tMaterials Analysis and Characterizations: TEM, SEM, XPS, FT-IR, Raman, DSC, DMA, TGA, XRD, GPC, Fluoroscopy, \r\n5.\tInteraction of Radiation with Mater, Nuclear Safety and Security, NDT(RT),\r\n6.\tRadiation Detectors, Calibration (SSDL),\r\n7.\tCompleted IAEA e-learning Courses:\r\nNuclear Security (15 Modules),\r\nNuclear Safety:\r\nTSA 2: Regulatory Protection in Occupational Exposure,\r\nTips & Tricks: Radiation Protection in Radiography,\r\nSafety and Quality in Radiotherapy,\r\nCourse on Sealed Radioactive Sources,\r\nCourse on Fundamentals of Environmental Remediation,\r\nCourse on Planning for Environmental Remediation,\r\nKnowledge Management Orientation Course,\r\nFood Irradiation - Technology, Applications and Good Practices,\r\nEmployment:\r\nFrom 2010 to now: Academic staff, Nuclear Science and Technology Research Institute, Kargar Shomali, Tehran, Iran, P.O. Box: 14395-836.\r\nFrom 1997 to 2006: Expert of Materials Analysis and Characterization. Research Center of Agriculture and Medicine. Rajaeeshahr, Karaj, Iran, P. O. Box: 31585-498.",institutionString:"Atomic Energy Organization of Iran",institution:{name:"Atomic Energy Organization of Iran",country:{name:"Iran"}}},{id:"248279",title:"Dr.",name:"Monika",middleName:"Elzbieta",surname:"Machoy",slug:"monika-machoy",fullName:"Monika Machoy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248279/images/system/248279.jpeg",biography:"Monika Elżbieta Machoy, MD, graduated with distinction from the Faculty of Medicine and Dentistry at the Pomeranian Medical University in 2009, defended her PhD thesis with summa cum laude in 2016 and is currently employed as a researcher at the Department of Orthodontics of the Pomeranian Medical University. She expanded her professional knowledge during a one-year scholarship program at the Ernst Moritz Arndt University in Greifswald, Germany and during a three-year internship at the Technical University in Dresden, Germany. She has been a speaker at numerous orthodontic conferences, among others, American Association of Orthodontics, European Orthodontic Symposium and numerous conferences of the Polish Orthodontic Society. She conducts research focusing on the effect of orthodontic treatment on dental and periodontal tissues and the causes of pain in orthodontic patients.",institutionString:"Pomeranian Medical University",institution:{name:"Pomeranian Medical University",country:{name:"Poland"}}},{id:"252743",title:"Prof.",name:"Aswini",middleName:"Kumar",surname:"Kar",slug:"aswini-kar",fullName:"Aswini Kar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252743/images/10381_n.jpg",biography:"uploaded in cv",institutionString:null,institution:{name:"KIIT University",country:{name:"India"}}},{id:"204256",title:"Dr.",name:"Anil",middleName:"Kumar",surname:"Kumar Sahu",slug:"anil-kumar-sahu",fullName:"Anil Kumar Sahu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204256/images/14201_n.jpg",biography:"I have nearly 11 years of research and teaching experience. I have done my master degree from University Institute of Pharmacy, Pt. Ravi Shankar Shukla University, Raipur, Chhattisgarh India. I have published 16 review and research articles in international and national journals and published 4 chapters in IntechOpen, the world’s leading publisher of Open access books. I have presented many papers at national and international conferences. I have received research award from Indian Drug Manufacturers Association in year 2015. My research interest extends from novel lymphatic drug delivery systems, oral delivery system for herbal bioactive to formulation optimization.",institutionString:null,institution:{name:"Chhattisgarh Swami Vivekanand Technical University",country:{name:"India"}}},{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",biography:"An assistant professor at Department of Biomedical Computer Systems, at Institute of Computer Science, Silesian University in Katowice. Scientific interests: computer analysis and processing of images, biomedical images, databases and programming languages. He is an author and co-author