TY - CHAP AU - Matthew Schade AU - Jacqueline A Sanabria AU - Milad Modarresi AU - Bryan Gillon AU - Zach Hunter AU - Jacqueline Fannin AU - Amrita Mallick AU - Henri Brunengraber AU - Juan Sanabria ED - Costin Teodor Streba ED - Cristin Constantin Vere ED - Ion Rogoveanu Y1 - 2017-12-20 PY - 2017 T1 - Cellular Senescence and Their Role in Liver Metabolism in Health and Disease: Overview and Future Directions N2 - Hepatocellular carcinoma (HCC) currently ranks as the third most common cause of death. As the primary malignancy of the liver is directly related to an underlying liver condition, its incidence and profile are expected to change soon. While effective prevention programs and antiviral therapies for hepatitis B and C will lower the incidence of HCC, emerging socioeconomic issues will deliver new at-risk populations. Moreover, diagnostic techniques and protocols have undergone significant advancements. Reliance on contrast enhanced ultrasound has been re-evaluated, imaging methods being considered as sufficient diagnostic tools. Molecular characterization remains desirable, since chemotherapeutic agents still have limited applicability. In light of recent diagnostic advancements and novel therapeutic solutions, it is our belief that a comprehensive update on recent paradigm shifts and interesting upcoming developments is highly needed. BT - Hepatocellular Carcinoma SP - Ch. 4 UR - https://doi.org/10.5772/intechopen.71659 DO - 10.5772/intechopen.71659 SN - 978-1-78984-274-6 PB - IntechOpen CY - Rijeka Y2 - 2024-03-29 ER -