TY - CHAP AU - Ewan Peter Plant AU - Tatiana Zagorodnyaya AU - Elvira Rodionova AU - Alin Voskanianā€Kordi AU - Vahan Simonyan AU - Zhiping Ye AU - Majid Laassri ED - Manal Mohammad Baddour Y1 - 2016-10-26 PY - 2016 T1 - Application of the New Generation of Sequencing Technologies for Evaluation of Genetic Consistency of Influenza A Vaccine Viruses N2 - The World Health Organization (WHO) estimates that 3-5 million cases of severe influenza worldwide will result in 250,000-500,000 deaths annually. Collectively, data are shared via the WHO's Global Influenza Surveillance and Response System (GISRS), which includes 143 institutions in 113 WHO member states, to help alert the emergence of antigenic variants or the beginning of a pandemic. In April 2009, the Centers for Disease Control and Prevention (CDC) cited the first incidence of human-to-human transmission of pandemic H1N1, also referred to as swine influenza A, which was antigenically distinct from other circulating human H1N1. As the first influenza pandemic of the twenty-first century, pandemic H1N1 was not included in the annual trivalent vaccine regimen, leaving a large majority of the population unprotected from the newly emerging pathogen. BT - Steps Forwards in Diagnosing and Controlling Influenza SP - Ch. 2 UR - https://doi.org/10.5772/64371 DO - 10.5772/64371 SN - 978-953-51-2733-8 PB - IntechOpen CY - Rijeka Y2 - 2024-03-28 ER -