Use of discrete event simulation in different manufacturing system life-cycle phases, based on Heilala et al. (2001, \n\t\t\t\t\t\t\t\t2007\n\t\t\t\t\t\t\t).
\r\n\tThis book aims to provide a comprehensive overview for the robotic interaction including dynamic modeling and control aspects in order to provide a guide for designers of robotic controllers. Furthermore, it helps the roboticists to select the right model, control architecture and accordingly design the appropriate control algorithm for robotic interactive task with respect to the implemented robotic technology.
",isbn:null,printIsbn:null,pdfIsbn:null,doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!1,isSalesforceBook:!1,isNomenclature:!1,hash:"9531ee9c84fd27d3e5f84caf963632b3",bookSignature:"Dr. Ali Leylavi Shoushtari and Prof. Andon Venelinov Topalov",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/8359.jpg",keywords:"Robotic physical interaction, Human - robot interaction, Kinematics, Dynamics, Interactive tasks, Motion planning, Anthropomorphic manipulators, Compliant joint, Back-drivability, Control approaches, Safety in robotic interaction, Soft robotics",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:0,numberOfDimensionsCitations:0,numberOfTotalCitations:0,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"July 9th 2018",dateEndSecondStepPublish:"July 30th 2018",dateEndThirdStepPublish:"September 28th 2018",dateEndFourthStepPublish:"December 17th 2018",dateEndFifthStepPublish:"February 15th 2019",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"4 years",secondStepPassed:!0,areRegistrationsClosed:!0,currentStepOfPublishingProcess:5,editedByType:null,kuFlag:!1,biosketch:null,coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"266351",title:"Dr.",name:"Ali",middleName:null,surname:"Leylavi Shoushtari",slug:"ali-leylavi-shoushtari",fullName:"Ali Leylavi Shoushtari",profilePictureURL:"https://mts.intechopen.com/storage/users/266351/images/system/266351.png",biography:"He received his PhD in Biorobotics from Scuola Superiore Sant\\'Anna, Pisa and MSc in Mechatronics from South Tehran Branch, Azad University. During his PhD he designed and developed Bio-inspired inverse kinematic algorithm for anthropomorphic robotic manipulators, and designed and developed a unified motion planning and compliance control framework for upper-arm Neuro-rehabilitation robotic task. Persued research on design, fabrication and modeling or soft origami actuators in Center for Micro-BioRobotics (CMBR), IIT as a postdoctoral researcher. In 2019, the Farm Tech Group joined Wageningen University & Research and is currently working on soft adhesive grippers for delicate crop handling. The project is in collaboration with the Department of Experimental Zoology, WUR to take inspiration from adhesive properties of tree frog fingertip and Department of Physical Chemistry and Soft Matter in order to develop fabrication methods for soft actuators and sensor.",institutionString:"Wageningen University & Research",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"Wageningen University & Research",institutionURL:null,country:{name:"Netherlands"}}}],coeditorOne:{id:"147800",title:"Prof.",name:"Andon",middleName:"Venelinov",surname:"Topalov",slug:"andon-topalov",fullName:"Andon Topalov",profilePictureURL:"https://mts.intechopen.com/storage/users/147800/images/system/147800.jpeg",biography:"Dr. Andon V. Topalov received the MSc degree in Control Engineering from the Faculty of Information Systems, Technologies, and Automation at Moscow State University of Civil Engineering (MGGU) in 1979. He then received his PhD degree in Control Engineering from the Department of Automation and Remote Control at Moscow State Mining University (MGSU), Moscow, in 1984. From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. He has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. His current research interests are in the fields of intelligent control and robotics.",institutionString:"Technical University of Sofia, branch in Plovdiv",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"0",institution:null},coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"22",title:"Robotics",slug:"physical-sciences-engineering-and-technology-robotics"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"247041",firstName:"Dolores",lastName:"Kuzelj",middleName:null,title:"Ms.",imageUrl:"https://mts.intechopen.com/storage/users/247041/images/7108_n.jpg",email:"dolores@intechopen.com",biography:"As an Author Service Manager my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review, to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. 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The interrelations between manufacturing systems and processes are becoming more complex and the amount of data for decision making is growing. Manufacturing, engineering and production management decisions involve the consideration of multiple parameters. These often complex, interdependent factors and variables are too many for the human mind to cope with at one time. Agile production needs a management and evaluation tool for production changes, manufacturing system development, configuration and operations planning. A decision support system based on manufacturing simulation is one suitable solution.
\n\t\t\tDiscrete Event Simulation (DES) has mainly been used as a production system analysis tool to evaluate new production system concepts, layout and control logic. Recent development has enhanced DES models for use in the day-to-day operational production planning of manufacturing facilities. These "as built" models provide manufacturers with the ability to evaluate the capacity of the system for new orders, unforeseen events such as equipment downtime, and changes in operations. After a simulation model has been built, experiments are performed by changing the input parameters and predicting the response. Experimentation is normally carried out by asking "what-if" questions and using the model to predict the likely outcome.
\n\t\t\tA simulation-based Decision Support System (DSS) can be used to augment the tasks of planners and schedulers to run production more efficiently (Figure 1). Some of the benefits of implementing an operational simulation scheduling system include: less effort required to plan day-to-day scheduling, customer order due date conformance, synchronisation of flow through the plant, minimisation of set-ups/changeovers, early warnings of potential problems, checks of critical resources and materials, and, naturally, “what-if” scenario analysis for capacity planning.
\n\t\t\tAlthough dedicated software packages are currently available, there are limited examples of the use of simulation tools in the operational planning of manufacturing. This chapter also sheds light on development challenges and current development efforts to solve these challenges for this data and model-driven DSS. The major challenges are: 1) data integration, 2) automated simulation model creation and updates, and 3) visualisation of results for interactive and effective decision making.
\n\t\t\tSimulation and modelling-based system helps operators in daily operations planning.
The costs of integrating simulation systems with other manufacturing applications are high; there is always a need to transfer and share data between the simulation and other manufacturing software applications. Custom-built proprietary interfaces require extensive customisation and the current standardisation landscape for system integration is challenging. Development efforts to solve this problem are ongoing. Naturally, if managers are using a simulation model to plan operations, the model must be precise enough and kept up to date. There is a need for permanent, always on, synchronised factory models that can be created automatically on-demand from ERP and other data sources. Users need fast analysis and methods to perform “what-if” scenarios. Simulation results can provide suggestions for feasible and optimised finite scheduling, but the human in the loop will make the final decision. The users also need a visually effective user interface. Visual analytics provides visual and interactive tools for analytical reasoning and decision making from data. The basic idea is to combine the strengths of automatic data analysis with the visual perception and analysis capabilities of the human user. The use of simulation with an easy-to-use graphical user interface provides tools and methods for manufacturing scenario evaluation, scheduling optimisation, and production planning even for simulation non-experts. Some of the past case studies are described to illustrate the system solution. The benefits of simulation-based DSS in the customer-driven manufacturing domain and the suitable user groups are discussed.
\n\t\t\tA manufacturing system is made up of entities (input and outputs), activities, resources and controls. It encompasses processes but also includes the resources and controls for carrying them out, as shown in Figure 2. Manufacturing system design involves a number of interrelated subjects, including tooling strategy, material handling systems, system size, process flow configuration, flexibility needed for future engineering changes or capacity adjustments, and space strategy.
\n\t\t\t\tThere are many challenging factors: the need to boost system performance due to global competition and the growing complexity of both the manufacturing systems and products to be manufactured. The operations planning and capacity management of these complex manufacturing systems are indeed challenging. Productivity enhancement is also a major objective for manufacturing enterprises. Manufacturers are experiencing fluctuating market demand for their products, with ever shorter lead times and smaller but more frequent order quantities, accompanied by increasingly frequent changes in product specifications - even during manufacture. Product life cycles are shorter and it is becoming more difficult to forecast demand. All this requires agility and flexibility on the part of the factory, which runs counter to the built-in inertia and the gravitational force to \'conduct business as usual’, combined with the limited ability of management to reconsider decisions almost ‘in real time’.
\n\t\t\tManufacturing system (modified from Harrel and Tumay, 1995).
Customers define the business. They want high-quality personalised products. Time-to-customer, punctuality and throughput time are important competitive factors in customer-driven manufacturing. The products are usually complex systems consisting of components that are manufactured in different factories, sometimes in different countries. The whole production network - including both component manufacturing and assembly - has to be flexible and able to react to changes in production capacity requirements.
\n\t\t\t\tManufacturing is performed on the basis of customer orders. Each order can be unique, consisting of different components, and batch sizes vary. Naturally, the throughput times of the products may differ from one another. A new order is a ‘disturbance’ to the current situation in production. All this makes the design and management of production networks a complex task. One of the risks is the occurrence of dynamic bottlenecks, in which the demand for capacity in one particular operation suddenly turns out to be excessive and the resulting delays reverberate throughout the rest of the production system. The changing location of bottlenecks depends on the status of production resources, equipment, materials, human operators and orders in production.
\n\t\t\t\tFeatures of customer-driven manufacturing:
\n\t\t\t\tPromises to the customer must be kept (always); Time, Quality and Cost
Need for speed and flexibility due to dynamic global competition
Order book shrinks while delivery times shorten
Outsourcing, supply and value networks
Productivity improvements from supply chain management and coordination.
The order entry point defines the customers’ influence on the features of the product:
\n\t\t\t\tMake-to-Stock (MTS): the customer selects a product from stock and the product is shipped to the customer. No customisation.
Assemble-to-Order (ATO): the customer order initiates the assembly from components and modules in stock. Customisation is based on customer requirements in assembly before delivery.
Make-to-Order (MTO): the customer order initiates material purchases, component and module manufacturing and assembly of the product.
Engineer-to-Order (ETO): customer specifications initiate the engineering process before material purchases are made and component manufacturing and assembly are started.
The deeper the order entry point is into the manufacturing process, the more challenging and complex the production planning. The case studies of operations planning provided in this chapter have features of ATO, MTO and ETO. In current global competition and in lean and agile manufacturing, material stocks are kept as small as possible, while expensive resource utilisation should be kept as high as possible. Production personnel must seek a balance between customer orders and limited resources. Every new order disturbs the current balance (Figure 3). The resources are equipment, machinery, human operators as well the material needed for the manufacturing operations.
\n\t\t\t\tProduction balancing between orders and limited resources.
The accuracy of order date delivery promises is a key element in customer satisfaction. One of the important decisions in production planning is the scheduling and synchronisation of activities, resources and material flow. Old static production planning methods are not adequate; production planners need accurate and dynamic models of production, i.e. a simulation model using production network and real shop floor data in near real time.
\n\t\t\t\tIn this complex world, the development of decision support for human operators and information management is a key asset in managing “better-faster-cheaper” competition. Simulation analysis with real data provides forecasts on the basis of the given input values. This gives production managers the time to react to potential problems and evaluate alternatives. A better balance between multiple parallel customer orders and finite resources can be found.
\n\t\t\tA Decision Support System (DSS) is an interactive computer-based system or subsystem intended to help decision makers use communications technologies, data, documents, knowledge and/or models to identify and solve problems, complete decision process tasks, and make decisions. Decision Support System is a general term for any computer application that enhances a person or group’s ability to make decisions. In general, Decision Support Systems are a class of computerised information systems that support decision-making activities. Five more specific DSS types include (Power 2009)
\n\t\t\tCommunications-Driven DSS,
Data-Driven DSS,
Document-Driven DSS,
Knowledge-Driven DSS and
Model-Driven DSS.
There are multiple decision-making aims in the manufacturing system domain. Strategic and tactical aims focus on the design or selection of a new manufacturing system or the improvement of the existing manufacturing system, and the planning time horizon is years or months (Figure 4). Operational aims, which involve the running of the existing system, have a much shorter time frame – days, hours or minutes to solve problems in manufacturing.
\n\t\t\t\tThe planning horizon and aims in production engineering and management.
The production engineering and management decision is typically based on the data and information available at the moment of the decision. Operators and managers can use all the quantitative data at their disposal, but they still have to distrust it and use their own intelligence and judgement. Production managers, sales and customer service engineers have traditionally made their decisions based on the following data, information and factors:
\n\t\t\t\tOwn intuition, long experience and asking the ”experts”
Use of tables and handbooks, given static information, order books, legacy systems, ERP
Use of own calculations, spreadsheets and other static calculation methods
Use of simulation and optimisation methods
There is a need for a quick response tool to evaluate alternatives and scenarios before strategic, tactical or operational decisions are made (see Figure 1). Optimisation and simulation modelling could be used to provide information for decision makers.
\n\t\t\tVisual analytics provides visual and interactive tools for analytical reasoning and decision making from data. The basic idea is to combine the strengths of automatic data analysis with the visual perception and analysis capabilities of the human user. It is especially focused on situations where the huge amount of data and the complexity of the problem make automatic reasoning impossible without human interaction. It combines different data sources containing complex and heterogeneous data of various types and qualities. (Järvinen et al. 2009).
\n\t\t\t\tVisual analytics is a new and active research field that has its origins in U.S. national security. It is a multi-disciplinary research area, combining information visualisation science, data mining, mathematical and statistical methods, data management, user interface techniques as well as human perception and cognition research. It can be applied in all areas where decisions need to be made on the basis of accumulated data. The manufacturing industry is one promising application area. All phases of the manufacturing process generate data, which is often stored in separate and heterogeneous data stores, and quick decision making on the basis of data is required to keep the production process effective.
\n\t\t\t\tHeterogeneous information systems (business, product and facility) as well as factory-floor software parallel to a simulation-based decision support system.
Manufacturing system operations planning is usually performed in a heterogeneous information system environment (see Figure 5). There are business-oriented systems like Enterprise Resource Planning (ERP) – or Manufacturing Resource Planning (MPRII) or Material Requirements Planning (MRP) – Customer Relationship Management (CRM), facility-related systems like Enterprise Asset Management (EAM) or Maintenance Management System (MMS) and Product Data Management systems (PDM). Systems potentially used on the factory floor include a Manufacturing Execution System (MES), job shop data acquisition systems, quality control system, individual machine control systems and so on. A dedicated decision support system for manufacturing operations planning does not replace those existing systems; they remain in place as parallel systems, serving as sources of information for decision making. Depending on the role of the decision support system user, he or she also has access to these other systems.