of scientific publications covering analysis and processing of biomedical images and development of database systems.",institutionString:"University of Silesia",institution:{name:"University of Silesia",country:{name:"Poland"}}},{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",biography:"Dr. Hadi Mohammadi is a biomedical engineer with hands-on experience in the design and development of many engineering structures and medical devices through various projects that he has been involved in over the past twenty years. Dr. Mohammadi received his BSc. and MSc. degrees in Mechanical Engineering from Sharif University of Technology, Tehran, Iran, and his PhD. degree in Biomedical Engineering (biomaterials) from the University of Western Ontario. He was a postdoctoral trainee for almost four years at University of Calgary and Harvard Medical School. He is an industry innovator having created the technology to produce lifelike synthetic platforms that can be used for the simulation of almost all cardiovascular reconstructive surgeries. He’s been heavily involved in the design and development of cardiovascular devices and technology for the past 10 years. He is currently an Assistant Professor with the University of British Colombia, Canada.",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",country:{name:"Canada"}}},{id:"254463",title:"Prof.",name:"Haisheng",middleName:null,surname:"Yang",slug:"haisheng-yang",fullName:"Haisheng Yang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/254463/images/system/254463.jpeg",biography:"Haisheng Yang, Ph.D., Professor and Director of the Department of Biomedical Engineering, College of Life Science and Bioengineering, Beijing University of Technology. He received his Ph.D. degree in Mechanics/Biomechanics from Harbin Institute of Technology (jointly with University of California, Berkeley). Afterwards, he worked as a Postdoctoral Research Associate in the Purdue Musculoskeletal Biology and Mechanics Lab at the Department of Basic Medical Sciences, Purdue University, USA. He also conducted research in the Research Centre of Shriners Hospitals for Children-Canada at McGill University, Canada. Dr. Yang has over 10 years research experience in orthopaedic biomechanics and mechanobiology of bone adaptation and regeneration. He earned an award from Beijing Overseas Talents Aggregation program in 2017 and serves as Beijing Distinguished Professor.",institutionString:null,institution:{name:"Beijing University of Technology",country:{name:"China"}}},{id:"89721",title:"Dr.",name:"Mehmet",middleName:"Cuneyt",surname:"Ozmen",slug:"mehmet-ozmen",fullName:"Mehmet Ozmen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/89721/images/7289_n.jpg",biography:null,institutionString:null,institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"265335",title:"Mr.",name:"Stefan",middleName:"Radnev",surname:"Stefanov",slug:"stefan-stefanov",fullName:"Stefan Stefanov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/265335/images/7562_n.jpg",biography:null,institutionString:null,institution:{name:"Medical University Plovdiv",country:{name:"Bulgaria"}}},{id:"242893",title:"Ph.D. Student",name:"Joaquim",middleName:null,surname:"De Moura",slug:"joaquim-de-moura",fullName:"Joaquim De Moura",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/242893/images/7133_n.jpg",biography:"Joaquim de Moura received his degree in Computer Engineering in 2014 from the University of A Coruña (Spain). In 2016, he received his M.Sc degree in Computer Engineering from the same university. He is currently pursuing his Ph.D degree in Computer Science in a collaborative project between ophthalmology centers in Galicia and the University of A Coruña. His research interests include computer vision, machine learning algorithms and analysis and medical imaging processing of various kinds.",institutionString:null,institution:{name:"University of A Coruña",country:{name:"Spain"}}},{id:"294334",title:"B.Sc.",name:"Marc",middleName:null,surname:"Bruggeman",slug:"marc-bruggeman",fullName:"Marc