Complex mechanisms from retina to different visual areas allow us to read these lines. The visual system is inevitable for the way we interact with our surroundings as majority of our impressions, memories, feelings are bound to the visual perception. Millions of cortical neurons are implicated and programmed specifically to frame this incredible interface (perception) for us to interact with the world. Neurons in the visual cortex respond essentially to the variations in luminance occurring within their receptive fields, where each neuron fires maximally by acting as a filter for stimulus features such as orientation, motion, direction and velocity, with an appropriate combination of these properties [1-5].
The seminal work of Hubel and Wiesel on the visual cortex of cat [1, 2, 6-8], has been instrumental in establishing the anatomical and physiological aspects of the visual cortex. Many studies by various investigators on the visual cortex of different animals, thereafter, have been phenomenal in understanding the brain in general and the vision in particular; yet, neuronal mechanisms involved in processing of stimuli still elude our complete understanding of cortical functioning. These findings have been crucial in unravelling the organization of the visual cortex. The visual cortex reorganises itself in the postnatal development, within a specific period called ‘the critical period’ , which is a period characterised with pronounced brain plasticity. In recent years, the focus of the research has been to comprehend the ‘reorganization’ of neuronal framework, especially after the so called ‘critical period’ [10-12] in response to various conditions and its ability to adapt accordingly. This amazing tendency of brain to change its neuronal connections and properties is termed ‘plasticity’ . Two common approaches to study the reorganization of visual cortex are frequently applied: deprivation and induced adaptation. Deprivation refers to the removal of sensory inputs, whereas induced adaptation refers to the forceful application of a sensory input. Consequently, neurons communicate dynamically with each other in a specific way self-assembling, auto-calibrating, memorizing and adapting to different stimuli properties, thus responding accordingly to several experiences [14-16].
The aim of this chapter is to primarily focus on how the linkage between cells changes following plastic modifications of cortical neuronal properties, that is, how the reorganization of the cortical network is modulated following adaptation-induced plasticity, as it is inferred by cross-correlating the action potentials of the neurons in the primary visual cortex. We begin with the general architecture of visual cortex (particularly cat visual cortex), followed by a brief introduction to plasticity and adaptation. Then, we cite an example of modification of the neuronal connections before and after adaptation as revealed by cross-correlation method. Based on this example, we propose a model for changing functional connections prior and post adaptation and conclude with how neurons change their functional relationships when forcefully adapted to a non-optimal stimulus.
2. Visual system: Organization
Visual area constitutes about 25 % of the cortex in humans with approximately 5 billion neurons. The study of the visual cortex has revealed many of these visual regions such as V1, V2, V3, V4 and MT on the basis of their anatomical architecture, topography and physiological properties [17, 18]. These regions are involved in processing of multitude of informations (shape, orientation, color, movement, size etc) resulting from the visual pathways, thus making up an image applied to retina.
The cortical area of higher mammals such as cats, monkeys and humans is generally divided into modules of selectivity (e.g. the visual cortex is divided into areas of selectivity called orientation columns). Several characteristics of the visual system of mammals appear to be common to many species [19, 20], though the neurons are distributed in a salt and pepper fashion in the visual cortex of lower animals such as rats and mice, lacking the orientation domains [21, 22]. Research on animal models is used on a large scale to study and investigate the structure and function of the visual system. Monkeys, cats, and mice are commonly used in neurophysiological experiments for understanding cortical mechanisms in general and visual pathways in particular .
2.2. From retina to visual areas
Visual perception begins in the retina where the received light is transformed into electrical signal by a biochemical cascade produced in the rods and cones. The retinal ganglion cells relay the message to the lateral geniculate body (LGN) which consists of six layers . Each layer receives information from the retinal hemi-field of one eye. The axon terminals of ganglion cells which project on each layer form a precise retinotopic map. This retinotopy denotes the spatial organization of neuronal responses to visual stimuli. Indeed, in many parts of the brain, neurons that respond to stimulation from a given portion of the visual field are located right next to the neurons whose receptive fields cover adjacent portions. Therefore, all the neurons in these brain regions form a topographical map of the visual field from its projection onto the retina.
From the LGN, axons are organized into thalamocortical fibres forming the optic radiations. These optic radiations project onto the cortex in specialized visual areas. The distribution of fibres in the cortex can reproduce the visual field on the cortical layer, and the stimulation of a small cortical area leads to the appearance of bright spots called ‘phosphenes’  in a specific location of the visual field. Visual areas begin in the occipital lobe, and the primary visual cortex or area 17 is the main entrance to cortex for thalamic relay cells . The primary visual cortex is organized into functional modules. Neurons with similar receptive fields are organized into columns [26, 27]. Visual neurons have other fundamental properties, such as the direction selectivity of cells in the layer IVβ, and the selectivity for speed [3, 6]. There is another system of alternating columns, which corresponds to the separation of afferents from both eyes. These are the ocular dominance columns. The ocular dominance columns represent bands of cortical tissue alternately occupied by afferents from the left eye or right eye [28-30]. These bands are particularly pronounced at the cortical layer IV, which receives the afferent endings of the lateral geniculate nucleus. Thus the visual cortex is organized into functional maps of orientation, spatial frequency, ocular dominance, temporal frequency which are interrelated to each other [31-33].
