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The Role of Exercise in Cancer Survivorship

Written By

Karen Y. Wonders

Submitted: November 29th, 2010 Published: January 27th, 2012

DOI: 10.5772/23625

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1. Introduction

At the turn of the 20th century, the outlook was bleak for individuals diagnosed with cancer. The pathophysiology of cancer was not well understood, and the associated treatments were as dire as the disease itself. In 1971, President Nixon declared “war” on cancer (Haran & DeVita, 2005). Since then we have seen dramatic improvements in cancer prognoses. At present, more than 11.7 million men and women are living as cancer survivors in the US, primarily due to early detection and advances in treatment options (Centers for Disease Control, 2007). However, such treatments often result in long-term physical and psychological toxicities, which negatively impact the cancer survivor's quality of life (QOL). These sequelae include, but are not limited to, decreased muscle strength, reduced cardiorespiratory fitness, reduced lean body mass, bone loss, fatigue (Pihkala et al., 1995; Lucia et al., 2003), depression, emotional distress, and anxiety (Jones et al., 2010). Thus, cancer research has shifted from its initial focus on prevention, to one that is centered on controlling or eliminating treatment-related toxicities with pharmacologic, physical, or social interventions. Now more than ever, healthy behavior choices are being promoted in attempt to limit this disease. In 2006, 42% of NIH-funded research projects contained an intervention component designed to improve the psychosocial well-being, physical status, and/or health behaviors of cancer survivors (National Institutes of Health, 2011). One such intervention, exercise rehabilitation, has been widely reported in the literature to benefit cancer patients. With more than two decades of literature examining this topic, research continues to support a link between a physically active lifestyle and improvements in mental and physical QOL in cancer survivors (Douglas, 2005; Wiggins & Simonavice, 2009). Thus, the primary aim of this chapter will be to explore the role of physical activity and exercise in cancer recovery.


2. Precautions during exercise

Cancer survivors often have disease or treatment-specific limitations that affect the exercise response. The specific effects of cancer on the exercise response are determined by the tissues affected and their level of involvement. Treatment-specific limitations arise from the type and duration of anticancer therapy employed. Surgery, chemotherapy, and radiation are the most common forms of cancer treatment, and all are associated with both acute and chronic effects that may negatively impact the exercise response. Table 1 briefly lists some of the more common treatment-related effects. In addition, most people are treated with a combination of surgery, radiation, and chemotherapy, which may cause a host of treatment-related problems. Pain, lymphedema, risk of infection, shortness of breath, neural deficits, fatigue, nausea and vomiting, cachexia, dehydration, and emotional distress are all common effects of cancer and its associated treatments on the patient’s exercise tolerance.

Cancer TreatmentPotential Side Effects
Loss of flexibility
Skin changes
Loss of flexibility
Cardiac and/or lung scaring
Muscle weakness
Changes in body composition that influence gait and balance.

Table 1.

Potential Side Effects of Anticancer Therapy (Swartz, 2009).

2.1. Pain

Depending on the specific location of the cancer, patients may experience high levels of pain. A tumor often causes pain, particularly when it involves the musculoskeletal system, causing it to press on bones, nerves, or body organs. In addition, chronic pain is frequently reported following surgery, often when large amounts of healthy tissue are removed along with cancer tissue. Chemotherapy and radiation treatments may also cause pain resulting from such side effects as peripheral neuropathy, mucositis, and radiation injuries (American Cancer Society, 2011). In most situations, physicians can prescribe medications to alleviate pain; however the intensity, type, duration, and frequency of exercise may need to be adjusted until the pain is brought under control.

2.2. Lymphedema

Lymphedema is a swelling that results from a blockage of the lymph vessels that drain fluid from tissues. It is commonly caused by a mastectomy or the removal of underarm lymph nodes during breast cancer surgery, and is experienced by approximately 10-15% of breast cancer patients (Muss, 2007). It is characterized by a persistent swelling, typically of the arm or leg. Often, patients may be treated with compression bandages to limit swelling. It is advised that exercises be carefully designed, so as not to increase the swelling or cause infection (Kercher et al., 2008).

2.3. Risk of infection

Chemotherapy, radiation, and immunotherapy often have a substantial impact on white blood cell count. Consequently, immune function often weakens during cancer treatment. Patients with very low blood counts are advised to avoid exercise all together, as they are at an increased risk for anemia. Frequent hand washing is advised, particularly in fitness centers, where germ count tends to be very high.

2.4. Shortness of breath

Shortness of breath is common when cancer has affected the lungs. It also may result when the bone marrow is affected, causing low red blood cell counts. Red blood cells carry oxygen throughout the body. Their ability to carry oxygen is measured by the amount of hemoglobin present in the blood. A low level of hemoglobin is indicative of anemia. With anemia, the body must work harder to supply oxygen to the tissues, causing the patient to feel fatigued and short of breath. Thus, anemic patients often have a limited aerobic performance because of the reduced oxygen-carrying capacity (Swartz, 2009).

2.5. Neural deficits

Neural deficits are common when tumors involve the central nervous system and brain. Problems with neural repair and decreased neurotransmitter activity may also arise as a side effect of anticancer therapy, related to the ability of chemotherapy to cross the blood-brain barrier and cause DNA damage and shortened telomere length (Klein, 2009). Neurological deficits can impact memory and emotion in cancer patients and may influence their motivation to adhere to an exercise program.

