Binding energy and geometrical data for nanotube-adsorbate complexes C69H20Pt(XY) (Yeung et al. 2007; Yeung et al. 2010).
Carbon nanotubes (CNTs) have been the subject of intensive research since their discovery by Iijima in the early 1990s (Iijima 1991). Single-walled carbon nanotubes (SWCNTs, Iijima & Ichihashi 1993; Bethune et al. 1993) are of particular interest because the electronic properties of these nanomaterials can vary from semiconducting to metallic depending on its molecular structure. This contrasts multi-walled carbon nanotubes (MWCNTs), which are metallic and exhibit a zero bandgap. Fundamental understanding of these supramolecular carbon allotropes (Tasis et al. 2006; Ajayan 1999) is essential to the development of new nanomaterials for applications in biosystems, sensors (Wang & Yeow 2009; Hu & Hu 2009; Li et al. 2008), optics (Avouris 2008), nanomechanics (Li et al. 2008; Park 2004), nanoelectronics (Park 2004; Fuhrer 2003; Tsukagoshi 2002), and catalysis (Serp 2003, Tian et al. 2006, Yeung et al. 2011).
The molecular structure of SWCNTs can be described as a cylindrical roll of an infinite graphene sheet and is characterized by a chiral circumferential vector AB =
Each individual C atom in the sidewall of a CNT exhibits pyramidalization and partial
Carbon nanotubes are characterized by a very high aspect ratio (i.e., length per width) and display a very large surface area. Attractive interactions by van der Waals or weak long-range covalent bonding on the order of 0.50 to 0.95 eV per nanometer of tube-to-tube contact have been observed. Aggregation of CNTs often results in the generation of hexagonally packed bundles or ropes. SWCNTs exhibit extensive levels of electron delocalization and strong confinement effects that result in a pronounced one-dimensionality and weak interaction between electrons and phonons. These nanomaterials are ballistic conductors and exhibit two units of quantum conductance (i.e., 4
Natural carbon nanotubes can exhibit defects formed either during their synthesis or as a result of environmental stress that have significant effects on the geometric and electronic properties of carbon nanomaterials (Collins 2010; Charlier 2002). The most typical type of defects are point vacancies in which an atom is missing in the crystalline lattice of the nanotube backbone and occur as a result of external radiation (e.g., high energy electron, ion, or neutron radiation) in which a carbon atom is either dislodged or fully removed. A single vacancy of this type generates three dangling bonds (DBs) and immediately undergoes structural reorganization, for example, yielding the 5-1DB defect in which one five-membered carbocycle is formed, leaving a single C atom with a reactive DB (Berber & Oshiyama 2006; Ajayan 1998). Different from point vacancies, other structural defects arising from geometric rearrangements may also be present in nanotube sidewalls. The simplest of these rearrangements is the pentagon-heptagon defect in which a single C–C bond positioned between two adjacent hexagon rings undergoes a simple bond rotation, resulting in the formation of two non-hexagonal rings. Pentagon-heptagon defects have minimal effect on the local environment of the nanotube but induce a global buckling of the macromolecule, leading to significant changes in conductivity and aggregation (Chico 2010; Sonia & Niranjan 2010). Of note, two adjacent pentagon-heptagon defects can form a pentagonal-heptagonal-heptagonal-pentagonal (5775) structure known also as the Stone-Wales (SW) defect (Stone & Wales 1986).
Chemical functionalization provides scientists an opportunity for fine-tuning the electrical properties of carbon nanotubes for the desired application. CNTs are known to exhibit interstitial defects, or extra atoms not present in a lattice site, as a result of atmospheric oxidation (Collins 2010). Covalent modification by treatment of these carbon macromolecules with chemical reagents has been accomplished (Karousis et al. 2010; Tasis et al. 2006). The chemical reactivity of nanotube sidewalls bears some resemblance to that of olefins (i.e., C=C double bonds). As such, strategies including ozonolysis, Diels-Alder cycloaddition, osmylation, hydroboration, carbene addition, nitrene addition, dipolar cycloaddition of azomethine ylides, and vinylcarbonylation via zwitterionic intermediates are possible. Other methods include fluorination followed by nucleophilic substitution, dissolving metal reduction (i.e., Billups reaction), electrophilic oxidations, and free radical reactions including alkylation, perfluoroalkylation, and arylation.
Direct substitutional replacement of a sidewall C atom with a heteroatom is another alternative for electronic tuning (Ewels et al. 2010; Glerup et al. 2010). Substitutional doping of a SWCNT produces a hetero-SWCNT (HSWCNT) that exhibits geometric and electronic properties distinct from pristine carbon nanotubes depending on the doping concentration. Replacement of a single C atom with N or B is of particular interest because of the generation of quasibound states consisting of
Although physisorption of transition metals onto CNTs is a known process, substitutional doping in which the transition metal atom is embedded into the sidewall remains an unsolved challenge in nanoscience, although some researchers have proposed that this transformation may be assisted by the presence of vacancy defects (Yang et al. 2006; Zhuang et al. 2008). The corresponding transition metal substitutionally doped fullerenes, however, have been prepared experimentally and characterized (Branz et al. 1998; Poblet et al. 1999; Kong et al. 2003). For example,
Theoretical studies of transition metal-doped fullerenes suggest a decrease in the energy gap between the highest occupied molecular orbital (HOMO) and the lowest unoccupied molecular orbital (LUMO), leading to both higher conductivity and reactivity (Changgeng et al. 2001). As such, transition metal-doped SWCNTs may display enhanced electronic properties in comparison to their undoped analogs. The introduction of transition metals is an attractive prospect because of the inherently rich chemistry of transition metal surfaces and organometallic complexes. By adding
Our work in SWCNTs and their substitutionally doped analogs (i.e., HSWCNTs) is driven by a fundamental interest in the unique chemical reactivity afforded by these macromolecules. We have focused our investigations primarily on defected and substitutionally doped nanotubes because of their potential applications in biological systems, sensory technology, nanoelectronics, and catalysis. In this account, we highlight our theoretical studies on the geometric and electronic structure of defected and doped SWCNTs, their chemical reactivity, and proposed applications of these nanomaterials. We also describe the related defected and doped boron-nitride nanotubes (BNNTs) and their behavior.
2. Models and computational details
We chose the (5,5) armchair metallic SWCNT and (5,0) zigzag SWCNT as models for all computations with suitable capping groups (i.e., either a fullerene hemisphere or H atoms). All calculations were done with Gaussian 03 (Frisch et al. 2003). Natural bond orbital (NBO) analysis was conducted with Gaussian NBO Version 3.1 (Reed et al. 1988) to obtain the frontier molecular orbitals (FMOs, Fukui 1982): the HOMO and the LUMO. Density of states (DOS) and local DOS (LDOS) studies were performed using PyMOlyze Version 1.1 (Tenderholt 2005). The Hessian was calculated to verify the nature of stationary points on the potential energy surface (PES, either a local minimum or transition state). Optimizations using spin-restricted and spin-unrestricted methods provided the same results.