Bruggeman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/294334/images/8242_n.jpg",biography:"Chemical engineer graduate, with a passion for material science and specific interest in polymers - their near infinite applications intrigue me. \n\nI plan to continue my scientific career in the field of polymeric biomaterials as I am fascinated by intelligent, bioactive and biomimetic materials for use in both consumer and medical applications.",institutionString:null,institution:null},{id:"255757",title:"Dr.",name:"Igor",middleName:"Victorovich",surname:"Lakhno",slug:"igor-lakhno",fullName:"Igor Lakhno",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255757/images/system/255757.jpg",biography:"Igor Victorovich Lakhno was born in 1971 in Kharkiv (Ukraine). \nMD – 1994, Kharkiv National Medical Univesity.\nOb&Gyn; – 1997, master courses in Kharkiv Medical Academy of Postgraduate Education.\nPh.D. – 1999, Kharkiv National Medical Univesity.\nDSC – 2019, PL Shupik National Academy of Postgraduate Education \nProfessor – 2021, Department of Obstetrics and Gynecology of VN Karazin Kharkiv National University\nHead of Department – 2021, Department of Perinatology, Obstetrics and gynecology of Kharkiv Medical Academy of Postgraduate Education\nIgor Lakhno has been graduated from international training courses on reproductive medicine and family planning held at Debrecen University (Hungary) in 1997. Since 1998 Lakhno Igor has worked as an associate professor in the department of obstetrics and gynecology of VN Karazin National University and an associate professor of the perinatology, obstetrics, and gynecology department of Kharkiv Medical Academy of Postgraduate Education. Since June 2019 he’s been a professor in the department of obstetrics and gynecology of VN Karazin National University and a professor of the perinatology, obstetrics, and gynecology department. He’s affiliated with Kharkiv Medical Academy of Postgraduate Education as a Head of Department from November 2021. Igor Lakhno has participated in several international projects on fetal non-invasive electrocardiography (with Dr. J. A. Behar (Technion), Prof. D. Hoyer (Jena University), and José Alejandro Díaz Méndez (National Institute of Astrophysics, Optics, and Electronics, Mexico). He’s an author of about 200 printed works and there are 31 of them in Scopus or Web of Science databases. Igor Lakhno is a member of the Editorial Board of Reproductive Health of Woman, Emergency Medicine, and Technology Transfer Innovative Solutions in Medicine (Estonia). He is a medical Editor of “Z turbotoyu pro zhinku”. Igor Lakhno is a reviewer of the Journal of Obstetrics and Gynaecology (Taylor and Francis), British Journal of Obstetrics and Gynecology (Wiley), Informatics in Medicine Unlocked (Elsevier), The Journal of Obstetrics and Gynecology Research (Wiley), Endocrine, Metabolic & Immune Disorders-Drug Targets (Bentham Open), The Open Biomedical Engineering Journal (Bentham Open), etc. He’s defended a dissertation for a DSc degree “Pre-eclampsia: prediction, prevention, and treatment”. Three years ago Igor Lakhno has participated in a training course on innovative technologies in medical education at Lublin Medical University (Poland). Lakhno Igor has participated as a speaker in several international conferences and congresses (International Conference on Biological Oscillations April 10th-14th 2016, Lancaster, UK, The 9th conference of the European Study Group on Cardiovascular Oscillations). His main scientific interests: are obstetrics, women’s health, fetal medicine, and cardiovascular medicine. \nIgor Lakhno is a consultant at Kharkiv municipal perinatal center. He’s graduated from training courses on endoscopy in gynecology. He has 28 years of practical experience in the field.",institutionString:null,institution:null},{id:"244950",title:"Dr.",name:"Salvatore",middleName:null,surname:"Di Lauro",slug:"salvatore-di-lauro",fullName:"Salvatore Di Lauro",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0030O00002bSF1HQAW/ProfilePicture%202021-12-20%2014%3A54%3A14.482",biography:"Name:\n\tSALVATORE DI LAURO\nAddress:\n\tHospital Clínico Universitario Valladolid\nAvda Ramón y Cajal 3\n47005, Valladolid\nSpain\nPhone number: \nFax\nE-mail:\n\t+34 983420000 ext 292\n+34 983420084\nsadilauro@live.it\nDate and place of Birth:\nID Number\nMedical Licence \nLanguages\t09-05-1985. Villaricca (Italy)\n\nY1281863H\n474707061\nItalian (native language)\nSpanish (read, written, spoken)\nEnglish (read, written, spoken)\nPortuguese (read, spoken)\nFrench (read)\n\t\t\nCurrent position (title and company)\tDate (Year)\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. Private practise.