2.6. Fatigue

Fatigue is the most frequently reported symptom of cancer treatment (Schneider et al., 2003), affecting up to 96% of patients (Douglas, 2005). It is a whole-body tiredness that interferes with normal functioning and leaves the patient feeling irritable and unmotivated. Chronic fatigue has a negative impact on activities of daily life, social reintegration, and overall quality of life (Hartvig et al., 2006). In some patients, this fatigue is so debilitating to the individual that treatment must be discontinued or limited (Schneider et al., 2003).

2.7. Nausea and vomiting

Nausea, vomiting, and diarrhea are common effects of radiation and chemotherapy, leaving the patient feeling weak and at risk for electrolyte imbalances and dehydration. Cancer patients should avoid exercise for 24-hours after bouts of vomiting and diarrhea (Young-McCaughan, 2006). As a result, it is important that exercise schedules be flexible to accommodate these bouts of irritation. Research indicates that in some instances, exercise will reduce feelings of nausea. However, if nausea persists upon initiation of exercise, activity should be stopped (Young-McCaughan, 2006).

2.8. Cachexia

Cachexia is a physical wasting syndrome accompanied by loss of muscle mass, fat mass, overall weight, and appetite. It affects up to 75% of cancer patients, especially those who are in the advanced stages of pancreas, esophagus, and stomach cancer. It is a metabolic disturbance that can result in electrolyte imbalances, weakness, fatigue, and reduced strength. Often, treatment with nutrient supplementation is ineffective (Martingnoni et al., 2003). Patients suffering from cachexia often lack the energy to exercise, so little is known about the impact of exercise on this condition.

2.9. Dehydration

Dehydration is often experienced during chemotherapy, either as a side effect of frequent vomiting and diarrhea, or as a direct effect on the kidneys. Large quantities of water are necessary to help the kidneys filter chemotherapy medication. Fatigue and dizziness are symptoms of dehydration, both of which will impact the exercise response. It is important to ensure adequate fluid intake before, during, and after each exercise session.

2.10. Emotional distress

Cancer survivors will face a multitude of emotions as they battle cancer, creating a strain on interpersonal relationships. These emotions may include anger, depression, anxiety, and elation. This emotional distress can significantly impact a cancer patient’s desire to participate in an exercise program.


3. Benefits of exercise

3.1. Risk factors

Not all risk factors that predispose an individual to cancer can be controlled (i.e., age, gender, race, genetic factors). However, healthy behaviors and lifestyle choices, along with environmental exposure risk reduction, can help reduce cancer development. Fifty to 75% of cancer deaths in the US are related to risk factors such as smoking, poor dietary choices, and physical inactivity (National Cancer Institute, 2009). Specifically, obesity and physical inactivity are associated with approximately 25-30% of colon, breast, endometrial, kidney, and esophageal cancers in the US (National Cancer Institute, 2009). The World Health Organization lists physical activity among the nine modifiable risk factors for cancer (World Health Organization, 2009). In addition, recent research supports the assertion that physical activity helps to prevent certain forms of cancer (Kruk, 2007; Miles, 2007), including cancer of the colon (Courneya & Friedenreich, 2007), breast (Courneya & Friedenreich, 2007), endometrium (Courneya & Friedenreich, 2007), prostate (Courneya & Friedenreich, 2007; Friedenreich & Orenstein, 2002), lung (Courneya & Friedenreich, 2007; Friedenreich & Orenstein, 2002), kidney (Friedenreich & Orenstein, 2002), rectus (Friedenreich & Orenstein, 2002), and esophagus (Friedenreich & Orenstein, 2002) cancer. The average risk reduction for each of these cancers varies from approximately 10-40% (Wiggins & Simonavice, 2010). Moderate physical activity (>4.5 METs) appears to be associated with a greater protective effect than activities of lower intensity (Lee, 2003).

3.1.1. Cancer survivorship

In addition to reducing the risk of developing certain forms of cancer, physical activity has also been suggested to increase cancer survivorship by decreasing the risk of cancer recurrence, slowing the progression of cancer, and reducing the risk of secondary life-threatening diseases (Courneya & Friedenreich, 2007; Holmes et al., 2005; Haydon et al., 2005). One investigation (Holmes et al., 2005), revealed a reduction of 26-40% in the relative risk of breast cancer-related death and recurrence among the most active women compared with the least active. Similarly, higher levels of physical activity pre- and post-diagnosis of colon cancer and post-diagnosis of colorectal cancer were associated with a decrease in cancer-related mortality (Haydon et al., 2006; Meyerhardt et al., 2006a, 2006b). As such, the American Cancer Society recommends that exercise serve as an important part of an individual’s cancer care plan, asserting that exercise will decrease feelings of fatigue both during and after treatment, and improve an individual’s feeling of control and hope (American Cancer Society, 2011). In addition, the 2008 US Department of Health and Human Services (US DHHS) Physical Activity Guidelines for Americans indicate that individuals with chronic conditions, such as cancer, should be “as physically active as their abilities and conditions allow” (Physical Activities Guidelines Advisory Committee, 2008).

