Silver nanoparticles based membrane composites for wound management.
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These books synthesize perspectives of renowned scientists from the world’s most prestigious institutions - from Fukushima Renewable Energy Institute in Japan to Stanford University in the United States, including Columbia University (US), University of Sidney (AU), University of Miami (USA), Cardiff University (UK), and many others.
\\n\\nThis collaboration embodied the true essence of Open Access by simplifying the approach to OA publishing for Academic editors and authors who contributed their research and allowed the new research to be made available free and open to anyone anywhere in the world.
\\n\\nTo celebrate the 50 books published, we have gathered them at one location - just one click away, so that you can easily browse the subjects of your interest, download the content directly, share it or read online.
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IntechOpen and Knowledge Unlatched formed a partnership to support researchers working in engineering sciences by enabling an easier approach to publishing Open Access content. Using the Knowledge Unlatched crowdfunding model to raise the publishing costs through libraries around the world, Open Access Publishing Fee (OAPF) was not required from the authors.
\n\nInitially, the partnership supported engineering research, but it soon grew to include physical and life sciences, attracting more researchers to the advantages of Open Access publishing.
\n\n\n\nThese books synthesize perspectives of renowned scientists from the world’s most prestigious institutions - from Fukushima Renewable Energy Institute in Japan to Stanford University in the United States, including Columbia University (US), University of Sidney (AU), University of Miami (USA), Cardiff University (UK), and many others.
\n\nThis collaboration embodied the true essence of Open Access by simplifying the approach to OA publishing for Academic editors and authors who contributed their research and allowed the new research to be made available free and open to anyone anywhere in the world.
\n\nTo celebrate the 50 books published, we have gathered them at one location - just one click away, so that you can easily browse the subjects of your interest, download the content directly, share it or read online.
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\r\n\tVirtual Instrumentation revolutionized the engineer's and scientists’ activities in the field of measurements, monitoring, and testing. The main programing environment used for virtual instrument implementation in LabVIEW was developed by NI company. A very important aspect of education and engineering development is to use the right tool. In the current development, PCs and embedded systems are on a large scale use. Therefore, the programming of these could be a challenge for non-programming specialists. LabVIEW offers a solution for developing and implementing complex applications even for non-programming specialists. The LabVIEW libraries and add-ons offered by NI or the community allow educators and engineers to cover domains that otherwise would not be tangible for them. This book aims to collect original works and reviews concerning subjects such as correct technique programming approaches, simulation and modeling, systems control, remote control, IoT and IIoT, renewable energy, artificial intelligence, and combining LabVIEW with other programming languages.
\r\n\t
A wound is any type of injury which can be in the form of a cut, bruise or contusion caused by some external force. Open wounds are susceptible of getting infected by microorganisms like bacteria, virus or fungi if left unattended. Infected wounds pose a major challenge for healthcare system due to its direct relation with mortality and morbidity of the affected patients [1]. When a wound is infected it causes stress (physiological and psychological) and slows down the wound healing process and in some cases worsens the situation [2]. Approximately 2% of all hospitalized patients worldwide have a chronic wound, and older adult patients are at highest risk, because aging impairs the healing process [3, 4]. As many as 70% of these wounds recur, and 34% are accompanied by infection [5]. A survey by Medicare beneficiaries in 2018 stated that approximately 8.2 million individuals were having some kind of wounds, with or without infection and they estimated the treatment cost to be near about 28.1 billion to 96.8 billion dollars making it a big economic challenge as well [6]. Infectious wounds like surgical wounds, diabetic foot and ulcer are more problematic and are reported more frequently than other infectious wounds [7]. Silver since time memorial is used for its good antimicrobial potential due to its interference with the thiol group of the microbial membrane. It also increases production of reactive oxygen species with in the microbe resulting in damage of DNA and bacterial proteins [8]. Due to its broad spectrum antimicrobial activity, silver nanoparticles are getting a great attention especially in the form of dressing for the infected wounds. This chapter will throw light on the various applications and recent trends in the health care system for treatment of infectious wounds using silver nanoparticles.
In general, any form of breakage or harm to the surface of skin can be termed as a wound and broadly classified into two types i.e. acute wound and chronic wound. An acute wound is one in which the wound physiology tends to remain normal during the process of healing. Acute wounds are usually bites, minor burns, cuts and surgical wounds. It is seen that such kind of wounds heal within a predictable timespan depending upon the location, depth and type of wound. In case of chronic wounds the physiology of the wound is disturbed due to various endogenous mechanisms which results in damaging the integrity of the tissue. Examples of chronic wounds are ulcers, diabetic foot and pressure sores. These types of wounds aggravate by aging, malnutrition, diseases which results in immunosuppression within the patient like AIDS or in patients on immunosuppressant drugs [9, 10]. Wound is said to be infected when there is entry of a microbe from the breached skin, which slows down the healing process and results in appearance of signs and symptoms like pain, discoloration of the wounded area, edema, puss, abnormal smell, tenderness etc. [11]. Most of the hard to heal infected wounds are observed to possess biofilms in them [12]. Biofilms are surface linked microbial structural communities having sessile cells present in the matrix produced by the microbe itself, made of polysaccharides, deoxyribonucleic acid and other components which are an essential type of adaptation strategy for the survival of bacteria as it protects it from the harsh surroundings and several immune responses by the extracellular polymeric substance (EPS) [13]. Bacteria possessing biofilms has increased chance of gene transfer of antibiotic resistance gene to other bacterial species [14, 15]. Bacteria having biofilms are tough to treat even with higher doses as biofilms prevent antimicrobial agents to reach up to bacteria [16, 17]. Although there are many beliefs regarding the defensive mechanism of biofilms against the antimicrobial agents but till date its nature of defense is unknown [18].
Replacement of damaged tissue by newly produced tissue is termed as wound healing [19]. Skin (epidermis and dermis) acts as a protective layer against the harsh environment and when this barrier is breached a sequence of biochemical events takes place to repair the damage [19, 20]. The process of wound healing is generally described in four phases i.e. blood clotting, inflammation, tissue growth and tissue remodeling [21]. In the first phase with in some time platelets starts covering the area of the affected site. They release a particular chemical signal which promotes clotting resulting in activation of fibrin which produces a mesh to which platelets bind and forms a clot. This phase is also known as hemostasis [22, 23]. In second phase or inflammation stage clearing of debris and bacterial cells takes place via process of phagocytosis where white blood cells and macrophages engulf and destroys them [24]. In the next phase that is proliferation phase or tissue growth phase angiogenesis, collagen deposition, granulation tissue formation, epithelialization and wound contraction takes place [25]. At last the tissue enters the maturation or the remodeling phase in which collagen is realigned and the cells which are not needed are removed by apoptosis [26].
Since early times silver appeared in recorded history texts for its excellent antimicrobial action. The ancient Greek historian ‘Herodotus’ describes that at the times of war Persian kings among with his provisions used to take boiled water from silver jars [27, 28]. Raulin in 1869 was the first person who observed the antimicrobial activity of silver by observing that
Any small particle which ranges between 1 to 100 nanometers (10−9) in size is known as a nanoparticle. It cannot be detected with naked human eye and it exhibits different chemical and physical properties in comparison to their large material counterparts [36]. Among many inorganic nanoparticles, silver nanoparticles (AgNPs) have got researchers attention around the globe due its novel physical, chemical and biological properties as compared to their bulk form. They have particular chemical and physical properties like high electrical and thermal conductivity [37], surface enhanced Raman scattering effect [38], catalytic activity [39], chemical stability [40] and nonlinear optical behavior [41]. The above stated properties make it the material of choice to be used in electronics, and for medical use. Silver nanoparticles are also known for their antiviral, antibacterial and antifungal activity. Due to smaller size, surface area to volume ratio is increased which results in increase in the amount of atoms on the surface, that other forms. The net effect gives rise to unpredictable properties associated with nanoparticles [42]. Silver nanoparticles has shown proven antimicrobial activity in many in vivo and in vitro studies and have application in soaps, cosmetics, food packaging and wound dressing [43]. Due to epidermal keratin and phospholipids, and protein thiol groups, skin was thought to be impermeable to silver nanoparticles but some studies demonstrated, if any absorption beyond the stratum corneum [44, 45]. Silver wound dressings are in direct contact with damaged skin resulting in systemic absorption also associated with some toxicity [46].
