TY - CHAP AU - Chuang Wang AU - Zhen Wang AU - Mengmeng Li AU - Chenli Li AU - Hanjie Yu AU - Dongsheng Zhou AU - Zhongming Chen ED - Gonzalo Emiliano Aranda Abreu Y1 - 2017-08-23 PY - 2017 T1 - Reducing Neuroinflammation in Psychiatric Disorders: Novel Target of Phosphodiesterase 4 (PDE4) and Developing of the PDE4 Inhibitors N2 - "Mechanisms of Neuroinflammation" book explains how the neuronal cells become swollen at the moment of the blood-brain barrier disruption and how they lose their immunological isolation. A cascade of cytokines and immune cells from the bloodstream enters the nervous system, inflaming neurons and activating the glia. This produces a neuroinflammatory process that can generate different neurodegenerative diseases. Better understanding of mechanisms that are activated at the time when the damage to the brain occurs could lead to the development of suitable therapies that revert the neuronal inflammation and thus prevent further damage to the nervous system. BT - Mechanisms of Neuroinflammation SP - Ch. 1 UR - https://doi.org/10.5772/intechopen.69154 DO - 10.5772/intechopen.69154 SN - 978-953-51-3452-7 PB - IntechOpen CY - Rijeka Y2 - 2024-04-24 ER -