3.2. General health benefits of exercise

The general health benefits associated with participating in an exercise program are numerous, and include: improved cardiac output, increased ventilation; improved flexibility and range of motion; increased muscular strength and endurance; decreased resting heart rate; improved stroke volume, vasodilation, perfusion; improved metabolic efficiency; and improved blood counts (Wilmore et al., 2008). Likewise, there are several positive physiological and psychological changes for cancer survivors associated with moderate levels of physical activity and structured exercise.

3.2.1. Aerobic capacity

Research indicates that individuals being treated for cancer have the potential to significantly increase their aerobic capacity by engaging both home-based and structured exercise programs. Young-McCaughan et al (2003) reported an increase in VO2max in cancer survivors following a 12-week exercise program. Thorsen et al (2005) found a significant increase in VO2max for cancer survivors following a 14-week home training program. Wiggins and Simonavice (2008) reported an increase in VO2max in breast cancer survivors after 3 months of resistance and aerobic training. Improvements in VO2max will enhance heart and lung functioning, thereby promoting healthy a blood pressure, blood volume, and gas exchange (Swartz, 2009). In addition, beneficial effects on energy balance, body mass, intestinal transit time, hormone concentrations, and antioxidant enzyme levels have been observed following improvements in aerobic capacity. Research also indicates an inverse relationship between fatigue and aerobic capacity, in that the higher an individual’s aerobic capacity, the lower their levels of fatigue, which translates into a positive influence on QOL (DeVita et al., 2008).

3.2.2. Muscular strength and endurance

Several studies report improvements in muscular strength and endurance as a result of participating in an exercise program. In one study, muscular strength increased by approximately 41% in patients who participated in a 6-week resistance training program (Quist et al., 2006). Likewise, a 12-month exercise program resulted in increases in upper body muscular strength and lower body endurance in breast cancer survivors (Wiggins & Simonavice, 2008). Finally, Cheema and Gual (2006) reported improvements in upper and lower body muscular endurance in previously trained breast cancer survivors following an 8-week exercise program. Increased levels of muscular strength and endurance have a positive effect on body composition, and is therefore associated with lower cancer mortality risk (American Heart Association, 2011).

3.2.3. Psychosocial measures

A favorable link between exercise and fatigue, psychosocial measures, and QOL has been reported in the literature. Historically, rest was the most common medical advice given for the treatment of fatigue (Courneya et al., 2000; Coon & Coleman, 2004; Meyerowitz et al., 1983). Unfortunately, this can lead to even more fatigue (Schneider et al., 2003), as well as to aerobic de-conditioning and a lower functional capacity (Courneya et al., 2005). Conversely, several investigations have found that exercise is beneficial in reducing the fatigue experienced by individuals undergoing cancer treatment (Dimeo et al., 1996; Mock et al., 2007; Schwartz et al., 2001; Segal et al., 2001). In general, fatigue tends to subside within the first 5-10 minutes of activity. In terms of long-term improvement, research indicates that regular aerobic exercise over a period of 6 months improved endurance in breast cancer survivors (Damush et al., 2005) and decreased fatigue in patients with prostate and Hodgkin Disease (Watson & Mock, 2004).

Improvements in QOL (Wiggins & Simonavice, 2008, 2009; Courneya et al., 2009), anxiety (Courneya et al., 2003, 2000), depression (Courneya et al., 2003, 2000; Pirl & Roth, 1999), body image (Pinto et al., 2003), immune function (Galvo & Newton, 2005), and emotional well-being (Courneya et al., 2003) have also been reported following structured exercise programs. This holds true, even when cancer treatment has failed. It is believed that feelings of self-confidence and hope are directly related to the restored energy levels obtained through improved cardiorespiratory functioning. In addition, chronic exercise leads to a reduction in obesity and improved gastrointestinal functioning, both of which improve self-image and overall outlook on life (Harriss et al., 2007).

3.2.4. Cancer-specific benefits

A concern with cancer survivors is that they often have comorbid conditions that will influence exercise prescription and management. More often than not, these comorbidities result from the very medications that are used to fight cancer. The good news, however, is that in most cases, exercise has been found to exert a positive effect on these toxicities. An outline of some of these conditions and the associated benefits of exercise is presented in Table 2. It should be noted that, for these adverse effects of cancer treatment, there may be predisposing factors which will influence the severity of the treatment effects.


4. Components of an exercise program

As demonstrated above, exercise is safe and effective both during and after most types of cancer treatment, and should therefore be included as an integral part of an individual’s cancer care plan. The American Cancer Society recommends that exercise be part of a continuum of cancer survival care, spanning from treatment to recovery, as well as after-recovery maintenance and living-with-advanced-cancer (Doyle et al., 2006). At present, exercise and cancer recovery programs specifically designed for survivors are being implemented all over the country. The following protocols for exercise training with cancer patients are those employed by the Maple Tree Cancer Alliance® (MTCA®), a cancer rehabilitation center in southwest Ohio dedicated to improving the quality of life of individuals afflicted with cancer by focusing on their physical and spiritual needs. All procedures used by MTCA® follow the guidelines set forth by the American College of Sports Medicine (ACSM). Typically, the training sessions resemble that of a general exercise program, in that they often involve an aerobic component, resistance training, and flexibility exercises. However, given the unique challenges imposed by working with cancer survivors, ACSM recommends that fitness professionals working with cancer patients obtain a specialized training certification prior to training this group of individuals (Schneider & Carter, 2003).