In an average human concentration of silver in plasma is less than 2 μg/mL which is derived from inhalation of particulate matter and diet [44]. Silver can enter human body by inhalation, oral ingestion and dermal absorption [34]. Pinocytosis and endocytosis are believed to be two processes by which the silver nanoparticles may enter the body. It is seen that the particles that are of nanoscale penetrate much deeper than those of regular size leading to a novel delivery therapy [47, 48]. Till now exact mechanism of action of silver nanoparticles is not clear but several actions have been proposed by the scientists for its antimicrobial activity. Continual release of silver ion is considered to be the main reason for its antimicrobial activity [49]. Due to sulfur protein affinity and electrostatic attraction silver ions adhere to the wall of cells and cytoplasmic membrane which increases its permeability and penetrability into the cytoplasmic membrane leading to disruption of the bacterial cell wall [50]. When the silver ion enters the cell it can deactivate the respiratory enzymes and can generate reactive oxygen species [51]. Reactive oxygen species acts as a key component and a major reason for cell membrane disruption and DNA damage (by interacting with sulfur and phosphorus of DNA) causing problem in DNA replication, reproduction results in death of the microbes. Silver ions also inhibit the synthesis of proteins by denaturation of ribosomes and cause interruption the production of ATP [52]. After anchoring the surface of the cell silver nanoparticles gets accumulated in the pits of the cellular wall of microbe resulting in cell membrane denaturation [53]. Due to nanosize they easily penetrate cell membrane, leading to rupture of cell organelles and even lysis. They also affect the bacterial transduction process by interfering with the phosphorylation of protein substrates which can result in cell apoptosis and cell multiplication [53, 54]. Gram-negative bacterial strains are more sensitive towards the effect of silver nanoparticles because the cellular walls of these bacteria are narrower than the gram positive bacteria [55]. One drawback of silver nanoparticles is that they are not much effective in the case of bacteria having biofilms. Biofilms protects the membrane from both nanoparticles and silver ions by altering their transport due to its complicated structure [56]. The pathway of the nanoparticles penetration is highly obstructed if the size is grater that 50 nm [57]. It is also observed that adsorption and accumulation of the silver nanoparticles on the biofilm results in reduced diffusion of nanoparticles in bacteria [58].
A dressing is a sterile material applied to a wound to promote healing and protect the wound from further harm [59, 60]. It has been designed in such a way that it is in direct contact with the wound, as distinguished from a bandage, which is most often used to hold a dressing in place. Silver dressings are used for both types of wounds (acute and chronic) and when there is risk of high level of bio burden or local infection for example in the case of burns [61]. Silver dressings helps in reducing the bioburden in infected or colonized wounds and also acts as a barrier to reduce any further chance of infection [62].
There are four types of silver nanoparticles synthesis, namely chemical, irradiation, green and thermal. In chemical synthesis, two types of synthesis methods are used which are Brust-Schiffrin synthesis which is mainly used for golden nanoparticles and Turkevich method which is based on reduction of the boiling solution of silver salt with citrate salt solution [63, 64]. Irradiation synthesis is connected with radiation of precursors or intermediate products of reaction with electromagnetic radiation with different wavelengths [65, 66, 67]. In green synthesis plant, fungus or bacterial extract is mixed with silver ion usually silver nitrate, the bioactive molecules of extracts reduce silver ion to elementary silver and then it is precipitated in alcohol. Advantages of this synthesis are that cost involved in synthesis is low, environment friendly and plant extracts contain medicinal compounds which are used in conventional medicine [68, 69, 70, 71, 72, 73, 74, 75, 76, 77]. Thermal synthesis is based on the principle of thermal reduction of silver salt. After the synthesis of the silver nanoparticles, they are incorporated in membrane or composite material, nanofibers, hydrogels, etc. and are used as a wound dressing.
Membrane and composite material-immobilized nanoparticles can have many functions including antimicrobial activity. Silver nanoparticles incorporated in membranes like polyethersulfone, acetate cellulose, polydopamine-coated poly(ether imide) etc. showed significant antimicrobial activity against diverse range of microbes thus have capability to sterile wound environment and promote healing process [78], representative examples are summarized in Table 1.
Polymer used | Method of preparation of nanoparticles | Size (nm) | Result |
---|---|---|---|
Bacterial cellulose | Thermal method (thermal reduction at 80o C | 10–30 | Reduction seen in |
Chitin | Irradiation method, (gamma rays, 60Co) | 3–13 | Significant bactericidal effect (p < 0.01) [80] |
Bacterial cellulose | Green method (cellulose from | 50–150 | Strong activity against |
Chitosan, Polyvinyl alcohol, Curcumine | Green method (chitosan) | 16 | Significant effects against |
Chitosan and Chitin | Green method ( | 60–150 | Good healing activity [83] |
Konjac Glucomannan | Green method (egg white) | 8–32 | Accelerates wound healing and fibroblast growth promotion [84] |
Bacterial cellulose | Chemical method (NaBH4) | 3–17 | Inhibiton of growth of |
Chitin | Chemical method (sodium citrate) | 5 | Inhibiton of growth of |
Poly vinyl pyrrolidine chitosan | Chemical method (sodium citrate) | 10–30 | Reduces growth of |
Chitosan | Chemical method (NaBH4) | 15 | Facilitates cell proliferation and mitigate bacterial infection [88] |
Bacterial cellulose | Chemical method (NaBH4) | 5–14 | Inhibition of growth of |
Silver nanoparticles based membrane composites for wound management.
Powdered silver nanoparticles are used for incorporation into different types of clothing and dressings. Representative examples are summarized in Table 2.
Material used for preparation of clothing and dressings | Method of preparation of nanoparticles | Size (nm) | Result |
---|---|---|---|
Cotton fabrics | Chemical method (alkali solution of starch) | 22–24 | Inhibition of growth of |
Dressing material | Chemical method (NaBH4) | 4–24 | Reduction in wound inflammation and fibrogenic cytokines modulation [91] |
Cotton fabrics | Green method ( | 2 | Reduction of growth on |
Silver nanoparticles incorporated wound dressing | Green method ( | 200–800 | Effective wound healing activity [93] |
Silver nanoparticles incorporated clothing and dressings for wound management.
Nanofibers are emerged as an important structures with wide range of biological as well as physical applications like air filtration, immunoanalysis and as pseudo-enzymes etc. [81, 82, 83, 84, 94, 95]. Apart from that active research is also ongoing for utilization of silver nanoparticles incorporated nanofibers for wound management. Examples of nanofibers are given in Table 3.
Polymer used for preparation of nanofibers | Method of preparation of nanoparticles | Size (nm) | Result |
---|---|---|---|
Collagen | Chemical method (sodium citrate) | 25–55 | Accelerated wound healing [96] |
Poly vinyl pyrrolidine | Chemical method (N,N- DMF) | 3–5 | Effective antibacterial action [97] |
Poly methyl methacrylate-co-dopamine | Chemical method (Silver ion dipped in PMMDM) | <20 | Effective antibacterial and wound healing action [98] |
Plumbagine | Chemical method (PBG reduction) | 60 | High antibacterial activity [99] |
Gelatine | Chemical method (Silver nitrate reduced with gelatin powder) | 11–20 | High anti antibacterial activity against Gram positive bacteria [100] |
Poly ethylene oxide poly caprolactone | Chemical method (Silver nitrate reduced with PEO and DMF) | 13–17 | Good antibacterial potential [101] |
Alginate | Chemical method (NaBH4) | 5–17 | Reduces the inflammatory phase and increased epidermal thickness [102] |
Chitosan, glucose, Poly vinyl alcohol | Green method (chitosan, glucose) | 10–30 | Good antibacterial activity against gram negative bacteria [103] |
Poly galacturonic acid | Green method (PGA, HA) | 5–13 | Maximum wound epithelization and collagen deposition [104] |
Poly caprolactone | Green method ( | 5–20 | Excellent antibacterial activity against |
Poly vinyl alcohol | Irreadiation method | 23–24 | Significant antibacterial activity against |
Silver nanoparticles incorporated nanofibers for wound management.
Hydrogels have excellent capacity to absorb wound exudates and at the same time maintain the moisture in wound environment to ensure proper healing. Hydrogels form impermeable physical barrier on wound surface and prevent bacterial invasion (Figure 1) and apart from that hydrogels also showcased its tendency to absorb wide range of metals [59, 96, 107, 108]. Some silver nanoparticles incorporated hydrogels showed excellent wound healing activity as shown in Table 4.
Schematic layout of hydrogel membrane reducing bacterial invasion and accelerating wound healing process.
Polymer used for preparation of hydrogels | Method of preparation of nanoparticles | Size (nm) | Result |
---|---|---|---|
Poly acrylic acid and poly vinyl alcohol | Chemical method (NaBH4) | 2–3 | Significant antibacterial activity against |
Beta- chitin | Chemical method (sodium citrate) | 4–8 | It showed inhibitory effects on the bacteria growth [110] |
Chitosan | Green method (sericin and chitosan) | 240–970 | Bactericidal action [111] |
2-acrylamide-2-methylpropane sulphonic acid sodium salt | Irradiation method (UV radiation) | — | Used as a burn wound dressing due to its good antibacterial activity [112] |
Poly vinyl alcohol | Irradiation method (UV radiation, gamma rays 60Co) | 90 | Antimicrobial activity against |
Collagen | Thermal method (reduction at 40°C | 5–14 | Antimicrobial activity against |
Carboxymethylcellulose | Thermal method (reduction at 70–100°C | 7–21 | Removes the exudates and prevents wound maceration [115] |
Silver nanoparticles incorporated hydrogels for wound management.
