TY  - CHAP
AU  - Wei Wang
AU  - Qi Liang
AU  - Wei Nie
AU  - Juan Zhang
AU  - Cheng Chen
ED  - Shuji Miyagawa
Y1  - 2019-11-07
PY  - 2019
T1  - Biosafety Barrier to Xenotransplantation
N2  - Recently, remarkable progress has been made in the area of preclinical xenotransplantation experiments. Surprisingly, a heterotopic heart from the gene-editing pig continued to beat for almost 2.5 years, when implanted in the monkey abdomen, and a pig life-supporting kidney could also function for over 1.3 years in monkeys. Concerning islets, islets from gene-editing pigs could work for more than one year in monkeys. It is noteworthy that one group reported a survival of adult wild-type pig islets of over 600 days. On the other hand, the progress in these preclinical trials strongly affected not only the xenotransplantation study itself but regeneration studies to use pigs as a scaffold to foster human induced pluripotent stem cells.
BT  - Xenotransplantation
SP  - Ch. 1
UR  - https://doi.org/10.5772/intechopen.89134
DO  - 10.5772/intechopen.89134
SN  - 978-1-78985-664-4
PB  - IntechOpen
CY  - Rijeka
Y2  - 2024-04-26
ER  -