TY - CHAP AU - Tatjana Michel AU - Hans-Peter Wendel AU - Stefanie Krajewski ED - Michael S.D. Kormann Y1 - 2016-05-18 PY - 2016 T1 - Next-Generation Therapeutics: mRNA as a Novel Therapeutic Option for Single-Gene Disorders N2 - Site-specific endonucleases create double-strand breaks within the genome and can be targeted to literally any genetic mutation. Together with a repair template, a correction of the defective locus becomes possible. This book offers insight into the modern tools of genome editing, their hurdles and their huge potential. A new era of in vivo genetic engineering has begun. BT - Modern Tools for Genetic Engineering SP - Ch. 1 UR - https://doi.org/10.5772/62243 DO - 10.5772/62243 SN - 978-953-51-2234-0 PB - IntechOpen CY - Rijeka Y2 - 2024-04-23 ER -