Silver nanoparticles functionalized wound dressings have significant antimicrobial activity and provide faster and effective tissue repair thus they are widely explored for wound healing activity. Beside this they are far away from clinical practice as well as commercialization. More rigorous preclinical investigations are still required to validate their capability for tissue regeneration. Apart from that work is also needed to be done on industrial scale up techniques for commercialization.
Nanomaterial’s now a days representing potential ways for combating microbial related diseases and disorders. Wounds especially chronic ones burdened with resistant microbes are posing serious challenge to healthcare system. For that purpose silver nanoparticles impregnated wound dressing due to their excellent antimicrobial potential are not less than a boon. Along with sterilization they are proven to fasten tissue repair in wounds. Presently more rigorous efforts are needed in their preclinical investigations to evaluate their efficacy verses safety ratio. They have capability to become potential wound dressing of future.
The authors are also thankful to Guru Nanak Dev University, Amritsar for providing various facilities to carry out the work.
The authors declare no conflict of interest.
This is a brief overview of the main steps involved in publishing with IntechOpen Compacts, Monographs and Edited Books. Once you submit your proposal you will be appointed a Author Service Manager who will be your single point of contact and lead you through all the described steps below.
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\n\nAt this step you will also be asked to accept the Copyright Agreement.
\n\n5. LANGUAGE COPYEDITING, TECHNICAL EDITING AND TYPESET PROOF
\n\nYour manuscript will be sent to Straive, a leader in content solution services, for language copyediting. You will then receive a typeset proof formatted in XML and available online in HTML and PDF to proofread and check for completeness. The first typeset proof of your manuscript is usually available 10 days after its original submission.
\n\nAfter we receive your proof corrections and a final typeset of the manuscript is approved, your manuscript is sent to our in house DTP department for technical formatting and online publication preparation.
\n\nAdditionally, you will be asked to provide a profile picture (face or chest-up portrait photograph) and a short summary of the book which is required for the book cover design.
\n\n6. INVOICE PAYMENT
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\n\n7. ONLINE PUBLICATION, PRINT AND DELIVERY OF THE BOOK
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\n\nIf you feel that IntechOpen Compacts, Monographs or Edited Books are the right publishing format for your work, please fill out the publishing proposal form. For any specific queries related to the publishing process, or IntechOpen Compacts, Monographs & Edited Books in general, please contact us at book.department@intechopen.com
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Due to rapid depletion of agricultural areas and soil quality by means of ever-increasing population and an excessive addition of chemical fertilizers, a rehabilitated attention is a need of the hour to maintain sustainable approaches in agricultural crop production. Biochar is the solid, carbon-rich material obtained by pyrolysis using different biomasses. It has been widely documented in previous studies that, the crop growth and yield can be increased by using biochar. This chapter exclusively summarizes the properties of biochar, its interaction with soil microflora, and its role in plant growth promotion when added to the soil.",book:{id:"7305",slug:"biochar-an-imperative-amendment-for-soil-and-the-environment",title:"Biochar",fullTitle:"Biochar - An Imperative Amendment for Soil and the Environment"},signatures:"Jyoti Rawat, Jyoti Saxena and Pankaj Sanwal",authors:null},{id:"46355",doi:"10.5772/57469",title:"Phytoremediation of Soils Contaminated with Metals and Metalloids at Mining Areas: Potential of Native Flora",slug:"phytoremediation-of-soils-contaminated-with-metals-and-metalloids-at-mining-areas-potential-of-nativ",totalDownloads:8598,totalCrossrefCites:14,totalDimensionsCites:87,abstract:null,book:{id:"3854",slug:"environmental-risk-assessment-of-soil-contamination",title:"Environmental Risk Assessment of Soil Contamination",fullTitle:"Environmental Risk Assessment of Soil Contamination"},signatures:"Paulo J.C. Favas, João Pratas, Mayank Varun, Rohan D’Souza and\nManoj S. Paul",authors:[{id:"169746",title:"Dr.",name:"Paulo",middleName:null,surname:"Favas",slug:"paulo-favas",fullName:"Paulo Favas"},{id:"169747",title:"Dr.",name:"Manoj",middleName:"Stephen",surname:"Paul",slug:"manoj-paul",fullName:"Manoj Paul"},{id:"169952",title:"Dr.",name:"Joao",middleName:null,surname:"Pratas",slug:"joao-pratas",fullName:"Joao Pratas"},{id:"169953",title:"Dr.",name:"Mayank",middleName:null,surname:"Varun",slug:"mayank-varun",fullName:"Mayank Varun"},{id:"169954",title:"Dr.",name:"Rohan",middleName:null,surname:"D'Souza",slug:"rohan-d'souza",fullName:"Rohan D'Souza"}]},{id:"61845",doi:"10.5772/intechopen.77987",title:"Montmorillonite: An Introduction to Properties and Utilization",slug:"montmorillonite-an-introduction-to-properties-and-utilization",totalDownloads:5508,totalCrossrefCites:44,totalDimensionsCites:78,abstract:"Clay mineral is an important material available in nature. With an increasing understanding of clay structure, montmorillonite is realized viable for an enhanced performance in a variety of materials and products in the areas of catalysis, food additive, antibacterial function, polymer, sorbent, etc. Significant development in the use and application of montmorillonite is seen in recent time. This chapter provides an overview of montmorillonite, structure, and properties and particularly discusses its recent utilization in important materials. Montmorillonite is introduced in terms of its natural sources, chemical structure, physical and chemical properties, and functional utilization. The important physical and chemical properties are summarized as particle and layered structure, molecular structure and cation exchange effect, barrier property, and water sorption. This is followed by the important functional utilizations of montmorillonite based on the effects of its chemical structure. The important functional utilization of montmorillonite includes food additive for health and stamina, for antibacterial activity against tooth and gum decay, as sorbent for nonionic, anionic, and cationic dyes, and the use as catalyst in organic synthesis. The environment concerns, to date, do not indicate the adversity for particles used as additive. Studies will be useful which are clearly based on any montmorillonite structure to describe environmental effects.",book:{id:"6561",slug:"current-topics-in-the-utilization-of-clay-in-industrial-and-medical-applications",title:"Current Topics in the Utilization of Clay in Industrial and Medical Applications",fullTitle:"Current Topics in the Utilization of Clay in Industrial and Medical Applications"},signatures:"Faheem Uddin",authors:[{id:"228107",title:"Prof.",name:"Faheem",middleName:null,surname:"Uddin",slug:"faheem-uddin",fullName:"Faheem Uddin"}]}],mostDownloadedChaptersLast30Days:[{id:"46032",title:"Soil Contamination, Risk Assessment and Remediation",slug:"soil-contamination-risk-assessment-and-remediation",totalDownloads:14013,totalCrossrefCites:22,totalDimensionsCites:62,abstract:null,book:{id:"3854",slug:"environmental-risk-assessment-of-soil-contamination",title:"Environmental Risk Assessment of Soil Contamination",fullTitle:"Environmental Risk Assessment of Soil Contamination"},signatures:"Muhammad Aqeel Ashraf, Mohd. Jamil Maah and Ismail Yusoff",authors:[{id:"25185",title:"Dr.",name:"Muhammad Aqeel",middleName:null,surname:"Ashraf",slug:"muhammad-aqeel-ashraf",fullName:"Muhammad Aqeel Ashraf"},{id:"101988",title:"Dr.",name:"Ismail",middleName:null,surname:"Yusoff",slug:"ismail-yusoff",fullName:"Ismail Yusoff"},{id:"169931",title:"Prof.",name:"Mohd Jamil",middleName:null,surname:"Maah",slug:"mohd-jamil-maah",fullName:"Mohd Jamil Maah"},{id:"169932",title:"Dr.",name:"Ng Tham",middleName:null,surname:"Fatt",slug:"ng-tham-fatt",fullName:"Ng Tham Fatt"}]},{id:"71931",title:"Open Pit Mining",slug:"open-pit-mining",totalDownloads:1744,totalCrossrefCites:1,totalDimensionsCites:1,abstract:"Open pit mining method is one of the surface mining methods that has a traditional cone-shaped excavation and is usually employed to exploit a near-surface, nonselective and low-grade zones deposits. It often results in high productivity and requires large capital investments, low operating costs, and good safety conditions. The main topics that will be discussed in this chapter will include an introduction into the general features of open pit mining, ore body characteristics and configurations, stripping ratios and stripping overburden methods, mine elements and parameters, open pit operation cycle, pit slope angle, stability of mine slopes, types of highwall failures, mine closure and reclamation, and different variants of surface mining methods including opencast mining, mountainous mining, and artisan mining.",book:{id:"8620",slug:"mining-techniques-past-present-and-future",title:"Mining Techniques",fullTitle:"Mining Techniques - Past, Present and Future"},signatures:"Awwad H. Altiti, Rami O. Alrawashdeh and Hani M. Alnawafleh",authors:[{id:"313182",title:"Prof.",name:"Rami",middleName:null,surname:"Alrawashdeh",slug:"rami-alrawashdeh",fullName:"Rami Alrawashdeh"},{id:"313522",title:"Dr.",name:"Awwad",middleName:null,surname:"Altiti",slug:"awwad-altiti",fullName:"Awwad Altiti"},{id:"313523",title:"Prof.",name:"Hani",middleName:null,surname:"Alnawafleh",slug:"hani-alnawafleh",fullName:"Hani