Many findings have led to the discovery of thirty different cortical areas that contribute to visual perception. The primary areas (V1) and secondary areas (V2) are surrounded by many other tertiary or associative visual areas such as V3, V4, V5 (or MT) involved in processing various attributes of trigger features [18, 34]. Areas V3 and V3A are selective to the form of stimuli , and neurons of area V4 are selective to colors . Area V5 or MT (middle temporal) is an area where majority of cells are sensitive to motion and direction, and none of which are selective to color .
Moreover, the parallel organization of visual system is involved in the establishment of two major visual pathways: Ventral and dorsal pathways which are indispensable for the object recognition [38, 39]. Figure 1 illustrates the parallel organization of visual system, two major pathways: Green part corresponds to the ventral pathway in the cortex ending in the temporal lobe [38, 40]. It is involved in the processing of information on the characteristics of the objects (shapes, colours, materials), that is, object recognition including faces. Orange part corresponds to the dorsal pathway in the cortex ending in the parietal lobe [38, 40]. This path is associated with spatial vision (action / location) of objects, and is involved in processing of action in space.
3. Neuron types in primary visual cortex
3.1. Pyramidal cells and interneurons
The grey matter in the primary visual cortex is divided into six layers namely I, II, III, IV, V, VI (Figure 2) which comprise of different types of neurons [41, 42]. Two types of neurons are mainly observed: pyramidal cells and interneurons which can be physiologically separated and are the focus of interest in this chapter, that is, how they modify their properties and change linkage with each other post-adaptation. Pyramidal cells are excitatory neurons projecting onto other brain regions [43, 44] whereas stellate cells which are the recipient cells from the relay cells of the LGN correspond to the local excitatory interneurons . In addition, there are interneurons that are inhibitory in nature . Figure 2 illustrates the layers and cell types in primary visual cortex. Each layer has specific cell types and connectivity in primary visual cortex. Layer IV contains many stellate cells, small neurons with dendrites arranged radially around the cell body. Pyramidal cells are found in layers II-III, V and VI and are the only type of neurons that send axons outside the cortex. These neurons exhibit two levels of their dendritic extension: basal level close to the cell body and relatively long apical dendritic branches extending sometimes over the entire thickness of the cortex.
Classically, spike waveforms allow cells’ distinction into two functional cell-groups, that is, excitatory pyramidal cells and inhibitory interneurons [11, 46, 47]. Figure 3 illustrates a typical example of cells distinguished based on their waveforms: fast spike and regular spike. Figure 3a corresponds to a fast spike with steeper ascending slope of the action potential and represents the putative interneuron , whereas Figure 3b corresponds to a regular spike which exhibits a slower ascending slope and represents the putative pyramidal cell .
3.2. Receptive fields
Visual information from the LGN cells firstly projects onto the stellate interneurons in layer IV, which have concentric receptive fields similar to those of LGN neurons [24, 48]. Neurons of layer IV project vertically onto other cortical layers. In layers II / III, cortical cells exhibit a radical transformation of the receptive field organization, where cells respond preferentially to stimuli with properties such as a bar or an edge that has specific characteristics namely orientation, direction, length, width, and motion [3, 6, 49].
Cells in these layers are classified into simple, complex and hypercomplex cells based on their dark or light-edge properties . Simple cell is a cell which has an ON-OFF sub field, that is, it responds to ON or OFF stimuli in the receptive field and has adjacent excitatory and inhibitory areas . Complex neurons have receptive fields larger than those of simple neurons. They are also selective for orientation, but the precise position of the stimulus within the receptive field is less critical because they have no defined ON or OFF sub-areas. That is why a movement of the stimulus through the receptive field is a potent stimulus for some complex neurons [6, 50, 51]. A complex cell does not have adjacent excitatory and inhibitory areas in the receptive field and responds to whole of the receptive field regardless of the exactitude of the stimulus area, though complex cells can be direction-specific . A hypercomplex cell appears to result, when the axons of complex neurons with different orientations converge on it. A hypercomplex cell is selective to lines of a defined length, and if the stimulus exceeds this length the response is diminished due to inhibitory extremities in addition to antagonistic flanks .
Neurons in primary visual cortex are connected laterally and vertically to each other. Lateral or horizontal connections are specified as long range connections between neurons preferring similar stimulus features [52, 53] which are functionally connected to each other at large distance [54, 55]. Vertical connections are specified as inputs to layers II and III from layer IV of the visual cortex [56, 57] which receives its inputs from LGN . From layers II and III, the connections descend to layers V and VI .
