TY  - CHAP
AU  - Arne Krüger
AU  - Vinicius Gonçalves Maltarollo
AU  - Carsten Wrenger
AU  - Thales Kronenberger
ED  - Vishwanath Gaitonde
ED  - Partha Karmakar
ED  - Ashit Trivedi
Y1  - 2019-05-02
PY  - 2019
T1  - ADME Profiling in Drug Discovery and a New Path Paved on Silica
N2  - The process of drug discovery and development is a complex multistage logistics project spanned over 10-15 years with an average budget exceeding 1 billion USD. Starting with target identification and synthesizing anywhere between 10k to 15k synthetic compounds to potentially obtain the final drug that reaches the market involves a complicated maze with multiple inter- and intra-operative fields. Topics described in this book emphasize the progresses in computational applications, pharmacokinetics advances, and molecular modeling developments. In addition the book also contains special topics describing target deorphaning in Mycobacterium tuberculosis, therapy treatment of some rare diseases, and developments in the pediatric drug discovery process.
BT  - Drug Discovery and Development
SP  - Ch. 6
UR  - https://doi.org/10.5772/intechopen.86174
DO  - 10.5772/intechopen.86174
SN  - 978-1-78923-976-8
PB  - IntechOpen
CY  - Rijeka
Y2  - 2024-04-26
ER  -