\\n\\n
IntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\\n\\nIntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
\\n\\nLaunching 2021
\\n\\nArtificial Intelligence, ISSN 2633-1403
\\n\\nVeterinary Medicine and Science, ISSN 2632-0517
\\n\\nBiochemistry, ISSN 2632-0983
\\n\\nBiomedical Engineering, ISSN 2631-5343
\\n\\nInfectious Diseases, ISSN 2631-6188
\\n\\nPhysiology (Coming Soon)
\\n\\nDentistry (Coming Soon)
\\n\\nWe invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
\\n\\nNote: Edited in October 2021
\\n"}]',published:!0,mainMedia:{caption:"",originalUrl:"/media/original/132"}},components:[{type:"htmlEditorComponent",content:'With the desire to make book publishing more relevant for the digital age and offer innovative Open Access publishing options, we are thrilled to announce the launch of our new publishing format: IntechOpen Book Series.
\n\nDesigned to cover fast-moving research fields in rapidly expanding areas, our Book Series feature a Topic structure allowing us to present the most relevant sub-disciplines. Book Series are headed by Series Editors, and a team of Topic Editors supported by international Editorial Board members. Topics are always open for submissions, with an Annual Volume published each calendar year.
\n\nAfter a robust peer-review process, accepted works are published quickly, thanks to Online First, ensuring research is made available to the scientific community without delay.
\n\nOur innovative Book Series format brings you:
\n\nIntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\n\nIntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
\n\nLaunching 2021
\n\nArtificial Intelligence, ISSN 2633-1403
\n\nVeterinary Medicine and Science, ISSN 2632-0517
\n\nBiochemistry, ISSN 2632-0983
\n\nBiomedical Engineering, ISSN 2631-5343
\n\nInfectious Diseases, ISSN 2631-6188
\n\nPhysiology (Coming Soon)
\n\nDentistry (Coming Soon)
\n\nWe invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
\n\nNote: Edited in October 2021
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Particularly, they are the most relevant sources of plant proteins with nutraceutical and health benefit properties. This book was conceived to provide key research knowledge on health-promoting aspects of seed components, and their nutritional and nutraceutical values, for increasing awareness among the population of the research focus across the growing field of legume research, and the area of sustainable crop production.",isbn:"978-1-78985-398-8",printIsbn:"978-1-78985-397-1",pdfIsbn:"978-1-83962-023-2",doi:"10.5772/intechopen.75158",price:100,priceEur:109,priceUsd:129,slug:"legume-seed-nutraceutical-research",numberOfPages:96,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"a01ad0ca780f39f3aefd09f00cd0b7a3",bookSignature:"Jose C. Jimenez-Lopez and Alfonso Clemente",publishedDate:"February 13th 2019",coverURL:"https://cdn.intechopen.com/books/images_new/7337.jpg",numberOfDownloads:7629,numberOfWosCitations:3,numberOfCrossrefCitations:23,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:50,numberOfDimensionsCitationsByBook:0,hasAltmetrics:1,numberOfTotalCitations:76,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"February 13th 2018",dateEndSecondStepPublish:"March 6th 2018",dateEndThirdStepPublish:"May 5th 2018",dateEndFourthStepPublish:"July 24th 2018",dateEndFifthStepPublish:"September 22nd 2018",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"33993",title:"Dr.",name:"Jose Carlos",middleName:null,surname:"Jimenez-Lopez",slug:"jose-carlos-jimenez-lopez",fullName:"Jose Carlos Jimenez-Lopez",profilePictureURL:"https://mts.intechopen.com/storage/users/33993/images/system/33993.jpg",biography:"Dr. Jose C. Jimenez-Lopez, BS. Biochemistry (1998), BS. Biological Sciences (2001), MS. Agricultural Sciences (2004), University of Granada, Spain; and Ph.D. Plant Cell Biology (2008) at CSIC. He was a Postdoctoral Research Associate at Purdue University, USA (2008-2011), and Marie Curie Research Fellow (EU - FP7) (2012-2015) at the University of Western Australia and CSIC. Currently, he is a Senior Research Fellow (Ramon y Cajal research program, 2016 - present), working in the functionality, health benefits, and molecular allergy aspects of seed proteins from crop species of agro-industrial interest (mainly legumes). He is the author of more than 65 journal articles, 29 book chapters, 2 patents, and more than 130 international congresses. He is an active member of different Scientific Societies and editor of multiple books.",institutionString:"Spanish National Research Council",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"8",totalChapterViews:"0",totalEditedBooks:"7",institution:{name:"Spanish National Research Council",institutionURL:null,country:{name:"Spain"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:{id:"149660",title:"Dr.",name:"Alfonso",middleName:null,surname:"Clemente",slug:"alfonso-clemente",fullName:"Alfonso Clemente",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRDEMQA4/Profile_Picture_1615291343716",biography:"Dr. Alfonso Clemente is a staff scientist at the Spanish National Research Council, working at the Estación Experimental del Zaidín (Granada, Spain). He has been working in legume seeds for the last 20 years, being involved in several national and international related projects. Alfonso Clemente joined different labs (Institute of Food Research, 1999–2000; John Innes Centre, 2000–2002; Sainsbury Laboratory, 2003–2004) in the UK to broaden his laboratory skills and scientific knowledge. Currently, he is the President of the Spanish Legume Association (Asociación Española de Leguminosas, www.leguminosas.es) having strong interaction with a relevant network of scientists and agricultural associations and agri-food companies in the field. He is author of more than 120 scientific manuscripts and an editorial board member of the World Journal of Gastroenterology and Frontiers in Bioscience, among others.",institutionString:"Spanish National Research Council",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"2",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"Estación Experimental del Zaidín",institutionURL:null,country:{name:"Spain"}}},coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"335",title:"Seed Technology",slug:"food-science-seed-technology"}],chapters:[{id:"62638",title:"Nutraceutical Properties of Legume Seeds and Their Impact on Human Health",doi:"10.5772/intechopen.78799",slug:"nutraceutical-properties-of-legume-seeds-and-their-impact-on-human-health",totalDownloads:1657,totalCrossrefCites:11,totalDimensionsCites:18,hasAltmetrics:1,abstract:"Legume seeds known to produce richer quality of proteins than cereals provide nutritious food for people around the world. Legume seeds contain around 20–40% protein. Apart from protein, it is also composed of carbohydrates, fiber, amino acids, micronutrients including several vitamins and minerals. Legume seeds can be considered a potent nutraceutical as it provides beneficial effects on human health as well as it helps in the prevention or treatment of certain diseases such as cardiovascular diseases, diabetes, digestive tract diseases, overweight, obesity, cancer, etc. Legume seeds also contain anti-nutritional compounds which may be toxic when consumed raw, but when processed and treated may play a positive role on human health. There are many more underutilized food legume seeds that may be a potential source of nutraceutical food. The main aim of this chapter is to describe the nutraceutical properties of legume seeds and their impact on human health.",signatures:"Arindam Barman, Chinky M. Marak, Rituparna Mitra Barman and\nCheana S. Sangma",downloadPdfUrl:"/chapter/pdf-download/62638",previewPdfUrl:"/chapter/pdf-preview/62638",authors:[null],corrections:null},{id:"62359",title:"Two Sides of the Same Coin: The Impact of Grain Legumes on Human Health: Common Bean (Phaseolus vulgaris L.) as a Case Study",doi:"10.5772/intechopen.78737",slug:"two-sides-of-the-same-coin-the-impact-of-grain-legumes-on-human-health-common-bean-phaseolus-vulgari",totalDownloads:1373,totalCrossrefCites:3,totalDimensionsCites:6,hasAltmetrics:1,abstract:"Data from Food and Agriculture Organization indicate the worrying scenario of severe food insecurity in the world and the contrasting high prevalence of obesity (13% of the world adult population) in both developing and developed countries. Sustainable agriculture systems with increased inclusion of grain legume species and the boosting of public awareness about legume importance on diet should be a priority issue to eradicate malnutrition and promote public health. However, grain legume production and consumption are in constant state of decline, especially in the European Union. Assigned as the “poor man’s meat”, “promoters of flatulence”, or incorrectly classified as “starchy foods”, grain legumes have a negative image in modern societies. In fact, legumes represent an important source of protein, fiber, vitamins (e.g. folate) and minerals (e.g. magnesium). Moreover, legumes are rich in bioactive compounds (e.g. phenolic compounds, protease and α-amylase inhibitors) acting as a “double-edged sword” in human health. They may impair nutrients availability exerting at the same time beneficial biological activities in lipid profile, inflammation, glycaemia and weight. The present chapter is focused on the advantages of a legume-rich diet for health promotion at a global scale, reviewing legume nutritional and bioactive compounds, with particular emphasis on common bean.",signatures:"Elsa Mecha, Maria Eduardo Figueira, Maria Carlota Vaz Patto and\nMaria do Rosário Bronze",downloadPdfUrl:"/chapter/pdf-download/62359",previewPdfUrl:"/chapter/pdf-preview/62359",authors:[null],corrections:null},{id:"62227",title:"Cowpea: A Strategic Legume Species for Food Security and Health",doi:"10.5772/intechopen.79006",slug:"cowpea-a-strategic-legume-species-for-food-security-and-health",totalDownloads:3034,totalCrossrefCites:5,totalDimensionsCites:18,hasAltmetrics:0,abstract:"In this chapter, several characteristics of cowpea (Vigna unguiculata), including nutritional and nutraceutical properties, and economic and social aspects of production were analysed with the objective to demonstrate that cowpea is a culture suitable for inclusion in food security programs. Cowpea is rich in diverse nutrients, highlighting high levels of protein. Cowpea also is rich in nutraceuticals compounds such as dietary fibre, antioxidants and polyunsaturated fatty acids and polyphenols. Widely cultivated and consumed cowpea is the very important legume for the nutrition and health of millions of people in many countries. In addition to being nutritious and safe, cowpea has high relative productivity, production stability and high tolerance to environmental stresses such as drought. Cowpea also has economic viability, low environmental impact and contributes to the conservation of natural resources and the sustainability of production systems. Cowpea is a safe food, always available in most regions, low priced compared to other sources of protein. Based on the analyses performed, it is possible to infer that cowpea is a strategic culture for the promotion of food security and health of populations on all continents.",signatures:"Alexandre Carneiro da Silva, Dyego da Costa Santos, Davair Lopes\nTeixeira Junior, Pedro Bento da Silva, Rosana Cavalcante dos Santos\nand Amauri Siviero",downloadPdfUrl:"/chapter/pdf-download/62227",previewPdfUrl:"/chapter/pdf-preview/62227",authors:[null],corrections:null},{id:"62401",title:"Prosopis cineraria as an Unconventional Legumes, Nutrition and Health Benefits",doi:"10.5772/intechopen.79291",slug:"prosopis-cineraria-as-an-unconventional-legumes-nutrition-and-health-benefits",totalDownloads:1566,totalCrossrefCites:4,totalDimensionsCites:8,hasAltmetrics:0,abstract:"Prosopis cineraria (L.) Druce is considered as one of the highly valued plants in the native system of medicine for many arid and dry areas in the world. Ancient literature for Arabian Gulf and Indian desert illustrated the important of the plant in treated various ailments like asthma, dysentery, leucoderma, leprosy, dyspepsia, earache, etc. The present chapter review the using of P. cineraria as unconventional legumes that not well known as a rich and sustainable source of protein for many people in the world. It emphasis on its broad food and nonfood applications, nutritional values and health benefits. As well as looking at the phytochemical constituent’s content that has been identified in the various parts of the plant as alkaloid, steroids, alcohol and alkane. The present paper describes the morphological trait of P. cineraria and identifies the environmental conditions required for its natural distribution. Historically, this plant has drag attention for its various uses therefore, it has been considered as the National Tree of the United Arab Emirates in the Arabian Gulf.",signatures:"Hanan Sobhy Amin Afifi and Ihsan Abu Al-rub",downloadPdfUrl:"/chapter/pdf-download/62401",previewPdfUrl:"/chapter/pdf-preview/62401",authors:[null],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"6096",title:"Seed Biology",subtitle:null,isOpenForSubmission:!1,hash:"0929ebc410ef5c25efdf938e3d34b6b2",slug:"advances-in-seed-biology",bookSignature:"Jose C. 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The real cause of developing their unpredictable debilitating symptoms has remained a mystery among doctors and scientists for years. However, the past decade was a turning point in uncovering the pathophysiology of these entities and discovering new treatments for cases that are resistant to conventional therapy. This book will discuss the most recent breakthroughs in the molecular mechanism of angioedema and urticaria, while providing updates on the newest possible etiologies and causes of these conditions, including hereditary angioedema with or without C1 inhibitor deficiency, FXII-related malfunctions, and chronic spontaneous urticaria (CSU). Moreover, the book intends to underline the latest treatments that have revolutionized the management of these diseases, with a focus on the different rising therapies in resistant cases, especially the newest monoclonal antibodies. This will update dermatologists and physicians on the myriad options we can use in cases that were once considered impossible to treat.
",isbn:"978-1-83969-228-4",printIsbn:"978-1-83969-227-7",pdfIsbn:"978-1-83969-232-1",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,isNomenclature:!1,hash:"0315e9d2989fad5f055e4ad856f77b76",bookSignature:"Dr. Charbel Skayem and Dr. Tu Anh Duong",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11816.jpg",keywords:"Hereditary, C1 Inhibitor, C1q, IgE-Mediated, Non-IgE-Mediated, Histamine, Degranulation, Mast Cells, Neuropeptide, Hypersensitivity, Auto-Immune, Anti-histamine",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"April 20th 2022",dateEndSecondStepPublish:"June 29th 2022",dateEndThirdStepPublish:"August 28th 2022",dateEndFourthStepPublish:"November 16th 2022",dateEndFifthStepPublish:"January 15th 2023",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"a month",secondStepPassed:!0,areRegistrationsClosed:!1,currentStepOfPublishingProcess:3,editedByType:null,kuFlag:!1,biosketch:"Dr. Charbel Skayem is a dermatologist and venereologist in Assistance Publique-Hôpitaux de Paris(AP-HP), the largest university hospital system in Europe, and Gustave Roussy, the first cancer research hospital in Europe and among the top 5 best-specialized hospitals in the world. Dr. Skayem graduated from the Sorbonne University, University of Paris, and Paris-Saclay University, and is a member of several dermatological societies and academies, and the author of numerous articles in top leading journals.",coeditorOneBiosketch:"Dermatologist in Assistance Publique des Hôpitaux de Paris (AP-HP), the largest university hospital system in Europe, Paris-Saclay University, and a numeric design engineer in medicine. President of teledermatology in the French Society of dermatology and coordinator of TELDERM AP-HP.",coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"461547",title:"Dr.",name:"Charbel",middleName:null,surname:"Skayem",slug:"charbel-skayem",fullName:"Charbel Skayem",profilePictureURL:"https://mts.intechopen.com/storage/users/461547/images/system/461547.jpg",biography:"Dr Charbel Skayem is a dermatologist, venereologist, and dermatologic surgeon practicing in Assistance Publique des Hôpitaux de Paris (AP-HP), the largest university hospital system in Europe and one of the largest in the world, and in Gustave Roussy, the first cancer-research hospital in Europe and among the top 5 best specialized university hospitals in the world. Lebanese in origin, he moved to Paris to pursue his residency in dermatology and venereology, followed by several fellowships, graduating from the Sorbonne University, the University of Paris, and Paris-Saclay University. His initial experiences in different worldwide-renowned pioneer referral departments have given him a wide expertise in multiple branches of his specialty: oncodermatology, advanced dermatologic surgery, inflammatory and infectious dermatology, teledermatology, sexually transmitted diseases, and cosmetic and laser dermatology. Dr Skayem is a member of different dermatological societies and academies. He was a laureate of several scholarships and awards. He was a distinguished speaker in many global congresses. Despite his youth, he served as a reviewer and editor, has written several chapters in books, and numerous articles in leading peer-reviewed medical journals.",institutionString:"Assistance Publique -Hopitaux De Paris",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"Assistance Publique -Hopitaux De Paris",institutionURL:null,country:{name:"France"}}}],coeditorOne:{id:"462437",title:"Dr.",name:"Tu Anh",middleName:null,surname:"Duong",slug:"tu-anh-duong",fullName:"Tu Anh Duong",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003QRGVyQAP/Profile_Picture_2022-04-21T07:34:55.png",biography:"Dr Tu Anh Duong is a dermatologist in Assistance Publique des Hôpitaux de Paris (AP-HP), the largest hospital system in Europe, Paris-Saclay University, and a numeric design engineer in medicine. Affiliated to leading referral departments in dermatology (in toxic epidermal necrolysis, bullous dermatological diseases, severe cutaneous adverse reactions, dermatological emergencies, and neurofibromatosis), Dr. Duong has wide expertise in severe skin disorders. She is an innovator in the field of teledermatology and is the president of teledermatology in the French Society of dermatology, the coordinator of TELDERM AP-HP, and Chair Avenir Santé Numérique. Her innovations and interest fields lie in dermatological emergencies and engineering dermatological numeric transformations and conversions. 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Tectonic sketch map of the Caribbean area
The crustal thickness of the Caribbean Plate varies from, 6-8 km, west of the Beata Ridge, to 20 km between the Central Venezuelan and the western part of the Beata Ridge until, 3-5 km in the southeast of the Venezuela Basin (Diebold & Driscoll, 1999). The crust varies also in thickness from Yucatán Basin (8-9 km, Hall 1995) to Colombian and Grenada Basins. The thickness of the marginal belts ranges from 10 - 22 km to 18 km (Case et al., 1990).