\t2017-today\n\n2019-today\n\t\n\t\nEducation (High school, university and postgraduate training > 3 months)\tDate (Year)\nDegree in Medicine and Surgery. University of Neaples 'Federico II”\nResident in Opthalmology. Hospital Clinico Universitario Valladolid\nMaster in Vitreo-Retina. IOBA. University of Valladolid\nFellow of the European Board of Ophthalmology. Paris\nMaster in Research in Ophthalmology. University of Valladolid\t2003-2009\n2012-2016\n2016-2017\n2016\n2012-2013\n\t\nEmployments (company and positions)\tDate (Year)\nResident in Ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl.\nFellow in Vitreo-Retina. IOBA. University of Valladolid\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. \n\t2012-2016\n2016-2017\n2017-today\n\n2019-Today\n\n\n\t\nClinical Research Experience (tasks and role)\tDate (Year)\nAssociated investigator\n\n' FIS PI20/00740: DESARROLLO DE UNA CALCULADORA DE RIESGO DE\nAPARICION DE RETINOPATIA DIABETICA BASADA EN TECNICAS DE IMAGEN MULTIMODAL EN PACIENTES DIABETICOS TIPO 1. Grant by: Ministerio de Ciencia e Innovacion \n\n' (BIO/VA23/14) Estudio clínico multicéntrico y prospectivo para validar dos\nbiomarcadores ubicados en los genes p53 y MDM2 en la predicción de los resultados funcionales de la cirugía del desprendimiento de retina regmatógeno. Grant by: Gerencia Regional de Salud de la Junta de Castilla y León.\n' Estudio multicéntrico, aleatorizado, con enmascaramiento doble, en 2 grupos\nparalelos y de 52 semanas de duración para comparar la eficacia, seguridad e inmunogenicidad de SOK583A1 respecto a Eylea® en pacientes con degeneración macular neovascular asociada a la edad' (CSOK583A12301; N.EUDRA: 2019-004838-41; FASE III). Grant by Hexal AG\n\n' Estudio de fase III, aleatorizado, doble ciego, con grupos paralelos, multicéntrico para comparar la eficacia y la seguridad de QL1205 frente a Lucentis® en pacientes con degeneración macular neovascular asociada a la edad. (EUDRACT: 2018-004486-13). Grant by Qilu Pharmaceutical Co\n\n' Estudio NEUTON: Ensayo clinico en fase IV para evaluar la eficacia de aflibercept en pacientes Naive con Edema MacUlar secundario a Oclusion de Vena CenTral de la Retina (OVCR) en regimen de tratamientO iNdividualizado Treat and Extend (TAE)”, (2014-000975-21). Grant by Fundacion Retinaplus\n\n' Evaluación de la seguridad y bioactividad de anillos de tensión capsular en conejo. Proyecto Procusens. Grant by AJL, S.A.\n\n'Estudio epidemiológico, prospectivo, multicéntrico y abierto\\npara valorar la frecuencia de la conjuntivitis adenovírica diagnosticada mediante el test AdenoPlus®\\nTest en pacientes enfermos de conjuntivitis aguda”\\n. National, multicenter study. Grant by: NICOX.\n\nEuropean multicentric trial: 'Evaluation of clinical outcomes following the use of Systane Hydration in patients with dry eye”. Study Phase 4. Grant by: Alcon Labs'\n\nVLPs Injection and Activation in a Rabbit Model of Uveal Melanoma. Grant by Aura Bioscience\n\nUpdating and characterization of a rabbit model of uveal melanoma. Grant by Aura Bioscience\n\nEnsayo clínico en fase IV para evaluar las variantes genéticas de la vía del VEGF como biomarcadores de eficacia del tratamiento con aflibercept en pacientes con degeneración macular asociada a la edad (DMAE) neovascular. Estudio BIOIMAGE. IMO-AFLI-2013-01\n\nEstudio In-Eye:Ensayo clínico en fase IV, abierto, aleatorizado, de 2 brazos,\nmulticçentrico y de 12 meses de duración, para evaluar la eficacia y seguridad de un régimen de PRN flexible individualizado de 'esperar