TY  - CHAP
AU  - Carola Otth
AU  - Francisca Acuña‐Hinrichsen
AU  - Luis Leyton
AU  - Carolina
Martin
AU  - Margarita I. Concha
ED  - Jozsef Ongradi
Y1  - 2016-09-07
PY  - 2016
T1  - Herpes Simplex Virus Type 1 at the Central Nervous System
N2  - Herpesviruses are unique among viruses as they encode for a complex self-regulatory system, aggressively invade and persist in the host, evade immune defense, alter all regulatory mechanisms of the macroorganism and modify the replication of heterologous viruses. Environmental factors influence these unconventional relationships. Consequently, a single herpesvirus species can be attributed to a wide range of diseases as etiological agents or cofactors. This book is intended to give an overview on selected clinical hot topics: herpes simplex virus encephalitis, persistent infection in the gingiva, thymidine kinase gene expression causing male infertility, and pharmaceutical reactivation of Epstein-Barr virus for oncolysis. Immune evasion mechanisms and new ways to formulate vaccines are exhaustively reviewed. Finally, a surprise: bovine herpesviruses could serve as models to study the pathomechanism of herpesviruses.
BT  - Herpesviridae
SP  - Ch. 2
UR  - https://doi.org/10.5772/64130
DO  - 10.5772/64130
SN  - 978-953-51-2611-9
PB  - IntechOpen
CY  - Rijeka
Y2  - 2024-04-18
ER  -