Cats have a high performance visual system close to that of primates, making it a very coveted subject for researches to reveal the functional aspects of this complex system [59, 60]. Approaches to study the visual system are based on functional electrophysiology, where animals are anaesthetized and paralyzed for electrophysiological recordings by lowering microelectrodes into regions of interest within the visual area and visually stimulating the neurons [6, 11, 49, 61].
4. Plasticity and adaptation in the visual cortex
Neurons in the mammalian visual cortex are tuned to respond to visual stimuli such as contour orientation, motion, direction, and speed [3, 6, 59]. Preference for orientation in orientation columns is considered relatively stable in the primary visual cortex (V1) as an emergent property that is established early in the life, following the so-called critical period .
Studies from various laboratories have shown that in a fully mature brain, neuronal network restructures itself beyond the postnatal critical period that follows birth [11, 49, 61-65]. Recent investigations revealed the ability of visual neurons to respond to different stimuli conditions (deprivation or imposition) by changing their optimal properties acquired after birth. This adaptation of neurons for visual perception suggests the existence of neuronal plasticity in adults, hence a mature brain.
Adaptation-induced-plasticity of orientation in primary visual cortex is characterized by authors as the ability of cortical neurons to change their preferred orientation following a long [11, 61, 63] or short [62, 65] exposure to a non-preferred orientation for the primary visual cortex neurons in cats, e.g. Long adaptation leads to the shift of orientation tuning towards attractive direction . In a similar fashion, repetitive adaptation to a non-preferred spatial frequency reveals the spatial frequency tuning shifts in cat visual cortex . In general, imposing a particular stimulus induces instructive process to modify neuronal properties, for example, when in the visual cortex of awake mice a single orientation grating stimulus is repeatedly presented; it leads to augmentation of responses evoked exclusively by testing stimulus, that is, the experience led to enhancement of response . In experiments where animals are anaesthetized (e.g. a cat in the experiment described later on) the shifts of peaks of tuning curves following adaptation (described in figure 4) are not attributed to attention modulations. Consequently, these shifts result from basic neuronal processes outside the frame of attentional processes that might impact response magnitudes.
Adaptation studies in recent years have presented a more complex picture where prolonged exposure to a non-preferred orientation has shown modifications in neurons’ preferred orientations. After adaptation to a non preferred orientation, obtained tuning curve for the new preferred orientation (after adaptation) can shift in two directions relative to the original preferred orientation: attractive or repulsive [11, 61, 63, 64]. An attractive shift is a shift of the tuning curve towards the adapting orientation. On the other hand; a repulsive shift is a shift of the tuning curve in the opposite side of the adapting orientation. Figure 4 illustrates types of shifts post-adaptation. Figure 4a corresponds to an attractive shift, in which blue tuning curve represents control optimal orientation (before adaptation), and red tuning curve represents new optimal orientation (after adaptation).The tuning curve shifted towards the adapting orientation. Figure 4b corresponds to the repulsive shift, in which blue tuning curve represents control optimal orientation (before adaptation), and red tuning curve represents new optimal orientation (after adaptation). The tuning curve shifted away from the adapting orientation. Red arrows depict adapting orientation (non-preferred orientation in control).
Attractive shifts are more frequent than repulsive shifts in longer adaptation durations (≥ 6 min) [11, 61]. Repeated or prolonged exposure to an adapter diminished neuronal responses evoked by the original optimal properties, furthermore in parallel, if it is the neuron’s preferred stimulus . Optical imaging investigations in recent years have also revealed the impact of adaptation-induced-plasticity, showing that orientation maps in V1 can be modified by imposing one particular orientation [62, 65, 67].
5. Crosscorrelograms and neuronal relationships in visual cortex
As reviewed above [11, 49, 61-65], adaptation- induced studies on visual cortex can reveal a great deal about the functioning of the visual cortex. Crosscorrelogram analysis is an efficient tool to establish the functional connectivity between neurons. Ever since the crosscorrelogram approach was introduced , it has proved to be an invaluable tool to determine how specific neurons interact with each other. A crosscorrelogram is a histogram used to infer the connectivity between two neurons, where one neuron is reference and other target. The histogram shows us when the spikes of target neuron are related in time to the spikes of reference neuron. The technique has been instrumental in revealing widespread incidences of neuronal synchrony and neuronal time-relationships among various cortical areas [64, 70-78]. For instance, as revealed by crosscorrelogram analysis, synchrony has been reported to be strong between cells with similar preferred parameters due in part to specific connections between cortical domains having similar tuning properties. Thus, based on the crosscorrelogram analysis, the functional network connections can be established between the neurons [58, 71, 79-81].