Cancer Treatment ToxicityEffect of Exercise
Muscular Degeneration:

Cancer treatments damage muscle tissue. Muscle damage may be severe enough to cause weakness and fatigue.
Exercise increases the integrity of muscle tissue and protein synthesis, stimulates the release of numerous hormones that increase muscle cell growth and development, and improves metabolism (DeVita et al., 2001; Fischer et al., 2003).

Cancer treatments cause a decrease in motor function.
Exercise can enhance motor unit recruitment and improve neurochemical availability at the cellular and tissue levels (Fischer et al., 2003; Snyder, 1986).

Cancer treatments cause: decreased left ventricular dysfunction, reduced ejection fraction, diminished contractility, reduced cardiac output and stroke volume, decreased nutrient and oxygen delivery to tissues
Exercise can improve cardiovascular efficiency by strengthening the myocardium, increasing cardiac output and stroke volume, and decreasing resting heart rate and lowering exercise heart rate (DeVita et al., 2001; Fischer et al., 2003).
Pulmonary Toxicity:

Cancer treatments cause a disruption in the structural integrity of the airways
Exercise can improve ventilation and transport of oxygen from the environment to the cellular level (Chabner & Longo 2010; Wilson, 1978).

Table 2.

Persistent Effects of Cancer Treatments Relative to Exercise Training.

4.1. Phase 1: Exercise during treatment

The following procedures will assist the fitness trainer to design a safe and effective exercise program for patients who are currently undergoing cancer treatment.

4.1.1. Prescreening

Given that cancer survivors often have limitations that pose challenges to exercise, it is necessary that the exercise intervention be individualized according to the needs of each patient. Current health status, cancer treatments, and anticipated disease trajectory must all be taken into consideration by the fitness trainer before designing an exercise program (Schmitz et al., 2010). Therefore, it is important that fitness professionals work closely with physicians and understand the specifics of the cancer survivor’s diagnosis and treatments received, including existing health conditions and fitness level prior to cancer diagnosis. This is best obtained through comprehensive prescreening paperwork, which should include information regarding health history, cancer history, and psychological status, along with a medical examination and physician referral (Schneider et al., 2003).

4.1.2. Fitness assessment

Once the prescreening paperwork is completed and reviewed, the patient’s current level of fitness should be evaluated through a comprehensive fitness assessment. A comprehensive fitness assessment is one that measures body composition, cardiorespiratory fitness, muscular strength and endurance, flexibility, balance, and range of motion. Specifically, ACSM recommends a graded treadmill or bicycle ergometer test to assess cardiovascular function, a spirometer test for pulmonary function, dumbbells or resistance machines for muscular strength and endurance tests, and the modified sit and reach for flexibility assessment (Schneider & Carter, 2003). In most cases, cancer patients can tolerate the standardized assessment protocols (Swartz, 2009); however, adaptations for certain exercise tests may be necessary if the patient has limited mobility or impaired functioning. Pictures of standard assessments are shown below (Figures 1-5).

Figure 1.

Muscular Strength Assessment.

Figure 2.

Muscular Endurance Assessment.

Figure 3.

Flexibility Assessment.

Figure 4.

Body Composition Assessment.

Figure 5.

Cardiovascular Endurance Assessment.

Fitness assessments are useful to quantitatively monitor progress during exercise training. Of note, however, is the fact that cancer-specific norms have not yet been developed. Therefore, the scores received by the cancer patient during his/her fitness assessment are compared to norm charts from a healthy population. This must be taken into consideration during goal setting, particularly for those individuals who are currently undergoing treatment. Typically, for these individuals, as well as patients with recurrent disease, the goal of the exercise program should be simply to preserve function. It is important to have realistic expectations for the exercise intervention so that the patient does not become discouraged, as research indicates that adherence to an exercise intervention is a challenging task (Markes et al., 2006).

4.1.3. Exercise prescription

Once the fitness assessment has been completed and reviewed, the fitness trainer may design an individualized exercise prescription for the patient. An exercise prescription is a plan of fitness-related activities designed for a specific purpose. In other words, an exercise prescription is a prescription for exercise. Recommendations pertaining to the frequency, intensity, duration, mode, and progression of exercise must be addressed. Ideally, for an individual undergoing cancer treatment, the prescription will include a whole-body workout that targets all the major muscle groups. The overall goal of the exercise program should be to minimize the general de-conditioning that often results from cancer treatment so that the cancer treatments are better tolerated. In general, the exercise prescription should include a slow progression and demonstrate adaptability to changes in the patient’s health status, which frequently will change from day-to-day during treatment. According to ACSM (Schmitz et al., 2010), the general objectives for exercise training among cancer survivors are as follows:

  1. To regain and improve physical function, aerobic capacity, strength, and flexibility.

  2. To improve body image and QOL.

  3. To improve body composition.

  4. To improve cardiorespiratory, endocrine, neurological, muscular, cognitive, and psychosocial outcomes.

  5. Potentially, to reduce or delay recurrence or a second primary tumor.

  6. To improve the ability to physically and psychologically withstand the ongoing anxiety regarding recurrence or a second primary cancer.