\n\t\t\t“Simulation is the imitation of the operation of the real-world process or system over time. Simulation involves the generation of an artificial history of the system and the observation of that artificial history to draw inferences concerning the operating characteristics of the real system that is represented”. (Banks et al. 1996)
\n\t\t\t\tManufacturing simulation focuses on modelling the behaviour of manufacturing organisations, processes and systems. Traditionally simulation tools have been used in system planning and design. Simulation models live as long as there is a need for strategic planning. Once the system has been implemented, the model loses its value and is set aside until other strategic decisions have to be made. Today, simulation models are used in all the different system levels and phases of the manufacturing system life cycle (see Figure 6). The more accurate the model, with detailed process elements, the more complex it is to build, and the more data is needed. The following steps are found: concept creation, layout planning, production simulation, software development and operator training (Heilala et al. 2001, \n\t\t\t\t\t\t2007\n\t\t\t\t\t). Naturally, there are a wide variety of simulation tools in the manufacturing domain.
\n\t\t\t\tManufacturing systems modelling and simulation has many hierarchical levels and development aims, and can be used in different life cycle phases.
The use of discrete event simulation (DES) can be enhanced to also cover production operations planning as a decision support tool, as suggested by Thomson (1993). Table 1 summarises the use of discrete event simulation in manufacturing life cycle phases. The design and analysis of the system concept provide input for strategic decisions. Production planning with simulation provides input for operational decisions.
\n\t\t\t\tDiscrete event simulation methods are feasible for analysis of all types of discrete manufacturing systems, from project shops to automated production and assembly lines, and even all the way to the supply chain. A review on simulation-based real-time decision making for manufacturing automation systems is presented by Yoon and Shen (2006). Kádár et al. (2006) present how to use discrete event simulation for supporting production planning and scheduling decisions. In general, the annual Winter Simulation conference (http://www.wintersim.org/) is a good source for finding ongoing research and development results.
\n\t\t\t\tSystem life-cycle phase | \n\t\t\t\t\t\t\tWhat and how | \n\t\t\t\t\t\t\tWhy | \n\t\t\t\t\t\t
Concept creation, layout planning of cells, lines and factories. | \n\t\t\t\t\t\t\t2D and 3D visualisation, communication, animation, easy and fast modelling are needed. | \n\t\t\t\t\t\t\tSelling and developing ideas and concepts. Fast elimination of those that are unsuitable. | \n\t\t\t\t\t\t
Production simulation, detailed development of the system, design optimisation. | \n\t\t\t\t\t\t\tAnalysis of control principles, routing, buffer sizes, capacity, utilisation, throughput time, bottlenecks, etc. Data analysis, reports, multiple runs, stochastic values. | \n\t\t\t\t\t\t\tInvestment insurance, strategic decision support and detailed evaluation of alternatives. Simulation model is an intelligent document of the system. | \n\t\t\t\t\t\t
Control software development, debugging and validation. | \n\t\t\t\t\t\t\tControl software debugging and validation against virtual system, emulation. Real-time integration with validated simulation model and control software. | \n\t\t\t\t\t\t\tDebugging and testing the control system, shortening the development time, faster system installation, off-line control system development. | \n\t\t\t\t\t\t
Training of operators, ramp-up and installation of system. | \n\t\t\t\t\t\t\tTraining with virtual model and control software. Emulation, integration of validated simulation model and control software. | \n\t\t\t\t\t\t\tExperience for operators, normal use and exceptions, faster ramp-up. | \n\t\t\t\t\t\t
Operational use, problem solving in exceptions, validation of production plans. | \n\t\t\t\t\t\t\tSimulation tools for production managers. Data integration, easy to use graphical user interface, fast analysis, embedded simulation. | \n\t\t\t\t\t\t\tDecision support for operations planning, short-term scheduling, operational and tactical capacity planning, order-book validation. | \n\t\t\t\t\t\t
Use of discrete event simulation in different manufacturing system life-cycle phases, based on Heilala et al. (2001, \n\t\t\t\t\t\t\t\t2007\n\t\t\t\t\t\t\t).
While some DES models are used for planning and design, other models are used in the day-to-day operational production planning of manufacturing facilities. These "as built"\' models provide manufacturers with the ability to evaluate the capacity of the system for new orders, unforeseen events such as equipment downtime, effects of missing materials, and changes in operations. Having built a simulation and calculations model, experiments are then performed by changing the input parameters and predicting the response. Experimentation is normally carried out by asking ’what-if’ questions and using the model to predict the likely outcome. Some operations models also provide schedules that manufacturers can use to run their facilities. Simulation can complement other planning and scheduling systems to validate plans and confirm schedules. Before taking a new order from a customer, a simulation model can show when the order will be completed and how taking the new order will affect other orders in the facility. Simulation can be used to support planners and schedulers and thereby boost production efficiency (Figure 1).
\n\t\t\t\tIt is important to recognise that normally simulation primarily serves as a decision support and evaluation tool for feasible scheduling and does not directly seek optimal solutions. Optimisation algorithms or scheduling rules can be embedded into the simulation model or the system could combine optimisation and simulation as presented by Appelqvist and Lehtonen (2005) and Vasudevan et al. (2008).
\n\t\t\t\tPotential uses of simulation-aided decision support for production planning are shown in Figure 7. In operations planning, a validated and tested simulation model is a must, as is having reliable data for analysis. The challenges of manufacturing system simulation and modelling are discussed later in the text.
\n\t\t\tPotential use of simulation-aided decision support for production planning.
Simulation-based scheduling and planning tools are actively being developed. Commercial solutions exist; some of the latest examples have been presented by Hindle and Duffin (2006) and Vasudevan et al. (2008). The semiconductor and process industries have been leading the way. Clear reasons for this include expensive equipment, the need to keep equipment utilisation high and customer service. In the mechanical industry, there are limited examples of the use of simulation or optimisation tools in operational planning, the finite scheduling of manufacturing, despite the availability of dedicated software packages like Preactor (www.preactor.com), Asprova (www.asprova.com), and others made by simulation engineering offices, like Simul8-Planner (www.simul8-planner.com) and Delfoi Planner (www.delfoi.com/web/en_GB/). Commercial simulation software can potentially be used as a development platform.
\n\t\t\t\tThe cheapest packages have fixed data structures and menus. This kind of Gantt chart scheduling software is targeted at users with simple production scheduling problems typical of small job shops. Open source softwares from a research institutes are available. Such software is usually targeted at simpler production scheduling problems or educational use. More information is available at the Production Scheduling Portal (www.productionscheduling.com).
\n\t\t\t\tThe more advanced, customised solutions are expensive and their costs are not limited to the price of the software. The costs of integrating simulation systems with other manufacturing applications are high; there is always a need to transfer and share data between the simulation and other manufacturing software applications. Custom-built proprietary interfaces are too costly, making it prohibitive for users to use simulation technology. Thus applications need to be customised extensively; due to the lack of standardisation, system integration is challenging. Naturally, if managers are using a simulation model to plan operations, the model must be precise enough and use accurate data.
\n\t\t\t\tSome of the benefits of implementing an operational simulation scheduling system include: less effort required to plan day-to-day scheduling, customer order due date conformance, synchronisation of the flow through the plant; minimisation of set-ups/changeovers, early warnings of potential problems, checks of critical resources and materials, and, of course, “what-if” scenario analysis for capacity planning.
\n\t\t\tAn operational decision support system has many potential users (Table 2), from the operator on the production line to the plant manager. Present Factory Information System (FIS) capability is geared towards supporting operators and engineers, not planners, financial analysts, and upper management. Manufacturers have begun the transition from passive data monitoring to converting data to information, and they have not attempted proactive, operational and strategic decision making.
\n\t\t\t\tDifferent users require, or are allowed access to, different types of information, or the same information is presented differently. Users should be given enough information to enable them to make the decisions necessary to optimise the performance of their job function. One of the challenges is to provide the appropriate granularity of information needed by each class of user.
\n\t\t\t\tOrganisational and operational level | \n\t\t\t\t\t\t\tUser | \n\t\t\t\t\t\t\tTime frame | \n\t\t\t\t\t\t\tData and information | \n\t\t\t\t\t\t\tDecision | \n\t\t\t\t\t\t
Manufacturing Cell/Line | \n\t\t\t\t\t\t\tSupervisor Process Engineer Production Planners | \n\t\t\t\t\t\t\tMinutes/Hours/ Shifts | \n\t\t\t\t\t\t\tProduction line data, e.g. process data, equipment utilisation, material availability | \n\t\t\t\t\t\t\tAssignment of order to each line/machine, scheduling of orders. | \n\t\t\t\t\t\t
Business Unit/Plant | \n\t\t\t\t\t\t\tPlant Manager Production Teams Customer service | \n\t\t\t\t\t\t\tShifts/Days/ Weeks | \n\t\t\t\t\t\t\tSummarised data from Cell/Line level e.g. production, subcontracting, materials | \n\t\t\t\t\t\t\tDetermination of an order list, workload, scheduling of order book and forecasts | \n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t | Upper Management | \n\t\t\t\t\t\t\tDays/Weeks/ Months | \n\t\t\t\t\t\t\tSummarised data from Business Unit/Plant level | \n\t\t\t\t\t\t\tMake or buy, production mix, budget planning, game plans | \n\t\t\t\t\t\t
Suppliers | \n\t\t\t\t\t\t\tOEMs Partners | \n\t\t\t\t\t\t\tDays/Weeks/ Months | \n\t\t\t\t\t\t\tSupply data such as production numbers, due dates. | \n\t\t\t\t\t\t\tProduction planning | \n\t\t\t\t\t\t
Decision and planning data at different organisational levels.
Manufacturing systems, processes and data are growing and becoming more complex. Manufacturing engineering and production management decisions involve the consideration of many interdependent factors and variables. These often complex, interdependent factors and variables are probably too many for the human mind to cope with at one time (McLean & Leong 2001a; 2001b). Simulation modelling and analysis could help. Discrete event/material flow/factory simulation is used commonly in the manufacturing system design phase to evaluate the concept and optimise system solutions, sometimes also for training operators or selling ideas to potential customers, using a "virtual factory" as shown in this chapter.
\n\t\t\t\tThe IMTI Modelling and Simulation for Affordable Manufacturing Roadmap (IMTI 2003) defines 75 top-level goals and 250 supporting requirements for research, development, and implementation of modelling and simulation technologies and capabilities. Subsequent processing has distilled these needs into four focused, high-level goals:
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\n\t\t\t\t\t\t
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\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
These challenges partially overlap. One other common challenge is input data collection and management as presented by Skoogh (2009). The following sections addresses these challenges and discusses selected public case studies carried out at VTT.
\n\t\tThe VTT solution concept presented here is a hybrid decision support system solution. The industrial cases presented in this chapter use complex multi-criteria models, i.e. discrete manufacturing system simulation, to provide decision support. The solutions use data from existing manufacturing information systems and parameters provided by decision makers to aid decision makers in analysing current and future production situations. Visualisation of the current and future factory-floor status is essential in decision making as well as interactive user-system communication for “what-if” scenario analysis. The system can be called a model-oriented or model-based decision support system (see Figure 1).
\n\t\t\tThe earlier development of some applied research projects has been discussed elsewhere (Heilala et al., 1999; 2001). Both then and now, similar aims have been set for development: to increase customer order delivery accuracy, capacity planning and synchronisation of manufacturing tasks in customer-driven manufacturing. The developed functional prototype tools increased the agility of the production network in fast-changing environments; performance was evaluated by users, but actual research into the benefits of using the systems was not carried out. Past industrial pilot cases were from the mechanical, heavy mechanical and electronic industries.
\n\t\t\t\tThe basic concept is still the same. Although similarities can be found in the user interface, each of the pilots is unique. The past generic system environment is shown in Figures 8 and 9. Integration into other enterprise applications, like ERP or MRP, was done using formatted ASCII text files or CSV files. ASCII text transfer is a robust traditional method. SQL query has also been used. The number of input and parameter files depended on the enterprise IT system structure. The parameter file could be created and updated using spreadsheets or a simple text editor. The user interface also incorporated tools for data management.
\n\t\t\t\tCurrent VTT system concept for manufacturing operations planning
The analysis run in these pilot applications was a batch process (Figure 9). The target was to create a daily work list, short-term scheduling, capacity planning, order book creation and validation, and “what-if” scenarios in general. The length of a simulation run ranged from a single shift to a few weeks, months, or even years of simulated production time. It is important to note that there is a human in the loop; the user accepts or modifies the solution provided by the system.
\n\t\t\t\tThe user interface consisted of graphics, bar and Gantt charts, and custom reports pointing out potential problem areas in production, such as resource overload, unnecessary waiting times or missing components and orders that would be late in the future. The status of work centres and customer orders could even be seen at the component level.
\n\t\t\t\tAnalysis workflow.
The graphical user interface (GUI) can have several windows. Scheduling changes could be done interactively, e.g. with a mouse and simple drag and drop. The first GUIs were based on MS Office tools, MS Excel and MS Project as reported by Heilala et al. (1999), but there were limitations. In later cases the user interfaces were programmed using Visual Basic and some OCX libraries (Heilala et al., 2001; 2007).
\n\t\t\t\tThe two first case studies, carried out in 1997-1999 (Heilala et al. 1999), a commercial simulation software Automod was used (www.automod.com). The run-time features were enhanced with C programming language algorithms. One of the main results was a generic and parametric model, which was automatically initialised and configured based on input data files.
\n\t\t\t\tAnalysis of the process flow is shown in Figure 9. Optionally, a simple 3D animation of the simulation could have been used, but since more computer capacity would have been required for this, it was normally not used in daily operations planning. Production managers were satisfied with bar and Gantt chart type visualisation. It is important to note that the user approved all the changes and he or she had control of the decision. The user could initiate an optional what-if analysis, such as of machine breakdowns, by editing the input files or using the user-interface functionality. Later case studies, carried out in 1999-2001 (Heilala et al. 2001), studied also the potential to do simulation calculations directly in the graphical user interface and to also add new features for analysis. In addition, those early cases included the order engineering phase, and partly subcontracting of selected critical components.
\n\t\t\tThe latest public case studies have been presented at the Winter Simulation conference by Heilala et al. (2007). The industrial partners in the pilot cases were Sandvik Mining and Construction Oy (www.sandvik.com), a producer of rock drilling equipment, single and multi-boom mining and tunnelling jumbos and long-hole production drill rigs, and Raute Corporation (www.raute.com), a supplier of a complete range of machinery, systems and technology for the production of plywood and veneer, including log handling, peeling, drying, veneer handling, plywood layup and pressing, panel handling and automation and control.
\n\t\t\t\tThe industrial pilots had different aims and development platforms. The heavy machinery case, Sandvik, which involves the customer-driven manufacturing of mining equipment, is purely an operational simulation case with tools for production managers. It is based on an embedded simulation platform, VTT’s proprietary GESIM (Generic Simulation). The Raute case involves plywood factory design and operational manufacturing simulation with simulation software based on the Visual Components 3DCreate®. Simulation development and modelling support the system sales process, equipment development, factory planning and later also operational planning at the real plywood factory.