A typical crosscorrelogram between two neurons to interpret the relation between them is obtained by keeping one of the neurons as reference and calculating the spikes of the other neuron with reference to it. An investigator generally is interested in one of the following patterns as illustrated in figure 5, while he is interpreting crosscorrelograms. Figure 5 illustrates the time relations between two neurons as revealed by shifted and corrected crosscorrelograms when one neuron is reference and other target. A shifted crosscorrelogram is a histogram obtained, when the spikes of the reference cell are shifted by one or two cycles of stimulation. This eliminates the possibility of stimulus-induced-relationship between two neurons. After this the shifted crosscorrelogram is subtracted (corrected) to remove the stimulus-locked -component. Figure 5a corresponds to target cell projecting onto the reference cell. Target neuron fires few milliseconds before the reference cell since the peak of the crosscorrelogram appears few milliseconds before zero, that is, offset from zero, within 5ms. This means there is an excitation from target to the reference cell [79, 81]. Figure 5b corresponds to the reference cell projecting onto the target cell. Target neuron fires few milliseconds after the reference cell since the peak of the crosscorrelogram appears few milliseconds after zero, within 5ms. This means the excitation is from reference cell to the target cell [79, 81]. Figure 5c corresponds to the synchrony between two neurons, as the peak straddles zero [73, 82]. This means there is a common excitatory input to both neurons most likely from other neuron or neurons. Though, various time windows have been taken into consideration ranging from 3ms to 10 ms [72, 79] to reveal the functional connections between the involved neurons, but a time window within 5ms is most frequently used.
Figure 6 corresponds to differential effects of adaptation on synchrony for responses evoked by original orientation and adapting orientation. Figure 6a represents respective spike-waveforms for cell 1 and cell 2. Figure 6b shows crosscorrelograms between cell 1 and cell 2 before adaptation (control). The centered peak corresponds to synchrony. Fig 6c represents crosscorrelograms between cell 1 and cell 2 after adaptation. Synchrony disappeared for original optimal orientation while it persists for responses evoked by adapter. Figure 6d shows respective Peri-Stimulus Time Histograms (PSTH’s) for cells in control (before adaptation). Figure 6e corresponds to respective Peri-Stimulus Time Histograms (PSTH’s) for cells after adaptation. The downward black arrows indicate onset of the drifting sine-wave patch positioned in the receptive field.
Since adaptation modifies the optimal properties of neurons, whether orientation, direction or spatial frequency, it seems reasonable to postulate that these modifications following adaptation induce a rapid reorganization of the inter-neuronal relationships, as revealed by crosscorrelogram analyses. For instance, a recipient neuron programmed since birth to be connected to a specific neuron that responds optimally to one specific property, all of a sudden starts responding optimally to another stimulus, and begins participating in a different network with other neuron- as if breaking its allegiance to the neuron it is programmed to be connected since birth.
6. Network formation
Neurons do not respond in isolation to the trigger features, but in coordination with surrounding neurons. Thus, they encode stimuli features by forming cell assemblies, where in the involved neurons are time related with each other. Recent investigations have revealed the ability of visual neurons to respond to different stimuli conditions by changing their optimal properties acquired after birth. Most of these studies have been done by visual deprivation [9, 83-86], whereas only a few have centered on induced adaptation [11, 62, 64, 87]. This adaptation of neurons to non-optimal stimuli suggests the adaptability of neuronal code to visual stimuli.
Neuronal connections in the cortex generally occur locally [79, 88]. Visual cortex is a highly specialized functional area where the neurons coordinate locally to encode the visual scenes [89, 90, 91]. To reveal how this local circuitry of different neurons in visual cortex is set up and modulated in response to different visual stimuli is of prime importance to understand the mechanisms of information processing. Crosscorrelogram strategy discussed above can be effectively applied to form a neuronal network in response to visual stimuli. Thus, it can be an efficient tool in deciphering the changes in the neuronal code post-adaptation, hence, the mechanisms of plastic modifications can be revealed.
For example, in the Figure 7 we show the network of connections prior and post adaptation between three neurons recorded simultaneously from the same electrode lowered into the primary visual cortex of an anaesthetized cat. In this experiment, a stimulating sine-wave drifting grating was set to excite cells optimally. Shifted and corrected crosscorrlegrams between all the involved neurons were obtained. A time window of 5 ms before or after the zero in the shifted and corrected crosscorrelogram is taken into account for the projection to be valid. The physiological connectivity (synaptic connections, common input) between cells occurs on very small time scales, less than 3 ms [79, 81]. Since we consider a time window of 10 ms in crosscorrelograms for establishing connections, therefore, this connectivity only reflects that the cells function (irrespective of physical connectivity) in coordination with each other in a time-window of 10 ms following a presented stimulus. Figure 7a illustrates the functional connections between three neurons as revealed by their respective crosscorrelograms (shifted and corrected). White projections correspond to established connections before adaptation. Figure 7b illustrates the new functional connections between same neurons as revealed by their respective crosscorrelograms (shifted and corrected). Yellow projection corresponds to the new connection established after adaptation. Dotted gray projection represents the disappeared projection. PC corresponds to the probability coefficient of the connections. Solid green pyramid represents a pyramidal cell and the solid red sphere represents an interneuron. Red curve line indicates 95% significance level.
