TY - CHAP AU - Pavel D. Lisachev AU - Mark B. Shtark ED - Ales Stuchlik Y1 - 2018-07-11 PY - 2018 T1 - Long-Term Potentiation-Associated Gene Expression: Involvement of the Tumour Protein p53 N2 - The hippocampus is an important brain region, a true central hub for memory of various kinds and other processes. Neuropsychiatric disorders such as Alzheimer's disease, drug addiction, and schizophrenia are characterized by hippocampal alterations. The dentate gyrus of the hippocampus is a site exhibiting adult neurogenesis. This book covers the topic of the hippocampus from various perspectives. It discusses adult neurogenesis, effect of enriched environments on hippocampal plasticity, and long-term potentiation-associated gene expression. The book also addresses multiscale representations of complex environments and strategies in the hippocampus-dependent spatial tasks. Finally, insight into the hippocampus as a link between negative affect and relapse to psychostimulants is provided. The book collects evidence of various hippocampal functions in healthy and disordered brain. BT - The Hippocampus SP - Ch. 3 UR - https://doi.org/10.5772/intechopen.73219 DO - 10.5772/intechopen.73219 SN - 978-1-78923-357-5 PB - IntechOpen CY - Rijeka Y2 - 2024-04-19 ER -