y extender' versus un régimen PRN según criterios de estabilización mediante evaluaciones mensuales de inyecciones intravítreas de ranibizumab 0,5 mg en pacientes naive con neovascularización coriodea secunaria a la degeneración macular relacionada con la edad. CP: CRFB002AES03T\n\nTREND: Estudio Fase IIIb multicéntrico, randomizado, de 12 meses de\nseguimiento con evaluador de la agudeza visual enmascarado, para evaluar la eficacia y la seguridad de ranibizumab 0.5mg en un régimen de tratar y extender comparado con un régimen mensual, en pacientes con degeneración macular neovascular asociada a la edad. CP: CRFB002A2411 Código Eudra CT:\n2013-002626-23\n\n\n\nPublications\t\n\n2021\n\n\n\n\n2015\n\n\n\n\n2021\n\n\n\n\n\n2021\n\n\n\n\n2015\n\n\n\n\n2015\n\n\n2014\n\n\n\n\n2015-16\n\n\n\n2015\n\n\n2014\n\n\n2014\n\n\n\n\n2014\n\n\n\n\n\n\n\n2014\n\nJose Carlos Pastor; Jimena Rojas; Salvador Pastor-Idoate; Salvatore Di Lauro; Lucia Gonzalez-Buendia; Santiago Delgado-Tirado. Proliferative vitreoretinopathy: A new concept of disease pathogenesis and practical\nconsequences. Progress in Retinal and Eye Research. 51, pp. 125 - 155. 03/2016. DOI: 10.1016/j.preteyeres.2015.07.005\n\n\nLabrador-Velandia S; Alonso-Alonso ML; Di Lauro S; García-Gutierrez MT; Srivastava GK; Pastor JC; Fernandez-Bueno I. Mesenchymal stem cells provide paracrine neuroprotective resources that delay degeneration of co-cultured organotypic neuroretinal cultures.Experimental Eye Research. 185, 17/05/2019. DOI: 10.1016/j.exer.2019.05.011\n\nSalvatore Di Lauro; Maria Teresa Garcia Gutierrez; Ivan Fernandez Bueno. Quantification of pigment epithelium-derived factor (PEDF) in an ex vivo coculture of retinal pigment epithelium cells and neuroretina.\nJournal of Allbiosolution. 2019. ISSN 2605-3535\n\nSonia Labrador Velandia; Salvatore Di Lauro; Alonso-Alonso ML; Tabera Bartolomé S; Srivastava GK; Pastor JC; Fernandez-Bueno I. Biocompatibility of intravitreal injection of human mesenchymal stem cells in immunocompetent rabbits. Graefe's archive for clinical and experimental ophthalmology. 256 - 1, pp. 125 - 134. 01/2018. DOI: 10.1007/s00417-017-3842-3\n\n\nSalvatore Di Lauro, David Rodriguez-Crespo, Manuel J Gayoso, Maria T Garcia-Gutierrez, J Carlos Pastor, Girish K Srivastava, Ivan Fernandez-Bueno. A novel coculture model of porcine central neuroretina explants and retinal pigment epithelium cells. Molecular Vision. 2016 - 22, pp. 243 - 253. 01/2016.\n\nSalvatore Di Lauro. Classifications for Proliferative Vitreoretinopathy ({PVR}): An Analysis of Their Use in Publications over the Last 15 Years. Journal of Ophthalmology. 2016, pp. 1 - 6. 01/2016. DOI: 10.1155/2016/7807596\n\nSalvatore Di Lauro; Rosa Maria Coco; Rosa Maria Sanabria; Enrique Rodriguez de la Rua; Jose Carlos Pastor. Loss of Visual Acuity after Successful Surgery for Macula-On Rhegmatogenous Retinal Detachment in a Prospective Multicentre Study. Journal of Ophthalmology. 2015:821864, 2015. DOI: 10.1155/2015/821864\n\nIvan Fernandez-Bueno; Salvatore Di Lauro; Ivan Alvarez; Jose Carlos Lopez; Maria Teresa Garcia-Gutierrez; Itziar Fernandez; Eva Larra; Jose Carlos Pastor. Safety and Biocompatibility of a New High-Density Polyethylene-Based\nSpherical Integrated Porous Orbital Implant: An Experimental Study in Rabbits. Journal of Ophthalmology. 2015:904096, 2015. DOI: 10.1155/2015/904096\n\nPastor JC; Pastor-Idoate S; Rodríguez-Hernandez I; Rojas J; Fernandez I; Gonzalez-Buendia L; Di Lauro S; Gonzalez-Sarmiento R. Genetics of PVR and RD. Ophthalmologica. 232 - Suppl 1, pp. 28 - 29. 2014\n\nRodriguez-Crespo D; Di Lauro S; Singh AK; Garcia-Gutierrez MT; Garrosa M; Pastor JC; Fernandez-Bueno I; Srivastava GK. Triple-layered mixed co-culture model of RPE cells with neuroretina for evaluating the neuroprotective effects of adipose-MSCs. Cell Tissue Res. 358 - 3, pp. 705 - 716. 2014.\nDOI: 10.1007/s00441-014-1987-5\n\nCarlo De Werra; Salvatore Condurro; Salvatore Tramontano; Mario Perone; Ivana Donzelli; Salvatore Di Lauro; Massimo Di Giuseppe; Rosa Di Micco; Annalisa Pascariello; Antonio Pastore; Giorgio Diamantis; Giuseppe Galloro. Hydatid disease of the liver: thirty years of surgical experience.Chirurgia italiana. 