To study the substitutional doping of SWCNTs, we envisioned a chemical reaction between a single vacancy defect on the backbone of the nanotube and a suitable atom transfer reagent. To this end, we evaluated the use of NO and ozone (O3) for N- and O-substitutional doping, respectively. For N-doped SWCNT synthesis with NO (Liu et al. 2006), a single C atom was removed from the middle of a (5,5) segment capped with H atoms (C199H20), yielding a metastable conformation with three dangling bonds. Geometry optimization with semiempirical MNDO-PM3 method (Stewart 1989) and hybrid Hartree-Fock/density functional theory (DFT) method B3LYP (Becke 1988; Lee et al. 1988) using Pople’s 6-31G basis set (Ditchfield et al. 1971) afforded the 5-1DB defect. To study the chemical reactivity, we employed a two-layer ONIOM (our own N-layered integrated molecular orbital and molecular mechanics) model (Dapprich et al. 1999), with the nine-membered ring surrounding the defect modeled with C9H8 as the higher layer at B3LYP/6-31G(d), while all other atoms were the lower layer treated with universal force field (UFF, Rappe et al. 1992). For O-doped SWCNT synthesis with O3 (Liu et al. 2006b), an analogous system was used (C119H20). Geometry optimization was achieved with semiempirical AM1 (Dewar et al. 1985) and B3LYP/6-31G. Static quantum mechanical calculations were validated by the atom-centered density matrix propagation (ADMP) based
To study transition metal-doped SWCNTs, we initiated our studies using one-dimensional periodic boundary conditions with 100 carbon atoms in the primitive cell (Chen et al. 2011). Replacement of a single C atom in the middle of the cell with a transition metal was performed, followed by geometry optimization with PBEPBE (Perdew et al. 1996) using LANL2DZ (Dunning Jr. & Hay 1976), Hay and Wadt’s relativistic 18-electron Los Alamos National Laboratory effective core pseudopotential (ECP, Hay & Wadt 1985). We then focused our investigations on Pt due to its prevalence in well-defined organometallic complexes and heterogeneous catalysis. Two (5,5) models were chosen in which a C atom was substituted with Pt: 1) C69H20Pt with H caps (Yeung et al. 2007; Yeung et al. 2008), and 2) C170 with
To study the importance of the carbon backbone, the isoelectronic transition metal-doped single-walled boron nitride nanotube (BNNT) and its undoped analog were investigated (Chen et al. 2010). Defected BNNT models containing SW defects (Stone & Wales 1986) had formula B45N45H20, while Pt substitutional doping gave two isomers, B44N45H20Pt and B45N44H20Pt. DFT calculations were performed using B3LYP/LANL2MB, followed by LANL2DZ.
3. Defected SWCNTs
3.1. Defected SWCNT rods
We investigated vacancy defects of SWCNTs by removing a single atom from the middle of model (5,5) SWCNT rod capped with H atoms (C200H20), yielding a defected SWCNT (C199H20) that undergoes subsequent structural rearrangement to the 5-1DB defect (Figure 3, Liu et al. 2006). In our model system, a single C atom protrudes to the exterior of the sidewall and is the active carbon (C1). Other than the nine C atoms surrounding the vacancy, the remainder C atoms in the hexagonal lattice remain relatively unaffected. Because of coordinative unsaturation and less steric hindrance, a higher chemical reactivity is expected. The electronic structure was affected by introduction of the defect, as determined by a decrease in HOMO−LUMO gap from 1.38 to 0.84 eV. The HOMO of the defected SWCNT contains a large contribution from the lone pair on the active carbon atom and the
3.2. Substitutional N-doping of SWCNTs via reaction with NO
Based on FMO analysis, the active carbon (C1) of the 5-1DB defect, expected to be reactive toward small molecules, contains an
Nitrogen monoxide is of particular interest due to its biological relevance (Miller & Megson 2007). In fact, while NO has a reputation for destroying O3, causing cancer, and fostering acid rain, it is a critical signaling molecule in biological systems, important for learning and memory, blood pressure regulation, skin homeostasis, inflammation, and carcinoma metastasis. As such, NO was named “Molecule of the Year” in 1992 (Culotta & Koshland Jr. 1992). Physiological NO is biosynthesized via a five-electron oxidation of the amino acid arginine (Figure 5) and can impact biosystems based on its ability to interact with molecular oxygen to yield reactive oxygen species (ROS) including hydroxyl radicals (HO), nitrogen dioxide (N2O4), and peroxynitrite (ONOO–). Free NO exhibits polarization where the O atom bears a charge of −0.181, thus making chemical reactivity likely.
The reaction of NO with the defected SWCNT proceeds in two distinct stages. First, an electrostatic interaction between the defected SWCNT and NO takes place, involving an O-end attack of NO onto the active C atom via an orbital interaction between the singly-occupied molecular orbital (SOMO) of NO and the HOMO of the SWCNT (Figure 6), producing heterocycle INT1 containing an N−O bond. This rate-limiting step takes place rapidly with a low activation barrier (8.6 kcal/mol). Next, the N atom undergoes insertion into the nearby C2−C3 bond of the adjacent pentagon, expanding the pentagon via a three-membered transition state to liberate INT2 containing a six-membered N-containing heterocycle. C1−N bond formation then occurs with concomitant cleavage of the C1−O bond to give INT3, formally an N-doped SWCNT that has undergone pyrimidalizing oxygenation where the N atom has filled the single vacancy where the C atom was removed (i.e., substitutional doping). The N−O bond is relatively weak, with a bond length of 1.41 Å and a partial charge of −0.574 residing on the O atom. A second equivalent of NO initiates cleavage of this N−O bond via a four-membered concerted and asynchronous transition state, liberating one molecule of nitrogen dioxide (NO2) and Product, the N-doped SWCNT (C199H20N), a thermodynamically feasible process (ΔE = 78.3 kcal/mol).
In accord with literature data (Nevidomskyy et al. 2003), the geometry of N-doped HSWCNT model (C199H20N) strongly resembles the undoped, defect-free SWCNT (C200H20, Figure 7). Substitutional doping leads to a decreased HOMO−LUMO gap (0.74 eV) and slight polarization of the nanotube, with the N atom bearing a charge of −0.325.
3.3. Biological applications of defected SWCNTs and reactions with NO: Therapeutics and biosensing
Maintaining homeostasis of physiological NO is critical to biological systems (Miller & Megson 2007). As such, if future nanodevices are implanted into living organisms, it may interact with the biocycles of NO and strongly impact the amount of NO present. Given our studies (Liu et al. 2006), we envision the use of vacancy defective nanotubes in reducing the local concentration of NO by the irreversible chemical reaction depicted in Figure 6. For every single vacancy, two molecules of NO are consumed, producing a N-doped SWCNT and one molecule of NO2 as a byproduct. This process can be controlled in both location and defect concentration by inducing the selective formation of single vacancies by applying external stimuli to the area of interest. We can imagine, for example, the employment of ultraviolet light as a form of medical treatment. This strategy would provide a platform for physicians to carefully control the amount of NO present in any given biological system. Manipulating the local concentration of NO would be achieved by a hybrid approach involving chemically designed pharmaceutical agents such as glyceryl trinitrate and sodium nitroprusside (Figure 8), as well as new technologies involving materials such as zeolites (Wheatley et al. 2006) and Pt nanoparticles (Caruso et al. 2007). Recent work on the antithrombotic activity of NO drugs has confirmed that controlled release is essential to these types of treatments and we expect CNTs to play a critical role in the development of new therapeutic techniques in the future.
We can also imagine a scenario in which nanotubes are used as a preventative measure to control the amount of ROS present in the body; in other words, CNTs could act as an artificial antioxidant. Because it is known that the introduction of N atoms into nanotube sidewalls increases clearance rates (Singh et al. 2006), their removal from the biological system may be possible following irreversible NO capture. This suggests that the antioxidant properties of these carbon macromolecules may reverse the damage caused by high-energy processes, including harmful UV-A and UV-B rays from the sun. If defect-free, pristine SWCNTs can be implanted into the human body, environmental stresses may trigger the formation of defects, leading to a decrease in the amount of free biological NO.
