TY - CHAP AU - Nobuo Morotomi AU - Kunihiro Sakuma AU - Kotomi Sakai ED - Kunihiro Sakuma Y1 - 2021-04-10 PY - 2021 T1 - Exercise Therapy for Patients with Heart Failure: Focusing on the Pathophysiology of Skeletal Muscle N2 - The loss of skeletal muscle mass and strength substantially impairs physical performance and quality of life. This book details some approaches to the treatment of muscle wasting. It also reviews novel applications against pulmonary arterial hypertension such as cell reprogramming and the use of anticancer drugs that induce programmed cell death. Vascular smooth muscle cells (VSMCs) are the most prevalent cell types in blood vessels and serve critical regulatory roles. This publication also introduces mathematical models concerning the molecular mechanism and targets of cyclic guanosine 3′,5′-monophosphate (cGMP) in the contraction of VSMCs. This book will be of interest to professionals in clinical practice, medical and health care students, and researchers working in muscle-related fields of science. BT - Muscle Cell and Tissue SP - Ch. 1 UR - https://doi.org/10.5772/intechopen.97291 DO - 10.5772/intechopen.97291 SN - 978-1-83968-651-1 PB - IntechOpen CY - Rijeka Y2 - 2024-04-19 ER -