  7. To reduce, attenuate, and prevent long-term and late effects of cancer treatment.

  8. To improve the physiologic and psychological ability to withstand any current or future cancer treatments.

At present, the optimal frequency, duration, and time course of adaptation to aerobic and resistance exercise training in cancer patients are not known, although research indicates that individuals undergoing cancer therapy benefit from low-to-moderate intensity aerobic and resistance exercise (Swartz, 2009). Based on available data, Table 3 presents some general guidelines a fitness professional may follow when designing an exercise program (Schmitz et al., 2010; Physical Activities Guidelines Advisory Committee, 2008; Haskell et al., 2007; Schneider & Carter, 2003).

Initially, intensity will depend on the patient’s functional status and exercise history prior to cancer diagnosis. Typically, previously active cancer patients may continue their exercise regimen, although intensity may need to be decreased during treatment. Progression should consist of increases in frequency and duration rather than in intensity (Physical Activities Guidelines Committee, 2008; Schneider & Carter, 2003). To assist in progression, patients should be reassessed approximately every 6 months (Schneider & Carter, 2003).

Aerobic TrainingStrength TrainingFlexibility Training
Frequency3-5 days/wk2-3 days/wk2-7 days/wk
Intensity40-60% HRR*40-60% HRR*Stretch to the point of mild discomfort
Duration20-60 min/session1-3 sets, 8-12 reps per exercise10-30 seconds per stretch
ModeWalking, cycling, cross trainers, swimmingFree weights, machines, resistance bands, resistance ballsStatic stretching

Table 3.

Guidelines for Designing an Exercise Prescription for Individuals Undergoing Cancer Treatment. *HRR = Heart Rate Reserve HRR = [(Maximum Heart Rate – Resting Heart Rate) x % Intensity] + Resting Heart Rate.

4.1.4. Supervised exercise sessions

Once the individualized exercise prescription has been created, the patient may begin supervised training sessions with the fitness professional. Prior to each exercise session, it is advisable to assess the patient’s readiness to exercise. Resting heart rate and blood pressure should be measured, and general information regarding the patient’s overall health status should be obtained. Contraindications to exercise are listed in Table 4. Depending on the information attained, the exercise intervention may need to be adjusted for that day.

Onset of nausea following exercise initiation
Vomiting within the last 24 hours
Leg pain
Decreased heart rate and blood pressure with increased workload
Chest pain
Difficult or shallow breathing
Unusual muscle weakness
Numbness in the extremities
Chemotherapy treatment within the last 24-hours
Irregular pulse during exertion
Disorientation and confusion

Table 4.

Contraindications to exercise in cancer patients.

Each session should begin with a 5- to 10-minute warm-up that stimulates blood flow to the working muscles. The warm-up should involve some mild stretching and light aerobic activity. During the aerobic component of exercise, it is important to frequently monitor blood pressure and heart rate. If the patient is on a medication that affects heart rate, the Borg Scale of Exertion (Borg, 1973) (Figure 6) may be used to monitor intensity. Based on this scale, a light-to-moderate intensity (RPE of 11 to 14) should be encouraged. If dizziness, nausea, or chest pain occurs, all exercise should be stopped. Frequent short breaks are sometimes encouraged to accommodate therapy-related fatigue. Aerobic exercise should be followed up by static stretching and range of motion exercises for all major muscle groups.

Figure 6.

The Borg Scale Rating Perception of Effort (RPE).

The type of resistance exercise performed will depend on the patient’s range of motion, tissue removal, and wound healing. ACSM recommends at least 48 hours of rest between each resistance training session (Schneider & Carter, 2003). Therefore, it may be advisable to plan a whole body approach to resistance training, where all major muscle groups are targeted in one day. If the patient is unwilling or unable to participate in traditional modes of strength training, Yoga or Pilates may serve as an alternative form of strength exercise. Sample exercises are shown in pictures below (Figures 7-10).

At the conclusion of the exercise session, the patient should perform a 5-10 minute cool down along with some mild stretching. Sample stretches are shown in the pictures below (Figures 11 and 12). A proper cool down will reduce the potential for muscle soreness, decrease post-exercise dizziness, and allow the heart rate to return to its resting state.

4.2. Phase 2: Exercise after cancer recovery

For patients who have completed cancer therapy, exercise is important to maintain or improve function and prevent the development of diseases associated with inactivity (i.e. diabetes, cardiovascular disease, obesity) (Swartz, 2009). The objective of exercise training during cancer recovery should be to return the patient to their former level of physical function and make exercise an integral part of everyday life. Some side effects of anticancer medications do not appear for months or years after the discontinuation of treatment, therefore it is advised to maintain contact with the patient’s physician, in order to monitor any changes in health status. The fitness professional should follow the same general guidelines and procedures listed above when working with a cancer survivor.

Figure 7.

Lat Pull Down.

Figure 8.

Lateral Chest Press.

Figure 9.

Shoulder Press.

Figure 10.

Leg Press.

Figure 11.

Lower body stretch.

Figure 12.

Upper body stretch.


5. Conclusion

Two decades of research support the assertion that exercise is both safe and beneficial during cancer treatment. Most standard exercise protocols are well tolerated by patients. However, it is important that the fitness professional be aware of the specific effects of cancer and its treatments on the exercise response. Exercise prescriptions must be individualized according to the specific needs and health status of each patient. During each exercise session, modifications may need to be made to ensure patient safety, depending on the changing health of each patient. With the right program, remaining physically active during and after cancer treatment will improve the patient’s muscular strength and aerobic functioning, decrease fatigue, improve QOL and have a favorable effect on anxiety.


