Capitalization associated to the symbols in the composition of the BSE indices
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Barely three months into the new year and we are happy to announce a monumental milestone reached - 150 million downloads.
\n\nThis achievement solidifies IntechOpen’s place as a pioneer in Open Access publishing and the home to some of the most relevant scientific research available through Open Access.
\n\nWe are so proud to have worked with so many bright minds throughout the years who have helped us spread knowledge through the power of Open Access and we look forward to continuing to support some of the greatest thinkers of our day.
\n\nThank you for making IntechOpen your place of learning, sharing, and discovery, and here’s to 150 million more!
\n\n\n\n\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"6717",leadTitle:null,fullTitle:"Oral Microbiology in Periodontitis",title:"Oral Microbiology in Periodontitis",subtitle:null,reviewType:"peer-reviewed",abstract:"This book will serve as a brief yet exhaustive guide to the role of oral microbes in health and disease. It will be useful to dental and medical students and to microbiologists.",isbn:"978-1-78923-475-6",printIsbn:"978-1-78923-474-9",pdfIsbn:"978-1-83881-669-8",doi:"10.5772/intechopen.72261",price:119,priceEur:129,priceUsd:155,slug:"oral-microbiology-in-periodontitis",numberOfPages:102,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"746619365268c3b5cf92bafea23a6bfa",bookSignature:"Sonia Bhonchal Bhardwaj",publishedDate:"August 1st 2018",coverURL:"https://cdn.intechopen.com/books/images_new/6717.jpg",numberOfDownloads:7723,numberOfWosCitations:4,numberOfCrossrefCitations:7,numberOfCrossrefCitationsByBook:1,numberOfDimensionsCitations:11,numberOfDimensionsCitationsByBook:1,hasAltmetrics:0,numberOfTotalCitations:22,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"November 14th 2017",dateEndSecondStepPublish:"December 5th 2017",dateEndThirdStepPublish:"February 3rd 2018",dateEndFourthStepPublish:"April 24th 2018",dateEndFifthStepPublish:"June 23rd 2018",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"178566",title:"Dr.",name:"Sonia Bhonchal",middleName:null,surname:"Bhardwaj",slug:"sonia-bhonchal-bhardwaj",fullName:"Sonia Bhonchal Bhardwaj",profilePictureURL:"https://mts.intechopen.com/storage/users/178566/images/system/178566.jpeg",biography:"Dr. Sonia Bhonchal Bhardwaj, Ph.D., is a senior assistant professor at the Department of Microbiology, Dr. Harvansh Singh Judge Institute of Dental Sciences and Hospital, Panjab University, Chandigarh, India. She has published several international publications in reputed journals as well as books, book chapters, and congress proceedings.\nDr. Bhardwaj has received grants from the Department of Science and Technology (India) and has worked on biofilm formation in Enterococcus faecalis in periodontitis, Streptococcus mutans, and phage therapy. She is a member of the Indian Association of Medical Microbiology (IAMM), Gastrointestinal Infection Society of India (GISI), Association of Microbiologists of India (AMI), and Society for Bacteriophage Therapy (SBRT).",institutionString:"Panjab University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"4",totalChapterViews:"0",totalEditedBooks:"2",institution:{name:"Panjab University",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"1000",title:"Periodontology",slug:"periodontology"}],chapters:[{id:"62319",title:"Introductory Chapter: Oral Flora and Oral Diseases",doi:"10.5772/intechopen.79363",slug:"introductory-chapter-oral-flora-and-oral-diseases",totalDownloads:854,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Sonia Bhonchal Bhardwaj",downloadPdfUrl:"/chapter/pdf-download/62319",previewPdfUrl:"/chapter/pdf-preview/62319",authors:[{id:"178566",title:"Dr.",name:"Sonia Bhonchal",surname:"Bhardwaj",slug:"sonia-bhonchal-bhardwaj",fullName:"Sonia Bhonchal Bhardwaj"}],corrections:null},{id:"60570",title:"Influence of the Oral Microbiome on General Health",doi:"10.5772/intechopen.76213",slug:"influence-of-the-oral-microbiome-on-general-health",totalDownloads:965,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The prevalence of edentulism is common worldwide. While improvements in access to healthcare and dental care are reducing the prevalence rate of edentulism, the rapidly growing number of elderly as a percent of the global population will sustain a need for denture therapy for the foreseeable future. While denture use has positive impacts on the quality of life, their use is associated with some problems and risks. Denture stomatitis, a chronic infection-related inflammatory disorder of the oral mucosa, is extremely common and has been reported to occur in up to two-thirds of denture wearers. Importantly, epidemiology studies have shown edentulism and denture wearing, while not proven as causative factors, to be associated with significant increases in risk for serious systemic diseases, such as chronic obstructive pulmonary disease (COPD), cardiovascular diseases, diabetes, and arthritic disorders. A common linkage across these diseases is an association between increased risk for the disease and chronic inflammation. The nature of surface properties and porosity of denture materials contributes to the attachment of microorganisms and the establishment and growth of the adherent biofilm. Hence, proper denture cleansing is critical in maintaining oral hygiene and general health and perhaps to reduce the risk factors for systemic disease.",signatures:"Zvi G. Loewy, Shoshana Galbut, Ephraim Loewy and David A. Felton",downloadPdfUrl:"/chapter/pdf-download/60570",previewPdfUrl:"/chapter/pdf-preview/60570",authors:[null],corrections:null},{id:"60779",title:"Anaerobic Bacteria Associated with Periodontitis",doi:"10.5772/intechopen.76352",slug:"anaerobic-bacteria-associated-with-periodontitis",totalDownloads:1700,totalCrossrefCites:1,totalDimensionsCites:4,hasAltmetrics:0,abstract:"Oral bacteria are highly associated with oral diseases, and periodontitis is a strongly prevalent disease, presenting a substantial economical burden. Furthermore, there is a strong association between periodontal bacteria and other diseases, such as cardiovascular disease, rheumatoid arthritis, or diabetes, so it becomes clear that efficient periodontal cure would be of good medical benefit to general health. Periodontally, Healthy loci show a low number of bacteria which are cultivable by individual sulcus, 102–103 microorganisms with almost Gram-positive microbiota, including Streptococcus and Actinomyces species. In gingivitis, it is characterized by an increased bacterial number, 104–105 microorganisms by periodontal sulcus, besides an increased diffusion of Gram negative bacteria (15–50%).The increased number of oral bacteria could be associated with the decreased role of the innate and adaptive immunity; so, this chapter will focus on the most prevalent bacteria associated with the oral disease on the one hand and the role of innate immunity and adaptive immunity (Interleukin 1 Beta Il-1β and Tumor necrosis factor-alpha TNF-α) in oral diseases on the other hand.",signatures:"Ahmed Zuhair Jasim Alwaeli",downloadPdfUrl:"/chapter/pdf-download/60779",previewPdfUrl:"/chapter/pdf-preview/60779",authors:[null],corrections:null},{id:"61071",title:"Oral Microbiology in Periodontal Health and Disease",doi:"10.5772/intechopen.75709",slug:"oral-microbiology-in-periodontal-health-and-disease",totalDownloads:2129,totalCrossrefCites:3,totalDimensionsCites:3,hasAltmetrics:0,abstract:"Oral microbial community is one of the most complex bacterial florae associated with human body. Up to now, more than 700 different bacterial species have been identified from human oral cavity. Oral bacteria form communities on distinctly different surfaces, such as hard enamel and cementum, as well as on soft epithelial cells. These communities are biofilms, which are characterized by their species composition, their surface or substratum composition, and the conditioning films coating the surfaces on which they form. The composition of the resident oral microflora shows local variations in composition on distinct surfaces (e.g., tongue, cheek, teeth) due to differences in key environmental conditions. Many studies have found that certain microbial flora may be compatible with a state of periodontal health and variations in oral flora is associated with varying degrees of periodontal disease. Information about the composition and the assembly processes of oral microbiota could be used to develop effective strategy and monitoring protocols for periodontal therapy.",signatures:"Nada Tawfig Hashim",downloadPdfUrl:"/chapter/pdf-download/61071",previewPdfUrl:"/chapter/pdf-preview/61071",authors:[null],corrections:null},{id:"60051",title:"Discriminating Life Forms in Oral Biofilms",doi:"10.5772/intechopen.75746",slug:"discriminating-life-forms-in-oral-biofilms",totalDownloads:1170,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:0,abstract:"The bacteria colonizing the hard and soft tissues of the oral cavity are known to significantly influence oral health and disease. Recent studies of subgingival dental plaque, based on different identification methods, provide direct evidence of substantial diversity of plaque microbiota. Till date only about 280 bacterial species have been isolated by cultivable methods, characterized and formally named out of this enormous microbial diversity of oral biofilms. As a consequence, there is a complete lack of information about the properties of a substantial proportion of the plaque microbiota, apart from their position in the taxonomic hierarchy of bacteria. This limited knowledge about the behavior and properties, combined with recognition of the considerable diversity that exists within individual species, raises serious questions to the foundations on which previous conclusions, concerning the etiology of periodontal diseases, rest. The emerging realization is it is impossible to fully understand oral health and disease without identifying and understanding the pathogenic potential of all of the bacteria that colonize the oral cavity. The current chapter shall provide an update on current status of oral microbiota, ecological significance of their biofilm life style and various methods to study microbes residing in oral biofilms.",signatures:"Vishakha Grover and Anoop Kapoor",downloadPdfUrl:"/chapter/pdf-download/60051",previewPdfUrl:"/chapter/pdf-preview/60051",authors:[null],corrections:null},{id:"61997",title:"Trojans in Oral Environments: Evidence of Molecular Mimicry in Oral Immunity",doi:"10.5772/intechopen.75747",slug:"trojans-in-oral-environments-evidence-of-molecular-mimicry-in-oral-immunity",totalDownloads:906,totalCrossrefCites:2,totalDimensionsCites:2,hasAltmetrics:0,abstract:"Oral microbiome possesses more than 1000 microbial species that co-exist with human oral cavity. However, when there is an imbalance in microbial ecosystem, infection and inflammation occurs. Chronic inflammation produces constant antigen-cell presentation and reactivity T and B cell results in an adaptive immune response with high specificity cell-cell and antibody response producing an autoimmune disease by molecular mimicry. In this chapter, using just BLAST, shows self-epitopes (autoantigens) from different autoimmune diseases such as Systemic lupus erythematosus, Sjögren’s syndrome, neuromyelitis optica, Stiff-Person syndrome, autoimmune diabetes, autoimmune thyroiditis, myasthenia gravis, autoimmune gastritis, autoimmune hepatitis, myositis and rheumatoid arthritis that possess similarities with microbial epitopes belonging to oral microbiome acting has a computer trojan occult in a software package.",signatures:"Gustavo Obando-Pereda",downloadPdfUrl:"/chapter/pdf-download/61997",previewPdfUrl:"/chapter/pdf-preview/61997",authors:[null],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"10221",title:"Bacteriophages in Therapeutics",subtitle:null,isOpenForSubmission:!1,hash:"96b799aada07c6e98864f2d8e5780bac",slug:"bacteriophages-in-therapeutics",bookSignature:"Sonia Bhonchal Bhardwaj",coverURL:"https://cdn.intechopen.com/books/images_new/10221.jpg",editedByType:"Edited by",editors:[{id:"178566",title:"Dr.",name:"Sonia Bhonchal",surname:"Bhardwaj",slug:"sonia-bhonchal-bhardwaj",fullName:"Sonia Bhonchal Bhardwaj"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"352",title:"Gingival Diseases",subtitle:"Their Aetiology, Prevention and Treatment",isOpenForSubmission:!1,hash:"012b0c5861d2250ac8aeaf385b2e1efe",slug:"gingival-diseases-their-aetiology-prevention-and-treatment",bookSignature:"Fotinos S. 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\r\n\tCryptococcosis, caused by the opportunistic yeast Cryptococcus neoformans or Cryptococcus gattii is an important cause of morbidity and mortality in persons immunocompromised by advanced HIV disease. Cryptococcal meningitis is the leading cause of meningitis among adults with sub-Saharan Africa. In addition, C. gattii has been responsible for major outbreaks in North America. There is a growing interest in the epidemiology of cryptococcal infection and disease in HIV-negative individuals, particularly in those with poorly controlled diabetes mellitus and recipients of solid organ transplants.
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Dr. Bongomin is actively involved in the teaching of both medical and public health students in various aspects of medical microbiology and immunology. He has authored over 50 papers and book chapters in the areas of fungal diseases. 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Its movement is reflected in the stock market indices that express the overall performance of the stock market or just a certain sector, and offers the investors the base of their investment decision on the markets. Therefore, the authors have proposed in this paper to summarize the results of research in order to highlight the most significant issues of the risk management on the Romanian capital market and to provide solutions to them.
The first part highlights the role of stock market indexes in describing the state of the capital market, as well as the difficulties arising on their representation in the current financial and economic crisis. In order to reduce the risk of erroneous information to investors, the authors propose a composite index that summarizes the information from other indexes on the capital market in Romania. Finally, using the Risk Grades method, the authors make a comparative analysis of the risks on the Romanian capital market with those in the Czech Republic, Poland and USA capital markets.
The second part outlines the main classes of risks that arise in the settlement of exchange transactions that dominate in the risk hierarchy of the stock operational management. After highlighting some international regulations on reducing the risk of stock trading settlement, the authors develop a broad range of solutions for reducing these risks on the Bucharest Stock Exchange.
In the economic literature, the stock exchange is often characterized as being a true "engine" of the economic life, which stimulates business activity and allows the development of large-scale investment projects. Through its existence and operation, the stock markets provide liquidity for financial assets, enabling the sale of securities previously purchased, thus turning them to money. Economic and financial crisis that has monopolized economies worldwide in recent years has had a negative impact on the development of stock markets. Thus, stock prices of large companies listed on stock exchanges fell dramatically, the liquidity of stock markets fell heavily, and on this basis, the transaction volume decreased due to the reduction of interest shown by investors and speculators. Indexes saw an overall decrease and
Expressing the overall performance of stock markets or simply of a sector of the market, indices allow investors to perform analysis on yields of already performed transactions or on investment opportunities that may arise in the future. The existence of indices make the analysis of various stock markets much easier, even if the different methodologies used for calculating the indices affect to some extent the comparisons accuracy [1-3].
On any stock market, the indices are a reference for each investor when assessing the quality of the management portfolio. Due to the fact that in many cases individual performance fail to exceed indices’ long-term growth rate, investors and fund managers especially were tempted to build their own portfolios using the precise structure and composition of the indices.
A first issue to be solved when considering the desirability of launching a stock index is if you choose to use a formula in the category of arithmetic or geometric average. Since the use of geometric replication creates difficulties when the stock index would be eligible as underlying for derivatives or as a benchmark for investment fund, managers will prefer to use a formula based on the arithmetic average.
Also, the option to use weights in the calculation of indices involves an analysis of market characteristics to be described by the respective stock market index. The decision to weight the prices which is part of an index is itself a controversial:
the supporters of the unweighted variant believe that such an index only ensures equal treatment of each stock symbol which is part of an index;
those who appreciate more weighted index say that the only way to avoid unwanted situation in which the relative change in price of shares issued by a company small in size will influence the stock index as much value as a change in the same type of the share price "Blue Chips".