The Caribbean lithosphere has been deformed and tectonically emplaced over the Pacific and Atlantic oceanic crusts producing the western and eastern arc systems of the Central American Isthmus and Lesser Antilles. It has also been squeezed against the North and South American continental crusts, thereby originating suture zones in the Cordilleras of Guatemala, Greater Antilles and Venezuela. More internal Caribbean marginal areas in Venezuela, Colombia, Panama and Hispaniola are shortened forming “accretionary prisms” with a centripetal vergence (Stephan et al., 1986).
Bivergent “flower structures” exist along the northern and southern Caribbean margins where diachronous oblique movements have occurred from the Cretaceous until present time. The active northern (Guatemala and Greater Antilles) and southern (northern Venezuela) plate margins are mainly made by deformed terranes in shear zones bounded by east-west trending sinistral and dextral strike-slip faults respectively. The western (Central America Isthmus) and eastern (Lesser Antilles) are represented by convergent systems and related magmatic arcs. The Caribbean marginal belts are the product of complex interaction between several first-order geotectonic elements, characterized by different tectono-magmatic features and originated in different paleo-domains, that now lie fragmented and dispersed along the margins. The paleo-domains include continental margins, rifted continental margins, thin oceanic crust, oceanic plateau, intra-oceanic and sub-continental subduction zones and foredeep basins.
The interaction between portions of these domains produced the present-day settlement of the plate, recording same important compressional episodes, beginning in the Cretaceous, followed by tensional and/or strike-slip tectonics; the reconstruction of the evolution of which encounters several problems mainly related to unresolved facts (Giunta & Oliveri, 2009).
The Caribbean Plate margins include several terranes, in particular Jurassic-Cretaceous ophiolitic complexes, exposed along suture zones or as accreted terranes on the northern, southern and western sectors of the plate, and subordinately in the eastern one (Fig.2).
These terranes, bounded by regional strike-slipe faults, are made up by several tectonic units, which have been reconstructed in terms of tectono-stratigraphic evolution, and correlated at the plate scale.
The peri-Caribbean tectonic units and their numerous formations can be grouped into at least six litho-stratigraphic sections with similar lithologic characteristics but very different tectonic origins, mainly based on the petrologic data characterizing the geochemical affinities of the magmatic lithotypes (Fig. 3). Each unit corresponds to the litho-stratigraphic development of related geodynamic elements, characterizing different tectono-magmatic environments (Cobiella-Reguera, 2005; Giunta et al., 2002b; Lewis et al., 2002, 2006a, 2006b) as:
1. Mesozoic continental margins (Bahamas Platform, northern South America, the Maya and Chortis blocks of Central America, Guaniguanico in Cuba, Cordillera de la Costa in Venezuela), including a pre-Mesozoic basement;
2. rifted continental margins (Escambray in Cuba, Caucagua-El Tinaco and Tinaquillo in Venezuela) related to Jurassic-early Cretaceous tensional episodes which continued to affect the continental margins, characterized by Within Plate Tholeiitic (WPT) magmatism;
Tectonic sketch map of the Caribbean area
3. Jurassic-Early Cretaceous oceanic crust, with Mid Ocean Ridge (MORB) affinity (North and South Motagua in Guatemala, Northern Ophiolite in Cuba, Northern Cordillera in Hispaniola, Sierra Bermeja in Puerto Rico, Loma de Hierro and Franja Costera in Venezuela);
4. “thin” oceanic crust in places evolved into an oceanic plateau structure with related Ocean Island Basalts (OIB) during the Cretaceous (Santa Elena, Matapalo and Esperanza in Costa Rica, Loma Caribe, Central Cordillera and Massif de la Hotte in Hispaniola, Dutch-Venezuelan islands) ;
5a. mid-Cretaceous intra-oceanic Supra Subduction Zones (SSZ) and related volcanic arc magmatism, with Island Arc Tholeiitic (IAT) and/or calc-alkaline (CA) affinities (Sierra Santa Cruz, Baja Verapaz and Juan de Paz in Guatemala, Mabujina, Cretaceous Arc, Mayarì-Baracoa and Purial in Cuba, Maimon-Los Ranchos in Hispaniola, Villa de Cura and Dos Hermanas in Venezuela), in places affected by HP/LT metamorphism;
5b. mid-Cretaceous sub-continental subductions, with formation of HP-LT metamorphosed ophiolitic melanges, including mafic blocks with MOR affinity (Franja Costera in Venezuela);
6. Late Cretaceous to Eocene Tonalitic Arc magmatism with calc-alkaline (CA) affinity (intruding: South Motagua in Guatemala, Mabujna and Cretaceous Arc in Cuba, Cordillera Central in Hispaniola, Dutch-Venezuelan islands and part of Caucagua-El Tinaco in Venezuela);
7. Late Cretaceous mélanges (Northern Ophiolite in Cuba, Northern Cordillera in Hispaniola), followed by Paleogene olistostromes, involving blocks of different origin (MOR, SSZ) in the deformation fronts, colliding against the NOAM and SOAM continental plates, through the progressive activation of foredeep basins (Sepur in Guatemala, Piemontine in Venezuela).
Regional correlations between the main sedimentary, magmatic, metamorphic, and deformational events recorded in the peri-Caribbean terranes. Abbreviations: SJO, Costa Rica; GUA, Guatemala; HAB, Cuba; SDQ, Hispaniola; HA, Haiti; PRC, Puerto Rico; VNZ, Venezuela; WPT, within-plate tholeiite; MOR, mid-ocean ridge; OIB, ocean islands basalt; IAT, island arc tholeiite; CA, island arc calc-alkaline; GR, tonatitic arc magmatism (gabbroid to granitoid). 1–27: most representative formations. Continental margins: 1, Sebastopol complex (VNZ): continental metamorphic basement (mainly gneiss), with granitic intrusions; 2, Las Brisas (VNZ): phyllite, metasiltites and meta-arenites, with intercalations of metacalcarenites; Todos Santos (GUA): reddish arenites and siltites, with intercalations of limestones and poligenic conglomerates; 3, Antimano (VNZ): metacalcarenites and marbles, with intercalations of amphibolites and metabasites; 4, Las Mercedes (VNZ): graphitic phyllites, metacalcarenites, with scarce intercalations of metabasites; Chuspita (VNZ): meta-arenites, metasiltites and metaconglomerates, with intercalations of marbles; Coban (GUA): evaporites, dolomites and limestones; 5, Campur (GUA): limestones, with intercalations of siltites. Rifted continental margins: 6, Tinaquillo, Cerro Matasiete (VNZ): serpentinized lherzolites; 7, El Tinaco complex (VNZ): continental basement made by gneiss with few amphibolites, phillites, metaconglomerates and meta-arenites; 8, Juan Griego (VNZ): continental crystalline (quartz, feldspar, rich schist and ortho or paragneisses) basement; 9, Rinconada, Tinaquillo p.p. (VNZ): metagabbro cumulates intruded and overlying the 8; 10, Sabana Larga (VNZ): basalts (mainly pillow lavas), dolerites and gabbro breccias; 11, Tucutunemo, Los Naranjos, Los Robles (VNZ): metalimestones and metasiltites with basaltic pillow lavas. Proto-Caribbean ocean: 12, Gaspar Hernandez (SDQ), Monte del Estado (PRC): serpentinized peridotites; 13, Cuaba (SDQ), Rio Mesia (VNZ): layered metagabbros; 14, El Tambor group (GUA), Punta Balandra (SDQ), Sierra Bermeja (PRC), Tiara (VNZ): metasiltites, meta-arenites, metacalcarenites, with intercalations of basaltic (flows or pillow lavas) and radiolarian cherts; 15, Cerro de la Virgen (GUA): metacalcarenites and metacalcasiltites with breccia and siltitic intercalations. Proto-Caribbean oceanic plateau: 16, Loma Caribe (SDQ): serpentinized peridotites; 17, Potrero (SJO): gabbro cumulates, Fe-gabbros, Fe-diorites and subordinate plagiogranites; 18, Punta Conchal (SJO): radiolarites intercalated in pillow and massive basalts; 19, Duarte complex (SDQ), Lava (CUR): pillow and massive basalts with intercalations of radiolarites and volcanoclastites; 20, Siete Cabezas (SDQ), Knip group (CUR): volcanoclastites, radiolarites; pillow and massive basalts; 19, 20, Dumissieu (HA): pillow and massive basalts, volcanoclastites, with intercalations of radiolarites. First eo-Caribbean SSZ and volcanic arc: 21, serpentinized peridotites; 22, layered gabbros with scattered intrusions of granites; Chacao complex 21 þ 22 (VNZ), Mayarı` Baracoa (HAB); 23, Mabujina, Purial (HAB), El Carmen, El Chino, El Cano, S. Isabel (VNZ): metabasalts (mainly pillow lavas), metadolerites and meta-andesites; 24, Hatillo (SDQ): reefal limestones; 25, Tzumuy, Cerro Tipon (GUA): calcarenites and carbonatic breccias.
The present-day tectonic characters of the plate margins are shown in the cartoon cross-section of the Fig. 4, where the Caribbean Plateau (Colombia and Venezuela Basins) obduces the Atlantic and Pacific crusts, along the Barbados accretionary prism and Central America trench respectively, and is collided against the North and South America continental crusts with the intermediate of some ophiolitic terranes, along left-lateral and right-lateral fault aligneament respectively.
Generalized cross-section of the peri-Caribbean collisional belts (Late Cretaceous-Paleogene)
The correlations of above mentioned main units involved in the Caribbean terranes showing different characteristics, point-up some important times related to origin, growth and evolution of the Plate, which represent the fundamental constraints for elaborate any evolutionary model.
The Pangea breakup and related split of South and North American, Maya and Chortis plates or blocks, favoured rifting and tholeiitic magmatism (WPT), along extensional faults cutting the continental crust, corresponding to the inferred continental margins units.
Mid-Ocean Ridge (MOR) oceanic crust formed at multiple spreading centres during the Jurassic and Early Cretaceous, forming the “proto-Caribbean” ocean, corresponding to ocean floor units.
During the Cretaceous, parts of the oceanic crustal domain thickened, forming an oceanic plateau structure, of petrologic MOR to Ocean Island Basalt (OIB) affinity, represented by the oceanic plateau units.
Several lines of geological evidence, as relict HP-LT distribution, record the occurrence of different subduction complexes (eo-Caribbean stages), both intra-oceanic (IAT and CA arc magmatism associated to SSZ) and/or sub-continental (mélanges), maybe coupled with trapped or back-arc oceanic crust. In both mid- (120-95 My) and Late Cretaceous (85-70 My) peaks of IAT and CA arc magmatism associated with the SSZ occurred in the eo-Caribbean accretionary stage, which has been separated in 1^ and 2^ eo-Caribbean phases of subduction.
The beginning of the accretionary stage seems to have been diachronous, between 115 and 95 My (Escuder-Viruete & Pérez-Estaún 2006b; Giunta et al., 2003b; Smith et al., 1999), according to HP/LT assemblages related to ocean-ocean subduction and to ocean-continent subduction that locally reached eclogite facies, which demonstrate the early convergence in the Caribbean.
During the Cretaceous have been recognized two main SSZ related magmatism: the resulting double-arc magmatism is associated, the first (mid-Cretaceous), with subduction related to metamorphism; the second (Late Cretaceous) with subduction exhumation related to metamorphism. Both events occurred in the eo-Caribbean accretionary stage, which has been separated in 1^ and 2^ eo-Caribbean phases of subduction.
Widespread occurrences of blueschist and eclogite assemblages (García-Casco et al., 2006b; Rojas-Agramonte et al., 2006a) in both oceanic and continental terranes of the Caribbean plate margins requires a geodynamic model where portions of both oceanic and continental lithospheres were simultaneously subducted.
The older volcanic arc presents an atypical evolution: in fact the mid-Cretaceous island-arc system was frequently deeply subducted and affected by blueschist facies metamorphism. In general, supra-subduction zone units obduct onto continental margins and only locally become involved in the deep part of the subduction complex; in these cases an unusual geodynamic evolution must be supposed.
Contrasts in the P-T paths of various HP-LT metamorphic units (Garcia-Casco et al., 2006a; Sisson et al., 1997) probably indicate that converging zones were subdivided into different sectors, characterized by different tectonic settings, during the mid-Cretaceous. This may be reflecting a more realistic issue on the physical parameters of the subduction zones, that should show a variable thermobaric structure. According to Giunta et al. (2003a) and references therein), some eclogites and blueschists followed an “Alpine-type” retrograde trajectory, suggesting that shut-off of the subduction occurred before the beginning of exhumation. In contrast, blueschists locally show a “Franciscan-type” path, which commonly characterizes decompression in intra-oceanic settings during still active subduction processes.
In the Late Cretaceous, the distribution of the second calcalkaline magmatic arc, mainly tonalitic, seems to be diachronously connected to the Aves-Lesser Antilles arc system since 85 My. Differences in the northern and southern Caribbean margins are noted. In the north the tonalitic magmatic arc generally rests on both older arc systems and oceanic plateau. In the south it is tectonically decoupled from the older arc and is intruded into both undeformed and deformed oceanic plateau and into some rifted continental margin units.
On the base of the available data the evolution of the Caribbean Plate followed some steps (Fig.5), as:
proto- Carribean event: oceanic spreading and plume events;
1° eo-Caribbean phase of subduction: volcano-plutonic sequence with IAT or CA affinities, in places affected by HP-LT metamorphism;
2° eo-Caribbean phase of subduction: un-metamorphosed tonalitic arc magmatism, ranging from gabbroid to granitoid intrusives, and volcanics;
Carribean phase: collisional event.
Timeline of major Caribbean events. Abbreviations: MORB=Mid Ocean Ridge; OIB=Ocean Islands Basalt; IAT=Island Arc Tholeiite; CA=Island Arc Calcalkaline
The acquired facts and the open problems are necessary leading whatever discussion on the Caribbean puzzle reconstruction.