\n\t\t\t\tIn the use of simulation methods for operations planning and scheduling, the key issue is getting the correct analysis data to make simulation as easy as possible. In both cases, generic development yielded improvements to the integration of manufacturing-related data from existing legacy systems, like ERP. Also, methods for automated model building were developed and advanced methods for simulation model management using a graphical user interface were studied. Simulation results must be presented in a visually effective way and some new ideas were evaluated in case studies. The development of tools and methods seeks to create easy-to-use, user-friendly solutions.
\n\t\t\tAn initial implementation of the Sandvik case study includes a graphical user interface (GUI) with simulation capabilities for production managers (Figure 10). Data integration is partially generic using custom-built proprietary interfaces. Simulation data is fed from the ERP as text files in CSV format; this is a robust integration into the ERP system. Current ERP systems usually have output to Excel or text files and thus the VTT system concept can be adapted to a new ERP system if needed. A simulation engine and calculations are embedded in the user interface and there is no 3D factory model. Simulation results are shown with a windows-style graphical user interface, bar and Gantt charts. The simulation system is parametric; adding resource data to the ERP also adds resources automatically to the simulation model when data is read into the system.
\n\t\t\t\tThe current GESIM-Sandvik solution has a wide range of functionalities. A wealth of information is readily available through pop-up windows with mouse interaction as well as functions for planning production operations. It is easy to re-schedule orders as well as forecasts, and to add and delete orders. The user interface shows the factory status: all orders are displayed in the upper window, while the workload on a selected resource is in the middle window, including estimates of the selected subcontractor’s workload and orders in the selected resource. Potential critical material shortages are displayed along with certain other warnings.
\n\t\t\t\tFinal assembly production is configured as flow line and products are moved to the next workplace at predefined time intervals. Since each order can have a different configuration, the workload on the workplaces varies. The solution here is to adjust the number of human operators in the workplaces. Simulation analysis shows the need for workers, or actually the work time needed in each process phase.
\n\t\t\t\tThere are several potential user groups in the company, but the principal planned users are production managers and production line foremen. Information flow is from the ERP system to the simulation. The evaluated and selected scenario must be entered manually into the ERP system, so the user is in control. The simulation tool helps in the planning of dynamic operations by enabling production managers to make better decisions.
\n\t\t\tUser interface, case Sandvik. Upper windows shows all orders and the critical path of the selected order, middle windows shows manual working hour in the selected resource and lower windows shows orders in the same selected resource or process phase.
The Raute case study — implementation of a simulation tool for plywood factory planning using Raute equipment models and later for scheduling plywood mill operations. An initial implementation is available, shown in Figure 11.
\n\t\t\t\tThe 3D factory simulation provides information on equipment and storage status. Some additional information can be shown using a Gantt chart type window. Depending on which windows are made active through the software user interface, other interactive menus will be opened.
\n\t\t\t\tThe first development focus was the creation of methods for simulation model building. Means of transferring simulation data from the database to the actual simulation model and controlling the simulation with an easy-to-use interface were developed. The automated model building functionality was developed with Visual Component software as well.
\n\t\t\t\tThe developed methods have many potential uses. For instance, they can serve as a tool for sales engineering or factory design. Later the methods can be used for the planning and optimisation of day-to-day factory operations. The current version evaluates the work schedules of the ERP systems and compares them with simulation run results. The user interface has many functions that are not presented here. The tool that was developed is an add-on for Visual Components 3DCreate®.
\n\t\t\t\tRaute case simulation, plywood factory with Raute equipments.
The tool concept created during the development projects can be adapted for different companies as described previously. The building of each application is still a project: that requires a resource commitment from both the developers and the end-user. Application set-up is simple within an enterprise if all its manufacturing information systems are the same; it is just a configuration task. This has been evaluated and tested in the past cases.
\n\t\t\tA typical simulation project is described in many simulation textbooks, for example Banks et al. (1996). Now the aim is to create an integrated or embedded simulation application for manufacturing personnel. This project is more challenging. The application needs data from various other manufacturing information systems. Furthermore, the human aspect – user interaction with the planned system – must be carefully developed.
\n\t\t\tBased on earlier development tasks at VTT, the guidelines from enterprise application integration (Linthicum, 2000), simulation project steps (Banks et al., 1996; Banks, 1998) and the user-centred design principle (Vilpola & Terho, 2008; ISO 13407 standard; Sears & Jacko, 2009), the following procedure for application building has been identified. These activities should be considered when approaching the development and implementation of operational simulation applications.
\n\t\t\tThe 10 steps in application building are (this is not a comprehensive list):
\n\t\t\tDefining the needs with the end-users
Defining the business processes and way of working
Specifying data and file structures, making sense of the data,
Collecting and creating data, interfacing
Specifying the graphical user interface, visualisation, user-centric design
Programming the graphical user interface
Implementing changes to the simulation and calculation model
Testing and validating the model and system
Integrating the application into the ERP or MRP system and other legacy systems
User training and documentation
The first steps are critical for successful implementation. These steps are required for requirements gathering. The input of the final end-user is necessary. Final end-user resources are also required in testing and system validation. This is an iterative and parallel development process.
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\n\t\t\t\t
Identifying the data
Cataloguing the data
Building the enterprise manufacturing metadata models
Definition of interfaces between systems
\n\t\t\t\t
\n\t\t\t\t
For the system sales process, the use of component-based simulation brings clear speed advantages to model building. But pre-engineered simulation components must be available. Model building centres on configuring a layout by selecting the right components to fulfil the process flow and setting the right parameters. In some VTT cases, Visual Components software is used as the development platform (www.visualcomponents.com). The selected software supports system modularity and reuse of existing simulation library elements. Similar development can be done with other object-oriented simulation software.
\n\t\t\t\tThe use of a simulation model can shorten the sales cycle of the production system — especially if the model can be created during the sales meeting and it creates additional information during the meeting, such as key performance indicators, capacity analyses and other decision-making parameters, for example system life cycle and other cost analyses. This is also the aim in one of the other industrial pilots of the recent development project, presented elsewhere Heilala et al. (2007b).
\n\t\t\tAutomated model building from ERP data is also being developed and tested in the industrial pilot cases with different simulation software. Depending on the 3D visualisation needs, manual input from a simulation engineer might be required. In general, the model and simulation load can be initiated based on information such as:
\n\t\t\t\twork orders (order book from ERP database), optional quotation book (from CRM or sales offices), production scheduling
product structure and routing, standard phase times
work centres and component factories, layout, equipment capability
stock items, buffers, material supply
factory calendar, holidays, absences, planned maintenance, etc.
equipment availability, efficiency
simulation parameters: depth of product structure, work order release rules
optional what-if analysis (machine breakdowns) and new orders, others.
The other generic development point has been simulation data management. Simulation data is exported in both pilot cases from ERP and potentially some other manufacturing information system as formatted ASCII text and CSV files. The user interface incorporates tools to map the data fields of different source files to the simulation database data fields. Means of controlling the simulation with an easy-to-use interface and presenting the simulation results were also developed.
\n\t\t\tThe use of standardised structured manufacturing data in a neutral format (like XML) could clearly increase interoperability between the manufacturing information system and the simulation, and also speed up modelling and problem solving cycles.
\n\t\t\tThe Core Manufacturing Simulation Data (CMSD) specification (SISO 2009) is intended to define a neutral format for the exchange of data between simulations and other manufacturing applications. The CMSD specification is being developed by NIST under the auspices of the Simulation Interoperability Standards Organisation (SISO). Over the last few years, several projects involving researchers from different industries have been undertaken where the draft CMSD specification (SISO 2006) is used to integrate manufacturing applications. Examples of these projects can be found in Kibira and McLean (2007), Johansson et al. (2007), McLean et al. (2007), Riddick and Lee (2008).
\n\t\t\tThe CMSD specification was developed to address interoperability issues related to information definition and exchange as it provides a neutral framework for modelling manufacturing information, with an emphasis on the information needed for manufacturing simulations. Information coding and representation problems increase the time and effort required to construct simulations and limit the application of simulation technology in manufacturing. Usually manufacturing simulation data is difficult to exchange between different simulation applications and other manufacturing applications. The Core Manufacturing Simulation Data specification is intended to be a neutral data format for addressing interoperability problems such as these. CMSD is defined as an information model using the Unified Modelling Language (UML) with a mapping to an exchangeable eXtensible Markup Language (XML) format.
\n\t\t\tThe CMSD information model describes essential entities in the manufacturing domain and relationships between those entities needed to create manufacturing-oriented simulations. This specification facilitates the exchange of information between manufacturing-oriented simulations and other manufacturing applications such as process planning, scheduling, inventory management, production management, and plant layout. Six UML packages define manufacturing information (SISO 2009). These packages are:
\n\t\t\tLayout
Part Information
Support
Resource Information
Production Operations
Production Planning.
\n\t\t\t\tLeong et al. (2006) give a detailed description of these packages. The draft specification (SISO 2009) provides the complete specification of CMSD. The formal balloting process for this specification is slated to begin in late 2009.
\n\t\t\tOther standardisation activities also might be useful in the future. For instance, ISA-95 (www.isa.org or www.isa-95.com) is focusing on MES/ERP integration. MIMOSA (ww.mimosa.org) is developing and encouraging the adoption of open information standards for operations and maintenance in manufacturing and facility environments. The MIMOSA open standard enables collaborative asset lifecycle management. The MTConnect Institute (www.mtconnect.org) is designing an open communication standard for interconnectability in the manufacturing arena. The MTConnect standard allows devices and systems to send out understandable information. Similarly, AutomationML (www.automationml.org) developed Automation Markup Language (AutomationML™) as an intermediate standardised format for the digital factory. All these standardisation efforts could help in getting real-time status information on manufacturing equipment.
\n\t\tSimulation analysis produces a great deal of numerical information consisting of tables, listings, and reports. It is difficult for a human decision maker to locate the relevant pieces of information. That is why normal operational users and production managers need tools for data mining. In addition, the simulation results have to be presented in a visually effective way to speed up and improve the way the results will be understood.
\n\t\t\tDifferent users require, or are allowed access to, different types of information or the same information is presented differently. For instance, a line supervisor and plant manager rely on different levels of data to base their business decisions — too little or too much data and its utility is diminished, if not lost. Time is an important factor in defining how much and what kind of data should be aggregated for the upper levels of the organisation; a manager cannot afford to be “swimming in data” when making a quick decision. (Heilala et al., 2001; 2007)
\n\t\t\tThe system gives, for example, a proposal for rescheduling production orders by showing late or early orders and overloaded components or resources. The user can change control and routing strategies and add resources to overloaded workplaces, either by adding more human operators, increasing working hours or using subcontracting. The user can reschedule orders, change batch sizes and so on with the visual interface and has the option of re-running the simulation to check the results.
\n\t\tThe development of the method is still ongoing at VTT, as shown in Figure 12.
\n\t\t\tOngoing development efforts at VTT 2009-2010, improvements to use near real-time information, simulation and user interface development
The following list describes the features of the VTT solution:
\n\t\t\tIndependent system, analysis is done offline from the ERP/MRP database
Batch process, no real-time integration to the ERP or MRP system, new iterations will use near real time factory status data
Traditional information transfer, earlier ASCII text, CSV files or SQL query; XML-based methods are now also being studied
Sensitive to quality of data, garbage in – garbage out, in the manner of all simulation and modelling
Deterministic simulation model for speed, using standard operation times, no stochastic values used
Visualisation of the order book, resource status, material availability
Window to future events with given input, scenario, evaluation of alternatives, proactive planning
Generic manufacturing system model, model updates and reconfiguration based on database information (some limitations)
Decisions are made by the user
The VTT solution presented here is not a real-time solution, as there is some data latency. Data latency is the characteristic of the data that defines how current the information needs to be (Linthicum, 2000).
\n\t\t\t\tReal time: data is current, up-to-the second.
Near time: data refers to information that is updated in set intervals rather than instantaneously.
One time: data is typically updated only once or very rarely.
Some of the input files are “one time”: only the modifications to the parameters are updated. Some other input files are “near time”: analysis can either be started by the user or is performed automatically at selected intervals. The latest version seeks to use the following near real-time data from other manufacturing information systems: maintenance management data, machine utilisation data and real-time work flow management data. In some earlier iterations, reliable data was several days old, and the current situation was simulated.
\n\t\t\tThe simulation and calculation model used in the cases could either have capacity constraints or unlimited capacity depending on the objectives of the user. In the first case, capacity constraints, the analysis shows when the order will be ready and how late it will be; it can also pinpoint the reason for late completion, such as a shortage of material, overload in manufacturing resources, and so on. In the latter case, unlimited capacity, the analysis shows the amount of resources needed in order to keep the customer promise, and the managers have the option to add, for example, human operators to critical manufacturing phases. Typically manual labour -intensive final assembly can be analysed with unlimited capacity if it is easy to add human operators when and where necessary. The model also checks the critical materials, i.e. stock values and ordered components, and indicates whether materials might run out at a certain time in the future (see also Figure 7). Scheduling control strategies can be embedded directly into the simulation model or can be kept as a separate file, enabling users to adjust the parameters as necessary.
\n\t\t\tThe authors have developed several simulation-based decision support systems (DSS) for customer-driven manufacturing. Selected cases are presented here: DSS for sales engineers (Raute) and operations planning (Sandvik and Raute). Both presented cases use complex multi-criteria models to provide decision support. The solutions use data and parameters provided by decision makers to help analyse future production situations.
\n\t\t\tAn operational decision support system has many potential users, from the operator on the production line to the plant manager and even upper management. Present Factory Information System (FIS) capability is geared towards supporting operators and engineers, not planners, financial analysts, and upper management. ERP or MRP systems have other limitations; they are usually based on static resource models with unlimited capacity. At present, manufacturing scenarios cannot be studied efficiently with the ERP system. Manufacturers have begun the transition from passive data monitoring to converting data to information, and must seek to engage in proactive, operational and strategic decision making in the future.
\n\t\t\tThe developed tool is useful in customer-driven manufacturing because it adds features for production planners and capacity managers that were not provided by standard tools in the past. By integrating discrete event simulation and traditional production planning methods, it is possible to forecast the required workloads with given input values. The simulation model and the developed graphical user interface make it possible to visualise the occurrence of potential bottlenecks or other production problems and to take corrective actions. The load data for simulation, indicating the product, its parameters as well as required quantities and delivery dates, will be obtained from marketing offices and ERP systems, so both orders and quotations can be used. Simulation gives the users a window to the future and information for decision making. It becomes possible to adjust work queues and orders, and to achieve a balanced rate of resource utilisation. Delivery days can be confirmed on the basis of the simulation model. Overload situations and unnecessary waiting time can be eliminated. The use of the tool is not limited only to operational planning; it is useful for strategic planning as well. The effects of additional equipment can be analysed.
