TY  - CHAP
AU  - Naoko Yagishita
AU  - Satoko Aratani
AU  - Hidetoshi Fujita
AU  - Yoshihisa
Yamano
AU  - Kusuki Nishioka
AU  - Toshihiro Nakajima
ED  - Lazaros I. Sakkas
Y1  - 2017-02-22
PY  - 2017
T1  - Synoviolin is a Novel Pathogenic Factor of Arthropathy and Chronic Inflammation
N2  - The pathogenesis of rheumatoid arthritis (RA) is incompletely understood. HLA class II alleles and T cells have been implicated for many years. The discovery of anticitrullinated peptide antibodies (ACPAs), along with the effectiveness of biological treatments targeting cytokines, such as TNF-?, IL-6, and also T cells and B cells, reinforced the pathogenetic role of the respective factors. ACPAs, induced by cigarette smoking and periodontitis in individuals with HLA-DRB1 shared epitope, appear to be autoantigens that initiate the inflammatory immune response in RA. MicroRNAs, part of epigenetic mechanisms, which also include DNA methylation, and histone modification, as well as microbiota, the composition of microbes in body cavities, also appear to influence arthritis and are discussed in this book.
BT  - New Developments in the Pathogenesis of Rheumatoid Arthritis
SP  - Ch. 7
UR  - https://doi.org/10.5772/66352
DO  - 10.5772/66352
SN  - 978-953-51-2970-7
PB  - IntechOpen
CY  - Rijeka
Y2  - 2024-04-26
ER  -