TY  - CHAP
AU  - Claudia Jara
AU  - Angie K. Torres
AU  - Margrethe A. Olesen
AU  - Cheril Tapia-Rojas
ED  - Stavros Baloyannis
Y1  - 2019-08-07
PY  - 2019
T1  - Mitochondrial Dysfunction as a Key Event during Aging: From Synaptic Failure to Memory Loss
N2  - The mitochondrion is a unique and ubiquitous organelle that contains its own genome, encoding essential proteins that are major components of the respiratory chain and energy production system. Mitochondria play a dominant role in the life and function of eukaryotic cells including neurons and glia, as their survival and activity depend upon mitochondrial energy production and supply. Besides energy production, mitochondria also play a vital role in calcium homeostasis and may induce apoptosis by excitotoxicity. Mitochondrial dysfunction is related to common neurological diseases, such as Parkinson's disease, Alzheimer's disease, Friedreich's ataxia, Huntington's disease, and Multiple Sclerosis. An efficient treatment of mitochondrial dysfunction would open new horizons in the therapeutic perspectives of a substantial number of inflammatory and degenerative neurological disorders.
BT  - Mitochondria and Brain Disorders
SP  - Ch. 5
UR  - https://doi.org/10.5772/intechopen.88445
DO  - 10.5772/intechopen.88445
SN  - 978-1-78985-532-6
PB  - IntechOpen
CY  - Rijeka
Y2  - 2024-04-24
ER  -