Defected SWCNTs, if embedded in physiological systems, can serve as a sensor for biological NO. Unlike conventional methods, which involve breath analysis (Menzel et al. 2001), the use of these nanomaterials offers a direct evaluation of NO concentrations at any given location based on the known ability of environmental stresses to induce vacancy defect formation. Quantitative analysis may be achieved via isolation of excreted N-doped SWCNTs in comparison to pristine SWCNTs assuming equal clearance rates. Additionally, we expect that substitutional N-doping results in increased conductivity, since our studies have revealed a decreased HOMO−LUMO gap from 1.38 to 0.74 eV (Liu et al. 2006). If we can monitor electrical current passing through the nanotube, we would have an
As promising as they are, therapeutic applications of SWCNTs necessitate an understanding of nanotoxicology (Oberdorster et al. 2007; Buzea et al. 2007; Lam et al. 2006; Karakoti et al. 2006; Nel et al. 2006). Because macromolecules resist metabolism by macrophages, nanotubes are postulated to persist indefinitely in biological systems, a cause for concern due to bioaccumulation. These effects are further complicated by subtle differences between methods of preparation and the types of defects present that strongly affect intertube interactions and bundle formation. Functionalization is also critical. The introduction of carbonyl (C=O), carboxyl (COOH), and hydroxyl (OH) groups, for example, has resulted in increased cytotoxicity either after contact with cell membranes or following internalization. On the other hand, functionalization with ammonium cations has demonstrated enhanced clearance rates of these nanomaterials (Singh et al. 2006). Nanotoxicity is proposed to be a result of oxidative stress caused by the generation of ROS in which light-induced formation of electron-hole pairs and unpaired electrons triggers oxidation of molecular oxygen (O2) to superoxide (O2–), promoted by the presence of reactive groups and defects (Karakoti et al. 2006; Nel et al. 2006). Although nature counteracts the effect of ROS, such as by superoxide dismutase or glutathione, accumulation of these reactive species remains problematic. CNTs exhibit a known cytotoxicity in human skin fibroblasts, macrophages, and developing zebrafish embryos, and the particulate nature of these nanomaterials can cause interstitial fibrosis and pulmonary toxicity. Clinically relevant data, however, remains sparse, and recent research has suggested that nanotubes can persist without causing toxicity (Schipper et al. 2008) or any immunological or inflammation reactions (Chiaretti et al. 2008). It is clear that further work is necessary before any clear conclusions can be made regarding nanotoxicology and its impact on human health.
3.4. Substitutional O-doping of SWCNTs via reaction with O3
In analogy to NO, 5-1DB defects react exothermically with O3 (Liu et al. 2006a). In traditional organic chemistry, O3 is a strong oxidizing agent that is capable of cleaving C=C double bonds, generating two C=O bonds via the Criegee mechanism (Kuczkowski 1992). Because the sidewalls of CNTs exhibit π-frameworks of C atoms, it is reasonable to presume that ozonization can take place. We considered a C120H20 segment of the (5,5) armchair SWCNT and its defected analog C119H20 by removal of a single C atom in the middle of the nanotube. C1 was confirmed as the active C atom within the 5-1DB defect, analogous to our earlier work (Liu et al. 2006).
Only the nine C atoms surrounding the vacancy defect were evaluated in this SWCNT ozonization reaction. Although these C atoms exhibit partial C=C double bond character within the backbone of the defect, the pathway that is most energetically favored involves the direct interaction between ozone and C1 (Figure 9). The first step is physisorption of O3 onto the surface of the SWCNT, forming INT, resulting in a transfer of 0.19 electrons from the carbon backbone to O3. A concerted oxygenation and loss of singlet dioxygen liberates Product (C119H20O) via a four-membered transition state TS. This step is barrierless (−0.3 kcal/mol) and produces a substitutionally O-doped SWCNT with the release of 88.7 kcal/mol. Subsequent relaxation of singlet to triplet O2 results in further stabilization. We also performed ADMP-AIMD dynamics simulations to confirm our static analysis of the 5-1DB defect ozonization and found that at 300 K, a spontaneous reaction occurs between O3 and C1 in less than 50 fs. The structure of this O-doped SWCNT differs from our N-doped SWCNT derived from NO (
Because of the ease of oxygenation by ozonization of 5-1DB defects, it has been proposed that such single vacancies are often short-lived species that may rapidly travel through the backbone and annihilate each other (Collins 2010). It would be interesting to see whether other weaker oxygen sources including O2 and H2O may be able to oxidize a 5-1DB defect. By studying these processes, we would come to a better understanding of the fate of defect-free and defected SWCNTs within biological systems.
4. Substitutionally doped SWCNTs
4.1. Transition metal-doped SWCNT rods with hydrogen caps
Substitutional doping of SWCNTs with transition metals is yet to be experimentally realized. However, we became particularly interested in this material from theoretical perspective, particularly because of its tremendous potential in nanosensory technology and nanocatalysis based on the rich chemical reactivity of transition metals.
Our studies with N- and O-doped SWCNTs suggest that heteroatoms typically prefer to be situated to the exterior of the nanotube superstructure in which the dopant forms a tripodal structure with the three adjacent C atoms (Liu et al. 2006; Liu et al. 2006a). To confirm this assessment, we used a truncated (5,5) SWCNT capped with H atoms and substituted a single C atom in the middle of the segment with a transition metal considering both the possibility of external doping and internal doping (Chen et al. 2011). Our calculations are consistent with the proposal that
4.2. Pt-doped SWCNT rods with hydrogen caps
A smaller segment of the (5,5) SWCNT with H caps revealed results consistent with the structure and electronic properties of the larger model described above (Figure 11, Yeung et al. 2007). A brief comparison of the FMOs of both models confirms that the shorter C69H20Pt segment suitably describes sidewall doping with the transition metal without the need to use periodic boundary conditions. The dopant Pt atom prefers to adopt a structural arrangement in which it protrudes to the exterior of the sidewall of the SWCNT, due to the larger atomic radius of the Pt atom and subtle interactions between metal
4.3. Pt-doped SWCNT rods with fullerene caps
Next, we constructed a (5,5) SWCNT rod capped with fullerene hemispheres (C170, Figure 12a) and substituted a single C atom with a Pt atom at the cap-end (C169Pt(ce), Figure 12b), at the cap (C169Pt(c), Figure 12c), and along the sidewall (C169Pt(w), Figure 12d, Tian et al. 2006). These nanorods exhibit slightly decreased HOMO−LUMO gaps in comparison to the pristine all-carbon compound.
Pt substitution at the cap-end is the most stable type of doping, with cap-doping and wall-doping sitting 0.8 and 17.9 kcal/mol higher in energy. In our analysis, the triplet spin state was higher in energy than the singlet state. By calculating the FMOs of these model systems (Figure 13), we observed a strong interaction between the Pt 5
4.4. Pt-doped BNNT rods with hydrogen caps
Boron nitride nanotubes are isoelectronic with carbon nanotubes that exhibit different structural, electronic, and chemical features (Wang et al. 2010, Golberg et al. 2010). Indeed, the B−N couple is isoelectronic with the C−C bond but locally exhibits charge separation due to the difference in electronegativity. While B has an empty
Natural defects in boron nanotubes can be induced from mechanical fractures, with SW defects consisting of a 5775 structure being more stable than corresponding quadrilateral-octagonal-octagonal-quadrilateral (4884) structure (Karousis 2010). Using a truncated (5,5) BNNT model capped with H atoms (B45N45H20, Figure 14, Chen et al. 2010), we considered two SW defective structures resulting from a slant B−N bond rotation (SW1) or a vertical B−N bond rotation (SW2). In our defect-free BNNT model, the HOMO−LUMO gap is 6.02 eV, rendering this molecule a good insulator. By introducing SW defects, a decrease in the HOMO−LUMO gap was observed (4.98 and 5.19 eV for SW1 and SW2, respectively).
Vacancy defects in CNTs have been shown to undergo incorporation of transition metal atoms into their backbone (Yang et al. 2006; Zhuang et al. 2008). Substitutional doping of BNNTs is a logical extension, although replacement of either a single N or B atom yields two different materials (Figure 14). Although the mechanism of Pt doping is unclear, our studies confirm the existence of doublet ground states and a decreased band gap in these nanomaterials (Chen et al. 2010). Pt-doped BNNTs, unlike pristine and SW-defective BNNTs, are semiconducting.
