TY  - CHAP
AU  - Siti Nurul Hidayah
AU  - Manasi Gaikwad
AU  - Laura Heikaus
AU  - Hartmut Schlüter
ED  - Xianquan Zhan
Y1  - 2019-10-28
PY  - 2019
T1  - Preparing Proteoforms of Therapeutic Proteins for Top-Down Mass Spectrometry
N2  - A proteoform is the basic unit in a proteome, defined as its amino acid sequence + post-translational modifications + spatial conformation + localization + cofactors + binding partners + a function, which is the final functional performer of a gene. Studies on proteoforms offer in-depth insights and can lead to the discovery of reliable biomarkers and therapeutic targets for effective prediction, diagnosis, prognostic assessment, and therapy of disease. This book focuses on the concept, study, and applications of proteoforms. Chapters cover such topics as methodologies for identifying and preparing proteoforms, proteoform pattern alteration in pituitary adenomas, and proteoforms in leukemia.
BT  - Proteoforms
SP  - Ch. 3
UR  - https://doi.org/10.5772/intechopen.89644
DO  - 10.5772/intechopen.89644
SN  - 978-1-83880-034-5
PB  - IntechOpen
CY  - Rijeka
Y2  - 2024-05-10
ER  -