Another issue that arises is the choice of the weighting factor. In theory there may be various options for the weighting factors, but in practice have won two:
weighting by market capitalization (or the amount of the outstanding shares);
weighting the liquidity of the shares that make up a stock index.
In the first case there is a risk that a relatively small number of companies - which have a market capitalization way above the market average - will decide the meaning and scope of developments in practice the whole index. It is a common situation in emerging markets. Therefore, it is often set a maximum level of the share capitalization of a single symbol that can play in the total capitalization of the symbols in the composition of a stock index.
In practice, the liquidity is the most common alternative criterion to using market capitalization as the weighting factor. Attractiveness of the weighted indices to the liquidity lies in the idea that virtually any listed price of a share is a fiction as long as it materializes through a stock transaction. Therefore, prices become relevant only insofar as they are the result of a large number of transactions, which require (at least at first) the use of liquidity as a weighting factor in calculating the indices. The disadvantage of using liquidity as a weighting factor consists, however, in the presence of many differences from one day to another in the number of shares made with a specific symbol, which significantly alter its influence in the evolution of the overall index [4-5].
In principle, a stock index is a tool for measuring aggregate price developments for the symbols which compose it, the sole result of supply-demand ratio of the market and the continuing process of reassessment of the price of each symbol individually [6-8]. Therefore is needed to incorporate the adjustment coefficients in the formula for calculating an index, allowing correction of artificial effects induced by certain events on the trading price of a symbol:
events which directly affect the trading price of a symbol: the provision of dividends, granting of rights to subscribe.
events that influence the number of shares taken into account: the change in share capital by increasing / reducing the number of the outstanding shares, split face value, strengthening the nominal value, granting free shares (bonus issues).
changes in the composition of a stock index: the inclusion of a new symbol, a symbol of exclusion.
Payment of the dividends or issuing of preference rights involves reducing the value of traded shares of a company, unless the subscription rights have value “zero” or negative. When providing payment of dividends and share trading, price decrease is due to reducing the company\'s value by the amount allocated for dividends, while the rights issue of preference allocation occurs due to the decreased value of the company on a number of shares. These decreases in market value of a share are fully balanced by increasing the same amount of portfolio investors as a result of amounts received as dividends or the sale of preference rights indices as a result of the above events has the advantage of simplicity, though in practice most indices are adjusted when there are such price changes.
Assuming that the granting of a certain amount as dividend per share produces a decrease in the share price with the exact amount of the dividend, the adjustment procedure will require adding value to the price of the stock dividend is taken when calculating the indices. Otherwise, you can use an adjustment factor, multiplied by the share price is taken when calculating the index.
In the construction and management of indices there are other critical elements, which primarily aim to adapt to the concrete conditions of the stock market that they are going to describe. One such factor is the choice of a
In the case of adjusted indices, selecting a large number of shares to be part of an index basket involves assuming the possibility of relatively frequent cases of adjustment, thus reducing the transparency index. Also, a too extended composition raises serious problems for managers who use index funds as a "benchmark" or which suggest as investment strategy to make investments in securities index.
If an index is used as underlying assets for the development of financial derivatives, its composition becomes more important. It is desirable that the selected symbols, especially those with high weight in the index, have a sufficiently high level of liquidity in order not to influence the price with the idea of obtaining a more favourable settlement value of futures contracts or options. The issue of settlement value of derivatives that are underlying indexes has been addressed and in terms of prices that are taken in calculating its value at the close of trading session. Intuitively, the last price recorded in a day by a certain symbol should generate and last values of stock market index. To avoid forcing the closure of certain levels of price indexes, administrators have considered closing the option that its value is determined either as the average of past values of the index calculated based on average prices in a given period time for each symbol in its composition. This concern for the accuracy of the closing price of the shares and hence the value of stock index led some stocks to decide to introduce at the end of the trading session of the tender period in which prices are determined on a multilateral basis, through a fixing algorithm.
Through the changes that were made in time upon the methodology of calculation and management of indices, the Bucharest Stock Exchange (BSE) showed that it understands their importance for the investors and the general public. However, according to the authors, there are still some aspects in the functioning of the indices in the future, as changes might occur, so that the indices calculated by the BSE to increase their representativeness and to become more attractive tools for use as benchmarks in management activity portfolio.
The first change is imposed by the profile described by the historical values of the indices. As it may be seen on Figure 1, joining the five indices calculated by BSE in the same graphic deprives us of any opportunity to make a comparison. This is obviously due to objective factors, as as BET, BET‐C, BET-FI, BETXT and BETNG were launched from different basic data. Moreover, the BET and BET-C had worked in a period when inflation was very high and the national currency exchange rate at the time of their release was lower than the current one.
Therefore, it is required the denomination of all the BSE indices, so that on a specific reference date to have the same value for all indices. Bringing all indices at the same amount for a certain date, would open the way for a much easier tracking trends and comparison of their indices and market sectors they represent.
BSE indices (denominated) in January 2007-8 September 2009
To achieve this denomination, an important element consists in determining
Once the indexes are denominated, it appears the following problem consisting in identifying their new
Another problem to be solved is to develop a synthetic stock index describing the overall market share in Romania, as the Bucharest Stock Exchange also calculates a number of indices for Rasdaq: RAQ-I, RAQ-II and RASDAQ-C (which is a composite index).
One of the main concerns of a stock market operator is to identify the most effective means by which information about the activities of the regulated market that he manages, reaches the participants, from potential investors or the general public. Indexes are highly effective tools in promoting or communication, and that is why special attention should always be given to their management. Regardless of the methodology used, the scope or the "brand" adopted, the indexes must reflect as closely as the stock market developments in a given period of time, and the investors and the general public should recognize this status. Therefore, we believe that the stock market in Romania would be even discussed whether to outsource the work associated with the major indexes by a specialized international company to calculate and disseminate indexes. Market indexes license is highly specialized, with a relatively small number of participants. Therefore, "rebranding" of BSE indices under the name of one of the leading players in this market (Dow Jones, FTSE or MSCI) it would significantly increase the international exposure of local indexes.
Currently, the shares of the Romanian companies are traded in two distinct market sectors (BSE - regulated market and Rasdaq), with the chance to add another market (alternative trading system). For historical, but also technical reasons, the two market sectors are currently covered by two families of indices:
Therefore, as stated, there is not a single synthetic indicator to describe the evolution of prices in the two market segments. Furthermore, in the "BET index family" there is a composite index, BET-C that does not include in its membership the five SIF symbols. So, even the most comprehensive index of the regulated market does not include the five most liquid stock market symbols, which normally accounts for almost half of the total transactions on the BSE [9].
That is why, it is necessary to create a more comprehensive stock index, which describes the overall evolution of the quotations for all shares traded on markets and market sections administered by the BSE. A possible name for this could be ALL-X, and that structure will be an "index of indices".
Once the objective is defined and the name is established, the next step is to clarify the composition of such an index, so there is no overlap, but at the same time to remain as few "areas" uncovered as well. From the analysis of the five indices of the “BET family” and all three of the "RASDAQ family” it is very clear that the optimal variant is that the composition of ALL-X to enter the next three BSE indices:
Regarding the topic, the fact that the Rasdaq-C index is calculated at the end of the trading session (and not in real time) also requires that the ALL-X index to be calculated with the same frequency.
Also, the type of formula chosen is relatively simple, since all three indices (I
For the price index, the most frequent weighting factors (Pi,t) are either capitalization or liquidity. Since all of the three indexes found in the composition of ALL-X are capitalization-weighted price index, at least apparently the natural alternative is to use the same weighting criteria: capitalization. Moreover, the choice of the capitalization weighting factor ensures that the advantage of not requiring frequent rebalancing for an investor who decides to adopt a passive investment strategy in relation to the ALL-X index.
Through its coverage, the ALL-X index will create replication difficulties. Therefore, in its construction, the focus should be on its descriptive issues and less on the investment. Consequently, it becomes important to find a variant that takes into account the weighting of liquidity, which has the disadvantage that the index can cause daily changes without evidence of membership to undergo changes, or changes in scope than the other induced increases or decreases in the BET-C index, BET-FI and Rasdaq-C. Such a compromise version could be given to the establishment of fixed predetermined weighting factors, which remain unchanged for a defined period of two consecutive data adjustment index ALL-X (one quarter).
In calculating these predetermined weighting factors, both the capitalization and liquidity will be taken into account. The formula for calculating the determining factors will be:
where:
To ensure a unified form to display all BSE indices, will opt for the next version of the equivalent representation:
where:
To ensure the possibility to compare the new ALL-X index with the main stock market index, BET, the start value will be 2901.10 points and the start date will be fixed for 31.12.2008. The calculation of the weighting factor, Pi,t, will be done quarterly, on the last trading day of the final month of the quarter, and will enter into force on the first trading session of the next quarter [10].
The main advantage of building the index ALL-X is that it can be obtained a simple and effective tool to provide an overview of the entire stock market development in Romania. The index is limited to the evolution of shares issued by the Romanian companies, while any direct influence induced by the prices movement of foreign securities admitted to trading on domestic capital market was being removed from the beginning.
In the presented form, ALL-X index is defined primarily as a descriptive index and less like an investment. This deficiency can be corrected later, to the extent that the BSE will decide to use the same calculation methodology for all its indices, regardless of the section or market segment that is addressed: regulated market, Rasdaq market or alternative trading system. Moreover, in order to emphasize the character of investment, it will be necessary to modify the weighting factor (which may become the capitalization of each index), as well as the dates when its new value is calculated and effective.
To calculate the ALL-X index values retrospectively, after the release date was determined (December 31, 2008) and the reference value at that time (2901.10 points), the first step is to determine the Ui and Vi factors for the first quarterly interval (January-March 2009). To this end it will determine:
capitalization associated to the symbols in the composition of the BET-C index, BET-FI and Rasdaq-C on the last trading sessions of December 2008, March 2009, June 2009, September 2009 December 2009, March 2010, June 2010, September 2010 and December 2010 (RON);
25,441,147,900 | 1,715,098,084 | 12,099,865,129 | |
20,494,699,824 | 1,473,851,929 | 11,799,297,770 | |
28,577,557,323 | 2,276,366,573 | 12,359,818,473 | |
35,329,737,297 | 3,454,691,266 | 12,868,187,477 | |
35,313,895,995 | 3,264,425,651 | 12,346,442,408 | |
46,106,028,659 | 4,391,516,633 | 14,104,548,987 | |
36,894,347,800 | 2,715,614,092 | 11,065,581,044 | |
41,488,093,266 | 3,282,932,587 | 11,556,865,887 | |
41,901,691,868 | 3,004,035,475 | 10,832,645,290 |
Capitalization associated to the symbols in the composition of the BSE indices
liquidity (total amount in RON) associated to the symbols in the composition of the BET-C index, BET-FI and Rasdaq-C in Quarter IV 2008, Quarter I 2009, Quarter II 2009, Quarter III 2009, Quarter IV 2009, Quarter I 2010, Quarter II 2010, Quarter III 2010 and Quarter IV 2010 (RON).
435,647,850.34 | 468,296,885.00 | 186,402,641.20 | |
423,175,985.74 | 203,780,032.70 | 86,885,606.44 | |
668,823,417.53 | 658,946,311.40 | 102,202,564.63 | |
600,539,594.05 | 728,518,117.60 | 94,069,608.81 | |
485,044,466.85 | 691,750,042.50 | 113,518,426.21 | |
691,952,816.70 | 735,425,007.50 | 148,602,226.21 | |
695,515,698.95 | 1,039,348,556.50 | 130,801,236.36 | |
331,670,219.85 | 407,212,194.50 | 57,407,872.87 | |
352,178,129.60 | 304,259,023.50 | 87,486,365.49 |
Liquidity associated to the symbols in the composition of the BSE indices
Based on the data presented in the previous tables, we will calculate the following elements:
weights associated with each index in the total capitalization for each final quarter;
64.81 | 4.37 | 30.82 | |
60.69 | 4.36 | 34.94 | |
66.13 | 5.27 | 28.60 | |
68.40 | 6.69 | 24.91 | |
69.35 | 6.41 | 24.24 | |
71.37 | 6.80 | 21.83 | |
72.81 | 5.36 | 21.84 | |
73.65 | 5.83 | 20.52 |
Weights associated to the BSE indices in total capitalization (
weights associated with each index in the total liquidity for each quarter;
39.95 | 42.95 | 17.10 | |
59.28 | 28.55 | 12.17 | |
46.77 | 46.08 | 7.15 | |
42.20 | 51.19 | 6.61 | |
37.59 | 53.61 | 8.80 | |
37.28 | 55.71 | 7.01 | |
41.65 | 51.14 | 7.21 | |
47.34 | 40.90 | 11.76 |
Weights associated to the BSE indices in total liquidity (
Once the weights are determined, it will be necessary to calculate the weighting factors in the composition of each ALL-X index for each quarter:
Ui | Vi | Ui | Vi | Ui | Vi | ||||
0.6481 | 0.3995 | 0.0437 | 0.4295 | 0.3082 | 0.1710 | ||||
0.6069 | 0.5928 | 0.0436 | 0.2855 | 0.3494 | 0.1217 | ||||
0.6613 | 0.4677 | 0.0527 | 0.4608 | 0.2860 | 0.0715 | ||||
0.6840 | 0.4220 | 0.0669 | 0.5119 | 0.2491 | 0.0661 | ||||
0.6935 | 0.3759 | 0.0641 | 0.5361 | 0.2424 | 0.0880 | ||||
0.7137 | 0.4391 | 0.0680 | 0.4666 | 0.2183 | 0.0943 | ||||
0.7281 | 0.3728 | 0.0536 | 0.5571 | 0.2184 | 0.0701 | ||||
0.7365 | 0.4165 | 0.0583 | 0.5114 | 0.2052 | 0.0721 |
Weighting factors Pi,t
Evolution of the ALL-X index vs. Evolution of BET index (Jan. 2009 – Dec. 2010)
The biggest weight in the ALL-X index is given by the BET-C composite index. The values of Pi,t associated with the BET-C for the full period 2009-2010 ranged between 0.5 and 0.6 percent.
Stock markets investors constantly face several risks, which is why researchers have focused their concerns on issues related to developing risk management improved models of assessment and management. Among the latest methods used in economic practice in assessing risk in financial markets the method
Risk Grades indicator provides a synthetic image of the risk associated with a certain financial security, a portfolio or an index. This new way of measuring volatility is based on exactly the same data and analysis as VaR, while making it possible to translate the Risk Grades estimates in terms of VaR. Furthermore, Risk Grades methodology is intended to be more intuitive and easier to use than VaR. The characteristics of the Risk Grades are:
It is a dynamic method of measurement that adjusts to the market conditions
Allows comparison between different investment classes, regions and different areas, is a standardized method of measuring volatility
Allows comparison of different market indices.