4.5. Adsorption of gases onto Pt-doped SWCNTs
Discrete organometallic Pt complexes and metal surfaces alike can undergo coordination or adsorption to gas molecules. Hence, we expect similar reactivity with Pt atoms embedded within the sidewall of a carbon nanotube (Yeung et al. 2010).
Carbon monoxide is an important ligand for organometallic complexes and has demonstrated the ability to undergo physisorption onto metal surfaces (Orita et al. 2004). Although the C≡O triple bond of CO is polarized with a reactive lone-pair of electrons on the C, we imagined that adsorption would be possible via either C-end adsorption (a CO-adsorbed HSWCNT) or O-end adsorption (an OC-adsorbed HSWCNT, Figure 15). Both processes were found to be exothermic, with C-end adsorption liberating 41.2 kcal/mol while O-end adsorption only produced 7.0 kcal/mol (Table 1). This coordination is a coordinate dative bond, in which the C atom donates its pair of electrons into a metal
Since Pt complexes commonly hosts six ligands in its coordination sphere, we explored the possibility of multiple adsorption. We successfully identified a structure in which two CO molecules underwent coordination to the Pt center through C-end adsorption (Figure 15). The (CO)2-adsorbed HSWCNT was formed with a further release of energy (36.8 kcal/mol per CO molecule) and displayed almost identical orientation of both adsorbates. The second adsorption triggered an increase in distance between the Pt atom and the adsorbate to 2.00 Å, while the net charges on each CO molecule decreased to −0.05. Attempts to probe the possibility of triple adsorption did not afford structures in which the CO molecules were bound strongly to the Pt atom via C-end adsorption; instead, a third additional molecule of CO displayed a weak interaction with the nanotube sidewall. This process is uphill in energy from the doubly-adsorbed intermediate. Clearly, the steric bulk of the nanotube precludes the possibility of triple adsorption.
Nitrogen monoxide is not commonly encountered in coordination chemistry, unlike its related charged cousins NO+ and NO–, but are known to interact with Pt surfaces (Backus et al. 2004). In analogy to CO-adsorption, coordination between the Pt atom and the adsorbate can take place via N-end adsorption or O-end adsorption. Our calculations revealed that NO-adsorption is energetically preferential to ON-adsorption (Figure 15). In all geometries examined, the quartet spin state exhibited higher energy than doublet states (which can arise from either singlet or triplet Pt-doped SWCNT starting materials). The adsorption of NO onto the Pt atom embedded in the nanotube results in a complex bearing a charge of 0.99 on the Pt center and an increased HOMO−LUMO gap to 0.84 eV. Multiple adsorption was observed to occur in an unsymmetrical fashion in which one of the O atoms of the adsorbate molecules points away from the surface of the nanotube sidewall. This process is less exothermic than single adsorption, and consequently, simultaneous coordination of three molecules of NO was not considered.
Ammonia is a common N-containing ligand for Pt complexes, including the famous chemotherapy drug cisplatin, PtCl2(NH3)2 (Boulikas & Vougiouka 2003). Heterogeneous Pt surfaces are critical to NH3 chemistry, such as in the industrial oxidation of NH3 to NO in nitric acid production. Unlike CO and NO, however, NH3 does not exhibit a low-lying
|(CO)2||Singlet||−73.7||2.00, 2.00||1.19, 1.19||0.83||−0.05, −0.05||−0.49|
|Triplet||−59.0||2.00, 2.00||1.19, 1.19||0.78||−0.02, −0.02||−0.49|
|(CO)3||Singlet||−71.4||1.98, 2.00, 3.13||1.19, 1.19, 1.19||0.77||0.01, −0.01, −0.06||−0.37|
|Triplet||−73.7||2.03, 2.03, 2.41||1.18, 1.18, 1.19||0.76||0.05, 0.05, −0.13||−0.46|
|(NO)2||Singlet||−69.9||2.10, 2.12||1.24, 1.24||0.99||−0.24, −0.28||−0.36|
|Triplet||−77.8||2.12, 2.12||1.24, 1.24||0.99||−0.25, −0.25||−0.35|
|(NH3)2||Singlet||−57.1||2.27, 2.27||N/A||0.92||0.18, 0.18||−0.48|
|Triplet||−55.3||2.26, 2.26||N/A||0.86||0.19, 0.19||−0.49|
|(N2)2||Singlet||−43.9||2.16, 2.16||1.16, 1.16||0.93||−0.09, −0.09||−0.42|
|Triplet||−41.7||2.16, 2.16||1.16, 1.16||0.89||−0.09, −0.09||−0.41|
Nitrogen gas is distinct from the aforementioned adsorbates because of its lack of inherent polarity. If our Pt-doped nanotubes will be applied as nanosensors, the ability to detect simple and unpolarized small molecules is critical. The interaction between N2 and Pt surfaces is important to the industrial fixation of nitrogen via the Haber-Bosch process. In transition metal complexes, N2 can coordinate with either an end-on orientation (with the N atom acting as a
Hydrogen gas is the lightest diatomic molecule. Activation of H2 with Pt has found tremendous application in organic synthesis in the catalytic hydrogenation of alkenes and alkynes. Since our Pt-doped SWCNT has the capability of binding linear diatomic molecules, we reasoned that either H2 physisorption or chemisorption is possible. With our (5,5) C69H20Pt nanotube model, we obtained a geometry in which H–H bond cleavage occurred. In fact, a distance of 2.16 Å was observed between the two H atoms. The energetic preference for this reaction was −11.32 kcal/mol. In the optimized structure, the HOMO−LUMO gap was 0.70 eV, and a charge of 0.77 was present on the Pt atom, while 0.34 had transferred to the chemisorbed H2. (For other studies of H2 adsorption, see section 4.7.)
Carbon-carbon multiple bonds are excellent substrates for coordination to transition metals. In particular, the adsorption of C=C and C≡C bonds to Pt surfaces is an important process to catalytic hydrogenation reactions. To this end, we considered the adsorption of the simplest two-carbon alkene ethylene (C2H4) onto the (5,5) Pt-doped SWCNT model and found that 26.4 kcal/mol were released upon physisorption. The HOMO−LUMO gap increased to 0.88 eV in this case and the observed C=C bond distance was 1.43 Å. A net negative charge of –0.25 on the adsorbate was determined. When we optimized structures involving the simplest two-carbon alkyne acetylene (C2H2), we observed a strong interaction between the adsorbate and the HSWCNT. Alkynes are known to interact with transition metals through weak donation of
4.6. Applications of Pt-doped SWCNTs: Chemical sensors and nanoelectronics
Because of the ability for Pt-doped SWCNTs to adsorb different gases, it is reasonable to consider using these nanomaterials as chemical sensors. Developing a nanodevice capable of sensing the presence of various analytes depends primarily upon the ability to monitor minor changes in electronic structure, such as by measuring conductance across a nanowire. Designing new nanosensory technology for molecules including CO, NO, NH3, and H2 would be worthwhile (Rouxinol et al. 2010; Wang & Yeow 2009).
The first CNT gas sensor was reported by Kong, in which a semiconducting SWCNT acted as a channel to conduct the source-drain current in a field-effect transistor (FET, Kong et al. 2000). In a typical FET, the SWCNT connects the source and drain, and current is passed by applying an external voltage. The surface of the SWCNT is exposed to the atmosphere, hence allowing detection to take place (Rouxinol et al. 2010; Wang & Yeow 2009). Current is measured as a function of bias voltage (VB) and gate voltage (VG).
A variant of this design involves interdigitated electrodes (IDE). In a system developed by Li (Li et al. 2003), a solution casting process was used to prepare a device containing a network or mesh of SWCNTs on a Ti and Au IDE on a layer of silicon dioxide (SiO2). Drop-deposition of the nanotubes was the method of choice for delivery. This nanosensor combines the advantages of single nanotube transistors and film-based sensors since there is a large density of nanotubes present on the IDE and the array configuration provides excellent electrical contact between the SWCNTs and the electrodes while maintaining good accessibility for gas adsorption.