This changing of connections indicates that the functional relationships between neurons are modified depending on the stimulus features. For instance, following the forceful presentation of a particular stimulus (in this example a different orientation) results in disappearance of some relationships, and appearance of new relationships.
Based on the above example, we hypothesize and propose a model how the network of neurons is modulated prior and post adaptation as revealed by the functional time-relationship of neurons between them. Figure 8 depicts the functional connections between the same neurons before and after adaptation. White projections in figure 8a show the projections that cells have onto each other before adaptation, whereas figure 8b depicts how the network changes in the same group of neurons after adaptation. Some of the connections between the cells remain distinct (white projections) whereas some connections disappear (dotted gray arrows) with appearing new connections (yellow projections).
This chapter reviewed the changes in the cellular properties post-adaptation. Indeed, the optimal trigger features may change following the prolonged application of a stimulus to which the cell responded feebly before adaptation. This phenomenon has been virtually observed in all mammals which have been tested so far. Also in parallel, following adaptation the inter-neuronal relationships are modified. This suggests that the entire cortical network reorganises itself post adaptation, that is, a new cortex is formed, as if designed for changed properties.
To sum it up, it is of prime importance to understand the plastic modifications of brain for various fundamental and medical reasons. This chapter underlined the importance of imposed adaptation studies within brain, particularly in primary visual cortex based on the crosscorrelogram analysis, framing a premise to better understand the functional connectivity [79, 92] and mechanisms in local neuronal circuits between various identified neurons, at least between the pyramidal cells and interneurons before and after adaptation. and post adaptation, thus, could help us to decipher the mechanisms of information processing, hence the neuronal codes governing them.
Hubel DH, Wiesel TN 1959 Receptive Fields of Single Neurones in the Cat’s Striate Cortex. J Physiol. 148 574 591.
Hubel DH, Wiesel TN 1968 Receptive Fields and Functional Architecture of Monkey Striate Cortex. J Physiol. 195 215 243.
Movshon JA 1975 The Velocity Tuning of Single Units in Cat Striate Cortex.J Physiol. 249 445 468.
Martinez L. M. Wang Q. Reid R. C. Pillai C. Alonso J. M. Sommer F. T. Hirsch J. A. 2005 Receptive Field Structure Varies with Layer in the Primary Visual Cortex.Nat Neurosci. 8 372 379.
Bishop PO, Henry GH 1972 Striate Neurons: Receptive Field Concepts.Invest Ophthalmol. 11 346 354.
Hubel DH, Wiesel TN 1962 Receptive Fields, Binocular Interaction and Functional Architecture in the Cat’s Visual Cortex. J Physiol. 160 106 154.
Hubel DH, Wiesel TN 1963a Shape and Arrangement of Columns in Cat’s Striate Cortex. J Physiol. 165 559 568.
Hubel DH, Wiesel TN 1963b Receptive Fields of Cells in Striate Cortex of Very Young, Visually Inexperienced Kittens.J Neurophysiol. 26 994 1002.
Tanaka S. Tani T. Ribot J. O’Hashi K. Imamura 2009, Imamura K (2009) A Postnatal Critical Period for Orientation Plasticity in the Cat Visual Cortex.. 4: e5380 EOF.
Chiu C. Weliki 20032003 The role of neural activity in the development of orientation selectivity. The visual neurosciences. 117 125Cambridge, MA: MIT Press. pp.
Bachatene L. Bharmauria V. Rouat J. Molotchnikoff 2012(2012) Adaptation-induced Plasticity and Spike Waveforms in Cat Visual Cortex. . 23 88 92.
Southwell D. G. Froemke R. C. Alvarez-Buylla A. Stryker M. P. Gandhi S. P. 2010 Cortical Plasticity Induced by Inhibitory Neuron Transplantation. . 327 1145 1148.
Buonomano DV, Merzenich MM 1998 Cortical Plasticity: From Synapses to Maps.Annu Rev Neurosci. 21 149 186.
Laughlin SB, Sejnowski TJ 2003 Communication in Neuronal Networks. . 301 1870 1874.
Singer 2011(2011) Dynamic Formation of Functional Networks by Synchronization. . 69 191 193.
Buzsáki 2010(2010) Neural Syntax: Cell Assemblies, Synapsembles, and Readers. . 68 362 385.
Kujovic M, Zilles K, Malikovic A, Schleicher A, Mohlberg H, Rottschy C, Eickhoff SB, Amunts K (2012) Cytoarchitectonic Mapping of the Human Dorsal Extrastriate Cortex. Brain Struct Funct. [Epub ahead of print]
Felleman DJ, Van Essen DC 1991 Distributed Hierarchical Processing in the Primate. Cereb Cortex. 1 1 47.