Alnawafleh"}]},{id:"64027",title:"Stages of a Integrated Geothermal Project",slug:"stages-of-a-integrated-geothermal-project",totalDownloads:4497,totalCrossrefCites:3,totalDimensionsCites:4,abstract:"A geothermal project constitutes two big stages: the exploration and the exploitation. Each one has a single task whose results allow defining the feasibility of a geothermal project, until achieving the construction and operation stage of the power generation plant. The first stage contains the area recognition, its limitation to the target, and elimination of external factors until defining a geothermal zone with characteristics to be commercially exploited. The main studies and analysis that can be applied during the exploration stage are listed, and the major indicator to continue with the project or suspend is the prefeasibility report. The major risks in the exploration stage are due to studies that are carried out on the surface; at this stage, the costs can be considered low. The main results of the exploration are the selection of sites to drill three or four initial wells. Each well provides a direct overview of the reservoir: depth, production thicknesses, thermodynamic parameters, and production characteristics. The drilling of three to four exploratory wells is recommended, as far as there is certainty of the feasibility of the project, and the development of the field begins with drilling of sufficient wells to feed the plant. In this stage, the cost increases, but the risks decrease.",book:{id:"7504",slug:"renewable-geothermal-energy-explorations",title:"Renewable Geothermal Energy Explorations",fullTitle:"Renewable Geothermal Energy Explorations"},signatures:"Alfonso Aragón-Aguilar, Georgina Izquierdo-Montalvo,\nDaniel Octavio Aragón-Gaspar and Denise N. Barreto-Rivera",authors:[{id:"258358",title:"Dr.",name:"Alfonso",middleName:null,surname:"Aragón-Aguilar",slug:"alfonso-aragon-aguilar",fullName:"Alfonso Aragón-Aguilar"}]},{id:"65070",title:"Biochar: A Sustainable Approach for Improving Plant Growth and Soil Properties",slug:"biochar-a-sustainable-approach-for-improving-plant-growth-and-soil-properties",totalDownloads:6959,totalCrossrefCites:60,totalDimensionsCites:99,abstract:"Soil is the most important source and an abode for many nutrients and microflora. Due to rapid depletion of agricultural areas and soil quality by means of ever-increasing population and an excessive addition of chemical fertilizers, a rehabilitated attention is a need of the hour to maintain sustainable approaches in agricultural crop production. Biochar is the solid, carbon-rich material obtained by pyrolysis using different biomasses. It has been widely documented in previous studies that, the crop growth and yield can be increased by using biochar. This chapter exclusively summarizes the properties of biochar, its interaction with soil microflora, and its role in plant growth promotion when added to the soil.",book:{id:"7305",slug:"biochar-an-imperative-amendment-for-soil-and-the-environment",title:"Biochar",fullTitle:"Biochar - An Imperative Amendment for Soil and the Environment"},signatures:"Jyoti Rawat, Jyoti Saxena and Pankaj Sanwal",authors:null},{id:"39170",title:"Study of Impacts of Global Warming on Climate Change: Rise in Sea Level and Disaster Frequency",slug:"study-of-impacts-of-global-warming-on-climate-change-rise-in-sea-level-and-disaster-frequency",totalDownloads:6702,totalCrossrefCites:14,totalDimensionsCites:32,abstract:null,book:{id:"2206",slug:"global-warming-impacts-and-future-perspective",title:"Global Warming",fullTitle:"Global Warming - Impacts and Future Perspective"},signatures:"Bharat Raj Singh and Onkar Singh",authors:[{id:"26093",title:"Dr.",name:"Bharat Raj",middleName:null,surname:"Singh",slug:"bharat-raj-singh",fullName:"Bharat Raj Singh"},{id:"118426",title:"Prof.",name:"Onkar",middleName:null,surname:"Singh",slug:"onkar-singh",fullName:"Onkar Singh"}]}],onlineFirstChaptersFilter:{topicId:"10",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"82823",title:"The Metropolitan Transformation of Ioannina City from 1940 to 2015",slug:"the-metropolitan-transformation-of-ioannina-city-from-1940-to-2015",totalDownloads:5,totalDimensionsCites:0,doi:"10.5772/intechopen.105884",abstract:"The chapter presents the urban and regional changes in the city of Ioannina, Greece. This city is located in the periphery of Epirus, which is in the western Balkans, Eastern Europe. The chapter examines, with the tools of aerial photos and QGIS software, the spatial transformation of Ioannina city from 1940 to 2015. Map science is a field through which the users could observe and compare maps from past to future. The plans and the planning were formed under the values, standards, and fundamentals of the mosaic of politics, good practices, urban rules, and citizen level. The urban space has already changed until nowadays. The chapter examines the reasons for urban politics and social–economic moments that became the epitome of these urban and regional changes. The results show the comparative spatial study from each historical period.",book:{id:"11488",title:"GIS and Spatial Analysis",coverURL:"https://cdn.intechopen.com/books/images_new/11488.jpg"},signatures:"Efthymios-Spyridon Georgiou"},{id:"83032",title:"Introductory Chapter: Solar Photovoltaic Energy",slug:"introductory-chapter-solar-photovoltaic-energy",totalDownloads:5,totalDimensionsCites:0,doi:"10.5772/intechopen.106259",abstract:null,book:{id:"9862",title:"Solar Radiation - Measurements, Modeling and Forecasting for Photovoltaic Solar Energy Applications",coverURL:"https://cdn.intechopen.com/books/images_new/9862.jpg"},signatures:"Mohammadreza Aghaei, Amir Nedaei, Aref Eskandari and Jafar Milimonfared"},{id:"82963",title:"Evolution of Radio Source Components and the Quasar/Galaxy Unification Scheme",slug:"evolution-of-radio-source-components-and-the-quasar-galaxy-unification-scheme",totalDownloads:4,totalDimensionsCites:0,doi:"10.5772/intechopen.106244",abstract:"In this work, a theoretical model is developed for explanation of temporal evolution of extragalactic radio sources via beaming, orientation effects and asymmetries. Equation of the form D≈P±q1+z−m is used to account for the D ∼ P/z relation. Also, D≈D01+z−1+z1+z2 accounted properly for Ω0=1 cosmology than the Ω0=0 counterpart in linear size versus redshift of radio sources. Similarly, D=Dc1∓lnPPc1/2 model explained redshift-luminosity relationship of extragalactic radio sources. The results from the regression analyses are q = +0.003 (r = 0.04) for sources with z < 1 and q = −1.59 (r = −0.6) for all z≥1 sources. A critical linear size, Dc of 316kpc which matches the maximum theoretical linear size, Dmax of 0.15D0 at a critical redshift zc∼1 and a critical luminosity Pc=26.33WHz−1 are obtained. The indication of all these results is that the linear size of radio sources evolves up to a certain limit in D–P plane and thereafter decreases with increasing luminosity as predicted in this work.",book:{id:"11737",title:"Astronomy",coverURL:"https://cdn.intechopen.com/books/images_new/11737.jpg"},signatures:"Costecia Ifeoma Onah, Augustine A. Ubachukwu and Finbarr C. Odo"},{id:"82981",title:"Wood Quality and Pulping Process Efficiency of Elite Eucalyptus spp. Clones Field-Grown under Seasonal Drought Stress",slug:"wood-quality-and-pulping-process-efficiency-of-elite-eucalyptus-spp-clones-field-grown-under-seasona",totalDownloads:8,totalDimensionsCites:0,doi:"10.5772/intechopen.106341",abstract:"The objective of the present study is to evaluate the wood quality of five elite Eucalyptus spp. clones at 4 years of age from a clonal test installed in a region of seasonal drought stress in central-western Brazil focusing on pulp production. A total of 25 trees were systematically felled and disks and logs were obtained along the trunk. Wooden disks were used for density and fiber analyses and the logs were converted into chips for application in the pulping process. For the denser genotype, clone D (E. grandis x E. urophylla x Eucalyptus tereticornis), a thicker cell wall associated to thinner fibers results in a negative effect on the fiber quality. In contrast, clone B (Eucalyptus pellita x E. grandis), which has relatively inferior pulping performance, displayed the lowest wood density associated to wider lumen and fibers. The best growth performances in response to acclimatization and adaptation to the site strongly influences the pulp productivity, which is identified as the parameter of greatest variance between genotypes, and highlighting clone E (E. grandis x E. urophylla).",book:{id:"11840",title:"Arid Environment - Perspectives, Challenges and Management",coverURL:"https://cdn.intechopen.com/books/images_new/11840.jpg"},signatures:"Deborah Rodrigues de Souza Santos, Camila Sarto, Rafael Fernandes dos Santos, Júlia Lôbo Ribeiro Anciotti Gil, Carlos de Melo e Silva-Neto, Regina Maria Gomes, Evandro Novaes, Carlos Roberto Sette-Junior, Mario Tomazello-Filho, Rafael Tassinari Resende and Matheus Peres Chagas"},{id:"82957",title:"The Socio-Economic Factors of the Covid-19 Pandemic in Turkey: A Spatial Perspective",slug:"the-socio-economic-factors-of-the-covid-19-pandemic-in-turkey-a-spatial-perspective",totalDownloads:9,totalDimensionsCites:0,doi:"10.5772/intechopen.106048",abstract:"This study investigates the role of various socioeconomic determinants and vaccination rates in the spread of Covid-19 in a spatial setting in Turkey. For this aim, we employ the 41 sub-indicators of Life Index in Provinces data provided by the Turkish Statistical Institute which is obtained based on the Organization for Economic Cooperation and Development (OECD) Better Life Index approach. Our results indicate no global interactions in the transmission process of the disease among Turkish provinces. This means that the infection