TY - CHAP AU - Sergio López-Manzaneda AU - Sara Fañanas-Baquero AU - Virginia Nieto- Romero AU - Francisco-Jose Roman-Rodríguez AU - Maria Fernandez-Garcia AU - Maria J. Pino-Barrio AU - Fatima Rodriguez-Fornes AU - Begoña Diez- Cabezas AU - Maria Garcia-Bravo AU - Susana Navarro AU - Oscar Quintana- Bustamante AU - Jose C. Segovia ED - Michael S.D. Kormann Y1 - 2016-05-18 PY - 2016 T1 - Gene Editing in Adult Hematopoietic Stem Cells N2 - Site-specific endonucleases create double-strand breaks within the genome and can be targeted to literally any genetic mutation. Together with a repair template, a correction of the defective locus becomes possible. This book offers insight into the modern tools of genome editing, their hurdles and their huge potential. A new era of in vivo genetic engineering has begun. BT - Modern Tools for Genetic Engineering SP - Ch. 5 UR - https://doi.org/10.5772/62383 DO - 10.5772/62383 SN - 978-953-51-2234-0 PB - IntechOpen CY - Rijeka Y2 - 2024-04-16 ER -