  1. 1. Activities Guidelines Advisory Committee. 2008 Physical Activity Guidelines Advisory Committee Report. US Department of Health and Human Services, Philadelphia, PA.
  2. 2. American Cancer Society. 2010 Pain Control. Date of access: April 13, 2011. Available from: Cancer Society. (2010). Pain Control. Date of access: April 13, 2011. Available from:
  3. 3. American Cancer Society. 2011 Stay Healthy. Healthy living information to help you stay well. Date of access: March 24, 2011. Available from:
  4. 4. American Heart Association. 2011 Physical Activity. Date of Access: April 14, 2011. Available from:
  5. 5. BorgG. A. V. 1973 Rating Perception of Effort. Lippincott, Williams, & Wilkins, Philadelphia, PA.
  6. 6. CellaD.LaiJ. S.ChangC. H.PetermanA.SlavinM. 2002 Fatigue in cancer patients compared with fatigue in the general United States population. CellaD.LaiJ. S.ChangC. H.PetermanA.SlavinM. (2002). Fatigue in cancer patients compared with fatigue in the general United States population. Cancer, 94, No. 2, pp. 528-38., 94, 2 528538 .
  7. 7. Centers for Disease Control and Prevention. 2007 Cancer survivors-United States, 2007. MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports / Centers for Disease Control, 60,9, 269272 .
  8. 8. ChabnerB. A.LongoD. L. 2010 Cancer Chemotherapy and Biotherapy (5th ed.). Lippincott Williams & Wilkins, 101605474312 PA.
  9. 9. CheemaB. S. B.GualC. A. 2006 Full-body exercise training improves fitness and quality of life in survivors of breast cancer. Journal of Strength and Conditioning Research, 20, 1 1421 .
  10. 10. CoonS. K.ColemanE. A. 2004 Keep moving: Patients with myeloma talk about exercise and fatigue. Oncology Nursing Forum. 31, 6 11271135 .
  11. 11. CourneyaK. S.FriedenreichC. M. 2007 Physical activity and cancer control. Seminars in Oncology Nursing, 23, 242252 .
  12. 12. CourneyaK. S.FriedenreichC. M.QuinneyH. A.FieldsA. L. A.JonesL. W.FaireyA. S. 2003 A randomized trial of exercise and quality of life in colorectal cancer survivors. European Journal of Pharmacology, 12 34757 .
  13. 13. CourneyaK. S.KeatsM. R.TurnerA. R. 2000 Physical exercise and quality of life in cancer patients following a high dose chemotherapy and autologous bone marrow transplatation. Psycho-oncology. 9, 2 127136 .
  14. 14. CourneyaK. S.StellarC. M.StevinsonC.Mc NeelyM. L.PeddleC. J.FriedenreichC. M.TankelK.BasiS.ChuaN.MazurekA. 2009 Randomized controlled trial of the effects of aerobic exercise on physical functioning and quality of life in lymphoma patients. Journal of Clinical Oncology, 27, 27 46054612 .
  15. 15. CourneyaK. S.VallanceJ. K. H.JonesL. W.ReimanT. 2005 Correlates of exercise interventions in non-Hodgkin’s lymphoma survivors: An application of the Theory of Planned Behavior. Journal of Sport and Exercise Psychology, 27, 335349 .
  16. 16. DamushT.PerkinsA.MillerK. 2006 The implementation of an oncologist referred, exercise self-management program for older breast cancer survivors. Psycho-oncology 15, 10 884890 .
  17. 17. De VitaV. T.HellmanS.RosenbergS. A. 2001 Cancer: Principles and Practice of Oncology (6th ed.). Vols. 1 and 2. Lippincott-Williams & Wilkins, 100781722292 PA.
  18. 18. De VitaV. T.LawrenceT. S.RosenbergS. A. 2008 Supportive Care and Quality of Life. In: Cancer: Principles & Practice of Oncology. 2 (8th ed.). 2796 Lippincott Williams & Wilkins, 10 PA.
  19. 19. DimeoF.BertzH.FindeJ.FetscherS.MertelsmannR.KuelJ. 1996 An aerobic exercise program for patients with haematological malignancies after bone marrow transplantation. DimeoF.BertzH.FindeJ.FetscherS.MertelsmannR.KuelJ. (1996). An aerobic exercise program for patients with haematological malignancies after bone marrow transplantation. Bone Marrow Transplantation, 18, No. 6, pp. 1157-60., 18, 6 11571160 .
  20. 20. DouglasE. 2005 Exercise in cancer patients. The Physical Therapy Review, 10, 7188 .
  21. 21. DoyleC.KushiL.ByersT.CourneyaK. S.Denmark-WahnefriedW.GrantB.Mc TiernanA.RockC. L.ThompsonC.GanslerT.AndrewsK. S. 2006 Nutrition and physical activity during and after cancer treatment: an American Cancer Society guide for informed choices. Cancer Journal for Clinicians, 56, 6 323353 .
  22. 22. FischerD. S.KnobfM. T.DurivageH. J. 2003 The Cancer Chemotherapy Handbook (6th ed.). Mosby, 100323018904 Louis.