\n\t\t\tMany other similar tools are available. One limiting factor for the wider use of the technology is the cost of data integration, the integration of the simulation model and other manufacturing information systems; in other words, the customisation cost is high. There is no commonly accepted data model standard. Neutral standardised interfaces are needed and efforts are ongoing to aid the integration and development of reusable simulation models and objects. These interfaces would make modelling easier and reduce the costs associated with both model construction and data exchange between simulations and other manufacturing software applications. This would make simulation technology more affordable and accessible to a wide range of industrial users. The authors used ASCII text files in the presented case studies, but perhaps in the future XML will provide a better solution.
\n\t\t\tThe developed simulation tools can be adapted for new industrial fields and implemented for other enterprises. The developers must have a deep understanding of the processes of the field in question in order to be able to model the specific features of the industry. Naturally, modifications to the user interface and data interface are required. Both the end-user and system developer must commit development resources to the implementation project.
\n\t\t\tSimulation software has evolved and most of the current software is object oriented with a graphical windows-style user interface. At the same time, however, the complexity of manufacturing systems and products has increased. There are development needs in manufacturing system modelling and simulation: e.g. integration of different simulation and modelling methods – use of multi-disciplinary simulation with different abstraction levels. A simulation model and a manufacturing system life cycle should be combined, and the model should be a virtual, concurrently evolving digital image of the real system. Thus there is a need for real-time data coupling from the factory floor.
\n\t\t\tAnother future aim could be hybrid methods — simulation, optimisation and other manufacturing information systems in an integrated application. These could be used by non-simulation experts, even online and in real-time on the factory floor (plug and simulate), enabling science-based system management.
\n\t\t\tFuture development includes evaluation of the use of new optimisation parameters, such as energy consumption and other environmental aspects. The development of using environmental aspects in the system design phase has been presented by Heilala et al. (2008), Lind et al. (2009). The next step would be to use these parameters for production scheduling decisions as well.
\n\t\tThe chapter is a summary of following national public research projects: “Integrated dynamic simulation model of enterprise for planning of operations”, (1997-1999); “Integrated dynamic customer driven production network management using operative simulation” (2000-2001) and “Integrated dynamic electronic production and suppliers control and planning of resources” (2000-2001). Development work was later carried out in the projects “Modelling and simulation of manufacturing systems for value networks” (2005-2007) and “Optimisation of autonomous production cell - real time production intelligence”, (2009-2010). The industrial partners, VTT and TEKES (the Finnish Funding Agency for Technology and Innovation) have funded the work carried out by VTT.
\n\t\tAbiotic stress is an external environmental factor that influences plant growth stages. It includes a fluctuation in temperature ranging from chilling to heat stress, deposition of heavy metals in soil due to anthropogenic activities also results in heavy metal stress/toxicity. Limited availability of water for a shorter or longer period causes drought stress [1]. Most importantly and thoroughly discussed is the salt stress that arises due to deposition of higher salt contents in the soil layers due to poor application of irrigation water, higher evaporation that also deposits salt in the upper surface layer of the soil [2]. Currently, climate change is also stimulating several abiotic stresses on a yearly basis and the salinity problem is one of them. Globally, the number of salt-affected soils is increasing and approximately 20% of the agricultural land has been affected [3].
Salt stress also causes secondary stresses such as osmotic, water, ionic, and oxidative stresses. Osmotic stress is formed as soil salinity decreases the soil and leaf water potential, that disrupts the water relation of plants and decreases the turgor pressure of plants [4]. Plant roots serve as a medium of nutrient uptake, but the excessive salt solution in the vicinity of the roots forces its uptake that causes ionic toxicity in plants. Additionally, plant roots are unable to extract/absorb water that also further aggravates plants growth by acclimatizing its water stress. Plants start their journey from seed germination to seedling establishment, plant growth, and fruiting, however higher salt contents in the soil cause poor germination and weakened morphological growth leading to declined yield [5].
Salt stress also disrupts the physiological functioning of the plants, such as the closure of stomata, reduction in gaseous exchange, damage to photosynthetic machinery, decrease in chlorophyll contents, and distortion of PSII system [6, 7]. Salt stress also disrupts the biochemical functioning of the plants with the excessive production of reactive oxygen species (ROS) resulting in oxidative stress [8]. The ROS is favorable at a lower concentration that is crucial for cellular signaling processes for the induction of positive response in antioxidant defense likewise biological processes to help improve stress adaptation mechanisms [9]. However, higher ROS causes oxidative stress, and plants have the inherent ability to alleviate ROS species with the upregulation of genes that synthesize antioxidant enzymes [10]. Plants can tolerate salt stresses by maintaining antioxidant enzyme activity or increase their levels to cope with oxidative stress caused due to environmental adversities in various plant species [11]. Abiotic stress causes gene expression changes in plants and a comparison of these changes may provide information on adaptation and stress tolerance/sensitivity [12].
Transcription factors are involved in several biological processes in plants to regulate stress tolerance. Transgenic approaches have extensively used transcription factors that function in salt stress signaling pathways for the genetic engineering crops to confer stress tolerance. Most used transcription factors include ABA-binding factor (ABF), basic leucine zipper (bZIP), dehydration responsive element binding (DREB), myeloblastosis (MYB), NAC, and WRKY due to their significance in the signaling against salt stress [13]. Their specificity depends upon homodimerization, heterodimerization, and modifications at post transcription, post translation by small RNA (miRNA). Additionally, modification in histone modification and DNA methylation are involved to perform the main role for regulating gene expression in response to salt stress. The transcription factors bind to cis-acting elements in promoter regions to regulate gene expression. Therefore, they exhibited potential for controlling the expression of target genes, as some transcription factors are early stress-responsive genes [13, 14].
Currently with the introduction of novel genome editing techniques also assisted in developing stress-resilient genotypes. Generally, nowadays clustered regularly interspaced short palindromic repeats (CRISPR) is the most used genome editing technique due to simplicity and ease of availability. It is believed that unraveling of molecular mechanisms and genome editing approaches are the best options to pave the path to understand and develop stress tolerant genotypes to cope with future climate and ensure food security [15].
Roots provide anchorage, access to soil water, and essential nutrients required throughout the growth stages. Its morphological characteristics play an important role in the growth and production of plants [16]. During stress, the plant roots are the first organ that senses adverse conditions such as excessive salt in the soil. The study of the root system is of great interest as the structure and distribution of roots assist in higher water uptake. It also maintains the productivity of plants under salt stress conditions [17]. Salt stress interrupts the normal growth of the plants as excessive salt accumulation in the vicinity of roots and its uptake cause a toxic environment for plants. The typical symptoms of morphological growth of plant include retardation of vegetative growth, increase in plant development, senescence sometimes resulting in death [8]. The inhibited growth is the first noticeable symptom of salt stress that might results by alteration of cell division due to salinity shock. Other obvious symptoms of sodium accumulation in plants are necrosis of older leaves, it starts from the tip leading towards the leaf base. Therefore, it also causes early senescence of leaves resulting in poor plant biomass and yield. We also observed that higher salt contents resulted in a decreased number of leaves, plant height, and reduction in bulb yield of onion [6, 18]. Plant growth reduction with the acclimatization to salt stress is due to disruption of normal physio-biochemical in plants with the development of secondary stresses that are discussed below.
Salt stress disrupts the physiological functioning of the plant, as the first response of the plant is to limit gaseous exchange with the closure of stomata. It also helps in reducing the water loss of the plant. Higher salt accumulation along with stomatal closure limits CO2 intake that disturbs the photosynthesis of the plants. Likewise, photosynthesis of the plant decreases that ultimately affects vegetative growth and harvest yield [19]. It also aggravates ionic toxicity and osmotic stress to the plants. It is reported that abscisic acid (ABA) results in stomatal closure. The ABA is the main chemical compound that is produced in the roots in response to stress. It sends signals for the closure of stomata. It is directly linked to the rate of photosynthesis, therefore, damage to photosynthetic machinery and pigments [20]. Additionally, the plant also accumulates sucrose that changes electron transport. Increased salt contents in photosynthetic tissues also cause shrinkage of the thylakoid membrane. There is another perspective that decreased stomatal conductance is beneficial for the plant as it helps in limiting the entry of toxic ions via roots. It was corroborated by a couple of studies that decreased stomatal conductance resulted in a reduction of the uptake of ions to the transpiration stream [21]. Plants uptake higher Na+ contents from the soil under salt stress that decreases the uptake of other essential nutrients required by plants for their functioning. It causes an ionic imbalance in a plant that replaces K+ loading by Na+ to the chloroplast resulting in damaged photosystem II. It is the protein complex that functions in the catalyzation of light-induced water oxidation to the evolution of oxygen. Salt stress decreases the activity of PSII that decreases the quantum yield of PSII. It has been reported that NaCl inhibited the photochemical efficiency of PSII. It is sensitive to Na+ toxicity and directly reduces the photosynthesis process of the plant [7]. Osmotic stress is regarded as the deficiency of water in plant tissues due to excessive accumulation of salts. It is caused due to the inability of plant roots to absorb water. Higher Na+ also decreases the turgor potential of the plant [22]. Resultantly the supply of water to the leaf decreases that causes lower leaf development. Decreased number of leaves or senescence directly reduces the photosynthetic rate and damage to chlorophyll contents. Salt-sensitive genotypes that are unable to cope with stress suffer from dehydration caused by a disturbance in turgor pressure resulting in the death of plant tissues [23].
Salt stress directly causes ionic imbalances and with the severity of the stress to ionic toxicity. Moreover, it also triggers oxidative stress with the higher production ROS. The toxic influence of higher ROS accumulation causes increased lipid peroxidation, membrane damage, in addition DNA and protein damage [24]. The ROS are mostly produced in chloroplast and mitochondria that include singlet oxygen (1O2), superoxide radical (O2•−), hydroxyl radical (•OH), and hydrogen peroxide (H2O2). It includes superoxide dismutase that works as a first in the antioxidant system by catalyzing the dismutation of superoxide radical (O2•−) to H2O2 and O2 in the cytosol. Ascorbate peroxidase is the main player in detoxifying hydrogen peroxide in plant chloroplast, mitochondria, cytosol, and peroxisomes during stress conditions. It utilizes ascorbic acid as an electron donor for the reduction of H2O2 to H2O. Catalase also alleviates oxidative damages by converting H2O2 to H2O [25].
Secondary metabolites such as tocopherol play role in the stabilization of the membrane integrity. It also works as a signaling molecule in response to stress between cells [26]. Ascorbic acid is an important antioxidant that is found abundantly in the apoplast and cellular organelles. It scavenges 1O2, O2•−, and •OH for plant adaptation against salinity. Carotenoids are localized in the chloroplast that is reported to help plants in light reception to continue the process of photosynthesis, furthermore, they are also known as a protective compound for scavenging ROS species [27]. Putrescine supplementation is beneficial to restrain the production of ROS, as it speeds up the antioxygenic enzymes that ultimately help in protecting the chloroplast membrane [28]. In one of the study, putrescines are reported to enhance the level of carotenoids and glutathione in response to salt stress [29].
Several studies have reported the higher accumulation of ROS is a response to stress leading to cellular damages [7]. Additionally, it was also observed that higher production ROS due to salt stress caused decreased crop production. Therefore, it is essential to control the regulation of ROS to protect plant tissues from cellular damage caused by oxidative burst. Moreover, C4 plants have been reported to show higher resistance to salinity compared with C3 plants. As they have a better capability of preserving photosynthetic mechanisms against oxidative stress [30]. Salt stress influence on plant oxidative stress is shown in Figure 1.
Plant responses to salinity stress. Salinity favors the higher uptake of Na+ and lower uptake of K+ that causes ionic homeostasis leading oxidative burst and reduced growth and yield.
Several genes have been identified that encode antioxidant enzymes SOD, CAT, APX, and glutathione reductases (GRs), that are involved to scavenge ROS in plants. These genes are described as T genes as they contribute to stress tolerance [9]. Contrarily S genes have been reported that result in excessive ROS production. They are responsible for higher oxidative stress, increased programmed cell death, decreased antioxidant activity. Other gene group that causes disturbances in hormonal concentration, or ionic distribution have also been reported. Plant molecular breeders have utilized these identified T genes to incorporate into plants to confer salt stress tolerance. The list of some antioxidant genes is given in Table 1.
Crops | Gene | Function | Reference |
---|---|---|---|
Tobacco | CuZnSOD, APX | Reduced oxidative stress | [31] |
Wheat | P5CS | Higher proline accumulation | [32] |
Onion | Cat | Improved catalase activity | [7] |
Rice | OsGR2 | Alleviated oxidative stress | [33] |
Tomato | SOD | Decreased ROS production | [34] |
Maize | APX, SOD, CAT, POD | Higher antioxidant enzymatic activities to cope ROS | [35] |
Genes responsible for the alleviation of oxidative stress in crops.
Plant response to salinity stress is a complicated process that includes a various numbers of genes to finally activate physiological and biochemical mechanisms. The study of these genes provided a new horizon to identify their functions to cope with stress. These genes initiate a transcriptional response in plants with a set of several genes and their transcription also varies with the severity and duration of the stress. As they are categorized as early responsive genes that protect the plant by stimulating genes for free radical scavengers, detoxification enzymes, osmoprotectants, etc. The second ones are transcription factors, protein kinases, whereas the third group includes ion transporters and aquaporins [36].
Plants being sessile must suffer from salt stress and suffer from several secondary stresses caused by Na+. They undergo several morpho-physiological and biochemical changes to adapt/cope with stress that has been thoroughly studied. However, until now, the identification of Na+ sensors and perception by plants is still ambiguous. Under salt stress conditions, cellular organelles, and compartments such as the nucleus, chloroplast, peroxisome, plasma membrane, apoplast, and cell wall play crucial roles. Regardless of all the recent progress in unraveling complex stress mechanisms, there is still needed to find out how stress signals are generated, integrated, and coordinated in/from different organelles. Furthermore, scientists have identified specific genes, genomic regions, proteins, and metabolites against salt stress. The high-throughput transcriptomics and proteomics are potent functional genomic that can elucidate cellular networks for the perception of salt stress. Higher Na+ causes a higher accumulation of ROS in plant tissues that disturbs the K+ and Ca2+ homeostasis [37, 38]. These stress constraints theoretically may be sensed either by cytosolic or membrane-bound sensors that later translated into physio-biochemical and genetic modifications for the optimization of plant growth. There is also a high probability that a couple of sensory mechanisms might operate in the same cell, and at same time translating information related to the severity of stress. Therefore, it remained a great challenge to understand the mechanisms of signaling. Higher salt concentration disturbs the ionic homeostasis causing ionic stress. It is a general perspective that it triggers the elevated Ca2+ levels in the cytosol within seconds after exposure to salinity. It is further aided due to the activation of slow-activating vacuolar/two-pore channel 1 that results in the release of vacuolar Ca2+. Therefore, the identification of proteins involved in the quick influx of Ca2+ is efficient for the discovery of salinity sensors.