From the Jurassic-Early Cretaceous until the Present times, the Plate evolution was realized through spreading or plume, accretionary and collisional tectonics, dominated by a strongly oblique tectonic regime, constraining seafloor spreading, subduction, crustal exhumation, emplacement, and dismembering processes, the evidence of which has been recorded in the oceanic remnants of a lost Large Igneous Province (LIP).
We describe the main steps of the Caribbean Plate evolutionary history, stressing much more the unresolved problems than the acquired ones.
The proto-Caribbean oceanization has been realized through three steps, as the rifting of continental margins, the oceanization “strictu sensu”, and the oceanic plateau thickening.
Firstly, the South and North American continental plates developed rifting and tholeiitic magmatism, which created space for the “proto-Caribbean” oceanic domain.
The oceanic crust was generated at multiple spreading centres during the Jurassic and Early Cretaceous, forming the “proto-Caribbean” ocean. During the Cretaceous, part of that crustal domain thickened into an oceanic plateau, of petrologic Mid-Ocean Ridge (MOR) to Ocean Island Basalt (OIB) affinity (Fig.6).
Starting from Jurassic, tensional and transtensional stress-fields related to the central Atlantic opening and induced by separation of the North (NOAM) and the South (SOAM) American Plates, produced several spreading centers, offset by transform faults, developed in mid-American areas, leading to a proto-Caribbean oceanic realm between the Central Atlantic and Pacific Farallon Plate. Its accretion was initially related to multiple spreading centres (LREE-depleted MORB, in Venezuela, Costa Rica, Cuba, Guatemala, Hispaniola), evolving during the Cretaceous to a thickened oceanic plateau in its westernmost ending (REE-flat MORB locally associated with picrites, in Costa Rica, Hispaniola, Venezuela, Dutch and Venezuelan Islands). Geological evidences from Guatemala, Cuba, Hispaniola, and Venezuela strongly suggest a spatial continuity of this oceanic domain with the Bahamas, Maya and Chortis continental margins to the north, and the Guayana shield to the south, through rifted continental margins with WPT magmatism inferred in both the northern and southern peri-Caribbean belts. How many ophiolitic units can be referred to the unthickned oceanic proto Caribbean crust is difficult to establish because several data suggest that some units should better fit an intra- or back-arc supra-subduction (SSZ) origin. In any case, the near American point of view already put forward by several authors (Beccaluva et al., 1996; 1999; Meschede & Frisch, 1998; Giunta, 1993; Giunta et al., 2002 a, 2002b), is therefore favoured with respect to the classic hypothesis of the Caribbean Plate as a “Pacific promontory” (Burke, 1988; Draper & Pindell 2006; Duncan & Hargrave, 1984; Maresch et al., 2009; Pindell & Barrett, 1990; Pindell 2003; Stanek & Maresch 2006, 2009) (Fig.7).
In order to compare the various models of the literature (James, 2009 and references therein; lavori vari), some problems need a better resolution for this tectonic phase:
1. Original location of the proto-Caribbean: three models are possible as (i) Pacific origin; (ii) in situ origin; (iii) near mid-American origin. The most accepted Pacific origin sometime implies a very far original location from Central America, opposite to the in situ model which considers the proto-Caribbean ocean formed in the same place of today. In the palaeo-geographic reconstruction results almost clearly that the proto-Caribbean represented a by-pass between Atlantic and Pacific Jurassic oceans, then the near mid-American location seems to be the best choose resolving this problem, even if their growth steps and size are poorly known.
Main units related to continental margin, rifted continental margin (WPT), Proto-Caribbean ocean (MOR) and Proto-Caribbean ocean plateau (MOR to OIB). For more details and captions see also
2. From the above mentioned controversy derives the problem of the real extension of the proto-Caribbean realm; being impossible to restore the volume of the subduced oceanic lithosphere.
3. The thickening of proto-Caribbean crust, of MOR oceanic to OIB plateau began later in the Late Jurassic (?) early Cretaceous by the repeated plume events. From the paleogeographic point of view the models differ particularly on the location of the thickening: - the “Pacific ” model foresees the thin oceanic crust in a mid-American location connecting by rifting the Atlantic and Pacific ocean, whereas places the proto-Caribbean plateau far from it, offshore from the South America, thus separating both elements in term of space and time; - the in situ model considers that the thickening occurred all above the thin oceanic crust; - the near mid-American model, on the contrary, infers the thickening of the westernmost portion of the thin oceanic crust.
In all cases it is not clear the original relationships between thin and thickened crusts. Even if all models agree to compare the proto-Caribbean plateau portion with Ontong-Java plateau of the western Pacific, the major discussion, depending from the location, concerns the significance of the term proto-Caribbean, because for examplein the “Pacific” model it would be only the plateau, located far from the central American regions.
4. An other important controversy concerns the physical original relationships between the proto-Caribbean and the continental margins. Even if the rifting of the continental margin, corresponding to some tectonic units, seems to be demonstrated it is not generally accepted, because several authors consider these units as oceanic and not as sub-continental. The last case places the possibility of the original location of the proto-Caribbean ocean very close to continental margin, then in a near mid-American location.
Petrological and tectonic regional correlations suggest that the “proto-Caribbean” crust was involved into two main stages of subduction, referred to as first and second “eo- Caribbean” stages of Giunta (1993).
These two main stages of intra-oceanic subduction, marked by formation of supra-subduction igneous and metamorphic complexes, have been recognized in several Cretaceous ophiolitic units of the peri-Caribbean deformed terranes.
This period corresponds to the beginning of the compressional conditions in central America area characterized by intraoceanic subduction systems with associated IAT and CA arc magmatism, and in places sub-continental.
Starting from the Early Cretaceous, the South Atlantic opening and related westward and north-westward motion of the American plates led to ocean-ocean and ocean-continent intra/or plate convergences, producing several SSZ and magmatic arcs. Remnants of magmatic arcs and subduction complexes are represented by mantle rocks, intrusives, and volcanic sequences (Giunta et al., 2002a, 2002b, 2002c, 2002d) of: (1) the Sierra Santa Cruz (SSC), Juan de Paz (JPZ), and Baja Verapaz units (Guatemala), the Cretaceous Arc (AC) and Mabujina (MU) units (Cuba), as well as in Jamaica, to the north; (2) the Villa de Cura (VC), Dos Hermanas (DH), and Franja Costera (FC) units (Venezuela), to the south (Fig.8).
Tentative paleogeografic reconstruction and kinematic evolution of the Caribbean Plate, from Late Jurassic to Early Cretaceous (modified from
The involvement of the proto-Caribbean oceanic lithosphere in subduction zones is also demonstrated by the HP/LT metamorphosed units, outcropping in the peri-Caribbean terranes, related to an ocean-ocean subduction or subordinately to an ocean-continent subduction. Moreover, portions of the previously rifted continental margins were also involved in the subduction zones, reaching in places the eclogite facies. On the whole, several geological evidences indicate the contemporaneous presence of two subduction settings developed in an intra-oceanic convergence the first and in a sub-continental setting the latter.
Main units related to 1^ eo-Caribbean SSZ and volcanic arc (IAT to CA). ). For more details and captions see also
The first “eo-Caribbean” phase reconstruction (Fig.9) encounters several problems, the solutions of which not sufficiently supported by the data, are object of the researches of the last years in particular: a) relationships between thin and thickened oceanic crusts; b) locations of either ocean-ocean or ocean-continent convergences; c) subduction directions of the oceanic slab, if eastward or westward; d) how many arc portions can be recognized, not well defined as one single arc; e) ocean floor or back-arc pertinence of the MOR-type ophiolitic units; f) both the volcanic arc complexes and thinned continental crusts involvement in subduction zones; g) no subduction related magmatism has been found in the sub-continental subduction.
Tentative paleogeografic reconstruction and kinematic evolution of the Caribbean Plate, during middle- Late Cretaceous (modified from
Reviewing the different available models the convergence has the characteristics of an intra-oceanic subduction that is likely supposed to affect the eastern sector of the proto-Caribbean domain, where the thinner portions of the oceanic lithosphere were in more favorable conditions to be subducted, while at the same time the western sector was undergoing progressive crustal thickening, ultimately (Late Cretaceous) leading to a well defined oceanic plateau structure (Fig.10).
Main units related to 2^ eo-Caribbean volcanic arc (GR). For more details see also
The location of these intra-oceanic convergence has been inferred either in intra-middle American area or within the eastern Pacific one, both able to produce cordilleran-like ophiolites and volcanic arcs, in turn involved in subduction zone, with the subduction direction of the slab either eastward or westward.
The consequences of these various scenarios could be firstly the onset and growth of the so-called Great Volcanic Arc and also its relationships with thickening oceanic plateau, if close to the subduction trench or far from it, as placed in the different models.
It is unlikely that the Great Volcanic Arc began its activity at that time, while at the moment there are several difficulties to connect the recognized portions of volcanic arc in a continues one. From the palaeo-geographic point of view is also not clear the relationship between the ocean-ocean and the ocean-continent convergences in some areas, as for example the northern Venezuela: at least three models can be proposed, depending on some strike-slip faults playing as free boundaries between the different geodynamic environments differing from the strike-slip fault locations, dividing subduction areas with either opposite dipping directions or very complicated paleogeographical morphology.
Moreover, the metamorphism of the ophiolitic rocks demonstrates that it ranges until the eclogitic phases, in relatively fast span of time, also followed by the involvement in the subduction slab of portions of the volcanic arc and in places rifted continental margins both ranging eclogitic phases. HP-LT assemblages (blueschist and eclogitic) in both oceanic and continental lithospheres require a geodynamic model where these both oceanic and continental lithospheres have been deeply involved in the subduction zones. The development of HP-LT conditions in MORB-type units is commonly related to the subduction of dense oceanic lithosphere, in either sub-continental or intra-oceanic settings. The metamorphism of units that represent remnants of continental margin requires more complex subduction mechanisms (e.g., continental collision, tectonic erosion) that include underthrusting of more or less thinned continental crust. Moreover, the atypical evolution of the early volcanic arc should be resolved (tectonic erosion?), because some arc units (in Cuba and Venezuela) were deeply subducted and early affected by blueschist facies metamorphism. The supra subduction zone complexes generally obduce, floating and escaping from involvement in the deep part of the subduction slab; only a amphibolitic sole often develops in a narrow zone below the obducing, relatively hot, slab.
An other problem is the un-established pertinence of the MOR-type ophiolitics rocks if at an original ocean floor or back-arc systems which could help the solution of the problem of the subduction slab direction. The whole geological data confirm that the first “eo-Caribbean” accretionary stage ends in the Late Cretaceous, when the un-thickened oceanic crust was involved in subduction below the thicker oceanic plateau, with a likely westward sinking of the lithospheric slab corresponding with the more likely onset of the Great Volvanic Arcs system.
During the second eo-Caribbean stage, (Late Cretaceous) a new intraoceanic subduction took place, giving rise to (1) the widespread tonalitic arc magmatism of the northern and southern Caribbean plate margins (in Guatemala, Cuba, Hispaniola, Puerto Rico and Venezuela), (2) the HP/LT and amphibolitic metamorphic effects in both the ophiolitic units and continental margins (Cuba, Hispaniola and Puerto Rico) (Fig.11), as well as (3) the onset of the Aves/Lesser Antilles magmatic arc system, and the evolution of portions of magmatic arc facing the Middle American trench.
Since the Late Cretaceous, the kinematics of the Caribbean plate is closely related to the eastward drifting of the “proto-Caribbean” oceanic plateau (Colombia and Venezuela Basins), producing both the subduction of the oceanic lithosphere beneath the oceanic plateau and the previous magmatic arcs, and associated diachronous tonalitic magmatism.
This corresponds to the onset of the Aves - Lesser Antilles arc system, in the central part of the so-called Great Volcanic Arc, connected with a westward dipping strongly oblique subduction of the proto-Caribbean-Atlantic ocean floor below the plateau, and an opposite dismembering of subduction complexes of different ages along an E-W trend (north and south Caribbean margins) (Fig.12).
Main units related to 2^ eo-Caribbean volcanic arc (GR). For more details and captions see also
This event corresponds to the onset of the Aves - Lesser Antilles arc system, in the central part of the so-called Great Volcanic Arc, connected with a westward dipping strongly oblique subduction of the proto-Caribbean-Atlantic ocean floor below the plateau, and an opposite dismembering of subduction complexes of different ages along an E-W trend (north and south Caribbean margins) (Fig.12)
A very detailed and more accepted reconstruction of the Late Cretaceous Caribbean evolution necessary gets thought the following main points: a) Timing of the plateau insertion and related subduction and collisional belts; b) Flip or no flip of subduction direction; c) Diachronism of granitoid magmatism; d) Metamorphism and exhumation; e) Triple-points of junctions; f) Suture zones along collisional belts; g) Rotations of the mid-American blocks, along the Pacific subduction.
Tentative paleogeografic reconstruction and kinematic evolution of the Caribbean Plate, from Late Cretaceous to Paleocene (modified from
The age of the plateau drifting, likely related to the Late Cretaceous, has had the consequence of the onset of subduction of the proto-Caribbean thinner oceanic crust below the Caribbean plateau itself, presumably with the westward direction. In the interpreting model the first “eo-Caribbean” subduction eastward could be necessary a flip of subduction direction from the first to the second “eo-Caribbean” stage. The subduction system (Fig.13) connected with the Great Volcanic Arc has been realized in a very strong transpressional tectonic regime, more and more increasing from the central toward the ending of the arc, constraining also the collisional belts building from west to east.
Second eo-Caribbean phase (Late Cretaceous): generalized cross-section across the northern Caribbean accretionary system
The related metamorphism and deformation more or less fit in age and geometry this scenario, also constraining the exhumation of the metamorphic or poli-matamorphic units, followed by emplacement in the collisional belts forming very complex suture zones. In the peri-Caribbean metamorphic units are generally present two main deformation geometries, the first showing a syn-metamorphic foliation associated to a mineral lineation and rare rootless isoclinal fold; the second by a new well developed foliation and isoclinal folds acquired under retrograde metamorphic conditions. These geometries are followed by a widespread crenulation cleavage connected with open to tight folds, normally without important metamorphic imprint. At that time, several problems exist mainly related to the northern, southern and western plate margins as shown ahead. The present-day trending of the structural lineations suggests that displacement during early stage of the exhumation was high angle with respect to the subduction direction, as well as roughly parallel to the plate boundary between the Caribbean plate and both the NOAM and SOAM. Moreover, a complex decompression evolution is recorded in several HP/LT metamorphic units; the deformation phases, developed under P-T retrograde conditions during exhumation, demonstrate that the uplifting was characterized by a well developed ductile geometries.
As above mentioned, the second “eo-Caribbean” phase has been strictly related to insertion in Central American area of the proto-Caribbean plateau producing the Great Volcanic Arc activity, running from north to south, including the Aves Lesser Antilles onset.
The model that shifting of the triple-points of junctions from west to east could be demonstrated, also by the diachronism of tonalitic and granodioritic plutonism, intruding the northern and southern plate margins.
Transpressional tectonics along the northern and southern margins of the Caribbean plate caused the lateral dispersion and opposite rotation (sinistral vs. dextral, respectively) of the older structural elements. This resulted in significant differences between the two margins. Along the northern margin the younger (tonalitic) magmatic arc generally rests on the deformed belt, which includes both the older arc systems and the eastward migrating front of the new accretionary wedges. The Paleocene-Eocene volcanic arc in eastern Cuba (Sierra Maestra) may be related with a second-order shifting of a triple-point of junction southeastward, while the Late Cretaceous arc connected to the northwestern one already collided against the NOAM, becoming inactive. Along the southern margins the tonalitic magmatism is decoupled from the older arc, being intruded in both undeformed and deformed oceanic plateau and in part in the rifted continental margin units.