  23. 23. FriedenreichC. M.OrensteinM. R. 2002 Physical activity and cancer prevention: Etiologic evidence and biological mechanisms. The Journal of Nutrition, 132, 54565464 .
  24. 24. GalvoD. A.NewtonR. U. 2005 Review of exercise intervention studies in cancer patients. Journal of Clinical Oncology, 23, 4 4 899909 .
  25. 25. HaranC.De VitaV. 2005 The view from the top. Cancer World, 6 (June, 2005), 3843 .
  26. 26. HarrissD.CableT.GeorgeK.ReillyT.RenenanA. G.HaboubiN. 2007 Physical activity before and after diagnosis of colorectal cancer. Sports Medicine, 37, 11 947960 .
  27. 27. HartvigP.AulinJ.HugerthM.WallenbergS.WageniusG. 2006 Fatigue in cancer patients treatedwith cytotoxic drugs. Journal of Oncology Pharmacy Practice, 12, 3 155164 .
  28. 28. HaskellW. L.LeeI. M.PateR. R.PowellK. E.BlairS. N.FranklinB. A.MaceraC. A.HeathG. W.ThompsonP. D.BaumanA. 2007 Physical activity and public health: Updated recommendation for adults from the American College of Sports Medicine and the American Heart Association. Medicine and Science in Sports and Exercise, 39, 8 14231434 .
  29. 29. HaydonA. M.MacinnisR.EnglishD.GilesG. G. 2006 The effect of physical activity and body size on survival after diagnosis with colorectal cancer. Gut, 55, 1 6267 .
  30. 30. HolmesM. D.ChenW. Y.FeskanichD.KroenkeC. H.ColditzG. A. 2005 Physical activity and survival after breast cancer diagnosis. JAMA, 293, 20 24792486 .
  31. 31. JonesJ. M.ChengT.JackmanM.RodinG.WaltonT.CattonP. 2010 Self-efficacy, perceived preparedness, and psychological distress in women completing primary treatment for breast cancer. Journal of Psychosocial Oncology, 28, 3 269290 .
  32. 32. KercherK.FleischerA.YosipovitchG. 2008 Lower extremity lymphedema update: pathophysiology, diagnosis, and treatment guidelines. Journal of the American Academy of Dermatology, 59, 2 2 32431 .
  33. 33. KleinM. 2009 Immunobiological and neural substrates of cancer-related neurocognitive deficits. The Neuroimmunological Basis of Behavior and Mental Disorders, 3, 327340 .
  34. 34. KrukJ. 2007 Physical activity in the prevention of the most frequent chronicdiseases: An analysis of the recent evidence. Asian Pacific Journal of Cancer Prevention, 8, 325338 .
  35. 35. LeeI. M. 2003 Physical activity and cancer prevention- data from epidemiologic studies. Medicine and Science in Sports and Exercise, 35, 11 18231827 .
  36. 36. LuciaA.EarnestC.PerezM. 2003 Cancer-related fatigue: Can exercise physiology assist oncologists? The Lancet Oncology, 4, 10 616625 .
  37. 37. MarkesM.BrockowT.ReschK. L. 2006 Exercise for women receiving adjuvant therapy for breast cancer. Cochrane Database of Systematic Reviews (Online), 18, 4 CD005001
  38. 38. MartingnoniM.KunzeP.FriessH. 2003 Cancer Cachexia. Molecular Cancer, 2, 36
  39. 39. MeyerhardtJ. A.GiovannucciE. L.HolmesM. D.ChanA. T.ChanJ. A.ColditzG. A.FuchsC. S. 2006 Physical activity and survival after colorectal cancer diagnosis. Journal of Clinical Oncology, 24, 22 35273534 .
  40. 40. MeyerhardtJ. A.HeseltineD.NiedzwieckiD.HollisD.SaltzL. B.MayerR. J.ThomasJ.NelsonH.WhittomR.HantelA.SchilskyR. L.FuchsC. S. 2006 Impact of physical activity on cancer recurrence and survival in patients with stage III colon cancer: Findings from CALGB 89803. Journal of Clinical Oncology, 24, 22 35353541 .
  41. 41. MeyerowitzB. E.WatkinsI. K.SparksF. C. 1983 Quality of life for breast cancer patients receiving adjuvant chemotherapy. The American Journal of Nursing, 83, 2 232235 .
  42. 42. MilesL. 2007 Physical activity and the prevention of cancer: A review of recent findings. Nutrition Bulletin, 32, 250282 .
  43. 43. Mock, V., Dow, K.H., Meares, C.J., Grimm, P.M., Dienemann, J.A., Haisfield-Wolfe, M.E., Quitasol, W.,
  44. 44. MitchellS.ChakravorthyA.GageI. 2007 Effects of exercise on fatigue, physical functioning, and emotional distress during radiation therapy for breast cancer. Oncology Nursing Forum, 24, 6 9911000 .
  45. 45. MussH. B. 2007 Breast cancer and differential diagnosis of benign lesions. In Cecil Medicine (23rd ed.), Goldman. L., Ausiello, D., eds. 15011509 , Saunders Elsevier, 101416028056 PA.