Additionally, non-selective cation channels include a diverse group of ionic channels having the capability to discriminate several essential nutrient and toxic ions to plant under salinity conditions [40]. Increased cytosolic Ca2+ is largely accumulated in the cortex and endodermis of the root. Its higher influx also stimulates Ca2+/calmodulin (CaM)-dependent kinases, that trigger plasma-membrane H+ ATPase [41]. Higher ROS burst is also due to elevated levels of cytosolic Ca2+. Therefore, both higher ROS and Ca2+ regulate the release of abscisic acid resulting in the initiation of transcriptional responses [42].
Stress stimulus perception needs cell-surface harboring sensors or receptors to understand different stresses for the transduction of signal via signaling pathways. The main signaling pathways include receptor-like protein kinases (RLK), mitogen-activated protein kinase (MAPK) that are known as molecular switches for upstream signaling for the determination of the fate of plants in response to environmental stresses [43]. Thus, to understand how plants recognize high concentrations of salt and ultimately adapt themselves to salt stress is essential. The MAPK signaling cascade is the main pathway. It connects the external environment to the endogenic cellular activities of the plant. It is conserved in Arabidopsis which exhibited 20 MAPKs [44]. Their activation targets specific substrates i.e., transcription factors and other kinases. It confers salt stress tolerance by regulating salt-related genes for the homeostasis of oxidative burst and likewise osmotic stress [45]. With the exposure to salt stress, activated MAPK cascades initiated the varied transcriptional response of salt-related genes [46]. It suggested the link between salt sensors and target genes. Transcriptome analysis of Arabidopsis revealed that 152 genes changed their expression with the over-expression of MAPK. Modified genes can be clustered into different types. Some genes are regarded as stress marker genes, and others as ethylene, jasmonic acid, and auxin signaling [47, 48].
Transcription factor is a protein that attaches to the DNA-regulatory sequences usually found in the 5′-upstream region of target genes to initiate the rate of transcription of the gene. They help turn “on” or “off” the specific genes with the binding to the neighboring DNA. This results in increasing or decreasing the transcription of the gene, synthesis of protein, and ultimately modifies cellular functioning against salt stress. Additionally, they also perform a function to control cellular processes such as cell cycle mechanisms, intercellular regulation mechanisms, reproduction, growth [49]. Their most important salt stress responses make valuable for the characterization of their functions [50, 51]. Some transcription factors are highly conserved in plants that modify gene expression to confer stress tolerance against salt [52]. The main transcription factors that respond to abiotic stresses are bZIP, NAC, WRKY, AP2, MYB, DREB, and bHLH. They follow ABA-dependent and ABA-independent signal pathways. These pathways are highly involved in controlling gene expression [53]. They are essential for the association of signaling pathways for their involvement in gene expression, thereby it signifies the importance of these factors in the plant genome. As arabidopsis genome sequence revealed 1500 transcription factors [54]. The transcription factors play a crucial role in plant adaptation against different environments [55]. One transcription factor is responsible for controlling the expression of numerous genes. In this way, the engineering of these factors further highlighted their importance to upregulate or downregulate the gene expression for plant adaptation to salt stress. The union of these factors developed a transcription unit called regulon (a group of numerous genes that turns on/off as a unit). Very few regulons have been reported in plants in response to abiotic stresses. One of them is DREB regulon and its overexpression exhibited tolerance against major abiotic stresses such as cold, drought, and salt stress [56]. The wheat cultivars exposed to long-term salinity and bZIP gene expression was noticed significantly upregulated that conferred salinity tolerance in sensitive cultivars, contrarily its expression was lower in tolerant cultivars [57]. The other transcription factor NAC genes were overexpressed. Its higher expression alleviated the harmful effects and rendered salt stress tolerance [58]. Another study also reported that NAC5 gene showed upregulated gene expression in response to salt stress. Moreover, it might also regulate the production and aggregation of proline, sugar, LEA proteins to mitigate oxidative stress in plants [59]. Rice is a monocot model plant therefore it has been explored to unravel information about transcription factors. In rice SALT-RESPONSIVE ERF1 (SERF1), the gene showed root-specific stimulation after being acclimatized to salinity. The SERF1 gene is responsive against H2O2, which means that it has the potential to minimize ROS burden in plants [60].
Salt stress disrupts the ionic homeostasis in plant cells and causes ionic stress. The increased concentration of Na+ and Cl− ions disturbs the K+/Na+ ratio with the formation of a toxic environment for plant cells. It is mainly caused due to favoring higher uptake of Na+ through the same pathway that uptakes K+. It is also reported that it is difficult for transporter proteins. Another assumption is that it is hard for plant transporter protein to differentiate between Na+ and K+ due to similarity. Additionally, both ions are competitors of each other to occupy binding sites. Therefore, the plant uptakes higher Na+ ions and results in Na+ toxicity. The Na+ influx in cytosol increases making plants difficult to thrive due to salt stress. Higher Na+ efflux into the cytoplasm results in depolarization of the membrane potential, which also activates outward rectifier channels (K+) i.e. guard cell outward rectifying K+ channel (GORK) for the extrusion of K+ [61].
Conversely, plants have adopted a mechanism to minimize the influx of Na+ ions to avoid depolarization of membrane by retaining a negative potential to enhance retention of intracellular K+ [62]. The antiporters Na+/H+ helps in vacuolar Na+ compartmentation and extrusion from the cell. It is considered as a vital process for the detoxification of Na+ from the cytosol and helps in osmotic homeostasis to confer salt stress tolerance. In salt stress, several selective pumps activate to favor K+ uptake instead of Na+. They use high and low-affinity potassium transporters for the uptake of K+. The transporters include Na+/H+ exchangers (NHX), salt overly sensitive 1 (SOS1) antiporter are crucial to decrease salt stress [62, 63].
High-affinity potassium transporter (HKT) protein was reported to be the first selective transporter that performs the selective role for K+ uptake instead of Na+ [64]. It plays an important role in the exclusion of Na+ and maintains K+ homeostasis. The transporter HKT2;1 has been reported for conferring tolerance against salt stress. The NHX that are localized in the tonoplast also performs a key role to restrict the entry of Na+ by promoting the outer movement of Na+ to the vacuole. The SOS1 functions as an exchanger in the plasma membrane. Its overexpression conferred salt tolerance [65].
In the field of functional genomics in plants epigenetics has gained much attention due to its potential for the adaptation of plants against stress. Salt stress significantly reduces the vegetative growth and yield of the crops. In past conventional breeding, approaches helped a lot for the selection and adaptation of plants but they are time-consuming [66]. Currently, new genetic approaches such as epigenetics that modifies plant genome without changing the sequence of DNA such as histone modification, methylation and demethylation of DNA, and gene imprinting are helping hand for the development of stress-resilient genotypes [67]. It also refers to the heritable variation in the regulation of genes leading to DNA modifications and protein. These modifications are reversible that can alter the phenotype of the plant. As methylation of cytosine is a conserved mechanism of epigenetics that is involved in several biological processes e.g., the proliferation of transposons, and regulation of gene expression in response to salt stress. Generally, it inactivates the genes whereas demethylation is responsible for the activation of the gene. It was further corroborated by genome-wide mapping that methylated genes were 8% that showed activation, whereas methylation of the transcribed region exhibited 31% expressed genes. Salt stress influence on cytosine methylation has been reported in many important crops. It is a conserved epigenetic mechanism that plays a crucial role in several biological processes in plants. It includes transposon proliferation, genomic imprinting, and gene expressional changes. Generally, it is related with the inactivation/suppression of genes expression, contrarily demethylation causes activation of genes [68, 69]. A study reported that salinity-induced methylation resulted in down-regulation of negative regulator, whereas it upregulated positive regulated [70]. The H3K9ac and H3K4me3 positively regulate gene expression and H3K9 methylation is reported as a repressive chromatin marker [71].
Change, any alteration, or target mutagenesis of the genome is known as genome editing. With the advent of this modern technology, it allows the introduction of specific changes with more precision at specific sites. It utilizes engineered nucleases that cleave the sequence of target DNA strand breaks, that are repaired by either homologous recombination or non-homologous end-joining. The customized modifications of DNA that include insertions, deletions, can be obtained via DNA repair mechanisms. Until now four different genome engineering techniques have been used in plants. These include meganucleases, zinc finger nucleases, transcription activator-like effector nucleases, and the most recently introduced is CRISPR/Cas RNA-guided nucleases [72]. CRISPR is a new versatile tool for genome editing derived from a bacterial system. This eminent technology showed promising results to edit genomes of different plants, resulting in improved plant biotechnology research. Currently is being employed for the development of new varieties with improved traits against salt stress shown in Figure 2 [73].
Salt stress and role of genome editing for the development of salt tolerant plants.
This technology has the ability of multiplexing that can co-target multiple loci, therefore it has the great potential to knockout the complete cassette of non-desirable genes that halts plant growth in response to salt stress. It can be used to disrupt the functions of a negative regulators, such as RMC transcription factor negatively regulates in response to salt stress [74]. Several genes have not been explored that are responsible for the negative regulation of salt stress. The RING finger protein 1 is a ubiquitin ligase E3 that is a negative regulator that enhances the production of H2O2 and suppresses antioxidant enzyme activities. However, the knockdown of this negative regulator resulted in disruption of H2O2 synthesis and positively regulated antioxidant enzymatic activities [75]. Disruption of the functions of genes by CRISPR to confer salt stress tolerance is given in Table 2.
Crops | Gene | Function | Reference |
---|---|---|---|
Rice | OsDST | Decreased stomatal density and tolerance to osmotic stress | [76] |
Tomato | HyPRP1 | Negative regulator of salt stress | [73] |
Rice | OTS1 | Regulator for salt stress response | [77] |
Maize | HKT1 | Potassium transporter | [78] |
Tomato | CLV3 | Regulates shoot development | [79] |
Tomato | Tolerance to osmotic stress | [80] | |
Wheat | TaERF4 | Transcription repressor of ABA | [81] |
Genes knockdown by CRISPR/Cas for salinity tolerance.
The CRISPR-based epigenome editing helps in protecting the plants from the harmful effects of salt stress [82]. The CRISPR/Cas9 protein has been used as a dCas9 is attached to the modifier of epigenetics for the alteration of gene expression [83].
Plant tolerance to salt stress involves several complex molecular mechanisms to respond for better morphological growth and maintain physiological functioning. Extensive research has been conducted to elucidate the physio-biochemical responses to control Na+ uptake, its transport, and cellular homeostasis by minimizing oxidative stress. In this regard plant sensors and signaling played a crucial role in the adaptation of plants. Additionally, regulation of gene expression of the positive regulators also assists in salt stress tolerance. Conventional breeding techniques have been used for developing new varieties but that is time consuming however with the advent of genome editing as a tool for plant breeder, tolerant plants can be developed within a less period by disrupting the function of negative regulators or improving traits for salinity tolerance. Additionally, in the future to cope with the negative influence of harsh salt stress problems plant epigenetics can be explored for a better understanding of plant salt stress responses. It can also be potentially used for the regulation of gene expression that can confer salt stress tolerance.
The authors declare no conflict of interest.