A complementary strategy known as the resonant-circuit sensor (RCS) method was described by Chopra (Figure 16, Chopra et al. 2002). In this scenario, carbon nanotubes are adsorbed onto a Cu resonator and irradiated by a microwave signal from a radio frequency transmitter. As a result of interaction with the sensor resonator, a strong signal is generated at its resonant frequency. Detection of analytes hence depends on measuring the shift of the frequency between the received signal and the transmitted signal.
In devices in which measurements of conductivity form the basis of quantitative analysis, minor fluctuations in electronic structure can be evaluated by considering the amount of charge transfer that takes place between the SWCNT and the small molecule adsorbate. Analysis of the HOMO−LUMO gap may also provide some insight. Peng and co-workers have described that charge transfer resulting from adsorption can change conductance along the axis as follows:
In our investigations (Yeung et al. 2008), the magnitude of charge transfer between adsorbate and the Pt atom is relatively small. However, it has been demonstrated a change of 0.28 is sufficient for being experimentally measurable. We predict that extending our model Pt-doped SWCNTs in either direction
|Analyte||Charge transfer||GHL (eV)||∆GHL|
Other than chemical sensors, Pt-doped SWCNTs may be applied to nanoelectronics. There have already been significant studies involving the utilization of CNTs as FETs, optoelectronic devices, and nanoelectromechanical systems (NEMS, Park 2004; Srivastava et al. 2003; Fuhrer 2003; Tsukagoshi et al. 2002). Technology using CNTs in FETs has already been commercialized (e.g., Infineon Technologies). In this specific FET, which features a back-gate, the CNT is situated at the top of the electrodes, separated from each other by a dielectric spacer to the back-gate. The conductive nanochannel hence provides an electrical connection between the source and drain electrodes and acts as a molecular wire. Applying these devices to more complex components such as nonvolatile molecular memory elements is a rapidly advancing field.
Because Pt-doped SWCNTs undergo conductivity changes when exposed to different types of gases, we envision the design of a new element of control in nanoelectronics in which varying the gas atmosphere will allow control of electrical current. For instance, if the conductance of a CNT nanowire is too high, introducing an atmosphere of CO should provide an immediate increase in resistivity and a decreased current. This effect would be compounded if the nanotube backbone is substitutionally doped at multiple sites. The key advantage to this type of electronic manipulation is the ability to control conductivity and resistivity
4.7. Adsorption of H2 onto Pt-doped SWCNTs and BNNTs
The incorporation of Pt into the sidewall of CNTs provides a unique chemical reactivity, particularly with small molecules, that is otherwise not possible. In our studies of H2 adsorption (Yeung et al. 2008), our (5,5) C69H20Pt model revealed a strong interaction between hydrogen and the Pt atom, resulting in a chemisorptive process in which the two H atoms became split. We also pursued investigations of Pt-doped nanorods capped with fullerenes and their ability to perform H–H bond cleavage (Tian et al. 2006). To our surprise, with the larger C169Pt nanorods, both cap-doped HSWCNTs underwent physisorption with H2, releasing only 2.0 kcal/mol of energy. We were pleased to find, however, that wall-doped nanorods performed a similar chemisorption as predicted by our H-capped model.
The isoelectronic Pt-doped BNNTs was also considered in H2 adsorption (Li et al. 2009). In their work, up to three equivalents of H2 can undergo physisorption to the Pt center. This is in stark contrast to our Pt-doped SWCNTs which can perform chemisorption. Clearly, the electronic nature of the carbon backbone plays a role in determining the chemical reactivity of the Pt atom.
4.8. Applications of H2 adsorption onto Pt-doped SWCNTs and BNNTs: Hydrogen storage and nanocatalytic hydrogenations
The use of CNTs in hydrogen storage remains an active area of research (Yao 2010). For instance, defective CNTs and their ability to undergo adsorption of H2 has also been investigated (Gayathri et al. 2007). If Pt-doped SWCNTs and Pt-doped BNNTs are to be used as hydrogen storage materials, then their ability to adsorb H2 reversibly becomes important. As we have described above, Pt-doped SWCNTs (especially wall-doped) tend to undergo chemisorption with H2 and release of hydrogen may require external input of energy (Yeung et al. 2010; Tian et al. 2008). On the other hand, a reversible interaction between Pt-doped BNNTs and hydrogen appears to be much more favorable. Careful tuning of the electronic properties of the Pt atom will be necessary to achieve the right balance to provide facile and reversible adsorption and desorption. In an infinitely long SWCNT with numerous Pt dopants, we expect that efficiency will be improved.
Perhaps more interesting than H2 storage is the ability for Pt to activate H2. While many transition metals are known to cleave hydrogen homolytically, forming a formal metal dihydride, the substitutional doping strategy that we have described is of particular interest because of potential use of these nanomaterials as catalysts for catalytic hydrogenation. We have already discovered that C=C double bonds (in C2H4) bind reversibly to the Pt atom of Pt-doped SWCNTs, while H2 undergoes complete dissociation. At an appropriate doping concentration and geometry, we envision two Pt atoms working together to perform hydrogenation of alkenes such as ethylene. On the first Pt atom, H2 would undergo H–H bond breaking via oxidative addition. Simultaneously, on the second Pt atom, one molecule of alkene can bind transiently. Because of the weak interaction, it is reasonable to presume that the alkene can insert into the Pt–H bond and form a new Pt–C bond. Finally, reductive elimination will furnish the reduced alkane product. Should this transformation be possible, it would be a modern variant of Pt metal catalyzed hydrogenation. The only reason that catalytic hydrogenation would become possible using nanotubes is because of the innate chemical reactivity of Pt. Hence, substitutional doping may open the door for examining other types of nanocatalysis, one of which is described below.
