TY - CHAP AU - Sandra Ríos-Arrabal AU - José Antonio Muñoz-Gámez AU - Sergio Manuel Jiménez-Ruíz AU - Jorge Casado-Ruíz AU - Francisco Artacho-Cordón and Josefa León-López ED - Luis Rodrigo Y1 - 2016-09-07 PY - 2016 T1 - Circadian Regulation of Colon Cancer Stem Cells: Implications for Therapy N2 - Colorectal cancer (CRC) is a major health problem because it represents around 10% of all cancers and achieves a worldwide estimate of 1.4 million newly diagnosed cases annually, resulting in approximately 700,000 deaths. Approximately 19-31% of patients present liver metastases. At diagnosis, a further 23-38% will develop extra-hepatic disease. Over the past decade, the widespread use of modern chemotherapeutic and biological agents, combined with laparoscopic surgical techniques, has improved the prognosis of metastatic CRC. A better understanding of the biology of the tumor, along with high efficiency of diagnostic and therapeutic methods, as well as the spread of screening programs, will improve the survival of the CRC patients in the near future. BT - Colorectal Cancer SP - Ch. 2 UR - https://doi.org/10.5772/62323 DO - 10.5772/62323 SN - 978-953-51-2545-7 PB - IntechOpen CY - Rijeka Y2 - 2024-03-28 ER -