The Risk Grades formula for the financial asset
where:σi the volatility of the financial asset
σbase the base volatility
Evolution of DJIA between 1 Jan 2006 – 30 Dec. 2010
To determine the Risk Grades values associated to the main indices calculated by the BSE (BET, BET-FI, BET-C) it will be considered a decay factor λ = 0.98, which corresponds to a minimum number of records n = ln (0.1)/ln (λ) of 113. The series of values for indexes is 1 January 2008 to 30 December 2010 and the index used as reference for determining the Dow Jones Industrial Average (DJIA) is σbase.
We can notice in the above chart the negative effects of the financial crisis that occurred on the DJIA mainly by early 2009, when the North American stock market indexes registered multi-minimum (on 9 March 2009, the DJIA was calculated for 6547 points). Choosing the interval 1 January 2009 to 30 Dec.2010 for the series of values Risk Grades indices used in the calculation took into account to cover both a pronounced downward trend of the DJIA index and an increasing trend after March 9 2009.
Risk Grades values for BSE indexes between 21 May 2009 - 30 Dec.2010
The Risk Grades values determined for the BSE indexes confirms that the Romanian capital market is riskier than the North American capital market. Besides that, as one can notice from the above chart, the Risk Grades values of the ALL-X index are consistently positioned below the BET-FI sector index and above the associated BET and BET-C.
If decay factor λ = 0,96 was chosen, the minimum number of records that we need is 228, sufficient for our purpose, consisting in comparing the risk associated with the capital market in Romania with those determined for other international stock markets or within the region.
In order to make a comparative analysis of the risks on the Romanian capital market and the main indexes of the Central and Eastern Europe we took into consideration the main indexes of Poland and the Czech Republic capital markets, meaning the WIG20 and the PX.
The
The
Risk Grades values for the main indexes in the region between 21 May 2009 - 30 Dec.2010
When comparing the Risk Grades values of WIG20 index of the Warsaw Stock Exchange and of PX index of the Prague Stock Exchange with those of the Romanian Stock Exchange (see figure 5), we reach a surprisingly conclusion, that the Risk Grades values calculated for the main indexes in the Central and Eastern Europe do not show major differences. Although constantly the Risk Grades values are above those associated with the WIG20 and PX index, the difference is very small [12].
The risks managed by Institutions such as market operators, clearing houses and central depositories are not less important, but are maybe less visible to the public.
It is known that stock market transactions are followed by a mutual transfer of ownership from seller to buyer, and the amount of money equivalent, from buyer to seller. Clearing and settlement take into account that transfers of financial instruments and financial funds between parties are to be performed safely and with little cost.
To prevent and to reduce the risks specific to the settlement of financial instruments transactions, direct access to clearing and settlement system is limited to those participants who meet a set of capitalization criteria, operational capacity and professional experience, which means that the settlement of an exchange transaction involves a given number of financial intermediaries. The more financial intermediaries are involved in the settlement of financial instruments transactions, the more complex is the settlement process.
Clearing and settlement process begins immediately after a transaction with financial instruments is closed and goes through the following main steps:
The settlement itself, which is composed of:
The last stages of the settlement imply the highest financial risk throughout the process of finalizing exchange transactions, one of the main criteria that measures the performance of a clearing system and securities settlement transactions refers to the method the connection between the mechanism of transfer of securities (obligation to deliver) and transfer mechanism of funds (payment required) is made. The systems within which the permanent transfer of securities are to take place, subject to an exchange transaction, only if the final and irrevocable payment of amounts is made, fulfilling one of the main conditions to measure performance: delivery versus payment (Delivery Versus Payment - DVP). By using mechanisms that ensure DVP, one eliminates the most important component of all financial risks that accompany the settlement of transactions with financial instruments: principal risk.
As presented before, between the moment a transaction with financial instruments is closed and the ownership transfer certain stages are to be completed in a given time frame. The following risks are present and occur:
Depending on the structure of clearing - settlement systems and transaction type, there might also be other risk categories, such as bankruptcy risks of the settlement bank, legal risk or custody risk. The probability that one or other of the above risks could materialize depends substantially on the following two main factors:
implementation of strict procedures to control risks in the clearing and settlement of securities transactions, procedures known collectively as "risk management";
operation plan of the clearing and settlement system of transactions with financial instruments.
Materialization of risks in clearing and settlement operations may have significant negative influences on a country\'s entire financial system [13].
Moreover, given the internationalization of financial flows, where some of the affected participants in a clearing and settlement system operate simultaneously in multiple markets or operational links exist between two or more national clearing and settlement systems, this may cause contamination and spread of local problems internationally. Thus a set of recommendations was elaborated by specialized international institutions.
“G30 Recommendations” consists of a set of nine recommendations that should be implemented by all settlement systems:
Confirmation of all transactions must be achieved by all direct participants in the market (for example: brokers/ brokers/dealers and other members) in T+0. Details of all confirmed transactions must be transmitted to clearing – settlement system.
Indirect market participants (e.g. institutional investors) should be informed on the implementation details of transactions in T +1.
Every country should have an operational central securities depository, organized and managed so as to encourage activity of the direct and indirect market participants. The range of financial instruments eligible to be registered in the central depository must be broad. Preserving or dematerializing financial instruments should be as extensive as possible. If on the same market there are several depositors, they should operate on the basis of compatible rules and practices, in order to reduce settlement risk and to allow use of funds and make available any financial securities pledged as collateral in an efficient manner.
Each market should be encouraged to reduce settlement risk by introducing "gross settlement in real time" mechanisms (Real Time Gross Settlement - RTGS) or by using compensation based on transactions that meet Lamfalussy recommendations.
DVP system should be used as a method of settlement for all transactions. DVP is defined as "simultaneous dismissal, final, irrevocable and immediate securities and funds continuously throughout the day."
Payments related to settlement of securities transactions and using a financial instrument portfolio should target all markets and financial instruments, the adoption of the "Same day fund" Convention.
A single cycle of implementation of the settlement should be adopted for all markets. Final settlement for all transactions should be made no later than T +3.
Loans of financial instruments should be encouraged as a method of developing financial instruments transactions settlement. Barriers and taxes that limit loan of financial instruments should be removed.
Each country should develop a standard for messages related to financial instruments based on ISO Standard 7775. In particular, each country should adopt the ISIN coding system for securities, as specified in ISO Standard 6166.
CPSS (Committee on Payment and Settlement Systems) - IOSCO (International Organization of Securities Commissions) recommendations, completed in 2001, take and develop provisions of G30 recommendations, adapting them to the important changes occurring in the securities industry in recent years, but adding new ones.
The legal system: the settlement of transactions with financial instruments must have a solid legal framework, clear and transparent.
Confirming transactions: Confirming transactions between direct market participants should be completed as soon as possible after the time transactions are executed, but not later than the end of the trading day (T +0). When it is necessary to confirm the transaction by indirect market participants (such as for institutional investors or global custodians), it must take place as soon as possible after execution of the transaction, preferably "T 0", but not later the "T +1".
The settlement cycle: settlement transactions mechanisms must adopt the system by which the value date is set after a specified number of days from trade date ("rolling settlement system"). Final settlement must be made no later than "T +3". Costs and benefits of a shorter settlement cycle than "T +3" should be carefully evaluated.
Central counterparty (CCP): costs and benefits of central counterparty mechanism should be evaluated. The introduction of this mechanism should always be accompanied by control of risk assumed by the institution which provides central counterparty services.
Loan instruments: lending of financial instruments (REPO contracts or other equivalent transactions) should be encouraged to streamline the process of settlement of transactions. Barriers that inhibit the use of loan activities for this purpose should be eliminated.
Central Depository (CSD): Preserving or dematerializing of securities and their transfer through electronic registration account must be used as widely as possible.
Delivery versus payment (DVP): CSDs should eliminate principal risk by linking the transfer of financial instruments and transfer of equivalent financial funds so as to achieve delivery against payment (DVP).
Complete Settlement: Completion settlement must take place no later than the end date of settlement. Successful settlement on the basis of a real-time settlement mechanism should be considered.
Risk control: CSD providing credit facilities to participants, including CSDs that operate net settlement systems, should establish control of risks, ensuring at least successful settlement if the participant with the largest payment obligation can settle the payment. The best way to control risks involves the adoption of a set of measures that combine the use of collateral to limit exposure.
Settlement money: Assets used for last payment obligation securities transactions should carry little risk or not be at all affected by credit risk or liquidity risk. If settlement scheme does not involve any use of central bank resources, measures should be taken to protect settlement system members of potential losses and liquidity constraints that may occur due to risk cash settlement agent used to complete transactions with financial instruments.
Operational Safety: Sources of operational risk arising in the clearing and settlement should be identified and minimized by adopting an appropriate architecture for the system, through control and adoption of specific procedures. Systems must be safe and have adequate capacity. Action plans and emergency back-up should allow recovery of data and timely completion of settlement.
Protect investors’ portfolio: Entities that have custody of financial instruments must use specific procedures to ensure full protection of investors\' portfolio. It is essential to have investors\' portfolios protected from creditors\' claims on the entity that retains custody of financial instruments.
Access: CSDs and CCPs should have objective and transparent criteria established for participants, allowing fair and open access to the system.
Efficiency: Without affecting operations safety, securities settlement systems should ensure efficiency in terms of costs incurred by participants.
Communication standards and procedures: settlement systems securities transactions must use or adopt procedures and standards to facilitate communication to facilitate efficient cross-border transactions. Providing conditions for all participants to communicate in a fast, safe and clear manner is of the outmost importance for the functioning of clearing and settlement systems. It is therefore recommended for all participants in the system to know and to use standard procedures in relation to the messages content, securities identification or other participants. In cross-border transactions is advisable to use international standards: ISO 6166 and ISO15022.
Transparency: CSDs and CCPs should provide participants enough information for them to identify and evaluate risks and costs of using services provided by the central depository and central counterparty.
Supervision: settlement systems securities transactions should be subject to transparent and effective supervision. Central banks and capital market supervisory authorities must work together or with other authorities with competence in the field.
Risks associated with trans-border connections between central securities depositories. The CSD that establish inter-connections with another CSD to make cross-border transactions must design and operate such connections so as to reduce specific risks of cross-border settlements. Cross-border transactions carry most of and the most complex risks that you may encounter when conducting capital market investments. Besides, the costs of performing such transactions are not reduced. To reduce risks and costs involved in carrying out cross-border transactions of financial instruments that otherwise would be borne solely by investors; institutions responsible for the successful settlement of the different countries were involved in establishing relationships to facilitate these operations. Achieving inter-connections between different systems operated by Central Depository make life easier for cross-border investors, but involves close monitoring of such risks if transferred from investors to administrators of clearing and settlement systems.
The services traditionally offered by stock exchanges refer to admission to the stock exchange of the issuing companies, establishing criteria for maintaining a particular security traded, disseminating for the public such stock exchange market information, especially for ensuring mechanisms to concentrate liquidity for a particular security. But continuously exchanges were directly interested in the whole building technical and institutional infrastructure to ensure safe completion and cost of transactions traded on the stock market. Therefore, some scholarships have created their own departments through which to work out the full range of post trading: clearing, settlement and registration. This was the case with the Bucharest Stock Exchange, which since the resumption of operations (in 1995) has provided all operators on the stock market clearing and settlement services [14].
For settlement of stock exchange transactions, BSE chose from the beginning a variant of Model 2 settlement, which requires multilateral clearing and final settlement of funds applied to the net basis, followed by settlement of securities traded, settlement being applied to the gross. The modular structure of the electronic system of BSE that includes trading module, clearing and settlement module and registry module allowed real-time interaction between each of these components, which provided a minimum exposure of the system to operational risk. The settlement cycle used in the stock market in Romania is "T +3" and the final settlement of funds is performed in a separate section of the national payment system (ReGIS), BSE being authorized by the NBR as a inter-banking clearing house since June 9, 1997.
This brief presentation of the clearing and settlement of BSE is only an overview of its main features without revealing all relations established between participants on the stock market from the moment the transaction was closed on the exchange floor until settlement, meaning until the buyer settles all payment obligation according to the contract and the obligation to deliver the securities according to the contract stipulations, accrued to the buyer. To facilitate understanding of information flow that constitutes the transaction settlement system on the BSE it is useful to first review the following terms:
Bucharest Stock Exchange is at the heart of the whole system of securities transactions settlement concluded on the stock market, interacting with each of the participants in the system:
Information flow and all the activities leading to successful settlement is achieved over three days (T +3). Presented sequentially, the process is done through the following steps:
After the trading session is closed, the Stock Exchange prepares the Compensation Report and the Settlement Report related to securities transactions executed by each intermediary. Intermediaries and custodians registered with BSE agents are required to confirm the next day, the contents of clearing and settlement reports.
BSE will issue and send by fax with delivery receipt or secured e-mail to the clearing participants (settlement banks) all bank settlement reports.
Participants in the clearing and settlement system managed by BSE are required to check the reports taken from BSE system. If participants in the clearing and settlement system managed by BSE object to the reports, they will communicate this in writing to BSE. After complaints are settled by BSE staff and reports are amended by BSE, documents and operations resume the circuit described above and the brokers modified reports, custodians and that participants will be forwarded by the BSE in the same day. If no objections are raised regarding the data presented in the reports provided by BSE, these are considered to be confirmed.
On transaction settlement date (T+3), debtor clearing participants will confirm BSE their consent to participate in the settlement, according to the amounts recorded in the Bank Settlement Report, by fax with delivery note or secured e-mail system. Also, participants will set up deposits equal to the net amount to be paid, in ReGIS in favour of BSE.
Based on the final Settlement Balance, BSE will initiate the payment instruction to settle all net positions.
National Bank will confirm to Bucharest Stock Exchange that final settlement was concluded by sending the document “Settlement report of net positions”.
After payment confirmation is received, BSE will transfer financial instruments from the sellers’ accounts to the buyers, according to the concluded transactions. This will be accompanied by sending a message confirming to all clearing participants that settlement transaction was closed.
Workflow described above is one in which all intermediaries and settlement system clearing participants honor their obligations that arise from the exchange transactions. Efficiency of clearing and settlement system is checked, but especially when during the settlement cycles a situation where one (or more) of the participants in the system cannot fulfil obligations. To prevent such situations and to solve them when they manifest, clearing and settlement system of the BSE has established a risk management mechanism.
Risks that can disrupt the transactions settlement flow have been identified both at the level of the brokers and custodian (first layer) and the clearing participants (second floor). Consequently, risk management measures are structured on two levels:
Risk management measures managed exclusively by BSE;
Risk management measures managed together with NBR.
The main instruments to manage risk, available to BSE are the following:
In order to limit default exposure on brokers’ obligations, BSE sets through procedures a trading limit for each broker.
To limit exposure in case of no payment, BSE ask from clearing participants and brokers to give priority to clearing and disbursement of amounts necessary to cover their debit positions.
If it is found that upon settlement date, the participant to the clearing and settlement system managed by BSE has limited solvability to cover payment obligations, the clearing participant with whom the broker holds an account may proceed to grant credit, under an agreement signed in advance.
If the clearing participant grants participants in the clearing and settlement system managed by BSE a loan needed to cover the debit position, the participant in the clearing and settlement system managed by BSE was in position debtor may proceed to establish a claim pledge of financial instruments existing own account, both those settled, and of the pending settlement in favor of the credit granted. Clearing participant is required to present BSE documents stating the guarantee institution.