Moreover, the developing of the subduction of the Pacific crust below the Caribbean Plateau could have induced different rate rotations in the Central America blocks, more and more building the present-day arrangement, involving in accretionary wedges portion of the Caribbean Plateau, obducing westward and southwestward the Pacific crust.
The end of the eo-Caribbean accretionary phase is progressively older going westward marking the Late Cretaceous-Paleogene collision and/or obduction of the proto- and eo-Caribbean ophiolitic units against or onto the NOAM and SOAM continental margins, as suture zones in flake and wedge geometry. These structural features can be explained in a strike-slip tectonic regime which has largely ruled the geodynamics of the Caribbean boundaries, controlling their evolution since at least the beginning of exhumation of the HP-LT units in the mid-Late Cretaceous.
The Late Cretaceous-to-Present geodynamics of the Caribbean plate has been mainly driven by the further eastward drift of the Caribbean plateau with respect to the North and South America plates, with the consequence that it has been trapped in the Colombia and Venezuela basins by the intervening Atlantic and Pacific subductions and related volcanic arcs, producing eastward the Aves-Lesser Antilles arc, and westward the Central American Isthmus as a mosaic of different blocks reciprocally juxtaposed and facing the Middle American Trench (Fig.14).
Tentative paleogeografic reconstruction and kinematic evolution of the Caribbean Plate, from Oligocene to Present (modified from
This seems to be the consequence of the eastward shifting of both northern and southern triple junctions, allowing to the progressive bending of the Aves- Lesser Antilles arc (Fig.15).
Tentative evolutionary models for the northern and southern Caribbean Plate Margins since the Late Cretaceous, related to the eastward shifting of two triple-junctions (modified from
Westward, the Caribbean oceanic plateau was trapped by different rotation rates of the Chortis, Chorotega and Choco blocks during the construction of the western plate margin (Fig.16) (Central American Isthmus).
As a result, both the northern (Fig.17) and southern (Fig.18) boundaries of the Caribbean correspond, since the Late Cretaceous, to two wide shear zones, where, during Late Cretaceous-Tertiary, large-scale tear faulting, still extensively active and seismogenic (e.g., Motagua fault in Guatemala, El Pilar fault in Venezuela), favoured eastward dispersion and uplifting of the previous subduction accretion systems.
Western boundaries of Caribbean
During the collisional events the main structural elements (terranes) of the present-day Caribbean were essentially established in the Paleocene onwards. Fore-or back-arc and piggy-back basins, on the deforming plate borders, were filled by clastic sediments and volcanoclastics. On the northern and southern continental margins, thrust belt-foredeep couples began to develop, involving previously deformed terranes along north- or south-verging fronts (Sepur Basin in Mexico-Guatemala; Foreland Basin in Cuba; Piemontine Basin in Venezuela).
The main controversy related to the collisional event are focused on the architecture of the deformed marginal belts, restoring then in a regional correlation way, especially through a detailed reconstruction of the deformation fronts evolution.
Sketches illustrating the northern Caribbean plate margin reconstruction in (upper) the Late Cretaceous– Paleocene, and during (lower) the Tertiary. The diachronic tonalitic magmatic arc generally rests on both the older arc systems and the oceanic plateau, contemporaneously to the progressive north-eastward migration of the accretionary wedge front, followed from the west by suture zones related to triple junctions.Numbers in legend: 1: Caribbean Oceanic plateau. 2: Accretionary wedge front. 3: Diachronic tonalitic magmatism arc. 4: Older arc systems. 5: Triple-junctions
Sketches illustrating the southern Caribbean plate margin reconstruction in the (A) Late Cretaceous– Paleocene, and during (B) the Paleogene. Numbers in legend: 1: Caribbean Oceanic plateau. 2: Proto-Caribbean-Atlantic oceanic crust. 3: Rifted continental margins. 4: Tonalitic magmatism arc. 5: Older arc systems. 6: Triple-junctions
At the moment, even if the acquired facts can be considered enough for an evolution outline, a lot of different order problems remain open or insufficiently explained, so that the related models seem to be far too speculative (Giunta & Oliveri, 2009).
However, we tried to resolve some of these problems; taking into account different possibilities based on the results of the discussions until today:
1. The original location of the proto-Caribbean oceanic realm; maybe by-pass between Atlantic and Pacific, as westward prosecution of the Tethyan ocean;
2. The Early Cretaceous paleogeography and morphology of the continental margins of NOAM, SOAM and minor blocks, as rifted continental margins close to the oceanic realm;
3. The number and location of magmatic arc events, maybe related to both 1^ eo-Caribbean (mid-Cretaceous), involving thin oceanic crust, and 2^ eo-Caribbean (Late Cretaceous), involving oceanic crust below the plateau;
4. The polarity of the Cretaceous subduction slabs, and possibility of subduction polarity reversal, can be resolved following two models, (i) Eastward in the 1^ eo-Caribb. and westward in the 2^ eo-Caribb., with flip of subduction polarity; or (ii) Westward in both the 1^ and 2^ eo-Caribb. phases;
5. The locations of and relationships between simultaneous intraoceanic and subcontinental subduction zones (1^ eo-Caribbean phase), could be resolved through different subduction sectors connected by free-boundaries;
6. The different characteristics of Supra Subduction Zones and volcanic arcs related to 1^ eo-Caribbean stage, including back-arcs or trapped crusts, and to 2^ eo-Caribbean stage in particularly in northern and southern margins;
7. The onset and growth of the so-called Great Volcanic Arc, if active since the Early-mid Cretaceous and coming from Pacific areas, or connected to the Late Cretaceous-Tertiary subduction (2° eo-Caribbean stage and collisional event), more and more bending eastward.
8. The progressive insertion in subduction of both rifted continental portions and suprasubduction complexes, probably induced by tectonic erosion related with strongly oblique subduction slabs;
9. The timing and characteristic of metamorphic deformation and exhumation: at the moment have been recognized differences of PT-t path in 1^ and 2^ eo-Caribbean phases even if associated with two ductile deformation related to the metamorphism and one or two related to exhumation, all in a strike-slip tectonic regime;
10. The evolution of the collisional belts (Late Cretaceous-Tertiary), almost resolved with two triple points of junction progressively shifting eastward, and increasing the strike-slip tectonics.
11. The relationships between Caribbean Plate and northern ending of the Andes, at the moment almost unknown, i.e. due to the different significance of the Romeral belt of Colombia (plateau or SSZ ?).
A number of these open-problems will be discussed in this paper, taking into account the recent researches and models, proposed in a multi-disciplinary point of view, in the aim to improve the knowledge of the Caribbean Plate tectonics.
Microbes are ubiquitous in nature and humans are no exception. Microbes have coevolved with humans and reside in and on human body to develop a host associated structure, called “Human Microbiome” or “Human Microbiota.” These microbial counterparts account toward 10% of human body weight and outnumber human cells by approximately by tenfold and considered as commensals. Human microbiome is defined as the total genomes of microbes (constitute bacteria, bacteriophage, fungi, protozoa and viruses) that live inside or on the human body [1]. There are trillions of microbes living in/on human body plays a fundamental role in normal functioning of metabolic, physiological and immune system. Microbiota is a complex ecosystem consisting of bacteria, protozoa, viruses and fungi; all varies in number even in body parts of same individual. Human body has 10 times more bacteria than the number of human cells in our body [2]. Most of these bacteria are present in gastrointestinal tract [3] which account for approximate 70% of the total microbial load in or on human body (particular in large intestine) [4]. Humans are born sterile and start acquiring human companion to shape resilient microbiome structure. Establishment of microbiome starts with birth and matures with age. Microbial introduction and the establishment of microbiome is a random process influenced by many factor like mode of delivery, diet, sex, age, genetics, geographical location have a strong impact in shaping human microbiome structure [5, 6, 7, 8, 9, 10]. These microbes are in symbiotic relationship, beside gut they are also found in mouth, respiratory tract, vagina and skin.
The study of human microbiome diversity started with Antonie Van Leeuwenhoek, when he had a comparison of his oral and fecal microbiota in 1680s. He found that different microbes are present in different habitats and also different microbes are present in healthy and diseased person [11, 12]. There is a growing evidence that any change in microbiota composition leads to several metabolic diseases including obesity, diabetes and cardiovascular. Different parts of intestinal tract have different composition of microbes and it varies according to age, weight, site and diet. Composition of microbiota in gut alters by nutrition, drugs, diet and genetic background and lifestyle. Microbiota regulates metabolic and physiological mechanisms by producing metabolites. It has been found out that different species of microbiota in gut works under same metabolic pathway [9]. Qualitative and quantitative alteration in gut microbiota leads to dysbiosis by consuming antibiotics, physical and psychological stress [13]. Recent studies shows evidence regarding change in composition by urban and rural environment, affects skin (allergic symptoms) of particular organisms. Age alter the environmental effects on individual such as alter microbiota variations in skin between children and teenager cause skin allergies [14]. Microbiome structure varies in respect of host anatomical and physiological sites. Normally, flora found in/on the body surface in stable condition to compete with pathogenic microbes in environment or those microbes entered in specific body parts [15]. As in addition to these permanent residents, a number of microbes known as causative agent for various infectious diseases. Likewise commensals, these infectious agents have evolved an efficient machinery to evade host protective gears for their successful proliferation in various anatomical locations. Normal bacteria defend host against the invasion of pathogenic microorganisms by inducing barrier against them [16]. It was observed that host commensals plays a critical role in balancing the abundance of pathogenic and nonpathogenic microbial strains and protects the host form the onset of any infectious diseases. However a number of factors like change in diet, variable host immune response, fluctuating environmental conditions like pH, oxygen saturation, ionic strength, etc., could induce microbial dysbiosis and induce microbial community dynamics. These microbial community dynamics could induce favorable conditions for growth of earlier dormant pathogenic microbes and result in onset of infectious diseases [16].
Microbes have been identified to play a vital role in human health and diseases. Physiological characterization of these microbes and defining their functional molecular machinery could enable us to develop potential therapeutic and diagnostic targets. Additionally, holistic overview of human microbiome structure, human microbe interactions and role of microbes in human health and diseases are the key areas of current research focus. In-depth information about host microbial interaction in human health and diseases could enable to identify causative factors for development of host physiological/metabolic disorders. Current book comprises of various chapters defining a relation among human and microbes in health and diseases.
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\\n\\nThe Author and Co-Authors also confirm and warrant that: (i) he/she has the power to enter into this Publication Agreement on his or her own behalf and on behalf of each Co-Author; and (ii) has the necessary rights and/or title in and to the Work to grant IntechOpen, on behalf of themselves and any Co-Author, the rights and licences in this Publication Agreement. If the Work was prepared jointly by the Author and Co-Authors, the Author confirms that: (i) all Co-Authors agree to the submission, license and publication of the Work on the terms of this Publication Agreement; and (ii) the Author has the authority to enter into this biding Publication Agreement on behalf of each Co-Author. The Author shall: (i) ensure each Co-Author complies with all relevant provisions of this Publication Agreement, including those relating to confidentiality, performance and standards, as if a party to this Publication Agreement; and (ii) remain primarily liable for all acts and/or omissions of each Co-Author.
\\n\\nThe Author agrees to indemnify IntechOpen harmless against all liabilities, costs, expenses, damages and losses, as well as all reasonable legal costs and expenses suffered or incurred by IntechOpen arising out of, or in connection with, any breach of the agreed confirmations and warranties. This indemnity shall not apply in a situation in which a claim results from IntechOpen's negligence or willful misconduct.
\\n\\nNothing in this Publication Agreement shall have the effect of excluding or limiting any liability for death or personal injury caused by negligence or any other liability that cannot be excluded or limited by applicable law.
\\n\\nTERMINATION
\\n\\nIntechOpen has the right to terminate this Publication Agreement for quality, program, technical or other reasons with immediate effect, including without limitation (i) if the Author and/or any Co-Author commits a material breach of this Publication Agreement; (ii) if the Author and/or any Co-Author (being a private individual) is the subject of a bankruptcy petition, application or order; or (iii) if the Author and/or any Co-Author (as a corporate entity) commences negotiations with all or any class of its creditors with a view to rescheduling any of its debts, or makes a proposal for, or enters into, any compromise or arrangement with any of its creditors.
\\n\\nIn the event of termination, IntechOpen will notify the Author of the decision in writing.
\\n\\nIntechOpen’s DUTIES AND RIGHTS
\\n\\nUnless prevented from doing so by events beyond its reasonable control, IntechOpen, at its discretion, agrees to publish the Work attributing it to the Author and Co-Authors.
\\n\\nUnless prevented from doing so by events beyond its reasonable control, IntechOpen agrees to provide publishing services which include: managing editing (editorial and publishing process coordination, Author assistance); publishing software technology; language copyediting; typesetting; online publishing; hosting and web management; and abstracting and indexing services.
\\n\\nIntechOpen agrees to offer free online access to readers and use reasonable efforts to promote the Publication to relevant audiences.
\\n\\nIntechOpen is granted the authority to enforce the rights from this Publication Agreement on behalf of the Author and Co-Authors against third parties, for example in cases of plagiarism or copyright infringements. In respect of any such infringement or suspected infringement of the copyright in the Work, IntechOpen shall have absolute discretion in addressing any such infringement that is likely to affect IntechOpen's rights under this Publication Agreement, including issuing and conducting proceedings against the suspected infringer.
\\n\\nIntechOpen has the right to include/use the Author and Co-Authors names and likeness in connection with scientific dissemination, retrieval, archiving, web hosting and promotion and marketing of the Work and has the right to contact the Author and Co-Authors until the Work is publicly available on any platform owned and/or operated by IntechOpen.
\\n\\nMISCELLANEOUS
\\n\\nFurther Assurance: The Author shall ensure that any relevant third party, including any Co-Author, shall execute and deliver whatever further documents or deeds and perform such acts as IntechOpen reasonably requires from time to time for the purpose of giving IntechOpen the full benefit of the provisions of this Publication Agreement.
\\n\\nThird Party Rights: A person who is not a party to this Publication Agreement may not enforce any of its provisions under the Contracts (Rights of Third Parties) Act 1999.
\\n\\nEntire Agreement: This Publication Agreement constitutes the entire agreement between the parties in relation to its subject matter. It replaces all prior agreements, draft agreements, arrangements, collateral warranties, collateral contracts, statements, assurances, representations and undertakings of any nature made by, or on behalf of, the parties, whether oral or written, in relation to that subject matter. Each party acknowledges that in entering into this Publication Agreement it has not relied upon any oral or written statements, collateral or other warranties, assurances, representations or undertakings which were made by or on behalf of the other party in relation to the subject matter of this Publication Agreement at any time before its signature (known as the "Pre-Contractual Statements"), other than those which are set out in this Publication Agreement. Each party hereby waives all rights and remedies which might otherwise be available to it in relation to such Pre-Contractual Statements. Nothing in this clause shall exclude or restrict the liability of either party arising out of any fraudulent pre-contract misrepresentation or concealment.
\\n\\nWaiver: No failure or delay by a party to exercise any right or remedy provided under this Publication Agreement or by law shall constitute a waiver of that or any other right or remedy, nor shall it preclude or restrict the further exercise of that or any other right or remedy. No single or partial exercise of such right or remedy shall preclude or restrict the further exercise of that or any other right or remedy.
\\n\\nVariation: No variation of this Publication Agreement shall have effect unless it is in writing and signed by the parties, or their duly authorized representatives.
\\n\\nSeverance: If any provision, or part-provision, of this Publication Agreement is, or becomes invalid, illegal or unenforceable, it shall be deemed modified to the minimum extent necessary to make it valid, legal and enforceable. If such modification is not possible, the relevant provision or part-provision shall be deemed deleted. Any modification to, or deletion of, a provision or part-provision under this clause shall not affect the validity and enforceability of the rest of this Publication Agreement.
