TY - CHAP AU - Huan Wu AU - Michael Wallach AU - Olga Shimoni ED - Luis Rodrigo ED - Carlos Hernández-Lahoz Y1 - 2018-11-20 PY - 2018 T1 - Challenges with Point-Of-Care Tests (POCT) for Celiac Disease N2 - Celiac disease (CD) occurs in about 1% of people worldwide. Diagnosis rates are increasing due to a true rise in incidence, rather than increased awareness and detection. CD affects genetically susceptible individuals who are triggered by the ingestion of gluten. The disease has many clinical manifestations, ranging from severe to minimally symptomatic or non-symptomatic presentations. Diagnosis requires the presence of duodenal chronic inflammation, and most patients have circulating antibodies against tissue transglutaminase. Our understanding of the basic and clinical aspects of CD increases, which is as a major health problem of almost global occurrence. Case finding, distinguishing CD from other gluten-sensitive conditions, better care, and balanced use of resources are the current challenges. BT - Celiac Disease SP - Ch. 2 UR - https://doi.org/10.5772/intechopen.81874 DO - 10.5772/intechopen.81874 SN - 978-1-78985-050-5 PB - IntechOpen CY - Rijeka Y2 - 2024-04-25 ER -