If the participant does not grant credit or the loan does not fully cover the debit of participants in clearing and settlement system, than BSE shall be able to call the Guarantee Fund.
BSE applies risk management measures as presented above. However, it should be noted that enforcing trading limits to each participant and using the amounts from the Guarantee Fund are the measures with the greatest impact on the entire system thus helping BSE to control risks in the settlement system
The trading limit is the maximum amount limit within each of the participants on the market regulated by BSE can operate over a single trading session. This limit is calculated in real time by the electronic system of BSE, for each intermediate, being affected by each completed transaction and not by the orders entered into the system by the participant. The trading limit is determined by a calculation formula and is affected by exchange transactions concluded on their own by each participant, both on their own name and on behalf of clients.
The formula for calculating the trading limit is as follows:
where:
During the trading session, each time a participant concludes a transaction, the Stock Exchange electronic system checks that the following formula is applied:
where:
To determine the trading limit, participants are required to submit monthly to BSE’s specialized department "Minimum net capital and indebtedness indicators statement" This statement will be sent to BSE within 10 working days from the end of the reporting month. If, during the time between two successive reports, the net capital varies more than + / - 15% compared to the last reports, the participant is required to communicate to BSE the new value immediately.
If during a day, the transactions concluded by a participant affect the relationship of inequality, the participant exceeding his trading limits, the Exchange system will not allow the introduction or modification of the exchange orders on behalf of that participant, as their execution would lead to increase his exposure, and orders that are already in the market will be suspended automatically by electronic system of BSE. Basically, if a participant that has completed operations which no longer meet the inequality relationship described above, will not be allowed to the market access till increasing the trading limit. In order to increase the trading limit is however necessary that the participant expressly requests this by sending a form by fax to BSE in this respect, also assuming responsibility for carrying out the settlement. However, the participant shall submit an estimate of the value of transactions he intends to carry out during the day when the limit was exceeded.
In time, the usefulness of trading limits and especially the formula used to calculate it attracted much discussion at the level of the stock market participants. The main criticism concerns the fact that on the right side of the relationship of inequality the sales and purchases amounts made on behalf of clients are treated similarly and influence the limit in the same way. Even if by making a sale transaction the intermediary does not assume any risk regarding the cash settlement of transactions, however the value of sales transactions made on behalf of clients diminishes daily trading limit of the participant. In fact, you can even consider that sales transactions made by a participant does not induce any risk in the entire settlement system as long as before being accepted an order of sale by the Exchange\'s electronic system, in the account of the seller are performed verification of the securities, subject to trading order. Considered from the perspective of market participants and given the above considerations, the current formula for calculating the limit of transaction seems unduly restrictive. Intuitively, the limit of transaction reported only net amounts paid in settlement appears to be more reasonable and would create a much closer relationship of emerging risks into achieving financial settlement to the Guarantee fund.
As required by the regulations and procedures Bucharest Stock Exchange, "The Guarantee Fund”, "the Fund ", has as main objective to ensure necessary resources for proper functioning of the mechanism of settlement of exchange transactions."
Sizing the Guarantee Fund and its constituent sources represent, for any settlement system, two central problems whose solutions can be found only by reference to at least the following elements:
Settlement model used;
Costs of setting up such a fund guarantee, costs supported mainly by direct participants in the settlement system;
Financial strength of the participants in the system, which is closely related to the overall stock market development;
The value of the transactions made on the stock market;
The performance of the compensation system (the degree of compensation), which ultimately generates the size of the exposures to settlement;
Other regulations of risk management;
Accepting that, in fact, financial risks are minimized and in very few cases are complete eliminated.
As explained earlier, for settling the exchange transactions, Bucharest Stock Exchange is using a variant of Model 2 Settlement (BIS classification), which requires multilateral clearing and final settlement of the funds on a net basis, followed by gross settlement of securities. For such a system, in the literature were directed two ways of determining the optimal value of a Guarantee Fund:
For net settlement systems, there are six minimum requirements to be fulfilled. The fourth requirement of this report states that "
Another opinion is that the minimum requirement to be greater than or equal to the number of days of the settlement cycle (for BSE, three) plus one, multiplied by the greater of the net debtor position recorded in a recent period of time, e.g. last two weeks.
As these recommendations suggest, the total amount of the Guarantee Fund has no absolute meaning, but must be interpreted in light of the whole system of risk management, value of transactions made on the stock market and especially the amount of exposure to settlement. These considerations were taken into account when establishing criteria for setting up and functioning of guarantee fund for settlement of negotiated transactions to BSE.
Guarantee Fund of BSE was established based on initial contributions of all members of the Stock Exchange Association (later, with the transformation of BSE in a stock company, any intermediary agent, carrying out transactions at BSE became eligible to participate in the Guarantee Fund) as well as of all custodian agents authorized by the Stock Exchange.
For the Guarantee Fund to be effective and achieve the purpose for which it was created is necessary that the component assets to have a high degree of liquidity. Therefore, in managing resources in the Fund should be prioritized the safe and liquid investment criteria, the yield obtained in the administration of the Fund represents only a secondary criteria.
To increase the accuracy which describes the development of the stock exchange in our country, it is necessary to build a synthetic index. Regarding the risk on the capital market, Risk Grades values determined for BSE indices show that the domestic capital market is more risky than the North American market.
However, analyzing the Risk Grades values obtained for all indexes in the region we notice that they are very close and shows that the investors are not picking up the capital market in Romania as an excessively risky relative to other exchanges in the region. It confirms the hypothesis that the main problems of the capital market in Romania are not related to demand, but derive primarily from an inadequate supply.
The risks managed by Institutions such as market operators, clearing houses and central depositories are very important, even though there maybe be less visible to the public. Clearing and settlement services ensure that transfers of financial instruments and financial funds between the parties of an exchange transaction to be performed safely and with low costs.
In order to prevent and to reduce the risks specific to the settlement of financial instruments transactions, direct access to clearing and settlement system is limited to those participants who meet a set of capitalization criteria, operational capacity and professional experience, which means that the settlement of an exchange transaction involves a given number of financial intermediaries.
Since the highest financial risk throughout the process of finalizing exchange transactions take place in the last stage of the settlement process, an essential role is associated to the way the connection is made between the securities transfer mechanism (obligation to deliver) and the funds transfer mechanism (payment required). By using mechanisms that ensure Delivery Versus Payment (DVP), one eliminates the most important component of all financial risks during the settlement of the financial instruments transactions that is the principal risk. In order to limit the exposure to the risk of default of the intermediaries’ obligations, a trading limit is set for each intermediate part.
Furthermore, the BSE requires its participants to prioritize the amounts necessary to cover their redundancy payment positions. From the market participants’ perspective, the current formula for calculating the transaction limit seems unduly restrictive. Intuitively, calculating the transaction limit based only on the net amounts paid in settlement appears to be a more reasonable assumption and could lead to a much closer relationship between the risks emerging in financial settlements and the guarantee fund. Meanwhile, for the Guarantee Fund to be effective and to achieve its purpose for which it was created it is necessary that the assets within it to have a high degree of liquidity. The transition process and the recent international financial crisis have significantly affected not only the evolution of stock markets in Central and Eastern Europe, but also significantly changed the outlook for their future development.
That is why the stock market management should not only consider short-term measures in order to mitigate the crisis impact, but also to try to ensure the prerequisites for further development. The improvement of stock management in general and of stock market risks in particular, requires a medium to long-term perspective, similar to the opinions and contributions formulated by the authors in this chapter.
Canned foods were well known and widely used for feeding the armies since the mid-eighteenth century. Nowadays, they play a crucial role in the everyday nutrition of everyone all over the globe, where they provide food with good quality that can last for a long time compared with fresh food. The canned food production industry, as any other industry, includes material processing, storing, and transportation. These activities lead to waste and emission generation and can affect the environment negatively if not well planned and applied. These negative effects might include air and water pollution and soil contamination. Of the major pollutants generated by this industry, the organic pollutants are very crucial [1].
In general, food processing from raw materials requires large volumes of high-grade water, which will become wastewater after usage. In particular, it requires a large volume of potable water for several usages, e.g. raw materials cleaning, fluming, blanching, pasteurizing, processing equipment cleaning, and cooling of the final products. These vast usages require the enforcement of quality criteria for the water used in each application; the best quality usage often requires independent treatment to assure complete freedom from odor and taste and to ensure uniform conditions [1]. The wastewater effluents from this industry are characterized by their large volumes. On average, some 10–20 m3 wastewaters are produced per tonne of products. The precise characteristics of these wastewaters are highly dependent on the performed processes during the canned food production, i.e. the process of vegetable washing leads to the generation of wastewaters with high loads of some dissolved organics, and particulate matter [2].
The organic content in the wastewater generated as a result of the operation of different processes in the food canning industries is characterized by high concentrations of biodegradable contaminants and variable pH levels. When an environmental reservoir, e.g. a stream or waterway, receives these wastewater effluents, the organic pollutants will consume some of the dissolved oxygen (DO) that exists in the reservoir during their stabilization. This will reduce considerably the DO to levels below that required for the sustainability of lives of the aquatic organisms. The extent of pollution caused by these effluents can be characterized based on the plant capacity, the utilized process, and the characteristics of the raw materials. In this respect, it is beneficial to categorize the plant capacity in terms of population, where seasonal plants are likely to generate waste loads equivalent to 15,000 to 25,000 people, and large plants generate loads up to 250,000 people. The processing of fruit and vegetables is one of the sources of wastewaters, which contain organic matters. Fruit and vegetable canning companies generate wastewaters with high levels of biochemical oxygen demand (BOD), total solid (TS), and suspended solids (SS) [1]. This chapter aims to introduce the available technologies for secondary wastewater treatment that are widely investigated to prevent and control pollution from the food industry. In this respect, the features of the aerobic and anaerobic biological treatment technologies are summarized. Then, an overview of the uncertainty management in biological treatment plants is provided.
Due to the nature of the food industry, the preparatory and operational processes of the raw animals, vegetables, and fruits into edible products do not include the application of chemicals. Subsequently, the organic maters in most of the cannery wastewater effluents are best treated using biological treatment, where these matters are rarely present toxicant or inhibitory compounds in their composition. Yet in some operations, e.g. sterilizing and cleaning the equipment, chemicals are used. In particular, disinfectants and caustic soda are used at the end of the processed batch. These effluents could be characterized as short-time concentrated discharges. They may cause shock loads in the wastewater treatment plants that are not designed to deal with these effluents. In this case, the use of equalization unit can achieve acceptable flow equalization and pH adjustment and dilute the high concentration to a nominal concentration that allows safe operation for the biological treatment unit [3].
Aerobic wastewater treatment processes could be applied using several technologies, i.e. pond and lagoon-based treatments; surface and spray aeration; oxidation ditches; trickling filters; septic or aerobic tanks; activated sludge; and aerobic digestion. In this section, sequencing batch reactor (SBR), activated sludge (AS), rotating biological contactor (RBC), and aerobic lagoons (AELs) for treating food processing wastewater are discussed.
In general, SBR is a fill-and-draw activated sludge system for wastewater treatment. In that system, wastewater effluent is added to a single batch reactor, where treatment is achieved by removing undesirable components, and then, the effluent is discharged. In the same single batch reactor, equalization, aeration, and clarification are conducted.
The formation of granules in aerobic conditions has been possible and appears as a promising technique for treating high-strength or highly toxic wastewaters. It appeared that aerobic granules were successfully cultivated only in SBR. The cyclic operation of SBR consisted of influent filling, aeration, settling, and effluent removal [4].
The development of aerobic granular sludge to achieve simultaneous removal of COD, phosphorous (P), and nitrogen (N) from saline fish-canning wastewater was investigated by Campo [5]. In that work, a 1.6-L SBR with a hydraulic retention time (HRT) of 0.25 d and a volumetric exchange ratio (VER) of 50% was used. The wastewater fed to the SBR was collected from a fish-canning factory located in the south of Galicia (Spain). The SBR was operated in 3-hour cycles comprising 60-min anaerobic feeding, 112-min aeration, 7–1-min settling, and 1–7-min effluent discharge. The salt concentration was approximately 10.4 ± 0.8 g NaCl/l, and the applied organic loading rate (OLR) equals 5.4 ± 1.9 kg COD/(m3d). Under these conditions, aerobic granules were detected after operational time equals 34 days. Some filamentous bacteria were detected on the surface of the aggregates. The granular biomass has a volatile suspended solids (VSS) concentration of 1.34 gVSS/l, density near 11.5 gVSS/l granule, and mean diameter of 1.35 mm. After 41 days of operation, fluffy-flocculent suspension was formed in the presence of the granules. This behavior was attributed to the salinity and the respectively high fraction of slowly biodegradable COD in the influent (35% of total COD). The study reported good removal efficiencies of soluble COD nearly equal to 80%. The phosphorus and ammonium were mainly concluded to be removed to cover the minimum metabolic demand of heterotrophic bacteria. The study indicated that the enrichment of the biomass with slow growing autotrophic and phosphorus-accumulating bacteria in a saline environment requires a longer operational time [5].
The most commonly used biological wastewater treatment technology is the activated sludge. In that technology, the activated sludge (bacterial biomass suspension) is used to degrade the organic pollutants. Over years, various activated sludge processes have been developed. Depending on the design of the AS unit, the wastewater treatment plant (WWTP) can degrade organic carbon substances and remove nutrients, i.e. N and P. In some biological wastewater treatment systems, activated sludge was attached to a surface to form a bio-film. Examples of these systems are integrated fixed-film activated sludge systems, rotating biological reactors, trickling filters, and moving bed bio-film reactors [6].
RBC process entails the contact between the wastewater and the biological medium that is used to degrade the organic contaminants. A RBC is described as a device that “consists of a series of closely spaced, parallel discs mounted on a rotating shaft which is supported just above the surface of the wastewater” [4, 7]. RBCs are used to remove biodegradable organic matter and convert ammonia-N and organic-N to nitrate-N. Operational problems caused by high organic loading rates restrict the use of RBCs for partial removal of organic matter (i.e. for “roughing” treatment). However, they can be used quite effectively for the substantial removal of organic matter. Process effluent (i.e. clarified) five-day biochemical oxygen demand (BOD5) and total suspended solids (TSS) concentrations can easily be reduced to less than 30 mg/l each, and even lower can be obtained in some instances [8].
Aerobic lagoons (AELs) are designed and operated to exclude algae. This is accomplished by two means. First, sufficient mixing is used to keep all biomass from the treatment system in suspension, thereby providing turbidity that restricts penetration of light into the water column. The mixing also has the effect of making the solid retention time (SRT) equal to the hydraulic retention time (HRT). Second, the HRT is controlled to values less than the minimum SRT for algal growth (about two days). Because algae are excluded, oxygen must be delivered by mechanical means [8].
This class of biological wastewater treatment technology utilizes microorganisms to degrade the organic pollutants in the absence of oxygen. The sludge in the anaerobic biological reactor consists of anaerobic bacteria and other microorganisms. Food processing wastewaters are particularly suitable for anaerobic treatment processes, firstly because of their high organic load and secondly because they rarely contain toxicants or inhibitory compounds [2].