59 - 5, pp. 611 - 636.\n(Italia): 2007. ISSN 0009-4773\n\nChapters in books\n\t\n' Salvador Pastor Idoate; Salvatore Di Lauro; Jose Carlos Pastor Jimeno. PVR: Pathogenesis, Histopathology and Classification. Proliferative Vitreoretinopathy with Small Gauge Vitrectomy. Springer, 2018. ISBN 978-3-319-78445-8\nDOI: 10.1007/978-3-319-78446-5_2. \n\n' Salvatore Di Lauro; Maria Isabel Lopez Galvez. Quistes vítreos en una mujer joven. Problemas diagnósticos en patología retinocoroidea. Sociedad Española de Retina-Vitreo. 2018.\n\n' Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor Jimeno. iOCT in PVR management. OCT Applications in Opthalmology. pp. 1 - 8. INTECH, 2018. DOI: 10.5772/intechopen.78774.\n\n' Rosa Coco Martin; Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor. amponadores, manipuladores y tinciones en la cirugía del traumatismo ocular.Trauma Ocular. Ponencia de la SEO 2018..\n\n' LOPEZ GALVEZ; DI LAURO; CRESPO. OCT angiografia y complicaciones retinianas de la diabetes. PONENCIA SEO 2021, CAPITULO 20. (España): 2021.\n\n' Múltiples desprendimientos neurosensoriales bilaterales en paciente joven. Enfermedades Degenerativas De Retina Y Coroides. SERV 04/2016. \n' González-Buendía L; Di Lauro S; Pastor-Idoate S; Pastor Jimeno JC. Vitreorretinopatía proliferante (VRP) e inflamación: LA INFLAMACIÓN in «INMUNOMODULADORES Y ANTIINFLAMATORIOS: MÁS ALLÁ DE LOS CORTICOIDES. RELACION DE PONENCIAS DE LA SOCIEDAD ESPAÑOLA DE OFTALMOLOGIA. 10/2014.",institutionString:null,institution:null},{id:"243698",title:"Dr.",name:"Xiaogang",middleName:null,surname:"Wang",slug:"xiaogang-wang",fullName:"Xiaogang Wang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243698/images/system/243698.png",biography:"Dr. Xiaogang Wang, a faculty member of Shanxi Eye Hospital specializing in the treatment of cataract and retinal disease and a tutor for postgraduate students of Shanxi Medical University, worked in the COOL Lab as an international visiting scholar under the supervision of Dr. David Huang and Yali Jia from October 2012 through November 2013. Dr. Wang earned an MD from Shanxi Medical University and a Ph.D. from Shanghai Jiao Tong University. 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The following concerns will be addressed in this Cell Physiology subject, which will consider all organ systems (e.g., brain, heart, lung, liver; gut, kidney, eye) and their interactions: (1) Neurodevelopment and Neurodevelopmental Disease (2) Free Radicals (3) Tumor Metastasis (4) Antioxidants (5) Essential Fatty Acids (6) Melatonin and (7) Lipid Peroxidation Products and Aging Physiology.
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Angel Catalá belongto the Editorial Board of Journal of lipids, International Review of Biophysical ChemistryFrontiers in Membrane Physiology and Biophysics, World Journal oExperimental Medicine and Biochemistry Research International, W orld Journal oBiological Chemistry, Oxidative Medicine and Cellular Longevity, Diabetes and thePancreas, International Journal of Chronic Diseases & Therapy, International Journal oNutrition, Co-Editor of The Open Biology Journal.",institutionString:null,institution:{name:"National University of La Plata",institutionURL:null,country:{name:"Argentina"}}},editorTwo:null,editorThree:null,series:{id:"10",title:"Physiology",doi:"10.5772/intechopen.72796",issn:"2631-8261"},editorialBoard:[{id:"186048",title:"Prof.",name:"Ines",middleName:null,surname:"Drenjančević",slug:"ines-drenjancevic",fullName:"Ines Drenjančević",profilePictureURL:"https://mts.intechopen.com/storage/users/186048/images/5818_n.jpg",institutionString:null,institution:{name:"University of Osijek",institutionURL:null,country:{name:"Croatia"}}},{id:"187859",title:"Prof.",name:"Kusal",middleName:"K.",surname:"Das",slug:"kusal-das",fullName:"Kusal Das",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSBDeQAO/Profile_Picture_1623411145568",institutionString:"BLDE (Deemed to be