TY - CHAP AU - Alejando Córdova Izquierdo AU - Adrian Emmanuel Iglesias Reyes AU - Alda Roció Ortiz Muñiz AU - María de Lourdes Juárez Mosqueda AU - Jesús Alberto Guevara González AU - Juan Eulogio Guerra Liera AU - Gustavo Ruiz Lang AU - Rubén Huerta Crispín AU - Abel E. Villa Mancera AU - Pedro Sánchez Aparico AU - Raúl Sánchez Sánchez ED - Margarete Dulce Bagatini Y1 - 2020-08-26 PY - 2020 T1 - Effect of Oxidative Stress on Sperm Cells N2 - The imbalance between the production of reactive oxygen species (ROS) and antioxidant defenses determines a state known as oxidative stress. Higher levels of pro-oxidants compared to antioxidant defenses may generate oxidative damage, which, in turn, may lead to modifications in cellular proteins, lipids, and DNA, reducing functional capacity and increasing the risk of diseases. Nevertheless, the clearance of harmful reactive chemical species is achieved by the antioxidant defense systems. These protection systems are referred to as the first and second lines of defense and comprise the classic antioxidants, enzymatic and nonenzymatic defenses, including glutathione. This book presents and discusses the advancement of research on health and diseases and their underlying mechanisms, exploring mainly aspects related to the glutathione antioxidant system. BT - Glutathione System and Oxidative Stress in Health and Disease SP - Ch. 6 UR - https://doi.org/10.5772/intechopen.88499 DO - 10.5772/intechopen.88499 SN - 978-1-83880-126-7 PB - IntechOpen CY - Rijeka Y2 - 2024-03-28 ER -