The UASB process makes use of suspended growth biomass, but the gas-liquid-solids separation system is integrated with the bioreactor. The operating conditions within the reactor could be adjusted to allow the formation of large, dense, and readily settleable particles that can lead to the accumulation of very high concentrations of SS, on the order of 20 to 30 g/l as VSS. These high suspended solids concentrations allow significant separation between the SRT and HRT, and operation at relatively short HRTs, often on the order of two days or less, even when the SRT is long. The three-phase UASB reactor allows the achievement of compact and cheaper units due to its ability to separate the gas, water, and sludge mixtures under high turbulence conditions. It has multiple gas hoods for the separation of biogas and can be operated in a one-metre-height reactor that prevents the formation of floating layers [9]. Due to the extremely large gas/water interfaces, the turbulence is greatly reduced, so it is possible to operate the treatment process with relatively high loading rates of 10–15 kg/m3d [8].
UASB technology is known for its efficiency in treating wastewaters with high carbohydrate content. In this respect, the wastewater effluents from the canning industry are efficiently treated by microbes to produce a nutrient-rich starting material for anaerobic hydrogen production. This has led to the wide application of up-flow anaerobic sludge blanket (UASB) reactor for the treatment of the wastewater effluents from food processing plants [10]. These reactors are well known for their ability to withstand variations in wastewater quality and complete shutdown of the reactor in off season [11].
Anaerobic treatment of a highly alkaline fruit-cannery lye-peeling wastewater was investigated, using an up-flow anaerobic sludge blanket (UArSB) reactor. Only a short initializing period was required before COD reduction and OLR had stabilized at 85 to 90% and 2.40 kg COD/m3d, respectively. With subsequent increases in OLR to 8.1kgCOD/m3d, the COD reduction remained between 85 and 93% and biogas production peaked at 4.1 l/d (63% methane). After 111 days, the COD and reactor pH started to decrease and the gas production was reported to decrease after 102 days and continue to decrease to reach the lowest value of 0.93 l/d after 129 days. Subsequent reductions in the OLR, by reducing influent COD, had no effect on reactor stability. This reduction in the reactor performance was attributed to the inhibition of methanogenesis due to the sodium accumulation of sodium (potentially >20,000 mg/l) in the biomass [10, 12].
Anaerobic digestion (AD) is used for the stabilization of particulate organic matter. An anaerobic digester is well mixed with no liquid-solids separation. Consequently, the bioreactor can be treated as a continuous stirred tank reactor (CSTR) in which the HRT and SRT are identical. An SRT of 15 to 20 days is typically used, although SRTs as low as 10 days have been used successfully and longer SRTs are employed when greater waste stabilization is required [8].
For several cannery waste streams, the recovery of useful by-products could be achieved by anaerobic digestion. High COD content fruit and vegetable wastes (>50,000 mg/l) have been treated successfully by AD using a HRT of 10 days and a sludge age of 80 days. For elder sludges, the SS build-up within the reactor reached 30,000 mg/l, but at higher concentrations settling became a problem. Generally, successful treatment of food processing wastes could be achieved using AD with a retention time greater than 10 days and gas production of up to 0.75 m3/kg volatile solids [9, 11].
A Single reactor system for High activity Ammonium Removal Over Nitrite (SHARON) is a treatment process, which utilizes partial nitrification process for the degradation of ammonia and organic nitrogen components from wastewaters. The process results in stable nitrite formation, rather than complete oxidation to nitrate. The process relies on controlling the pH, temperature, and retention time to prevent the nitrate formation by nitrite-oxidizing bacteria, e.g. Nitrobacter. The wastewater denitrification that employs SHARON reactors can proceed with an anoxic reduction, such as Anammox. In the Anammox process (anaerobic ammonium oxidation), nitrite and ammonium are converted into nitrogen gas under anaerobic conditions without the need to add an external carbon source. In comparison with conventional N-removal processes, the SHARON process results in a reduction of required aeration energy and carbon source.
The application of the successive SHARON-Anammox processes was tested to treat the wastewater from a fish cannery plant. The effluents generated from the anaerobic digestion are characterized by their salinity up to 8000–10,000 g NaCl m−3, organic carbon content (1000–1300 g TOCm−3), and high ammonium content (700–1000 g NH+4−Nm−3). In the SHARON reactor, nearly half the ammonia is oxidized to NO−2-N via partial nitrification. Then, SHARON effluent was directed to feed the Anammox reactor. The system was reported to attain average nitrogen removal of 68%. The bacterial population distribution in the Anammox reactor, followed by FISH analysis and batch activity assays, did not change significantly despite the continuous entrance to the system of aerobic ammonium oxidizers coming from the SHARON reactor. Most of the bacteria corresponded to the Anammox population and the rest with slight variable shares to the ammonia oxidizers. Despite the continuous variations in the amounts of ammonium and nitrite in the feed wastewater, the Anammox reactor showed an unexpected robustness. Only in the period when NO−2-N concentration was higher than the NH+4-N concentration did the process destabilized and it took 14 days until the nitrogen removal percentage decreased to 34% with concentrations in the effluent of 340 g NH+4-Nm−3 and 440 g NO−2-N m−3, respectively. That study concluded that this successive application of SHARON-Anammox reactors is successful in treating high nitrogen and saline effluents with acceptable control on the ratio between the NO−2-N and NH+4-N [13].
An-MBR can be simply defined as a biological treatment process operated without oxygen and using a membrane to provide solid–liquid separation. The advantages offered by this process over conventional anaerobic systems and aerobic MBR are widely recognized [12].
Saline wastewaters are known for their negative impact on the performance of the biological treatment units. Sodium chloride is widely used, not only for cooking and to melt snow and ice, but also in a wide variety of food industries including food canning, seafood processing, milk processing, etc. In particular, the operation of the seafood processing industry leads to the generation of wastewaters with high soluble and colloidal pollutants and a high concentration of N and SS. For these effluents, the application of conventional biological treatment is not efficient. It was reported that the efficiency could be enhanced by reducing the sodium toxicity with compatible solutes that can increase the sludge activity. Moreover, the anaerobic membrane bioreactor reduces the COD concentration in the wastewater [14].
AF consists of a fixed bed biological reactor with one or more series of filtration chambers. This technology relies on the entrapment of the particles in the wastewater on the filter media and the subsequent degradation of the organic matter by the active biomass attached to the surface of the filter media [15]. As the anaerobic biomass should grow on the filter media, 6–9-month start-up period is required for AF to attain the full treatment capacity. The filter can be inoculated with anaerobic bacteria to reduce the start-up time, and the flow should be gradually increased [13, 16].
Hybrid UASB/AF systems combine aspects of the UASB process with aspects of the AF process. Influent wastewater and recirculated effluent are distributed across the bioreactor cross section and flow upward through granular and flocculent sludge blankets where anaerobic treatment occurs. The effluent from the sludge blanket zone enters a section of media similar to that used in AF systems where gas-liquid-solids separation occurs. Treated effluent then exits the media section and is collected for discharge from the bioreactor. Gas is collected under the bioreactor cover and is transported to storage and/or use. The hybrid UASB/AF process primarily uses suspended biomass, and process loadings are similar to those used with the UASB process. The solids removal system is similar to that used with the UASB process [8].
A research study on the treatment of wastewater generated from vegetable processing was conducted. In this project, an anaerobic filter, a fluidized bed reactor, and an up-flow anaerobic sludge blanket reactor associated with an anaerobic filter were designed, constructed, and tested [5]. For the anaerobic filter, the removal efficiency for COD was reported to exceed 80% for HRT of 16 h, at temperatures ranging from 20 to 31°C. The FBAR was operated at HRT of 2 h with mean COD removal efficiency of 63%. The UASB/AF achieved mean COD removal efficiency of 80% at HRT of 6 h [17].
Anoxic process is widely used in wastewater treatment. Anoxic means depletion or deficiency of oxygen. Anoxic process is a biological treatment process by which NO3-N is converted to molecular nitrogen gas in the absence of oxygen.
A system comprised of anaerobic-anoxic-aerobic reactors was tested to treat the wastewater from tuna cooker. This wastewater stream is characterized by high COD and N concentrations. The up-flow anaerobic sludge blanket reactor was used to achieve the anaerobic digestion in a two-step process. In the first, the COD concentration was varied and ORLs up to 4 g COD/(l.d) were achieved. In the second step, the 6 g COD/l and the HRT were varied between 0.5 and 0.8 day, and this step led to ORLs less than 15 g COD/(l.d). The denitrification process was carried out in an up-flow anoxic filter, and the result of the project indicated that the efficiency of this process is dependent on the supplied carbon content. For optimum carbon content, the ratio between the COD and N equalled 4 and the denitrification percentage equalled 80%. Finally, the nitrification was reported to be fixed at 100% ammonia removal regardless of the amount of carbon in the range of 0.2–0.8 g TOC/l. The variation of the recycling ratios between the denitrification and nitrification reactors in the range of 1–2.5 was found to affect the efficiency of the COD and N-removal percentage, where 90 and 60% removal for COD and N was reported at recycling ratio between 2 and 2.5 [15].
There are several types of uncertainties that should be addressed during the design of a wastewater treatment plant, e.g. the variation in strength and quantity of wastewater entering into the plant, the diversity, and the dynamics of the microbial community. An uncertainty analysis for a pre-denitrification plant that uses an activated sludge unit was performed [18]. The unit consists of five compartments: the first two are anoxic and the last three are aerobic. Three scenarios were considered in that study that cover the uncertainty due to stoichiometric, bio-kinetic and influent parameters; uncertainty due to hydraulic behavior of the plant and mass transfer parameters; and uncertainty due to the combination of both scenarios. The study concluded that parameters related to the first and second scenarios introduce significant uncertainties in the plant performance measures. In addition, it was stated that the applied uncertainty farming technique largely affects the uncertainty estimates.
The Monte Carlo simulation was intensively used to simulate the design and upgrade of wastewater treatment plants under uncertainty in balancing effluent costs, violating effluent quality standards, predicting the disinfection performance, generating different influent compositions for posterior process performance evaluation or as a pragmatic procedure to automate the calibration of ASM models, and considering the impact of the input parameter uncertainty on the multi-criteria evaluation of control strategies at wastewater plant [19, 20, 21, 22].
Due to the complexity and non-linearity of wastewater treatment plant operations, mathematical models are generally not sufficient to predict the performance of WWTPs. Therefore, AI models have been proposed as an alternative model to linear methods. The methods for minimizing the effect of uncertainty in wastewater characteristics and wastewater flow on wastewater treatment reported in the literature have included support vector machine (SVM) and artificial neural network (ANN) [23]. An optimization model to control uncertainty in operation of wastewater treatment from the shale gas production has been reported in the literature [24]. In addition, genetic algorithms have been developed to model and optimize a biological wastewater treatment plant [25].
Information regarding uncertainty in the wastewater treatment plants in treating cannery wastewater is lacking in the literature. However, the principles governing uncertainty in wastewater treatment plants can be applied to control uncertainty in cannery wastewater treatment.
The following conclusions can be reached based on the review of literature in cannery wastewater treatment:
The wastewater that is generated in food canning industries contains high quantities of organic material, a high level of biodegradables and variable pH levels.
The food processing industry requires a large amount of potable water for a variety of non-consumption usages, such as for initial cleaning of raw material, fluming, blanching, pasteurizing, cleaning of processing equipment, and cooling of finished product.
The nature of the organic matter of cannery industry wastewater makes it suitable for biological treatment.
Flow equalization and influent pH control normally have enough diluting and neutralizing effect to permit the use of biological processes for cannery wastewater treatment.
Various treatment processes using aerobic and anaerobic treatment can be applied for the treatment of cannery wastewater, depending upon wastewater strength.
Information regarding uncertainty in wastewater treatment plants in treating cannery wastewater is lacking in the literature. However, the principles governing uncertainty in wastewater treatment plants can be applied to control uncertainty in cannery wastewater treatment.
