TY  - CHAP
AU  - Jia Guo
AU  - Jianglin Zhang
ED  - Xianquan Zhan
Y1  - 2020-11-23
PY  - 2020
T1  - Ubiquitination and Deubiquitination in Melanoma Research and Clinically Relevant Outcomes
N2  - The ubiquitin-proteasome pathway consists of ubiquitin, substrate proteins, E1 enzymes, E2 enzymes, E3 enzymes, and proteasome, which acts in a series of enzymatic reaction chains to ubiquitinate substrate proteins such as surplus and misfolded proteins for degradation by the proteasome to maintain the balance between protein synthesis and degradation in a cell and tissue. Moreover, deubiquitinating enzymes can remove the attached ubiquitin chain, which results in a reverse ubiquitination-deubiquitination process involved in multiple biological processes in a cell and tissue. The changes of components in the ubiquitin-proteasome pathway are associated with multiple pathophysiological processes, such as cancers and neurodegenerative diseases. This book presents the new advances in concepts, analytical methodology, and application of ubiquitin-proteasome pathway for clarification of molecular mechanisms and discovery of new therapeutic targets and drugs in different diseases.
BT  - Ubiquitin
SP  - Ch. 4
UR  - https://doi.org/10.5772/intechopen.94512
DO  - 10.5772/intechopen.94512
SN  - 978-1-83880-841-9
PB  - IntechOpen
CY  - Rijeka
Y2  - 2024-04-23
ER  -