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This problematic is particularly relevant with medical imaging data, where linear techniques are frequently unsuitable for capturing variations in anatomical structures. In many cases, there is enough structure in the data (CT, MRI, ultrasound) so a lower dimensional object can describe the degrees of freedom, such as in a manifold structure. Still, complex, multivariate distributions tend to demonstrate highly variable structural topologies that are impossible to capture with a single manifold learning algorithm. This chapter will present recent techniques developed in manifold theory for medical imaging analysis, to allow for statistical organ shape modeling, image segmentation and registration from the concept of navigation of manifolds, classification, as well as disease prediction models based on discriminant manifolds. 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Manifold regularization is one of the most popular works that exploits the geometry of the probability distribution that generates the data and incorporates them as regularization terms. There are many representative works of manifold regularization including Laplacian regularization (LapR), Hessian regularization (HesR) and p-Laplacian regularization (pLapR). Based on the manifold regularization framework, many extensions and applications have been reported. In the chapter, we review the LapR and HesR, and we introduce an approximation algorithm of graph p-Laplacian. 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Based on the assumption that informative and discriminative representation of the data lies on a low-dimensional smooth manifold which implicitly embedded in the original high-dimensional space, manifold learning aims to learn the low-dimensional representation following some geometrical protocols, such as preserving piecewise local structure of the original data. Manifold learning also plays an important role in the applications of computer vision, i.e., face image analysis. According to the observations that many face-related research is benefitted by the head pose estimation, and the continuous variation of head pose can be modelled and interpreted as a low-dimensional smooth manifold, we will focus on the head pose estimation via manifold learning in this chapter. Generally, head pose is hard to directly explore from the high-dimensional space interpreted as face images, which is, however, can be efficiently represented in low-dimensional manifold. 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According to the behaviour of the tangent bundle of a sub-manifold, with respect to the action of almost Riemannian product structure of the ambient manifolds, we have three typical classes of sub-manifolds such as invariant sub-manifolds, anti-invariant sub-manifolds and semi-invariant sub-manifolds. 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The definition of Clifford algebra implies geometric concepts such as vector, length, angle, area, and volume and unifies the calculus of scalar, spinor, vector, and tensor, so that it is able to naturally describe all variables and calculus in geometry and physics. Clifford algebra unifies and generalizes real number, complex, quaternion, and vector algebra and converts complicated relations and operations into intuitive matrix algebra independent of coordinate systems. By localizing the basis or frame of space-time and introducing differential and connection operators, Clifford algebra also contains Riemann geometry. Clifford algebra provides a unified, standard, elegant, and open language and tools for numerous complicated mathematical and physical theories. Clifford algebra calculus is an arithmetic-like operation that can be well understood by everyone. 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So, Clifford algebra can be expected to complete a new big synthesis of scientific knowledge.",book:{id:"8760",slug:"structure-topology-and-symplectic-geometry",title:"Structure Topology and Symplectic Geometry",fullTitle:"Structure Topology and Symplectic Geometry"},signatures:"Ying-Qiu Gu",authors:[{id:"314607",title:"Dr.",name:"Ying-Qiu",middleName:null,surname:"Gu",slug:"ying-qiu-gu",fullName:"Ying-Qiu Gu"}]},{id:"52596",title:"Symplectic Manifolds: Gromov-Witten Invariants on Symplectic and Almost Contact Metric Manifolds",slug:"symplectic-manifolds-gromov-witten-invariants-on-symplectic-and-almost-contact-metric-manifolds",totalDownloads:1507,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"In this chapter, we introduce Gromov-Witten invariant, quantum cohomology, Gromov-Witten potential, and Floer cohomology on symplectic manifolds, and in connection with these, we describe Gromov-Witten type invariant, quantum type cohomology, Gromov-Witten type potential and Floer type cohomology on almost contact metric manifolds. On the product of a symplectic manifold and an almost contact metric manifold, we induce some relations between Gromov-Witten type invariant and quantum cohomology and quantum type invariant. We show that the quantum type cohomology is isomorphic to the Floer type cohomology.",book:{id:"5488",slug:"manifolds-current-research-areas",title:"Manifolds",fullTitle:"Manifolds - Current Research Areas"},signatures:"Yong Seung Cho",authors:[{id:"62522",title:"Prof.",name:"Yong Seung",middleName:null,surname:"Cho",slug:"yong-seung-cho",fullName:"Yong Seung Cho"}]},{id:"62804",title:"Recent Advances of Manifold Regularization",slug:"recent-advances-of-manifold-regularization",totalDownloads:1083,totalCrossrefCites:0,totalDimensionsCites:3,abstract:"Semi-supervised learning (SSL) that can make use of a small number of labeled data with a large number of unlabeled data to produce significant improvement in learning performance has been received considerable attention. Manifold regularization is one of the most popular works that exploits the geometry of the probability distribution that generates the data and incorporates them as regularization terms. There are many representative works of manifold regularization including Laplacian regularization (LapR), Hessian regularization (HesR) and p-Laplacian regularization (pLapR). Based on the manifold regularization framework, many extensions and applications have been reported. In the chapter, we review the LapR and HesR, and we introduce an approximation algorithm of graph p-Laplacian. We study several extensions of this framework for pairwise constraint, p-Laplacian learning, hypergraph learning, etc.",book:{id:"7342",slug:"manifolds-ii-theory-and-applications",title:"Manifolds II",fullTitle:"Manifolds II - Theory and Applications"},signatures:"Xueqi Ma and Weifeng Liu",authors:null},{id:"53552",title:"Sub-Manifolds of a Riemannian Manifold",slug:"sub-manifolds-of-a-riemannian-manifold",totalDownloads:1740,totalCrossrefCites:1,totalDimensionsCites:1,abstract:"In this chapter, we introduce the theory of sub-manifolds of a Riemannian manifold. The fundamental notations are given. The theory of sub-manifolds of an almost Riemannian product manifold is one of the most interesting topics in differential geometry. According to the behaviour of the tangent bundle of a sub-manifold, with respect to the action of almost Riemannian product structure of the ambient manifolds, we have three typical classes of sub-manifolds such as invariant sub-manifolds, anti-invariant sub-manifolds and semi-invariant sub-manifolds. In addition, slant, semi-slant and pseudo-slant sub-manifolds are introduced by many geometers.",book:{id:"5488",slug:"manifolds-current-research-areas",title:"Manifolds",fullTitle:"Manifolds - Current Research Areas"},signatures:"Mehmet Atçeken, Ümit Yıldırım and Süleyman Dirik",authors:[{id:"191326",title:"Prof.",name:"Mehmet",middleName:null,surname:"Atceken",slug:"mehmet-atceken",fullName:"Mehmet Atceken"},{id:"196148",title:"Dr.",name:"Umit",middleName:null,surname:"Yildirim",slug:"umit-yildirim",fullName:"Umit Yildirim"}]},{id:"52886",title:"Head Pose Estimation via Manifold Learning",slug:"head-pose-estimation-via-manifold-learning",totalDownloads:1817,totalCrossrefCites:4,totalDimensionsCites:3,abstract:"For the last decades, manifold learning has shown its advantage of efficient non-linear dimensionality reduction in data analysis. Based on the assumption that informative and discriminative representation of the data lies on a low-dimensional smooth manifold which implicitly embedded in the original high-dimensional space, manifold learning aims to learn the low-dimensional representation following some geometrical protocols, such as preserving piecewise local structure of the original data. Manifold learning also plays an important role in the applications of computer vision, i.e., face image analysis. According to the observations that many face-related research is benefitted by the head pose estimation, and the continuous variation of head pose can be modelled and interpreted as a low-dimensional smooth manifold, we will focus on the head pose estimation via manifold learning in this chapter. Generally, head pose is hard to directly explore from the high-dimensional space interpreted as face images, which is, however, can be efficiently represented in low-dimensional manifold. Therefore, in this chapter, classical manifold learning algorithms are introduced and the corresponding application on head pose estimation are elaborated. Several extensions of manifold learning algorithms which are developed especially for head pose estimation are also discussed and compared.",book:{id:"5488",slug:"manifolds-current-research-areas",title:"Manifolds",fullTitle:"Manifolds - Current Research Areas"},signatures:"Chao Wang, Yuanhao Guo and Xubo Song",authors:[{id:"190308",title:"Dr.",name:"Chao",middleName:null,surname:"Wang",slug:"chao-wang",fullName:"Chao Wang"},{id:"190461",title:"Prof.",name:"Xubo",middleName:null,surname:"Song",slug:"xubo-song",fullName:"Xubo Song"},{id:"191562",title:"MSc.",name:"Yuanhao",middleName:null,surname:"Guo",slug:"yuanhao-guo",fullName:"Yuanhao Guo"}]}],onlineFirstChaptersFilter:{topicId:"165",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:89,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:31,numberOfPublishedChapters:314,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:11,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:105,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:17,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:5,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:14,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"14",title:"Artificial Intelligence",doi:"10.5772/intechopen.79920",issn:"2633-1403",scope:"Artificial Intelligence (AI) is a rapidly developing multidisciplinary research area that aims to solve increasingly complex problems. In today's highly integrated world, AI promises to become a robust and powerful means for obtaining solutions to previously unsolvable problems. This Series is intended for researchers and students alike interested in this fascinating field and its many applications.",coverUrl:"https://cdn.intechopen.com/series/covers/14.jpg",latestPublicationDate:"June 11th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:9,editor:{id:"218714",title:"Prof.",name:"Andries",middleName:null,surname:"Engelbrecht",slug:"andries-engelbrecht",fullName:"Andries Engelbrecht",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRNR8QAO/Profile_Picture_1622640468300",biography:"Andries Engelbrecht received the Masters and PhD degrees in Computer Science from the University of Stellenbosch, South Africa, in 1994 and 1999 respectively. He is currently appointed as the Voigt Chair in Data Science in the Department of Industrial Engineering, with a joint appointment as Professor in the Computer Science Division, Stellenbosch University. Prior to his appointment at Stellenbosch University, he has been at the University of Pretoria, Department of Computer Science (1998-2018), where he was appointed as South Africa Research Chair in Artifical Intelligence (2007-2018), the head of the Department of Computer Science (2008-2017), and Director of the Institute for Big Data and Data Science (2017-2018). In addition to a number of research articles, he has written two books, Computational Intelligence: An Introduction and Fundamentals of Computational Swarm Intelligence.",institutionString:null,institution:{name:"Stellenbosch University",institutionURL:null,country:{name:"South Africa"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:6,paginationItems:[{id:"22",title:"Applied Intelligence",coverUrl:"https://cdn.intechopen.com/series_topics/covers/22.jpg",isOpenForSubmission:!0,editor:{id:"27170",title:"Prof.",name:"Carlos",middleName:"M.",surname:"Travieso-Gonzalez",slug:"carlos-travieso-gonzalez",fullName:"Carlos Travieso-Gonzalez",profilePictureURL:"https://mts.intechopen.com/storage/users/27170/images/system/27170.jpeg",biography:"Carlos M. Travieso-González received his MSc degree in Telecommunication Engineering at Polytechnic University of Catalonia (UPC), Spain in 1997, and his Ph.D. degree in 2002 at the University of Las Palmas de Gran Canaria (ULPGC-Spain). He is a full professor of signal processing and pattern recognition and is head of the Signals and Communications Department at ULPGC, teaching from 2001 on subjects on signal processing and learning theory. His research lines are biometrics, biomedical signals and images, data mining, classification system, signal and image processing, machine learning, and environmental intelligence. He has researched in 52 international and Spanish research projects, some of them as head researcher. He is co-author of 4 books, co-editor of 27 proceedings books, guest editor for 8 JCR-ISI international journals, and up to 24 book chapters. He has over 450 papers published in international journals and conferences (81 of them indexed on JCR – ISI - Web of Science). He has published seven patents in the Spanish Patent and Trademark Office. He has been a supervisor on 8 Ph.D. theses (11 more are under supervision), and 130 master theses. He is the founder of The IEEE IWOBI conference series and the president of its Steering Committee, as well as the founder of both the InnoEducaTIC and APPIS conference series. He is an evaluator of project proposals for the European Union (H2020), Medical Research Council (MRC, UK), Spanish Government (ANECA, Spain), Research National Agency (ANR, France), DAAD (Germany), Argentinian Government, and the Colombian Institutions. He has been a reviewer in different indexed international journals (<70) and conferences (<250) since 2001. He has been a member of the IASTED Technical Committee on Image Processing from 2007 and a member of the IASTED Technical Committee on Artificial Intelligence and Expert Systems from 2011. \n\nHe has held the general chair position for the following: ACM-APPIS (2020, 2021), IEEE-IWOBI (2019, 2020 and 2020), A PPIS (2018, 2019), IEEE-IWOBI (2014, 2015, 2017, 2018), InnoEducaTIC (2014, 2017), IEEE-INES (2013), NoLISP (2011), JRBP (2012), and IEEE-ICCST (2005)\n\nHe is an associate editor of the Computational Intelligence and Neuroscience Journal (Hindawi – Q2 JCR-ISI). He was vice dean from 2004 to 2010 in the Higher Technical School of Telecommunication Engineers at ULPGC and the vice dean of Graduate and Postgraduate Studies from March 2013 to November 2017. He won the “Catedra Telefonica” Awards in Modality of Knowledge Transfer, 2017, 2018, and 2019 editions, and awards in Modality of COVID Research in 2020.