\\n\\nNo partnership: Nothing in this Publication Agreement is intended to, or shall be deemed to, establish or create any partnership or joint venture or the relationship of principal and agent or employer and employee between IntechOpen and the Author or any Co-Author, nor authorize any party to make or enter into any commitments for, or on behalf of, any other party.
\\n\\nGoverning law: This Publication Agreement and any dispute or claim, including non-contractual disputes or claims arising out of, or in connection with it, or its subject matter or formation, shall be governed by and construed in accordance with the law of England and Wales. The parties submit to the exclusive jurisdiction of the English courts to settle any dispute or claim arising out of, or in connection with, this Publication Agreement, including any non-contractual disputes or claims.
\\n\\nPolicy last updated: 2018-09-11
\\n"}]'},components:[{type:"htmlEditorComponent",content:'When submitting a manuscript, the Author is required to accept the Terms and Conditions set out in our Publication Agreement – Monographs/Compacts as follows:
\n\nCORRESPONDING AUTHOR'S GRANT OF RIGHTS
\n\nSubject to the following Article, the Author grants to IntechOpen, during the full term of copyright, and any extensions or renewals of that term, the following:
\n\nThe foregoing licenses shall survive the expiry or termination of this Publication Agreement for any reason.
\n\nThe Author, on his or her own behalf and on behalf of any of the Co-Authors, reserves the following rights in the Work but agrees not to exercise them in such a way as to adversely affect IntechOpen's ability to utilize the full benefit of this Publication Agreement: (i) reprographic rights worldwide, other than those which subsist in the typographical arrangement of the Work as published by IntechOpen; and (ii) public lending rights arising under the Public Lending Right Act 1979, as amended from time to time, and any similar rights arising in any part of the world.
\n\nThe Author, and any Co-Author, confirms that they are, and will remain, a member of any applicable licensing and collecting society and any successor to that body responsible for administering royalties for the reprographic reproduction of copyright works.
\n\nSubject to the license granted above, copyright in the Work and all versions of it created during IntechOpen's editing process, including all published versions, is retained by the Author and any Co-Authors.
\n\nSubject to the license granted above, the Author and Co-Authors retain patent, trademark and other intellectual property rights to the Work.
\n\nAll rights granted to IntechOpen in this Article are assignable, sublicensable or otherwise transferrable to third parties without the specific approval of the Author or Co-Authors.
\n\nThe Author, on his/her own behalf and on behalf of the Co-Authors, will not assert any rights under the Copyright, Designs and Patents Act 1988 to object to derogatory treatment of the Work as a consequence of IntechOpen's changes to the Work arising from the translation of it, corrections and edits for house style, removal of problematic material and other reasonable edits as determined by IntechOpen.
\n\nAUTHOR'S DUTIES
\n\nWhen distributing or re-publishing the Work, the Author agrees to credit the Monograph/Compacts as the source of first publication, as well as IntechOpen. The Author guarantees that Co-Authors will also credit the Monograph/Compacts as the source of first publication, as well as IntechOpen, when they are distributing or re-publishing the Work.
\n\nThe Author agrees to:
\n\nThe Author will be held responsible for the payment of the agreed Open Access Publishing Fee before the completion of the project (Monograph/Compacts publication).
\n\nAll payments shall be due 30 days from the date of issue of the invoice. The Author or whoever is paying on behalf of the Author and Co-Authors will bear all banking and similar charges incurred.
\n\nThe Author shall obtain in writing all consents necessary for the reproduction of any material in which a third-party right exists, including quotations, photographs and illustrations, in all editions of the Work worldwide for the full term of the above licenses, and shall provide to IntechOpen, at its request, the original copies of such consents for inspection or the photocopies of such consents.
\n\nThe Author shall obtain written informed consent for publication from those who might recognize themselves or be identified by others, for example from case reports or photographs.
\n\nThe Author shall respect confidentiality during and after the termination of this Agreement. The information contained in all correspondence and documents as part of the publishing activity between IntechOpen and the Author and Co-Authors are confidential and are intended only for the recipients. The contents of any communication may not be disclosed publicly and are not intended for unauthorized use or distribution. Any use, disclosure, copying, or distribution is prohibited and may be unlawful.
\n\nAUTHOR'S WARRANTY
\n\nThe Author and Co-Authors confirm and warrant that the Work does not and will not breach any applicable law or the rights of any third party and, specifically, that the Work contains no matter that is defamatory or that infringes any literary or proprietary rights, intellectual property rights, or any rights of privacy.
\n\nThe Author and Co-Authors confirm that: (i) the Work is their original work and is not copied wholly or substantially from any other work or material or any other source; (ii) the Work has not been formally published in any other peer-reviewed journal or in a book or edited collection, and is not under consideration for any such publication; (iii) Authors and any applicable Co-Authors are qualifying persons under section 154 of the Copyright, Designs and Patents Act 1988; (iv) Authors and any applicable Co-Authors have not assigned, and will not during the term of this Publication Agreement purport to assign, any of the rights granted to IntechOpen under this Publication Agreement; and (v) the rights granted by this Publication Agreement are free from any security interest, option, mortgage, charge or lien.
\n\nThe Author and Co-Authors also confirm and warrant that: (i) he/she has the power to enter into this Publication Agreement on his or her own behalf and on behalf of each Co-Author; and (ii) has the necessary rights and/or title in and to the Work to grant IntechOpen, on behalf of themselves and any Co-Author, the rights and licences in this Publication Agreement. If the Work was prepared jointly by the Author and Co-Authors, the Author confirms that: (i) all Co-Authors agree to the submission, license and publication of the Work on the terms of this Publication Agreement; and (ii) the Author has the authority to enter into this biding Publication Agreement on behalf of each Co-Author. The Author shall: (i) ensure each Co-Author complies with all relevant provisions of this Publication Agreement, including those relating to confidentiality, performance and standards, as if a party to this Publication Agreement; and (ii) remain primarily liable for all acts and/or omissions of each Co-Author.
\n\nThe Author agrees to indemnify IntechOpen harmless against all liabilities, costs, expenses, damages and losses, as well as all reasonable legal costs and expenses suffered or incurred by IntechOpen arising out of, or in connection with, any breach of the agreed confirmations and warranties. This indemnity shall not apply in a situation in which a claim results from IntechOpen's negligence or willful misconduct.
\n\nNothing in this Publication Agreement shall have the effect of excluding or limiting any liability for death or personal injury caused by negligence or any other liability that cannot be excluded or limited by applicable law.
\n\nTERMINATION
\n\nIntechOpen has the right to terminate this Publication Agreement for quality, program, technical or other reasons with immediate effect, including without limitation (i) if the Author and/or any Co-Author commits a material breach of this Publication Agreement; (ii) if the Author and/or any Co-Author (being a private individual) is the subject of a bankruptcy petition, application or order; or (iii) if the Author and/or any Co-Author (as a corporate entity) commences negotiations with all or any class of its creditors with a view to rescheduling any of its debts, or makes a proposal for, or enters into, any compromise or arrangement with any of its creditors.
\n\nIn the event of termination, IntechOpen will notify the Author of the decision in writing.
\n\nIntechOpen’s DUTIES AND RIGHTS
\n\nUnless prevented from doing so by events beyond its reasonable control, IntechOpen, at its discretion, agrees to publish the Work attributing it to the Author and Co-Authors.
\n\nUnless prevented from doing so by events beyond its reasonable control, IntechOpen agrees to provide publishing services which include: managing editing (editorial and publishing process coordination, Author assistance); publishing software technology; language copyediting; typesetting; online publishing; hosting and web management; and abstracting and indexing services.
\n\nIntechOpen agrees to offer free online access to readers and use reasonable efforts to promote the Publication to relevant audiences.
\n\nIntechOpen is granted the authority to enforce the rights from this Publication Agreement on behalf of the Author and Co-Authors against third parties, for example in cases of plagiarism or copyright infringements. In respect of any such infringement or suspected infringement of the copyright in the Work, IntechOpen shall have absolute discretion in addressing any such infringement that is likely to affect IntechOpen's rights under this Publication Agreement, including issuing and conducting proceedings against the suspected infringer.
\n\nIntechOpen has the right to include/use the Author and Co-Authors names and likeness in connection with scientific dissemination, retrieval, archiving, web hosting and promotion and marketing of the Work and has the right to contact the Author and Co-Authors until the Work is publicly available on any platform owned and/or operated by IntechOpen.
\n\nMISCELLANEOUS
\n\nFurther Assurance: The Author shall ensure that any relevant third party, including any Co-Author, shall execute and deliver whatever further documents or deeds and perform such acts as IntechOpen reasonably requires from time to time for the purpose of giving IntechOpen the full benefit of the provisions of this Publication Agreement.
\n\nThird Party Rights: A person who is not a party to this Publication Agreement may not enforce any of its provisions under the Contracts (Rights of Third Parties) Act 1999.
\n\nEntire Agreement: This Publication Agreement constitutes the entire agreement between the parties in relation to its subject matter. It replaces all prior agreements, draft agreements, arrangements, collateral warranties, collateral contracts, statements, assurances, representations and undertakings of any nature made by, or on behalf of, the parties, whether oral or written, in relation to that subject matter. Each party acknowledges that in entering into this Publication Agreement it has not relied upon any oral or written statements, collateral or other warranties, assurances, representations or undertakings which were made by or on behalf of the other party in relation to the subject matter of this Publication Agreement at any time before its signature (known as the "Pre-Contractual Statements"), other than those which are set out in this Publication Agreement. Each party hereby waives all rights and remedies which might otherwise be available to it in relation to such Pre-Contractual Statements. Nothing in this clause shall exclude or restrict the liability of either party arising out of any fraudulent pre-contract misrepresentation or concealment.
\n\nWaiver: No failure or delay by a party to exercise any right or remedy provided under this Publication Agreement or by law shall constitute a waiver of that or any other right or remedy, nor shall it preclude or restrict the further exercise of that or any other right or remedy. No single or partial exercise of such right or remedy shall preclude or restrict the further exercise of that or any other right or remedy.
\n\nVariation: No variation of this Publication Agreement shall have effect unless it is in writing and signed by the parties, or their duly authorized representatives.
\n\nSeverance: If any provision, or part-provision, of this Publication Agreement is, or becomes invalid, illegal or unenforceable, it shall be deemed modified to the minimum extent necessary to make it valid, legal and enforceable. If such modification is not possible, the relevant provision or part-provision shall be deemed deleted. Any modification to, or deletion of, a provision or part-provision under this clause shall not affect the validity and enforceability of the rest of this Publication Agreement.
\n\nNo partnership: Nothing in this Publication Agreement is intended to, or shall be deemed to, establish or create any partnership or joint venture or the relationship of principal and agent or employer and employee between IntechOpen and the Author or any Co-Author, nor authorize any party to make or enter into any commitments for, or on behalf of, any other party.
\n\nGoverning law: This Publication Agreement and any dispute or claim, including non-contractual disputes or claims arising out of, or in connection with it, or its subject matter or formation, shall be governed by and construed in accordance with the law of England and Wales. The parties submit to the exclusive jurisdiction of the English courts to settle any dispute or claim arising out of, or in connection with, this Publication Agreement, including any non-contractual disputes or claims.