burden in the neighboring province does not significantly affect the infection burden of a given state. Yet, we show that vaccination rates and the median age of a neighboring province significantly affect the number of total cases in a given province. We find that as the vaccination rates of a neighboring province rise, the number of total cases in a given province also increases. This finding can be attributed to the “neighbor–reliant immunity” concept. It seems that people with vaccine hesitancy toward Covid-19 feel safer without a vaccine when their neighbors are mostly vaccinated. Last, people with a higher satisfaction rate with their health status are more likely to catch the disease due to underestimation of negative consequences.",book:{id:"11488",title:"GIS and Spatial Analysis",coverURL:"https://cdn.intechopen.com/books/images_new/11488.jpg"},signatures:"Sevgi Eda Tuzcu and Esra Satıcı"},{id:"82652",title:"Intra-Plate Dynamics and Active Tectonic Zones of the Indian Plate",slug:"intra-plate-dynamics-and-active-tectonic-zones-of-the-indian-plate",totalDownloads:7,totalDimensionsCites:0,doi:"10.5772/intechopen.105647",abstract:"The tectonic framework of the Indian Plate started to evolve since the break-up of Gondwanaland in the Late Triassic. It evolved mainly during the time between its separation from the African plate in the Early-Cretaceous and its collision with the Eurasian plate on the north in Late-Middle Eocene and with the Burmese plate in the northeast in Late-Oligocene. Present active tectonic zones, responsible for earthquake generation, were created by the collision pattern and subsequent plate motion. Continued subduction and plate motion due to ridge push and slab pull are responsible for the activation of primordial faults in the inherent structural fabric of the craton depending on the related stress field. Major tectonic zones of the Indian continental plate are related to the collision fronts and the reactivated intra-cratonic faults along the resurgent paleo-sutures between the proto-cratons. Major Tectonic Zones (TZ) are Himalayan TZ, Assam-Arakan TZ, Baluchistan- Karakoram TZ, Andaman-Nicobar TZ, and Stable Continental Region (SCR) earthquake zone. The structure of the continental margins developed during the break-up of Gondwana continental fragments. Western margin evolved during the sequential separation of Africa, Madagascar, and Seychelles since the Late-Triassic to Late Cretaceous time. The Eastern margin structure evolved during the separation of Antarctica in Mid Cretaceous. The orogenic belt circumscribing the northern margin of Indian plate is highly tectonised as the subduction of the plate continues due to northerly push from the Carlsberg Ridge in the SW and slab-pull towards northeast and east along the orogenic and island arc fronts in the NE. This stress pattern induced an anticlockwise rotatory plate motion. The back thrust from the collision front in the direction opposite to the ridge push put the plate under an overall compressive stress. This stress pattern and the plate motion are responsible for the reactivation of the major intra-cratonic faults. While the tectonised orogenic belts are the zones for earthquake nucleation, the reactivated faults are also the strained mega shear zones across the plate for earthquake generation in SCR. These faults trending WNW-ESE are apparently the transform faults that extend across the continent from Carlsberg ridge in the west to the collision zones in the northeast. As such, they are described here as the ‘trans-continental transform faults’. Three such major fault zones from north to south are (i) North Kathiawar fault - Great Boundary fault (along the Aravalli belt) zone, (ii) South Saurashtra fault (extension of Narmada fault) – SONATA-Dauki-Naga fault zone, and (iii) Tellichery-Cauvery-Eastern Ghat-T3-Hail Hakalula-Naga thrust zone. All these trans-continental faults, which are mega-shear zones, are traceable from western offshore to the northeastern orogenic belts along mega tectonic lineaments across the continent. The neotectonic movements along these faults, their relative motion, and displacement are the architect of the present geomorphic pattern and shape of the Indian craton. The overall compressive stress is responsible for strain build-up within these fault zones and consequent earthquake nucleation. The mid-continental Sonata-Dauki shear zone follows the Central Indian Suture Zone between Bundelkhand Proto Continent (BPC) and Deccan Proto Continent (DPC). With the reactivation of this shear zone, the two proto-cratonic blocks are subjected to relative movement as the plate rotates anticlockwise. The kinematics of these movements and their implications are discussed here with a special reference to the recent 2001 Bhuj earthquake.",book:{id:"11490",title:"Advances in Plate Tectonics",coverURL:"https://cdn.intechopen.com/books/images_new/11490.jpg"},signatures:"Sanjib K. Biswas and Gaurav D. Chauhan"}],onlineFirstChaptersTotal:134},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:0,limit:8,total:null},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:108,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:330,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:9,numberOfPublishedChapters:141,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:124,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:22,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:11,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. This Biochemistry Series will address the current research on biomolecules and the emerging trends with great promise.",coverUrl:"https://cdn.intechopen.com/series/covers/11.jpg",latestPublicationDate:"August 2nd, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:33,editor:{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",slug:"miroslav-blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:4,paginationItems:[{id:"14",title:"Cell and Molecular Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",isOpenForSubmission:!0,editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",slug:"rosa-maria-martinez-espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",biography:"Dr. Rosa María Martínez-Espinosa has been a Spanish Full Professor since 2020 (Biochemistry and Molecular Biology) and is currently Vice-President of International Relations and Cooperation development and leader of the research group 'Applied Biochemistry” (University of Alicante, Spain). Other positions she has held at the university include Vice-Dean of Master Programs, Vice-Dean of the Degree in Biology and Vice-Dean for Mobility and Enterprise and Engagement at the Faculty of Science (University of Alicante). She received her Bachelor in Biology in 1998 (University of Alicante) and her PhD in 2003 (Biochemistry, University of Alicante). She undertook post-doctoral research at the University of East Anglia (Norwich, U.K. 2004-2005; 2007-2008).\nHer multidisciplinary research focuses on investigating archaea and their potential applications in biotechnology. She has an H-index of 21. She has authored one patent and has published more than 70 indexed papers and around 60 book chapters.\nShe has contributed to more than 150 national and international meetings during the last 15 years. Her research interests include archaea metabolism, enzymes purification and characterization, gene regulation, carotenoids and bioplastics production, antioxidant\ncompounds, waste water treatments, and brines bioremediation.\nRosa María’s other roles include editorial board member for several journals related\nto biochemistry, reviewer for more than 60 journals (biochemistry, molecular biology, biotechnology, chemistry and microbiology) and president of several organizing committees in international meetings related to the N-cycle or respiratory processes.",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"15",title:"Chemical Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",isOpenForSubmission:!0,editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",slug:"sukru-beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",biography:"Dr. Şükrü Beydemir obtained a BSc in Chemistry in 1995 from Yüzüncü Yıl University, MSc in Biochemistry in 1998, and PhD in Biochemistry in 2002 from Atatürk University, Turkey. 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He is a member of the Turkish Biochemical Society, American Chemical Society, and German Genetics society. Dr. Ekinci published around ninety scientific papers, reviews and book chapters, and presented several conferences to scientists. He has received numerous publication awards from several scientific councils. 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He worked on the structure-function relationships of glycoconjugates and his main project was the investigations on the biological roles of the de-N-glycosylation enzymes (Endo-N-acetyl-β-D-glucosaminidase and peptide-N4-(N-acetyl-β-glucosaminyl) asparagine amidase). From 2002 he contributes to the understanding of the Blood-brain barrier functioning using proteomics approaches. He has published more than 70 papers. 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Since then, he has been working as an Adjunct Professor in the same Department at the University of Pavia. His research activity during the first years was primarily focused on the purification and structural characterization of enzymes from animal and plant sources. During this period, Prof. Iadarola familiarized himself with the conventional techniques used in column chromatography, spectrophotometry, manual Edman degradation, and electrophoresis). Since 1995, he has been working on: i) the determination in biological fluids (serum, urine, bronchoalveolar lavage, sputum) of proteolytic activities involved in the degradation processes of connective tissue matrix, and ii) on the identification of biological markers of lung diseases. 