Kaschube M. Schnabel M. Löwel S. Coppola D. M. White L. E. Wolf 2010(2010) Universality in the Evolution of Orientation Columns in the Visual Cortex. . 330 1113 1116.
Tyler CJ, Dunlop SA, Lund RD, Harman AM, Dann JF, Beazley LD, Lund JS 1998 Anatomical Comparison of the Macaque and Marsupial Visual Cortex: Common Features That May Reflect Retention of Essential Cortical Elements.J Comp Neurol. 400 449 468.
Ohki K. Chung S. Ch’ng Y. H. Kara P. Reid R. C. 2005 Functional Imaging with Cellular Resolution Reveals Precise Micro-architecture in Visual Cortex.. 433 597 603.
Van Hooser SD 2007Similarity and Diversity in Visual Cortex: Is There a Unifying Theory of Cortical Computation? Neuroscientist. 13 639 656.
Casagrande VA, 2004u X (2004) Parallel visual pathways: a comparative perspective. The Visual Neurosciences. 494 506Cambridge, MA: MIT Press.
Gilbert CD, Wiesel TN 1979 Morphology and Intracortical Projections of Functionally Characterised Neurones in the Cat Visual Cortex.. 280 120 125.
Davis F. A. Bergen D. Schauf C. Mc Donald I. Deutsch 1976(1976) Movement Phosphenes in Optic Neuritis: A New Clinical Sign.. 26 1100 1104.
Hubel DH, Wiesel TN, Stryker MP 1977 Orientation Columns in Macaque Monkey Visual Cortex Demonstrated by the 2-Deoxyglucose Autoradiographic Technique.. 269 328 330.
Blasdel 1986G, Salama G (1986) Voltage-sensitive Dyes Reveal a Modular Organization in Monkey Striate Cortex.. 321 579 585.
Adams DL, Sincich LC, Horton JC 2007 Complete Pattern of Ocular Dominance Columns in Human Primary Visual Cortex.J Neurosci. 27 10391 10403.
Horton JC, Hocking DR 1996 Intrinsic Variability of Ocular Dominance Column Periodicity in Normal Macaque Monkeys.J Neurosci. 16 7228 7239.
Shatz CJ, Stryker MP 1978 Ocular Dominance in Layer IV of the Cat’s Visual Cortex and the Effects of Monocular Deprivation.J Physiol. 281 267 283.
Carandini M. Sengpiel 2004(2004) Contrast Invariance of Functional Maps in Cat Primary Visual Cortex.J Vis. 4 130 143.
Issa N. P. Trepel C. Stryker M. P. 2000 Spatial Frequency Maps in Cat Visual Cortex.J Neurosci. 20 8504 8514.
Issa N. P. Rosenberg A. Husson T. R. 2008 Models and Measurements of Functional Maps in 1J Neurophysiol. 99: 2745 EOF 2754 EOF.
, DeYoe EA, Olavarria J, Knierim J (1990) 1990 Modular and Hierarchical Organization of Extrastriate Visual Cortex in the Macaque Monkey.Cold Spring Harb Symp Quant Biol. 55 679 696.
Essen DC, Zeki SM 1978 The Topographic Organization of Rhesus Monkey Prestriate Cortex.J Physiol. 277 193 226.
, Gadotti A, Cowey A (1992) 1992 Cortical AreaJ Neurosci. 12: 4and its Role in the Perception of Color. 4056 EOF 65 EOF.
Born RT, Bradley DC 2005 Structure and Function of Visual Area MT.Annu Rev Neurosci. 28 157 189.
Mishkin M. Ungerleider L. Macko 1983(1983) Object Vision and Spatial Vision: Two Cortical Pathways.Trends in Neuroscience. 6 414 417.
Di Carlo J. J. Zoccolan D. Rust N. C. 2012How Does the Brain Solve Visual Object Recognition? Neuron. 73 415 434.
(1995). Milner D. A. Goodale M. (1995 The visual brain in action. Oxford University Press
Lin CS, Friedlander MJ, Sherman SM 1979 Morphology of Physiologically Identified Neurons in the Visual Cortex of the Cat.Brain Res. 172 344 348.
Peters 1984(1984) Identified neurons in visual cortex.Trends in Neurosci. 7 375 378
González-Burgos G. Krimer L. S. Povysheva N. V. Barrionuevo G. Lewis D. A. 2005 Functional Properties of Fast Spiking Interneurons and their Synaptic Connections with Pyramidal Cells in Primate Dorsolateral Prefrontal Cortex.J Neurophysiol. 93 942 953.
Povysheva N. V. Gonzalez-Burgos G. Zaitsev A. V. Kröner S. Barrionuevo G. Lewis D. A. Krimer L. S. 2006 Properties of Excitatory Synaptic Responses in Fast-spiking Interneurons and Pyramidal Cells From Monkey and Rat Prefrontal Cortex. Cereb Cortex. 16 541 552.