\n\nPolicy last updated: 2018-09-11
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On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. 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Delac received his B.Sc.E.E. degree in 2003 and is currentlypursuing a Ph.D. degree at the University of Zagreb, Faculty of Electrical Engineering andComputing. His current research interests are digital image analysis, pattern recognition andbiometrics.",institutionString:null,institution:{name:"University of Zagreb",country:{name:"Croatia"}}},{id:"557",title:"Dr.",name:"Andon",middleName:"Venelinov",surname:"Topalov",slug:"andon-topalov",fullName:"Andon Topalov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/557/images/1927_n.jpg",biography:"Dr. Andon V. Topalov received the MSc degree in Control Engineering from the Faculty of Information Systems, Technologies, and Automation at Moscow State University of Civil Engineering (MGGU) in 1979. He then received his PhD degree in Control Engineering from the Department of Automation and Remote Control at Moscow State Mining University (MGSU), Moscow, in 1984. From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. And he has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. 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Prior to his academic appointment, Dr. Lai worked as a Senior Scientist at the Ministry of Science, Technology and Innovation, Malaysia. His current research areas include antimicrobial resistance and plant-pathogen interaction. His particular interest lies in the study of the antimicrobial mechanism via membrane disruption of essential oils against multi-drug resistance bacteria through various biochemical, molecular and proteomic approaches. 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Over the past few decades, no major new types of antibiotics have been produced and almost all known antibiotics are increasingly losing their activity against pathogenic microorganisms. The levels of multi-drug resistant bacteria have also increased. It is known that worldwide, more than 60% of all antibiotics that are produced find their use in animal production for both therapeutic and non-therapeutic purposes. The use of antimicrobial agents in animal husbandry has been linked to the development and spread of resistant bacteria. Poultry products are among the highest consumed products worldwide but a lot of essential antibiotics are employed during poultry production in several countries; threatening the safety of such products (through antimicrobial residues) and the increased possibility of development and spread of microbial resistance in poultry settings. This chapter documents some of the studies on antibiotic usage in poultry farming; with specific focus on some selected bacterial species, their economic importance to poultry farming and reports of resistances of isolated species from poultry settings (farms and poultry products) to essential antibiotics.",book:{id:"6978",slug:"antimicrobial-resistance-a-global-threat",title:"Antimicrobial Resistance",fullTitle:"Antimicrobial Resistance - A Global Threat"},signatures:"Christian Agyare, Vivian Etsiapa Boamah, Crystal Ngofi Zumbi and\nFrank Boateng Osei",authors:[{id:"182058",title:"Dr.",name:"Christian",middleName:null,surname:"Agyare",slug:"christian-agyare",fullName:"Christian Agyare"},{id:"261271",title:"MSc.",name:"Crystal Ngofi",middleName:null,surname:"Zumbi",slug:"crystal-ngofi-zumbi",fullName:"Crystal Ngofi Zumbi"},{id:"261272",title:"MSc.",name:"Frank Boateng",middleName:null,surname:"Osei",slug:"frank-boateng-osei",fullName:"Frank Boateng Osei"},{id:"261273",title:"Dr.",name:"Vivian Etsiapa",middleName:null,surname:"Boamah",slug:"vivian-etsiapa-boamah",fullName:"Vivian Etsiapa Boamah"}]},{id:"49246",doi:"10.5772/61300",title:"Chitosan as a Biomaterial — Structure, Properties, and Electrospun Nanofibers",slug:"chitosan-as-a-biomaterial-structure-properties-and-electrospun-nanofibers",totalDownloads:4727,totalCrossrefCites:27,totalDimensionsCites:63,abstract:"Chitosan is a polysaccharide derived from chitin; chitin is the second most abundant polysaccharide in the world, after cellulose. Chitosan is biocompatible, biodegradable and non-toxic, so that it can be usedin medicalapplications such as antimicrobial and wound healing biomaterials. It also used as chelating agent due to its ability to bind with cholesterol, fats, proteins and metal ions.",book:{id:"4648",slug:"concepts-compounds-and-the-alternatives-of-antibacterials",title:"Concepts, Compounds and the Alternatives of Antibacterials",fullTitle:"Concepts, Compounds and the Alternatives of Antibacterials"},signatures:"H. M. Ibrahim and E.M.R. El- Zairy",authors:[{id:"90645",title:"Dr.",name:"Hassan",middleName:null,surname:"Ibrahim",slug:"hassan-ibrahim",fullName:"Hassan Ibrahim"},{id:"175694",title:"Dr.",name:"Enas",middleName:null,surname:"El- Zairy",slug:"enas-el-zairy",fullName:"Enas El- Zairy"}]},{id:"70919",doi:"10.5772/intechopen.90891",title:"Antimicrobial Effect of Titanium Dioxide Nanoparticles",slug:"antimicrobial-effect-of-titanium-dioxide-nanoparticles",totalDownloads:1817,totalCrossrefCites:21,totalDimensionsCites:47,abstract:"The widespread use of antibiotics has led to the emergence of multidrug-resistant bacterial strains, and therefore a current concern for food safety and human health. The interest for new antimicrobial substances has been focused toward metal oxide nanoparticles. Specifically, titanium dioxide (TiO2) has been considered as an attractive antimicrobial compound due to its photocatalytic nature and because it is a chemically stable, non-toxic, inexpensive, and Generally Recognized as Safe (GRAS) substance. Several studies have revealed this metal oxide demonstrates excellent antifungal and antibacterial properties against a broad range of both Gram-positive and Gram-negative bacteria. These properties were significantly improved by titanium dioxide nanoparticles (TiO2 NPs) synthesis. In this chapter, latest developments on routes of synthesis of TiO2 NPs and antimicrobial activity of these nanostructures are presented. Furthermore, TiO2 NPs favor the inactivation of microorganisms due to their strong oxidizing power by free radical generation, such as hydroxyl and superoxide anion radicals, showing reductions growth against several microorganisms, such as Escherichia coli and Staphylococcus aureus. Understanding the main mechanisms of antimicrobial action of these nanoparticles was the second main purpose of this chapter.",book:{id:"9521",slug:"antimicrobial-resistance-a-one-health-perspective",title:"Antimicrobial Resistance",fullTitle:"Antimicrobial Resistance - A One Health Perspective"},signatures:"Carol López de Dicastillo, Matias Guerrero Correa, Fernanda B. Martínez, Camilo Streitt and Maria José Galotto",authors:[{id:"244902",title:"Dr.",name:"Carol",middleName:null,surname:"Lopez De Dicastillo",slug:"carol-lopez-de-dicastillo",fullName:"Carol Lopez De Dicastillo"},{id:"315494",title:"Mr.",name:"Matias",middleName:null,surname:"Guerrero Correa",slug:"matias-guerrero-correa",fullName:"Matias Guerrero Correa"},{id:"315495",title:"Ms.",name:"Fernanda",middleName:null,surname:"B. Martínez",slug:"fernanda-b.-martinez",fullName:"Fernanda B. Martínez"},{id:"315496",title:"Mr.",name:"Camilo",middleName:null,surname:"Zuñiga",slug:"camilo-zuniga",fullName:"Camilo Zuñiga"},{id:"315497",title:"Dr.",name:"Maria José",middleName:null,surname:"Galotto",slug:"maria-jose-galotto",fullName:"Maria José Galotto"}]},{id:"65613",doi:"10.5772/intechopen.84411",title:"The Methods for Detection of Biofilm and Screening Antibiofilm Activity of Agents",slug:"the-methods-for-detection-of-biofilm-and-screening-antibiofilm-activity-of-agents",totalDownloads:9283,totalCrossrefCites:15,totalDimensionsCites:26,abstract:"Biofilm producer microorganisms cause nosocomial and recurrent infections. Biofilm that is a sticky exopolysaccharide is the main virulence factor causing biofilm-related infections. Biofilm formation begins with attachment of bacteria to biotic surface such as host cell or abiotic surface such as prosthetic devices. After attachment, aggregation of bacteria is started by cell-cell adhesion. Aggregation continues with the maturation of biofilm. Dispersion is started by certain conditions such as phenol-soluble modulins (PSMs). By this way, sessile bacteria turn back into planktonic form. Bacteria embedded in biofilm (sessile form) are more resistant to antimicrobials than planktonic bacteria. So it is hard to treat biofilm-embedded bacteria than planktonic forms. For this reason, it is important to detect biofilm. There are a few biofilm detection and biofilm production methods on prosthetics, methods for screening antibacterial effect of agents against biofilm-embedded microorganism and antibiofilm effect of agents against biofilm production and mature biofilm. The aim of this chapter is to overview direct and indirect methods such as microscopy, fluorescent in situ hybridization, and Congo red agar, tube method, microtiter plate assay, checkerboard assay, plate counting, polymerase chain reaction, mass spectrometry, MALDI-TOF, and biological assays used by antibiofilm researches.",book:{id:"8427",slug:"antimicrobials-antibiotic-resistance-antibiofilm-strategies-and-activity-methods",title:"Antimicrobials, Antibiotic Resistance, Antibiofilm Strategies and Activity Methods",fullTitle:"Antimicrobials, Antibiotic Resistance, Antibiofilm Strategies and Activity Methods"},signatures:"Sahra Kırmusaoğlu",authors:[{id:"179460",title:"Associate Prof.",name:"Sahra",middleName:null,surname:"Kırmusaoğlu",slug:"sahra-kirmusaoglu",fullName:"Sahra Kırmusaoğlu"}]},{id:"63397",doi:"10.5772/intechopen.80624",title:"Antibiotic Resistance in Lactic Acid Bacteria",slug:"antibiotic-resistance-in-lactic-acid-bacteria",totalDownloads:2486,totalCrossrefCites:12,totalDimensionsCites:21,abstract:"Most starter cultures belong to the lactic acid bacteria group (LAB) and recognized as safe by the US Food and Drug Administration (FDA) and the European Food Safety Authority (EFSA). However, LAB may act as intrinsic or extrinsic reservoirs for antibiotic resistance (AR) genes. This fact may not constitute a safety concern itself, as the resistance gene transfer is vertical. Nevertheless, external genetic elements may induce changes that favor the horizontal transfer transmission of resistance from pathogens as well as from the human intestinal microbiota, which represents a severe safety issue. Some genus of AR LAB includes Enterococcus, Lactobacillus, Lactococcus, Leuconostoc, Pediococcus, and Streptococcus isolated from fermented meat and milk products. Currently, the WHO recommends that LAB used in the food industry should be free of resistance. Therefore, the objective of this chapter is to present an overview of the LAB antibiotic resistance and some methods to determine the same.",book:{id:"6978",slug:"antimicrobial-resistance-a-global-threat",title:"Antimicrobial Resistance",fullTitle:"Antimicrobial Resistance - A Global Threat"},signatures:"Yenizey M. Álvarez-Cisneros and Edith Ponce-Alquicira",authors:[{id:"256345",title:"Dr.",name:"Yenizey Merit",middleName:null,surname:"Alvarez Cisneros",slug:"yenizey-merit-alvarez-cisneros",fullName:"Yenizey Merit Alvarez Cisneros"},{id:"256347",title:"Dr.",name:"Edith",middleName:null,surname:"Ponce-Alquicira",slug:"edith-ponce-alquicira",fullName:"Edith Ponce-Alquicira"}]}],mostDownloadedChaptersLast30Days:[{id:"65613",title:"The Methods for Detection of Biofilm and Screening Antibiofilm Activity of Agents",slug:"the-methods-for-detection-of-biofilm-and-screening-antibiofilm-activity-of-agents",totalDownloads:9277,totalCrossrefCites:15,totalDimensionsCites:26,abstract:"Biofilm producer microorganisms cause nosocomial and recurrent infections. Biofilm that is a sticky exopolysaccharide is the main virulence factor causing biofilm-related infections. Biofilm formation begins with attachment of bacteria to biotic surface such as host cell or abiotic surface such as prosthetic devices. After attachment, aggregation of bacteria is started by cell-cell adhesion. Aggregation continues with the maturation of biofilm. Dispersion is started by certain conditions such as phenol-soluble modulins (PSMs). By this way, sessile bacteria turn back into planktonic form. Bacteria embedded in biofilm (sessile form) are more resistant to antimicrobials than planktonic bacteria. So it is hard to treat biofilm-embedded bacteria than planktonic forms. For this reason, it is important to detect biofilm. There are a few biofilm detection and biofilm production methods on prosthetics, methods for screening antibacterial effect of agents against biofilm-embedded microorganism and antibiofilm effect of agents against biofilm production and mature biofilm. The aim of this chapter is to overview direct and indirect methods such as microscopy, fluorescent in situ hybridization, and Congo red agar, tube method, microtiter plate assay, checkerboard assay, plate counting, polymerase chain reaction, mass spectrometry, MALDI-TOF, and biological assays used by antibiofilm researches.",book:{id:"8427",slug:"antimicrobials-antibiotic-resistance-antibiofilm-strategies-and-activity-methods",title:"Antimicrobials, Antibiotic Resistance, Antibiofilm Strategies and Activity Methods",fullTitle:"Antimicrobials, Antibiotic Resistance, Antibiofilm Strategies and Activity Methods"},signatures:"Sahra Kırmusaoğlu",authors:[{id:"179460",title:"Associate Prof.",name:"Sahra",middleName:null,surname:"Kırmusaoğlu",slug:"sahra-kirmusaoglu",fullName:"Sahra Kırmusaoğlu"}]},{id:"62553",title:"Antibiotic Use in Poultry Production and Its Effects on Bacterial Resistance",slug:"antibiotic-use-in-poultry-production-and-its-effects-on-bacterial-resistance",totalDownloads:7327,totalCrossrefCites:43,totalDimensionsCites:92,abstract:"A surge in the development and spread of antibiotic resistance has become a major cause for concern. Over the past few decades, no major new types of antibiotics have been produced and almost all known antibiotics are increasingly losing their activity against pathogenic microorganisms. The levels of multi-drug resistant bacteria have also increased. It is known that worldwide, more than 60% of all antibiotics that are produced find their use in animal production for both therapeutic and non-therapeutic purposes. The use of antimicrobial agents in animal husbandry has been linked to the development and spread of resistant bacteria. Poultry products are among the highest consumed products worldwide but a lot of essential antibiotics are employed during poultry production in several countries; threatening the safety of such products (through antimicrobial residues) and the increased possibility of development and spread of microbial resistance in poultry settings. This chapter documents some of the studies on antibiotic usage in poultry farming; with specific focus on some selected bacterial species, their economic importance to poultry farming and reports of resistances of isolated species from poultry settings (farms and poultry products) to essential antibiotics.",book:{id:"6978",slug:"antimicrobial-resistance-a-global-threat",title:"Antimicrobial Resistance",fullTitle:"Antimicrobial Resistance - A Global Threat"},signatures:"Christian Agyare, Vivian Etsiapa Boamah, Crystal Ngofi Zumbi and\nFrank Boateng Osei",authors:[{id:"182058",title:"Dr.",name:"Christian",middleName:null,surname:"Agyare",slug:"christian-agyare",fullName:"Christian Agyare"},{id:"261271",title:"MSc.",name:"Crystal Ngofi",middleName:null,surname:"Zumbi",slug:"crystal-ngofi-zumbi",fullName:"Crystal Ngofi Zumbi"},{id:"261272",title:"MSc.",name:"Frank Boateng",middleName:null,surname:"Osei",slug:"frank-boateng-osei",fullName:"Frank Boateng Osei"},{id:"261273",title:"Dr.",name:"Vivian Etsiapa",middleName:null,surname:"Boamah",slug:"vivian-etsiapa-boamah",fullName:"Vivian Etsiapa Boamah"}]},{id:"65914",title:"Introductory Chapter: The Action Mechanisms of Antibiotics and Antibiotic Resistance",slug:"introductory-chapter-the-action-mechanisms-of-antibiotics-and-antibiotic-resistance",totalDownloads:4428,totalCrossrefCites:6,totalDimensionsCites:10,abstract:null,book:{id:"8427",slug:"antimicrobials-antibiotic-resistance-antibiofilm-strategies-and-activity-methods",title:"Antimicrobials, Antibiotic Resistance, Antibiofilm Strategies and Activity Methods",fullTitle:"Antimicrobials, Antibiotic Resistance, Antibiofilm Strategies and Activity Methods"},signatures:"Sahra Kırmusaoğlu, Nesrin Gareayaghi and Bekir S. Kocazeybek",authors:[{id:"179460",title:"Associate Prof.",name:"Sahra",middleName:null,surname:"Kırmusaoğlu",slug:"sahra-kirmusaoglu",fullName:"Sahra Kırmusaoğlu"},{id:"248288",title:"Prof.",name:"Bekir",middleName:null,surname:"Kocazeybek",slug:"bekir-kocazeybek",fullName:"Bekir Kocazeybek"},{id:"406463",title:"Dr.",name:"Nesrin",middleName:null,surname:"Gareayaghi",slug:"nesrin-gareayaghi",fullName:"Nesrin Gareayaghi"}]},{id:"63397",title:"Antibiotic Resistance in Lactic Acid Bacteria",slug:"antibiotic-resistance-in-lactic-acid-bacteria",totalDownloads:2486,totalCrossrefCites:12,totalDimensionsCites:21,abstract:"Most starter cultures belong to the lactic acid bacteria group (LAB) and recognized as safe by the US Food and Drug Administration (FDA) and the European Food Safety Authority (EFSA). However, LAB may act as intrinsic or extrinsic reservoirs for antibiotic resistance (AR) genes. This fact may not constitute a safety concern itself, as the resistance gene transfer is vertical. Nevertheless, external genetic elements may induce changes that favor the horizontal transfer transmission of resistance from pathogens as well as from the human intestinal microbiota, which represents a severe safety issue. Some genus of AR LAB includes Enterococcus, Lactobacillus, Lactococcus, Leuconostoc, Pediococcus, and Streptococcus isolated from fermented meat and milk products. Currently, the WHO recommends that LAB used in the food industry should be free of resistance. Therefore, the objective of this chapter is to present an overview of the LAB antibiotic resistance and some methods to determine the same.",book:{id:"6978",slug:"antimicrobial-resistance-a-global-threat",title:"Antimicrobial Resistance",fullTitle:"Antimicrobial Resistance - A Global Threat"},signatures:"Yenizey M. Álvarez-Cisneros