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He has both an MS and Ph.D. in Biomedical Engineering. He was previously a research scientist at the University of California Los Angeles (UCLA) and visiting professor and researcher at the University of North Dakota. He is currently working in artificial intelligence and its applications in medical signal processing. In addition, he is using digital signal processing in medical imaging and speech processing. Dr. Asadpour has developed brain-computer interfacing algorithms and has published books, book chapters, and several journal and conference papers in this field and other areas of intelligent signal processing. He has also designed medical devices, including a laser Doppler monitoring system.",institutionString:"Kaiser Permanente Southern California",institution:null},{id:"169608",title:"Prof.",name:"Marian",middleName:null,surname:"Găiceanu",slug:"marian-gaiceanu",fullName:"Marian Găiceanu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/169608/images/system/169608.png",biography:"Prof. Dr. Marian Gaiceanu graduated from the Naval and Electrical Engineering Faculty, Dunarea de Jos University of Galati, Romania, in 1997. He received a Ph.D. (Magna Cum Laude) in Electrical Engineering in 2002. Since 2017, Dr. Gaiceanu has been a Ph.D. supervisor for students in Electrical Engineering. He has been employed at Dunarea de Jos University of Galati since 1996, where he is currently a professor. Dr. Gaiceanu is a member of the National Council for Attesting Titles, Diplomas and Certificates, an expert of the Executive Agency for Higher Education, Research Funding, and a member of the Senate of the Dunarea de Jos University of Galati. He has been the head of the Integrated Energy Conversion Systems and Advanced Control of Complex Processes Research Center, Romania, since 2016. He has conducted several projects in power converter systems for electrical drives, power quality, PEM and SOFC fuel cell power converters for utilities, electric vehicles, and marine applications with the Department of Regulation and Control, SIEI S.pA. (2002–2004) and the Polytechnic University of Turin, Italy (2002–2004, 2006–2007). He is a member of the Institute of Electrical and Electronics Engineers (IEEE) and cofounder-member of the IEEE Power Electronics Romanian Chapter. He is a guest editor at Energies and an academic book editor for IntechOpen. He is also a member of the editorial boards of the Journal of Electrical Engineering, Electronics, Control and Computer Science and Sustainability. Dr. Gaiceanu has been General Chairman of the IEEE International Symposium on Electrical and Electronics Engineering in the last six editions.",institutionString:'"Dunarea de Jos" University of Galati',institution:{name:'"Dunarea de Jos" University of Galati',country:{name:"Romania"}}},{id:"4519",title:"Prof.",name:"Jaydip",middleName:null,surname:"Sen",slug:"jaydip-sen",fullName:"Jaydip Sen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/4519/images/system/4519.jpeg",biography:"Jaydip Sen is associated with Praxis Business School, Kolkata, India, as a professor in the Department of Data Science. His research areas include security and privacy issues in computing and communication, intrusion detection systems, machine learning, deep learning, and artificial intelligence in the financial domain. He has more than 200 publications in reputed international journals, refereed conference proceedings, and 20 book chapters in books published by internationally renowned publishing houses, such as Springer, CRC press, IGI Global, etc. Currently, he is serving on the editorial board of the prestigious journal Frontiers in Communications and Networks and in the technical program committees of a number of high-ranked international conferences organized by the IEEE, USA, and the ACM, USA. He has been listed among the top 2% of scientists in the world for the last three consecutive years, 2019 to 2021 as per studies conducted by the Stanford University, USA.",institutionString:"Praxis Business School",institution:null},{id:"320071",title:"Dr.",name:"Sidra",middleName:null,surname:"Mehtab",slug:"sidra-mehtab",fullName:"Sidra Mehtab",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00002v6KHoQAM/Profile_Picture_1584512086360",biography:"Sidra Mehtab has completed her BS with honors in Physics from Calcutta University, India in 2018. She has done MS in Data Science and Analytics from Maulana Abul Kalam Azad University of Technology (MAKAUT), Kolkata, India in 2020. Her research areas include Econometrics, Time Series Analysis, Machine Learning, Deep Learning, Artificial Intelligence, and Computer and Network Security with a particular focus on Cyber Security Analytics. Ms. Mehtab has published seven papers in international conferences and one of her papers has been accepted for publication in a reputable international journal. She has won the best paper awards in two prestigious international conferences – BAICONF 2019, and ICADCML 2021, organized in the Indian Institute of Management, Bangalore, India in December 2019, and SOA University, Bhubaneswar, India in January 2021. Besides, Ms. Mehtab has also published two book chapters in two books. Seven of her book chapters will be published in a volume shortly in 2021 by Cambridge Scholars’ Press, UK. Currently, she is working as the joint editor of two edited volumes on Time Series Analysis and Forecasting to be published in the first half of 2021 by an international house. Currently, she is working as a Data Scientist with an MNC in Delhi, India.",institutionString:"NSHM College of Management and Technology",institution:{name:"Association for Computing Machinery",country:{name:"United States of America"}}},{id:"226240",title:"Dr.",name:"Andri Irfan",middleName:null,surname:"Rifai",slug:"andri-irfan-rifai",fullName:"Andri Irfan Rifai",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/226240/images/7412_n.jpg",biography:"Andri IRFAN is a Senior Lecturer of Civil Engineering and Planning. He completed the PhD at the Universitas Indonesia & Universidade do Minho with Sandwich Program Scholarship from the Directorate General of Higher Education and LPDP scholarship. He has been teaching for more than 19 years and much active to applied his knowledge in the project construction in Indonesia. His research interest ranges from pavement management system to advanced data mining techniques for transportation engineering. He has published more than 50 papers in journals and 2 books.",institutionString:null,institution:{name:"Universitas Internasional Batam",country:{name:"Indonesia"}}},{id:"314576",title:"Dr.",name:"Ibai",middleName:null,surname:"Laña",slug:"ibai-lana",fullName:"Ibai Laña",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/314576/images/system/314576.jpg",biography:"Dr. Ibai Laña works at TECNALIA as a data analyst. He received his Ph.D. in Artificial Intelligence from the University of the Basque Country (UPV/EHU), Spain, in 2018. He is currently a senior researcher at TECNALIA. His research interests fall within the intersection of intelligent transportation systems, machine learning, traffic data analysis, and data science. He has dealt with urban traffic forecasting problems, applying machine learning models and evolutionary algorithms. He has experience in origin-destination matrix estimation or point of interest and trajectory detection. Working with large volumes of data has given him a good command of big data processing tools and NoSQL databases. He has also been a visiting scholar at the Knowledge Engineering and Discovery Research Institute, Auckland University of Technology.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"314575",title:"Dr.",name:"Jesus",middleName:null,surname:"L. Lobo",slug:"jesus-l.-lobo",fullName:"Jesus L. Lobo",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/314575/images/system/314575.png",biography:"Dr. Jesús López is currently based in Bilbao (Spain) working at TECNALIA as Artificial Intelligence Research Scientist. In most cases, a project idea or a new research line needs to be investigated to see if it is good enough to take into production or to focus on it. That is exactly what he does, diving into Machine Learning algorithms and technologies to help TECNALIA to decide whether something is great in theory or will actually impact on the product or processes of its projects. So, he is expert at framing experiments, developing hypotheses, and proving whether they’re true or not, in order to investigate fundamental problems with a longer time horizon. He is also able to design and develop PoCs and system prototypes in simulation. He has participated in several national and internacional R&D projects.\n\nAs another relevant part of his everyday research work, he usually publishes his findings in reputed scientific refereed journals and international conferences, occasionally acting as reviewer and Programme Commitee member. Concretely, since 2018 he has published 9 JCR (8 Q1) journal papers, 9 conference papers (e.g. ECML PKDD 2021), and he has co-edited a book. He is also active in popular science writing data science stories for reputed blogs (KDNuggets, TowardsDataScience, Naukas). Besides, he has recently embarked on mentoring programmes as mentor, and has also worked as data science trainer.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"103779",title:"Prof.",name:"Yalcin",middleName:null,surname:"Isler",slug:"yalcin-isler",fullName:"Yalcin Isler",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRyQ8QAK/Profile_Picture_1628834958734",biography:"Yalcin Isler (1971 - Burdur / Turkey) received the B.Sc. degree in the Department of Electrical and Electronics Engineering from Anadolu University, Eskisehir, Turkey, in 1993, the M.Sc. degree from the Department of Electronics and Communication Engineering, Suleyman Demirel University, Isparta, Turkey, in 1996, the Ph.D. degree from the Department of Electrical and Electronics Engineering, Dokuz Eylul University, Izmir, Turkey, in 2009, and the Competence of Associate Professorship from the Turkish Interuniversity Council in 2019.