\n\nPublic References:\nResearcher ID http://www.researcherid.com/rid/N-5967-2014\nORCID https://orcid.org/0000-0002-4621-2768 \nScopus Author ID https://www.scopus.com/authid/detail.uri?authorId=6602376272\nScholar Google https://scholar.google.es/citations?user=G1ks9nIAAAAJ&hl=en \nResearchGate https://www.researchgate.net/profile/Carlos_Travieso",institutionString:null,institution:{name:"University of Las Palmas de Gran Canaria",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"23",title:"Computational Neuroscience",coverUrl:"https://cdn.intechopen.com/series_topics/covers/23.jpg",isOpenForSubmission:!0,editor:{id:"14004",title:"Dr.",name:"Magnus",middleName:null,surname:"Johnsson",slug:"magnus-johnsson",fullName:"Magnus Johnsson",profilePictureURL:"https://mts.intechopen.com/storage/users/14004/images/system/14004.png",biography:"Dr Magnus Johnsson is a cross-disciplinary scientist, lecturer, scientific editor and AI/machine learning consultant from Sweden. \n\nHe is currently at Malmö University in Sweden, but also held positions at Lund University in Sweden and at Moscow Engineering Physics Institute. \nHe holds editorial positions at several international scientific journals and has served as a scientific editor for books and special journal issues. \nHis research interests are wide and include, but are not limited to, autonomous systems, computer modeling, artificial neural networks, artificial intelligence, cognitive neuroscience, cognitive robotics, cognitive architectures, cognitive aids and the philosophy of mind. \n\nDr. Johnsson has experience from working in the industry and he has a keen interest in the application of neural networks and artificial intelligence to fields like industry, finance, and medicine. \n\nWeb page: www.magnusjohnsson.se",institutionString:null,institution:{name:"Malmö University",institutionURL:null,country:{name:"Sweden"}}},editorTwo:null,editorThree:null},{id:"24",title:"Computer Vision",coverUrl:"https://cdn.intechopen.com/series_topics/covers/24.jpg",isOpenForSubmission:!0,editor:{id:"294154",title:"Prof.",name:"George",middleName:null,surname:"Papakostas",slug:"george-papakostas",fullName:"George Papakostas",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002hYaGbQAK/Profile_Picture_1624519712088",biography:"George A. Papakostas has received a diploma in Electrical and Computer Engineering in 1999 and the M.Sc. and Ph.D. degrees in Electrical and Computer Engineering in 2002 and 2007, respectively, from the Democritus University of Thrace (DUTH), Greece. Dr. Papakostas serves as a Tenured Full Professor at the Department of Computer Science, International Hellenic University, Greece. Dr. Papakostas has 10 years of experience in large-scale systems design as a senior software engineer and technical manager, and 20 years of research experience in the field of Artificial Intelligence. Currently, he is the Head of the “Visual Computing” division of HUman-MAchines INteraction Laboratory (HUMAIN-Lab) and the Director of the MPhil program “Advanced Technologies in Informatics and Computers” hosted by the Department of Computer Science, International Hellenic University. He has (co)authored more than 150 publications in indexed journals, international conferences and book chapters, 1 book (in Greek), 3 edited books, and 5 journal special issues. His publications have more than 2100 citations with h-index 27 (GoogleScholar). His research interests include computer/machine vision, machine learning, pattern recognition, computational intelligence. \nDr. Papakostas served as a reviewer in numerous journals, as a program\ncommittee member in international conferences and he is a member of the IAENG, MIR Labs, EUCogIII, INSTICC and the Technical Chamber of Greece (TEE).",institutionString:null,institution:{name:"International Hellenic University",institutionURL:null,country:{name:"Greece"}}},editorTwo:null,editorThree:null},{id:"25",title:"Evolutionary Computation",coverUrl:"https://cdn.intechopen.com/series_topics/covers/25.jpg",isOpenForSubmission:!0,editor:{id:"136112",title:"Dr.",name:"Sebastian",middleName:null,surname:"Ventura Soto",slug:"sebastian-ventura-soto",fullName:"Sebastian Ventura Soto",profilePictureURL:"https://mts.intechopen.com/storage/users/136112/images/system/136112.png",biography:"Sebastian Ventura is a Spanish researcher, a full professor with the Department of Computer Science and Numerical Analysis, University of Córdoba. Dr Ventura also holds the positions of Affiliated Professor at Virginia Commonwealth University (Richmond, USA) and Distinguished Adjunct Professor at King Abdulaziz University (Jeddah, Saudi Arabia). Additionally, he is deputy director of the Andalusian Research Institute in Data Science and Computational Intelligence (DaSCI) and heads the Knowledge Discovery and Intelligent Systems Research Laboratory. He has published more than ten books and over 300 articles in journals and scientific conferences. Currently, his work has received over 18,000 citations according to Google Scholar, including more than 2200 citations in 2020. In the last five years, he has published more than 60 papers in international journals indexed in the JCR (around 70% of them belonging to first quartile journals) and he has edited some Springer books “Supervised Descriptive Pattern Mining” (2018), “Multiple Instance Learning - Foundations and Algorithms” (2016), and “Pattern Mining with Evolutionary Algorithms” (2016). He has also been involved in more than 20 research projects supported by the Spanish and Andalusian governments and the European Union. He currently belongs to the editorial board of PeerJ Computer Science, Information Fusion and Engineering Applications of Artificial Intelligence journals, being also associate editor of Applied Computational Intelligence and Soft Computing and IEEE Transactions on Cybernetics. Finally, he is editor-in-chief of Progress in Artificial Intelligence. He is a Senior Member of the IEEE Computer, the IEEE Computational Intelligence, and the IEEE Systems, Man, and Cybernetics Societies, and the Association of Computing Machinery (ACM). Finally, his main research interests include data science, computational intelligence, and their applications.",institutionString:null,institution:{name:"University of Córdoba",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"26",title:"Machine Learning and Data Mining",coverUrl:"https://cdn.intechopen.com/series_topics/covers/26.jpg",isOpenForSubmission:!0,editor:{id:"24555",title:"Dr.",name:"Marco Antonio",middleName:null,surname:"Aceves Fernandez",slug:"marco-antonio-aceves-fernandez",fullName:"Marco Antonio Aceves Fernandez",profilePictureURL:"https://mts.intechopen.com/storage/users/24555/images/system/24555.jpg",biography:"Dr. Marco Antonio Aceves Fernandez obtained his B.Sc. (Eng.) in Telematics from the Universidad de Colima, Mexico. He obtained both his M.Sc. and Ph.D. from the University of Liverpool, England, in the field of Intelligent Systems. He is a full professor at the Universidad Autonoma de Queretaro, Mexico, and a member of the National System of Researchers (SNI) since 2009. Dr. Aceves Fernandez has published more than 80 research papers as well as a number of book chapters and congress papers. He has contributed in more than 20 funded research projects, both academic and industrial, in the area of artificial intelligence, ranging from environmental, biomedical, automotive, aviation, consumer, and robotics to other applications. He is also a honorary president at the National Association of Embedded Systems (AMESE), a senior member of the IEEE, and a board member of many institutions. His research interests include intelligent and embedded systems.",institutionString:"Universidad Autonoma de Queretaro",institution:{name:"Autonomous University of Queretaro",institutionURL:null,country:{name:"Mexico"}}},editorTwo:null,editorThree:null},{id:"27",title:"Multi-Agent Systems",coverUrl:"https://cdn.intechopen.com/series_topics/covers/27.jpg",isOpenForSubmission:!0,editor:{id:"148497",title:"Dr.",name:"Mehmet",middleName:"Emin",surname:"Aydin",slug:"mehmet-aydin",fullName:"Mehmet Aydin",profilePictureURL:"https://mts.intechopen.com/storage/users/148497/images/system/148497.jpg",biography:"Dr. Mehmet Emin Aydin is a Senior Lecturer with the Department of Computer Science and Creative Technology, the University of the West of England, Bristol, UK. His research interests include swarm intelligence, parallel and distributed metaheuristics, machine learning, intelligent agents and multi-agent systems, resource planning, scheduling and optimization, combinatorial optimization. Dr. Aydin is currently a Fellow of Higher Education Academy, UK, a member of EPSRC College, a senior member of IEEE and a senior member of ACM. In addition to being a member of advisory committees of many international conferences, he is an Editorial Board Member of various peer-reviewed international journals. He has served as guest editor for a number of special issues of peer-reviewed international journals.",institutionString:null,institution:{name:"University of the West of England",institutionURL:null,country:{name:"United Kingdom"}}},editorTwo:null,editorThree:null}]},overviewPageOFChapters:{paginationCount:19,paginationItems:[{id:"82196",title:"Multi-Features Assisted Age Invariant Face Recognition and Retrieval Using CNN with Scale Invariant Heat Kernel Signature",doi:"10.5772/intechopen.104944",signatures:"Kamarajugadda Kishore Kumar and Movva Pavani",slug:"multi-features-assisted-age-invariant-face-recognition-and-retrieval-using-cnn-with-scale-invariant-",totalDownloads:6,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Pattern Recognition - New Insights",coverURL:"https://cdn.intechopen.com/books/images_new/11442.jpg",subseries:{id:"26",title:"Machine Learning and Data Mining"}}},{id:"82063",title:"Evaluating Similarities and Differences between Machine Learning and Traditional Statistical Modeling in Healthcare Analytics",doi:"10.5772/intechopen.105116",signatures:"Michele Bennett, Ewa J. Kleczyk, Karin Hayes and Rajesh Mehta",slug:"evaluating-similarities-and-differences-between-machine-learning-and-traditional-statistical-modelin",totalDownloads:6,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Machine Learning and Data Mining - Annual Volume 2022",coverURL:"https://cdn.intechopen.com/books/images_new/11422.jpg",subseries:{id:"26",title:"Machine Learning and Data Mining"}}},{id:"81791",title:"Self-Supervised Contrastive Representation Learning in Computer Vision",doi:"10.5772/intechopen.104785",signatures:"Yalin Bastanlar and Semih Orhan",slug:"self-supervised-contrastive-representation-learning-in-computer-vision",totalDownloads:23,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Pattern Recognition - New Insights",coverURL:"https://cdn.intechopen.com/books/images_new/11442.jpg",subseries:{id:"26",title:"Machine Learning and Data Mining"}}},{id:"79345",title:"Application of Jump Diffusion Models in Insurance Claim Estimation",doi:"10.5772/intechopen.99853",signatures:"Leonard Mushunje, Chiedza Elvina Mashiri, Edina Chandiwana and Maxwell Mashasha",slug:"application-of-jump-diffusion-models-in-insurance-claim-estimation-1",totalDownloads:8,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Data Clustering",coverURL:"https://cdn.intechopen.com/books/images_new/10820.jpg",subseries:{id:"26",title:"Machine Learning and Data Mining"}}}]},overviewPagePublishedBooks:{paginationCount:9,paginationItems:[{type:"book",id:"7723",title:"Artificial Intelligence",subtitle:"Applications in Medicine and Biology",coverURL:"https://cdn.intechopen.com/books/images_new/7723.jpg",slug:"artificial-intelligence-applications-in-medicine-and-biology",publishedDate:"July 31st 2019",editedByType:"Edited by",bookSignature:"Marco Antonio Aceves-Fernandez",hash:"a3852659e727f95c98c740ed98146011",volumeInSeries:1,fullTitle:"Artificial Intelligence - Applications in Medicine and Biology",editors:[{id:"24555",title:"Dr.",name:"Marco Antonio",middleName:null,surname:"Aceves Fernandez",slug:"marco-antonio-aceves-fernandez",fullName:"Marco Antonio Aceves Fernandez",profilePictureURL:"https://mts.intechopen.com/storage/users/24555/images/system/24555.jpg",biography:"Dr. Marco Antonio Aceves Fernandez obtained his B.Sc. (Eng.) in Telematics from the Universidad de Colima, Mexico. He obtained both his M.Sc. and Ph.D. from the University of Liverpool, England, in the field of Intelligent Systems. He is a full professor at the Universidad Autonoma de Queretaro, Mexico, and a member of the National System of Researchers (SNI) since 2009. Dr. Aceves Fernandez has published more than 80 research papers as well as a number of book chapters and congress papers. He has contributed in more than 20 funded research projects, both academic and industrial, in the area of artificial intelligence, ranging from environmental, biomedical, automotive, aviation, consumer, and robotics to other applications. He is also a honorary president at the National Association of Embedded Systems (AMESE), a senior member of the IEEE, and a board member of many institutions. His research interests include intelligent and embedded systems.",institutionString:"Universidad Autonoma de Queretaro",institution:{name:"Autonomous University of Queretaro",institutionURL:null,country:{name:"Mexico"}}}]},{type:"book",id:"7726",title:"Swarm Intelligence",subtitle:"Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/7726.jpg",slug:"swarm-intelligence-recent-advances-new-perspectives-and-applications",publishedDate:"December 4th 2019",editedByType:"Edited by",bookSignature:"Javier Del Ser, Esther Villar and Eneko Osaba",hash:"e7ea7e74ce7a7a8e5359629e07c68d31",volumeInSeries:2,fullTitle:"Swarm Intelligence - Recent Advances, New Perspectives and Applications",editors:[{id:"49813",title:"Dr.",name:"Javier",middleName:null,surname:"Del Ser",slug:"javier-del-ser",fullName:"Javier Del Ser",profilePictureURL:"https://mts.intechopen.com/storage/users/49813/images/system/49813.png",biography:"Prof. Dr. Javier Del Ser received his first PhD in Telecommunication Engineering (Cum Laude) from the University of Navarra, Spain, in 2006, and a second PhD in Computational Intelligence (Summa Cum Laude) from the University of Alcala, Spain, in 2013. He is currently a principal researcher in data analytics and optimisation at TECNALIA (Spain), a visiting fellow at the Basque Center for Applied Mathematics (BCAM) and a part-time lecturer at the University of the Basque Country (UPV/EHU). His research interests gravitate on the use of descriptive, prescriptive and predictive algorithms for data mining and optimization in a diverse range of application fields such as Energy, Transport, Telecommunications, Health and Industry, among others. In these fields he has published more than 240 articles, co-supervised 8 Ph.D. theses, edited 6 books, coauthored 7 patents and participated/led more than 40 research projects. 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He worked as a post-doctoral fellow at the Public Health Research Institute (PHRI), Newark, NJ for four years before accepting a three-year faculty position at Brigham Young University-Hawaii. Dr. Engohang-Ndong is a tenured faculty member with the academic rank of Full Professor at Kent State University, Ohio, where he teaches a wide range of biological science courses and pursues his research in medical and environmental microbiology. 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He has an excellent track record in the herpesvirus field, and his group is engaged in clinical research in the field of Epstein-Barr virus diseases. He is the editor of the online Encyclopedia of Environment and he coordinates the Universal Health Coverage education program for the BioHealth Computing Schools of the European Institute of Science.",institutionString:null,institution:{name:"Grenoble Alpes University",country:{name:"France"}}},{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",biography:"Dr. Rodriguez-Morales is an expert in tropical and emerging diseases, particularly zoonotic and vector-borne diseases (especially arboviral diseases). He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},{id:"332819",title:"Dr.",name:"Chukwudi Michael",middleName:"Michael",surname:"Egbuche",slug:"chukwudi-michael-egbuche",fullName:"Chukwudi Michael Egbuche",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/332819/images/14624_n.jpg",biography:"I an Dr. Chukwudi Michael Egbuche. I am a Senior Lecturer in the Department of Parasitology and Entomology, Nnamdi Azikiwe University, Awka.",institutionString:null,institution:{name:"Nnamdi Azikiwe University",country:{name:"Nigeria"}}},{id:"284232",title:"Mr.",name:"Nikunj",middleName:"U",surname:"Tandel",slug:"nikunj-tandel",fullName:"Nikunj Tandel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/284232/images/8275_n.jpg",biography:'Mr. Nikunj Tandel has completed his Master\'s degree in Biotechnology from VIT University, India in the year of 2012. He is having 8 years of research experience especially in the field of malaria epidemiology, immunology, and nanoparticle-based drug delivery system against the infectious diseases, autoimmune disorders and cancer. He has worked for the NIH funded-International Center of Excellence in Malaria Research project "Center for the study of complex malaria in India (CSCMi)" in collaboration with New York University. The preliminary objectives of the study are to understand and develop the evidence-based tools and interventions for the control and prevention of malaria in different sites of the INDIA. Alongside, with the help of next-generation genomics study, the team has studied the antimalarial drug resistance in India. Further, he has extended his research in the development of Humanized mice for the study of liver-stage malaria and identification of molecular marker(s) for the Artemisinin resistance. At present, his research focuses on understanding the role of B cells in the activation of CD8+ T cells in malaria. Received the CSIR-SRF (Senior Research Fellow) award-2018, FIMSA (Federation of Immunological Societies of Asia-Oceania) Travel Bursary award to attend the IUIS-IIS-FIMSA Immunology course-2019',institutionString:"Nirma University",institution:{name:"Nirma University",country:{name:"India"}}},{id:"334383",title:"Ph.D.",name:"Simone",middleName:"Ulrich",surname:"Ulrich Picoli",slug:"simone-ulrich-picoli",fullName:"Simone Ulrich Picoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334383/images/15919_n.jpg",biography:"Graduated in Pharmacy from Universidade Luterana do Brasil (1999), Master in Agricultural and Environmental Microbiology from Federal University of Rio Grande do Sul (2002), Specialization in Clinical Microbiology from Universidade de São Paulo, USP (2007) and PhD in Sciences in Gastroenterology and Hepatology (2012). She is currently an Adjunct Professor at Feevale University in Medicine and Biomedicine courses and a permanent professor of the Academic Master\\'s Degree in Virology. She has experience in the field of Microbiology, with an emphasis on Bacteriology, working mainly on the following topics: bacteriophages, bacterial resistance, clinical microbiology and food microbiology.",institutionString:null,institution:{name:"Universidade