  46. 46. National Cancer Institute. 2009 Cancer Trends Progress Report- 2007. Date of access: March 28, 2011. Available from
  47. 47. National Institutes of Health. 2011 Estimates of Funding for Various Research,Condition, and Disease Categories. Date of access: March 24, 2011. Available from:
  48. 48. PihkalaJ.HapponenJ. M.VirtanenK.SouijarviA.SimesM. A.PesonenE.SaarinenU. M. 1995 Cardiopulmonary evaluation of exercise tolerance after chest irradiation and anticancer chemotherapy in children and adolescents. Pediatrics. 95, 5 722726 .
  49. 49. PintoB.ClarkM.MaruyamaN.FederF. 2003 Psychological and fitness changes associated with exercise participation among women with breast cancer. Psycho-oncology. 12, 2 118126 .
  50. 50. PirlW. F.RothA. J. 1999 Diagnosis and treatment of depression in cancer patients. Oncology 13, 9 12931301 .
  51. 51. QuistM.RorthM.ZachoM.AndersenC.MoellerT.MidtgaardJ.AdamsenL. 2006 High-intensity resistance and cardiovascular training improve physical capacity in cancer patients undergoing chemotherapy. Scandinavian Journal of Medicine & Science in Sports, 16, 5 349357 .
  52. 52. SchneiderC. M.CarterS. 2003 The role of exercise in recovery from cancer treatment. Rocky Mountain Cancer Rehabilitation Institute. ACSM Fit Society Page, 6, 9
  53. 53. SchneiderC. M.DennehyC. A.CarterS. D. 2003 Exercise and Cancer Recovery. Human Kinetics, 10736036458 IL.
  54. 54. SchmitzK. H.CourneyaK. S.MatthewsC.Demark-WahnefriedW.GalvalD. A.PintoB. M.IrwinM. L.WolinK. Y.SegalR. J.LuciaA.SchneiderC. M.vonGruenigen. V. E.SchwartzA. L. 2010 American College of Sports Medicine Roundtable on Exercise Guidelines for Cancer Survivors. Medicine and Science in Sports and Exercise, 42, 7 7 140926 .
  55. 55. SchwartzA. I.MoriM.GaoR.NailL. M.KingM. E. 2001 Exercise reduced daily fatigue in women with breast cancer receiving chemotherapy. Medicine and Science in Sports and Exercise, 33, 5 718723 .
  56. 56. SegalR.EvansW.JohnsonD.SmithJ.CollettaS.GaytonJ.WoodardS.WallsG.ReidR. 2001 Structured exercise improves physical functioning in women with stages I and II breast cancer: Results of a randomized controlled trial. Journal of Clinical Oncology, 19, 3 657665 .
  57. 57. SnyderC. C. 1986 Oncology Nursing. Little Brown, Boston.
  58. 58. SwartzA. L. 2009 Cancer, In: ACSM’s Exercise Management for Persons with Chronic Diseases and Disabilities (3rd ed.). Durstine, J.L., Moore, G.E., Painter, P.L., Roberts, S.O., (Eds.). 211218 , Human Kinetics, 100736074333 IL.
  59. 59. ThorsenL.SkovlundE.StrommeS. B.HornslienK.DahlA. A.FossaS. D. 2005 Effectiveness of physical activity on cardiorespiratory fitness and health-Related quality of life in young and middle-aged cancer patients after chemotherapy. Journal of Clinical Oncology, 23, 10 23782388 .
  60. 60. WatsonT.MockV. 2004 Exercise as an intervention for cancer-related fatigue. Physical Therapy, 84, 8 736743 .
  61. 61. WigginsM. S.SimonaviceE. M. 2008 Quality of life benefits: A 12-month exercise cancer recovery casestudy. KAHPERD Journal. 44, 1619 .
  62. 62. WigginsM. S.SimonaviceE. M. 2009 Quality of life benefits in cancer survivorship with supervisedexercise. Physiological Reports, 104, 2 2 42124 .
  63. 63. WigginsM. S.SimonaviceE. M. 2010 Cancer prevention, aerobic capacity, and physical functioning in survivors related to physical activity: A recent review. Cancer Management and Research, 2, 157164 .
  64. 64. WilmoreJ. H.CostillD. L.KenneyW. L. 2008 Physiology of Sport and Exercise. (4th ed.). Human Kinetics. 10 IL.
  65. 65. WilsonJ. K. V. 1978 Pulmonary toxicity of antineoplastic drugs. Cancer Treatment Reports, 62, 12 20032008 .
  66. 66. World Health Organization. 2009 Geneva: The Organization; 2009. Fact sheet 297 Cancer. Date of Access: March 28, 2011. Available from:
  67. 67. Young McCaughan. S.MaysM. Z.ArzolaS. M.YoderL. H.DramigaS. A.LeclercK. M.CatonJ. R.ShefflerR. L.NowlinM. U. 2003 Change in exercise tolerance, activity and sleep patterns, and quality of life in patients with cancer participating in a structured exercise program. Oncology Nursing Forum, 30, 3 441452 .
  68. 68. Young McCaughan. S. 2006 Exercise in the rehabilitation from cancer. Medsurg Nursing, 15, 6 384388 .

Written By

Karen Y. Wonders

Submitted: November 29th, 2010 Published: January 27th, 2012