and Edith Ponce-Alquicira",authors:[{id:"256345",title:"Dr.",name:"Yenizey Merit",middleName:null,surname:"Alvarez Cisneros",slug:"yenizey-merit-alvarez-cisneros",fullName:"Yenizey Merit Alvarez Cisneros"},{id:"256347",title:"Dr.",name:"Edith",middleName:null,surname:"Ponce-Alquicira",slug:"edith-ponce-alquicira",fullName:"Edith Ponce-Alquicira"}]},{id:"49246",title:"Chitosan as a Biomaterial — Structure, Properties, and Electrospun Nanofibers",slug:"chitosan-as-a-biomaterial-structure-properties-and-electrospun-nanofibers",totalDownloads:4726,totalCrossrefCites:27,totalDimensionsCites:63,abstract:"Chitosan is a polysaccharide derived from chitin; chitin is the second most abundant polysaccharide in the world, after cellulose. Chitosan is biocompatible, biodegradable and non-toxic, so that it can be usedin medicalapplications such as antimicrobial and wound healing biomaterials. It also used as chelating agent due to its ability to bind with cholesterol, fats, proteins and metal ions.",book:{id:"4648",slug:"concepts-compounds-and-the-alternatives-of-antibacterials",title:"Concepts, Compounds and the Alternatives of Antibacterials",fullTitle:"Concepts, Compounds and the Alternatives of Antibacterials"},signatures:"H. M. Ibrahim and E.M.R. El- Zairy",authors:[{id:"90645",title:"Dr.",name:"Hassan",middleName:null,surname:"Ibrahim",slug:"hassan-ibrahim",fullName:"Hassan Ibrahim"},{id:"175694",title:"Dr.",name:"Enas",middleName:null,surname:"El- Zairy",slug:"enas-el-zairy",fullName:"Enas El- Zairy"}]}],onlineFirstChaptersFilter:{topicId:"897",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"81704",title:"Quorum Sensing Inhibition Based Drugs to Conquer Antimicrobial Resistance",slug:"quorum-sensing-inhibition-based-drugs-to-conquer-antimicrobial-resistance",totalDownloads:22,totalDimensionsCites:0,doi:"10.5772/intechopen.104125",abstract:"Quorum sensing is the cell to cell communication mechanism in microorganism through signalling molecules. Regulation of virulence factor, sporulation, proteolytic enzymes production, biofilm formation, auto-inducers, cell population density are key physiological process mediated through quorum-sensing (QS) signalling. Elevation of innate immune system and antibiotic tolerance of pathogens is highly increased with perspective of quorum-sensing (QS) activity. Development of novel drugs is highly attractive scenario against cell-cell communication of microbes. Design of synthetic drugs and natural compounds against QS signal molecules is vital combat system to attenuate microbial pathogenicity. Quorum sensing inhibitors (QSIs), quorum quenchers (QQs), efflux pump inhibitors (EPIs) act against multi-drug resistance strains (MDR) and other pathogenic microbes through regulation of auto-inducers and signal molecule with perceptive to growth arrest both in-vitro and in-vivo. QQs, QSIs and EPIs compounds has been validated with various animal models for high selection pressure on therapeutics arsenal against microbe’s growth inhibition. Promising QSI are phytochemicals and secondary metabolites includes polyacetylenes, alkaloids, polyphenols, terpenoids, quinones.",book:{id:"11373",title:"The Global Antimicrobial Resistance Epidemic - Innovative Approaches and Cutting-Edge Solutions",coverURL:"https://cdn.intechopen.com/books/images_new/11373.jpg"},signatures:"Kothandapani Sundar, Ramachandira Prabu and Gopal Jayalakshmi"},{id:"82372",title:"Unlocking the Potential of Ghost Probiotics in Combating Antimicrobial Resistance",slug:"unlocking-the-potential-of-ghost-probiotics-in-combating-antimicrobial-resistance",totalDownloads:20,totalDimensionsCites:0,doi:"10.5772/intechopen.104126",abstract:"Antimicrobial resistance is a global concern that requires immediate attention. Major causes of development of antimicrobial resistance in microbial cells are overuse of antimicrobials along the food chain especially in livestock, in preventing infections as well as misuse of antimicrobials by patients. Probiotics could be a viable alternative to antibiotics in the fight against antimicrobial resistance. Probiotic strains can act as a complement to antimicrobial therapy, improving antimicrobial function and enhancing immunity. However, there are safety concerns regarding the extensive use of live microbial cells especially in immunocompromised individuals; these include microbial translocation, inhibition of other beneficial microorganisms and development of antimicrobial resistance, among other concerns. Inevitably, ghost probiotics have become the favored alternative as they eliminate the safety and shelf-life problems associated with use of probiotics. Ghost probiotics are non-viable microbial cells (intact or broken) or metabolic products from microorganisms, which when administered in adequate amounts have biologic activity in the host and confer health benefits. Ghost probiotics exert biological effects similar to probiotics. However, the major drawback of using ghost probiotics is that the mechanism of action of these is currently unknown, hence more research is required and regulatory instruments are needed to assure the safety of consumers.",book:{id:"11373",title:"The Global Antimicrobial Resistance Epidemic - Innovative Approaches and Cutting-Edge Solutions",coverURL:"https://cdn.intechopen.com/books/images_new/11373.jpg"},signatures:"Abigarl Ndudzo, Sakhile Ndlovu, Nesisa Nyathi and Angela Sibanda Makuvise"},{id:"82178",title:"Managing Antimicrobial Resistance beyond the Hospital Antimicrobial Stewardship: The Role of One Health",slug:"managing-antimicrobial-resistance-beyond-the-hospital-antimicrobial-stewardship-the-role-of-one-heal",totalDownloads:16,totalDimensionsCites:0,doi:"10.5772/intechopen.104170",abstract:"Infections caused by micro-organisms affect the health of people and animals, causing morbidity and mortality, with Asia and Africa as the epicenters. Some of the infectious diseases are emerging and re-emerging in nature. Examples include viral hepatitis, Lassa fever, Ebola, yellow fever, tuberculosis, covid-19, measles, and malaria, among others. Antimicrobials have been playing an important role in the treatment of infections by these microbes. However, there has been a development of resistance to these antimicrobials as a result of many drivers. This write-up used secondary data to explore the management of antimicrobial resistance (AMR) beyond the hospital antimicrobial resistance steward using the one health concept. The findings showed AMR to be a transboundary, multifaceted ecosystem problem affecting both the developed and developing countries. It is also one of the top ten global public health threats facing mankind. Globally, AMR will cost over US$100 trillion in output loss by 2050, about 700,000 deaths a year, and 4,150,000 deaths in Africa by 2050. About 2.4 million people could die in high-income countries between 2015 and 2050 without a sustained effort to contain AMR. The drivers of AMR are beyond the hospital and hospital AMR stewardship. Therefore, the need for one health concept to manage it.",book:{id:"11373",title:"The Global Antimicrobial Resistance Epidemic - Innovative Approaches and Cutting-Edge Solutions",coverURL:"https://cdn.intechopen.com/books/images_new/11373.jpg"},signatures:"Istifanus Anekoson Joshua, Mathew Bobai and Clement Sokfa Woje"},{id:"81918",title:"Machine Learning for Antimicrobial Resistance Research and Drug Development",slug:"machine-learning-for-antimicrobial-resistance-research-and-drug-development",totalDownloads:52,totalDimensionsCites:0,doi:"10.5772/intechopen.104841",abstract:"Machine learning is a subfield of artificial intelligence which combines sophisticated algorithms and data to develop predictive models with minimal human interference. This chapter focuses on research that trains machine learning models to study antimicrobial resistance and to discover antimicrobial drugs. An emphasis is placed on applying machine learning models to detect drug resistance among bacterial and fungal pathogens. The role of machine learning in antibacterial and antifungal drug discovery and design is explored. Finally, the challenges and prospects of applying machine learning to advance basic research on and treatment of antimicrobial resistance are discussed. Overall, machine learning promises to advance antimicrobial resistance research and to facilitate the development of antibacterial and antifungal drugs.",book:{id:"11373",title:"The Global Antimicrobial Resistance Epidemic - Innovative Approaches and Cutting-Edge Solutions",coverURL:"https://cdn.intechopen.com/books/images_new/11373.jpg"},signatures:"Shamanth A. Shankarnarayan, Joshua D. Guthrie and Daniel A. Charlebois"},{id:"81891",title:"Alternatives to Antibiotics in Semen Extenders Used in Artificial Insemination",slug:"alternatives-to-antibiotics-in-semen-extenders-used-in-artificial-insemination",totalDownloads:27,totalDimensionsCites:0,doi:"10.5772/intechopen.104226",abstract:"Antimicrobial resistance is a serious global threat requiring a widespread response. Both veterinarians and medical doctors should restrict antibiotic usage to therapeutic use only, after determining the sensitivity of the causal organism. However, the addition of antibiotics to semen extenders for animal artificial insemination represents a hidden, non-therapeutic use of antimicrobial substances. Artificial insemination for livestock breeding is a huge global enterprise with hundreds of million sperm doses prepared annually. However, reporting of antimicrobial resistance in semen is increasing. This review discusses the consequences of bacteria in semen samples, as well as the effect of antimicrobial substances in semen extenders on bacteria in the environment and even on personnel. Alternatives to antibiotics have been reported in the scientific literature and are reviewed here. The most promising of these, removal of the majority of bacteria by colloid centrifugation, is considered in detail, especially results from an artificial insemination study in pigs. In conclusion, colloid centrifugation is a practical method of physically removing bacteria from semen, which does not induce antibiotic resistance. Sperm quality in stored semen samples may be improved at the same time.",book:{id:"11373",title:"The Global Antimicrobial Resistance Epidemic - Innovative Approaches and Cutting-Edge Solutions",coverURL:"https://cdn.intechopen.com/books/images_new/11373.jpg"},signatures:"Jane M. Morrell, Pongpreecha Malaluang, Aleksandar Cojkic and Ingrid Hansson"},{id:"81699",title:"Efflux Pumps among Urinary E. coli and K. pneumoniae Local Isolates in Hilla City, Iraq",slug:"efflux-pumps-among-urinary-e-coli-and-k-pneumoniae-local-isolates-in-hilla-city-iraq",totalDownloads:10,totalDimensionsCites:0,doi:"10.5772/intechopen.104408",abstract:"Urinary tract infections (UTI) are the most common bacterial infections affecting humans. Escherichia coli and Klebsiella pneumoniae were common enterobacteria engaged with community-acquired UTIs. Efflux pumps were vital resistance mechanisms for antibiotics, especially among enterobacteria. Overexpression of an efflux system, which results in a decrease in antibiotic accumulation, is an effective mechanism for drug resistance. The ATP-binding cassette (ABC) transporters, small multidrug resistance (SMR), and multidrug and toxic compound extrusion (MATE) families, the major facilitator superfamily (MFS), and the resistance-nodulation- cell division (RND) family are the five superfamilies of efflux systems linked to drug resistance. This chapter highlights the results of studying the prevalence of efflux pump genes among local isolates of E. coli and K. pneumoniae in Hilla City, Iraq. class RND AcrAB-TolC, AcrAD-TolC, and AcrFE-TolC genes detected by conventional PCR of E. coli and K. pneumoniae respectively. The result revealed approximately all studied efflux transporter were found in both E. coli and K. pneumoniae in different percentages. Biofilm formation were observed in 50(100%) of K. pneumoniae and 49(98%) of E. coli isolates were biofilm former and follow: 30(60%), 20(40%) were weak, 12(24%), 22(44%) were moderate and 7(14%) and 8(16%) were Strong biofilm former for E. coli and K. pneumoniae, respectively.",book:{id:"11373",title:"The Global Antimicrobial Resistance Epidemic - Innovative Approaches and Cutting-Edge Solutions",coverURL:"https://cdn.intechopen.com/books/images_new/11373.jpg"},signatures:"Hussein Al-Dahmoshi, Sahar A. Ali and Noor Al-Khafaji"}],onlineFirstChaptersTotal:13},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:330,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:9,numberOfPublishedChapters:139,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:123,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:21,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:11,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. This Biochemistry Series will address the current research on biomolecules and the emerging trends with great promise.",coverUrl:"https://cdn.intechopen.com/series/covers/11.jpg",latestPublicationDate:"August 2nd, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:33,editor:{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",slug:"miroslav-blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:4,paginationItems:[{id:"3",title:"Bacterial Infectious Diseases",coverUrl:"https://cdn.intechopen.com/series_topics/covers/3.jpg",isOpenForSubmission:!0,editor:{id:"205604",title:"Dr.",name:"Tomas",middleName:null,surname:"Jarzembowski",slug:"tomas-jarzembowski",fullName:"Tomas Jarzembowski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKriQAG/Profile_Picture_2022-06-16T11:01:31.jpg",biography:"Tomasz Jarzembowski was born in 1968 in Gdansk, Poland. He obtained his Ph.D. degree in 2000 from the Medical University of Gdańsk (UG). After specialization in clinical microbiology in 2003, he started studying biofilm formation and antibiotic resistance at the single-cell level. In 2015, he obtained his D.Sc. degree. His later study in cooperation with experts in nephrology and immunology resulted in the designation of the new diagnostic method of UTI, patented in 2017. He is currently working at the Department of Microbiology, Medical University of Gdańsk (GUMed), Poland. Since many years, he is a member of steering committee of Gdańsk branch of Polish Society of Microbiologists, a member of ESCMID. He is also a reviewer and a member of editorial boards of a number of international journals.",institutionString:"Medical University of Gdańsk, Poland",institution:null},editorTwo:{id:"484980",title:"Dr.",name:"Katarzyna",middleName:null,surname:"Garbacz",slug:"katarzyna-garbacz",fullName:"Katarzyna Garbacz",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003St8TAQAZ/Profile_Picture_2022-07-07T09:45:16.jpg",biography:"Katarzyna Maria Garbacz, MD, is an Associate Professor at the Medical University of Gdańsk, Poland and she is head of the Department of Oral Microbiology of the Medical University of Gdańsk. She has published more than 50 scientific publications in peer-reviewed journals. She has been a project leader funded by the National Science Centre of Poland. Prof. Garbacz is a microbiologist working on applied and fundamental questions in microbial epidemiology and pathogenesis. Her research interest is in antibiotic resistance, host-pathogen interaction, and therapeutics development for staphylococcal pathogens, mainly Staphylococcus aureus, which causes hospital-acquired infections. Currently, her research is mostly focused on the study of oral pathogens, particularly Staphylococcus spp.",institutionString:"Medical University of Gdańsk, Poland",institution:null},editorThree:null},{id:"4",title:"Fungal Infectious Diseases",coverUrl:"https://cdn.intechopen.com/series_topics/covers/4.jpg",isOpenForSubmission:!0,editor:{id:"174134",title:"Dr.",name:"Yuping",middleName:null,surname:"Ran",slug:"yuping-ran",fullName:"Yuping Ran",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bS9d6QAC/Profile_Picture_1630330675373",biography:"Dr. Yuping Ran, Professor, Department of Dermatology, West China Hospital, Sichuan University, Chengdu, China. Completed the Course Medical Mycology, the Centraalbureau voor Schimmelcultures (CBS), Fungal Biodiversity Centre, Netherlands (2006). International Union of Microbiological Societies (IUMS) Fellow, and International Emerging Infectious Diseases (IEID) Fellow, Centers for Diseases Control and Prevention (CDC), Atlanta, USA. Diploma of Dermatological Scientist, Japanese Society for Investigative Dermatology. Ph.D. of Juntendo University, Japan. Bachelor’s and Master’s degree, Medicine, West China University of Medical Sciences. Chair of Sichuan Medical Association Dermatology Committee. General Secretary of The 19th Annual Meeting of Chinese Society of Dermatology and the Asia Pacific Society for Medical Mycology (2013). In charge of the Annual Medical Mycology Course over 20-years authorized by National Continue Medical Education Committee of China. Member of the board of directors of the Asia-Pacific Society for Medical Mycology (APSMM). Associate editor of Mycopathologia. 