Feevale",country:{name:"Brazil"}}},{id:"229220",title:"Dr.",name:"Amjad",middleName:"Islam",surname:"Aqib",slug:"amjad-aqib",fullName:"Amjad Aqib",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229220/images/system/229220.png",biography:"Dr. Amjad Islam Aqib obtained a DVM and MSc (Hons) from University of Agriculture Faisalabad (UAF), Pakistan, and a PhD from the University of Veterinary and Animal Sciences Lahore, Pakistan. Dr. Aqib joined the Department of Clinical Medicine and Surgery at UAF for one year as an assistant professor where he developed a research laboratory designated for pathogenic bacteria. Since 2018, he has been Assistant Professor/Officer in-charge, Department of Medicine, Manager Research Operations and Development-ORIC, and President One Health Club at Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan. He has nearly 100 publications to his credit. His research interests include epidemiological patterns and molecular analysis of antimicrobial resistance and modulation and vaccine development against animal pathogens of public health concern.",institutionString:"Cholistan University of Veterinary and Animal Sciences",institution:null},{id:"62900",title:"Prof.",name:"Fethi",middleName:null,surname:"Derbel",slug:"fethi-derbel",fullName:"Fethi Derbel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/62900/images/system/62900.jpeg",biography:"Professor Fethi Derbel was born in 1960 in Tunisia. He received his medical degree from the Sousse Faculty of Medicine at Sousse, University of Sousse, Tunisia. He completed his surgical residency in General Surgery at the University Hospital Farhat Hached of Sousse and was a member of the Unit of Liver Transplantation in the University of Rennes, France. He then worked in the Department of Surgery at the Sahloul University Hospital in Sousse. Professor Derbel is presently working at the Clinique les Oliviers, Sousse, Tunisia. His hospital activities are mostly concerned with laparoscopic, colorectal, pancreatic, hepatobiliary, and gastric surgery. He is also very interested in hernia surgery and performs ventral hernia repairs and inguinal hernia repairs. He has been a member of the GREPA and Tunisian Hernia Society (THS). During his residency, he managed patients suffering from diabetic foot, and he was very interested in this pathology. For this reason, he decided to coordinate a book project dealing with the diabetic foot. Professor Derbel has published many articles in journals and collaborates intensively with IntechOpen Access Publisher as an editor.",institutionString:"Clinique les Oliviers",institution:null},{id:"300144",title:"Dr.",name:"Meriem",middleName:null,surname:"Braiki",slug:"meriem-braiki",fullName:"Meriem Braiki",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/300144/images/system/300144.jpg",biography:"Dr. Meriem Braiki is a specialist in pediatric surgeon from Tunisia. She was born in 1985. She received her medical degree from the University of Medicine at Sousse, Tunisia. She achieved her surgical residency training periods in Pediatric Surgery departments at University Hospitals in Monastir, Tunis and France.\r\nShe is currently working at the Pediatric surgery department, Sidi Bouzid Hospital, Tunisia. Her hospital activities are mostly concerned with laparoscopic, parietal, urological and digestive surgery. She has published several articles in diffrent journals.",institutionString:"Sidi Bouzid Regional Hospital",institution:null},{id:"229481",title:"Dr.",name:"Erika M.",middleName:"Martins",surname:"de Carvalho",slug:"erika-m.-de-carvalho",fullName:"Erika M. de Carvalho",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229481/images/6397_n.jpg",biography:null,institutionString:null,institution:{name:"Oswaldo Cruz Foundation",country:{name:"Brazil"}}},{id:"186537",title:"Prof.",name:"Tonay",middleName:null,surname:"Inceboz",slug:"tonay-inceboz",fullName:"Tonay Inceboz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/186537/images/system/186537.jfif",biography:"I was graduated from Ege University of Medical Faculty (Turkey) in 1988 and completed his Med. PhD degree in Medical Parasitology at the same university. I became an Associate Professor in 2008 and Professor in 2014. I am currently working as a Professor at the Department of Medical Parasitology at Dokuz Eylul University, Izmir, Turkey.\n\nI have given many lectures, presentations in different academic meetings. I have more than 60 articles in peer-reviewed journals, 18 book chapters, 1 book editorship.\n\nMy research interests are Echinococcus granulosus, Echinococcus multilocularis (diagnosis, life cycle, in vitro and in vivo cultivation), and Trichomonas vaginalis (diagnosis, PCR, and in vitro cultivation).",institutionString:"Dokuz Eylül University",institution:{name:"Dokuz Eylül University",country:{name:"Turkey"}}},{id:"71812",title:"Prof.",name:"Hanem Fathy",middleName:"Fathy",surname:"Khater",slug:"hanem-fathy-khater",fullName:"Hanem Fathy Khater",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/71812/images/1167_n.jpg",biography:"Prof. Khater is a Professor of Parasitology at Benha University, Egypt. She studied for her doctoral degree, at the Department of Entomology, College of Agriculture, Food and Natural Resources, University of Missouri, Columbia, USA. She has completed her Ph.D. degrees in Parasitology in Egypt, from where she got the award for “the best scientific Ph.D. dissertation”. She worked at the School of Biological Sciences, Bristol, England, the UK in controlling insects of medical and veterinary importance as a grant from Newton Mosharafa, the British Council. Her research is focused on searching of pesticides against mosquitoes, house flies, lice, green bottle fly, camel nasal botfly, soft and hard ticks, mites, and the diamondback moth as well as control of several parasites using safe and natural materials to avoid drug resistances and environmental contamination.",institutionString:null,institution:{name:"Banha University",country:{name:"Egypt"}}},{id:"99780",title:"Prof.",name:"Omolade",middleName:"Olayinka",surname:"Okwa",slug:"omolade-okwa",fullName:"Omolade Okwa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/99780/images/system/99780.jpg",biography:"Omolade Olayinka Okwa is presently a Professor of Parasitology at Lagos State University, Nigeria. She has a PhD in Parasitology (1997), an MSc in Cellular Parasitology (1992), and a BSc (Hons) Zoology (1990) all from the University of Ibadan, Nigeria. She teaches parasitology at the undergraduate and postgraduate levels. She was a recipient of a Commonwealth fellowship supported by British Council tenable at the Centre for Entomology and Parasitology (CAEP), Keele University, United Kingdom between 2004 and 2005. She was awarded an Honorary Visiting Research Fellow at the same university from 2005 to 2007. \nShe has been an external examiner to the Department of Veterinary Microbiology and Parasitology, University of Ibadan, MSc programme between 2010 and 2012. She is a member of the Nigerian Society of Experimental Biology (NISEB), Parasitology and Public Health Society of Nigeria (PPSN), Science Association of Nigeria (SAN), Zoological Society of Nigeria (ZSN), and is Vice Chairperson of the Organisation of Women in Science (OWSG), LASU chapter. She served as Head of Department of Zoology and Environmental Biology, Lagos State University from 2007 to 2010 and 2014 to 2016. She is a reviewer for several local and international journals such as Unilag Journal of Science, Libyan Journal of Medicine, Journal of Medicine and Medical Sciences, and Annual Research and Review in Science. \nShe has authored 45 scientific research publications in local and international journals, 8 scientific reviews, 4 books, and 3 book chapters, which includes the books “Malaria Parasites” and “Malaria” which are IntechOpen access publications.",institutionString:"Lagos State University",institution:{name:"Lagos State University",country:{name:"Nigeria"}}},{id:"273100",title:"Dr.",name:"Vijay",middleName:null,surname:"Gayam",slug:"vijay-gayam",fullName:"Vijay Gayam",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/273100/images/system/273100.jpeg",biography:"Dr. Vijay Bhaskar Reddy Gayam is currently practicing as an internist at Interfaith Medical Center in Brooklyn, New York, USA. He is also a Clinical Assistant Professor at the SUNY Downstate University Hospital and Adjunct Professor of Medicine at the American University of Antigua. He is a holder of an M.B.B.S. degree bestowed to him by Osmania Medical College and received his M.D. at Interfaith Medical Center. His career goals thus far have heavily focused on direct patient care, medical education, and clinical research. He currently serves in two leadership capacities; Assistant Program Director of Medicine at Interfaith Medical Center and as a Councilor for the American\r\nFederation for Medical Research. As a true academician and researcher, he has more than 50 papers indexed in international peer-reviewed journals. He has also presented numerous papers in multiple national and international scientific conferences. His areas of research interest include general internal medicine, gastroenterology and hepatology. He serves as an editor, editorial board member and reviewer for multiple international journals. His research on Hepatitis C has been very successful and has led to multiple research awards, including the 'Equity in Prevention and Treatment Award” from the New York Department of Health Viral Hepatitis Symposium (2018) and the 'Presidential Poster Award” awarded to him by the American College of Gastroenterology (2018). He was also awarded 'Outstanding Clinician in General Medicine” by Venus International Foundation for his extensive research expertise and services, perform over and above the standard expected in the advancement of healthcare, patient safety and quality of care.",institutionString:"Interfaith Medical Center",institution:{name:"Interfaith Medical Center",country:{name:"United States of America"}}},{id:"93517",title:"Dr.",name:"Clement",middleName:"Adebajo",surname:"Meseko",slug:"clement-meseko",fullName:"Clement Meseko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/93517/images/system/93517.jpg",biography:"Dr. Clement Meseko obtained DVM and PhD degree in Veterinary Medicine and Virology respectively. He has worked for over 20 years in both private and public sectors including the academia, contributing to knowledge and control of infectious disease. Through the application of epidemiological skill, classical and molecular virological skills, he investigates viruses of economic and public health importance for the mitigation of the negative impact on people, animal and the environment in the context of Onehealth. \r\nDr. Meseko’s field experience on animal and zoonotic diseases and pathogen dynamics at the human-animal interface over the years shaped his carrier in research and scientific inquiries. He has been part of the investigation of Highly Pathogenic Avian Influenza incursions in sub Saharan Africa and monitors swine Influenza (Pandemic influenza Virus) agro-ecology and potential for interspecies transmission. He has authored and reviewed a number of journal articles and book chapters.",institutionString:"National Veterinary Research Institute",institution:{name:"National Veterinary Research Institute",country:{name:"Nigeria"}}},{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",country:{name:"India"}}},{id:"94928",title:"Dr.",name:"Takuo",middleName:null,surname:"Mizukami",slug:"takuo-mizukami",fullName:"Takuo Mizukami",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94928/images/6402_n.jpg",biography:null,institutionString:null,institution:{name:"National Institute of Infectious Diseases",country:{name:"Japan"}}},{id:"233433",title:"Dr.",name:"Yulia",middleName:null,surname:"Desheva",slug:"yulia-desheva",fullName:"Yulia Desheva",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/233433/images/system/233433.png",biography:"Dr. Yulia Desheva is a leading researcher at the Institute of Experimental Medicine, St. Petersburg, Russia. She is a professor in the Stomatology Faculty, St. Petersburg State University. She has expertise in the development and evaluation of a wide range of live mucosal vaccines against influenza and bacterial complications. Her research interests include immunity against influenza and COVID-19 and the development of immunization schemes for high-risk individuals.",institutionString:'Federal State Budgetary Scientific Institution "Institute of Experimental Medicine"',institution:null},{id:"238958",title:"Mr.",name:"Atamjit",middleName:null,surname:"Singh",slug:"atamjit-singh",fullName:"Atamjit Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/238958/images/6575_n.jpg",biography:null,institutionString:null,institution:null},{id:"333753",title:"Dr.",name:"Rais",middleName:null,surname:"Ahmed",slug:"rais-ahmed",fullName:"Rais Ahmed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/333753/images/20168_n.jpg",biography:null,institutionString:null,institution:null},{id:"252058",title:"M.Sc.",name:"Juan",middleName:null,surname:"Sulca",slug:"juan-sulca",fullName:"Juan Sulca",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252058/images/12834_n.jpg",biography:null,institutionString:null,institution:null},{id:"191392",title:"Dr.",name:"Marimuthu",middleName:null,surname:"Govindarajan",slug:"marimuthu-govindarajan",fullName:"Marimuthu Govindarajan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/191392/images/5828_n.jpg",biography:"Dr. M. Govindarajan completed his BSc degree in Zoology at Government Arts College (Autonomous), Kumbakonam, and MSc, MPhil, and PhD degrees at Annamalai University, Annamalai Nagar, Tamil Nadu, India. He is serving as an assistant professor at the Department of Zoology, Annamalai University. His research interests include isolation, identification, and characterization of biologically active molecules from plants and microbes. He has identified more than 20 pure compounds with high mosquitocidal activity and also conducted high-quality research on photochemistry and nanosynthesis. He has published more than 150 studies in journals with impact factor and 2 books in Lambert Academic Publishing, Germany. He serves as an editorial board member in various national and international scientific journals.",institutionString:null,institution:null},{id:"274660",title:"Dr.",name:"Damodar",middleName:null,surname:"Paudel",slug:"damodar-paudel",fullName:"Damodar Paudel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/274660/images/8176_n.jpg",biography:"I am DrDamodar Paudel,currently working as consultant Physician in Nepal police Hospital.",institutionString:null,institution:null},{id:"241562",title:"Dr.",name:"Melvin",middleName:null,surname:"Sanicas",slug:"melvin-sanicas",fullName:"Melvin Sanicas",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/241562/images/6699_n.jpg",biography:null,institutionString:null,institution:null},{id:"337446",title:"Dr.",name:"Maria",middleName:null,surname:"Zavala-Colon",slug:"maria-zavala-colon",fullName:"Maria Zavala-Colon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Puerto Rico, Medical Sciences Campus",country:{name:"United States of America"}}},{id:"338856",title:"Mrs.",name:"Nur Alvira",middleName:null,surname:"Pascawati",slug:"nur-alvira-pascawati",fullName:"Nur Alvira Pascawati",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universitas Respati Yogyakarta",country:{name:"Indonesia"}}},{id:"441116",title:"Dr.",name:"Jovanka M.",middleName:null,surname:"Voyich",slug:"jovanka-m.-voyich",fullName:"Jovanka M. 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Dr. Chen\\'s research interests include bioactive compounds, chromatography techniques, in vitro culture, medicinal plants, phytochemicals, and plant biotechnology. 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Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. The Proteomics topic aims to attract contributions on all aspects of MS-based proteomics that, by pushing the boundaries of MS capabilities, may address biological problems that have not been resolved yet.",annualVolume:11414,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null,editorialBoard:[{id:"72288",title:"Dr.",name:"Arli Aditya",middleName:null,surname:"Parikesit",fullName:"Arli Aditya Parikesit",profilePictureURL:"https://mts.intechopen.com/storage/users/72288/images/system/72288.jpg",institutionString:null,institution:{name:"Indonesia International Institute for Life Sciences",institutionURL:null,country:{name:"Indonesia"}}},{id:"40928",title:"Dr.",name:"Cesar",middleName:null,surname:"Lopez-Camarillo",fullName:"Cesar Lopez-Camarillo",profilePictureURL:"https://mts.intechopen.com/storage/users/40928/images/3884_n.png",institutionString:null,institution:{name:"Universidad Autónoma de la Ciudad de México",institutionURL:null,country:{name:"Mexico"}}},{id:"81926",title:"Dr.",name:"Shymaa",middleName:null,surname:"Enany",fullName:"Shymaa Enany",profilePictureURL:"https://mts.intechopen.com/storage/users/81926/images/system/81926.png",institutionString:"Suez Canal University",institution:{name:"Suez Canal University",institutionURL:null,country:{name:"Egypt"}}}]}]}},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"chapter.detail",path:"/chapters/10948",hash:"",query:{},params:{id:"10948"},fullPath:"/chapters/10948",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()