TY  - CHAP
AU  - Mohamad Ayajuddin
AU  - Abhik Das
AU  - Limamanen Phom
AU  - Priyanka Modi
AU  - 
Rahul Chaurasia
AU  - Zevelou Koza
AU  - Abuno Thepa
AU  - Nukshimenla Jamir
AU  - 
Pukhrambam Rajesh Singh
AU  - Sentinungla Longkumer
AU  - Pardeshi Lal
and Sarat Chandra Yenisetti
ED  - Farzana Khan Perveen
Y1  - 2018-02-28
PY  - 2018
T1  - Parkinson’s Disease: Insights from Drosophila Model
N2  - This book contains 12 chapters divided into two sections. Section 1 is "Drosophila - Model for Genetics." It covers introduction, chromosomal polymorphism, polytene chromosomes, chromosomal inversion, chromosomal evolution, cell cycle regulators in meiosis and nongenetic transgenerational inheritance in Drosophila. It also includes ecological genetics, wild-type strains, morphometric analysis, cytostatics, frequencies of early and late embryonic lethals (EEL and LEL) and mosaic imaginal discs of Drosophila for genetic analysis in biomedical research. Section 2 is "Drosophila - Model for Therapeutics." It explains Drosophila as model for human diseases, neurodegeneration, heart-kidney metabolic disorders, cancer, pathophysiology of Parkinson's disease, dopamine, neuroprotective therapeutics, mitochondrial dysfunction and translational research. It also covers Drosophila role in ubiquitin-carboxyl-terminal hydrolase-L1 (UCH-L1) protein, eye development, anti-dUCH antibody, neuropathy target esterase (NTE), organophosphorous compound-induced delayed neuropathy (OPIDN) and hereditary spastic paraplegia (HSP). It also includes substrate specificities, kinetic parameters of recombinant glutathione S-transferases E6 and E7 (DmGSTE6 and DmGSTE7), detoxification and insecticidal resistance and antiviral immunity in Drosophila.
BT  - Drosophila melanogaster
SP  - Ch. 8
UR  - https://doi.org/10.5772/intechopen.72021
DO  - 10.5772/intechopen.72021
SN  - 978-953-51-3854-9
PB  - IntechOpen
CY  - Rijeka
Y2  - 2024-04-23
ER  -