\n\nHe was Lecturer at Burdur Vocational School in Suleyman Demirel University (1993-2000, Burdur / Turkey), Software Engineer (2000-2002, Izmir / Turkey), Research Assistant in Bulent Ecevit University (2002-2003, Zonguldak / Turkey), Research Assistant in Dokuz Eylul University (2003-2010, Izmir / Turkey), Assistant Professor at the Department of Electrical and Electronics Engineering in Bulent Ecevit University (2010-2012, Zonguldak / Turkey), Assistant Professor at the Department of Biomedical Engineering in Izmir Katip Celebi University (2012-2019, Izmir / Turkey). He is an Associate Professor at the Department of Biomedical Engineering at Izmir Katip Celebi University, Izmir / Turkey, since 2019. In addition to academics, he has also founded Islerya Medical and Information Technologies Company, Izmir / Turkey, since 2017.\n\nHis main research interests cover biomedical signal processing, pattern recognition, medical device design, programming, and embedded systems. He has many scientific papers and participated in several projects in these study fields. He was an IEEE Student Member (2009-2011) and IEEE Member (2011-2014) and has been IEEE Senior Member since 2014.",institutionString:null,institution:{name:"Izmir Kâtip Çelebi University",country:{name:"Turkey"}}},{id:"339677",title:"Dr.",name:"Mrinmoy",middleName:null,surname:"Roy",slug:"mrinmoy-roy",fullName:"Mrinmoy Roy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/339677/images/16768_n.jpg",biography:"An accomplished Sales & Marketing professional with 12 years of cross-functional experience in well-known organisations such as CIPLA, LUPIN, GLENMARK, ASTRAZENECA across different segment of Sales & Marketing, International Business, Institutional Business, Product Management, Strategic Marketing of HIV, Oncology, Derma, Respiratory, Anti-Diabetic, Nutraceutical & Stomatological Product Portfolio and Generic as well as Chronic Critical Care Portfolio. A First Class MBA in International Business & Strategic Marketing, B.Pharm, D.Pharm, Google Certified Digital Marketing Professional. Qualified PhD Candidate in Operations and Management with special focus on Artificial Intelligence and Machine Learning adoption, analysis and use in Healthcare, Hospital & Pharma Domain. Seasoned with diverse therapy area of Pharmaceutical Sales & Marketing ranging from generating revenue through generating prescriptions, launching new products, and making them big brands with continuous strategy execution at the Physician and Patients level. Moved from Sales to Marketing and Business Development for 3.5 years in South East Asian Market operating from Manila, Philippines. Came back to India and handled and developed Brands such as Gluconorm, Lupisulin, Supracal, Absolut Woman, Hemozink, Fabiflu (For COVID 19), and many more. In my previous assignment I used to develop and execute strategies on Sales & Marketing, Commercialization & Business Development for Institution and Corporate Hospital Business portfolio of Oncology Therapy Area for AstraZeneca Pharma India Ltd. Being a Research Scholar and Student of ‘Operations Research & Management: Artificial Intelligence’ I published several pioneer research papers and book chapters on the same in Internationally reputed journals and Books indexed in Scopus, Springer and Ei Compendex, Google Scholar etc. Currently, I am launching PGDM Pharmaceutical Management Program in IIHMR Bangalore and spearheading the course curriculum and structure of the same. I am interested in Collaboration for Healthcare Innovation, Pharma AI Innovation, Future trend in Marketing and Management with incubation on Healthcare, Healthcare IT startups, AI-ML Modelling and Healthcare Algorithm based training module development. I am also an affiliated member of the Institute of Management Consultant of India, looking forward to Healthcare, Healthcare IT and Innovation, Pharma and Hospital Management Consulting works.",institutionString:null,institution:{name:"Lovely Professional University",country:{name:"India"}}},{id:"310576",title:"Prof.",name:"Erick Giovani",middleName:null,surname:"Sperandio Nascimento",slug:"erick-giovani-sperandio-nascimento",fullName:"Erick Giovani Sperandio Nascimento",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0033Y00002pDKxDQAW/ProfilePicture%202022-06-20%2019%3A57%3A24.788",biography:"Prof. Erick Sperandio is the Lead Researcher and professor of Artificial Intelligence (AI) at SENAI CIMATEC, Bahia, Brazil, also working with Computational Modeling (CM) and HPC. He holds a PhD in Environmental Engineering in the area of Atmospheric Computational Modeling, a Master in Informatics in the field of Computational Intelligence and Graduated in Computer Science from UFES. He currently coordinates, leads and participates in R&D projects in the areas of AI, computational modeling and supercomputing applied to different areas such as Oil and Gas, Health, Advanced Manufacturing, Renewable Energies and Atmospheric Sciences, advising undergraduate, master's and doctoral students. He is the Lead Researcher at SENAI CIMATEC's Reference Center on Artificial Intelligence. In addition, he is a Certified Instructor and University Ambassador of the NVIDIA Deep Learning Institute (DLI) in the areas of Deep Learning, Computer Vision, Natural Language Processing and Recommender Systems, and Principal Investigator of the NVIDIA/CIMATEC AI Joint Lab, the first in Latin America within the NVIDIA AI Technology Center (NVAITC) worldwide program. He also works as a researcher at the Supercomputing Center for Industrial Innovation (CS2i) and at the SENAI Institute of Innovation for Automation (ISI Automação), both from SENAI CIMATEC. He is a member and vice-coordinator of the Basic Board of Scientific-Technological Advice and Evaluation, in the area of Innovation, of the Foundation for Research Support of the State of Bahia (FAPESB). He serves as Technology Transfer Coordinator and one of the Principal Investigators at the National Applied Research Center in Artificial Intelligence (CPA-IA) of SENAI CIMATEC, focusing on Industry, being one of the six CPA-IA in Brazil approved by MCTI / FAPESP / CGI.br. He also participates as one of the representatives of Brazil in the BRICS Innovation Collaboration Working Group on HPC, ICT and AI. He is the coordinator of the Work Group of the Axis 5 - Workforce and Training - of the Brazilian Strategy for Artificial Intelligence (EBIA), and member of the MCTI/EMBRAPII AI Innovation Network Training Committee. He is the coordinator, by SENAI CIMATEC, of the Artificial Intelligence Reference Network of the State of Bahia (REDE BAH.IA). He leads the working group of experts representing Brazil in the Global Partnership on Artificial Intelligence (GPAI), on the theme \"AI and the Pandemic Response\".",institutionString:"Manufacturing and Technology Integrated Campus – SENAI CIMATEC",institution:null},{id:"1063",title:"Prof.",name:"Constantin",middleName:null,surname:"Volosencu",slug:"constantin-volosencu",fullName:"Constantin Volosencu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/1063/images/system/1063.png",biography:"Prof. Dr. Constantin Voloşencu graduated as an engineer from\nPolitehnica University of Timișoara, Romania, where he also\nobtained a doctorate degree. He is currently a full professor in\nthe Department of Automation and Applied Informatics at the\nsame university. Dr. Voloşencu is the author of ten books, seven\nbook chapters, and more than 160 papers published in journals\nand conference proceedings. He has also edited twelve books and\nhas twenty-seven patents to his name. He is a manager of research grants, editor in\nchief and member of international journal editorial boards, a former plenary speaker, a member of scientific committees, and chair at international conferences. His\nresearch is in the fields of control systems, control of electric drives, fuzzy control\nsystems, neural network applications, fault detection and diagnosis, sensor network\napplications, monitoring of distributed parameter systems, and power ultrasound\napplications. He has developed automation equipment for machine tools, spooling\nmachines, high-power ultrasound processes, and more.",institutionString:'"Politechnica" University Timişoara',institution:null},{id:"221364",title:"Dr.",name:"Eneko",middleName:null,surname:"Osaba",slug:"eneko-osaba",fullName:"Eneko Osaba",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/221364/images/system/221364.jpg",biography:"Dr. Eneko Osaba works at TECNALIA as a senior researcher. He obtained his Ph.D. in Artificial Intelligence in 2015. He has participated in more than twenty-five local and European research projects, and in the publication of more than 130 papers. He has performed several stays at universities in the United Kingdom, Italy, and Malta. Dr. Osaba has served as a program committee member in more than forty international conferences and participated in organizing activities in more than ten international conferences. He is a member of the editorial board of the International Journal of Artificial Intelligence, Data in Brief, and Journal of Advanced Transportation. He is also a guest editor for the Journal of Computational Science, Neurocomputing, Swarm, and Evolutionary Computation and IEEE ITS Magazine.