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Kasenga",hash:"91cde4582ead884cb0f355a19b67cd56",volumeInSeries:4,fullTitle:"Malaria",editors:[{id:"86725",title:"Dr.",name:"Fyson",middleName:"Hanania",surname:"Kasenga",slug:"fyson-kasenga",fullName:"Fyson Kasenga",profilePictureURL:"https://mts.intechopen.com/storage/users/86725/images/system/86725.jpg",institutionString:"Malawi Adventist University",institution:{name:"Malawi Adventist University",institutionURL:null,country:{name:"Malawi"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7123",title:"Current Topics in Neglected Tropical Diseases",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7123.jpg",slug:"current-topics-in-neglected-tropical-diseases",publishedDate:"December 4th 2019",editedByType:"Edited by",bookSignature:"Alfonso J. Rodriguez-Morales",hash:"61c627da05b2ace83056d11357bdf361",volumeInSeries:3,fullTitle:"Current Topics in Neglected Tropical Diseases",editors:[{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7064",title:"Current Perspectives in Human Papillomavirus",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7064.jpg",slug:"current-perspectives-in-human-papillomavirus",publishedDate:"May 2nd 2019",editedByType:"Edited by",bookSignature:"Shailendra K. Saxena",hash:"d92a4085627bab25ddc7942fbf44cf05",volumeInSeries:2,fullTitle:"Current Perspectives in Human Papillomavirus",editors:[{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Bacterial Infectious Diseases",value:3,count:2},{group:"subseries",caption:"Parasitic Infectious Diseases",value:5,count:4},{group:"subseries",caption:"Viral Infectious Diseases",value:6,count:7}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:2},{group:"publicationYear",caption:"2021",value:2021,count:4},{group:"publicationYear",caption:"2020",value:2020,count:3},{group:"publicationYear",caption:"2019",value:2019,count:3},{group:"publicationYear",caption:"2018",value:2018,count:1}],authors:{paginationCount:303,paginationItems:[{id:"280338",title:"Dr.",name:"Yutaka",middleName:null,surname:"Tsutsumi",slug:"yutaka-tsutsumi",fullName:"Yutaka Tsutsumi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/280338/images/7961_n.jpg",biography:null,institutionString:null,institution:{name:"Fujita Health University",country:{name:"Japan"}}},{id:"116250",title:"Dr.",name:"Nima",middleName:null,surname:"Rezaei",slug:"nima-rezaei",fullName:"Nima Rezaei",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/116250/images/system/116250.jpg",biography:"Professor Nima Rezaei obtained an MD from Tehran University of Medical Sciences, Iran. He also obtained an MSc in Molecular and Genetic Medicine, and a Ph.D. in Clinical Immunology and Human Genetics from the University of Sheffield, UK. He also completed a short-term fellowship in Pediatric Clinical Immunology and Bone Marrow Transplantation at Newcastle General Hospital, England. Dr. Rezaei is a Full Professor of Immunology and Vice Dean of International Affairs and Research, at the School of Medicine, Tehran University of Medical Sciences, and the co-founder and head of the Research Center for Immunodeficiencies. He is also the founding president of the Universal Scientific Education and Research Network (USERN). Dr. Rezaei has directed more than 100 research projects and has designed and participated in several international collaborative projects. He is an editor, editorial assistant, or editorial board member of more than forty international journals. He has edited more than 50 international books, presented more than 500 lectures/posters in congresses/meetings, and published more than 1,100 scientific papers in international journals.",institutionString:"Tehran University of Medical Sciences",institution:{name:"Tehran University of Medical Sciences",country:{name:"Iran"}}},{id:"180733",title:"Dr.",name:"Jean",middleName:null,surname:"Engohang-Ndong",slug:"jean-engohang-ndong",fullName:"Jean Engohang-Ndong",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180733/images/system/180733.png",biography:"Dr. Jean Engohang-Ndong was born and raised in Gabon. After obtaining his Associate Degree of Science at the University of Science and Technology of Masuku, Gabon, he continued his education in France where he obtained his BS, MS, and Ph.D. in Medical Microbiology. He worked as a post-doctoral fellow at the Public Health Research Institute (PHRI), Newark, NJ for four years before accepting a three-year faculty position at Brigham Young University-Hawaii. Dr. Engohang-Ndong is a tenured faculty member with the academic rank of Full Professor at Kent State University, Ohio, where he teaches a wide range of biological science courses and pursues his research in medical and environmental microbiology. Recently, he expanded his research interest to epidemiology and biostatistics of chronic diseases in Gabon.",institutionString:"Kent State University",institution:{name:"Kent State University",country:{name:"United States of America"}}},{id:"188773",title:"Prof.",name:"Emmanuel",middleName:null,surname:"Drouet",slug:"emmanuel-drouet",fullName:"Emmanuel Drouet",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/188773/images/system/188773.png",biography:"Emmanuel Drouet, PharmD, is a Professor of Virology at the Faculty of Pharmacy, the University Grenoble-Alpes, France. As a head scientist at the Institute of Structural Biology in Grenoble, Dr. Drouet’s research investigates persisting viruses in humans (RNA and DNA viruses) and the balance with our host immune system. He focuses on these viruses’ effects on humans (both their impact on pathology and their symbiotic relationships in humans). He has an excellent track record in the herpesvirus field, and his group is engaged in clinical research in the field of Epstein-Barr virus diseases. He is the editor of the online Encyclopedia of Environment and he coordinates the Universal Health Coverage education program for the BioHealth Computing Schools of the European Institute of Science.",institutionString:null,institution:{name:"Grenoble Alpes University",country:{name:"France"}}},{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",biography:"Dr. Rodriguez-Morales is an expert in tropical and emerging diseases, particularly zoonotic and vector-borne diseases (especially arboviral diseases). He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},{id:"332819",title:"Dr.",name:"Chukwudi Michael",middleName:"Michael",surname:"Egbuche",slug:"chukwudi-michael-egbuche",fullName:"Chukwudi Michael Egbuche",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/332819/images/14624_n.jpg",biography:"I an Dr. Chukwudi Michael Egbuche. I am a Senior Lecturer in the Department of Parasitology and Entomology, Nnamdi Azikiwe University, Awka.",institutionString:null,institution:{name:"Nnamdi Azikiwe University",country:{name:"Nigeria"}}},{id:"284232",title:"Mr.",name:"Nikunj",middleName:"U",surname:"Tandel",slug:"nikunj-tandel",fullName:"Nikunj Tandel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/284232/images/8275_n.jpg",biography:'Mr. Nikunj Tandel has completed his Master\'s degree in Biotechnology from VIT University, India in the year of 2012. He is having 8 years of research experience especially in the field of malaria epidemiology, immunology, and nanoparticle-based drug delivery system against the infectious diseases, autoimmune disorders and cancer. He has worked for the NIH funded-International Center of Excellence in Malaria Research project "Center for the study of complex malaria in India (CSCMi)" in collaboration with New York University. The preliminary objectives of the study are to understand and develop the evidence-based tools and interventions for the control and prevention of malaria in different sites of the INDIA. Alongside, with the help of next-generation genomics study, the team has studied the antimalarial drug resistance in India. Further, he has extended his research in the development of Humanized mice for the study of liver-stage malaria and identification of molecular marker(s) for the Artemisinin resistance. At present, his research focuses on understanding the role of B cells in the activation of CD8+ T cells in malaria. Received the CSIR-SRF (Senior Research Fellow) award-2018, FIMSA (Federation of Immunological Societies of Asia-Oceania) Travel Bursary award to attend the IUIS-IIS-FIMSA Immunology course-2019',institutionString:"Nirma University",institution:{name:"Nirma University",country:{name:"India"}}},{id:"334383",title:"Ph.D.",name:"Simone",middleName:"Ulrich",surname:"Ulrich Picoli",slug:"simone-ulrich-picoli",fullName:"Simone Ulrich Picoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334383/images/15919_n.jpg",biography:"Graduated in Pharmacy from Universidade Luterana do Brasil (1999), Master in Agricultural and Environmental Microbiology from Federal University of Rio Grande do Sul (2002), Specialization in Clinical Microbiology from Universidade de São Paulo, USP (2007) and PhD in Sciences in Gastroenterology and Hepatology (2012). She is currently an Adjunct Professor at Feevale University in Medicine and Biomedicine courses and a permanent professor of the Academic Master\\'s Degree in Virology. She has experience in the field of Microbiology, with an emphasis on Bacteriology, working mainly on the following topics: bacteriophages, bacterial resistance, clinical microbiology and food microbiology.",institutionString:null,institution:{name:"Universidade Feevale",country:{name:"Brazil"}}},{id:"229220",title:"Dr.",name:"Amjad",middleName:"Islam",surname:"Aqib",slug:"amjad-aqib",fullName:"Amjad Aqib",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229220/images/system/229220.png",biography:"Dr. Amjad Islam Aqib obtained a DVM and MSc (Hons) from University of Agriculture Faisalabad (UAF), Pakistan, and a PhD from the University of Veterinary and Animal Sciences Lahore, Pakistan. Dr. Aqib joined the Department of Clinical Medicine and Surgery at UAF for one year as an assistant professor where he developed a research laboratory designated for pathogenic bacteria. Since 2018, he has been Assistant Professor/Officer in-charge, Department of Medicine, Manager Research Operations and Development-ORIC, and President One Health Club at Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan. He has nearly 100 publications to his credit. His research interests include epidemiological patterns and molecular analysis of antimicrobial resistance and modulation and vaccine development against animal pathogens of public health concern.",institutionString:"Cholistan University of Veterinary and Animal Sciences",institution:{name:"University of Agriculture Faisalabad",country:{name:"Pakistan"}}},{id:"333753",title:"Dr.",name:"Rais",middleName:null,surname:"Ahmed",slug:"rais-ahmed",fullName:"Rais Ahmed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/333753/images/20168_n.jpg",biography:null,institutionString:null,institution:{name:"University of Agriculture Faisalabad",country:{name:"Pakistan"}}},{id:"62900",title:"Prof.",name:"Fethi",middleName:null,surname:"Derbel",slug:"fethi-derbel",fullName:"Fethi Derbel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/62900/images/system/62900.jpeg",biography:"Professor Fethi Derbel was born in 1960 in Tunisia. He received his medical degree from the Sousse Faculty of Medicine at Sousse, University of Sousse, Tunisia. He completed his surgical residency in General Surgery at the University Hospital Farhat Hached of Sousse and was a member of the Unit of Liver Transplantation in the University of Rennes, France. He then worked in the Department of Surgery at the Sahloul University Hospital in Sousse. Professor Derbel is presently working at the Clinique les Oliviers, Sousse, Tunisia. His hospital activities are mostly concerned with laparoscopic, colorectal, pancreatic, hepatobiliary, and gastric surgery. He is also very interested in hernia surgery and performs ventral hernia repairs and inguinal hernia repairs. He has been a member of the GREPA and Tunisian Hernia Society (THS). During his residency, he managed patients suffering from diabetic foot, and he was very interested in this pathology. For this reason, he decided to coordinate a book project dealing with the diabetic foot. Professor Derbel has published many articles in journals and collaborates intensively with IntechOpen Access Publisher as an editor.",institutionString:"Clinique les Oliviers",institution:null},{id:"300144",title:"Dr.",name:"Meriem",middleName:null,surname:"Braiki",slug:"meriem-braiki",fullName:"Meriem Braiki",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/300144/images/system/300144.jpg",biography:"Dr. Meriem Braiki is a specialist in pediatric surgeon from Tunisia. She was born in 1985. She received her medical degree from the University of Medicine at Sousse, Tunisia. She achieved her surgical residency training periods in Pediatric Surgery departments at University Hospitals in Monastir, Tunis and France.\r\nShe is currently working at the Pediatric surgery department, Sidi Bouzid Hospital, Tunisia. Her hospital activities are mostly concerned with laparoscopic, parietal, urological and digestive surgery. She has published several articles in diffrent journals.",institutionString:"Sidi Bouzid Regional Hospital",institution:null},{id:"229481",title:"Dr.",name:"Erika M.",middleName:"Martins",surname:"de Carvalho",slug:"erika-m.-de-carvalho",fullName:"Erika M. de Carvalho",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229481/images/6397_n.jpg",biography:null,institutionString:null,institution:{name:"Oswaldo Cruz Foundation",country:{name:"Brazil"}}},{id:"186537",title:"Prof.",name:"Tonay",middleName:null,surname:"Inceboz",slug:"tonay-inceboz",fullName:"Tonay Inceboz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/186537/images/system/186537.jfif",biography:"I was graduated from Ege University of Medical Faculty (Turkey) in 1988 and completed his Med. PhD degree in Medical Parasitology at the same university. I became an Associate Professor in 2008 and Professor in 2014. I am currently working as a Professor at the Department of Medical Parasitology at Dokuz Eylul University, Izmir, Turkey.\n\nI have given many lectures, presentations in different academic meetings. I have more than 60 articles in peer-reviewed journals, 18 book chapters, 1 book editorship.\n\nMy research interests are Echinococcus granulosus, Echinococcus multilocularis (diagnosis, life cycle, in vitro and in vivo cultivation), and Trichomonas vaginalis (diagnosis, PCR, and in vitro cultivation).",institutionString:"Dokuz Eylül University",institution:{name:"Dokuz Eylül University",country:{name:"Turkey"}}},{id:"71812",title:"Prof.",name:"Hanem Fathy",middleName:"Fathy",surname:"Khater",slug:"hanem-fathy-khater",fullName:"Hanem Fathy Khater",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/71812/images/1167_n.jpg",biography:"Prof. Khater is a Professor of Parasitology at Benha University, Egypt. She studied for her doctoral degree, at the Department of Entomology, College of Agriculture, Food and Natural Resources, University of Missouri, Columbia, USA. She has completed her Ph.D. degrees in Parasitology in Egypt, from where she got the award for “the best scientific Ph.D. dissertation”. She worked at the School of Biological Sciences, Bristol, England, the UK in controlling insects of medical and veterinary importance as a grant from Newton Mosharafa, the British Council. Her research is focused on searching of pesticides against mosquitoes, house flies, lice, green bottle fly, camel nasal botfly, soft and hard ticks, mites, and the diamondback moth as well as control of several parasites using safe and natural materials to avoid drug resistances and environmental contamination.",institutionString:null,institution:{name:"Banha University",country:{name:"Egypt"}}},{id:"99780",title:"Prof.",name:"Omolade",middleName:"Olayinka",surname:"Okwa",slug:"omolade-okwa",fullName:"Omolade Okwa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/99780/images/system/99780.jpg",biography:"Omolade Olayinka Okwa is presently a Professor of Parasitology at Lagos State University, Nigeria. She has a PhD in Parasitology (1997), an MSc in Cellular Parasitology (1992), and a BSc (Hons) Zoology (1990) all from the University of Ibadan, Nigeria. She teaches parasitology at the undergraduate and postgraduate levels. She was a recipient of a Commonwealth fellowship supported by British Council tenable at the Centre for Entomology and Parasitology (CAEP), Keele University, United Kingdom between 2004 and 2005. She was awarded an Honorary Visiting Research Fellow at the same university from 2005 to 2007. \nShe has been an external examiner to the Department of Veterinary Microbiology and Parasitology, University of Ibadan, MSc programme between 2010 and 2012. She is a member of the Nigerian Society of Experimental Biology (NISEB), Parasitology and Public Health Society of Nigeria (PPSN), Science Association of Nigeria (SAN), Zoological Society of Nigeria (ZSN), and is Vice Chairperson of the Organisation of Women in Science (OWSG), LASU chapter. She served as Head of Department of Zoology and Environmental Biology, Lagos State University from 2007 to 2010 and 2014 to 2016. She is a reviewer for several local and international journals such as Unilag Journal of Science, Libyan Journal of Medicine, Journal of Medicine and Medical Sciences, and Annual Research and Review in Science. \nShe has authored 45 scientific research publications in local and international journals, 8 scientific reviews, 4 books, and 3 book chapters, which includes the books “Malaria Parasites” and “Malaria” which are IntechOpen access publications.",institutionString:"Lagos State University",institution:{name:"Lagos State University",country:{name:"Nigeria"}}},{id:"273100",title:"Dr.",name:"Vijay",middleName:null,surname:"Gayam",slug:"vijay-gayam",fullName:"Vijay Gayam",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/273100/images/system/273100.jpeg",biography:"Dr. Vijay Bhaskar Reddy Gayam is currently practicing as an internist at Interfaith Medical Center in Brooklyn, New York, USA. He is also a Clinical Assistant Professor at the SUNY Downstate University Hospital and Adjunct Professor of Medicine at the American University of Antigua. He is a holder of an M.B.B.S. degree bestowed to him by Osmania Medical College and received his M.D. at Interfaith Medical Center. His career goals thus far have heavily focused on direct patient care, medical education, and clinical research. He currently serves in two leadership capacities; Assistant Program Director of Medicine at Interfaith Medical Center and as a Councilor for the American\r\nFederation for Medical Research. As a true academician and researcher, he has more than 50 papers indexed in international peer-reviewed journals. He has also presented numerous papers in multiple national and international scientific conferences. His areas of research interest include general internal medicine, gastroenterology and hepatology. He serves as an editor, editorial board member and reviewer for multiple international journals. His research on Hepatitis C has been very successful and has led to multiple research awards, including the 'Equity in Prevention and Treatment Award” from the New York Department of Health Viral Hepatitis Symposium (2018) and the 'Presidential Poster Award” awarded to him by the American College of Gastroenterology (2018). 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His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. 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