TY - CHAP AU - Ting-Yu Lin AU - Lewis C. Cantley AU - Gina M. DeNicola ED - Jose Antonio Morales-Gonzalez ED - Angel Morales-Gonzalez ED - Eduardo Osiris Madrigal-Santillan Y1 - 2016-12-21 PY - 2016 T1 - NRF2 Rewires Cellular Metabolism to Support the Antioxidant Response N2 - Due to that at present, the majority of diseases are associated with alterations in oxidative stress and inflammatory processes, and in that Nrf-2 is a modulator of these processes; knowing how this transcriptional factor functions and is regulated opens a therapeutic window to diverse diseases. Therefore, the efforts of various investigation groups are centered on finding activators and/or inhibitors of Nrf-2 to prevent or control diverse diseases, for example, cancer, where it would be important to regulate Nrf-2 in order for it to activate apoptosis pathways in cancerogenous cells, or in neurodegenerative diseases where cell death is predominant, it would be important for Nrf-2 to activate antiapoptotic pathways. BT - The Transcription Factor Nrf2 SP - Ch. 2 UR - https://doi.org/10.5772/65141 DO - 10.5772/65141 SN - 978-953-51-2838-0 PB - IntechOpen CY - Rijeka Y2 - 2024-03-29 ER -