TY  - CHAP
AU  - Felipe L. Pérez-Gordillo
AU  - Maria Jesús Pérez de Vega
AU  - Guillermo Gerona-Navarro
AU  - Yoel Rodríguez
AU  - Diego Alvarez de la Rosa
AU  - Rosario González-Muñiz
AU  - Mercedes Martín-Martínez
ED  - Brian Harvey
ED  - Frederic Jaisser
Y1  - 2019-09-25
PY  - 2019
T1  - Advances in the Development of Non-steroidal Mineralocorticoid-receptor Antagonists
N2  - This book is an open access dissemination of the EU COST Action ADMIRE in Aldosterone/Mineralocorticoid Receptor (MR) physiology and pathophysiology. Aldosterone is the major hormone regulating blood pressure. Alterations in blood levels of aldosterone and genetic mutations in the MR receptor are major causes of hypertension and comorbidities. Many of the drugs in clinical use, and in development for treating hypertension, target aldosterone and MR actions in the kidney and cardiovascular system. The ADMIRE book assembles review chapters from 16 European ADMIRE laboratories providing the latest insights into mechanisms of aldosterone synthesis/secretion, aldosterone/MR physiology and signaling, and the pathophysiological roles of aldosterone/MR activation.<br><img src="https://cdn.intechopen.com/public/images/eu_founded.jpg" alt="EU" style="height: 85px; width: 100%; margin-top: 20px;"><span style="text-align: center; margin: auto; display: block;"><img src="https://cdn.intechopen.com/public/images/cost.jpg" alt="COST"style="height: 90px; margin-top: 20px;"><img src="https://cdn.intechopen.com/public/images/admire.jpg" alt="ADMIRE" style="height: 90px; margin-top: 20px;"></span>
BT  - Aldosterone-Mineralocorticoid Receptor
SP  - Ch. 16
UR  - https://doi.org/10.5772/intechopen.88417
DO  - 10.5772/intechopen.88417
SN  - 978-1-83962-199-4
PB  - IntechOpen
CY  - Rijeka
Y2  - 2024-04-23
ER  -