University), India",institution:null},{id:"79615",title:"Dr.",name:"Robson",middleName:null,surname:"Faria",slug:"robson-faria",fullName:"Robson Faria",profilePictureURL:"https://mts.intechopen.com/storage/users/79615/images/system/79615.png",institutionString:null,institution:{name:"Oswaldo Cruz Foundation",institutionURL:null,country:{name:"Brazil"}}},{id:"84459",title:"Prof.",name:"Valerie",middleName:null,surname:"Chappe",slug:"valerie-chappe",fullName:"Valerie Chappe",profilePictureURL:"https://mts.intechopen.com/storage/users/84459/images/system/84459.jpg",institutionString:null,institution:{name:"Dalhousie University",institutionURL:null,country:{name:"Canada"}}}]},onlineFirstChapters:{paginationCount:0,paginationItems:[]},publishedBooks:{paginationCount:1,paginationItems:[{type:"book",id:"7726",title:"Swarm Intelligence",subtitle:"Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/7726.jpg",slug:"swarm-intelligence-recent-advances-new-perspectives-and-applications",publishedDate:"December 4th 2019",editedByType:"Edited by",bookSignature:"Javier Del Ser, Esther Villar and Eneko Osaba",hash:"e7ea7e74ce7a7a8e5359629e07c68d31",volumeInSeries:2,fullTitle:"Swarm Intelligence - 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Because of the close relationship between structure and function, studies in human physiology and anatomy seek to understand the mechanisms that help the human body function. The series on human physiology deals with the various mechanisms of interaction between the various organs, nerves, and cells in the human body.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/12.jpg",keywords:"Anatomy, Cells, Organs, Systems, Homeostasis, Functions"},{id:"13",title:"Plant Physiology",scope:"Plant Physiology explores fundamental processes in plants, and it includes subtopics such as plant nutrition, plant hormone, photosynthesis, respiration, and plant stress. In recent years, emerging technologies such as multi-omics, high-throughput technologies, and genome editing tools could assist plant physiologists in unraveling molecular mechanisms in specific critical pathways. The global picture of physiological processes in plants needs to be investigated continually to increase our knowledge, and the resulting technologies will benefit sustainable agriculture.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/13.jpg",keywords:"Plant Nutrition, Plant Hormone, Photosynthesis, Respiration, Plant Stress, Multi-omics, High-throughput Technology, Genome Editing"}],annualVolumeBook:{},thematicCollection:[],selectedSeries:null,selectedSubseries:null},seriesLanding:{item:{id:"6",title:"Infectious Diseases",doi:"10.5772/intechopen.71852",issn:"2631-6188",scope:"This series will provide a comprehensive overview of recent research trends in various Infectious Diseases (as per the most recent Baltimore classification). Topics will include general overviews of infections, immunopathology, diagnosis, treatment, epidemiology, etiology, and current clinical recommendations for managing infectious diseases. Ongoing issues, recent advances, and future diagnostic approaches and therapeutic strategies will also be discussed. This book series will focus on various aspects and properties of infectious diseases whose deep understanding is essential for safeguarding the human race from losing resources and economies due to pathogens.",coverUrl:"https://cdn.intechopen.com/series/covers/6.jpg",latestPublicationDate:"August 18th, 2022",hasOnlineFirst:!0,numberOfOpenTopics:4,numberOfPublishedChapters:126,numberOfPublishedBooks:13,editor:{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",fullName:"Alfonso J. Rodriguez-Morales",profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",biography:"Dr. Rodriguez-Morales is an expert in tropical and emerging diseases, particularly zoonotic and vector-borne diseases (especially arboviral diseases). He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},subseries:[{id:"3",title:"Bacterial Infectious Diseases",keywords:"Antibiotics, Biofilm, Antibiotic Resistance, Host-microbiota Relationship, Treatment, Diagnostic Tools",scope:"