4.9. Applications of Pt-doped SWCNTs: Lewis acidity and nanocatalysis
Pt-doped SWCNTs can undergo adsorption with CO (Yeung et al. 2007). Based on this reactivity, we investigated model alkylplatinum complexes through DFT, considering all possible trimethylplatinum species with formulae PtMe3(CO)
PtMe3+ is a known Lewis acid catalyst (Hsieh et al. 2007; Procelewska et al. 2005). Hence, we considered the use of Pt-doped SWCNTs as nanocatalysts (Yeung et al. 2011). To evaluate Lewis acidity, we first performed vibrational analyses on CO-adsorbed Pt complexes, since the C≡O stretch is an indicator for the level of backdonation from the metal center to the ligand. Next, the nuclear magnetic resonance (NMR) chemical shift (
Other than PtMe3+, we examined other Pt-based model systems (Figure 18) for Pt-doped SWCNTs, including PtPh3+, Pt-doped phenaline, Pt-doped sumanene, Pt-doped corannulene, and Pt-doped C24 fullerene (which exists as one of two isomers, involving either Pt substitution at a pentagon-pentagon-pentagon junction or PPP, or a hexagon-pentagon-pentagon junction or HPP). We were intrigued to additionally evaluate the role of the delocalized
By means of C≡O vibrational frequency analysis (Table 3), we found that Pt-doped (5,5) SWCNTs demonstrated net backdonation to CO (Yeung et al. 2010), while the corresponding (5,0) SWCNT system underwent adsorption with net donation of electron density from the adsorbate (Yeung et al. 2011). In contrast, all other model complexes evaluated have a tendency to deplete electron density from CO. Based on similar stretching frequencies of CO-adsorbed Pt-doped C24 and corannulene, higher levels of π-conjugation appear to have a positive impact on the ability to backbond to incoming ligands, leading to a tighter Pt–CO interaction (~2.00 Å). The most acidic complexes, however, are PtPh3+ and PtMe3+, which display weaker Pt–CO interactions (~2.11 Å). Based on this investigation, the predicted trend of Lewis acidity is as follows:
By means of NMR analysis (Table 4), we were surprised to observe decreased chemical shifts of the
|Pt-doped C24 PPP||250.6°||0.69||−31.6||−16.74||2.027||1.167||2017.3||0.32||0.17|
|Pt-doped C24 HPP||268.3°||0.66||−32.7||−17.59||1.995||1.166||2026.4||0.30||0.22|
|(5,0) Pt-doped SWCNT||292.2°||0.53||−36.0||−20.31||1.971||1.179||1949.8||0.12||0.12|
|Pt-doped C24 PPP/MA||1.254||1.472||1.363||−0.595||−0.266||6.30||0.05|
|Pt-doped C24 HPP/MA||1.245||1.479||1.359||−0.552||−0.250||6.39||0.14|
|(5,0) Pt-doped SWCNT/MA||1.276||1.441||1.385||−0.636||−0.317||5.62||−0.63|
By means of enhancing the reactivity of chemical reactions such as the Diels-Alder cycloaddition, we observed a surprising
The cyclohexene product formed in the Diels-Alder cycloaddition can exist as one of two diastereomeric compounds (Rulisek et al. 2005; Dewar & Pierini 1984). The so-called
More complex, novel nanosystems may even become possible. Because nanotubes are channels, we may one day be able to achieve nanoscale microfluidics. We can imagine a transition metal-doped SWCNT embedded within a much larger SWCNT. If this is possible, the nanochannels sitting between the two carbon backbones may provide enhanced chemical reactivity due to higher local concentrations of the reactive partners. In the ideal world, it may be possible that reactants be introduced at one end of a nanochannel and products come out of the other end. Cooperative catalysis between different transition metals may allow for unique types of catalysis that are not possible in bulk solutions, on flat surfaces, or at pointy small clusters. Needless to say, nanocatalysis remains an emerging field that will continue to develop in the years to come.
|Pt-doped C24 PPP||23.5||−4.0||22.6||−3.5||0.9||4.26||1.42|
|Pt-doped C24 HPP||23.5||−4.5||22.5||−4.2||1.0||5.44||2.99|
|(5,0) Pt-doped SWCNT||31.0||6.4||31.9||6.5||–0.9||0.21||1.6×10–3|
5. Concluding remarks
Within DFT, the rich chemistry of substitutionally doped SWCNTs has been investigated. We summarize our findings below:
A mono vacancy formed by removing a single C atom from the sidewall of a SWCNT rearranges to form a five-membered carbocycle and a single C atom with a dangling bond (i.e., the 5-1DB defect). 5-1DB defects are reactive with NO, liberating NO2 and N-doped SWCNTs, and with O3, generating O2 and O-doped SWCNTs.
Substitutional doping of SWCNTs with transition metals results in buckling of the nanotube sidewall with the larger atom protruding to the exterior.
Adsorption of gases onto Pt-doped SWCNTs is analogous to the coordination chemistry of monomeric Pt complexes. Because the nanotube sidewall provides much larger steric bulk, multiple adsorption is thermodynamically unfavorable. The ability for Pt atoms to perform physisorption and chemisorption depends strongly on the doping location. Adsorption results in a change in the electronic structure of Pt-doped SWCNTs.
Pt-doped SWCNTs exhibit Lewis acidity similar to that of simple alkyl- and arylplatinum complexes. Evaluation of Lewis acid strength can be done by measuring the stretching frequency of a bound molecule of CO or by 1H NMR studies of the β-H of Lewis acid/Lewis base complexes formed with α,β-unsaturated carbonyl compounds. However, because the nanotube provides larger steric bulk than simple alkyl- and arylplatinum complexes, the ability to activate a substrate for conventional catalysis may be impeded, but alternative catalytic activities might be released instead.
Transition metal-doped SWCNTs have yet to be prepared experimentally. In this Chapter, we have provided a comprehensive overview of the potential of these nanomaterials and their applications in nanosensing, nanoelectronics, and nanocatalysis. Our initial investigations here should provide inspiration and guidance to experimentalists in their own endeavors.
We thank the Natural Sciences and Engineering Research Council (NSERC) of Canada for financial support. WestGrid and C-HORSE have provided the necessary computational resources. C.S.Y. gratefully acknowledges NSERC for an Undergraduate Student Research Award.
Ajayan P. M. Ravikumar V. Charlier J. C. 1998Surface reconstructions and dimensional changes in single-walled carbon nanotubes. Phys. Rev. Lett., 81 1437 1440.
Ajayan P. M. 1999Nanotubes from carbon. , 99 1787 1800.
Avouris P. Freitag M. Perebeinos V. 2008Carbon-nanotube photonics and optoelectronics. , 2 341 350.
Backus E. H. G. Eichler A. Grecea M. L. Kleyn A. W. Bonn M. 2004Adsorption and dissociation of NO on stepped Pt (533). , 121 7946 7954.
Becke A. D. 1988Density-functional exchange-energy approximation with correct asymptotic-behavior. , 38 3098 3100.
Berber S. Oshiyama A. 2006Reconstruction of mono-vacancies in carbon nanotubes: atomic relaxation vs. spin polarization. , 376-377, 272-275.
Bethune D. S. Kiang C. H. de Vries M. S. Gorman G. Savoy R. Vazquez J. Beyers R. 1993Cobalt-catalyzed growth of carbon nanotubes with single-atomic-layer walls. , 363 605 607.
Boulikas T. Vougiouka M. 2003Cisplatin and platinum drugs at the molecular level. , 10 1663 1682.
Branz W. Billas I. M. L. Malinowski N. Tast F. Heinebrodt M. Martin T. P. 1998Cage substitution in metal-fullerene clusters. , 109 3425 3430.
Bryning M. B. Islam M. F. Kikkawa J. M. Yodh A. G. 2005Very low conductivity threshold in bulk isotropic single-walled carbon nanotube-epoxy composites. , 17 1186 1191.
Buzea C. Blandino I. I. P. Robbie K. 2007Nanomaterials and nanoparticles: sources and toxicity. , 2, MR 17-MR172.
Caruso E. B. Petralia S. Conoci S. Giuffrida S. Sortino S. 2007Photodelivery of nitric oxide from water-soluble platinum nanoparticles. , 129 480 481.
Changgeng D. Jinlong Y. Rongsheng H. Kelin W. 2001Formation mechanism and structural and electronic properties of metal-substituted fullerenes C69M (M = Co, Rh, and Ir). , 64, 043201.
Chen Y. K. Liu L. V. Wang Y. A. 2010Density functional study of interaction of atomic Pt with pristine and Stone-Wales-defective single-walled boron nitride nanotubes. , 114 12382 12388.
Chen Y. K. Liu L. V. Tian W. Q. Wang Y. A. 2011Theoretical studies of transition-metal-doped single-walled carbon nanotubes. , 115 9306 9311.
Chiaretti M. Mazzanti G. Bosco S. Bellucci S. Cucina A. le Foche F. Carru G. A. Mastrangelo S. di Sotto A. Masciangelo R. Chiaretti A. M. Balasubramanian C. de Bellis G. Micciulla F. Porta N. Deriu G. Tiberia A. 2008Carbon nanotubes toxicology and effects on metabolism and immunological modification in vitro and in vivo. : Condens. Matter, 20, 474203.
Chico L. Santos H. Ayuela A. Jaskolski W. Pelc M. Brey L. 2010Unzipped and defective nanotubes: rolling up graphene and unrolling tubes. , 118 433 441.
Childs R. F. Mulholland D. L. Nixon A. 1982The Lewis acid complexes of α,β-unsaturated carbonyl and nitrile compounds. A nuclear magnetic resonance study. , 60 801 808.