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Gomes",authors:[{id:"56285",title:"Prof.",name:"Ana Colette",middleName:null,surname:"Maurício",slug:"ana-colette-mauricio",fullName:"Ana Colette Maurício"},{id:"161695",title:"Prof.",name:"José",middleName:null,surname:"Domingos",slug:"jose-domingos",fullName:"José Domingos"},{id:"215518",title:"MSc.",name:"Daniel",middleName:null,surname:"Santos",slug:"daniel-santos",fullName:"Daniel Santos"},{id:"215519",title:"Prof.",name:"Vitor",middleName:null,surname:"Sencadas",slug:"vitor-sencadas",fullName:"Vitor Sencadas"},{id:"215799",title:"Dr.",name:"Pedro",middleName:null,surname:"Gomes",slug:"pedro-gomes",fullName:"Pedro Gomes"},{id:"215800",title:"Dr.",name:"Maria Helena",middleName:null,surname:"Fernandes",slug:"maria-helena-fernandes",fullName:"Maria Helena Fernandes"}]},{id:"23633",title:"The Use of Biomaterials to Treat Abdominal Hernias",slug:"the-use-of-biomaterials-to-treat-abdominal-hernias",totalDownloads:8392,totalCrossrefCites:6,totalDimensionsCites:11,abstract:null,book:{id:"1487",slug:"biomaterials-applications-for-nanomedicine",title:"Biomaterials",fullTitle:"Biomaterials Applications for Nanomedicine"},signatures:"Luciano Zogbi",authors:[{id:"56634",title:"Dr.",name:"Luciano",middleName:null,surname:"Zogbi",slug:"luciano-zogbi",fullName:"Luciano Zogbi"}]},{id:"65140",title:"Microbial Bioremediation and Different Bioreactors Designs Applied",slug:"microbial-bioremediation-and-different-bioreactors-designs-applied",totalDownloads:1886,totalCrossrefCites:9,totalDimensionsCites:21,abstract:"Microbial remediation of pollutants involves the use of microorganisms to degrade pollutants either completely to water and carbon dioxide (for organic pollutants) or into less toxic forms. In the case of nonbiodegradable inorganic compounds, bioremediation takes the form of bioaccumulation or conversion of one toxic species to a less toxic form for example Cr(VI) is converted to less toxic (III). Bioremediation is considered an environmentally friendly way for pollution clean-up. Microbial clean up can be applied in situ (in place of contamination) or ex situ (off the site of contamination). In situ remediation in the natural environment is deemed slow and often times difficult to control and optimize the different parameters affecting the bioremediation. To this end, use of engineered bioreactors is preferred. Engineered bioreactors providing for optimum conditions for microbial growth and biodegradation have been developed for use in bioremediation processes to achieve the different desired remediation goals. Bioreactors in use range in mode of operation from batch, continuous, and fed batch bioreactors and are designed to optimize microbial processes in relationship to contaminated media and nature of pollutant. Designed bioreactors for bioremediation range from packed, stirred tanks, airlift, slurry phase, and partitioning phase reactors amongst others.",book:{id:"7727",slug:"biotechnology-and-bioengineering",title:"Biotechnology and Bioengineering",fullTitle:"Biotechnology and Bioengineering"},signatures:"Memory Tekere",authors:[{id:"231753",title:"Prof.",name:"Memory",middleName:null,surname:"Tekere",slug:"memory-tekere",fullName:"Memory Tekere"}]},{id:"67432",title:"Microencapsulation and Its Uses in Food Science and Technology: A Review",slug:"microencapsulation-and-its-uses-in-food-science-and-technology-a-review",totalDownloads:1889,totalCrossrefCites:7,totalDimensionsCites:13,abstract:"Microencapsulation is a group of technologies aiming to produce small particles called microcapsules that can be released at a specific speed under certain conditions. Microencapsulation technology is used in the pharmaceutical, agrochemical, and food industries; however, microcapsule production is most challenging for applications in the food industry owing to the high costs of the technique, which may make the final product too expensive. Common methods for microencapsulation include spray-drying and coacervation, and different wall materials and filling materials can be used for both techniques. In this review, we summarize current methodologies used for microencapsulation, with a focus on applications in the food industry.",book:{id:"6995",slug:"microencapsulation-processes-technologies-and-industrial-applications",title:"Microencapsulation",fullTitle:"Microencapsulation - Processes, Technologies and Industrial Applications"},signatures:"Pedro Henrique Rodrigues do Amaral, Patrícia Lopes Andrade and Leilane Costa de Conto",authors:[{id:"268220",title:"Dr.",name:"Leilane Costa De",middleName:null,surname:"Conto",slug:"leilane-costa-de-conto",fullName:"Leilane Costa De Conto"},{id:"274532",title:"Mr.",name:"Pedro Henrique Rodrigues Do",middleName:null,surname:"Amaral",slug:"pedro-henrique-rodrigues-do-amaral",fullName:"Pedro Henrique Rodrigues Do Amaral"},{id:"274534",title:"Dr.",name:"Patrícia Lopes",middleName:null,surname:"Andrade",slug:"patricia-lopes-andrade",fullName:"Patrícia Lopes Andrade"}]},{id:"64746",title:"HyStem®: A Unique Clinical Grade Hydrogel for Present and Future Medical Applications",slug:"hystem-a-unique-clinical-grade-hydrogel-for-present-and-future-medical-applications",totalDownloads:4431,totalCrossrefCites:2,totalDimensionsCites:3,abstract:"Medicine needs targeted, minimally-invasive delivery of protein-based and cell-based therapeutics to increase efficacy and reduce occurrence and severity of side effects. Local delivery requires a matrix to sequester and protect the medicine until its effect can be realized. The problem is, unlike stable small molecule drugs, proteins and cells cannot be co-packaged with a matrix in a prefilled syringe—they must be mixed with their matrix at the point of care. HyStem hydrogels fix this problem: They are arguably the first commercially available, GMP-qualified biodegradable hydrogels both with the ability to formulate with either proteins or cells in the hospital/surgical suite and with a history of safe use in humans. HyStem is designed to be protein, cell-friendly and in situ crosslinkable, permitting homogeneous mixing of therapeutics. One HyStem formulation is 510(k) cleared and another the subject of two European clinical trials. Key applications include localized delivery of therapeutic growth factors, antibodies, and cells. In the future, we envision HyStem’s flexibility and clinical use history forming the basis for a new generation of therapeutics. Two examples described here include HyStem’s use for patient-derived organoid culture to develop new drugs as well as for bioprinting to manufacture new organs.",book:{id:"8353",slug:"hydrogels-smart-materials-for-biomedical-applications",title:"Hydrogels",fullTitle:"Hydrogels - Smart Materials for Biomedical Applications"},signatures:"Thomas I. Zarembinski and Aleksander Skardal",authors:[{id:"262573",title:"Dr.",name:"Thomas",middleName:null,surname:"Zarembinski",slug:"thomas-zarembinski",fullName:"Thomas Zarembinski"},{id:"270426",title:"Dr.",name:"Aleksander",middleName:null,surname:"Skardal",slug:"aleksander-skardal",fullName:"Aleksander Skardal"}]}],onlineFirstChaptersFilter:{topicId:"154",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:32,numberOfPublishedChapters:320,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:133,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:5,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:16,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"7",title:"Biomedical Engineering",doi:"10.5772/intechopen.71985",issn:"2631-5343",scope:"Biomedical Engineering is one of the fastest-growing interdisciplinary branches of science and industry. 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Dr. Koprowski has authored more than a hundred research papers with dozens in impact factor (IF) journals and has authored or co-authored six books. Additionally, he is the author of several national and international patents in the field of biomedical devices and imaging. Since 2011, he has been a reviewer of grants and projects (including EU projects) in biomedical engineering.",institutionString:null,institution:{name:"University of Silesia",institutionURL:null,country:{name:"Poland"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:5,paginationItems:[{id:"91",title:"Sustainable Economy and Fair Society",coverUrl:"https://cdn.intechopen.com/series_topics/covers/91.jpg",isOpenForSubmission:!0,annualVolume:11975,editor:{id:"181603",title:"Dr.",name:"Antonella",middleName:null,surname:"Petrillo",slug:"antonella-petrillo",fullName:"Antonella Petrillo",profilePictureURL:"https://mts.intechopen.com/storage/users/181603/images/system/181603.jpg",biography:"Antonella Petrillo is a Professor at the Department of Engineering of the University of Naples “Parthenope”, Italy. She received her Ph.D. in Mechanical Engineering from the University of Cassino. Her research interests include multi-criteria decision analysis, industrial plant, logistics, manufacturing and safety. She serves as an Associate Editor for the International Journal of the Analytic Hierarchy Process. She is a member of AHP Academy and a member of several editorial boards. 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Her focus is on quality, innovation, leadership, and personalised learning. She works primarily at the strategic and policy levels, both nationally and internationally, and with key international organisations. She is committed to promoting and improving OFDL in the context of SDG4 and the future of education. Ossiannilsson has more than 20 years of experience in her current field, but more than 40 years in the education sector. She works as a reviewer and expert for the European Commission and collaborates with the Joint Research Centre for Quality in Open Education. Ossiannilsson also collaborates with ITCILO and ICoBC (International Council on Badges and Credentials). She is a member of the ICDE Board of Directors and has previously served on the boards of EDEN and EUCEN. Ossiannilsson is a quality expert and reviewer for ICDE, EDEN and the EADTU. She chairs the ICDE OER Advocacy Committee and is a member of the ICDE Quality Network. 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He collaborates with the Environmental Resources Analysis Research Group (ARAM), University of Extremadura (UEx), Spain; VALORIZA - Research Center for the Enhancement of Endogenous Resources, Polytechnic Institute of Portalegre (IPP), Portugal; Centre for Tourism Research, Development and Innovation (CITUR), Madeira, Portugal; and AQUAGEO Research Group, University of Campinas (UNICAMP), Brazil.",institutionString:"University of Johannesburg, South Africa and WSB University, Poland",institution:{name:"University of Johannesburg",institutionURL:null,country:{name:"South Africa"}}},editorThree:null}]},overviewPageOFChapters:{paginationCount:15,paginationItems:[{id:"82457",title:"Canine Hearing Management",doi:"10.5772/intechopen.105515",signatures:"Peter M. 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She obtained her Ph.D. in Veterinary Sciences from the University of Trás-os-Montes e Alto Douro, Portugal. After almost 32 years of teaching at the University of Trás-os-Montes and Alto Douro, she recently moved to the University of Évora, Department of Veterinary Medicine, where she teaches in the field of Animal Reproduction and Clinics. Her primary research areas include the molecular markers of the endometrial cycle and the embryo–maternal interaction, including oxidative stress and the reproductive physiology and disorders of sexual development, besides the molecular determinants of male and female fertility. She often supervises students preparing their master's or doctoral theses. 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Several international research projects has been performed with European partners from France, Netherlands, Norway and the UK. He is currently Professor of Communications Systems at the Harz University of Applied Sciences, Germany.\n\nPublications and Publishing\nHe has edited one book, a special interest book about ‘Optoelectronic Packaging’ (VDE, Berlin, Germany), and has published over 100 papers and is owner of several international patents for WDM over POF key elements.\n\nKey Research and Consulting Interests\nUlrich’s research activity has always been related to Spectroscopy and Optical Communications Technology. Specific current interests include the validation of complex instruments, and the application of VR technology to the development and testing of measurement systems. He has been reviewer for several publications of the Optical Society of America\\'s including Photonics Technology Letters and Applied Optics.\n\nPersonal Interests\nThese include motor cycling in a very relaxed manner and performing martial arts.",institutionString:null,institution:{name:"Charité",country:{name:"Germany"}}},{id:"341622",title:"Ph.D.",name:"Eduardo",middleName:null,surname:"Rojas Alvarez",slug:"eduardo-rojas-alvarez",fullName:"Eduardo Rojas Alvarez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/341622/images/15892_n.jpg",biography:null,institutionString:null,institution:{name:"University of Cuenca",country:{name:"Ecuador"}}},{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/215610/images/system/215610.jpeg",biography:"Muhammad Sarfraz is a professor in the Department of Information Science, Kuwait University. His research interests include computer graphics, computer vision, image processing, machine learning, pattern recognition, soft computing, data science, intelligent systems, information technology, and information systems. Prof. Sarfraz has been a keynote/invited speaker on various platforms around the globe. He has advised various students for their MSc and Ph.D. theses. He has published more than 400 publications as books, journal articles, and conference papers. He is a member of various professional societies and a chair and member of the International Advisory Committees and Organizing Committees of various international conferences. Prof. Sarfraz is also an editor-in-chief and editor of various international journals.",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"32650",title:"Prof.",name:"Lukas",middleName:"Willem",surname:"Snyman",slug:"lukas-snyman",fullName:"Lukas Snyman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/32650/images/4136_n.jpg",biography:"Lukas Willem Snyman received his basic education at primary and high schools in South Africa, Eastern Cape. He enrolled at today's Nelson Metropolitan University and graduated from this university with a BSc in Physics and Mathematics, B.Sc Honors in Physics, MSc in Semiconductor Physics, and a Ph.D. in Semiconductor Physics in 1987. After his studies, he chose an academic career and devoted his energy to the teaching of physics to first, second, and third-year students. After positions as a lecturer at the University of Port Elizabeth, he accepted a position as Associate Professor at the University of Pretoria, South Africa.\r\n\r\nIn 1992, he motivates the concept of 'television and computer-based education” as means to reach large student numbers with only the best of teaching expertise and publishes an article on the concept in the SA Journal of Higher Education of 1993 (and later in 2003). The University of Pretoria subsequently approved a series of test projects on the concept with outreach to Mamelodi and Eerste Rust in 1993. In 1994, the University established a 'Unit for Telematic Education ' as a support section for multiple faculties at the University of Pretoria. In subsequent years, the concept of 'telematic education” subsequently becomes well established in academic circles in South Africa, grew in popularity, and is adopted by many universities and colleges throughout South Africa as a medium of enhancing education and training, as a method to reaching out to far out communities, and as a means to enhance study from the home environment.\r\n\r\nProfessor Snyman in subsequent years pursued research in semiconductor physics, semiconductor devices, microelectronics, and optoelectronics.\r\n\r\nIn 2000 he joined the TUT as a full professor. Here served for a period as head of the Department of Electronic Engineering. Here he makes contributions to solar energy development, microwave and optoelectronic device development, silicon photonics, as well as contributions to new mobile telecommunication systems and network planning in SA.\r\n\r\nCurrently, he teaches electronics and telecommunications at the TUT to audiences ranging from first-year students to Ph.D. level.