Markram H. Toledo-Rodriguez M. Wang Y. Gupta A. Silberberg G. Wu 2004(2004) Interneurons of the Neocortical Inhibitory System. Nat Rev Neurosci. 5 793 807.
MJ Ison Mormann. F. Cerf M. Koch C. Fried I. Quiroga R. Q. 2011 Selectivity of Pyramidal Cells and Interneurons in the Human Medial Temporal Lobe. J Neurophysiol. 106 1713 1721.
Wilson FA, O’Scalaidhe SP, Goldman-Rakic PS 1994 Functional Synergism Between Putative Gamma-Aminobutyrate-Containing Neurons and Pyramidal Neurons in Prefrontal Cortex.Proc Natl Acad Sci U S A. 91 4009 4013.
Gilbert CD 1977 Laminar Differences in Receptive Field Properties of Cells in Cat Primary Visual Cortex. J Physiol. 268 391 421.
Marshansky S. Shumikhina S. Molotchnikoff 2011, Shumikhina S, Molotchnikoff S (2011) Repetitive Adaptation Induces Plasticity of Spatial Frequency Tuning in Cat Primary Visual Cortex. . 172 355 365.
Wilson JR, Sherman SM 1976 Receptive-field Characteristics of Neurons in Cat Striate Cortex: Changes with Visual Field Eccentricity.J Neurophysiol. 39 512 533.
JD Pettigrew Nikara. T. Bishop P. O. 1968 Responses to Moving Slits by Single Units in Cat Striate Cortex.Exp Brain Res. 6 373 390.
Das A. Gilbert C. D. 1995 Long-range Horizontal Connections and Their Role in Cortical Reorganization Revealed by Optical Recording of Cat Primary Visual Cortex.. 375 780 784.
Sompolinsky H. Golomb D. Kleinfeld 1990, Kleinfeld D (1990) Global Processing of Visual Stimuli in a Neural Network of Coupled Oscillators.Proc Natl Acad Sci U S A. 87 7200 7204.
Ts’o DY, Gilbert CD, Wiesel TN 1986 Relationships Between Horizontal Interactions and Functional Architecture in Cat Striate Cortex as Revealed by Cross-correlation Analysis.J Neurosci. 6 1160 1170.
Hata Y, Tsumoto T, Sato H, Tamura H (1991) Horizontal Interactions between Visual Cortical Neurones Studied by Cross-correlation Analysis in the Cat. J Physiol. 441: 593-614.
Yoshimura Y, Sato H, Imamura K, Watanabe Y (2000) Properties of Horizontal and Vertical Inputs to Pyramidal Cells in the Superficial Layers of the Cat Visual Cortex. J Neurosci. 20: 1931-1940.
Stratford K. J. Tarczy-Hornoch K. Martin K. A. Bannister N. J. Jack J. J. 1996 Excitatory Synaptic Inputs to Spiny Stellate Cells in Cat Visual Cortex.. 382 258 261.
Alonso JM, Usrey WM, Reid RC 1996 Precisely Correlated Firing in Cells of the Lateral Geniculate Nucleus.. 383 815 819.
De Weerd P. Vandenbussche E. De Bruyn B. Orban G. A. 1990 Illusory Contour Orientation Discrimination in the Cat.Behav Brain Res. 39 1 17.
Bravo M. Blake R. Morrison 1988(1988) Cats See Subjective Contours.Vision Res. 28 861 865.
Ghisovan N. Nemri A. Shumikhina S. Molotchnikoff 2009humikhina S, Molotchnikoff S (2009) Long Adaptation Reveals Mostly Attractive Shifts of Orientation Tuning in Cat Primary Visual Cortex. . 164 1274 1283.
Dragoi V. Sharma J. Sur 2000(2000) Adaptation-induced Plasticity of Orientation Tuning in Adult Visual Cortex.. 28 287 298.
Nemri A. Ghisovan N. Shumikhina S. Molotchnikoff 2009humikhina S, Molotchnikoff S (2009) Adaptive Behavior of Neighboring Neurons During Adaptation-induced Plasticity of Orientation Tuning in VI.BMC Neurosci. 10: 147 EOF.
Ghisovan N. Nemri A. Shumikhina S. Molotchnikoff 2008humikhina S, Molotchnikoff S (2008) Visual Cells Remember Earlier Applied Target: Plasticity of Orientation Selectivity.. 3: e3689 EOF.
Dragoi V. Rivadulla C. Sur 2001(2001) Foci of Orientation Plasticity in Visual Cortex.. 411 80 86.
Frenkel M. Y. Sawtell N. B. Diogo A. C. Yoon B. Neve R. L. Bear M. F. 2006 Instructive Effect of Visual Experience in Mouse Visual Cortex. . 51 339 349.
