TY  - CHAP
AU  - Min Yao
AU  - Wenjie Zheng
AU  - Li Wang
AU  - Miao Fang
AU  - Zhizhen Dong and
Dengfu Yao
ED  - Hafiz Naveed Shahzad
Y1  - 2018-09-19
PY  - 2018
T1  - Novel Mechanism of Nonalcoholic Lipid Accumulation Promoting Malignant Transformation of Hepatocytes
N2  - Neoplasm refers to an abnormal tissue growth that arises as a consequence of rapid cell proliferation and continues to grow abnormally even after terminating the stimuli that had instigated the change. It lacks partial or complete functional coordination with that of the normal tissues. Neoplasms are classified depending on the degree and type of tissues involved. Carcinogenesis is a multistep process where a plethora of endogenous and exogenous factors turns out genetic and epigenetic modifications, which collectively amend some critical cellular pathways controlling the proliferation, apoptosis, and differentiation. The cells having aberrant modifications are transformed into malignant ones of which the clonal expansion results in the development of cancer. This book provides the reader with a comprehensive overview of various cancer types along with their molecular mechanisms of initiation and progression. It also describes the current knowledge about the state-of-the-art measures being employed in cancer diagnosis and therapeutics. Particular attention is paid to make this book equally useful for students, practitioners, and expert scientists.
BT  - Neoplasm
SP  - Ch. 4
UR  - https://doi.org/10.5772/intechopen.77400
DO  - 10.5772/intechopen.77400
SN  - 978-1-78923-778-8
PB  - IntechOpen
CY  - Rijeka
Y2  - 2024-04-19
ER  -