Chopra S. Pham A. Gaillard J. Parker A. Rao A. M. 2002Carbon-nanotube-based resonant-circuit sensor for ammonia. , 80 4632 4634.
Collins P. G. Bradley K. Ishigami M. Zetti A. 2000Extreme oxygen sensitivity of electronic properties of carbon nanotubes. , 287 1801 1804.
Collins P. G. 2010Defects and disorder in carbon nanotubes, in The Oxford Handbook of Nanoscience and Nanotechnology, Oxford University Press: New York, NY, 2Chapter 2, 31 93.
Culotta E. Koshland Jr D. E. 1992NO news is good news. , 258 1862 1865.
Dapprich S. Komaromi I. Byun K. S. Morokuma K. Frisch M. J. 1999A new ONIOM implementation in Gaussian 98. 1. The calculation of energies, gradients and vibrational frequencies and electric field derivatives. , 462 1 21.
Dewar M. J. S. Pierini A. B. 1984Mechanism of the Diels-Alder reaction. Studies of the addition of maleic anhydride to furan and methylfurans. , 106 203 208.
Dewar M. J. S. Zoebisch E. G. Healy E. F. 1985AM1: A new general purpose quantum mechanical molecular model. , 107 3902 3909.
Ditchfield R. Hehre W. J. Pople J. A. 1971Self-consistent molecular orbital methods. 9. Extended Gaussian-type basis for molecular-orbital studies of organic molecules. , 54, 724.
Dunning Jr T. H. Hay P. J. 1976Gaussian basis sets for molecular calculations, in Modern Theoretical Chemistry, Plenum: New York, NY, 3 1 28.
Ewels C. Glerup M. Krstic V. 2010Nitrogen and boron doping in carbon nanotubes, in Doped Nanomaterials and Nanodevices, American Scientific Publishers: Valencia, CA, 3
Frisch, M. J., Trucks, G. W., Schlegel, H. B., Scuseria, G. E., Robb, M. A., Cheeseman, J. R., Montgomery, J. A., Vreven, T., Kudin, K. N., Burant, J. C., Milliam, J. M. Iyengar, S. S., Tomasi, J., Barone, V., Mennucci, B., Cossi, M., Scalmani, G., Rega, N., Petersson, G. A., Nakatsuji, H., Hada, M. Ehara, M., Toyota, K., Fukuda, R., Hasegawa, J., Ishida, M., Nakajima, T., Honda, Y., Kitao, O., Nakai, H., Li, X., Knox, J. E., Hratchian, H. P., Cross, J. B., Bakken, V., Adamo, C., Jaramillo, J., Gomperts, R., Stratmann, R. E., Yazyev, O., Austin, A. J., Cammi, R., Pomelli, C., Ochterski, J. W., Ayala, P. Y., Morokuma, K., Voth, G. A., Salvador, P., Dannenberg, J. J. Zakrzewski, V. G., Dapprich, S., Daniels, A. D., Farkas, O., Malick, D. K., Rabuck, A. D., Raghavachari, K., Foresman, J. B., Ortiz, J. V., Cui, Q., Baboul, A. G., Clifford, S., Coislowski, J., Stefanov, B. B., Liu, G., Liashenko, A., Piskorz, P., Komaromi, I., Martin, R. L., Fox, D. J., Keith, T., Al-Laham, M. A., Peng, C. Y., Nanayakkara, A., Challacombe, M., Gill, P. M. W., Johnson, B., Chen, W., Wong, M. W., Gonzalez, C. & Pople, J. A. 2003Gaussian 03, Revision B.05, Gaussian, Inc.: Wallingford CT.
Fuhrer M. S. 2003Single-walled carbon nanotubes for nanoelectronics, in Advanced Semiconductor and Organic Nano-Techniques (Part II), Academic Press: London, Chapter 6, 293 343.
Fukui K. 1982Role of frontier orbitals in chemical reactions. , 218 747 754.
Gayathri V. Geetha R. 2007Hydrogen adsorption in defected carbon nanotubes. , 13 53 59.
Golberg D. Bando Y. Huang Y. Terao T. Mitome M. Tang C. Zhi C. 2010Boron nitride nanotubes and nanosheets. , 4 2979 2993.
Glerup M. Krstic V. Ewels C. Holzinger M. Lier G. V. 2010Doping of carbon nanotubes, in Doped Nanoamterials and Nanodevices, American Scientific Publishers: Valencia, 3
Griffith O. W. Stuehr D. J. 1995Nitric oxide synthases: properties and catalytic mechanism. , 57 707 736.
Grinvald A. Hildesheim R. 2004VSDI: a new era in functional imaging of cortical dynamics. , 5 874 885.
Haddon R. C. Scott L. T. 1986π-Orbital conjugation and rehybridization in bridged annulenes and deformed molecules in general: π-orbital axis vector analysis. , 58 137 142.
Hay P. J. Wadt W. R. 1985Ab initio effective core potentials for molecular calculations- potentials for K to Au including the outermost core orbitals. , 82 299 310.
Hsieh V. de Crisci A. G. Lough A. J. Fekl U. 2007Lewis-acidity of trimethylplatinum(IV) with labile oxygen-donor ligands. , 26 938 944.
Hu C. Hu S. 2009Carbon nanotube-based electrochemical sensors: principles and applications in biomedical systems. , 2009, 187615.
Iijima S. 1991Helical microtubules of graphitic carbon. , 354 56 58.
Iijima S. Ichihashi T. 1993Single-shell carbon nanotubes of 1-nm diameter. , 363 603 605.
Javey A. Guo J. Wang Q. Lundstrom M. Dai H. 2003Ballistic carbon nanotube field-effect transistors. , 424 654 657.
Karakoti A. S. Hench L. L. Seal S. 2006The potential toxicity of nanomaterials- the role of surfaces. , 58 77 82.
Karousis N. Tagmatarchis N. Tasis D. 2010Current progress on the chemical modification of carobn nanotubes. , 110 5366 5397.
Kong J. Franklin N. R. Zhou C. Chapline M. G. Peng S. Cho K. Dai H. 2000Nanotube molecular wires as chemical sensors. , 287 622 625.
Kong J. Chapline M. G. Dai H. 2001Functionalized carbon nanotubes for molecular hydrogen sensors. , 13 1384 1386.
Kong Q. Zhuang J. Xu J. Shen Y. Li Y. Zhao L. Cai R. 2003Contrasting behaviors of metal fullerides C60Rhx and C60Mx (M = La, Y) in the metallofullerrene formation by laser ablation. , 107 3670 3677.
Kuczkowski R. L. 1992The structure and mechanism of formation of ozonides. , 21 79 83.
Lam C. W. James J. T. Mc Cluskey R. Arepalli S. Hunter R. L. 2006A review of carbon nanotube toxicity and assessment of potential occupational and environmental health risks. , 36 189 217.
Laszlo P. Teston M. 1990Determination of the acidity of Lewis acids. , 112 8750 8754.
Lee C. Yang W. Parr R. G. 1988Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density. , 37 785 789.
Li C. Thostenson E. T. Chou T. W. 2008Sensors and actuators based on carbon nanotubes and their composites: a review. , 68 1227 1249.
Li J. Lu Y. Ye Q. Cinke M. Han J. Meyyappan M. 2003Carbon nanotube sensors for gas and organic vapor detection. , 3 929 933.
Li J. Jia G. Zhang Y. 2007Chemical anisotropies of carbon nanotubes and fullerenes caused by the curvature directivity. , 132 6430 6436.
Li X. M. Tian W. Q. Huang X. R. Sun C. S. Jiang L. 2009Adsorption of hydrogen on novel Pt-doped BN nanotubes. , 901 103 109.
Liu L. V. Tian W. Q. Wang Y. A. 2006Chemical reaction of nitric oxides with the 5-1DB defect of the single-walled carbon nanotube. , 110 1999 2005.