Voussoughi A. Shumikhina S. Milleret C. Molotchnikoff 2010humikhina S, Milleret C, Molotchnikoff S (2010) Adaptation Modifies the Organization of Orientation Maps in Adult Cat Visual Cortex. II. Pinwhell Reorganization. Soc. Neurosci:371.22
Perkel DH, Gerstein GL, Moore GP 1967 Neuronal Spike Trains and Stochastic Point Processes. I. The Single Spike Train. Biophys J. 7 391 418.
König P. Engel A. K. 1995 Correlated Firing in Sensory-Motor Systems.Curr Opin Neurobiol. 5 511 519.
Singer W. Engel A. K. Kreiter A. K. Munk M. H. Neuenschwander S. Roelfsema P. R. 1997Neuronal Assemblies: Necessity, Signature and Detectability. Trends Cogn Sci. 1 252 261.
Alloway KD, Roy SA 2002 Conditional Cross-correlation Analysis of Thalamocortical Neurotransmission.Behav Brain Res. 135 191 196.
Singer W. Gray C. M. 1995 Visual Feature Integration and the Temporal Correlation Hypothesis.Annu Rev Neurosci. 18 555 586.
Shumikhina S, Guay J, Duret F, Molotchnikoff S (2004) Contextual Modulation of Synchronization to Random Dots in the Cat Visual Cortex. Exp Brain Res. 158: 223-232.
König P. Engel A. K. Singer 1996(1996) Integrator or Coincidence Detector? The Role of the Cortical Neuron Revisited.Trends Neurosci. 19 130 137.
Softky WR, Koch 1993(1993) The Highly Irregular Firing of Cortical Cells is Inconsistent with Temporal Integration of Random EPSPs.J Neurosci. 13 334 350.
Abeles M. 1982 Local cortical circuits: an electrophysiological study. 67 69Berlin:Springer-Verlag.
Takahashi N. Kitamura K. Matsuo N. Mayford M. Kano M. Matsuki N. Ikegaya 2012(2012) Locally Synchronized Synaptic Inputs. Science. 335 353 356.
Duret F. Shumikhina S. Molotchnikoff 2006humikhina S, Molotchnikoff S (2006) Neuron Participation in a Synchrony-encoding Assembly.BMC Neurosci. 7: 72 EOF.
Barthó P. Hirase H. Monconduit L. Zugaro M. Harris K. D. Buzsáki 2004(2004) Characterization of Neocortical Principal Cells and Interneurons by Network Interactions and Extracellular Features.J Neurophysiol. 92 600 608.
Yoshimura Y. Callaway E. M. 2005 Fine-scale Specificity of Cortical Networks Depends on Inhibitory Cell Type and Connectivity.Nat Neurosci. 8 1552 1559.
Csicsvari J. Hirase H. Czurko A. Buzsáki 1998(1998) Reliability and State Dependence of Pyramidal Cell-interneuron Synapses in the Hippocampus: An Ensemble Approach in the Behaving Rat.. 21 179 189.
Ghisovan N. Nemri A. Shumikhina S. Molotchnikoff 2008humikhina S, Molotchnikoff S (2008) Synchrony between Orientation-selective Neurons is Modulated During Adaptation-induced Plasticity in Cat Visual Cortex.BMC Neurosci. 9: 60 EOF.
He H. Y. Hodos W. Quinlan E. M. 2006 Visual Deprivation Reactivates Rapid Ocular Dominance Plasticity in Adult Visual Cortex.J Neurosci. 26 2951 2955.
Daw NW, Fox K, Sato H, Czepita D (1992) Critical Period for Monocular Deprivation in the Cat Visual Cortex. J Neurophysiol. 67: 197-202
Yaka R. Yinon U. Wollberg 1999(1999) Auditory Activation of Cortical Visual Areas in Cats After Early Visual Deprivation.Eur J Neurosci. 11 1301 1312.
Mower GD, Christen WG 1985 Role of Visual Experience in Activating Critical Period in Cat Visual Cortex.J Neurophysiol. 53 572 589.
Gutnisky DA, Dragoi 2008Adaptive Coding of Visual Information in Neural Populations.Nature. 452: 220-4.
Angulo M. C. Staiger J. F. Rossier J. Audinat 2003(2003) Distinct Local Circuits Between Neocortical Pyramidal Cells and Fast-spiking Interneurons in Young Adult Rats.J Neurophysiol. 89 943 953.
Lee WC, Reid RC 2011 Specificity and Randomness: Structure-function Relationships in Neural Circuits. Curr Opin Neurobiol. 21 801 807.
BM Kampa Roth. MM Göbel W. Helmchen 2011(2011) Representation of Visual Scenes by Local Neuronal Populations in Layer 2/3 of Mouse Visual Cortex. Front Neural Circuits. 5: 18.
Wallace DJ, Kerr JN 2010 Chasing the Cell Assembly. Curr Opin Neurobiol. 20 296 305.
Holmgren C. Harkany T. Svennenfors B. Zilberter 2003(2003) Pyramidal Cell Communication Within Local Networks in Layer 2/3 of Rat Neocortex.J Physiol. 551 139 153.