\r\n\r\nFor his research in the field of 'Silicon Photonics” since 1990, he has published (as author and co-author) about thirty internationally reviewed articles in scientific journals, contributed to more than forty international conferences, about 25 South African provisional patents (as inventor and co-inventor), 8 PCT international patent applications until now. Of these, two USA patents applications, two European Patents, two Korean patents, and ten SA patents have been granted. A further 4 USA patents, 5 European patents, 3 Korean patents, 3 Chinese patents, and 3 Japanese patents are currently under consideration.\r\n\r\nRecently he has also published an extensive scholarly chapter in an internet open access book on 'Integrating Microphotonic Systems and MOEMS into standard Silicon CMOS Integrated circuitry”.\r\n\r\nFurthermore, Professor Snyman recently steered a new initiative at the TUT by introducing a 'Laboratory for Innovative Electronic Systems ' at the Department of Electrical Engineering. The model of this laboratory or center is to primarily combine outputs as achieved by high-level research with lower-level system development and entrepreneurship in a technical university environment. Students are allocated to projects at different levels with PhDs and Master students allocated to the generation of new knowledge and new technologies, while students at the diploma and Baccalaureus level are allocated to electronic systems development with a direct and a near application for application in industry or the commercial and public sectors in South Africa.\r\n\r\nProfessor Snyman received the WIRSAM Award of 1983 and the WIRSAM Award in 1985 in South Africa for best research papers by a young scientist at two international conferences on electron microscopy in South Africa. He subsequently received the SA Microelectronics Award for the best dissertation emanating from studies executed at a South African university in the field of Physics and Microelectronics in South Africa in 1987. In October of 2011, Professor Snyman received the prestigious Institutional Award for 'Innovator of the Year” for 2010 at the Tshwane University of Technology, South Africa. This award was based on the number of patents recognized and granted by local and international institutions as well as for his contributions concerning innovation at the TUT.",institutionString:null,institution:{name:"University of South Africa",country:{name:"South Africa"}}},{id:"317279",title:"Mr.",name:"Ali",middleName:"Usama",surname:"Syed",slug:"ali-syed",fullName:"Ali Syed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/317279/images/16024_n.png",biography:"A creative, talented, and innovative young professional who is dedicated, well organized, and capable research fellow with two years of experience in graduate-level research, published in engineering journals and book, with related expertise in Bio-robotics, equally passionate about the aesthetics of the mechanical and electronic system, obtained expertise in the use of MS Office, MATLAB, SolidWorks, LabVIEW, Proteus, Fusion 360, having a grasp on python, C++ and assembly language, possess proven ability in acquiring research grants, previous appointments with social and educational societies with experience in administration, current affiliations with IEEE and Web of Science, a confident presenter at conferences and teacher in classrooms, able to explain complex information to audiences of all levels.",institutionString:null,institution:{name:"Air University",country:{name:"Pakistan"}}},{id:"75526",title:"Ph.D.",name:"Zihni Onur",middleName:null,surname:"Uygun",slug:"zihni-onur-uygun",fullName:"Zihni Onur Uygun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/75526/images/12_n.jpg",biography:"My undergraduate education and my Master of Science educations at Ege University and at Çanakkale Onsekiz Mart University have given me a firm foundation in Biochemistry, Analytical Chemistry, Biosensors, Bioelectronics, Physical Chemistry and Medicine. After obtaining my degree as a MSc in analytical chemistry, I started working as a research assistant in Ege University Medical Faculty in 2014. In parallel, I enrolled to the MSc program at the Department of Medical Biochemistry at Ege University to gain deeper knowledge on medical and biochemical sciences as well as clinical chemistry in 2014. In my PhD I deeply researched on biosensors and bioelectronics and finished in 2020. Now I have eleven SCI-Expanded Index published papers, 6 international book chapters, referee assignments for different SCIE journals, one international patent pending, several international awards, projects and bursaries. In parallel to my research assistant position at Ege University Medical Faculty, Department of Medical Biochemistry, in April 2016, I also founded a Start-Up Company (Denosens Biotechnology LTD) by the support of The Scientific and Technological Research Council of Turkey. Currently, I am also working as a CEO in Denosens Biotechnology. The main purposes of the company, which carries out R&D as a research center, are to develop new generation biosensors and sensors for both point-of-care diagnostics; such as glucose, lactate, cholesterol and cancer biomarker detections. My specific experimental and instrumental skills are Biochemistry, Biosensor, Analytical Chemistry, Electrochemistry, Mobile phone based point-of-care diagnostic device, POCTs and Patient interface designs, HPLC, Tandem Mass Spectrometry, Spectrophotometry, ELISA.",institutionString:null,institution:{name:"Ege University",country:{name:"Turkey"}}},{id:"267434",title:"Dr.",name:"Rohit",middleName:null,surname:"Raja",slug:"rohit-raja",fullName:"Rohit Raja",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/267434/images/system/267434.jpg",biography:"Dr. Rohit Raja received Ph.D. in Computer Science and Engineering from Dr. CVRAMAN University in 2016. His main research interest includes Face recognition and Identification, Digital Image Processing, Signal Processing, and Networking. Presently he is working as Associate Professor in IT Department, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur (CG), India. He has authored several Journal and Conference Papers. He has good Academics & Research experience in various areas of CSE and IT. He has filed and successfully published 27 Patents. He has received many time invitations to be a Guest at IEEE Conferences. He has published 100 research papers in various International/National Journals (including IEEE, Springer, etc.) and Proceedings of the reputed International/ National Conferences (including Springer and IEEE). He has been nominated to the board of editors/reviewers of many peer-reviewed and refereed Journals (including IEEE, Springer).",institutionString:"Guru Ghasidas Vishwavidyalaya",institution:{name:"Guru Ghasidas Vishwavidyalaya",country:{name:"India"}}},{id:"246502",title:"Dr.",name:"Jaya T.",middleName:"T",surname:"Varkey",slug:"jaya-t.-varkey",fullName:"Jaya T. Varkey",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246502/images/11160_n.jpg",biography:"Jaya T. Varkey, PhD, graduated with a degree in Chemistry from Cochin University of Science and Technology, Kerala, India. She obtained a PhD in Chemistry from the School of Chemical Sciences, Mahatma Gandhi University, Kerala, India, and completed a post-doctoral fellowship at the University of Minnesota, USA. She is a research guide at Mahatma Gandhi University and Associate Professor in Chemistry, St. Teresa’s College, Kochi, Kerala, India.\nDr. Varkey received a National Young Scientist award from the Indian Science Congress (1995), a UGC Research award (2016–2018), an Indian National Science Academy (INSA) Visiting Scientist award (2018–2019), and a Best Innovative Faculty award from the All India Association for Christian Higher Education (AIACHE) (2019). She Hashas received the Sr. Mary Cecil prize for best research paper three times. She was also awarded a start-up to develop a tea bag water filter. \nDr. Varkey has published two international books and twenty-seven international journal publications. She is an editorial board member for five international journals.",institutionString:"St. Teresa’s College",institution:null},{id:"250668",title:"Dr.",name:"Ali",middleName:null,surname:"Nabipour Chakoli",slug:"ali-nabipour-chakoli",fullName:"Ali Nabipour Chakoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/250668/images/system/250668.jpg",biography:"Academic Qualification:\r\n•\tPhD in Materials Physics and Chemistry, From: Sep. 2006, to: Sep. 2010, School of Materials Science and Engineering, Harbin Institute of Technology, Thesis: Structure and Shape Memory Effect of Functionalized MWCNTs/poly (L-lactide-co-ε-caprolactone) Nanocomposites. Supervisor: Prof. Wei Cai,\r\n•\tM.Sc in Applied Physics, From: 1996, to: 1998, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Determination of Boron in Micro alloy Steels with solid state nuclear track detectors by neutron induced auto radiography, Supervisors: Dr. M. Hosseini Ashrafi and Dr. A. Hosseini.\r\n•\tB.Sc. in Applied Physics, From: 1991, to: 1996, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Design of shielding for Am-Be neutron sources for In Vivo neutron activation analysis, Supervisor: Dr. M. Hosseini Ashrafi.\r\n\r\nResearch Experiences:\r\n1.\tNanomaterials, Carbon Nanotubes, Graphene: Synthesis, Functionalization and Characterization,\r\n2.\tMWCNTs/Polymer Composites: Fabrication and Characterization, \r\n3.\tShape Memory Polymers, Biodegradable Polymers, ORC, Collagen,\r\n4.\tMaterials Analysis and Characterizations: TEM, SEM, XPS, FT-IR, Raman, DSC, DMA, TGA, XRD, GPC, Fluoroscopy, \r\n5.\tInteraction of Radiation with Mater, Nuclear Safety and Security, NDT(RT),\r\n6.\tRadiation Detectors, Calibration (SSDL),\r\n7.\tCompleted IAEA e-learning Courses:\r\nNuclear Security (15 Modules),\r\nNuclear Safety:\r\nTSA 2: Regulatory Protection in Occupational Exposure,\r\nTips & Tricks: Radiation Protection in Radiography,\r\nSafety and Quality in Radiotherapy,\r\nCourse on Sealed Radioactive Sources,\r\nCourse on Fundamentals of Environmental Remediation,\r\nCourse on Planning for Environmental Remediation,\r\nKnowledge Management Orientation Course,\r\nFood Irradiation - Technology, Applications and Good Practices,\r\nEmployment:\r\nFrom 2010 to now: Academic staff, Nuclear Science and Technology Research Institute, Kargar Shomali, Tehran, Iran, P.O. Box: 14395-836.\r\nFrom 1997 to 2006: Expert of Materials Analysis and Characterization. Research Center of Agriculture and Medicine. Rajaeeshahr, Karaj, Iran, P. O. Box: 31585-498.",institutionString:"Atomic Energy Organization of Iran",institution:{name:"Atomic Energy Organization of Iran",country:{name:"Iran"}}},{id:"248279",title:"Dr.",name:"Monika",middleName:"Elzbieta",surname:"Machoy",slug:"monika-machoy",fullName:"Monika Machoy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248279/images/system/248279.jpeg",biography:"Monika Elżbieta Machoy, MD, graduated with distinction from the Faculty of Medicine and Dentistry at the Pomeranian Medical University in 2009, defended her PhD thesis with summa cum laude in 2016 and is currently employed as a researcher at the Department of Orthodontics of the Pomeranian Medical University. She expanded her professional knowledge during a one-year scholarship program at the Ernst Moritz Arndt University in Greifswald, Germany and during a three-year internship at the Technical University in Dresden, Germany. She has been a speaker at numerous orthodontic conferences, among others, American Association of Orthodontics, European Orthodontic Symposium and numerous conferences of the Polish Orthodontic Society. She conducts research focusing on the effect of orthodontic treatment on dental and periodontal tissues and the causes of pain in orthodontic patients.",institutionString:"Pomeranian Medical University",institution:{name:"Pomeranian Medical University",country:{name:"Poland"}}},{id:"252743",title:"Prof.",name:"Aswini",middleName:"Kumar",surname:"Kar",slug:"aswini-kar",fullName:"Aswini Kar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252743/images/10381_n.jpg",biography:"uploaded in cv",institutionString:null,institution:{name:"KIIT University",country:{name:"India"}}},{id:"204256",title:"Dr.",name:"Anil",middleName:"Kumar",surname:"Kumar Sahu",slug:"anil-kumar-sahu",fullName:"Anil Kumar Sahu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204256/images/14201_n.jpg",biography:"I have nearly 11 years of research and teaching experience. I have done my master degree from University Institute of Pharmacy, Pt. Ravi Shankar Shukla University, Raipur, Chhattisgarh India. I have published 16 review and research articles in international and national journals and published 4 chapters in IntechOpen, the world’s leading publisher of Open access books. I have presented many papers at national and international conferences. I have received research award from Indian Drug Manufacturers Association in year 2015. My research interest extends from novel lymphatic drug delivery systems, oral delivery system for herbal bioactive to formulation optimization.",institutionString:null,institution:{name:"Chhattisgarh Swami Vivekanand Technical University",country:{name:"India"}}},{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",biography:"An assistant professor at Department of Biomedical Computer Systems, at Institute of Computer Science, Silesian University in Katowice. Scientific interests: computer analysis and processing of images, biomedical images, databases and programming languages. He is an author and co-author of scientific publications covering analysis and processing of biomedical images and development of database systems.",institutionString:"University of Silesia",institution:null},{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",biography:"Dr. Hadi Mohammadi is a biomedical engineer with hands-on experience in the design and development of many engineering structures and medical devices through various projects that he has been involved in over the past twenty years. Dr. Mohammadi received his BSc. and MSc. degrees in Mechanical Engineering from Sharif University of Technology, Tehran, Iran, and his PhD. degree in Biomedical Engineering (biomaterials) from the University of Western Ontario. He was a postdoctoral trainee for almost four years at University of Calgary and Harvard Medical School. He is an industry innovator having created the technology to produce lifelike synthetic platforms that can be used for the simulation of almost all cardiovascular reconstructive surgeries. He’s been heavily involved in the design and development of cardiovascular devices and technology for the past 10 years. He is currently an Assistant Professor with the University of British Colombia, Canada.",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",country:{name:"Canada"}}},{id:"254463",title:"Prof.",name:"Haisheng",middleName:null,surname:"Yang",slug:"haisheng-yang",fullName:"Haisheng Yang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/254463/images/system/254463.jpeg",biography:"Haisheng Yang, Ph.D., Professor and Director of the Department of Biomedical Engineering, College of Life Science and Bioengineering, Beijing University of Technology. He received his Ph.D. degree in Mechanics/Biomechanics from Harbin Institute of Technology (jointly with University of California, Berkeley). Afterwards, he worked as a Postdoctoral Research Associate in the Purdue Musculoskeletal Biology and Mechanics Lab at the Department of Basic Medical Sciences, Purdue University, USA. He also conducted research in the Research Centre of Shriners Hospitals for Children-Canada at McGill University, Canada. Dr. Yang has over 10 years research experience in orthopaedic biomechanics and mechanobiology of bone adaptation and regeneration. He earned an award from Beijing Overseas Talents Aggregation program in 2017 and serves as Beijing Distinguished Professor.",institutionString:null,institution:{name:"Beijing University of Technology",country:{name:"China"}}},{id:"89721",title:"Dr.",name:"Mehmet",middleName:"Cuneyt",surname:"Ozmen",slug:"mehmet-ozmen",fullName:"Mehmet Ozmen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/89721/images/7289_n.jpg",biography:null,institutionString:null,institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"242893",title:"Ph.D. Student",name:"Joaquim",middleName:null,surname:"De Moura",slug:"joaquim-de-moura",fullName:"Joaquim De Moura",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/242893/images/7133_n.jpg",biography:"Joaquim de Moura received his degree in Computer Engineering in 2014 from the University of A Coruña (Spain). In 2016, he received his M.Sc degree in Computer Engineering from the same university. He is currently pursuing his Ph.D degree in Computer Science in a collaborative project between ophthalmology centers in Galicia and the University of A Coruña. His research interests include computer vision, machine learning algorithms and analysis and medical imaging processing of various kinds.",institutionString:null,institution:{name:"University of A Coruña",country:{name:"Spain"}}},{id:"294334",title:"B.Sc.",name:"Marc",middleName:null,surname:"Bruggeman",slug:"marc-bruggeman",fullName:"Marc Bruggeman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/294334/images/8242_n.jpg",biography:"Chemical engineer graduate, with a passion for material science and specific interest in polymers - their near infinite applications intrigue me. \n\nI plan to continue my scientific career in the field of polymeric biomaterials as I am fascinated by intelligent, bioactive and biomimetic materials for use in both consumer and medical applications.",institutionString:null,institution:null},{id:"255757",title:"Dr.",name:"Igor",middleName:"Victorovich",surname:"Lakhno",slug:"igor-lakhno",fullName:"Igor Lakhno",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255757/images/system/255757.jpg",biography:"Igor Victorovich Lakhno was born in 1971 in Kharkiv (Ukraine). \nMD – 1994, Kharkiv National Medical Univesity.