Liu L. V. Tian W. Q. Wang Y. A. 2006aOzonization at the vacancy defect site of the single-walled carbon nanotube. , 110 13037 13044.
Liu L. V. Tian W. Q. Wang Y. A. 2009Ab initio studies of vacancy-defected fullerenes and single-walled carbon nanotubes. , 109 3441 3456.
Lu X. Chen Z. 2005Curved pi-conjugation, aromaticity, and the related chemistry of small fullerenes (<C60) and single-walled carbon nanotubes. , 105 3643 3696.
Menzel L. Kosterev A. A. Curl R. F. Tittel F. K. Gmachi C. Capasso F. Sivco D. L. Baillargeon J. N. Hutchinson A. L. Cho A. Y. Urban W. 2001Spectroscopic determination of biological NO with a quantum cascade laser. , 72 859 863.
Miller M. R. Megson I. L. 2007 Recent developments in nitric oxide donor drugs., 151 305 321.
Moniruzzaman M. Winey K. I. 2006 Polymer nanocomposites containing carbon nanotubes. , 39 5194 5205.
Nel A. Xia T. Maedler L. Li N. 2006 Toxic potential of materials at the nanolevel. , 311 622 627.
Nevidomskyy A. H. Csanyi G. Payne M. C. 2003 Chemically active substitutional nitrogen impurity in carbon nanotubes., 91, 105502.
Oberdorster G. Stone V. Donaldson K. 2007 Toxicology of nanoparticles: a historical perspective. , 1 2 25.
Orita H. Itoh N. Inada Y. 2004All electron scalar relativistic calculations on adsorption of CO on Pt(111) with full-geometry optimization: a correct estimation for CO site-preference. , 384 271 276.
Park J. Y. 2004Nanoelectronics/mechanics with carbon nanotubes.
Peng S. Cho K. 2003 Ab initio study of doped carbon nanotube sensors. , 3 513 517.
Perdew J. P. Burke K. Ernzerhof M. 1996 Generalized gradient approximation made simple. , 77 3865 3868.
Perdew J. P. Burke K. Wang Y. 1996a Generalized gradient approximation for the exchange-correlation hole of a many-electron system. , 54 16533 16539.
Poblet J. M. Munoz J. Winkler K. Cancilla M. Hayashi A. Lebrilla C. B. Balch A. L. Winkler K. 1999 Geometric and electronic structure of metal-caged fullerenes, C59M (M = Pt, Ir) obtained by laser ablation of electrochemically deposited films., 493 494.
Procelewska J. Zahl A. Liehr G. van Eldik R. Smythe N. A. Williams B. S. Goldberg K. I. 2005Mechanistic information on the reductive elimination from cationic trimethylplatinum(IV) complexes to form carbon-carbon bonds. , 44 7732 7742.
Rappe A. K. Casewit C. J. Colwell K. S. Goddard I. I. I. W. A. Skiff W. M. 1992 UFF, a full periodic-table force-field for molecular mechanics and molecular-dynamics simulations. , 114 10024 10035.
Reed A. E. Curtiss L. A. Weinhold F. 1988 Intermolecular interactions from a natural bond orbital, donor-acceptor viewpoint. , 88 899 926.
Rouxinol F. P. Gelamo R. V. Moshkalev S. A. 2010 Gas sensors based on decorated carbon nanotubes, in Carbon Nanotubes. InTech, Chapter 19, 357 374.
Rulisek L. Sebek P. Havlas Z. Hrabal R. Capek P. Svatos A. 2005 An experimental and theoretical study of stereoselectivity of furan-maleic anhydride and furan-maleimide Diels-Alder reactions., 70 6295 6302.
Schipper M. L. Nakayama-Ratchford N. Davis C. R. Kam N. W. S. Chu P. Liu Z. Sun X. Dai H. Gambhir S. S. 2008A pilot toxicology study of single-walled carbon nanotubes in a small sample of mice. , 3 216 221.
Schlegel H. B. Millam J. M. Iyengar S. S. Voth G. A. Scuseria G. E. Daniels A. D. Frisch M. J. 2001Ab initio molecular dynamics: propagating the density matrix with Gaussian orbitals. , 114 9758 9763.
Serp P. Corrias M. Kalck P. 2003 Carbon nanotubes and nanofibers in catalysis. , 253 337 358.
Singh R. Pantarotto D. Lacerda L. Pastorin G. Klumpp C. Prato M. Bianco A. Kostarelos K. 2006 Tissue biodistribution and blood clearance rates of intravenously administered carbon nanotube radiotracers. , 103 3357 3362.
Sinha N. Ma J. Yeow J. T. W. 2006Carbon nanotube-based sensors. , 6 573 590.
Sonia K. Niranjan M. 2010Quantum conductance of defected carbon nanotubes. , 1324 415 418.
Sparta M. Borve K. J. Jensen V. R. 2006 Structure and stability of networked metallofullerenes of the transition metals. , 110 11711 11716.
Srivastava D. Chenyu W. Cho K. 2003 Nanomechanics of carbon nanotubes and composites. , 56 215 230.
Srivastava D. Menon M. Daraio C. Jin S. Sadanadan B. Rao A. M. 2004Vacancy-mediated mechanism of nitrogen substitution in carbon nanotubes. , 69, 153414.
Stewart J. J. P. 1989 Optimization of parameters for semiempirical methods. I. Method. , 10 209 220.
Stone A. J. Wales D. J. 1986Theoretical studies of icosahedral footballene sixty-carbon-atom molecules and some related species. , 128 501 503.
Tasis D. Tagmatarchis N. Bianco A. Prato M. 2006Chemistry of carbon nanotubes. , 106 1105 1136.
Tenderholt A. 2005, Version 1.1.
Tian W. Q. Liu L. V. Wang Y. A. 2006 Electronic properties and reactivity of Pt-doped carbon nanotubes. , 8 3528 3539.
Tsukagoshi K. Yoneya N. Uryu S. Aoyagi Y. Kanda A. Ootuka Y. Alphenaar B. W. 2002Carbon nanotube devices for nanoelectronics. , 323 107 114.
Wang J. Lee C. H. Yap Y. K. 2010 Recent advances in boron nitride nanotubes. Nanoscale, 2 2028 2034.
Wang Y. Yeow J. T. W. 2009 A review of carbon nanotubes-based gas sensors. , 493904.
Wheatley P. S. Butler A. R. Crane M. S. Fox S. Xiao B. Rossi A. G. Megson I. L. Morris R. E. 2006NO-releasing zeolites and their antithrombotic properties. , 128 502 509.
White C. T. Todorov T. N. 1998 Carbon nanotubes as long ballistic conductors. , 393 240 242.
Wolinski K. Hilton J. F. Pulay P. 1990 Efficient implementation of the gauge-independent atomic orbital method for NMR chemical shift calculations. , 112 8251 8260.
Yang S. H. Shin W. H. Lee J. W. Kim S. Y. Woo S. I. Kang J. K. 2006 Interaction of a transition metal atom with intrinsic defects in single-walled carbon nanotubes., 110 13941 13946.
Yao Y. 2010 Hydrogen storage using carbon nanotubesin Carbon Nanotubes, InTech, Chapter 28, 543 562.
Yeung C. S. Liu L. V. Wang Y. A. 2007 Novel nanotube-coordinated platinum complexes. , 4 1108 1119.
Yeung C. S. Liu L. V. Wang Y. A. 2008 Adsorption of small gas molecules onto Pt-doped single-walled carbon nanotubes. , 112 7401 7411.
Yeung C. S. Wang Y. A. 2011 Lewis acidity of Pt-doped buckybowls, fullerenes, and single-walled nanotubes. J. Phys. Chem. C, 115 7153 7163.
Zhuang H. L. Zheng G. P. Soh A. K. 2008 Interactions between transition metals and defective carbon nanotubes. , 43 823 828.