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"275829",title:"Dr.",name:"Esther",middleName:null,surname:"Villar-Rodriguez",slug:"esther-villar-rodriguez",fullName:"Esther Villar-Rodriguez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/275829/images/system/275829.jpg",biography:"Dr. Esther Villar obtained a Ph.D. in Information and Communication Technologies from the University of Alcalá, Spain, in 2015. She obtained a degree in Computer Science from the University of Deusto, Spain, in 2010, and an MSc in Computer Languages and Systems from the National University of Distance Education, Spain, in 2012. Her areas of interest and knowledge include natural language processing (NLP), detection of impersonation in social networks, semantic web, and machine learning. Dr. Esther Villar made several contributions at conferences and publishing in various journals in those fields. Currently, she is working within the OPTIMA (Optimization Modeling & Analytics) business of TECNALIA’s ICT Division as a data scientist in projects related to the prediction and optimization of management and industrial processes (resource planning, energy efficiency, etc).",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"49813",title:"Dr.",name:"Javier",middleName:null,surname:"Del Ser",slug:"javier-del-ser",fullName:"Javier Del Ser",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49813/images/system/49813.png",biography:"Prof. Dr. Javier Del Ser received his first PhD in Telecommunication Engineering (Cum Laude) from the University of Navarra, Spain, in 2006, and a second PhD in Computational Intelligence (Summa Cum Laude) from the University of Alcala, Spain, in 2013. He is currently a principal researcher in data analytics and optimisation at TECNALIA (Spain), a visiting fellow at the Basque Center for Applied Mathematics (BCAM) and a part-time lecturer at the University of the Basque Country (UPV/EHU). His research interests gravitate on the use of descriptive, prescriptive and predictive algorithms for data mining and optimization in a diverse range of application fields such as Energy, Transport, Telecommunications, Health and Industry, among others. In these fields he has published more than 240 articles, co-supervised 8 Ph.D. theses, edited 6 books, coauthored 7 patents and participated/led more than 40 research projects. He is a Senior Member of the IEEE, and a recipient of the Biscay Talent prize for his academic career.",institutionString:"Tecnalia Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"278948",title:"Dr.",name:"Carlos Pedro",middleName:null,surname:"Gonçalves",slug:"carlos-pedro-goncalves",fullName:"Carlos Pedro Gonçalves",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRcmyQAC/Profile_Picture_1564224512145",biography:'Carlos Pedro Gonçalves (PhD) is an Associate Professor at Lusophone University of Humanities and Technologies and a researcher on Complexity Sciences, Quantum Technologies, Artificial Intelligence, Strategic Studies, Studies in Intelligence and Security, FinTech and Financial Risk Modeling. He is also a progammer with programming experience in:\n\nA) Quantum Computing using Qiskit Python module and IBM Quantum Experience Platform, with software developed on the simulation of Quantum Artificial Neural Networks and Quantum Cybersecurity;\n\nB) Artificial Intelligence and Machine learning programming in Python;\n\nC) Artificial Intelligence, Multiagent Systems Modeling and System Dynamics Modeling in Netlogo, with models developed in the areas of Chaos Theory, Econophysics, Artificial Intelligence, Classical and Quantum Complex Systems Science, with the Econophysics models having been cited worldwide and incorporated in PhD programs by different Universities.\n\nReceived an Arctic Code Vault Contributor status by GitHub, due to having developed open source software preserved in the \\"Arctic Code Vault\\" for future generations (https://archiveprogram.github.com/arctic-vault/), with the Strategy Analyzer A.I. module for decision making support (based on his PhD thesis, used in his Classes on Decision Making and in Strategic Intelligence Consulting Activities) and QNeural Python Quantum Neural Network simulator also preserved in the \\"Arctic Code Vault\\", for access to these software modules see: https://github.com/cpgoncalves. He is also a peer reviewer with outsanding review status from Elsevier journals, including Physica A, Neurocomputing and Engineering Applications of Artificial Intelligence. Science CV available at: https://www.cienciavitae.pt//pt/8E1C-A8B3-78C5 and ORCID: https://orcid.org/0000-0002-0298-3974',institutionString:"University of Lisbon",institution:{name:"Universidade Lusófona",country:{name:"Portugal"}}},{id:"241400",title:"Prof.",name:"Mohammed",middleName:null,surname:"Bsiss",slug:"mohammed-bsiss",fullName:"Mohammed Bsiss",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/241400/images/8062_n.jpg",biography:null,institutionString:null,institution:null},{id:"276128",title:"Dr.",name:"Hira",middleName:null,surname:"Fatima",slug:"hira-fatima",fullName:"Hira Fatima",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/276128/images/14420_n.jpg",biography:"Dr. Hira Fatima\nAssistant Professor\nDepartment of Mathematics\nInstitute of Applied Science\nMangalayatan University, Aligarh\nMobile: no : 8532041179\nhirafatima2014@gmal.com\n\nDr. Hira Fatima has received his Ph.D. degree in pure Mathematics from Aligarh Muslim University, Aligarh India. Currently working as an Assistant Professor in the Department of Mathematics, Institute of Applied Science, Mangalayatan University, Aligarh. She taught so many courses of Mathematics of UG and PG level. Her research Area of Expertise is Functional Analysis & Sequence Spaces. She has been working on Ideal Convergence of double sequence. She has published 17 research papers in National and International Journals including Cogent Mathematics, Filomat, Journal of Intelligent and Fuzzy Systems, Advances in Difference Equations, Journal of Mathematical Analysis, Journal of Mathematical & Computer Science etc. She has also reviewed few research papers for the and international journals. She is a member of Indian Mathematical Society.",institutionString:null,institution:null},{id:"414880",title:"Dr.",name:"Maryam",middleName:null,surname:"Vatankhah",slug:"maryam-vatankhah",fullName:"Maryam Vatankhah",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Borough of Manhattan Community College",country:{name:"United States of America"}}},{id:"414879",title:"Prof.",name:"Mohammad-Reza",middleName:null,surname:"Akbarzadeh-Totonchi",slug:"mohammad-reza-akbarzadeh-totonchi",fullName:"Mohammad-Reza Akbarzadeh-Totonchi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Ferdowsi University of Mashhad",country:{name:"Iran"}}},{id:"414878",title:"Prof.",name:"Reza",middleName:null,surname:"Fazel-Rezai",slug:"reza-fazel-rezai",fullName:"Reza Fazel-Rezai",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"American Public University System",country:{name:"United States of America"}}},{id:"426586",title:"Dr.",name:"Oladunni A.",middleName:null,surname:"Daramola",slug:"oladunni-a.-daramola",fullName:"Oladunni A. Daramola",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Federal University of Technology",country:{name:"Nigeria"}}},{id:"357014",title:"Prof.",name:"Leon",middleName:null,surname:"Bobrowski",slug:"leon-bobrowski",fullName:"Leon Bobrowski",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Bialystok University of Technology",country:{name:"Poland"}}},{id:"302698",title:"Dr.",name:"Yao",middleName:null,surname:"Shan",slug:"yao-shan",fullName:"Yao Shan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Dalian University of Technology",country:{name:"China"}}},{id:"354126",title:"Dr.",name:"Setiawan",middleName:null,surname:"Hadi",slug:"setiawan-hadi",fullName:"Setiawan Hadi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Padjadjaran University",country:{name:"Indonesia"}}},{id:"125911",title:"Prof.",name:"Jia-Ching",middleName:null,surname:"Wang",slug:"jia-ching-wang",fullName:"Jia-Ching Wang",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"National Central University",country:{name:"Taiwan"}}},{id:"332603",title:"Prof.",name:"Kumar S.",middleName:null,surname:"Ray",slug:"kumar-s.-ray",fullName:"Kumar S. Ray",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Indian Statistical Institute",country:{name:"India"}}},{id:"415409",title:"Prof.",name:"Maghsoud",middleName:null,surname:"Amiri",slug:"maghsoud-amiri",fullName:"Maghsoud Amiri",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Allameh Tabataba'i University",country:{name:"Iran"}}},{id:"357085",title:"Mr.",name:"P. Mohan",middleName:null,surname:"Anand",slug:"p.-mohan-anand",fullName:"P. Mohan Anand",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Indian Institute of Technology Kanpur",country:{name:"India"}}},{id:"356696",title:"Ph.D. Student",name:"P.V.",middleName:null,surname:"Sai Charan",slug:"p.v.-sai-charan",fullName:"P.V. 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Thus all studies on metabolism will be considered for publication.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11413,editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",slug:"yannis-karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",biography:"Yannis Karamanos, born in Greece in 1953, completed his pre-graduate studies at the Université Pierre et Marie Curie, Paris, then his Masters and Doctoral degree at the Université de Lille (1983). He was associate professor at the University of Limoges (1987) before becoming full professor of biochemistry at the Université d’Artois (1996). He worked on the structure-function relationships of glycoconjugates and his main project was the investigations on the biological roles of the de-N-glycosylation enzymes (Endo-N-acetyl-β-D-glucosaminidase and peptide-N4-(N-acetyl-β-glucosaminyl) asparagine amidase). From 2002 he contributes to the understanding of the Blood-brain barrier functioning using proteomics approaches. He has published more than 70 papers. 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