TY  - CHAP
AU  - Lorraine Yamurai Bishi
AU  - Sundeep Chaitanya Vedithi
AU  - Tom L. Blundell
AU  - Grace Chitima Mugumbate
ED  - Vishwanath Gaitonde
ED  - Partha Karmakar
ED  - Ashit Trivedi
Y1  - 2019-02-01
PY  - 2019
T1  - Computational Deorphaning of <em>Mycobacterium tuberculosis</em> Targets
N2  - The process of drug discovery and development is a complex multistage logistics project spanned over 10-15 years with an average budget exceeding 1 billion USD. Starting with target identification and synthesizing anywhere between 10k to 15k synthetic compounds to potentially obtain the final drug that reaches the market involves a complicated maze with multiple inter- and intra-operative fields. Topics described in this book emphasize the progresses in computational applications, pharmacokinetics advances, and molecular modeling developments. In addition the book also contains special topics describing target deorphaning in Mycobacterium tuberculosis, therapy treatment of some rare diseases, and developments in the pediatric drug discovery process.
BT  - Drug Discovery and Development
SP  - Ch. 4
UR  - https://doi.org/10.5772/intechopen.82374
DO  - 10.5772/intechopen.82374
SN  - 978-1-78923-976-8
PB  - IntechOpen
CY  - Rijeka
Y2  - 2024-04-25
ER  -