TY  - CHAP
AU  - Juliana Ide Aoki
AU  - Sandra Marcia Muxel
AU  - Juliane Cristina Ribeiro
Fernandes
AU  - Lucile Maria Floeter-Winter
ED  - Farhat Afrin
ED  - Hassan Hemeg
Y1  - 2018-10-10
PY  - 2018
T1  - The Polyamine Pathway as a Potential Target for Leishmaniases Chemotherapy
N2  - Leishmania parasites plague the mammalian host causing high morbidity and mortality. The parasites persist in the hostile milieu, crippling its defensive arsenal. In the face of mounting resistance to an antiquated drug arsenal, new approaches are urgently desired to keep the infection at bay. Furthermore, to strengthen the leishmaniasis elimination drive, particular emphasis has to be laid on identification of new targets and vaccination strategies. This book gives a brief glimpse of the epidemiology of leishmaniasis, immune evasion, vaccination, and therapeutic modalities that may work by untangling the immunological cross-wires of pathogenic cross-talk. The Conventional treatment and its drawbacks, the prospects of phytotherapy and nanomedicines, are also discussed. The identification of drug targets with the aim of designing inhibitors is also exemplified.
BT  - Leishmaniases as Re-emerging Diseases
SP  - Ch. 7
UR  - https://doi.org/10.5772/intechopen.75867
DO  - 10.5772/intechopen.75867
SN  - 978-1-78984-102-2
PB  - IntechOpen
CY  - Rijeka
Y2  - 2024-04-26
ER  -