\nOb&Gyn; – 1997, master courses in Kharkiv Medical Academy of Postgraduate Education.\nPh.D. – 1999, Kharkiv National Medical Univesity.\nDSC – 2019, PL Shupik National Academy of Postgraduate Education \nProfessor – 2021, Department of Obstetrics and Gynecology of VN Karazin Kharkiv National University\nHead of Department – 2021, Department of Perinatology, Obstetrics and gynecology of Kharkiv Medical Academy of Postgraduate Education\nIgor Lakhno has been graduated from international training courses on reproductive medicine and family planning held at Debrecen University (Hungary) in 1997. Since 1998 Lakhno Igor has worked as an associate professor in the department of obstetrics and gynecology of VN Karazin National University and an associate professor of the perinatology, obstetrics, and gynecology department of Kharkiv Medical Academy of Postgraduate Education. Since June 2019 he’s been a professor in the department of obstetrics and gynecology of VN Karazin National University and a professor of the perinatology, obstetrics, and gynecology department. He’s affiliated with Kharkiv Medical Academy of Postgraduate Education as a Head of Department from November 2021. Igor Lakhno has participated in several international projects on fetal non-invasive electrocardiography (with Dr. J. A. Behar (Technion), Prof. D. Hoyer (Jena University), and José Alejandro Díaz Méndez (National Institute of Astrophysics, Optics, and Electronics, Mexico). He’s an author of about 200 printed works and there are 31 of them in Scopus or Web of Science databases. Igor Lakhno is a member of the Editorial Board of Reproductive Health of Woman, Emergency Medicine, and Technology Transfer Innovative Solutions in Medicine (Estonia). He is a medical Editor of “Z turbotoyu pro zhinku”. Igor Lakhno is a reviewer of the Journal of Obstetrics and Gynaecology (Taylor and Francis), British Journal of Obstetrics and Gynecology (Wiley), Informatics in Medicine Unlocked (Elsevier), The Journal of Obstetrics and Gynecology Research (Wiley), Endocrine, Metabolic & Immune Disorders-Drug Targets (Bentham Open), The Open Biomedical Engineering Journal (Bentham Open), etc. He’s defended a dissertation for a DSc degree “Pre-eclampsia: prediction, prevention, and treatment”. Three years ago Igor Lakhno has participated in a training course on innovative technologies in medical education at Lublin Medical University (Poland). Lakhno Igor has participated as a speaker in several international conferences and congresses (International Conference on Biological Oscillations April 10th-14th 2016, Lancaster, UK, The 9th conference of the European Study Group on Cardiovascular Oscillations). His main scientific interests: are obstetrics, women’s health, fetal medicine, and cardiovascular medicine. \nIgor Lakhno is a consultant at Kharkiv municipal perinatal center. He’s graduated from training courses on endoscopy in gynecology. He has 28 years of practical experience in the field.",institutionString:null,institution:null},{id:"244950",title:"Dr.",name:"Salvatore",middleName:null,surname:"Di Lauro",slug:"salvatore-di-lauro",fullName:"Salvatore Di Lauro",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0030O00002bSF1HQAW/ProfilePicture%202021-12-20%2014%3A54%3A14.482",biography:"Name:\n\tSALVATORE DI LAURO\nAddress:\n\tHospital Clínico Universitario Valladolid\nAvda Ramón y Cajal 3\n47005, Valladolid\nSpain\nPhone number: \nFax\nE-mail:\n\t+34 983420000 ext 292\n+34 983420084\nsadilauro@live.it\nDate and place of Birth:\nID Number\nMedical Licence \nLanguages\t09-05-1985. Villaricca (Italy)\n\nY1281863H\n474707061\nItalian (native language)\nSpanish (read, written, spoken)\nEnglish (read, written, spoken)\nPortuguese (read, spoken)\nFrench (read)\n\t\t\nCurrent position (title and company)\tDate (Year)\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. Private practise.\t2017-today\n\n2019-today\n\t\n\t\nEducation (High school, university and postgraduate training > 3 months)\tDate (Year)\nDegree in Medicine and Surgery. University of Neaples 'Federico II”\nResident in Opthalmology. Hospital Clinico Universitario Valladolid\nMaster in Vitreo-Retina. IOBA. University of Valladolid\nFellow of the European Board of Ophthalmology. Paris\nMaster in Research in Ophthalmology. University of Valladolid\t2003-2009\n2012-2016\n2016-2017\n2016\n2012-2013\n\t\nEmployments (company and positions)\tDate (Year)\nResident in Ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl.\nFellow in Vitreo-Retina. IOBA. University of Valladolid\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. \n\t2012-2016\n2016-2017\n2017-today\n\n2019-Today\n\n\n\t\nClinical Research Experience (tasks and role)\tDate (Year)\nAssociated investigator\n\n' FIS PI20/00740: DESARROLLO DE UNA CALCULADORA DE RIESGO DE\nAPARICION DE RETINOPATIA DIABETICA BASADA EN TECNICAS DE IMAGEN MULTIMODAL EN PACIENTES DIABETICOS TIPO 1. Grant by: Ministerio de Ciencia e Innovacion \n\n' (BIO/VA23/14) Estudio clínico multicéntrico y prospectivo para validar dos\nbiomarcadores ubicados en los genes p53 y MDM2 en la predicción de los resultados funcionales de la cirugía del desprendimiento de retina regmatógeno. Grant by: Gerencia Regional de Salud de la Junta de Castilla y León.\n' Estudio multicéntrico, aleatorizado, con enmascaramiento doble, en 2 grupos\nparalelos y de 52 semanas de duración para comparar la eficacia, seguridad e inmunogenicidad de SOK583A1 respecto a Eylea® en pacientes con degeneración macular neovascular asociada a la edad' (CSOK583A12301; N.EUDRA: 2019-004838-41; FASE III). Grant by Hexal AG\n\n' Estudio de fase III, aleatorizado, doble ciego, con grupos paralelos, multicéntrico para comparar la eficacia y la seguridad de QL1205 frente a Lucentis® en pacientes con degeneración macular neovascular asociada a la edad. (EUDRACT: 2018-004486-13). Grant by Qilu Pharmaceutical Co\n\n' Estudio NEUTON: Ensayo clinico en fase IV para evaluar la eficacia de aflibercept en pacientes Naive con Edema MacUlar secundario a Oclusion de Vena CenTral de la Retina (OVCR) en regimen de tratamientO iNdividualizado Treat and Extend (TAE)”, (2014-000975-21). Grant by Fundacion Retinaplus\n\n' Evaluación de la seguridad y bioactividad de anillos de tensión capsular en conejo. Proyecto Procusens. Grant by AJL, S.A.\n\n'Estudio epidemiológico, prospectivo, multicéntrico y abierto\\npara valorar la frecuencia de la conjuntivitis adenovírica diagnosticada mediante el test AdenoPlus®\\nTest en pacientes enfermos de conjuntivitis aguda”\\n. National, multicenter study. Grant by: NICOX.\n\nEuropean multicentric trial: 'Evaluation of clinical outcomes following the use of Systane Hydration in patients with dry eye”. Study Phase 4. Grant by: Alcon Labs'\n\nVLPs Injection and Activation in a Rabbit Model of Uveal Melanoma. Grant by Aura Bioscience\n\nUpdating and characterization of a rabbit model of uveal melanoma. Grant by Aura Bioscience\n\nEnsayo clínico en fase IV para evaluar las variantes genéticas de la vía del VEGF como biomarcadores de eficacia del tratamiento con aflibercept en pacientes con degeneración macular asociada a la edad (DMAE) neovascular. Estudio BIOIMAGE. IMO-AFLI-2013-01\n\nEstudio In-Eye:Ensayo clínico en fase IV, abierto, aleatorizado, de 2 brazos,\nmulticçentrico y de 12 meses de duración, para evaluar la eficacia y seguridad de un régimen de PRN flexible individualizado de 'esperar y extender' versus un régimen PRN según criterios de estabilización mediante evaluaciones mensuales de inyecciones intravítreas de ranibizumab 0,5 mg en pacientes naive con neovascularización coriodea secunaria a la degeneración macular relacionada con la edad. CP: CRFB002AES03T\n\nTREND: Estudio Fase IIIb multicéntrico, randomizado, de 12 meses de\nseguimiento con evaluador de la agudeza visual enmascarado, para evaluar la eficacia y la seguridad de ranibizumab 0.5mg en un régimen de tratar y extender comparado con un régimen mensual, en pacientes con degeneración macular neovascular asociada a la edad. CP: CRFB002A2411 Código Eudra CT:\n2013-002626-23\n\n\n\nPublications\t\n\n2021\n\n\n\n\n2015\n\n\n\n\n2021\n\n\n\n\n\n2021\n\n\n\n\n2015\n\n\n\n\n2015\n\n\n2014\n\n\n\n\n2015-16\n\n\n\n2015\n\n\n2014\n\n\n2014\n\n\n\n\n2014\n\n\n\n\n\n\n\n2014\n\nJose Carlos Pastor; Jimena Rojas; Salvador Pastor-Idoate; Salvatore Di Lauro; Lucia Gonzalez-Buendia; Santiago Delgado-Tirado. Proliferative vitreoretinopathy: A new concept of disease pathogenesis and practical\nconsequences. Progress in Retinal and Eye Research. 51, pp. 125 - 155. 03/2016. DOI: 10.1016/j.preteyeres.2015.07.005\n\n\nLabrador-Velandia S; Alonso-Alonso ML; Di Lauro S; García-Gutierrez MT; Srivastava GK; Pastor JC; Fernandez-Bueno I. Mesenchymal stem cells provide paracrine neuroprotective resources that delay degeneration of co-cultured organotypic neuroretinal cultures.Experimental Eye Research. 185, 17/05/2019. DOI: 10.1016/j.exer.2019.05.011\n\nSalvatore Di Lauro; Maria Teresa Garcia Gutierrez; Ivan Fernandez Bueno. Quantification of pigment epithelium-derived factor (PEDF) in an ex vivo coculture of retinal pigment epithelium cells and neuroretina.\nJournal of Allbiosolution. 2019. ISSN 2605-3535\n\nSonia Labrador Velandia; Salvatore Di Lauro; Alonso-Alonso ML; Tabera Bartolomé S; Srivastava GK; Pastor JC; Fernandez-Bueno I. Biocompatibility of intravitreal injection of human mesenchymal stem cells in immunocompetent rabbits. Graefe's archive for clinical and experimental ophthalmology. 256 - 1, pp. 125 - 134. 01/2018. DOI: 10.1007/s00417-017-3842-3\n\n\nSalvatore Di Lauro, David Rodriguez-Crespo, Manuel J Gayoso, Maria T Garcia-Gutierrez, J Carlos Pastor, Girish K Srivastava, Ivan Fernandez-Bueno. A novel coculture model of porcine central neuroretina explants and retinal pigment epithelium cells. Molecular Vision. 2016 - 22, pp. 243 - 253. 01/2016.\n\nSalvatore Di Lauro. Classifications for Proliferative Vitreoretinopathy ({PVR}): An Analysis of Their Use in Publications over the Last 15 Years. Journal of Ophthalmology. 2016, pp. 1 - 6. 01/2016. DOI: 10.1155/2016/7807596\n\nSalvatore Di Lauro; Rosa Maria Coco; Rosa Maria Sanabria; Enrique Rodriguez de la Rua; Jose Carlos Pastor. Loss of Visual Acuity after Successful Surgery for Macula-On Rhegmatogenous Retinal Detachment in a Prospective Multicentre Study. Journal of Ophthalmology. 2015:821864, 2015. DOI: 10.1155/2015/821864\n\nIvan Fernandez-Bueno; Salvatore Di Lauro; Ivan Alvarez; Jose Carlos Lopez; Maria Teresa Garcia-Gutierrez; Itziar Fernandez; Eva Larra; Jose Carlos Pastor. Safety and Biocompatibility of a New High-Density Polyethylene-Based\nSpherical Integrated Porous Orbital Implant: An Experimental Study in Rabbits. Journal of Ophthalmology. 2015:904096, 2015. DOI: 10.1155/2015/904096\n\nPastor JC; Pastor-Idoate S; Rodríguez-Hernandez I; Rojas J; Fernandez I; Gonzalez-Buendia L; Di Lauro S; Gonzalez-Sarmiento R. Genetics of PVR and RD. Ophthalmologica. 232 - Suppl 1, pp. 28 - 29. 2014\n\nRodriguez-Crespo D; Di Lauro S; Singh AK; Garcia-Gutierrez MT; Garrosa M; Pastor JC; Fernandez-Bueno I; Srivastava GK. Triple-layered mixed co-culture model of RPE cells with neuroretina for evaluating the neuroprotective effects of adipose-MSCs. Cell Tissue Res. 358 - 3, pp. 705 - 716. 2014.\nDOI: 10.1007/s00441-014-1987-5\n\nCarlo De Werra; Salvatore Condurro; Salvatore Tramontano; Mario Perone; Ivana Donzelli; Salvatore Di Lauro; Massimo Di Giuseppe; Rosa Di Micco; Annalisa Pascariello; Antonio Pastore; Giorgio Diamantis; Giuseppe Galloro. Hydatid disease of the liver: thirty years of surgical experience.Chirurgia italiana. 59 - 5, pp. 611 - 636.\n(Italia): 2007. ISSN 0009-4773\n\nChapters in books\n\t\n' Salvador Pastor Idoate; Salvatore Di Lauro; Jose Carlos Pastor Jimeno. PVR: Pathogenesis, Histopathology and Classification. Proliferative Vitreoretinopathy with Small Gauge Vitrectomy. Springer, 2018. ISBN 978-3-319-78445-8\nDOI: 10.1007/978-3-319-78446-5_2. \n\n' Salvatore Di Lauro; Maria Isabel Lopez Galvez. Quistes vítreos en una mujer joven. Problemas diagnósticos en patología retinocoroidea. Sociedad Española de Retina-Vitreo. 2018.\n\n' Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor Jimeno. iOCT in PVR management. OCT Applications in Opthalmology. pp. 1 - 8. INTECH, 2018. DOI: 10.5772/intechopen.78774.\n\n' Rosa Coco Martin; Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor. amponadores, manipuladores y tinciones en la cirugía del traumatismo ocular.Trauma Ocular. Ponencia de la SEO 2018..\n\n' LOPEZ GALVEZ; DI LAURO; CRESPO. OCT angiografia y complicaciones retinianas de la diabetes. PONENCIA SEO 2021, CAPITULO 20. (España): 2021.\n\n' Múltiples desprendimientos neurosensoriales bilaterales en paciente joven. Enfermedades Degenerativas De Retina Y Coroides. SERV 04/2016. \n' González-Buendía L; Di Lauro S; Pastor-Idoate S; Pastor Jimeno JC. Vitreorretinopatía proliferante (VRP) e inflamación: LA INFLAMACIÓN in «INMUNOMODULADORES Y ANTIINFLAMATORIOS: MÁS ALLÁ DE LOS CORTICOIDES. RELACION DE PONENCIAS DE LA SOCIEDAD ESPAÑOLA DE OFTALMOLOGIA. 10/2014.",institutionString:null,institution:null},{id:"265335",title:"Mr.",name:"Stefan",middleName:"Radnev",surname:"Stefanov",slug:"stefan-stefanov",fullName:"Stefan Stefanov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/265335/images/7562_n.jpg",biography:null,institutionString:null,institution:null},{id:"243698",title:"Dr.",name:"Xiaogang",middleName:null,surname:"Wang",slug:"xiaogang-wang",fullName:"Xiaogang Wang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243698/images/system/243698.png",biography:"Dr. Xiaogang Wang, a faculty member of Shanxi Eye Hospital specializing in the treatment of cataract and retinal disease and a tutor for postgraduate students of Shanxi Medical University, worked in the COOL Lab as an international visiting scholar under the supervision of Dr. David Huang and Yali Jia from October 2012 through November 2013. Dr. Wang earned an MD from Shanxi Medical University and a Ph.D. from Shanghai Jiao Tong University. Dr. Wang was awarded two research project grants focused on multimodal optical coherence tomography imaging and deep learning in cataract and retinal disease, from the National Natural Science Foundation of China. He has published around 30 peer-reviewed journal papers and four book chapters and co-edited one book.",institutionString:null,institution:null},{id:"7227",title:"Dr.",name:"Hiroaki",middleName:null,surname:"Matsui",slug:"hiroaki-matsui",fullName:"Hiroaki Matsui",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Tokyo",country:{name:"Japan"}}},{id:"318905",title:"Prof.",name:"Elvis",middleName:"Kwason",surname:"Tiburu",slug:"elvis-tiburu",fullName:"Elvis Tiburu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Ghana",country:{name:"Ghana"}}},{id:"336193",title:"Dr.",name:"Abdullah",middleName:null,surname:"Alamoudi",slug:"abdullah-alamoudi",fullName:"Abdullah Alamoudi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"318657",title:"MSc.",name:"Isabell",middleName:null,surname:"Steuding",slug:"isabell-steuding",fullName:"Isabell Steuding",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Harz University of Applied Sciences",country:{name:"Germany"}}},{id:"318656",title:"BSc.",name:"Peter",middleName:null,surname:"Kußmann",slug:"peter-kussmann",fullName:"Peter Kußmann",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Harz University of Applied Sciences",country:{name:"Germany"}}},{id:"338222",title:"Mrs.",name:"María José",middleName:null,surname:"Lucía Mudas",slug:"maria-jose-lucia-mudas",fullName:"María José Lucía Mudas",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Carlos III University of Madrid",country:{name:"Spain"}}}]}},subseries:{item:{id:"90",type:"subseries",title:"Human Development",keywords:"Neuroscientific research, Brain functions, Human development, UN’s human development index, Self-awareness, Self-development",scope:"